keyword
MENU ▼
Read by QxMD icon Read
search

Ketogenesis

keyword
https://www.readbyqxmd.com/read/29750205/more-than-a-powerplant-the-influence-of-mitochondrial-transfer-on-the-epigenome
#1
Alexander N Patananan, Alexander J Sercel, Michael A Teitell
Each cell in the human body, with the exception of red blood cells, contains multiple copies of mitochondria that house their own genetic material, the maternally inherited mitochondrial DNA. Mitochondria are the cell's powerplant due to their massive ATP generation. However, the mitochondrion is also a hub for metabolite production from the TCA cycle, fatty acid beta-oxidation, and ketogenesis. In addition to producing macromolecules for biosynthetic reactions and cell replication, several mitochondrial intermediate metabolites serve as cofactors or substrates for epigenome modifying enzymes that regulate chromatin structure and impact gene expression...
June 2018: Current Opinion in Physiology
https://www.readbyqxmd.com/read/29746259/epigenetic-fleas-bite-the-genome-in-bone-health-muscle-strength-the-gut-heart-health-and-during-ketogenesis
#2
George Grimble
No abstract text is available yet for this article.
May 8, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29738703/high-fat-diet-induced-obesity-is-mitigated-in-cyp3a-null-female-mice
#3
Ramiya Kumar, Elizabeth J Litoff, W Tyler Boswell, William S Baldwin
Recent studies indicate a role for the constitutive androstane receptor (CAR), pregnane X-receptor (PXR), and hepatic xenobiotic detoxifying CYPs in fatty liver disease or obesity. Therefore, we examined whether Cyp3a-null mice show increased obesity and fatty liver disease following 8-weeks of exposure to a 60% high-fat diet (HFD). Surprisingly, HFD-fed Cyp3a-null females fed a HFD gained 50% less weight than wild-type (WT; B6) females fed a HFD. In contrast, Cyp3a-null males gained more weight than WT males, primarily during the first few weeks of HFD-treatment...
May 5, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29738435/crebh-regulates-systemic-glucose-and-lipid-metabolism
#4
REVIEW
Yoshimi Nakagawa, Hitoshi Shimano
The cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor that primarily localizes in the liver and small intestine. CREBH governs triglyceride metabolism in the liver, which mediates the changes in gene expression governing fatty acid oxidation, ketogenesis, and apolipoproteins related to lipoprotein lipase (LPL) activation. CREBH in the small intestine reduces cholesterol transporter gene Npc1l1 and suppresses cholesterol absorption from diet...
May 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29723773/different-ketogenesis-strategies-lead-to-disparate-seizure-outcomes
#5
Alison Dolce, Polan Santos, Weiran Chen, Ahmet Hoke, Adam L Hartman
BACKGROUND: Despite the introduction of new medicines to treat epilepsy over the last 50 years, the number of patients with poorly-controlled seizures remains unchanged. Metabolism-based therapies are an underutilized treatment option for this population. We hypothesized that two different means of systemic ketosis, the ketogenic diet and intermittent fasting, would differ in their acute seizure test profiles and mitochondrial respiration. METHODS: Male NIH Swiss mice (aged 3-4 weeks) were fed for 12-13 days using one of four diet regimens: ketogenic diet (KD), control diet matched to KD for protein content and micronutrients (CD), or CD with intermittent fasting (24 h feed/24 h fast) (CD-IF), tested post-feed or post-fast...
April 27, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29715177/updated-review-of-postmortem-biochemical-exploration-of-hypothermia-with-a-presentation-of-standard-strategy-of-sampling-and-analyses
#6
Guillaume Rousseau, Pascal Reynier, Nathalie Jousset, Clotilde Rougé-Maillart, Cristian Palmiere
Hypothermia is defined as a core body temperature below 35°C and can be caused by environmental exposure, drug intoxication, metabolic or nervous system dysfunction. This lethal pathology with medico-legal implications is complex to diagnose because macroscopic and microscopic lesions observed at the autopsy and the histological analysis are suggestive but not pathognomonic. Postmortem biochemical explorations have been progressively developed through the study of several biomarkers to improve the diagnosis decision cluster...
