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Cruciferous vegetables and cancer

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https://www.readbyqxmd.com/read/29644960/glucosinolate-and-isothiocyanate-intakes-are-inversely-associated-with-breast-cancer-risk-a-case-control-study-in-china
#1
Nai-Qi Zhang, Suzanne C Ho, Xiong-Fei Mo, Fang-Yu Lin, Wu-Qing Huang, Hong Luo, Jing Huang, Cai-Xia Zhang
Although previous studies have investigated the association of cruciferous vegetable consumption with breast cancer risk, few studies focused on the association between bioactive components in cruciferous vegetables, glucosinolates (GSL) and isothiocyanates (ITC), and breast cancer risk. This study aimed to examine the association between consumption of cruciferous vegetables and breast cancer risk according to GSL and ITC contents in a Chinese population. A total of 1485 cases and 1506 controls were recruited into this case-control study from June 2007 to March 2017...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29607466/autophagy-inhibition-improves-the-chemotherapeutic-efficacy-of-cruciferous-vegetable-derived-diindolymethane-in-a-murine-prostate-cancer-xenograft-model
#2
Hossam Draz, Alexander A Goldberg, Emma S Tomlinson Guns, Ladan Fazli, Stephen Safe, J Thomas Sanderson
Prostate cancer is the second leading cause of cancer-related deaths in men in North America and there is an urgent need for development of more effective therapeutic treatments against this disease. We have recently shown that diindolylmethane (DIM) and several of its halogenated derivatives (ring-DIMs) induce death and protective autophagy in human prostate cancer cells. However, the in vivo efficacy of ring-DIMs and the use of autophagy inhibitors as adjuvant therapy have not yet been studied in vivo. The objective of this study was to determine these effects on tumor growth in nude CD-1 mice bearing bioluminescent androgen-independent PC-3 human prostate cancer cells...
April 2, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29599332/phenethyl-isothiocyanate-induces-apoptotic-cell-death-through-the-mitochondria-dependent-pathway-in-gefitinib-resistant-nci-h460-human-lung-cancer-cells-in-vitro
#3
Te-Chun Hsia, Yi-Ping Huang, Yi-Wen Jiang, Hsin-Yu Chen, Zheng-Yu Cheng, Yung-Ting Hsiao, Cheng-Yen Chen, Shu-Fen Peng, Fu-Shin Chueh, Yu-Cheng Chou, Jing-Gung Chung
BACKGROUND/AIM: Some lung cancer patients treated with gefitinib develop resistance to this drug resulting in unsatisfactory treatment outcomes. Phenethyl isothiocyanate (PEITC), present in our common cruciferous vegetables, exhibits anticancer activities in many human cancer cell lines. Currently, there is no available information on the possible modification of gefitinib resistance of lung cancer in vitro by PEITC. Thus, the effects of PEITC on gefitinib resistant lung cancer NCI-H460 cells were investigated in vitro...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29595853/phenethyl-isothiocyanate-in-combination-with-dibenzoylmethane-inhibits-the-androgen-independent-growth-of-prostate-cancer-cells
#4
Huarong Huang, Yan He, Lanyue Zhang, Hongping Xiang, Dongli Li, Wenfeng Liu, Xue-Tao Xu, Susan Goodin, Kun Zhang, Xi Zheng
Phenethyl isothiocyanate (PEITC) is a naturally occurring compound found in some cruciferous vegetables. Dibenzoylmethane (DBM) is a minor constituent of licorice. Both compounds have been shown to exert anticancer activities. In the present study, we determined the effects of PEITC and DBM alone or in combination on androgen-independent growth of human prostate cancer cells cultured in vitro and prostate VCaP xenograft tumors in severe combined immunodeficient (SCID) mice. PEITC and DBM in combination had stronger effects on inhibiting the growth and inducing apoptosis than either compound alone in cultured prostate cancer cells...
