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Selenium and cancer

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https://www.readbyqxmd.com/read/27908419/selenium-levels-in-human-breast-carcinoma-tissue-are-associated-with-a-common-polymorphism-in-the-gene-for-selenop-selenoprotein-p
#1
Dede N Ekoue, Sofia Zaichick, Klara Valyi-Nagy, Matthew Picklo, Craig Lacher, Kent Hoskins, Michael A Warso, Marcelo G Bonini, Alan M Diamond
Selenium supplementation of the diets of rodents has consistently been shown to suppress mammary carcinogenesis and some, albeit not all, human epidemiological studies have indicated an inverse association between selenium and breast cancer risk. In order to better understand the role selenium plays in breast cancer, 30 samples of tumor tissue were obtained from women with breast cancer and analyzed for selenium concentration, the levels of several selenium-containing proteins and the levels of the MnSOD anti-oxidant protein...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27903840/evaluation-of-antioxidant-intakes-in-relation-to-inflammatory-markers-expression-within-the-normal-breast-tissue-of-breast-cancer-patients
#2
Danielle Larouche, Mirette Hanna, Sue-Ling Chang, Simon Jacob, Bernard Têtu, Caroline Diorio
Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tissue. We aimed to evaluate correlations between antioxidant (vitamin A/retinol, vitamin C, vitamin E, β-carotene, α-carotene, lycopene, lutein/zeaxanthin, β-cryptoxanthin, selenium, and zinc) intakes and protein expression levels of interleukin (IL)-6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase-2, leptin, serum amyloid A1, signal transducer and activator of transcription 3, IL-8, IL-10, lactoferrin, and transforming growth factor-β measured in the normal breast tissue of 160 women diagnosed with breast cancer...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27895876/assessment-of-mean-glandular-dose-in-mammography-system-with-different-anode-filter-combinations-using-mcnp-code
#3
Lida Gholamkar, Ali Asghar Mowlavi, Mahdi Sadeghi, Mitra Athari
BACKGROUND: X-ray mammography is one of the general methods for early detection of breast cancer. Since glandular tissue in the breast is sensitive to radiation and it increases the risk of cancer, the given dose to the patient is very important in mammography. OBJECTIVES: The aim of this study was to determine the average absorbed dose of X-ray radiation in the glandular tissue of the breast during mammography examinations as well as investigating factors that influence the mean glandular dose (MGD)...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27866615/anti-neoplastic-selenium-nanoparticles-from-idiomarina-sp-pr58-8
#4
Pallavee Srivastava, Meenal Kowshik
Selenium nanoparticles (SeNPs) with novel biological activities, cancer cell selectivity, and low toxicity towards normal cells have gained attention for chemo-therapeutic and chemo-preventive applications. These nanoparticles may be synthesized using micro-organisms, which is the green alternative of nanofabrication. Here we report the intracellular synthesis of SeNPs by the moderate halophilic bacterium, Idiomarina sp. PR58-8 using sodium selenite as the precursor. Characterization of SeNPs by XRD exhibited the characteristic Bragg's peak of hexagonal selenium with a crystallite domain size of 34nm...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27865619/inhibition-on-the-growth-of-human-mda-mb-231-breast-cancer-cells-in-vitro-and-tumor-growth-in-a-mouse-xenograft-model-by-se-containing-polysaccharides-from-pyracantha-fortuneana
#5
Chengfu Yuan, Changdong Wang, Junjie Wang, Vikas Kumar, Firoz Anwar, Fangxiang Xiao, Gohar Mushtaq, Yufei Liu, Mohammad Amjad Kamal, Ding Yuan
Breast cancer is the second cause of cancer-related death among Women. Current therapies for breast cancer have adverse side-effects. Selenium (Se)-containing polysaccharides have multiple health benefits to humans. Pyracantha fortuneana (P. fortuneana) contains rich Se polysaccharides. We hypothesized that Se-containing polysaccharides from P. fortuneana possess anticancer activity on breast cancer via inhibiting growth and inducing apoptosis. This study aimed to assess the anticancer effect of Se-containing polysaccharides from P...