May 1, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29712492/a-critical-review-on-the-concept-of-avapeedaka-snehapana-a-special-mode-of-lipid-administration
#7
P B Kadambari, Prasanth Dharmarajan, C K Prathibha, P V Anandaraman
Avapeedaka Snehapana is a unique and special method of internal administration of Sneha dravya (unctuous medicine) mentioned in the classical ayurveda texts. It is mainly indicated in mutravegarodha janya vikara (diseases due to the suppression of urge of micturition). Because of the lack of adequate review and analysis, this method of administration of snehapana (internal administration of lipid) is losing its significance from the practices and the concept remains unexplored. The reasons for not being practiced like other snehana (oleation therapy) procedures are because of the less understanding of the concept of administration, scattered and minimal textual references...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29710380/effects-of-postoperative-parenteral-nutrition-enhanced-by-multivitamin-on-metabolic-phenotype-in-postoperative-gastric-cancer-patients
#8
Zi-Jian Li, Wei Chen, Hua Jiang, Xiao-Yi Li, Sai-Nan Zhu, Xiao-Liu Liu
SCOPE: To investigated the effects of postoperative parenteral nutrition (PN) with multivitamins supplementation on oxidative stress and metabolism. METHODS AND RESULTS: The participants were randomly assigned in a 1:1 ratio to groups: total nutrient admixture (TNA)+ multivitamin (n = 14, Group A) and TNA+ normal saline (n = 16, Group B). The levels of blood vitamins, ILs and MDA were assessed and the dysregulation of metabolism was analyzed using nontargeted metabolite profiling...
April 30, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29705001/dendritic-peptide-bolaamphiphiles-for-sirna-delivery-to-primary-adipocytes
#9
Alexander C Eldredge, Mark E Johnson, Yang Cao, Lin Zhang, Can Zhao, Zhengxia Liu, Qin Yang, Zhibin Guan
Obesity is a major risk factor for diabetes, heart disease and other health problems. Adipose tissue plays a central role in the development of obesity and obesity-associated diseases. Gene therapy targeting adipose tissue may provide a promising strategy for obesity treatment. However, nucleic acid delivery to adipose tissue or even cultured adipocytes is challenging due to low delivery efficacy and high toxicity of the current cationic lipid based delivery systems, or monoamphiphiles. Herein, we report using dendritic peptide bolaamphiphiles (bolas) to deliver siRNA to primary adipocytes and hepatocytes...
April 16, 2018: Biomaterials
https://www.readbyqxmd.com/read/29702025/depp-depp1-c10orf10-regulates-hepatic-glucose-and-fat-metabolism-partly-via-ros-induced-fgf21
#10
Wenli Li, Meiling Ji, Yandie Lin, Yi Miao, Simin Chen, Hao Li
Decidual protein induced by progesterone (DEPP/DEPP1/C10ORF10) is induced by denying access to food and reduced by refeeding in insulin-sensitive organs in vivo. The negative regulation of DEPP by insulin is also proven in several cell lines. However, the functions of DEPP in insulin-sensitive organs remain unknown. In the present study, we investigated the impact of DEPP on hepatic energy metabolism and addressed the underlying mechanisms. The metabolic effects of DEPP were investigated in mice with adenovirus-mediated hepatic overexpression...
April 27, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29663292/the-potential-role-of-sglt2-inhibitors-in-the-treatment-of-type-1-diabetes-mellitus
#11
Hadi Fattah, Volker Vallon
Type 1 diabetes mellitus is a difficult disease to treat due to the relative paucity of therapeutic options other than injectable insulin. The latter, however, can induce hypoglycemia, which has been linked to enhanced cardiovascular risk. Sodium glucose cotransporter 2 (SGLT2) inhibitors are a new class of oral anti-hyperglycemic medications that do not increase the hypoglycemia risk and are US Food and Drug Administration (FDA) approved in type 2 diabetes mellitus. SGLT2 inhibitors may also be of benefit in type 1 diabetic patients, in addition to insulin, although they have not yet been approved for this indication...
