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Fish oil and cancer

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https://www.readbyqxmd.com/read/29139048/high-adherence-to-the-western-prudent-and-mediterranean-dietary-patterns-and-risk-of-gastric-adenocarcinoma-mcc-spain-study
#1
Adela Castelló, Nerea Fernández de Larrea, Vicente Martín, Verónica Dávila-Batista, Elena Boldo, Marcela Guevara, Víctor Moreno, Gemma Castaño-Vinyals, Inés Gómez-Acebo, Guillermo Fernández-Tardón, Rosana Peiró, Rocío Olmedo-Requena, Rocio Capelo, Carmen Navarro, Silvino Pacho-Valbuena, Beatriz Pérez-Gómez, Manolis Kogevinas, Marina Pollán, Nuria Aragonés
BACKGROUND: The influence of dietary habits on the development of gastric adenocarcinoma is not clear. The objective of the present study was to explore the association of three previously identified dietary patterns with gastric adenocarcinoma by sex, age, cancer site, and morphology. METHODS: MCC-Spain is a multicase-control study that included 295 incident cases of gastric adenocarcinoma and 3040 controls. The association of the Western, Prudent, and Mediterranean dietary patterns-derived in another Spanish case-control study-with gastric adenocarcinoma was assessed using multivariable logistic regression models with random province-specific intercepts and considering a possible interaction with sex and age...
November 14, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29095488/antigastric-cancer-bioactive-aurantiochytrium-oil-rich-in-docosahexaenoic-acid-from-media-optimization-to-cancer-cells-cytotoxicity-assessment
#2
Shahryar Shakeri, Neda Amoozyan, Farzaneh Fekrat, Mahmood Maleki
Dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may have a role in contributing to the prevention or inhibition of some malignancies. DHA, the most important polyunsaturated fatty acid (PUFA) in fish and thraustochytrid oils, is known for its anticancer activity. However, antigastric cancer activity of thraustochytrid microbial oil is still unclear. In this investigation, 45 thraustochytrid strains were screened for the production of antigastric cancer oil. Cytotoxicity of 12 thraustochytrid oils was assessed by 3-(4,5-dimethythiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) on gastric cancer AGS cells...
November 2, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29061183/the-effects-of-epa-and-dha-enriched-fish-oil-on-nutritional-and-immunological-markers-of-treatment-na%C3%A3-ve-breast-cancer-patients-a-randomized-double-blind-controlled-trial
#3
Elemárcia Martins da Silva Paixão, Ana Carolina de M Oliveira, Nathalia Pizato, Maria Imaculada Muniz-Junqueira, Kelly G Magalhães, Eduardo Yoshio Nakano, Marina K Ito
BACKGROUND: We evaluated the effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids enriched fish oil (FO) on nutritional and immunological parameters of treatment naïve breast cancer patients. METHODS: In a randomized double blind controlled trial, the FO group (FG) patients were supplemented with 2 g/ day of FO concentrate containing 1.8 g of n-3 fatty acids during 30 days. The placebo group (PG) received 2 g/ day of mineral oil. At baseline and after the intervention, plasma levels of n-3 fatty acids, dietary intake, weight, body composition, biochemical and immunological markers were assessed...
October 23, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/29051441/the-food-and-beverage-occurrence-of-furfuryl-alcohol-and-myrcene-two-emerging-potential-human-carcinogens
#4
Alex O Okaru, Dirk W Lachenmeier
For decades, compounds present in foods and beverages have been implicated in the etiology of human cancers. The World Health Organization (WHO) International Agency for Research on Cancer (IARC) continues to classify such agents regarding their potential carcinogenicity in humans based on new evidence from animal and human studies. Furfuryl alcohol and β-myrcene are potential human carcinogens due to be evaluated. The major source of furfuryl alcohol in foods is thermal processing and ageing of alcoholic beverages, while β-myrcene occurs naturally as a constituent of the essential oils of plants such as hops, lemongrass, and derived products...
March 11, 2017: Toxics
https://www.readbyqxmd.com/read/29030414/longitudinal-associations-between-marine-omega-3-supplement-users-and-coronary-heart-disease-in-a-uk-population-based-cohort
#5
Marleen A H Lentjes, Ruth H Keogh, Ailsa A Welch, Angela A Mulligan, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw
OBJECTIVES: Assess the association between marine omega-3 polyunsaturated fatty acid (n-3 PUFA) intake from supplements, mainly cod liver oil, and coronary heart disease (CHD) mortality. DESIGN: Prospective cohort study, with three exposure measurements over 22 years. SETTING: Norfolk-based European Prospective Investigation into Cancer (EPIC-Norfolk, UK). PARTICIPANTS: 22 035 men and women from the general population, 39-79 years at recruitment...
