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Cinnamon and cancer

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https://www.readbyqxmd.com/read/28813148/chitosan-coated-cinnamon-oregano-loaded-solid-lipid-nanoparticles-to-augment-5-fluorouracil-cytotoxicity-for-colorectal-cancer-extracts-standardization-nanoparticles-optimization-and-cytotoxicity-evaluation
#1
Kamel M Kamel, Islam A Khalil, Mostafa E Rateb, Hosieny Elgendy, Seham Elhawary
This study aimed to coat lipid-based-nanocarriers with chitosan to encapsulate nutraceuticals, minimize opsonization and facilitate passive-targeting. Phase-one was concerned with standardization according to WHO. Qualitative-analysis using LC-HRMS/MS investigated the active-constituents especially reported cytotoxic-agents. Cinnamaldehyde and rosmarinic acid was selected to be quantified using HPLC. Phase-two was aimed to encapsulate both extracts in solid lipid nanoparticles (core) and chitosan (shell) to gain the advantages of both materials properties...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28688915/targeted-proteome-analysis-with-isotope-coded-protein-labels-for-monitoring-the-influence-of-dietary-phytochemicals-on-the-expression-of-cytoprotective-proteins-in-primary-human-colon-cells
#2
Christiane Östreicher, Sven Bartenbacher, Monika Pischetsrieder
Cytoprotective effects by upregulating cellular expression levels of antioxidant proteins are attributed to a significant number of food ingredients. Evaluation of those cytoprotective effects and identification of the most active components requires reliable and comprehensive proteomic strategies. Thus, promising potential bioactive ingredients could be determined for the prevention of various diseases, including colon cancer formation. We established a multiplexed nanoLC-MS/MS targeted proteomic method, operated in scheduled selected reaction monitoring mode (sSRM), to record modulation of the expression levels of six major antioxidant proteins induced by dietary phytochemicals...
July 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28609656/kupffer-cell-derived-tnf-triggers-cholangiocellular-tumorigenesis-through-jnk-due-to-chronic-mitochondrial-dysfunction-and-ros
#3
Detian Yuan, Shan Huang, Emanuel Berger, Lei Liu, Nina Gross, Florian Heinzmann, Marc Ringelhan, Tracy O Connor, Mira Stadler, Michael Meister, Julia Weber, Rupert Öllinger, Nicole Simonavicius, Florian Reisinger, Daniel Hartmann, Rüdiger Meyer, Maria Reich, Marco Seehawer, Valentina Leone, Bastian Höchst, Dirk Wohlleber, Simone Jörs, Marco Prinz, Duncan Spalding, Ulrike Protzer, Tom Luedde, Luigi Terracciano, Matthias Matter, Thomas Longerich, Percy Knolle, Thomas Ried, Verena Keitel, Fabian Geisler, Kristian Unger, Einat Cinnamon, Eli Pikarsky, Norbert Hüser, Roger J Davis, Darjus F Tschaharganeh, Roland Rad, Achim Weber, Lars Zender, Dirk Haller, Mathias Heikenwalder
Intrahepatic cholangiocarcinoma (ICC) is a highly malignant, heterogeneous cancer with poor treatment options. We found that mitochondrial dysfunction and oxidative stress trigger a niche favoring cholangiocellular overgrowth and tumorigenesis. Liver damage, reactive oxygen species (ROS) and paracrine tumor necrosis factor (Tnf) from Kupffer cells caused JNK-mediated cholangiocellular proliferation and oncogenic transformation. Anti-oxidant treatment, Kupffer cell depletion, Tnfr1 deletion, or JNK inhibition reduced cholangiocellular pre-neoplastic lesions...
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28444928/antiinflammatory-activity-of-cinnamon-cinnamomum-zeylanicum-bark-essential-oil-in-a-human-skin-disease-model
#4
Xuesheng Han, Tory L Parker
The effect of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) on human skin cells has not been elucidated. Therefore, we investigated the activity of a commercially available CBEO in a validated human dermal fibroblast system, a model of chronic inflammation and fibrosis. We first evaluated the impact of CBEO on 17 protein biomarkers that play critical roles in inflammation and tissue remodeling. The impact of CBEO on genome-wide gene expression was also evaluated. CBEO showed strong anti-proliferative effects on skin cells and significantly inhibited the production of several inflammatory biomarkers, including vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interferon gamma-induced protein 10, interferon-inducible T-cell alpha chemoattractant, and monokine induced by gamma interferon...