March 29, 2018: Food & Function
https://www.readbyqxmd.com/read/29574860/a-dietary-pattern-based-on-estrogen-metabolism-is-associated-with-breast-cancer-risk-in-a-prospective-cohort-of-postmenopausal-women
#5
Mark A Guinter, Alexander C McLain, Anwar T Merchant, Dale P Sandler, Susan E Steck
Increased exposure to estrogen is a risk factor for postmenopausal breast cancer, and dietary factors can influence estrogen metabolism. However, studies of diet and breast cancer have been inconclusive. We developed a dietary pattern associated with levels of unconjugated estradiol and the ratio of 2- and 16-hydroxylated estrogen metabolites in a subsample of Prostate, Lung, Colorectal and Ovarian Screening Trial (PLCO) participants (n=653) using reduced rank regression, and examined its association with postmenopausal breast cancer prospectively in the larger PLCO cohort (n=27,488)...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29573203/cruciferous-vegetables-and-risk-of-cancers-of-the-gastrointestinal-tract
#6
REVIEW
Ian Terence Johnson
Cancers of the oropharyngeal tissues, oesophagus, stomach and colorectum are amongst the most common causes of death from cancer throughout the world. Higher consumption of fruits and vegetables is thought to be protective, and cruciferous vegetables are of particular interest because of their unique role as a source of biologically active glucosinolate breakdown products. A literature review of primary studies and meta-analyses indicates that higher consumption of cruciferous vegetables probably reduces the risk of colorectal and gastric cancers by approximately 8% and 19% respectively...
March 23, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29545400/inhibition-of-glycolysis-in-prostate-cancer-chemoprevention-by-phenethyl-isothiocyanate
#7
Krishna B Singh, Eun-Ryeong Hahm, Lora H Rigatti, Daniel P Normolle, Jian-Min Yuan, Shivendra V Singh
We have shown previously that dietary administration of phenethyl isothiocyanate (PEITC), a small molecule from edible cruciferous vegetables, significantly decreases the incidence of poorly-differentiated prostate cancer in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice without any side effects. In this study, we investigated the role of c-Myc-regulated glycolysis in prostate cancer chemoprevention by PEITC. Exposure of LNCaP (androgen-responsive) and 22Rv1 (castration-resistant) human prostate cancer cells to PEITC resulted in suppression of expression as well as transcriptional activity of c-Myc...
March 15, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29532757/targeting-the-microcirculation-by-indole-3-carbinol-effects-on-angiogenesis-thrombosis-and-inflammation
#8
Emmanuel Ampofo, Beate M Schmitt, Michael M Menger, Matthias W Laschke
The pharmacological targeting of microcirculatory dysregulations is a therapeutic strategy for the treatment of numerous pathological conditions, such as cancer, thrombosis and inflammation. A promising candidate for this purpose is indole-3-carbinol (I3C), a phytochemical compound of cruciferous vegetables. As summarized in this review, I3C affects multiple molecular and cellular processes within the microcirculation due to its pleiotropic action profile. These include angiogenesis, leukocyte-endothelial cell interaction, cytokine and reactive oxygen species (ROS) production, thrombus formation and microvascular leakage...
March 12, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29532604/the-role-of-non-coding-rnas-and-isothiocyanates-in-cancer
#9
REVIEW
Samantha L Martin, Kendra J Royston, Trygve O Tollefsbol
Cancer is the second leading cause of mortalities in the United States, only exceeded by heart disease. Current cancer treatments include chemotherapy, surgery and/or radiation. Due to the often harsh effects of current cancer therapies, investigators are focusing their efforts on cancer prevention mediated by dietary phytochemicals. Since the discovery that cancer can be initiated by and progress through both genetic and epigenetic pathways, there has been a significant surge in studies on epigenetic effects mediated by nutritive compounds...
March 12, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29525530/sulforaphane-epigenetically-demethylates-the-cpg-sites-of-the-mir-9-3-promoter-and-reactivates-mir-9-3-expression-in-human-lung-cancer-a549-cells
#10
Linbo Gao, David Cheng, Jie Yang, Renyi Wu, Wenji Li, Ah-Ng Kong
Increasing evidence suggests that epigenetic aberrations contribute to the development and progression of cancers such as lung cancer. The promoter region of miR-9-3 was recently found to be hypermethylated in lung cancer, resulting in down-regulation of miR-9-3 and poor patient prognosis. Sulforaphane (SFN), a natural compound that is obtained from cruciferous vegetables, has potent anticancer activities. In this study, we aimed to investigate the effect of SFN on restoring the miR-9-3 level in lung cancer A549 cells through epigenetic regulation...
