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Capsaicin and cancer

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https://www.readbyqxmd.com/read/29699594/beneficial-effects-of-curcumin-and-capsaicin-on-cyclophosphamide-induced-premature-ovarian-failure-in-a-rat-model
#1
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Asli Cetin, Nese Basak
BACKGROUND: In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regarding the preservation and restoration of ovarian function before and after oncological treatment because of the reproductive risk of chemotherapeutics and improved long-term survival of cancer patients. In this study, we sought to analyze the effects of curcumin (CRC) and capsaicin (CPS) on cyclophosphamide-induced POF in a rat model...
April 26, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29587290/chemoprevention-and-treatment-of-pancreatic-cancer-update-and-review-of-the-literature
#2
Julia Benzel, Volker Fendrich
BACKGROUND: Pancreatic ductal adenocarcinoma is one of the most lethal types of cancer with a 5-year survival rate of around 7%. Due to the relatively poor prognosis, the potential need of an effective chemoprevention is highly needed. SUMMARY: Different risk factors like smoking or hereditary tumour syndromes should be known for early detection of pancreatic intraepithelial neoplasia. Chemopreventive dietary agents include curcumin, capsaicin and flavonoid, whereas potential chemopreventive drugs compromise aspirin, metformin or statins...
March 27, 2018: Digestion
https://www.readbyqxmd.com/read/29580868/down-regulated-trpv1-expression-contributes-to-melanoma-growth-via-calcineurin-atf3-p53-pathway
#3
Yuqi Yang, Weinan Guo, Jingjing Ma, Peng Xu, Weigang Zhang, Sen Guo, Lin Liu, Jinyuan Ma, Qiong Shi, Zhe Jian, Ling Liu, Gang Wang, Tianwen Gao, Zheyi Han, Chunying Li
Melanoma is the most lethal form of skin cancer with increasing incidence over the years. Due to its rapid proliferative and drastic metastatic capacity, the prognosis of melanoma remains dismal, although the targeted therapy and immunotherapy have gained revolutionary progress recently. Therefore, it is of necessity to further clarify the mechanism of melanoma pathogenesis for developing alternative treatment strategy. TRPV1 is a non-selective Ca2+ channel greatly involved in regulating cell apoptosis, proliferation, metabolism and cancer development, but its role in melanoma remains unknown...
March 23, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29573663/capsaicin-protects-against-testicular-torsion-injury-through-mtor-dependent-mechanism
#4
Nasim Javdan, Seyed Abdulmajid Ayatollahi, Muhammad Iqbal Choudhary, Safaa Al-Hasani, Farzad Kobarfard, Ata Athar, Hamidreza Pazoki-Toroudi
SCOPE: Testicular torsion and subsequent release of reactive oxygen species (ROS) can cause infertility in adults. Oxidative stress following testicular torsion plays an important role in the ýonset and development of apoptotic cell death through dysregulation of the cellular signaling pathways. Anti-inflammatory and antioxidant properties of capsaicin, a bioactive composition present in red peppers, has already been exploited for treatment of the cancer and pain relief. In present work, we evaluated the role of the mammalian target of rapamycin (mTOR) in antioxidant effect of capsaicin against reperfusion injury following testicular torsion...
March 15, 2018: Theriogenology
https://www.readbyqxmd.com/read/29551639/mechanistic-study-of-nonivamide-enhancement-of-hyperthermia-induced-apoptosis-in-u937-cells
#5
Lu Sun, Zheng-Guo Cui, Shahbaz Ahmad Zakki, Qian-Wen Feng, Meng-Ling Li, Hidekuni Inadera
Hyperthermia is one therapeutic tool for damaging and killing cancer cells, with minimal injury to normal tissues. However, its cytotoxic effects alone are insufficient for quantitative cancer cell death. To overcome this limitation, several studies have explored non-toxic enhancers for hyperthermia-induced cell death. Capsaicin may be applicable as a therapeutic tool against various types of cancer. In the present study, we employed nonivamide, a less-pungent capsaicin analogue, to investigate its possible enhancing effects on hyperthermia-induced apoptosis; moreover, we analyzed its molecular mechanism...
