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Selenium and cancer

Philippe Collery
Many experimental models demonstrated that inorganic and organic selenium (Se) compounds may have an anticancer activity. However, large clinical studies failed to demonstrate that Se supplementations may prevent the outcome of cancers. Moreover, there are few randomized trials in cancer patients and there is not yet any Se compound recognized as anticancer drug. There is still a need to develop new Se compounds with new strategies. For that, it may be necessary to consider that Se compounds may have a dual role, either as anti-oxidant or as pro-oxidant...
March 8, 2018: Journal of Trace Elements in Medicine and Biology
Yousef Zakharia, Arup Bhattacharya, Youcef M Rustum
Selenium (Se)-containing molecules exert antioxidant properties and modulate targets associated with tumor growth, metastasis, angiogenesis, and drug resistance. Prevention clinical trials with low-dose supplementation of different types of Se molecules have yielded conflicting results. Utilizing several xenograft models, we earlier reported that the enhanced antitumor activity of various chemotherapeutic agents by selenomethione and Se-methylselenocysteine in several human tumor xenografts is highly dose- and schedule-dependent...
February 13, 2018: Oncotarget
Mandy Schott, Miriam M de Jel, Julia C Engelmann, Philipp Renner, Edward K Geissler, Anja K Bosserhoff, Silke Kuphal
Selenium-binding protein 1 (SELENBP1) expression is reduced in various epithelial cancer entities compared to corresponding normal tissue and has already been described as a tumor suppressor involved in the regulation of cell proliferation, senescence, migration and apoptosis. We identified SELENBP1 to be down-regulated in cutaneous melanoma, a malignant cancer of pigment-producing melanocytes in the skin, which leads to the assumption that SELENBP1 also functions as tumor suppressor in the skin, as shown by others e...
February 13, 2018: Oncotarget
Mónica Álvarez-Pérez, Wesam Ali, Małgorzata Anna Marć, Jadwiga Handzlik, Enrique Domínguez-Álvarez
Selenium and selenocompounds have attracted the attention and the efforts of scientists worldwide due to their promising potential applications in cancer prevention and/or treatment. Different organic selenocompounds, with diverse functional groups that contain selenium, have been reported to exhibit anticancer and/or chemopreventive activity. Among them, selenocyanates, selenoureas, selenoesters, selenium-containing heterocycles, selenium nanoparticles, selenides and diselenides have been considered in the search for efficiency in prevention and treatment of cancer and other related diseases...
March 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jakub Lubiński, Wojciech Marciniak, Magdalena Muszynska, Ewa Jaworowska, Mieczyslaw Sulikowski, Anna Jakubowska, Katarzyna Kaczmarek, Grzegorz Sukiennicki, Michal Falco, Piotr Baszuk, Magdalena Mojsiewicz, Joanne Kotsopoulos, Ping Sun, Steven A Narod, Jan A Lubiński
[This corrects the article DOI: 10.1371/journal.pone.0184873.].
2018: PloS One
Anla Hu, Li Li, Chuanlai Hu, Daoming Zhang, Chen Wang, Yan Jiang, Meng Zhang, Chunmei Liang, Wenjun Chen, Qingli Bo, Qihong Zhao
Helicobacter pylori (H. pylori) infection can interfere with the absorption of most elements, and the variations of some element levels are related to the incidence of gastric cancer. However, there have been conflicting results concerning the influence of H. pylori infection on serum element levels. The present study aimed to compare the serum element concentrations of H. pylori-infected local residents with uninfected residents from Lujiang County with high gastric cancer risk in Eastern China. We used data and serum samples from the H...
March 3, 2018: Biological Trace Element Research
Dominika Mániková, Zuzana Šestáková, Jana Rendeková, Danuša Vlasáková, Patrícia Lukáčová, Edgars Paegle, Pavel Arsenyan, Miroslav Chovanec
Resveratrol is a natural (poly)phenol primarily found in plants protecting them against pathogens, as well as harmful effects of physical and chemical agents. In higher eukaryotic cells and organisms, this compound displays a remarkable range of biological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-aging, cardio- and neuro-protective properties. Here, biological activities of synthetic selenium-containing derivatives of resveratrol-benzo[ b ]selenophenes-have been studied in lower eukaryotes Saccharomyces cerevisiae ...