October 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28842246/mediterranean-dietary-pattern-is-associated-to-low-risk-of-aggressive-prostate-cancer-mcc-spain-study
#6
Adela Castelló, Elena Boldo, Pilar Amiano, Gemma Castaño-Vinyals, Nuria Aragonés, Inés Gómez-Acebo, Rosana Peiró, Jose Juan Jimenez-Moleón, Juan Alguacil, Adonina Tardón, Lluís Cecchini, Virginia Lope, Trinidad Dierssen-Sotos, Lourdes Mengual, Manolis Kogevinas, Marina Pollán, Beatriz Pérez-Gómez
PURPOSE: To explore the association of the previously described Western, Prudent and Mediterranean dietary patterns with prostate cancer risk by tumor aggressiveness and extension. METHODS: MCC-Spain is a population-based multicase-control study, carried out in 7 Spanish provinces between September 2008 and December 2013. It collected anthropometric, epidemiologic and dietary information on 754 histologically confirmed incident cases of prostate cancer and 1277 controls aged 38 to 85 years...
August 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28832677/fish-oil-mitigates-myosteatosis-and-improves-chemotherapy-efficacy-in-a-preclinical-model-of-colon-cancer
#7
Alaa A Almasud, Kaitlin H Giles, John J Miklavcic, Karen J B Martins, Vickie E Baracos, Charles T Putman, Leluo L Guan, Vera C Mazurak
BACKGROUND: This study aimed to assess whether feeding a diet containing fish oil was efficacious in reducing tumor- and subsequent chemotherapy-associated myosteatosis, and improving tumor response to treatment. METHODS: Female Fischer 344 rats were fed either a control diet for the entire study (control), or switched to a diet containing fish oil (2.0 g /100 g of diet) one week prior to tumor implantation (long term fish oil) or at the start of chemotherapy (adjuvant fish oil)...
2017: PloS One
https://www.readbyqxmd.com/read/28781788/inhibition-of-pc3-human-prostate-cancer-cell-proliferation-invasion-and-migration-by-eicosapentaenoic-acid-and-docosahexaenoic-acid
#8
Keiichi Oono, Katsuya Takahashi, Saeka Sukehara, Hirohito Kurosawa, Tomio Matsumura, Shun'Ichiro Taniguchi, Shoichiro Ohta
The n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oil, exert a number of beneficial effects, and they are used in the treatment of hyperlipidemia. In recent years, EPA and DHA have been found to affect cancer cell proliferation. In the present study, PC3 cells, which are androgen-independent prostate cancer cells that resemble castration-resistant prostate cancer cells, were used to investigate a possible novel treatment for castration-resistant prostate cancer. The PC3 cells were cultured and incubated with various concentrations of EPA or DHA...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28770178/chemopreventive-and-chemotherapeutic-effects-of-fish-oil-derived-omega-3-polyunsaturated-fatty-acids-on-colon-carcinogenesis
#9
REVIEW
Ja Young Lee, Tae-Bu Sim, Jeong-Eun Lee, Hye-Kyung Na
Colorectal cancer is the third most common cause of cancer related death in the world. Multiple lines of evidence suggest that there is an association between consumption of dietary fat and colon cancer risk. Not only the amount but also the type and the ratio of fatty acids comprising dietary fats consumed have been implicated in the etiology and pathogenesis of colon cancer. Omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been known to inhibit development of colon cancer by downregulating the expression of genes involved in colon carcinogenesis and also by altering the membrane lipid composition...
July 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28725670/fatty-acid-and-lipidomic-data-in-normal-and-tumor-colon-tissues-of-rats-fed-diets-with-and-without-fish-oil
#10
Zora Djuric, Muhammad Nadeem Aslam, Becky R Simon, Ananda Sen, Yan Jiang, Jianwei Ren, Rena Chan, Tanu Soni, Thekkelnaycke M Rajendiran, William L Smith, Dean E Brenner
Data is provided to show the detailed fatty acid and lipidomic composition of normal and tumor rat colon tissues. Rats were fed either a Western fat diet or a fish oil diet, and half the rats from each diet group were treated with chemical carcinogens that induce colon cancer (azoxymethane and dextran sodium sulfate). The data show total fatty acid profiles of sera and of all the colon tissues, namely normal tissue from control rats and both normal and tumor tissues from carcinogen-treated rats, as obtained by gas chromatography with mass spectral detection...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28698478/antifungal-and-ichthyotoxic-sesquiterpenoids-from-santalum-album-heartwood
#11
Tae Hoon Kim, Tsutomu Hatano, Keinosuke Okamoto, Takashi Yoshida, Hiroshi Kanzaki, Michiko Arita, Hideyuki Ito
In our continuing study on a survey of biologically active natural products from heartwood of Santalum album (Southwest Indian origin), we newly found potent fish toxic activity of an n-hexane soluble extract upon primary screening using killifish (medaka) and characterized α-santalol and β-santalol as the active components. The toxicity (median tolerance limit (TLm) after 24 h at 1.9 ppm) of α-santalol was comparable with that of a positive control, inulavosin (TLm after 24 h at 1.3 ppm). These fish toxic compounds including inulavosin were also found to show a significant antifungal effect against a dermatophytic fungus, Trichophyton rubrum...
