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Walnuts and cancer

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https://www.readbyqxmd.com/read/28707966/targeted-molecular-ablation-of-cancer-stem-cells-for-curing-gastrointestinal-cancers
#1
Yong Seok Kim, Ho Jae Lee, Jong-Min Park, Young-Min Han, Napapan Kangwan, Ji Young Oh, Dong Yoon Lee, Ki Baik Hahm
Abundance of the ATPase-binding cassette (ABC) transporters and deranged self-renewal pathways characterize the presence of cancer stem cells (CSCs) in gastrointestinal cancers (GI cancers), which play crucial roles in tumorigenesis, chemotherapy resistance, tumor recurrence, and cancer metastasis. Therefore, in order to ensure high cure rates, chemoquiescence, CSCs should be ablated. Recent advances in either understanding CSCs or biomarker identification enable scientists to develop techniques for ablating CSCs and clinicians to provide cancer cure, especially in GI cancers characterized by inflammation-driven carcinogenesis...
July 14, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28555011/the-il-6-gene-promoter-snp-and-plasma-il-6-in-response-to-diet-intervention
#2
Brinda K Rana, Shirley W Flatt, Dennis D Health, Bilge Pakiz, Elizabeth L Quintana, Loki Natarajan, Cheryl L Rock
We recently reported that interleukin-6 (IL-6), an inflammatory marker associated with breast pathology and the development of breast cancer, decreases with diet intervention and weight loss in both insulin-sensitive and insulin-resistant obese women. Here, we tested whether an individual's genotype at an IL6 SNP, rs1800795, which has previously been associated with circulating IL-6 levels, contributes to changes in IL-6 levels or modifies the effect of diet composition on IL-6 in these women. We genotyped rs1800795 in overweight/obese women (N = 242) who were randomly assigned to a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut-rich (18% energy), higher fat (35% energy), lower carbohydrate (45% energy) diet in a 1-year weight loss intervention study of obesity-related biomarkers for breast cancer incidence and mortality...
May 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28463801/anti-cancer-activity-of-myricetin-against-human-papillary-thyroid-cancer-cells-involves-mitochondrial-dysfunction-mediated-apoptosis
#3
Tae Kwun Ha, Inae Jung, Mi Eun Kim, Sung Kwon Bae, Jun Sik Lee
Thyroid cancer is the most common endocrine malignancy and can range in severity from relatively slow-growing occult differentiated thyroid cancer to uniformly aggressive and fatal anaplastic thyroid cancer. A subset of patients with papillary thyroid cancer present with aggressive disease that is refractory to conventional treatment. Myricetin is a flavonol compound found in a variety of berries as well as walnuts and herbs. Previous studies have demonstrated that myricetin exhibits anti-cancer activity against several tumor types...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28373432/myricetin-induces-apoptosis-of-human-anaplastic-thyroid-cancer-cells-via-mitochondria-dysfunction
#4
Sunhyo Jo, Tae Kwun Ha, Sang-Hun Han, Mi Eun Kim, Inae Jung, Hee-Woo Lee, Sung Kwon Bae, Jun Sik Lee
AIM: Thyroid cancer is the most common endocrine malignancy, with an increasing incidence worldwide. Most thyroid cancers are well differentiated and have a favorable outcome. However, undifferentiated thyroid cancers are one of the most lethal human malignancies. Anaplastic thyroid cancer (ATC) accounts for 2% of all thyroid cancers, and its median survival rate is low. ATC is responsible for more than one-third of thyroid cancer-related deaths. Myricetin is a flavonol compound found in walnuts, herbs, and various berries and is known to induce apoptotic death of various types of cancer cells...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/27899257/juglanin-induces-apoptosis-and-autophagy-in-human-breast-cancer-progression-via-ros-jnk-promotion
#5
Zhu-Lei Sun, Jin-Long Dong, Jiang Wu
Breast cancer is one of the most common primary malignant tumors of among women, the long-term survival of which has stagnated in the past decades. Juglanin as a natural production mainly extracted from green walnut husks of Juglans mandshurica has been defined as the functional composition among a series of compounds. It showed powerful protective effect in various diseases by inhibiting inflammation and tumor cells growth. However, the effect of juglanin on human breast cancer and the underlying mechanisms remains to be elucidated...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27733248/effects-of-diet-composition-on-weight-loss-metabolic-factors-and-biomarkers-in-a-1-year-weight-loss-intervention-in-obese-women-examined-by-baseline-insulin-resistance-status
