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Cruciferous vegetables and cancer

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https://www.readbyqxmd.com/read/27880994/isothiocyanates-in-brassica-potential-anti-cancer-agents
#1
Sharma Anubhuti, Sharma Ashok, Yadav Prashant, Singh Dhiraj
Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic, display anti-carcinogenic activity because they reduce activation of carcinogens and increase their detoxification. This minireview summarizes the current knowledge on isothiocyanates and focuses on their role as potential anti-cancer agents.
January 9, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27878984/sulforaphane-induced-apoptosis-in-xuanwei-lung-adenocarcinoma-cell-line-xwlc-05
#2
Lan Zhou, Qian Yao, Yan Li, Yun-Chao Huang, Hua Jiang, Chuan-Qiong Wang, Lei Fan
BACKGROUND: Xuanwei district in Yunnan Province has the highest incidence of lung cancer in China, especially among non-smoking women. Cruciferous vegetables can reduce lung cancer risk by prompting a protective mechanism against respiratory tract inflammation caused by air pollution, and are rich in sulforaphane, which can induce changes in gene expression. We investigated the effect of sulforaphane-induced apoptosis in Xuanwei lung adenocarcinoma cell line (XWCL-05) to explore the value of sulforaphane in lung cancer prevention and treatment...
November 23, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27867044/mitochondrial-dysfunction-in-cancer-chemoprevention-by-phytochemicals-from-dietary-and-medicinal-plants
#3
REVIEW
Anuradha Sehrawat, Ruchi Roy, Subrata K Pore, Eun-Ryeong Hahm, Suman K Samanta, Krishna B Singh, Su-Hyeong Kim, Kamayani Singh, Shivendra V Singh
Cancer chemoprevention, a scientific term coined by Dr. Sporn in the late seventies, implies use of natural or synthetic chemicals to block, delay or reverse carcinogenesis. Phytochemicals derived from edible and medicinal plants have been studied rather extensively for cancer chemoprevention using preclinical models in the past few decades. Nevertheless, some of these agents (e.g., isothiocyanates from cruciferous vegetables like broccoli and watercress) have already entered into clinical investigations. Examples of widely studied and highly promising phytochemicals from edible and medicinal plants include cruciferous vegetables constituents (phenethyl isothiocyanate, benzyl isothiocyanate, and sulforaphane), withaferin A (WA) derived from a medicinal plant (Withania somnifera) used heavily in Asia, and an oriental medicine plant component honokiol (HNK)...
November 17, 2016: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/27818231/epigenetic-reactivation-of-rassf1a-by-phenethyl-isothiocyanate-peitc-and-promotion-of-apoptosis-in-lncap-cells
#4
Sarandeep S S Boyanapalli, Wenji Li, Francisco Fuentes, Yue Guo, Christina N Ramirez, Ximena-Parades Gonzalez, Douglas Pung, Ah-Ng Tony Kong
Epigenetic silencing of tumor suppressor genes is a phenomenon frequently observed in multiple cancers. Ras-association domain family 1 isoform A (RASSF1A) is a well-characterized tumor suppressor that belongs to the Ras-association domain family. Several studies have demonstrated that hypermethylation of the RASSF1A promoter is frequently observed in lung, prostate, and breast cancers. Phenethyl isothiocyanate (PEITC), a phytochemical abundant in cruciferous vegetables, possesses chemopreventive activities; however, its potential involvement in epigenetic mechanisms remains elusive...
November 3, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27765931/the-natural-compound-sulforaphene-as-a-novel-anticancer-reagent-targeting-pi3k-akt-signaling-pathway-in-lung-cancer
#5
Ming Yang, Haiyong Wang, Mo Zhou, Weilin Liu, Pengqun Kuang, Hao Liang, Qipeng Yuan
Lung cancer is one of the leading causes of cancer death worldwide. Isothiocyanates from cruciferous vegetables been shown to possess anticarcinogenic activities in lung malignances. We previously found sulforaphene (4-methylsufinyl-3-butenyl isothiocyanate, SFE), one new kind of isothiocyanates, existing in a relative high abundance in radish seeds. An efficient methodology based on macroporous resin and preparative high-performance liquid chromatography was developed to isolate SFE in reasonably large quantities, high purity and low cost...
