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Selenium and cancer

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https://www.readbyqxmd.com/read/28718286/functionalized-selenium-nanosystem-as-radiation-sensitizer-of-125i-seeds-for-precise-cancer-therapy
#1
Yahui Yang, Qiang Xie, Zhennan Zhao, Lizhen He, Leung Chan, Yingxiang Liu, Yongle Chen, Mingjun Bai, Tao Pan, Yanni Qu, Long Ling, Tianfeng Chen
Although radiotherapy has been extensively applied in cancer treatment, external beam radiation therapy is still difficult to avoid damage to adjacent normal tissues in the process of delivering a sufficient radiation dose to the tumor sites of patients. To overcome this limitation, chemoradiotherapy, as a combination of chemotherapy and radiotherapy of radioactive seed, has been proposed to decrease the damage for tumor surrounding tissues and enhance the radiosensitivity of solid tumors. In the study, we designed and synthesized folic acid-conjugated selenium nanoparticles (FA@SeNPs) as cancer-targeting agent, which could be synergistically enhanced by the radioactive 125I seeds to realize anticancer efficacy and inhibited colony formation ability...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28714901/selenium-containing-polysaccharide-protein-complex-in-se-enriched-ulva-fasciata-induces-mitochondria-mediated-apoptosis-in-a549-human-lung-cancer-cells
#2
Xian Sun, Yu Zhong, Hongtian Luo, Yufeng Yang
The role of selenium (Se) and Ulva fasciata as potent cancer chemopreventive and chemotherapeutic agents has been supported by epidemiological, preclinical, and clinical studies. In this study, Se-containing polysaccharide-protein complex (Se-PPC), a novel organoselenium compound, a Se-containing polysaccharide-protein complex in Se-enriched Ulva fasciata, is a potent anti-proliferative agent against human lung cancer A549 cells. Se-PPC markedly inhibited the growth of cancer cells via induction of apoptosis which was accompanied by the formation of apoptotic bodies, an increase in the population of apoptotic sub-G1 phase cells, upregulation of p53, and activation of caspase-3 in A549 cells...
July 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28685585/the-effects-of-combined-selenium-nanoparticles-and-radiation-therapy-on-breast-cancer-cells-in-vitro
#3
Feng Chen, Xiao Hong Zhang, Xiao Dan Hu, Pei Dang Liu, Hai Qian Zhang
Radiosensitizers that increase cancer cell radio-sensitivity can enhance the effectiveness of irradiation and minimize collateral damage. Nanomaterial has been employed in conjunction with radiotherapy as radiosensitizers, due to its unique physicochemical properties. In this article, we evaluated selenium nanoparticles (Nano-Se) as a new radiosensitizer. Nano-Se was used in conjunction with irradiation on MCF-7 breast cancer cells, and efficacy and mechanisms of this combined treatment approach were evaluated...
July 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28684913/preparation-and-antioxidant-properties-of-selenium-nanoparticles-loaded-chitosan-microspheres
#4
Kaikai Bai, Bihong Hong, Jianlin He, Zhuan Hong, Ran Tan
Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded chitosan microspheres (SeNPs-M). The physicochemical properties including morphology, elemental state, size distribution and surface potential were investigated...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28681438/selenium-and-breast-cancer-risk-a-prospective-nested-case-control-study-on-serum-selenium-levels-smoking-habits-and-overweight
#5
Malte Sandsveden, Jonas Manjer
Previous research has not been conclusive regarding the association between selenium (Se) and breast cancer. This study was conducted to clarify if there is an association between prediagnostic serum Se levels and breast cancer risk. A population based cohort, the Malmö Diet and Cancer Study, was used and linked with the Swedish cancer registry up to 31 December 2013. Our study included 1186 women with breast cancer and an equal number of controls. Selenium levels were analysed from stored serum samples. The included individuals were divided into quartiles based on Se value and we compared breast cancer cases with controls using logistic regression yielding odds ratios (OR) with 95% confidence intervals...