March 15, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29498663/capsaicin-and-piperine-can-overcome-multidrug-resistance-in-cancer-cells-to-doxorubicin
#6
Hanmei Li, Sonja Krstin, Shihui Wang, Michael Wink
BACKGROUND: Multidrug resistance (MDR) can develop in cancer cells after treatment with anticancer drugs, mainly due to the overexpression of the ATP-binding cassette (ABC) transporters. We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum , respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters. METHODS: The MTT assay was first used to determine the cytotoxicity of doxorubicin, the alkaloids, and digitonin alone, and then their combinations...
March 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29411905/foxo1-targeting-by-capsaicin-reduces-tissue-damage-after-testicular-torsion
#7
N Javdan, S A Ayatollahi, M Iqbal Choudhary, S Al-Hasani, H Pazoki-Toroudi
Testicular torsion-related oxidative stress causes a sequential chain of DNA damage, lipid peroxidation and cell death that leads to the derangement in the sperm functions and infertility. Capsaicin that has been applied for pain relief and cancer prevention possesses antioxidant properties which can be exploited to confer cell survival under ischaemic testis damage. Wistar male rats weighing 150-200 g were randomly divided into four groups: (i) sham group (all procedures except torsion of testis), (ii) ischaemia group (TT group), (iii) three TT groups treated with different dose of capsaicin (TT + different doses of Cap) and (iv) three control groups treated with different doses of capsaicin (100, 500 and 1000 ug/ml)...
February 7, 2018: Andrologia
https://www.readbyqxmd.com/read/29342359/semiconducting-photothermal-nanoagonist-for-remote-controlled-specific-cancer-therapy
#8
Xu Zhen, Chen Xie, Yuyan Jiang, Xiangzhao Ai, Bengang Xing, Kanyi Pu
Nanomedicines have shown success in cancer therapy, but the pharmacological actions of most nanomedicine are often nonspecific to cancer cells because of utilization of the therapeutic agents that induce cell apoptosis from inner organelles. We herein report the development of semiconducting photothermal nanoagonists that can remotely and specifically initiate the apoptosis of cancer cells from cell membrane. The organic nanoagonists comprise semiconducting polymer nanoparticles (SPNs) and capsaicin (Cap) as the photothermally-responsive nanocarrier and the agonist for activation of transient receptor potential cation channel subfamily V member 1 (TRPV1), respectively...
January 17, 2018: Nano Letters
https://www.readbyqxmd.com/read/29338036/static-magnetic-field-enhances-the-anticancer-efficacy-of-capsaicin-on-hepg2-cells-via-capsaicin-receptor-trpv1
#9
Wei-Ting Chen, Guan-Bo Lin, Shu-Hui Lin, Chueh-Hsuan Lu, Chih-Hsiung Hsieh, Bo-Lun Ma, Chih-Yu Chao
Static magnetic field (SMF) has shown some possibilities for cancer therapies. In particular, the combinational effect between SMF and anti-cancer drugs has drawn scientists' attentions in recent years. However, the underlying mechanism for the drug-specific synergistic effect is far from being understood. Besides, the drugs used are all conventional chemotherapy drugs, which may cause unpleasant side effects. In this study, our results demonstrate for the first time that SMF could enhance the anti-cancer effect of natural compound, capsaicin, on HepG2 cancer cells through the mitochondria-dependent apoptosis pathway...
2018: PloS One
https://www.readbyqxmd.com/read/29258175/capsaicin-friend-or-foe-in-skin-cancer-and-other-related-malignancies
#10
REVIEW
Simona-Roxana Georgescu, Maria-Isabela Sârbu, Clara Matei, Mihaela Adriana Ilie, Constantin Caruntu, Carolina Constantin, Monica Neagu, Mircea Tampa
Capsaicin is the main pungent in chili peppers, one of the most commonly used spices in the world; its analgesic and anti-inflammatory properties have been proven in various cultures for centuries. It is a lipophilic substance belonging to the class of vanilloids and an agonist of the transient receptor potential vanilloid 1 receptor. Taking into consideration the complex neuro-immune impact of capsaicin and the potential link between inflammation and carcinogenesis, the effect of capsaicin on muco-cutaneous cancer has aroused a growing interest...