September 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27716619/alpha-fetoprotein-antagonises-benzyl-isothiocyanate-inhibition-of-the-malignant-behaviors-of-hepatocellular-carcinoma-cells
#6
Mingyue Zhu, Wei Li, Junli Guo, Yan Lu, Xu Dong, Bo Lin, Yi Chen, Xueer Zhang, Mengsen Li
Benzyl isothiocyanate (BITC) is a dietary isothiocyanate derived from cruciferous vegetables. Recent studies showed that BITC inhibited the growth of many cancer cells, including hepatocellular carcinoma (HCC) cells. Alpha-fetoprotein (AFP) is a important molecule for promoting progression of HCC, in the present investigation, we explore the influence of AFP on the role of BITC in the malignant behaviours of HCC cells, and the potential underlying mechanisms. We found thatBITC inhibited viability, migration, invasion and induced apoptosis of human liver cancer cell lines, Bel 7402(AFP producer) and HLE(non-AFP producer) cells in vitro...
October 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27693243/benzyl-isothiocyanate-promotes-apoptosis-of-oral-cancer-cells-via-an-acute-redox-stress-mediated-dna-damage-response
#7
Yao-Tsung Yeh, Yen-Nien Hsu, Sheng-Yun Huang, Jian-Sheng Lin, Zi-Feng Chen, Nan-Haw Chow, Shu-Hui Su, Huey-Wen Shyu, Ching-Chiang Lin, Wu-Tein Huang, Hua Yeh, Yu-Chia Chih, Yu-Hsuan Huang, Shu-Jem Su
Benzyl isothiocyanate (BITC) is a cruciferous vegetable-derived compound with anticancer properties in human cancer cells. However, its anticancer potential and underlying mechanisms remain absent in human oral cancer cells. Results indicate that BITC inhibits growth, promotes G2/M phase arrest and triggers apoptosis of OC2 cells with a minimal toxicity to normal cells. BITC-induced cell death was completely prevented by pretreatment with thiol-containing redox compounds including N-acetyl-l-cysteine (NAC), glutathione (GSH), dithiothreitol, and 2-mercaptoethanol, but not free radical scavengers mito-TEMPO, catalase, apocynin, l-NAME and mannitol...
September 28, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27684484/irreversible-inhibition-of-glutathione-s-transferase-by-phenethyl-isothiocyanate-peitc-a-dietary-cancer-chemopreventive-phytochemical
#8
Vandana Kumari, Marzena A Dyba, Ryan J Holland, Yu-He Liang, Shivendra V Singh, Xinhua Ji
Dietary isothiocyanates abundant as glucosinolate precursors in many edible cruciferous vegetables are effective for prevention of cancer in chemically-induced and transgenic rodent models. Some of these agents, including phenethyl isothiocyanate (PEITC), have already advanced to clinical investigations. The primary route of isothiocyanate metabolism is its conjugation with glutathione (GSH), a reaction catalyzed by glutathione S-transferase (GST). The pi class GST of subunit type 1 (hGSTP1) is much more effective than the alpha class GST of subunit type 1 (hGSTA1) in catalyzing the conjugation...