July 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28680742/modulation-of-mhc-class-i-surface-expression-in-b16f10-melanoma-cells-by-methylseleninic-acid
#6
Claudia Lennicke, Jette Rahn, Jürgen Bukur, Falko Hochgräfe, Ludger A Wessjohann, Rudolf Lichtenfels, Barbara Seliger
The essential trace element selenium (Se) might play a role in cancer prevention as well as for cancer therapy. Its metabolite methylselenol is able to kill cells through distinct mechanisms including induction of reactive oxygen species, DNA damage and apoptosis. Since methylselenol affects innate immune responses by modulating the expression of NKG2D ligands, the aim of this study was to determine whether the methylselenol generating compound methylseleninic acid (MSA) influences the expression of the MHC class I surface antigens and growth properties thereby reverting immune escape...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28672782/vitamin-e-and-alzheimer-s-disease-is-it-time-for-personalized-medicine
#7
REVIEW
Breana Cervantes, Lynn M Ulatowski
For the last two decades, it has been hotly debated whether vitamin E-the major lipid-soluble antioxidant, which functions to maintain neurological integrity-is efficacious as a therapy for Alzheimer's disease. Several factors key to the debate, include (1) which of the eight naturally-occurring vitamin E forms should be used; (2) how combination treatments affect vitamin E efficacy; and (3) safety concerns that most-recently resurfaced after the results of the Selenium and vitamin E Cancer prevention trial SELECT prostate cancer trial...
June 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28657651/diet-and-cancer-prevention-dietary-compounds-dietary-micrornas-and-dietary-exosomes
#8
Zarrin Banikazemi, Hemat Aghagolzadeh Haji, Mohsen Mohammadi, Gholamreza Taheripak, Elmira Iranifar, Mohsen Poursadeghiyan, Abdullah Moridikia, Bahman Rashidi, Mohsen Taghizadeh, Hamed Mirzaei
Cancer is one of main health public problems worldwide. Several factors are involved in beginning and development of cancer. Genetic and internal/external environmental factors can be as important agents that effect on emerging and development of several cancers. Diet and nutrition may be as one of important factors in prevention or treatment of various cancers. A large number studies indicated that suitable dietary patterns may help to cancer prevention or could inhibit development of tumor in cancer patients...
June 28, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28640579/rapid-and-robust-quantification-of-p-xyleneselenocyanate-in-plasma-via-derivatization
#9
Wenyi Zheng, Fadwa Benkessou, Brigitte Twelkmeyer, Siyao Wang, Tobias Ginman, Håkan Ottosson, Manuchehr Abedi-Valugerdi, Maria Angels Subirana, Ying Zhao, Moustapha Hassan
p-Xyleneselenocyanate (p-XSC) is one of the most investigated selenium compounds in cancer-prevention and -therapy. Despite the potent anticancer property, there is still no proper method to perform the quantitative analysis of p-XSC in plasma. In this investigation, we aimed at developing a method based on liquid chromatography-mass spectrometry (LC-MS) for the measurement of p-XSC in plasma. Direct deproteinization was first used to extract parent p-XSC from plasma, but failed to achieve high recovery rate (<2%) due to formation of selenium-sulfur bond between p-XSC and plasma protein...
July 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28634111/levels-of-plasma-selenium-and-urinary-total-arsenic-interact-to-affect-the-risk-for-prostate-cancer
#10
Yu-Mei Hsueh, Chien-Tien Su, Horng-Sheng Shiue, Wei-Jen Chen, Yeong-Shiau Pu, Ying-Chin Lin, Cheng-Shiuan Tsai, Chao-Yuan Huang
This study investigated whether plasma selenium levels modified the risk for prostate cancer (PC) related to arsenic exposure. We conducted a case-control study that included 318 PC patients and 318 age-matched, healthy control subjects. Urinary arsenic profiles were examined using HPLC-HG-AAS and plasma selenium levels were measured by ICP-MS. We found that plasma selenium levels displayed a significant dose-dependent inverse association with PC. The odds ratio (OR) and 95% confidence interval (CI) for PC was 0...
June 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28630379/the-association-between-telomere-length-and-mortality-in-bangladesh
#11
Samantha G Dean, Chenan Zhang, Jianjun Gao, Shantanu Roy, Justin Shinkle, Mekala Sabarinathan, Maria Argos, Lin Tong, Alauddin Ahmed, Md Tariqul Islam, Tariqul Islam, Muhammad Rakibuz-Zaman, Golam Sarwar, Hasan Shahriar, Mahfuzar Rahman, Md Yunus, Joseph H Graziano, Lin S Chen, Farzana Jasmine, Muhammad G Kibriya, Habibul Ahsan, Brandon L Pierce
Telomeres are tandem repeat sequences at the end of chromosomes that bind proteins to protect chromosome ends. Telomeres shorten with age, and shorter leukocyte telomere length (TL) has been associated with overall mortality in numerous studies. However, this association has not been tested in populations outside of Europe and the U.S. We assessed the association between TL and subsequent mortality using data on 744 mortality cases and 761 age-/sex-matched controls sampled from >27,000 participants from three longitudinal Bangladeshi cohorts: Health Effects of Arsenic Longitudinal Study (HEALS), HEALS Expansion (HEALS-E), and Bangladesh Vitamin E and Selenium Trial (BEST)...