December 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29246887/anticancer-activity-of-natural-and-synthetic-capsaicin-analogs
#11
Jamie R Friedman, Nicholas A Nolan, Kathleen C Brown, Sarah L Miles, Austin T Akers, Kate W Colclough, Jessica M Seidler, John M Rimoldi, Monica A Valentovic, Piyali Dasgupta
The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although traditionally associated with analgesic activity, recent studies have shown that capsaicin has profound antineoplastic effects in several types of human cancers. However, the applications of capsaicin as a clinically viable drug are limited by its unpleasant side effects, such as gastric irritation, stomach cramps, and burning sensation. This has led to extensive research focused on the identification and rational design of second-generation capsaicin analogs, which possess greater bioactivity than capsaicin...
March 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29188798/capsaicin-enhances-the-antitumor-activity-of-sorafenib-in-hepatocellular-carcinoma-cells-and-mouse-xenograft-tumors-through-increased-erk-signaling
#12
Su-Shan Zhang, Yu-Hao Ni, Chen-Ru Zhao, Zhen Qiao, Hong-Xia Yu, Lu-Yao Wang, Jin-Yan Sun, Chen Du, Jia-Hao Zhang, Li-Ying Dong, KeWei Wang, Jian-Jun Gao
Sorafenib, a small inhibitor of tyrosine protein kinases, is currently the standard chemotherapy drug for the treatment of advanced hepatocellular carcinoma (HCC). Although sorafenib improves the survival of HCC patients, its efficacy is not optimal and requires further improvement. Capsaicin, the major active component of chili peppers from the genus Capsicum, is not only the agonist of TRPV1 channel, but also displays antitumor activity and enhances the sensitivity of cancer cells to cytotoxic drugs. In this study, we investigated the antitumor effects of combined sorafenib and capsaicin on HCC cells in vitro and xenograft tumors...
March 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29185571/capsaicin-inhibits-the-metastasis-of-human-papillary-thyroid-carcinoma-bcpap-cells-through-the-modulation-of-the-trpv1-channel
#13
Shichen Xu, Li Zhang, Xian Cheng, Huixin Yu, Jiandong Bao, Rongrong Lu
Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper. Recently, capsaicin has attracted increasing attention owing to its multiple biological activities. However, the anticancer effects of capsaicin against various types of cancers, especially on thyroid carcinoma, have not been completely elucidated. TRPV1, which can be activated by capsaicin, plays a key role in many biological and physiological processes. In the present study, the anticancer properties of capsaicin against papillary thyroid cancer BCPAP cells were investigated...
January 24, 2018: Food & Function
https://www.readbyqxmd.com/read/29155087/capsaicin-reduces-genotoxicity-colonic-cell-proliferation-and-preneoplastic-lesions-induced-by-1-2-dimethylhydrazine-in-rats
#14
Brunno Felipe Ramos Caetano, Mariana Baptista Tablas, Natália Elias Ferreira Pereira, Nelci Antunes de Moura, Robson Francisco Carvalho, Maria Aparecida Marchesan Rodrigues, Luis Fernando Barbisan
Capsaicin (8-Methyl-N-vanillyl-(trans)-6-nonenamide) is the major pungent ingredient found in chili peppers consumed worldwide. Most reports on capsaicin potential carcinogenicity have yielded inconsistent findings. Some studies have shown that capsaicin exerts anti-proliferative and pro-apoptotic effects on different cancer cell lines, while others have reported an association between capsaicin at high doses with mutagenicity and carcinogenicity. Thus, this study aimed at assessing the effects of capsaicin administration on 1,2-dimethyl-hydrazine (DMH)-induced colon carcinogenesis in male Wistar rats...