July 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28697730/dietary-supplementation-of-%C3%AE-linolenic-acid-induced-conversion-of-n-3-lcpufas-and-reduced-prostate-cancer-growth-in-a-mouse-model
#12
Jingjing Li, Zhennan Gu, Yong Pan, Shunhe Wang, Haiqin Chen, Hao Zhang, Wei Chen, Yong Q Chen
BACKGROUND: α-linolenic acid (ALA) is an n-3 polyunsaturated fatty acid (PUFA) and the substrate for long-chain n-3 PUFAs. The beneficial effects of ALA on chronic diseases are still in dispute, unlike those of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). METHODS: The primary objective of this investigation was to evaluate the efficiency of ALA uptake from a vegetable oil source and its subsequent conversion to n-3 long-chain PUFAs (LCPUFAs) in the tissues of growing mice, and to investigate its protective role in a prostate cancer animal model...
July 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28684736/fish-oil-enriched-nutrition-combined-with-systemic-chemotherapy-for-gastrointestinal-cancer-patients-with-cancer-cachexia
#13
Yumiko Shirai, Yoshinaga Okugawa, Asahi Hishida, Aki Ogawa, Kyoko Okamoto, Miki Shintani, Yuki Morimoto, Ryutaro Nishikawa, Takeshi Yokoe, Koji Tanaka, Hisashi Urata, Yuji Toiyama, Yasuhiro Inoue, Motoyoshi Tanaka, Yasuhiko Mohri, Ajay Goel, Masato Kusunoki, Donald C McMillan, Chikao Miki
Despite recent advances in chemotherapy for gastrointestinal cancer, a crucial factor related to poor prognosis is reduced tolerance to chemotherapy induced by cancer cachexia. Fish oil (FO)-derived eicosapentaenoic acid (EPA) modulates inflammation in patients with various malignancies; however, the impact of FO-enriched nutrition as a combined modality therapy on clinical outcomes remains controversial. We systemically analysed chronological changes in biochemical and physiological status using bioelectrical impedance analysis in 128 gastrointestinal cancer patients provided with or without FO-enriched nutrition during chemotherapy...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28673352/fish-oil-supplementation-and-insulin-sensitivity-a-systematic-review-and-meta-analysis
#14
Huanqing Gao, Tingting Geng, Tao Huang, Qinghua Zhao
BACKGROUND: Fish oil supplementation has been shown to be associated with a lower risk of metabolic syndrome and benefit a wide range of chronic diseases, such as cardiovascular disease, type 2 diabetes and several types of cancers. However, the evidence of fish oil supplementation on glucose metabolism and insulin sensitivity is still controversial. This meta-analysis summarized the exist evidence of the relationship between fish oil supplementation and insulin sensitivity and aimed to evaluate whether fish oil supplementation could improve insulin sensitivity...
July 3, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28666598/a-meta-analysis-of-n-3-polyunsaturated-fatty-acids-effects-on-circulating-acute-phase-protein-and-cytokines-in-gastric-cancer
#15
Michel C Mocellin, Ricardo Fernandes, Thayz R Chagas, Erasmo B S M Trindade
BACKGROUND & AIMS: Chronic inflammation is related with cancer and leads to worsening prognosis in cancer patients. n-3 polyunsaturated fatty acids (PUFAs) supplementation has been proposed as adjuvant treatment in cancer due anti-inflammatory properties. In the present meta-analysis, we pooled randomized clinical trials (RCTs) assessing the effects of n-3 PUFAs (from fish oil isolated or added in an immunonutrition formula) on inflammatory markers in gastric cancer. METHODS: A comprehensive literature search was performed in Medline, Scopus, Cochrane library, Science Direct and Web of Science, besides GOOGLE Scholar and a hand searching of reference lists, through July 2016...