June 15, 2017: Aging
https://www.readbyqxmd.com/read/28592284/biogenic-selenium-nanoparticles-induce-ros-mediated-necroptosis-in-pc-3-cancer-cells-through-tnf-activation
#12
Praveen Sonkusre, Swaranjit Singh Cameotra
BACKGROUND: Selenium is well documented to inhibit cancer at higher doses; however, the mechanism behind this inhibition varies widely depending on the cell type and selenium species. Previously, we have demonstrated that Bacillus licheniformis JS2 derived biogenic selenium nanoparticles (SeNPs) induce non-apoptotic cell death in prostate adenocarcinoma cell line, PC-3, at a minimal concentration of 2 µg Se/ml, without causing toxicity to the primary cells. However, the mechanism behind its anticancer activity was elusive...
June 7, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28586725/cadmium-arsenic-selenium-and-iron-implications-for-tumor-progression-in-breast-cancer
#13
E Jablonska, K Socha, E Reszka, E Wieczorek, J Skokowski, L Kalinowski, W Fendler, B Seroczynska, M Wozniak, M H Borawska, W Wasowicz
The aim of this study was to determine Cd (cadmium) and As (arsenic) contents in human breast cancer tissues, investigate their interactions with Se (selenium) and Fe (iron), and assess their further implications for tumor progression. Metal contents were determined in 42 tissue sets (tumor and adjacent tissue) collected from 42 women diagnosed with primary breast cancer. Analytical methods included AAS and ICP-MS techniques. Significantly higher contents of Cd (p=0.0003), Se (p<0.0001) and Fe (p=0.0441) whereas significantly lower content of As (p<0...
July 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28571588/expression-profiling-indicating-low-selenium-sensitive-microrna-levels-linked-to-cell-cycle-and-cell-stress-response-pathways-in-the-caco-2-cell-line
#14
Mark J McCann, Kunjana Rotjanapun, John E Hesketh, Nicole C Roy
Se is an essential micronutrient for human health, and fluctuations in Se levels and the potential cellular dysfunction associated with it may increase the risk for disease. Although Se has been shown to influence several biological pathways important in health, little is known about the effect of Se on the expression of microRNA (miRNA) molecules regulating these pathways. To explore the potential role of Se-sensitive miRNA in regulating pathways linked with colon cancer, we profiled the expression of 800 miRNA in the CaCo-2 human adenocarcinoma cell line in response to a low-Se (72 h at <40 nm) environment using nCounter direct quantification...
June 2, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28551014/lead-selenium-and-nickel-concentrations-in-epithelial-ovarian-cancer-borderline-ovarian-tumor-and-healthy-ovarian-tissues
#15
Emel Canaz, Metin Kilinc, Hamide Sayar, Gurkan Kiran, Eser Ozyurek
OBJECTIVE: Wide variation exists in ovarian cancer incidence rates suggesting the importance of environmental factors. Due to increasing environmental pollution, trace elements and heavy metals have drawn attention in studies defining the etiology of cancer, but scant data is available for ovarian cancer. Our aim was to compare the tissue concentrations of lead, selenium and nickel in epithelial ovarian cancer, borderline tumor and healthy ovarian tissues. METHODS: The levels of lead, selenium and nickel were estimated using atomic absorption spectrophotometry in formalin-fixed paraffin-embedded tissue samples...
