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Fish oil and cancer

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https://www.readbyqxmd.com/read/28429921/relationship-between-dietary-patterns-and-brachial-ankle-pulse-wave-velocity-among-middle-aged-adults-in-japan
#1
Shota Moyama, Kazuhiro Minami, Mihiro Yano, Masumi Okumura, Susumu Hayashi, Hiroshi Takayama, Akira Yorimoto
BACKGROUND AND OBJECTIVES: Arterial stiffness is a leading cause of cardiovascular disease (CVD), and it is considered to be affected by dietary intake. However, few studies have examined the relationship between major dietary patterns and brachial-ankle pulse wave velocity (baPWV) among Japanese middle-aged subjects. We studied whether major dietary patterns were associated with baPWV in this population. METHODS AND STUDY DESIGN: Between 2009 and 2012, 70 Japanese middle-aged subjects (39 men and 31 women) with no history of stroke, coronary heart disease, or cancer were studied...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28427779/fish-oil-lc-pufas-do-not-affect-blood-coagulation-parameters-and-bleeding-manifestations-analysis-of-8-clinical-studies-with-selected-patient-groups-on-omega-3-enriched-medical-nutrition
#2
Stephanie Jeansen, Renger F Witkamp, Jossie A Garthoff, Ardy van Helvoort, Philip C Calder
BACKGROUND & AIMS: The increased consumption of fish oil enriched-products exposes a wide diversity of people, including elderly and those with impaired health to relatively high amounts of n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs). There is an ongoing debate around the possible adverse effects of n-3 LC-PUFAs on bleeding risk, particularly relevant in people with a medical history of cardiovascular events or using antithrombotic drugs. METHODS: This analysis of 8 clinical intervention studies conducted with enteral medical nutrition products containing fish oil as a source of n-3 LC-PUFAs addresses the occurrence of bleeding-related adverse events and effects on key coagulation parameters (Prothrombin Time [PT], (activated) and Partial Thromboplastin Time [(a)PTT])...
March 29, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28382280/anti-cancer-mechanism-of-docosahexaenoic-acid-in-pancreatic-carcinogenesis-a-mini-review
#3
REVIEW
Mirae Park, Hyeyoung Kim
Pancreatic cancer is a highly aggressive malignant tumor of the digestive system and radical resection, which is available to very few patients, might be the only possibility for cure. Since therapeutic choices are limited at the advanced stage, prevention is more important for reducing incidence in high-risk individuals with family history of pancreatic cancer. Epidemiological studies have shown that a high consumption of fish oil or ω3-polyunsaturated fatty acids reduces the risk of pancreatic cancers. Dietary fish oil supplementation has shown to suppress pancreatic cancer development in animal models...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28349837/apoptosis-mediated-chemosensitization-of-tumor-cells-to-5-fluorouracil-on-supplementation-of-fish-oil-in-experimental-colon-carcinoma
#4
Isha Rani, Bhoomika Sharma, Sandeep Kumar, Satinder Kaur, Navneet Agnihotri
5-Fluorouracil has been considered as a cornerstone therapy for colorectal cancer; however, it suffers from low therapeutic response rate and severe side effects. Therefore, there is an urgent need to increase the clinical efficacy of 5-fluorouracil. Recently, fish oil rich in n-3 polyunsaturated fatty acids has been reported to chemosensitize tumor cells to anti-cancer drugs. This study is designed to understand the underlying mechanisms of synergistic effect of fish oil and 5-fluorouracil by evaluation of tumor cell-associated markers such as apoptosis and DNA damage...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28330470/involvement-of-apoptotic-pathways-in-docosahexaenoic-acid-induced-benefit-in-prostate-cancer-pathway-focused-gene-expression-analysis-using-rt-2-profile-pcr-array-system
#5
Yanan Sun, Xiaopeng Jia, Lianguo Hou, Xing Liu, Qiang Gao
BACKGROUND: Present study aimed to better understand the potential apoptotic pathways that involved in docosahexaenoic acid (DHA)-induced apoptosis of prostate cancer cells. METHODS: Human prostate cancer DU145 cells were treated with different concentrations of fish oil, omega-3 PUFA (DHA, and Eicosapentaenoic acid, EPA), or omega-6 PUFA (Arachidonic acid, AA). Cell viability and apoptosis were evaluated by MTT assay and Hoechst staining. Pathway-focused gene expression profiling of DU145 cells was analyzed with the RT(2) Profile PCR Array System...