#6
RANDOMIZED CONTROLLED TRIAL
Cheryl L Rock, Shirley W Flatt, Bilge Pakiz, Elizabeth L Quintana, Dennis D Heath, Brinda K Rana, Loki Natarajan
BACKGROUND: Obesity is a risk factor for postmenopausal breast cancer incidence and premenopausal and postmenopausal breast cancer mortality, which may be explained by several metabolic and hormonal factors (sex hormones, insulin resistance, and inflammation) that are biologically related. Differential effects of dietary composition on weight loss and these metabolic factors may occur in insulin-sensitive vs. insulin-resistant obese women. OBJECTIVE: To examine the effect of diet composition on weight loss and metabolic, hormonal and inflammatory factors in overweight/obese women stratified by insulin resistance status in a 1-year weight loss intervention...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27679440/antioxidant-and-anticancer-activities-of-walnut-juglans-regia-l-protein-hydrolysates-using-different-proteases
#7
Raheleh Jahanbani, S Mahmood Ghaffari, Maryam Salami, Kourosh Vahdati, Houri Sepehri, Nazanin Namazi Sarvestani, Nader Sheibani, Ali Akbar Moosavi-Movahedi
Walnut (Juglans regia L.) contains approximately 20-25 % protein with abundant essential amino acids. The enzymatic hydrolysate of Persian walnut (Chandler) seed proteins was prepared by incubation with three different proteases, including pancreatic chymotrypsin and trypsin, and a microbial enzyme proteinase K. The hydrolysates were found to possess excellent antioxidant capacities. The peptide fractions scavenged the 2, 2'-anizo-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) free radicals and inhibited the activity of reactive oxygen species...
December 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27641607/phytochemical-profile-and-biological-activity-of-juglans-regia
#8
REVIEW
Nisha Panth, Keshav Raj Paudel, Rajendra Karki
Juglans regia Linn. (Juglandaceae), popularly known as English or Persian walnut, is a valuable medicinal plant with a potency to cure various diseases in traditional medicine. Since ancient time, different local ethnic groups have used various part of J. regia for a wide array of ailments including helminthiasis, diarrhea, sinusitis, stomach ache, arthritis, asthma, eczema, scrofula, skin disorders, diabetes mellitus, anorexia, thyroid dysfunction, cancer and infectious diseases. Biological activities of J...
September 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27633111/improvements-in-metabolic-health-with-consumption-of-ellagic-acid-and-subsequent-conversion-into-urolithins-evidence-and-mechanisms
#9
REVIEW
Inhae Kang, Teresa Buckner, Neil F Shay, Liwei Gu, Soonkyu Chung
Ellagic acid (EA) is a naturally occurring polyphenol found in some fruits and nuts, including berries, pomegranates, grapes, and walnuts. EA has been investigated extensively because of its antiproliferative action in some cancers, along with its anti-inflammatory effects. A growing body of evidence suggests that the intake of EA is effective in attenuating obesity and ameliorating obesity-mediated metabolic complications, such as insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and atherosclerosis...
September 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/27455311/walnut-phenolic-extract-and-its-bioactive-compounds-suppress-colon-cancer-cell-growth-by-regulating-colon-cancer-stemness
#10
COMPARATIVE STUDY
Jisoo Lee, Yoo-Sun Kim, JaeHwan Lee, Seung Chul Heo, Kook Lae Lee, Sang-Woon Choi, Yuri Kim
Walnut has been known for its health benefits, including anti-cardiovascular disease and anti-oxidative properties. However, there is limited evidence elucidating its effects on cancer stem cells (CSCs) which represent a small subset of cancer cells that provide resistance against chemotherapy. This study aimed to evaluate the anti-CSCs potential of walnut phenolic extract (WPE) and its bioactive compounds, including (+)-catechin, chlorogenic acid, ellagic acid, and gallic acid. In the present study, CD133⁺CD44⁺ cells were isolated from HCT116 cells using fluorescence-activated cell sorting (FACS) and then treated with WPE...
