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Selenium and cancer

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https://www.readbyqxmd.com/read/29330096/selenoprotein-h-controls-cell-cycle-progression-and-proliferation-of-human-colorectal-cancer-cells
#1
REVIEW
Martin Bertz, Katrin Kühn, Solveigh C Koeberle, Mike F Müller, Doerte Hoelzer, Karolin Thies, Stefanie Deubel, René Thierbach, Anna P Kipp
Selenoprotein H (SELENOH) is supposed to be involved in redox regulation as well as in tumorigenesis. However, its role in healthy and transformed cells of the gastrointestinal tract remains elusive. We analysed SELENOH expression in cells depending on their selenium supply and differentiation status and found that SELENOH expression was increased in tumor tissue, in undifferentiated epithelial cells from mice and in colorectal cancer lines as compared to more differentiated ones. Knockdown studies in human colorectal cancer cells revealed that repression of SELENOH decreased cellular differentiation and increased proliferation and migration...
January 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29324385/ameliorative-effects-of-selenium-on-arsenic-induced-cytotoxicity-in-pc12%C3%A2-cells-via-modulating-autophagy-apoptosis
#2
Md Mostafizur Rahman, Rachael A Uson-Lopez, Md Tajuddin Sikder, Gongxun Tan, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki
Arsenic is well known toxicant responsible for human diseases including cancers. On the other hand, selenium is an essential trace element with significant chemopreventive effects, anticancer potentials and antioxidant properties. Although previous studies have reported antagonism/synergism between arsenic and selenium in biological systems, the biomolecular mechanism/s is still inconclusive. Therefore, to elucidate the molecular phenomena in cellular level, we hypothesized that co-exposure of selenium with arsenic may have suppressive effects on arsenic-induced cytotoxicity...
December 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29317822/novel-functionalized-nanoparticles-for-tumor-targeting-co-delivery-of-doxorubicin-and-sirna-to-enhance-cancer-therapy
#3
Yu Xia, Tiantian Xu, Changbing Wang, Yinghua Li, Zhengfang Lin, Mingqi Zhao, Bing Zhu
Human homeobox protein (Nanog) is highly expressed in most cancer cells and has gradually emerged as an excellent target in cancer therapy, owing to its regulation of cancer cell proliferation, metastasis and apoptosis. In this study, we prepared tumor-targeting functionalized selenium nanoparticles (RGDfC-SeNPs) to load chemotherapeutic doxorubicin (DOX) and Nanog siRNA. Herein, RGDfC peptide was used as a tumor-targeting moiety which could specifically bind to αvβ3 integrins overexpressed on various cancer cells...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29314169/correlations-of-selenof-and-selenop-genotypes-with-serum-selenium-levels-and-prostate-cancer
#4
Dede N Ekoue, Emmanuel Ansong, Li Liu, Virgilia Macias, Ryan Deaton, Craig Lacher, Matthew Picklo, Larisa Nonn, Peter H Gann, Andre Kajdacsy-Balla, Gail S Prins, Vincent L Freeman, Alan M Diamond
BACKGROUND: Selenium status is inversely associated with the incidence of prostate cancer. However, supplementation trials have not indicated a benefit of selenium supplementation in reducing cancer risk. Polymorphisms in the gene encoding selenoprotein 15 (SELENOF) are associated with cancer incidence/mortality and present disproportionately in African Americans. Relationships among the genotype of selenoproteins implicated in increased cancer risk, selenium status, and race with prostate cancer were investigated...
January 5, 2018: Prostate
https://www.readbyqxmd.com/read/29305107/five-threads-how-u-shaped-thinking-weaves-together-dogs-men-selenium-and-prostate-cancer-risk
#5
REVIEW
David J Waters, Emily C Chiang
Prostate cancer is one of the leading causes of cancer-related mortality among men living in developed countries, making the development of safe, practical approaches to prostate cancer risk reduction a high research priority. The relationship between prostate cancer risk and selenium, an essential nutrient required for a number of metabolically important enzymes including glutathione peroxidases, has been investigated, but a satisfactory integration of results has proven elusive. Dogs, like men, naturally develop prostate cancer during aging, providing an appropriate context to study the effects of selenium supplementation on the dysregulation of homeostasis that drives cancer development within the aging prostate...