March 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28288429/human-health-risk-assessment-of-ddts-and-hchs-through-dietary-exposure-in-nanjing-china
#6
Qianqian Zhang, Zhonghuan Xia, Minmin Wu, Liping Wang, Hao Yang
In a market based study in Nanjing, a typical southeast city in China, the most common consumed 23 kinds of foods from eleven different categories (vegetable, fruit, fish, pork, livestock meat, chicken, egg, milk, oil, rice and flour) were sampled in November 2015. The concentrations of DDTs and HCHs in foods were analyzed using gas chromatography with mass spectrometer detector. The residual amounts of DDTs and HCHs in foods were 0.95-3.53 ng g(-1) and 0.32-1.96 ng g(-1), respectively. The highest residual of ∑10OCPs was 4...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28237087/e-configuration-structures-of-epa-and-dha-derived-from-euphausia-superba-and-their-significant-inhibitive-effects-on-growth-of-human-cancer-cell-lines-in-vitro
#7
Weilong Zheng, Xudong Wang, Wenjing Cao, Bowen Yang, Ying Mu, Yuesheng Dong, Zhilong Xiu
Many bioactive components such as poly-unsaturated fatty acids (e.g. EPA and DHA), phospholipids and astaxanthin are known in Antarctic krill (Euphausia superba) oil. The krill DHA and EPA are generally considered to be similar to natural ones. However, two chemical compounds which were separated from Antarctic krill oil and identified as EPA and DHA by HRESIMS and NMR acted much more effective inhibitive activities on growth of several cell lines (U937, K562, SMMC-7721, PC-3, MDA-MB-231, HL60 and MCF-7) than those from sturgeon liver and commercial fish oil...
February 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28178283/behavioral-risk-factors-of-breast-cancer-in-bangui-of-central-african-republic-a-retrospective-case-control-study
#8
Augustin Balekouzou, Ping Yin, Henok Kessete Afewerky, Cavin Bekolo, Christian Maucler Pamatika, Sylvain Wilfrid Nambei, Marceline Djeintote, Antoine Doui Doumgba, Christian Diamont Mossoro-Kpinde, Chang Shu, Minghui Yin, Zhen Fu, Tingting Qing, Mingming Yan, Jianyuan Zhang, Shaojun Chen, Hongyu Li, Zhongyu Xu, Boniface Koffi
Breast cancer is recognized as a major public health problem in developing countries; however, there is very little evidence of behavioral factors associated with breast cancer risk. This study was conducted to identify lifestyles as risk factors for breast cancer among Central African women. A case-control study was conducted with 174 cases confirmed histologically by the pathology unit of the National Laboratory and 348 age-matched controls. Data collection tools included a questionnaire with interviews and medical records of patients...
2017: PloS One
https://www.readbyqxmd.com/read/28111002/more-surprises-in-the-global-greenhouse-human-health-impacts-from-recent-toxic-marine-aerosol-formations-due-to-centennial-alterations-of-world-wide-coastal-food-webs
#9
REVIEW
J J Walsh, J M Lenes, R H Weisberg, L Zheng, C Hu, K A Fanning, R Snyder, J Smith
Reductions of zooplankton biomasses and grazing pressures were observed during overfishing-induced trophic cascades and concurrent oil spills at global scales. Recent phytoplankton increments followed, once Fe-, P-, and N-nutrient limitations of commensal diazotrophs and dinoflagellates were also eliminated by respective human desertification, deforestation, and eutrophication during climate changes. Si-limitation of diatoms instead ensued during these last anthropogenic perturbations of agricultural effluents and sewage loadings...