2016: PloS One
https://www.readbyqxmd.com/read/27671815/indole-3-carbinol-and-its-role-in-chronic-diseases
#9
Barbara Licznerska, Wanda Baer-Dubowska
Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindolylmethane (DIM) exert several biological activities on cellular and molecular levels, which contribute to their well-recognized chemoprevention potential. Initially, these compounds were classified as blocking agents that increase drug-metabolizing enzyme activity. Now it is widely accepted that I3C and DIM affect multiple signaling pathways and target molecules controlling cell division, apoptosis, or angiogenesis deregulated in cancer cells...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27627923/sulforaphane-induces-cell-death-through-g2-m-phase-arrest-and-triggers-apoptosis-in-hct-116-human-colon-cancer-cells
#10
Kuo-Ching Liu, Ting-Ying Shih, Chao-Lin Kuo, Yi-Shih Ma, Jiun-Long Yang, Ping-Ping Wu, Yi-Ping Huang, Kuang-Chi Lai, Jing-Gung Chung
Sulforaphane (SFN), an isothiocyanate, exists exclusively in cruciferous vegetables, and has been shown to possess potent antitumor and chemopreventive activity. However, there is no available information that shows SFN affecting human colon cancer HCT 116 cells. In the present study, we found that SFN induced cell morphological changes, which were photographed by contrast-phase microscopy, and decreased viability. SFN also induced G2/M phase arrest and cell apoptosis in HCT 116 cells, which were measured with flow cytometric assays...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27538743/harnessing-the-power-of-cruciferous-vegetables-developing-a-biomarker-for-brassica-vegetable-consumption-using-urinary-3-3-diindolylmethane
#11
Naomi Fujioka, Benjamin W Ransom, Steven G Carmella, Pramod Upadhyaya, Bruce R Lindgren, Astia Roper-Batker, Dorothy K Hatsukami, Vincent A Fritz, Charles Rohwer, Stephen S Hecht
Glucobrassicin in Brassica vegetables gives rise to indole-3-carbinol (I3C), a compound with potent anticancer effects in preclinical models. We previously showed that the urinary metabolite 3,3'-diindolylmethane (DIM) could discriminate between volunteers fed high and low doses of Brassica vegetables. However, the quantitative relationship between glucobrassicin exposure and urinary DIM level is unclear. We conducted a clinical trial to examine the hypotheses that a range of glucobrassicin exposure from Brassica vegetables is reflected in urinary DIM and that this effect plateaus...
October 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27518576/prostate-cancer-progression-and-mortality-a-review-of-diet-and-lifestyle-factors
#12
Sam F Peisch, Erin L Van Blarigan, June M Chan, Meir J Stampfer, Stacey A Kenfield
PURPOSE: To review and summarize evidence on the role of diet and lifestyle factors and prostate cancer progression, with a specific focus on habits after diagnosis and the risk of subsequent disease recurrence, progression, or death. METHODS: Given the well-documented heterogeneity of prostate cancer and the long survivorship of the majority of diagnoses, our goal was to summarize and describe modifiable risk factors for clinically relevant prostate cancer. We focused where possible on epidemiologic studies of post-diagnostic habits and prostate cancer progression, defined as recurrence (e...
August 12, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27499349/sulforaphane-increases-the-efficacy-of-anti-androgens-by-rapidly-decreasing-androgen-receptor-levels-in-prostate-cancer-cells
#13
Namrata Khurana, Sudha Talwar, Partha K Chandra, Pankaj Sharma, Asim B Abdel-Mageed, Debasis Mondal, Suresh C Sikka
Prostate cancer (PCa) cells utilize androgen for their growth. Hence, androgen deprivation therapy (ADT) using anti-androgens, e.g. bicalutamide (BIC) and enzalutamide (ENZ), is a mainstay of treatment. However, the outgrowth of castration resistant PCa (CRPC) cells remains a significant problem. These CRPC cells express androgen receptor (AR) and utilize the intratumoral androgen towards their continued growth and invasion. Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, can decrease AR protein levels...
October 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27485253/evaluation-of-synergistic-effects-of-sulforaphene-with-photodynamic-therapy-in-human-cervical-cancer-cell-line
#14
R Biswas, A Mondal, S Chatterjee, J C Ahn
Sulforaphene from cruciferous vegetable has shown to modulate various signaling pathways of apoptosis. But it has not yet been studied extensively for the cervical cancer treatment. Previous studies show the promising role of photodynamic therapy for cervical cancer. Here, we confirm that sulforaphene can synergistically enhance the efficacy of photodynamic therapy. Human cervical cancer cells HeLa were treated with a very low dose of sulforaphene (2.0 μg/ml) and photodynamic therapy with radachlorin (0.5 μg/ml) at a fluence of 27 J/cm(2) (30 milliwatts/cm(2), λmax ∼ 670 ± 3 nm)...