October 2, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27863332/combined-effect-of-aerobic-interval-training-and-selenium-nanoparticles-on-expression-of-il-15-and-il-10-tnf-%C3%AE-ratio-in-skeletal-muscle-of-4t1-breast-cancer-mice-with-cachexia
#6
M Molanouri Shamsi, S Chekachak, S Soudi, L S Quinn, K Rangbar, J Chenari, M H Yazdi, M Mahdavi
Cancer cachexia is characterized by inflammation, loss of skeletal muscle and adipose tissue mass, and functional impairment. Oxidative stress and inflammation are believed to regulate pathways controlling skeletal muscle wasting. The aim of this study was to determine the effects of aerobic interval training and the purported antioxidant treatment, selenium nanoparticle supplementation, on expression of IL-15 and inflammatory cytokines in 4T1 breast cancer-bearing mice with cachexia. Selenium nanoparticle supplementation accelerated cachexia symptoms in tumor-bearing mice, while exercise training prevented muscle wasting in tumor-bearing mice...
November 15, 2016: Cytokine
https://www.readbyqxmd.com/read/27859272/dietary-trace-element-intake-and-liver-cancer-risk-results-from-two-population-based-cohorts-in-china
#7
Xiao Ma, Yang Yang, Hong-Lan Li, Wei Zheng, Jing Gao, Wei Zhang, Gong Yang, Xiao-Ou Shu, Yong-Bing Xiang
Dietary factors have been hypothesized to affect the risk of liver cancer via various mechanisms, but the influence has been not well studied and the evidence is conflicting. We investigated associations of dietary trace element intake, assessed through a validated food frequency questionnaire, with risk of liver cancer in two prospective cohort studies of 132,765 women (1997-2013) and men (2002-2013) in Shanghai, China. The associations were first evaluated in cohort studies and further assessed in a case-control study nested within these cohorts adjusting for hepatitis B virus infection...
November 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27856111/sensitization-of-cancer-cells-to-cyclophosphamide-therapy-by-an-organoselenium-compound-through-ros-mediated-apoptosis
#8
Pramita Chakraborty, Somnath Singha Roy, Abhishek Basu, Sudin Bhattacharya
Induction of apoptosis has been recognized as an excellent therapeutic approach in cancer. Selenium based compounds are well known for their antitumor and synergistic chemotherapeutic efficacy when combined with a standard antineoplastic drug. Previously, we have reported that an organoselenium compound, diphenylmethyl selenocyanate (DMSE) could effectively protect normal organs and tissues from the toxicity induced by a standard chemotherapeutic drug cyclophosphamide in a tumor bearing mouse model. In this study, as a further step, we have evaluated the effect of DMSE in sensitization of tumor cells to cyclophosphamide-induced cell death...
November 14, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27814472/phase-iii-randomised-chemoprevention-study-with-selenium-on-the-recurrence-of-non-invasive-urothelial-carcinoma-the-selenium-and-bladder-cancer-trial
#9
Maria E Goossens, Maurice P Zeegers, Hendrik van Poppel, Steven Joniau, Koen Ackaert, Filip Ameye, Ignace Billiet, Johan Braeckman, Alex Breugelmans, Jochen Darras, Kurt Dilen, Lieven Goeman, Bertrand Tombal, Siska Van Bruwaene, Ben Van Cleyenbreugel, Frank Van der Aa, Kris Vekemans, Frank Buntinx
BACKGROUND: In Belgium, bladder cancer (BC) is the fifth most common cancer in men. The per-patient lifetime cost is high. Previous epidemiological studies have consistently reported that selenium concentrations were inversely associated with the risk of BC. We therefore hypothesised that selenium may be suitable for chemoprevention of recurrence of BC. METHOD: The Selenium and Bladder Cancer Trial (SELEBLAT) was an academic phase III placebo-controlled, double-blind, randomised clinical trial designed to determine the effect of selenium on recurrence of non-invasive urothelial carcinoma conducted in 14 Belgian hospitals...
October 28, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27813686/the-telomerase-activity-of-selenium-induced-human-umbilical-cord-mesenchymal-stem-cells-is-associated-with-different-levels-of-c-myc-and-p53-expression
#10
Leila Hosseinzadeh Anvar, Saeid Hosseini-Asl, Mohammad Mohammadzadeh-Vardin, Mohsen Sagha
Selenium-as a trace element-is nutritionally essential for humans. It prevents cancerous growth by inhibiting the telomerase activity but the mechanism involved in regulation of telomerase activity in normal telomerase-positive cells remains to be elucidated. Here, we find out whether the effect of sodium selenite and selenomethionine on telomerase activity in human umbilical cord-derived mesenchymal stem cells (hUCMSCs) is associated with different levels of c-Myc and p53 expression. The use of different staining methods including ethidium bromide/acridine orange and DAPI in addition to telomeric repeat amplification protocol assay and real-time PCR indicated that different forms of selenium have opposite impacts on c-Myc and p53 expressions in both hUCMSCs and AGS, a gastric adenocarcinoma cell line, as a positive control...