May 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28659405/fish-oil-contaminated-with-persistent-organic-pollutants-induces-colonic-aberrant-crypt-foci-formation-and-reduces-antioxidant-enzyme-gene-expression-in-rats
#16
Mee Young Hong, Eunha Hoh, Brian Kang, Rebecca DeHamer, Jin Young Kim, Jan Lumibao
Background: Epidemiologic, clinical, and experimental studies have suggested that fish oil (FO), a rich source of n-3 (ω-3) polyunsaturated fatty acids, protects against colon cancer. However, this message is confounded by the FDA's warning that the consumption of certain types of fish should be restricted because of contamination with persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs) and organochlorine pesticides.Objective: We examined FO contaminated with POPs (PCBs, dichlorodiphenyltrichloroethane, and chlordane) compared with unmodified FO on the risk factors of colon cancer development...
August 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28633870/omega-3-free-fatty-acids-attenuate-insulin-promoted-breast-cancer-cell-proliferation
#17
Yang Guo, Sheng-Long Zhu, Yi-Kuan Wu, Zhao He, Yong-Quan Chen
High insulin levels in obese people are considered as a risk factor to induce breast carcinogenesis. And consumption of fish oils which mainly contain omega-3 fatty acids is associated with a reduced risk of breast cancer. However, whether omega-3 free fatty acids (FFAs) modulate insulin signaling pathway to prevent breast cancer is poorly understood. The current study tested the hypothesis that omega-3 FFAs attenuate insulin-induced breast cancer cell proliferation and regulate insulin signaling pathway. We show here that omega-3 FFAs attenuate MCF-7 cell proliferation and Akt and Erk1/2 phosphorylation levels stimulated by insulin...
June 2017: Nutrition Research
https://www.readbyqxmd.com/read/28586001/apoptosis-is-induced-by-docosahexaenoic-acid-in-breast-cancer-cells-via-death-receptor-and-mitochondria-mediated-pathways
#18
Meilan Xue, Yinlin Ge, Chundong Yu, Zheng Zheng, Xinjia He, Jinglan Zhao
In the present study, the antitumor effect of n‑3 fatty acid was evaluated, and the effect of docosahexaenoic acid (DHA) on the induction of apoptosis and its underlying mechanism were examined. Flow cytometry and western blot analysis were performed to analyze apoptosis and the expression of protein factors in human breast cancer cells. The data revealed that DHA inhibited the viability of MCF‑7 breast cancer cells in vitro, and promoted cell death by the induction of apoptosis. DHA decreased the expression of B‑cell lymphoma 2 (Bcl‑2), whereas the expression of Bcl‑2‑associated X protein was increased...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28578704/dietary-supplementation-with-n-3-fatty-acids-in-patients-with-pancreatic-cancer-and-cachexia-marine-phospholipids-versus-fish-oil-a-randomized-controlled-double-blind-trial
#19
Kristin Werner, Daniela Küllenberg de Gaudry, Lenka A Taylor, Tobias Keck, Clemens Unger, Ulrich T Hopt, Ulrich Massing
BACKGROUND: Like many other cancer patients, most pancreatic carcinoma patients suffer from severe weight loss. As shown in numerous studies with fish oil (FO) supplementation, a minimum daily intake of 1.5 g n-3-fatty acids (n-3-FA) contributes to weight stabilization and improvement of quality of life (QoL) of cancer patients. Given n-3-FA not as triglycerides (FO), but mainly bound to marine phospholipids (MPL), weight stabilization and improvement of QoL has already been seen at much lower doses of n-3-FA (0,3 g), and MPL were much better tolerated...
June 2, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28486571/ras-oncogene-and-hypoxia-inducible-factor-1-alpha-hif-1%C3%AE-expression-in-the-amazon-fish-colossoma-macropomum-cuvier-1818-exposed-to-benzo-a-pyrene
#20
Grazyelle Sebrenski da Silva, Luciana Mara Lopes Fé, Maria de Nazaré Paula da Silva, Vera Maria Fonseca de Almeida E Val
Benzo[a]pyrene (B[a]P) is a petroleum derivative capable of inducing cancer in human and animals. In this work, under laboratory conditions, we analyzed the responses of Colossoma macropomum to B[a]P acute exposure through intraperitoneal injection of four different B[a]P concentrations (4, 8, 16 and 32 μmol/kg) or corn oil (control group). We analyzed expression of the ras oncogene and the Hypoxia-inducible factor-1 alpha (hif-1α) gene using quantitative real-time PCR. Additionally, liver histopathological changes and genotoxic effects were evaluated through the comet assay...
April 2017: Genetics and Molecular Biology
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