September 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28499854/curcumin-loading-potentiates-the-chemotherapeutic-efficacy-of-selenium-nanoparticles-in-hct116-cells-and-ehrlich-s-ascites-carcinoma-bearing-mice
#16
Manisha Kumari, L Ray, M P Purohit, S Patnaik, A B Pant, Y Shukla, P Kumar, K C Gupta
The anticancer properties of selenium (Se) and curcumin nanoparticles in solo formulations as well as in combination with other therapeutic agents have been proved time and again. Exploiting this facet of the two, we clubbed their tumoricidal characteristics and designed curcumin loaded Se nanoparticles (Se-CurNPs) to achieve an enhanced therapeutic effect. We evaluated their therapeutic effects on different cancer cell lines and Ehrlich's ascites carcinoma mouse model. In vitro results showed that Se-CurNPs were most effective on colorectal carcinoma cells (HCT116) compared to the other cancer cell lines used and possessed pleiotropic anticancer effects...
May 9, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28495429/superoxide-hydrogen-peroxide-genetic-imbalance-modulates-differentially-the-oxidative-metabolism-on-human-peripheral-blood-mononuclear-cells-exposed-to-seleno-l-methionine
#17
Karen Lilian Schott, Charles Elias Assmann, Fernanda Barbisan, Verônica Farina Azzolin, Beatriz Bonadiman, Marta Maria Medeiros Frescura Duarte, Alencar Kolinski Machado, Ivana Beatrice Mânica da Cruz
Superoxide-hydrogen peroxide (S-HP) imbalance genetically caused by a gene polymorphism in the human manganese superoxide dismutase enzyme (Val16Ala-MnSOD) is associated with several diseases. Into mitochondria, MnSOD catalyses superoxide radical producing HP and oxygen. Ala-MnSOD genotype presents a high MnSOD efficiency and generates the highest HP concentrations that has been associated with the risk of several cancer types. Cellular selenoenzymes glutathione peroxidase and thioredoxin reductase (TrxR) and catalase (CAT) are essential to HP removal produced in excess in cells...
May 8, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28460158/designing-core-shell-gold-and-selenium-nanocomposites-for-cancer-radiochemotherapy
#18
Yanzhou Chang, Lizhen He, Zhibin Li, Lilan Zeng, Zhenhuan Song, Penghui Li, Leung Chan, Yuanyuan You, Xue-Feng Yu, Paul K Chu, Tianfeng Chen
Radiotherapy is an important regime for treating malignant tumors. There is interest in the development of radiosensitizers to increase the local treatment efficacy under a relatively low and safe radiation dose. In this study, we designed Au@Se-R/A nanocomposites (Au@Se-R/A NCs) as nano-radiosensitizer to realize synergistic radiochemotherapy based on the radiotherapy sensitization property of Au nanorods (NRs) and antitumor activity of Se NPs. In vitro studies show that the combined treatment of A375 melanoma cells in culture with NCs and X-ray induces cell apoptosis through alteration in expression of p53 and DNA-damaging genes and triggers intracellular ROS overproduction, leading to greatly enhanced anticancer efficacy...
May 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28454412/comparison-of-the-seleno-transcriptome-expression-between-human-non-cancerous-mammary-epithelial-cells-and-two-human-breast-cancer-cell-lines
#19
Fabiola Rusolo, Francesca Capone, Raffaella Pasquale, Antonella Angiolillo, Giovanni Colonna, Giuseppe Castello, Maria Costantini, Susan Costantini
Breast cancer is the second most common cause of mortality in women; therefore, the identification of novel putative markers is required to improve its diagnosis and prognosis. Selenium is known to protect mammary epithelial cells from oxidative DNA damage, and to inhibit the initiation phase of carcinogenesis by stimulating DNA repair and apoptosis regulation. Consequently, the present study has focused attention on the selenoprotein family and their involvement in breast cancer. The present study performed a global analysis of the seleno-transcriptome expression in human breast cancer MCF-7 and MDA-MB231 cell lines compared with healthy breast MCF-10A cells using reverse transcription-quantitative polymerase chain reaction...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28440710/selenium-nanoparticles-potential-in-cancer-gene-and-drug-delivery
#20
Fiona Maiyo, Moganavelli Singh
In recent decades, colloidal selenium nanoparticles have emerged as exceptional selenium species with reported chemopreventative and therapeutic properties. This has sparked widespread interest in their use as a carrier of therapeutic agents with results displaying synergistic effects of selenium with its therapeutic cargo and improved anticancer activity. Functionalization remains a critical step in selenium nanoparticles' development for application in gene or drug delivery. In this review, we highlight recent developments in the synthesis and functionalization strategies of selenium nanoparticles used in cancer drug and gene delivery systems...
May 2017: Nanomedicine
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