January 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28059952/atp-citrate-lyase-genetics-molecular-biology-and-therapeutic-target-for-dyslipidemia
#10
Amy C Burke, Murray W Huff
PURPOSE OF REVIEW: ATP-citrate lyase (ACLY) has re-emerged as a drug target for LDL cholesterol (LDL-C) lowering. We review ACLY as a therapeutic strategy, its genetics, its molecular and cellular biology, and also its inhibition. RECENT FINDINGS: ACLY is a critical enzyme linking glucose catabolism to lipogenesis by providing acetyl-CoA from mitochondrial citrate for fatty acid and cholesterol biosynthesis. Human genetic variants have been associated with enhanced growth and survival of several cancers, and with attenuated plasma triglyceride responses to dietary fish oil...
April 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/27990382/general-measures-and-quality-of-life-issues-in-psoriasis
#11
Rashmi Sarkar, Shikha Chugh, Shivani Bansal
Psoriasis generally does not affect survival but has significant detrimental effect on quality of life (QOL), which may be comparable to that of ischemic heart disease, diabetes, depression, and cancer. The foremost important thing in the management of psoriasis is counseling of the patient. The clinician needs to be empathetic and spend adequate time with the patient and educating the patient about psoriasis. Clinicians should make it clear to the patient that the primary goal of treatment is control of the disease rather than cure...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27785012/docosahexaenoic-acid-liposomes-for-targeting-chronic-inflammatory-diseases-and-cancer-an-in-vitro-assessment
#12
Amr Alaarg, Nan Yeun Jordan, Johan Jf Verhoef, Josbert M Metselaar, Gert Storm, Robbert J Kok
Inflammation, oxidative stress, and uncontrolled cell proliferation are common key features of chronic inflammatory diseases, such as atherosclerosis and cancer. ω3 polyunsaturated fatty acids (PUFAs; also known as omega3 fatty acids or fish oil) have beneficial effects against inflammation upon dietary consumption. However, these effects cannot be fully exploited unless diets are enriched with high concentrations of fish oil supplements over long periods of time. Here, a nanomedicine-based approach is presented for delivering effective levels of PUFAs to inflammatory cells...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27765796/early-life-residence-fish-consumption-and-risk-of-breast-cancer
#13
Alfheidur Haraldsdottir, Laufey Steingrimsdottir, Unnur A Valdimarsdottir, Thor Aspelund, Laufey Tryggvadottir, Tamara B Harris, Lenore J Launer, Lorelei A Mucci, Edward L Giovannucci, Hans-Olov Adami, Vilmundur Gudnason, Johanna E Torfadottir
Background: Little is known about fish intake throughout the life course and the risk of breast cancer.Methods: We used data on the first residence of 9,340 women born 1908 to 1935 in the Reykjavik Study as well as food frequency data for different periods of life from a subgroup of the cohort entering the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (n = 2,882).Results: During a mean follow-up of 27.3 years, 744 women were diagnosed with breast cancer in the Reykjavik Study. An inverse association of breast cancer was observed among women who lived through the puberty period in coastal villages, compared with women residing in the capital area [HR, 0...
March 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27646578/effects-of-%C3%AF-3-fatty-acids-and-catechins-on-fatty-acid-synthase-in-the-prostate-a-randomized-controlled-trial
#14
Zhenzhen Zhang, Mark Garzotto, Tomasz M Beer, Philippe Thuillier, Stephen Lieberman, Motomi Mori, Wesley A Stoller, Paige E Farris, Jackilen Shannon
Animal and human studies suggest fish oil and green tea may have protective effect on prostate cancer. Fatty acid synthase (FAS) has been hypothesized to be linked to chemoprotective effects of both compounds. This study evaluated the independent and joint effects of fish oil (FO) and green tea supplement (epigallocatechin-3-gallate, EGCG) on FAS and Ki-67 levels in prostate tissue. Through a double-blinded, randomized controlled trial with 2 × 2 factorial design, 89 men scheduled for repeat prostate biopsy following an initial negative prostate biopsy were randomized into either FO alone (1...
November 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27620176/novel-fish-oil-based-bigel-system-for-controlled-drug-delivery-and-its-influence-on-immunomodulatory-activity-of-imiquimod-against-skin-cancer
#15
Khurram Rehman, Mohd Hanif Zulfakar
PURPOSE: To characterize bigel system as a topical drug delivery vehicle and to establish the immunomodulatory role of imiquimod-fish oil combination against skin cancer and inflammation resulting from chemical carcinogenesis. METHODS: Imiquimod-loaded fish oil bigel colloidal system was prepared using a blend of carbopol hydrogel and fish oil oleogel. Bigels were first characterized for their mechanical properties and compared to conventional gel systems. Ex vivo permeation studies were performed on murine skin to analyze the ability of the bigels to transport drug across skin and to predict the release mechanism via mathematical modelling...