February 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Noelia Morales-Prieto, Julia Ruiz-Laguna, Nieves Abril
The toxicity of p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), a contaminant and metabolite derivative of DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] is partially mediated by reactive oxygen species. Protein cysteine-based regulatory switches and subsequent alterations of the overall hepatic metabolism are triggered by p,p'-DDE through the disruption of the cellular redox status. The consequences are reproductive impairment, metabolic disorders, diabetes, neurotoxicity and cancer. In recent years, the risk of p,p'-DDE exposure has increased worldwide, reflecting the rise of mosquito-borne diseases in tropical countries that produce and export contaminated foods...
February 23, 2018: Food and Chemical Toxicology
Gagan Chhabra, Chandra K Singh, Mary Ann Ndiaye, Samantha Fedorowicz, Arielle Molot, Nihal Ahmad
Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause of cancer-related deaths in American men. Due to its long latency period, PCa is considered as an ideal cancer type for chemopreventive interventions. Chemopreventive agents include various natural or synthetic agents that prevent or delay cancer development, progression and/or recurrence. Pre-clinical studies suggest that many natural products and dietary agents have chemopreventive properties. However, a limited number of these agents have been tested in clinical trials, with varying success...
February 19, 2018: Cancer Letters
Jamileh Abedi, Maedeh Vakili Saatloo, Vahid Nejati, Rahim Hobbenaghi, Amir Tukmechi, Yousef Nami, Ahmad Yari Khosroushahi
Colorectal cancer is one of the most common causes of mortality in the world while malnutrition is responsible for one third of the problem. Selenium has been recommended for prevention of colorectal cancer. The present study was conducted to investigate the effect of selenium-enriched Saccharomyces cerevisiae in reducing colorectal cancer progression in rats. Five groups of 170-200-g weight rats (n = 40) including healthy and cancer controls, Saccharomyces cerevisiae, selenium, and selenium-enriched Saccharomyces cerevisiae-treated groups were examined...
February 21, 2018: Biological Trace Element Research
Margaret P Rayman, Kristian Hillert Winther, Roberto Pastor-Barriuso, Frederick Cold, Marianne Thvilum, Saverio Stranges, Eliseo Guallar, Søren Cold
BACKGROUND: Selenium, an essential trace element, is incorporated into selenoproteins with a wide range of health effects. Selenoproteins may reach repletion at a plasma selenium concentration of ~125µg/L, at which point the concentration of selenoprotein P reaches a plateau; whether sustained concentrations higher than this are beneficial, or indeed detrimental, is unknown. OBJECTIVE: In a population of relatively low selenium status, we aimed to determine the effect on mortality of long-term selenium supplementation at different dose levels...
February 14, 2018: Free Radical Biology & Medicine
Hsiang Yu, Yu-Jen Cheng, Ching-Yun Wang
In multivariate recurrent event data regression, observation of recurrent events is usually terminated by other events that are associated with the recurrent event processes, resulting in informative censoring. Additionally, some covariates could be measured with errors. In some applications, an instrumental variable is observed in a subsample, namely a calibration sample, which can be applied for bias correction. In this article, we develop two non-parametric correction approaches to simultaneously correct for the informative censoring and measurement errors in the analysis of multivariate recurrent event data...
February 13, 2018: Biometrics
Bettina Genthe, Thandi Kapwata, Wouter Le Roux, Jessica Chamier, Caradee Y Wright
BACKGROUND: Anthropogenic pollution was identified as an environmental problem of concern when, in 2008, dozens of crocodiles died in the Olifants River catchment near the border of South Africa and Mozambique. Given the close proximity of households to the river and their making use of river water, we aimed to determine to what extent water pollution has an impact on health of indigent communities in South Africa and Mozambique in the catchment area. METHODS: Water and vegetable samples were collected from the study areas...
February 1, 2018: Chemosphere
Zijian Liu, Xiang Fu, Wei Huang, Chunxia Li, Xinyan Wang, Bei Huang
Selenium-containing phycocyanin (Se-PC) has been proved to have many biological effects, including anti-inflammatory and antioxidant. In this study, we investigated the photodynamic therapy (PDT) effects of Se-PC against liver tumour in vitro and in vivo experiment. Our results demonstrated that the half lethal dose of Se-PC PDT on HepG2 cells was 100μg/ml PC containing 20% selenium. Se-PC location migration from lysosomes to mitochondria was time dependent. In in vivo experiments, the tumour inhibition rate was 75...