January 2, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29304040/serum-selenium-levels-and-the-risk-of-progression-of-laryngeal-cancer
#6
Jan Lubiński, Wojciech Marciniak, Magdalena Muszynska, Ewa Jaworowska, Mieczyslaw Sulikowski, Anna Jakubowska, Katarzyna Kaczmarek, Grzegorz Sukiennicki, Michal Falco, Piotr Baszuk, Magdalena Mojsiewicz, Joanne Kotsopoulos, Ping Sun, Steven A Narod, Jan A Lubiński
BACKGROUND: Observational studies have reported an inverse relationship between selenium status (blood or toenail) and the risk of laryngeal cancer; however, the impact of low serum selenium level on survival has not been evaluated. METHODS: We conducted a prospective study of 296 patients diagnosed with laryngeal cancer in Szczecin, Poland. Serum selenium was measured at diagnosis and prior to treatment. Patients were followed from the date of diagnosis to death at five years...
2018: PloS One
https://www.readbyqxmd.com/read/29301214/synthesis-of-selenium-quinone-hybrid-compounds-with-potential-antitumor-activity-via-rh-catalyzed-c-h-bond-activation-and-click-reactions
#7
Guilherme A M Jardim, Daisy J B Lima, Wagner O Valença, Daisy J B Lima, Bruno C Cavalcanti, Claudia Pessoa, Jamal Rafique, Antonio L Braga, Claus Jacob, Eufrânio N da Silva Júnior, Eduardo H G da Cruz
In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), SF295 (human glioblastoma cells), NCIH-460 (human lung cells) and PC3 (human prostate cancer cells). Some compounds showed good activity with IC50 values below 1 µM...
December 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29290051/protective-effects-of-selenium-on-cyclophosphamide-induced-oxidative-stress-and-kidney-injury
#8
Sibel Gunes, Varol Sahinturk, Sema Uslu, Adnan Ayhanci, Sedat Kacar, Ruhi Uyar
Cyclophosphamide (CP) is a common anticancer drug, but its use in cancer treatment is limited due to its severe toxicities induced mainly by oxidative stress in normal cells. Reactive oxygen species (ROS) lead to multiple organ injuries, including the kidneys. Selenium (Se) is a nutritionally essential trace element with antioxidant properties. In the present study, the possible protective effect of Se on CP-induced acute nephrotoxicity was investigated. Forty-two Sprague-Dawley rats were equally divided into six groups of seven rats in each...
December 30, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29288592/cancer-targeting-functionalization-of-selenium-containing-ruthenium-conjugate-with-tumor-microenvironment-responsive-property-to-enhance-theranostic-effects
#9
Zhennan Zhao, Pan Gao, Yuanyuan You, Tianfeng Chen
A mutifunctional ruthenium (Ru)-based conjugate Ru-BSe was designed and sythesized. The Ru complex with favorable bioimaging function was covalently linked with a cancer-targeted molecule that could be effectively internalized by the tumor to realize enhanced theranostic effects. The pH-response of the Ru conjugate in tumor acidic microenvironment causes ligand substitution and release of therapeutic complex. This activated complex remains inert to the reducing biomolecule-glutathione and terminally locates in mitochondria, where it triggers oxidative stress, and activates intrinsic apoptosis...
December 30, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29278740/the-a-to-z-of-modulated-cell-patterning-by-mammalian-thioredoxin-reductases
#10
REVIEW
Markus Dagnell, Edward E Schmidt, Elias S J Arnér
Mammalian thioredoxin reductases (TrxRs) are selenocysteine-containing proteins (selenoproteins) that propel a large number of functions through reduction of several substrates including the active site disulfide of thioredoxins (Trxs). Well-known enzymatic systems that in turn are supported by Trxs and TrxRs include deoxyribonucleotide synthesis through ribonucleotide reductase, antioxidant defense through peroxiredoxins and methionine sulfoxide reductases, and redox modulation of a number of transcription factors...