January 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/27576529/krill-oil-extract-suppresses-cell-growth-and-induces-apoptosis-of-human-colorectal-cancer-cells
#16
Abilasha Gayani Jayathilake, Paul Vincent Senior, Xiao Qun Su
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer in the world. The current available treatments for CRC include surgery, chemotherapy and radiotherapy. However, surgery is only useful when the disease is diagnosed at the earlier stage. Chemotherapy and radiotherapy are associated with numerous side effects that decrease the patients' quality of life. Safer, effective alternatives, such as natural compounds, to chemotherapy are desirable. This study assessed the efficacy of free fatty acid (FFA) extract of krill oil on three human CRC cells lines...
August 30, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27571113/suppression-of-nadph-oxidase-activity-may-slow-the-expansion-of-osteolytic-bone-metastases
#17
REVIEW
Mark F McCarty, James DiNicolantonio
Lysophosphatidic acid (LPA), generated in the microenvironment of cancer cells, can drive the proliferation, invasion, and migration of cancer cells by activating G protein-coupled LPA receptors. Moreover, in cancer cells that have metastasized to bone, LPA signaling can promote osteolysis by inducing cancer cell production of cytokines, such as IL-6 and IL-8, which can stimulate osteoblasts to secrete RANKL, a key promoter of osteoclastogenesis. Indeed, in cancers prone to metastasize to bone, LPA appears to be a major driver of the expansion of osteolytic bone metastases...
August 25, 2016: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/27548217/evidence-to-support-the-anti-cancer-effect-of-olive-leaf-extract-and-future-directions
#18
REVIEW
Anna Boss, Karen S Bishop, Gareth Marlow, Matthew P G Barnett, Lynnette R Ferguson
The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of cardiovascular disease and cancers. The main components of this diet include high intake of fruit, vegetables, red wine, extra virgin olive oil (EVOO) and fish, low intake of dairy and red meat. Olive oil has gained support as a key effector of health benefits and there is evidence that this relates to the polyphenol content. Olive leaf extract (OLE) contains a higher quantity and variety of polyphenols than those found in EVOO...
August 19, 2016: Nutrients
https://www.readbyqxmd.com/read/27546289/anti-inflammatory-effects-of-docosahexaenoic-acid-implications-for-its-cancer-chemopreventive-potential
#19
Hye-Won Yum, Hye-Kyung Na, Young-Joon Surh
The implication of inflammatory tissue damage in pathophysiology of human cancer as well as some metabolic disorders has been under intense investigation. Numerous studies have identified a series of critical signaling molecules involved in cellular responses to inflammatory stimuli. These include nuclear factor κB, peroxisome proliferator-activated receptor γ, nuclear factor erythroid 2 p45-related factor 2 and sterol regulatory element-binding protein 1. The proper regulation of these transcription factors mediating pro- and anti-inflammatory signaling hence provides an important strategy for the chemoprevention of inflammation-associated cancer...
October 2016: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/27527148/docosahexaenoic-acid-induces-oxidative-dna-damage-and-apoptosis-and-enhances-the-chemosensitivity-of-cancer-cells
#20
REVIEW
Eun Ah Song, Hyeyoung Kim
The human diet contains low amounts of ω-3 polyunsaturated fatty acids (PUFAs) and high amounts of ω-6 PUFAs, which has been reported to contribute to the incidence of cancer. Epidemiological studies have shown that a high consumption of fish oil or ω-3 PUFAs reduced the risk of colon, pancreatic, and endometrial cancers. The ω-3 PUFA, docosahexaenoic acid (DHA), shows anticancer activity by inducing apoptosis of some human cancer cells without toxicity against normal cells. DHA induces oxidative stress and oxidative DNA adduct formation by depleting intracellular glutathione (GSH) and decreasing the mitochondrial function of cancer cells...
August 3, 2016: International Journal of Molecular Sciences
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