July 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28358602/in-vitro-incorporation-of-radioiodinated-eugenol-on-adenocarcinoma-cell-lines-caco2-mcf7-and-pc3
#5
Emine Dervis, Ayfer Yurt Kilcar, Emin Ilker Medine, Volkan Tekin, Buse Cetkin, Emre Uygur, Fazilet Zumrut Biber Muftuler
Recently, the synthesis of radiolabeled plant origin compounds has been increased due to their high uptake on some cancer cell lines. Eugenol (EUG), a phenolic natural compound in the essential oils of different spices such as Syzygium aromaticum (clove), Pimenta racemosa (bay leaves), and Cinnamomum verum (cinnamon leaf), has been exploited for various medicinal applications. EUG has antiviral, antioxidant, and anti-inflammatory functions and several anticancer properties. The objective of this article is to synthesize radioiodinated ((131)I) EUG and investigate its effect on Caco2, MCF7, and PC3 adenocarcinoma cell lines...
April 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28071013/the-industrial-potential-of-herbs-and-spices-a-mini-review
#6
REVIEW
Katarzyna B Leja, Katarzyna Czaczyk
Herbs and spices have been used for food and medicinal purposes for centuries - the first recorded evidence of their use dates back to 1500BC and the Ebers Papyrus, which mentioned spices such as anise, mustard, saffron, cinnamon, and cassia. Now, in the 21st century, a variety of secondary compounds produced by plants are used in many fields of industry, such as food production (to improve taste, to provide vitamins and macro- and microelements, and also to inhibit food spoilage caused by foodborne bacteria), in medicine (in the treatment of various diseases; in chemoprevention and cancer therapy; as a source of natural antimicrobials for the treatment of infectious disease), and in pharmacology and cosmetology (in dietary supplements, and as a result of the demand for preservative-free cosmetics, to reduce the risk of methylparaben allergies)...
October 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/27771918/cinnamon-and-chronic-diseases
#7
REVIEW
Mitra Hariri, Reza Ghiasvand
Cinnamon (Cinnamomum zeylanicum and Cinnamon cassia), the eternal tree of tropical medicine, belongs to the Lauraceae family and is one of the most important spices used daily by people all over the world. It contains a lot of manganese, iron, dietary fiber, and calcium. Cinnamon contains derivatives, such as cinnamaldehyde, cinnamic acid, cinnamate, and numerous other components such as polyphenols and antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer effects. Several reports have dealt with the numerous properties of cinnamon in the forms of bark, essential oils, bark powder, and phenolic compounds, and each of these properties can play a key role in human health...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27465514/the-aqueous-extract-of-cinnamon-bark-ameliorated-cisplatin-induced-cytotoxicity-in-vero-cells-without-compromising-the-anticancer-efficiency-of-cisplatin
#8
Ayman I ElKady, Wafaa S Ramadan
AIM: Cis-diammine dichloroplatinum (CDDP) is one of the most important chemotherapeutic agents for cancer treatment. Nonetheless, its notable side effect, nephrotoxicity, undermines its clinical use. The current study was undertaken to evaluate the protective potential of the aqueous extract (AEC) of Cinnamomum cassia (cinnamon) against the cytotoxic effect of CDDP in vitro and to elaborate the molecular mechanism underlying protection. METHODS: MTT assay was performed to assess viability of the normal kidney Vero cells treated with CDDP and/or AEC...
September 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27253180/cinnamon-extract-reduces-vegf-expression-via-suppressing-hif-1%C3%AE-gene-expression-and-inhibits-tumor-growth-in-mice
#9
Keqiang Zhang, Ernest S Han, Thanh H Dellinger, Jianming Lu, Sangkil Nam, Richard A Anderson, John H Yim, Wei Wen
Although many anti-VEGF agents are available for cancer treatment, side effects of these agents limit their application for cancer treatment and prevention. Here we studied the potential use of a diet-based agent as an inhibitor for VEGF production. Using a VEGF reporter assay, our data showed that an extract from cinnamon (CE) was a potent inhibitor of VEGF production in human cancer cells and suggested inhibition might be mediated through the suppression of HIF-1α gene expression and protein synthesis. Furthermore, CE treatment was found to inhibit expression and phosphorylation of STAT3 and AKT, which are key factors in the regulation of HIF-1α expression, and significantly reduce angiogenesis potential of cancer cells by migration assay...