January 1, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29100335/breast-cancer-induced-nociceptor-aberrant-growth-and-collateral-sensory-axonal-branching
#15
Matt Austin, Laura Elliott, Niovi Nicolaou, Anna Grabowska, Richard P Hulse
The tumour and neuron interaction has a significant impact upon disease progression and the patients quality of life. In breast cancer patients, it is known that there is an interaction between the tumour microenvironment and the sensory neurons to influence the progression of cancer as well as pain, though these mechanisms still need to be clearly defined. Here it is demonstrated that in a rodent orthotopic model of breast cancer (MDA MB 231) there was an increase in nerve fibre innervation into the tumour microenvironment (protein gene product 9...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29071457/evaluation-of-cebranopadol-a-dually-acting-nociceptin-orphanin-fq-and-opioid-receptor-agonist-in-mouse-models-of-acute-tonic-and-chemotherapy-induced-neuropathic-pain
#16
Kinga Sałat, Anna Furgała, Robert Sałat
BACKGROUND: Cebranopadol (a.k.a. GRT-6005) is a dually acting nociceptin/orphanin FQ and opioid receptor agonist that has been recently developed in Phase 2 clinical trials for painful diabetic neuropathy or cancer pain. It also showed analgesic properties in various rat models of pain and had a better safety profile as compared to equi-analgesic doses of morphine. Since antinociceptive properties of cebranopadol have been studied mainly in rat models, in the present study, we assessed analgesic activity of subcutaneous cebranopadol (10 mg/kg) in various mouse pain models...
October 25, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29048662/capsaicin-inhibits-proliferation-and-induces-apoptosis-in-osteosarcoma-cell-lines-via-the-mitogen%C3%A2-activated-protein-kinase-pathway
#17
Yuan Zhang, Xu Deng, Tao Lei, Chang Yu, Yang Wang, Guosheng Zhao, Xiaoji Luo, Ke Tang, Zhengxue Quan, Dianming Jiang
Capsaicin, a pungent molecular compound present in many hot peppers, exerts anticancer activities against various human cancer cell lines by inducing apoptosis. However, the effects of capsaicin on human osteosarcoma (OS) as well as the related mechanisms remain to be fully elucidated. In the present study, the anticancer effects of capsaicin on 3 human OS cell lines (MG63, 143B and HOS) were investigated. Various concentrations of capsaicin (50-300 µM) effectively decreased cell viability in all 3 OS cell lines in a dose-dependent manner...
November 2017: Oncology Reports
https://www.readbyqxmd.com/read/28899508/pellitorine-an-extract-of-tetradium-daniellii-is-an-antagonist-of-the-ion-channel-trpv1
#18
Zoltán Oláh, Dóra Rédei, László Pecze, Csaba Vizler, Katalin Jósvay, Péter Forgó, Zoltán Winter, György Dombi, Gerda Szakonyi, Judit Hohmann
BACKGROUND: Transient Receptor Potential Vanilloid 1 (TRPV1) confers noxious heat and inflammatory pain signals in the peripheral nervous system. Clinical trial of resiniferatoxin from Euphorbia species is successfully aimed at TRPV1 in cancer pain management and heading toward new selective painkiller status that further validates this target for drug discovery efforts. Evodia species, used in traditional medicine for hundreds of years, are a recognised source of different TRPV1 agonists, but no antagonist has yet been reported...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28841784/regulation-of-microrna-using-promising-dietary-phytochemicals-possible-preventive-and-treatment-option-of-malignant-mesothelioma
#19
REVIEW
Md Abu Sayeed, Massimo Bracci, Guendalina Lucarini, Raffaella Lazzarini, Roberto Di Primio, Lory Santarelli
Malignant mesothelioma (MM) is a very aggressive, lethal cancer, and its incidence is increasing worldwide. Development of multi-drug resistance, therapy related side-effects, and disease recurrence after therapy are the major problems for the successful treatment of MM. Emerging evidence indicates that dietary phytochemicals can exert anti-cancer activities by regulating microRNA expression. Until now, only one dietary phytochemical (ursolic acid) has been reported to have MM microRNA regulatory ability. A large number of dietary phytochemicals still remain to be tested...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28768483/live-cell-calcium-imaging-of-adherent-and-non-adherent-gl261-cells-reveals-phenotype-dependent-differences-in-drug-responses
#20
Averey D Strong, Richard L Daniels
BACKGROUND: The tumor-derived GL261 cell line is used as a model for studying glioblastoma and other high-grade gliomas, and can be cultured adherently or as free-floating aggregates known as neurospheres. These different culture conditions give rise to distinct phenotypes, with increased tumorigenicity displayed by neurosphere-cultured cells. An important technique for understanding GL261 pathobiology is live cell fluorescent imaging of intracellular calcium. However, live cell imaging of GL261 neurospheres presents a technical challenge, as experimental manipulations where drugs are added to the extracellular media cause the cells to move during analysis...
August 2, 2017: BMC Cancer
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