April 16, 2018: Drugs
https://www.readbyqxmd.com/read/29649104/coordination-of-gpr40-and-ketogenesis-signaling-by-medium-chain-fatty-acids-regulates-beta-cell-function
#12
Julien Benjamin Pujol, Nicolas Christinat, Yann Ratinaud, Claudia Savoia, Siobhan E Mitchell, El Hadji M Dioum
Diabetes prevalence increases with age, and β-cell dysfunction contributes to the incidence of the disease. Dietary lipids have been recognized as contributory factors in the development and progression of the disease. Unlike long chain triglycerides, medium chain triglycerides (MCT) increase fat burning in animal and human subjects as well as serum C-peptide in type 2 diabetes patients. We evaluated the beneficial effects of MCT on β-cells in vivo and in vitro. MCT improved glycemia in aged rats via β-cell function assessed by measuring insulin secretion and content...
April 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29624009/the-concentration-of-free-amino-acids-in-blood-serum-of-dairy-cows-with-primary-ketosis
#13
J Marczuk, P Brodzki, A Brodzki, Ł Kurek
Ketosis is a common condition found in the initial stages of lactation in high-yielding dairy cows. The major cause of ketosis is a negative energy balance. During the energy deficiency, proteolysis processes develop parallel to lipolysis. During proteolysis, muscle tissue can be used as a source of amino acid. To date, the participation of amino acids in gluconeogenesis (glucogenic amino acids) and ketogenesis (ketogenic amino acids) has not been determined in detail. This paper presents the study on determination of the parameters of protein and free amino acid metabolism in blood serum of dairy cows with primary ketosis compared to healthy cows...
March 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29601848/food-safety-using-nmr-based-metabolomics-assessment-of-the-atlantic-bluefin-tuna-thunnus-thynnus-from-the-mediterranean-sea
#14
Tiziana Cappello, Alessia Giannetto, Vincenzo Parrino, Giuseppe De Marco, Angela Mauceri, Maria Maisano
Seafood is a valuable component of human diet because of its nutritional properties. The Atlantic bluefin tuna Thunnus thynnus is a scombroid fish highly appreciated as seafood worldwide. Being a top pelagic predator, concerns have been raised over human health risks due to its consumption. Therefore, herein it was comprehensively evaluated the health status and potential metabolite shifts between sexes of bluefin tuna from the Mediterranean Sea, proved to bioaccumulate environmental obesogens, namely polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) at hepatic level...
March 27, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29596655/enhanced-hepatic-ppar%C3%AE-activity-links-glut8-deficiency-to-augmented-peripheral-fasting-responses-in-male-mice
#15
Allyson L Mayer, Yiming Zhang, Emily H Feng, Cassandra B Higgins, Oyin Adenekan, Terri A Pietka, Wandy L Beatty, Brian J DeBosch
The adaptive fasting response is invoked as a promising cardiometabolic and neurodegenerative therapeutic pathway. We and others have defined the carbohydrate transporter, GLUT8, as a critical regulator of hepatic and whole-organism metabolic homeostasis in the overfed and diabetic states. However, the functions of this critical transporter in the physiological fasting response remain poorly understood. Here, we tested the hypothesis that GLUT8 modulates the adaptive hepatic fasting response. We demonstrate that mice with targeted Slc2a8 disruption exhibit enhanced thermogenesis, ketogenesis and peripheral lipid mobilization during fasting...
March 26, 2018: Endocrinology
https://www.readbyqxmd.com/read/29576959/the-use-of-nutritional-supplements-to-induce-ketosis-and-reduce-symptoms-associated-with-keto-induction-a-narrative-review
#16
Cliff J D C Harvey, Grant M Schofield, Micalla Williden
Background: Adaptation to a ketogenic diet (keto-induction) can cause unpleasant symptoms, and this can reduce tolerability of the diet. Several methods have been suggested as useful for encouraging entry into nutritional ketosis (NK) and reducing symptoms of keto-induction. This paper reviews the scientific literature on the effects of these methods on time-to-NK and on symptoms during the keto-induction phase. Methods: PubMed, Science Direct, CINAHL, MEDLINE, Alt Health Watch, Food Science Source and EBSCO Psychology and Behavioural Sciences Collection electronic databases were searched online...