December 23, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29199570/selective-cytotoxic-activity-of-se-methyl-seleno-l-cysteine-and-se-polysaccharide-containing-extracts-from-shiitake-medicinal-mushroom-lentinus-edodes-agaricomycetes
#11
Marzenna Klimaszewska, Sandra Górska, Maciej Dawidowski, Piotr Podsadni, Agnieszka Szczepanska, Emilia Orzechowska, Dagmara Kurpios-Piec, Emilia Grosicka-Maciag, Iwonna Rahden-Staroń, Jadwiga Turło
Numerous formulations derived from the shiitake medicinal mushroom, Lentinus edodes, demonstrate anticancer activities. We hypothesized that isolates from selenium (Se)-enriched mycelia of L. edodes would possess stronger cancer-preventive properties than current preparations. The aim of this study was to investigate whether the presence of Se-methyl-seleno-L-cysteine in mycelial extracts of L. edodes affects their cytotoxic activity (makes them stronger) or whether they are as effective as Se-containing polysaccharides...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29189126/recent-advances-for-the-synthesis-of-selenium-containing-small-molecules-as-potent-antitumor-agents
#12
Qi Miao, Jinyi Xu, Aijun Lin, Xiaoming Wu, Liang Wu, Weijia Xie
Selenium-containing small molecules have attracted considerable attention of chemical and medicinal researchers owing to their various biological activities, such as antitumor effects, cardiovascular protection, antibacterial or antiviral effects, immunoregulation and nerve protection, among which the most promising area is antineoplasm. In the past several decades, different kinds of organoselenium compounds, such as selenides, seleno(iso)cyanates, substituted selenoureas, selenious esters and Se-containing heterocycles have been reported as candidates of anti-cancer agents...
November 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29187424/optimising-selenium-for-modulation-of-cancer-treatments
#13
REVIEW
Stephen Owen Evans, Puteri Farisa Khairuddin, Michael B Jameson
Selenium is an essential trace element involved in many biological processes that are mediated through, at least, 25 selenoproteins expressed in humans. Extensive study of selenium compounds has demonstrated growth inhibition of malignant cells in a vast array of experimental models. Moreover combining selenium with conventional cancer therapy has yielded promising results in both preclinical studies and a cohort of human trials. The aim of this review is to highlight the current research evaluating the role of selenium compounds in combination with chemotherapy and radiation...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29177363/self-assembled-selenium-nanoparticles-and-their-application-in-the-rapid-diagnostic-detection-of-small-cell-lung-cancer-biomarkers
#14
Yilin Zhao, Qiufeng Sun, Xi Zhang, Jan Baeyens, Haijia Su
By coupling molecular imprinting, chitosan biosorption and TiO2 photocatalysis, selenium nanoparticles (Se NPs) were self-assembled in a controlled manner on the molecular imprinting sites of zeolite-chitosan-TiO2 microspheres. Se NPs with different sizes and areal densities were individually synthesized by controlling the rapid adsorption of molecular-imprinted nanocomposites and photocatalytic reaction of TiO2 nanoparticles. In order to improve the sensitivity and specificity of rapid diagnostic detection, Se NPs were self-assembled again into high-order and spherically stable structures with an average size of 80 nm by well-defined monomer units, after separation from zeolite-chitosan-TiO2 microspheres with a stabilizer of 0...