February 9, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29518137/sulforaphane-potentiates-anticancer-effects-of-doxorubicin-and-attenuates-its-cardiotoxicity-in-a-breast-cancer-model
#11
Chhanda Bose, Sanjay Awasthi, Rajendra Sharma, Helen BeneŇ°, Martin Hauer-Jensen, Marjan Boerma, Sharda P Singh
Breast cancer is the most common malignancy in women of the Western world. Doxorubicin (DOX) continues to be used extensively to treat early-stage or node-positive breast cancer, human epidermal growth factor receptor-2 (HER2)-positive breast cancer, and metastatic disease. We have previously demonstrated in a mouse model that sulforaphane (SFN), an isothiocyanate isolated from cruciferous vegetables, protects the heart from DOX-induced toxicity and damage. However, the effects of SFN on the chemotherapeutic efficacy of DOX in breast cancer are not known...
2018: PloS One
https://www.readbyqxmd.com/read/29468815/isothiocyanates-translating-the-power-of-plants-to-people
#12
REVIEW
Dushani L Palliyaguru, Jian-Min Yuan, Thomas W Kensler, Jed W Fahey
Isothiocyanates from cruciferous vegetables have been studied extensively in cells and in animals for their disease preventive and therapeutic effects. However, translating their utility to human populations has been both limited and challenging. Herein, clinical trials employing two isothiocyanates, sulforaphane (SFN; 1-Isothiocyanato-4-(methylsulfinyl) butane) and phenethyl isothiocyanate (PEITC; 2-isothiocyanatoethylbenzene) that are isolated principally from broccoli and watercress, respectively, are summarized and discussed...
February 21, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29466374/storage-in-high-barrier-pouches-increases-the-sulforaphane-concentration-in-broccoli-florets
#13
Yoshio Makino, Yuto Nishimura, Seiichi Oshita, Takaharu Mizosoe, Takashi Akihiro
Sulforaphane is a phytochemical that is usually found in cruciferous vegetables and is known to have a depressive effect on gastric cancer. Preliminary investigations showed that the sulforaphane concentration in broccoli (Brassica oleracea var. italica) florets increased under anoxia. Therefore, in the present study, we examined the effect of different atmospheric conditions on the sulforaphane concentration in broccoli and also tested whether there are concurrent effects on the concentration of ethanol, which is an unfavorable byproduct of fermentation...
2018: PloS One
https://www.readbyqxmd.com/read/29457582/green-leafy-and-cruciferous-vegetable-consumption-and-risk-of-type-2-diabetes-results-from-the-singapore-chinese-health-study-and-meta-analysis
#14
Guo-Chong Chen, Woon-Puay Koh, Jian-Min Yuan, Li-Qiang Qin, Rob M van Dam
Several previous prospective studies suggest that consumption of green leafy and cruciferous vegetables may lower the risk of type 2 diabetes (T2D). We investigated the association between consumption of different types of vegetables in relation to T2D risk in an Asian Population. We included 45 411 participants (age range: 45-74 years) of the Singapore Chinese Health Study (SCHS) free of diabetes, cancer or CVD at baseline (1993-1998). Dietary information was collected using a validated FFQ. Physician-diagnosed incident diabetes was reported at follow-up I (1999-2004) and II (2006-2010) interviews...
February 19, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29451459/apiaceous-vegetables-and-cruciferous-phytochemicals-reduced-phip-dna-adducts-in-prostate-but-not-in-pancreas-of-wistar-rats
#15
Jae Kyeom Kim, Marissa A McCormick, Cynthia M Gallaher, Daniel D Gallaher, Sabrina P Trudo
We previously showed rats fed with apiaceous vegetables, but not with their putative chemopreventive phytochemicals, reduced colonic DNA adducts formed by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary procarcinogen. We report here the effects of feeding apiaceous and cruciferous vegetables versus their purified predominant phytochemicals, either alone or combined, on prostate and pancreatic PhIP-DNA adduct formation. In experiment I, male Wistar rats received three supplemented diets: CRU (cruciferous vegetables), API (apiaceous vegetables), and CRU+API (both types of vegetables)...