July 21, 2016: Nutrients
https://www.readbyqxmd.com/read/27261574/curcumin-and-ellagic-acid-synergistically-induce-ros-generation-dna-damage-p53-accumulation-and-apoptosis-in-hela-cervical-carcinoma-cells
#11
Devbrat Kumar, Soumya Basu, Lucy Parija, Deeptimayee Rout, Sanjeet Manna, Jagneshwar Dandapat, Priya Ranjan Debata
Cervical cancer and precancerous lesions of the cervix continue to be a global health issue, and the medication for the treatment for chronic HPV infection so far has not been effective. Potential anticancer and anti HPV activities of two known phytochemicals, Curcumin and Ellagic acid were evaluated in HeLa cervical cancer cells. Curcumin is a natural compound found in the root of Curcuma longa plant and Ellagic acid a polyphenol found in fruits of strawberries, raspberries and walnuts. The combination of Curcumin and Ellagic acid at various concentrations showed better anticancer properties than either of the drug when used alone as evidenced by MTT assay...
July 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27215566/effects-of-walnut-consumption-on-colon-carcinogenesis-and-microbial-community-structure
#12
Masako Nakanishi, Yanfei Chen, Veneta Qendro, Shingo Miyamoto, Erica Weinstock, George M Weinstock, Daniel W Rosenberg
Walnuts are composed of a complex array of biologically active constituents with individual cancer-protective properties. Here, we assessed the potential benefit of whole walnut consumption in a mouse tumor bioassay using azoxymethane. In study 1, a modest reduction (1.3-fold) in tumor numbers was observed in mice fed a standard diet (AIN-76A) containing 9.4% walnuts (15% of total fat). In study 2, the effects of walnut supplementation was tested in the Total Western Diet (TWD). There was a significant reduction (2...
August 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27143875/novel-walnut-peptide-selenium-hybrids-with-enhanced-anticancer-synergism-facile-synthesis-and-mechanistic-investigation-of-anticancer-activity
#13
Wenzhen Liao, Rong Zhang, Chenbo Dong, Zhiqiang Yu, Jiaoyan Ren
This contribution reports a facile synthesis of degreased walnut peptides (WP1)-functionalized selenium nanoparticles (SeNPs) hybrids with enhanced anticancer activity and a detailed mechanistic evaluation of its superior anticancer activity. Structural and chemical characterizations proved that SeNPs are effectively capped with WP1 via physical absorption, resulting in a stable hybrid structure with an average diameter of 89.22 nm. A panel of selected human cancer cell lines demonstrated high susceptibility toward WP1-SeNPs and displayed significantly reduced proliferative behavior...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/26995228/in%C3%A2-vivo-relevant-mixed-urolithins-and-ellagic-acid-inhibit-phenotypic-and-molecular-colon-cancer-stem-cell-features-a-new-potentiality-for-ellagitannin-metabolites-against-cancer
#14
María Ángeles Núñez-Sánchez, Ankur Karmokar, Antonio González-Sarrías, Rocío García-Villalba, Francisco A Tomás-Barberán, María Teresa García-Conesa, Karen Brown, Juan Carlos Espín
Colon cancer stem cells (CSCs) offer a novel paradigm for colorectal cancer (CRC) treatment and dietary polyphenols may contribute to battle these cells. Specifically, polyphenol-derived colon metabolites have the potential to interact with and affect colon CSCs. We herein report the effects against colon CSCs of two mixtures of ellagitannin (ET) metabolites, ellagic acid (EA) and the gut microbiota-derived urolithins (Uro) at concentrations detected in the human colon tissues following the intake of ET-containing products (pomegranate, walnuts)...