2018: PeerJ
https://www.readbyqxmd.com/read/29575149/exercise-decreases-clk2-in-the-liver-of-obese-mice-and-prevents-hepatic-fat-accumulation
#17
Vitor R Muñoz, Rafael C Gaspar, Gabriel K Kuga, Susana C B R Nakandakari, Igor L Baptista, Rania A Mekary, Adelino S R da Silva, Leandro P de Moura, Eduardo R Ropelle, Dennys E Cintra, José R Pauli
The accumulation of fatty acids in the liver associated with obesity condition is also known as nonalcoholic fatty liver disease (NAFLD). The impaired fat oxidation in obesity condition leads to increased hepatic fat accumulation and increased metabolic syndrome risk. On the other hand, physical exercise has been demonstrated as a potent strategy in the prevention of NAFLD. Also, these beneficial effects of exercise occur through different mechanisms. Recently, the Cdc2-like kinase (CLK2) protein was associated with the suppression of fatty acid oxidation and hepatic ketogenesis...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29523524/genome-wide-association-study-identifies-the-hmgcs2-locus-to-be-associated-with-chlorthalidone-induced-glucose-increase-in-hypertensive-patients
#18
Sonal Singh, Caitrin W McDonough, Yan Gong, Wael A Alghamdi, Meghan J Arwood, Salma A Bargal, Leanne Dumeny, Wen-Yi Li, Mai Mehanna, Bradley Stockard, Guang Yang, Felipe A de Oliveira, Natalie C Fredette, Mohamed H Shahin, Kent R Bailey, Amber L Beitelshees, Eric Boerwinkle, Arlene B Chapman, John G Gums, Stephen T Turner, Rhonda M Cooper-DeHoff, Julie A Johnson
BACKGROUND: Thiazide and thiazide-like diuretics are first-line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with incompletely understood mechanisms. Our goal was to identify genomic variants associated with thiazide-like diuretic/chlorthalidone-induced glucose change. METHODS AND RESULTS: Genome-wide analysis of glucose change after treatment with chlorthalidone was performed by race among the white (n=175) and black (n=135) participants from the PEAR-2 (Pharmacogenomic Evaluation of Antihypertensive Responses-2)...
March 9, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29506485/transcriptional-profiling-of-liver-in-riboflavin-deficient-chicken-embryos-explains-impaired-lipid-utilization-energy-depletion-massive-hemorrhaging-and-delayed-feathering
#19
Larry A Cogburn, Danielle N Smarsh, Xiaofei Wang, Nares Trakooljul, Wilfrid Carré, Harold B White
BACKGROUND: A strain of Leghorn chickens (rd/rd), unable to produce a functional riboflavin-binding protein, lays riboflavin-deficient eggs, in which all embryos suddenly die at mid-incubation (days 13-15). This malady, caused by riboflavin deficiency, leads to excessive lipid accumulation in liver, impaired β-oxidation of lipid, and severe hypoglycemia prior to death. We have used high-density chicken microarrays for time-course transcriptional scans of liver in chicken embryos between days 9-15 during this riboflavin-deficiency-induced metabolic catastrophe...
March 5, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29483892/efficacy-of-modified-atkins-ketogenic-diet-in-chronic-cluster-headache-an-open-label-single-arm-clinical-trial
#20
Cherubino Di Lorenzo, Gianluca Coppola, Davide Di Lenola, Maurizio Evangelista, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Mariano Serrao, Francesco Pierelli
Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine. Aim: Here, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients. Materials and methods: Eighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50% attack reduction)...
2018: Frontiers in Neurology
keyword
keyword
11253
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"