February 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29401293/fruit-and-vegetable-consumption-and-risk-of-endometriosis
#16
H R Harris, A C Eke, J E Chavarro, S A Missmer
STUDY QUESTION: Is there an association between intake of fruits and vegetables and risk of laparoscopically confirmed endometriosis? SUMMARY ANSWER: Higher intake of fruits, particularly citrus fruits, is associated with a lower risk of endometriosis. WHAT IS KNOWN ALREADY: Two case-control studies have examined the associations between fruit and vegetable intake and endometriosis risk with contrasting results. Diets rich in fruits and vegetables include higher levels of pro-vitamin A nutrients (alpha-carotene, beta-carotene, beta-cryptoxanthin) and women with endometriosis have been reported to have lower intake of vitamin A than women without endometriosis...
April 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29376497/l-sulforaphane-confers-protection-against-oxidative-stress-in-an-in-vitro-model-of-age-related-macular-degeneration
#17
Nabeela Khadija Dulull, Daniel Anthony Dias, Thilini Rasika Thrimawithana, Faith Ai Ai Kwa
BACKGROUND: In age-related macular degeneration, oxidative damage and abnormal neovascularization in the retina are caused by the upregulation of vascular endothelium growth factor and reduced expression of Glutathione-S-transferase genes. Current treatments are only palliative. Compounds from cruciferous vegetables (e.g. L-Sulforaphane) have been found to restore normal gene expression levels in diseases including cancer via the activity of histone deacetylases and DNA methyltransferases, thus retarding disease progression...
January 25, 2018: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29364159/elucidating-the-role-of-cd84-and-ahr-in-modulation-of-lps-induced-cytokines-production-by-cruciferous-vegetable-derived-compounds-indole-3-carbinol-and-3-3-diindolylmethane
#18
Thomas T Y Wang, Quynhchi Pham, Young S Kim
Modulation of the immune system by cancer protective food bioactives has preventive and therapeutic importance in prostate cancer, but the mechanisms remain largely unclear. The current study tests the hypothesis that the diet-derived cancer protective compounds, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), affect the tumor microenvironment by regulation of inflammatory responses in monocytes and macrophages. We also ask whether I3C and DIM act through the aryl hydrocarbon (AHR)-dependent pathway or the signaling lymphocyte activation molecule (SLAM) family protein CD84-mediated pathway...
January 24, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29348534/anti-cancer-activities-of-allyl-isothiocyanate-and-its-conjugated-silicon-quantum-dots
#19
Peng Liu, Mehrnaz Behray, Qi Wang, Wei Wang, Zhigang Zhou, Yimin Chao, Yongping Bao
Allyl isothiocyanate (AITC), a dietary phytochemical in some cruciferous vegetables, exhibits promising anticancer activities in many cancer models. However, previous data showed AITC to have a biphasic effect on cell viability, DNA damage and migration in human hepatoma HepG2 cells. Moreover, in a 3D co-culture of HUVEC with pericytes, it inhibited tube formation at high doses but promoted this at low doses, which confirmed its biphasic effect on angiogenesis. siRNA knockdown of Nrf2 and glutathione inhibition abolished the stimulation effect of AITC on cell migration and DNA damage...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331658/sulforaphene-enhances-the-efficacy-of-photodynamic-therapy-in-anaplastic-thyroid-cancer-through-ras-raf-mek-erk-pathway-suppression
#20
Saswata Chatterjee, Yunhee Rhee, Phil-Sang Chung, Rui-Feng Ge, Jin-Chul Ahn
Sulforaphene (SFE), a natural isothiocyanate from cruciferous vegetables has shown a potential anticancer effect against cervical and lung cancer. Palliative treatments like photodynamic therapy (PDT) are being implemented for a long time however, the results are still not promising in case of aggressive cancers like anaplastic thyroid cancer. The objective of this work is to establish an alternative method with the combination of photofrin-PDT and sulforaphene, a natural isothiocyanate from cruciferous vegetables, against human anaplastic thyroid cancer to enhance the efficacy of PDT...
February 2018: Journal of Photochemistry and Photobiology. B, Biology
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