November 27, 2017: Soft Matter
https://www.readbyqxmd.com/read/29176677/organoids-model-distinct-vitamin-e-effects-at-different-stages-of-prostate-cancer-evolution
#15
Rose N Njoroge, Kenji Unno, Jonathan C Zhao, Anum F Naseem, Jonathan F Anker, Warren A McGee, Larisa Nonn, Sarki A Abdulkadir
Vitamin E increased prostate cancer risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) through unknown mechanisms while Selenium showed no efficacy. We determined the effects of the SELECT supplements on benign (primary), premalignant ( RWPE-1) and malignant (LNCaP) prostate epithelial organoids. While the supplements decreased proliferation and induced cell death in cancer organoids, they had no effect on the benign organoids. In contrast, Vitamin E enhanced cell proliferation and survival in the premalignant organoids in a manner that recapitulated the SELECT results...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29176034/selenium-preserves-keratinocyte-stemness-and-delays-senescence-by-maintaining-epidermal-adhesion
#16
Lara Jobeili, Patricia Rousselle, David Béal, Eric Blouin, Anne-Marie Roussel, Odile Damour, Walid Rachidi
Skin is constantly exposed to environmental factors such as pollutants, chemicals and ultra violet radiation (UV), which can induce premature skin aging and increase the risk of skin cancer. One strategy to reduce the effect of oxidative stress produced by environmental exposure is the application of antioxidant molecules. Among the endogenous antioxidants, selenoproteins play a key role in antioxidant defense and in maintaining a reduced cellular environment. Selenium, essential for the activity of selenoproteins, is a trace element that is not synthesized by organisms and must be supplied by diet or supplementation...
November 25, 2017: Aging
https://www.readbyqxmd.com/read/29164198/aptamer-modified-selenium-nanoparticles-for-dark-field-microscopy-imaging-of-nucleolin
#17
Meng Li Liu, Hong Yan Zou, Chun Mei Li, Rong Sheng Li, Cheng Zhi Huang
Selenium nanoparticles (SeNPs) with strong green scattering light serving as light scattering nanoprobes for dark-field microscopy imaging are developed for the first time. The SeNPs show good stability, excellent biocompatibility, and high light-producing power, and can precisely and specifically target cancer cells with overexpressed nucleolin (NCL) after modification with aptamers, revealing that the SeNPs can act as a good light scattering nanoprobe for bioimaging and biolabeling.
November 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29147526/a-ratiometric-fluorescent-probe-for-imaging-and-quantifying-anti-apoptotic-effects-of-gsh-under-temperature-stress
#18
Xiaoyue Han, Xinyu Song, Fabiao Yu, Lingxin Chen
Hypothermia and hyperthermia are cell stressed states resulting from environmental temperature changes, which can abnormally decrease intracellular glutathione (GSH) concentrations and induce apoptosis. As the most abundant intracellular non-protein biothiol, GSH can protect cells from apoptosis. Considering the important roles of GSH in the anti-apoptotic process in cells and in vivo, we strive to develop a powerful chemical tool for the direct detection of GSH concentration changes under temperature stress...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29140592/a-versatile-strategy-to-main-chain-sulfur-selenium-functionalized-polycarbonates-via-macro-ring-closure-of-diols-and-subsequent-ring-opening-polymerization
#19
Chao Wei, Yan Zhang, Bingkun Yan, Yue Xu, Zhengzhen Du, Meidong Lang
Sulfur/selenium containing cyclic carbonate monomers (MR) are designed and synthesized by enzyme catalyzed intermolecular macro-ring closure of related diols. The proposed synthetic strategy is tolerant of other functionalities such as N-substituted groups. The ring opening polymerization (ROP) of MR occurs readily as a versatile route to generate a new family of main chain sulfur/selenium substituted aliphatic polycarbonates (PR) with predictable molecular weights (MW), narrow molecular-weight distribution and controlled copolymer composition...
November 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29129231/the-association-between-the-index-of-nutritional-quality-inq-and-breast-cancer-and-the-evaluation-of-nutrient-intake-of-breast-cancer-patients-a-case-control-study
#20
Farhad Vahid, Mahshid Hatami, Mahya Sadeghi, Fatemeh Ameri, Zeinab Faghfoori, Sayed Hossein Davoodi
OBJECTIVE: Breast cancer (BrCa) is the most frequently diagnosed cancer among females and second cancer after lung cancer in many societies. In Iran, the risk for BrCa is 1 in 35 and each year, 8000 new patients have been diagnosed with BrCa. Studies have shown that dietary components are implicated in the etiology of BrCa. The Index of Nutritional Quality (INQ) is a method of quantitative and qualitative analysis of single foods, meals, and diets. The aim of this study was to determine the usefulness of INQs in predicting BrCa risk...
January 2018: Nutrition
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