December 20, 2017: Journal of Photochemistry and Photobiology. B, Biology
Debojyoti Moulick, Subhas Chandra Santra, Dibakar Ghosh
The south-east Asian countries are facing a serious threat of arsenic (As) toxicity due to extensive use of As contaminated groundwater for rice cultivation. This experiment was configured to assess the consequences of rice seed priming with selenium (Se) and cultivation in As free and As contaminated soil. The experiment was arranged in a factorial complete randomized design having two factors viz. seed priming and soil As stress with total twenty-five treatment combinations replicated thrice. Seed priming with Se promotes growth, yield under both As free and As stressed conditions...
January 25, 2018: Ecotoxicology and Environmental Safety
Paloma Begines, Ana Oliete, Óscar López, Inés Maya, Gabriela B Plata, José M Padrón, José G Fernández-Bolaños
AIM: The increasing number of cancer cases has stimulated researchers to seek for novel approaches. We have combined two bioactive moieties: a polyphenolic scaffold and an organoselenium motif. Four different families (isothiocyanates/thioureas, and their selenium isosters) derived from dopamine, (±)-norepinephrine and R-epinephrine were accessed. RESULTS: Heterocumulenes derived from dopamine and β-O-methylnoradrenaline were strong antiproliferative agents (GI50<10 μM)...
February 1, 2018: Future Medicinal Chemistry
Xueyang Fang, Chang'e Li, Lan Zheng, Fang Yang, Tianfeng Chen
A combination of chemotherapy and photothermal therapy has emerged as a promising tactic for cancer therapy. However, the intricacy of accurate delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle. Hence, to assure the chemotherapeutic drug and photothermal agent to be synchronously delivered to a tumor area to give play to their synergistic effect, the dual-target (RC-12 and PG-6 peptides) functionalized selenium nanoparticles loaded with both doxorubicin (DOX) and indocyanine green (ICG) were designed and successfully synthesized...
February 3, 2018: Chemistry, An Asian Journal
Fei-Hu Cui, Jing Chen, Zu-Yu Mo, Shi-Xia Su, Yan-Yan Chen, Xian-Li Ma, Hai-Tao Tang, Heng-Shan Wang, Ying-Ming Pan, Yan-Li Xu
A simple and efficient Cu-catalyzed decarboxylative/click reaction for the preparation of 1,4-disubstituted 5-arylselanyl-1,2,3-triazoles from propiolic acids, diselenides, and azides has been developed. The mechanistic study revealed that the intermolecular AAC reaction of an alkynyl selenium intermediate occurred. The resulting multisubstituted 5-seleno-1,2,3-triazoles were tested for in vitro anticancer activity by MTT assay, and compounds 4f, 4h, and 4p showed potent cancer cell-growth inhibition activities...
February 1, 2018: Organic Letters
Marco Vinceti, Tommaso Filippini, Cinzia Del Giovane, Gabriele Dennert, Marcel Zwahlen, Maree Brinkman, Maurice Pa Zeegers, Markus Horneber, Roberto D'Amico, Catherine M Crespi
BACKGROUND: This review is the third update of the Cochrane review "Selenium for preventing cancer". Selenium is a naturally occurring element with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancer. OBJECTIVES: To gather and present evidence needed to address two research questions:1. What is the aetiological relationship between selenium exposure and cancer risk in humans?2...
January 29, 2018: Cochrane Database of Systematic Reviews
Olga López-Guarnido, Noelia Urquiza-Salvat, Maria Saiz, David Lozano-Paniagua, Lourdes Rodrigo, Manrique Pascual-Geler, Jose Antonio Lorente, Maria Jesus Alvarez-Cubero, Ana Rivas
OBJECTIVE: The purpose of this review is to examine the evidence on the effects of bioactive constituents of the Mediterranean diet (MeDi) on prostate cancer (PCa) risk. METHODS: The search for articles came from extensive research in the following databases: PubMed, Scopus, and Web of Science. We used the search terms "Mediterranean diet," "lycopene," "vitamin E," "vitamin C," "Selenium," "resveratrol," "prostate cancer," and combinations, such as "lycopene and prostate cancer" or "resveratrol and prostate cancer...
January 27, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
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