November 4, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27797178/in-vitro-and-in-vivo-mechanism-of-bone-tumor-inhibition-by-selenium-doped-bone-mineral-nanoparticles
#11
Yifan Wang, Jianglin Wang, Hang Hao, Mingle Cai, Shiyao Wang, Jun Ma, Yan Li, Chuanbin Mao, Shengmin Zhang
Biocompatible tissue-borne crystalline nanoparticles releasing anticancer therapeutic inorganic elements are intriguing therapeutics holding the promise for both tissue repair and cancer therapy. However, how the therapeutic inorganic elements released from the lattice of such nanoparticles induce tumor inhibition remains unclear. Here we use selenium-doped hydroxyapatite nanoparticles (Se-HANs), which could potentially fill the bone defect generated from bone tumor removal while killing residual tumor cells, as an example to study the mechanism by which selenium released from the lattice of Se-HANs induces apoptosis of bone cancer cells in vitro and inhibits the growth of bone tumors in vivo...
October 31, 2016: ACS Nano
https://www.readbyqxmd.com/read/27782038/the-effect-of-zinc-and-selenium-supplementation-mode-on-their-bioavailability-in-the-rat-prostate-should-administration-be-joint-or-separate
#12
Adam Daragó, Andrzej Sapota, Marzenna Nasiadek, Michał Klimczak, Anna Kilanowicz
It is thought that zinc and selenium deficiency may play a significant role in the etiology of prostate cancer. Although joint zinc and selenium supplementation is frequently applied in the prevention of prostate diseases, the bioavailability of these elements in the prostate after co-administration is still unknown. The study examines the effect of subchronic supplementation of zinc gluconate and selenium compounds (sodium selenite or selenomethionine), administered together or separately, on their bioavailability in the prostate, as well as the induction of metallothionein-like proteins (MTs) bound to zinc in the prostate and liver...
October 4, 2016: Nutrients
https://www.readbyqxmd.com/read/27780927/meta-analysis-of-the-correlation-between-selenium-and-incidence-of-hepatocellular-carcinoma
#13
Ziwei Zhang, Mingyu Bi, Qi Liu, Jie Yang, Shiwen Xu
Hepatocellular carcinoma (HCC) is the most common cancer type. There is a correlation between selenium (Se) deficiency and the incidence of HCC. To clarify the effects of Se level on the risk of HCC patients, a meta-analysis was performed. A total of 9 articles published between 1994 and 2016 worldwide were selected through searching PubMed, EMBASE, web of science, Cochrane Library, Springer Link, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM), and the information were analyzed using a meta-analysis method...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27777421/glutathione-peroxidase-4-a-new-player-in-neurodegeneration
#14
B R Cardoso, D J Hare, A I Bush, B R Roberts
Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was initially described in cancer cells and has since been identified in hippocampal and renal cells. In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration. In addition, we suggest that selenium deficiency enhances susceptibility to ferroptotic processes, as well as other programmed cell death pathways due to a reduction in GPx4 activity...
October 25, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27777235/colorectal-adenomas-in-participants-of-the-select-randomized-trial-of-selenium-and-vitamin-e-for-prostate-cancer-prevention
#15
Peter Lance, David S Alberts, Patricia A Thompson, Liane Fales, Fang Wang, Jerilyn San Jose, Elizabeth T Jacobs, Phyllis J Goodman, Amy K Darke, Monica Yee, Lori Minasian, Ian M Thompson, Denise J Roe
Selenium and vitamin E micronutrients have been advocated for the prevention of colorectal cancer. Colorectal adenoma occurrence was used as a surrogate for colorectal cancer in an ancillary study to the Selenium and Vitamin E Cancer Prevention Trial (SELECT) for prostate cancer prevention. The primary objective was to measure the effect of selenium (as selenomethionine) on colorectal adenomas occurrence, with the effect of vitamin E (as alpha tocopherol) supplementation on colorectal adenoma occurrence considered as a secondary objective...