November 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27447608/cellular-and-molecular-mechanisms-of-3-3-diindolylmethane-in-gastrointestinal-cancer
#15
REVIEW
Soo Mi Kim
Studies in humans have shown that 3,3'-diindolylmethane (DIM), which is found in cruciferous vegetables, such as cabbage and broccoli, is effective in the attenuation of gastrointestinal cancers. This review presents the latest findings on the use, targets, and modes of action of DIM for the treatment of human gastrointestinal cancers. DIM acts upon several cellular and molecular processes in gastrointestinal cancer cells, including apoptosis, autophagy, invasion, cell cycle regulation, metastasis, angiogenesis, and endoplasmic reticulum (ER) stress...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27423466/sulforaphane-attenuates-activation-of-nlrp3-and-nlrc4-inflammasomes-but-not-aim2-inflammasome
#16
Jiseon Lee, Huijeong Ahn, Eui-Ju Hong, Beum-Soo An, Eui-Bae Jeung, Geun-Shik Lee
Sulforaphane (SFN), a compound within the isothiocyanate group of organosulfur compounds originating from cruciferous vegetables, has gained attention for its antioxidant, anti-inflammatory, and cancer chemopreventive properties. However, the effects of SFN on inflammasomes, which are multi-protein complexes that induce maturation of interleukin (IL)-1β, have been poorly studied. In this study, we investigated the effects of SFN on the assembly of NLRP3, NLRC4, and AIM2 inflammasomes as well as on the priming step of NLRP3 inflammasome in murine macrophages...
August 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27413713/a-potential-role-for-estrogen-in-cigarette-smoke-induced-microrna-alterations-and-lung-cancer
#17
REVIEW
Amit Cohen, Mario Alberto Burgos-Aceves, Yoav Smith
Alteration in the expression of microRNAs (miRNAs) is associated with oncogenesis and cancer progression. In this review we aim to suggest that elevated levels of estrogens and their metabolites inside the lungs as a result of cigarette smoke exposure can cause widespread repression of miRNA and contribute to lung tumor development. Anti-estrogenic compounds, such as the components of cruciferous vegetables, can attenuate this effect and potentially reduce the risk of lung cancer (LC) among smokers.
June 2016: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/27409631/food-habits-lifestyle-factors-and-risk-of-prostate-cancer-in-central-argentina-a-case-control-study-involving-self-motivated-health-behavior-modifications-after-diagnosis
#18
Sandaly O S Pacheco, Fabio J Pacheco, Gimena M J Zapata, Julieta M E Garcia, Carlos A Previale, Héctor E Cura, Winston J Craig
Cancer is the second most important non-communicable disease worldwide and disproportionately impacts low- to middle-income countries. Diet in combination with other lifestyle habits seems to modify the risk for some cancers but little is known about South Americans. Food habits of Argentinean men pre- and post-diagnosis of prostate cancer (n = 326) were assessed along with other lifestyle factors. We studied whether any of the behaviors and risk factors for prostate cancer were found in men with other cancers (n = 394), compared with control subjects (n = 629)...
2016: Nutrients
https://www.readbyqxmd.com/read/27389525/biosynthesis-of-the-high-value-plant-secondary-product-benzyl-isothiocyanate-via-functional-expression-of-multiple-heterologous-enzymes-in-e-coli
#19
Feixia Liu, Han Yang, Limin Wang, Bo Yu
Plants produce a wide variety of secondary metabolites of high nutraceutical and pharmaceutical importance. Isothiocyanates, which are found abundantly in cruciferous vegetables, are believed to reduce the risk of several types of cancers and cardiovascular diseases. The challenges arising from the structural diversity and complex chemistry of these compounds have raised a strong interest in producing them in high amounts in microbes. To date, there is no report on the production of such compounds by prokaryotes...
July 7, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27374852/inhibition-of-mitochondrial-fusion-is-an-early-and-critical-event-in-breast-cancer-cell-apoptosis-by-dietary-chemopreventative-benzyl-isothiocyanate
#20
Anuradha Sehrawat, Claudette St Croix, Catherine J Baty, Simon Watkins, Dhanir Tailor, Rana P Singh, Shivendra V Singh
Benzyl isothiocyanate (BITC) is a highly promising phytochemical abundant in cruciferous vegetables with preclinical evidence of in vivo efficacy against breast cancer in xenograft and transgenic mouse models. Mammary cancer chemoprevention by BITC is associated with apoptotic cell death but the underlying mechanism is not fully understood. Herein, we demonstrate for the first time that altered mitochondrial dynamics is an early and critical event in BITC-induced apoptosis in breast cancer cells. Exposure of MCF-7 and MDA-MB-231 cells to plasma achievable doses of BITC resulted in rapid collapse of mitochondrial filamentous network...
September 2016: Mitochondrion
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