June 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/26863018/a-modified-olanzapine-regimen-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting
#15
Hormozan Sorooshian, Long Vo
BACKGROUND: At Kaiser Permanente Antioch and Walnut Creek Cancer Centers, a modified olanzapine regimen is used to prevent chemotherapy-induced nausea and vomiting (CINV) in patients who receive highly emetogenic chemotherapy (HEC). OBJECTIVE: To determine if an olanzapine, ondansetron, dexamethasone (OOD) regimen is noninferior to a fosaprepitant, ondansetron, dexamethasone (FOD) regimen in preventing CINV in patients receiving HEC. METHODS: This retrospective cohort study compared the rates of CINV in patients who were treated with HEC and received either the OOD or FOD regimen...
November 2015: Journal of Community and Supportive Oncology
https://www.readbyqxmd.com/read/26713565/health-benefits-of-walnut-polyphenols-an-exploration-beyond-their-lipid-profile
#16
Claudia Sánchez-González, Carlos Ciudad, Véronique Noé, Maria Izquierdo-Pulido
Walnuts are commonly found in our diet and have been recognized for their nutritious properties for a long time. Traditionally, walnuts have been known for their lipid profile which has been linked to a wide array of biological properties and health-promoting effects. In addition to essential fatty acids, walnuts contain a variety of other bioactive compounds such as, vitamin E and polyphenols. Among common foods and beverages, walnuts represent one of the most important sources of polyphenols, hence, their effect over human health warrants attention...
December 29, 2015: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/26609527/coevolution-between-cancer-activities-and-food-structure-of-human-being-from-southwest-china
#17
REVIEW
Yawen Zeng, Juan Du, Xiaoying Pu, Jiazhen Yang, Tao Yang, Shuming Yang, Xiaomeng Yang
Yunnan and Tibet are the lowest cancer mortality and the largest producer for anticancer crops (brown rice, barley, buckwheat, tea, walnut, mushrooms, and so forth). Shanghai and Jiangsu province in China have the highest mortality of cancers, which are associated with the sharp decline of barley.
2015: BioMed Research International
https://www.readbyqxmd.com/read/26593407/isolation-of-a-novel-bio-peptide-from-walnut-residual-protein-inducing-apoptosis-and-autophagy-on-cancer-cells
#18
Sihui Ma, Di Huang, Mengxin Zhai, Lubing Yang, Sen Peng, Changxu Chen, Xiaoru Feng, Qiang Weng, Bolin Zhang, Meiyu Xu
BACKGROUND: Walnut is unique because they have a perfect balance of n-6 and n-3 polyunsaturated fatty acids. The increasing market demand of walnut lipids results in the large amount of the oil extraction residue. The walnut residue is rich in nutritional proteins, and the uneconomic use of the by-product discouraged the development of walnut industry. Anticancer peptides have recently received attention as alternative chemotherapeutic agents that overcome the limits of current drugs...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26506336/cytotoxicity-of-triterpenes-from-green-walnut-husks-of-juglans-mandshurica-maxim-in-hepg-2-cancer-cells
#19
Yuanyuan Zhou, Bingyou Yang, Zhaoxi Liu, Yanqiu Jiang, Yuxin Liu, Lei Fu, Xiaoli Wang, Haixue Kuang
Among the classes of identified natural products, triterpenoids, one of the largest families, have been studied extensively for their diverse structures and variety of biological activities, including antitumor effects. In the present study, a phytochemical study of the green walnut husks of Juglans mandshurica Maxim led to the isolation of a new dammarane triterpene, 12β, 20(R), 24(R)-trihydroxydammar-25-en-3-one (6), together with sixteen known compounds, chiefly from chloroform and ethyl acetate extracts...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26412432/identfication-of-new-naphthalenones-from-juglans-mandshurica-and-evalution-of-their-anticancer-activities
#20
Li-Na Guo, Rui Zhang, Xue-Ying Guo, Tao Cui, Wei Dong, Jin-Hai Huo, Wei-Ming Wang
Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1) and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 (g(mL(-1).
September 2015: Chinese Journal of Natural Medicines
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