February 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27245453/medicinal-attributes-of-major-phenylpropanoids-present-in-cinnamon
#10
Uma Kant Sharma, Amit Kumar Sharma, Abhay K Pandey
BACKGROUND: Excessive production of free radicals has been implicated in many diseases including cancer. They are highly reactive and bring about oxidation of biomolecules i.e., proteins, lipids and nucleic acids which are associated with many degenerative diseases. Natural products acting as antioxidants have ability to neutralize free radicals and their actions and hence they mitigate their harmful effects. The present study was designed to investigate pharmacological properties viz...
May 31, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27113744/discovery-of-a-novel-anti-cancer-agent-targeting-both-topoisomerase-i-ii-as-well-as-telomerase-activities-in-human-lung-adenocarcinoma-a549-cells-in-vitro-and-in-vivo-cinnamomum-verum-component-cuminaldehyde
#11
Ta-Wei Chen, Kuen-Daw Tsai, Shu-Mei Yang, Ho-Yiu Wong, Yi-Heng Liu, Jonathan Cherng, Kuo-Shen Chou, Yang-Tz Wang, Janise Cuizon, Jaw-Ming Cherng
Cinnamomum verum is used to make the spice cinnamon and has been used for more than 5000 years by both of the two most ancient forms of medicine in the words: Ayurveda and traditional Chinese herbal medicines for various applications such as adenopathy, rheumatism, dermatosis, dyspepsia, stroke, tumors, elephantiasis, trichomonas, yeast, and virus infections. We evaluated the anticancer effect of cuminaldehyde (CuA), a constituent of the bark of the plant, and its underlying molecular biomarkers associated with carcinogenesis in human lung adenocarcinoma A549 cells...
2016: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/27092039/anti-oncogenic-perspectives-of-spices-herbs-a-comprehensive-review
#12
REVIEW
Masood Sadiq Butt, Ambreen Naz, Muhammad Tauseef Sultan, Mir Muhammad Nasir Qayyum
Contemporary nutrition regime has focused the attention of the researchers on phytochemicals enriched spices to mitigate various oncological threats. Numerous chemopreventive strategies against malignancy have been developed considering the anticancer perspectives of allied nutraceutical constituents. Current evidences have proven an inverse association of spices with that of oncological incidences. The high antioxidant activity of spices derived bioactives triggers the free radicals scavenging ability at cellular level thereby alleviating various metabolic syndromes...
2013: EXCLI journal
https://www.readbyqxmd.com/read/26854449/essential-oil-of-cinnamon-exerts-anti-cancer-activity-against-head-and-neck-squamous-cell-carcinoma-via-attenuating-epidermal-growth-factor-receptor-tyrosine-kinase
#13
Xin-Qing Yang, Hao Zheng, Qing Ye, Rui-Yu Li, Yong Chen
PURPOSE: Impressed by the exceptional anticancer activity of cinnamon, the present study was conducted to elucidate the anticancer potential of essential oil of Cinnamon (EOC). METHODS: EOC was tested against various cell lines (FaDu, Detroit-562 and SCC-25) of head and neck squamous cell carcinoma (HNSCC) using MTT assay. The Hep-2 cell xenograft model was used to assess the positive bio-activity of EOC. EGFR-TK inhibitory assay was also carried out to explain the possible mechanism of action of EOC...