October 24, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27757244/magnesium-zinc-arsenic-selenium-and-platinum-urinary-excretion-from-cancer-patients-of-antofagasta-region-chile-multi-metal-approach
#16
D A Román, I Pizarro, L Rivera, J Ávila, P Cortés
OBJECTIVES: To evaluate the short-term 24 h urinary excretion of platinum, arsenic, selenium, magnesium and zinc in patients with lung cancer and with cancer other than lungs treated with cisplatin or/and carboplatin from Antofagasta, Chile. DESIGN: Urine measurements of Pt and Se were made by inductively coupled plasma optical emission spectrometry, As by hydride-generation atomic absorption spectrometry and Mg and Zn by means of flame furnace atomic absorption spectrometry...
October 2016: JRSM Open
https://www.readbyqxmd.com/read/27756283/synergistic-complex-from-plants-solanaceae-exhibits-cytotoxicity-for-the-human-hepatocellular-carcinoma-cell-line-hepg2
#17
Romina Schwarzlin, Nika Pušenjak, Damjan Makuc, Mitja Križman, Irena Vovk, Janez Plavec, Urban Švajger
BACKGROUND: It had been demonstrated that sugars from various plants can act as potent agents, which induce apoptosis of cancer cells. METHODS: Using HPLC, we fractionated a mixture of two plant extracts from the plant family Solanaceae, namely Capsicum chinense and the plant family Amaryllidaceae namely Allium sativum. We evaluated the effect of different fractions on apoptosis of HepG2 cell line. The most effective fraction was further studied to determine its molecular composition using mass spectrometry (MS) and NMR...
October 18, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27735956/synthesis-of-28a-homoselenolupanes-and-28a-homoselenolupane-saponins
#18
Katarzyna Sidoryk, Lucie Rárová, Jana Oklešťková, Zbigniew Pakulski, Miroslav Strnad, Piotr Cmoch, Roman Luboradzki
A practical synthesis of 28a-homo-28a-selenolupane triterpenes and the corresponding selenosaponins containing d-mannose, l-arabinose, l-rhamnose, and d-idose moieties is described. Selenium containing triterpenes were obtained from the readily available 3-O-allyl-homobetulin mesylate by nucleophilic substitution with the selenocyanate ion which upon reduction of the -SeCN group afforded the free selenol. Glycosylation using classical Schmidt donors gave 1,2-trans selenosaponins as the main product as well as minute amounts of 1,2-cis isomers...
October 13, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27696310/chemoprotective-and-chemosensitizing-properties-of-selenium-nanoparticle-nano-se-during-adjuvant-therapy-with-cyclophosphamide-in-tumor-bearing-mice
#19
Arin Bhattacharjee, Abhishek Basu, Jaydip Biswas, Tuhinadri Sen, Sudin Bhattacharya
Cyclophosphamide (CP) is one of the widely used anticancer agents; however, it has serious deleterious effects on normal host cells due to its nonspecific action. The essential trace element Selenium (Se) is suggested to have chemopreventive and chemotherapeutic efficacy and currently used in pharmaceutical formulations. Previous report had shown Nano-Se could protect CP-induced hepatotoxicity and genotoxicity in normal Swiss albino mice; however, its role in cancer management is still not clear. The aim of present study is to investigate the chemoprotective efficacy of Nano-Se against CP-induced toxicity as well as its chemoenhancing capability when used along with CP in Swiss albino mice against Ehrlich's ascites carcinoma (EAC) cells...
October 1, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27677458/characterization-and-potential-applications-of-a-selenium-nanoparticle-producing-and-nitrate-reducing-bacterium-bacillus-oryziterrae-sp-nov
#20
Peng Bao, Ke-Qing Xiao, Hui-Jiao Wang, Hao Xu, Peng-Peng Xu, Yan Jia, Max M Häggblom, Yong-Guan Zhu
A novel nitrate- and selenite reducing bacterium strain ZYK(T) was isolated from a rice paddy soil in Dehong, Yunnan, China. Strain ZYK(T) is a facultative anaerobe and grows in up to 150, 000 ppm O2. The comparative genomics analysis of strain ZYK(T) implies that it shares more orthologues with B. subtilis subsp. subtilis NCIB 3610(T) (ANIm values, 85.4-86.7%) than with B. azotoformans NBRC 15712(T) (ANIm values, 84.4-84.7%), although B. azotoformans NBRC 15712(T) (96.3% 16S rRNA gene sequence similarity) is the closest Bacillus species according to 16S rRNA gene comparison...
September 28, 2016: Scientific Reports
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