November 2015: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/26810587/toward-clinical-genomics-in-everyday-medicine-perspectives-and-recommendations
#14
Susan K Delaney, Michael L Hultner, Howard J Jacob, David H Ledbetter, Jeanette J McCarthy, Michael Ball, Kenneth B Beckman, John W Belmont, Cinnamon S Bloss, Michael F Christman, Andy Cosgrove, Stephen A Damiani, Timothy Danis, Massimo Delledonne, Michael J Dougherty, Joel T Dudley, W Andrew Faucett, Jennifer R Friedman, David H Haase, Tom S Hays, Stu Heilsberg, Jeff Huber, Leah Kaminsky, Nikki Ledbetter, Warren H Lee, Elissa Levin, Ondrej Libiger, Michael Linderman, Richard L Love, David C Magnus, AnneMarie Martland, Susan L McClure, Scott E Megill, Helen Messier, Robert L Nussbaum, Latha Palaniappan, Bradley A Patay, Bradley W Popovich, John Quackenbush, Mark J Savant, Michael M Su, Sharon F Terry, Steven Tucker, William T Wong, Robert C Green
Precision or personalized medicine through clinical genome and exome sequencing has been described by some as a revolution that could transform healthcare delivery, yet it is currently used in only a small fraction of patients, principally for the diagnosis of suspected Mendelian conditions and for targeting cancer treatments. Given the burden of illness in our society, it is of interest to ask how clinical genome and exome sequencing can be constructively integrated more broadly into the routine practice of medicine for the betterment of public health...
2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/26436036/invitro-anti-mycotic-activity-of-hydro-alcoholic-extracts-of-some-indian-medicinal-plants-against-fluconazole-resistant-candida-albicans
#15
Saranya Varadarajan, Malathi Narasimhan, Malaiyandi Malaisamy, Chamundeeswari Duraipandian
BACKGROUND: Candidiasis is one of the most common opportunistic infections caused by Candida albicans. Fluconazole is the drug of choice for prevention and management of this condition. However, the emergence of fluconazole resistant candidal strains has become a major concern. Many herbs like fenugreek, cinnamon, papaya, oregano, garlic are rich in phytochemical constituents known to express antimycotic activity. With the available information, the present research study was carried out to assess the invitro anti-mycotic activity of hydro alcoholic extracts of Trigonella foenum-graecum seeds, Cinnamomum verum bark and Carica papaya leaves and seeds against fluconazole resistant Candida albicans...
August 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26151013/cinnamon-from-the-selection-of-traditional-applications-to-its-novel-effects-on-the-inhibition-of-angiogenesis-in-cancer-cells-and-prevention-of-alzheimer-s-disease-and-a-series-of-functions-such-as-antioxidant-anticholesterol-antidiabetes-antibacterial-antifungal
#16
REVIEW
Rafie Hamidpour, Mohsen Hamidpour, Soheila Hamidpour, Mina Shahlari
The purpose of this article is to use search engines such as PubMed and Scifinder to locate scholarly articles and reports pertaining to Cinnamon ( ròu guì), its novel effects, preparation, analysis, and use in the prevention and treatment of serious illnesses, such as diabetes, cardiovascular diseases, Alzheimer's disease, and cancer. Cinnamon has been used traditionally in food preparations and as an herbal medicine to treat a variety of ailments and their symptoms. Cinnamon is known to have antioxidant, antibacterial, anti-inflammatory, and other therapeutic properties...
April 2015: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/26004731/anticancer-activity-of-cinnamon-tamala-leaf-constituents-towards-human-ovarian-cancer-cells
#17
Durre Shahwar, Sami Ullah, Mohammad Akmal Khan, Naeem Ahmad, Afifa Saeed, Saif Ullah
Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, (1)H and (13)C NMR). Compound 1 exhibited highest cytotoxicity with 90.16 ± 1.06% inhibition (IC50=5.30 x 10(-4) mg/ml) followed by compound 2 (84.40±1.53% inhibition; IC50=8.94 x 10(-3)mg/ml), while compounds 3 and 4 were inactive in the bioassay...
May 2015: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25948588/a-novel-cinnamon-related-natural-product-with-pim-1-inhibitory-activity-inhibits-leukemia-and-skin-cancer
#18
Jong-Eun Kim, Joe Eun Son, Hyein Jeong, Dong Joon Kim, Sang Kwon Seo, Eunjung Lee, Tae Gyu Lim, Jong Rhan Kim, Hanyong Chen, Ann M Bode, Ki Won Lee, Zigang Dong
The Pim-1 kinase regulates cell survival, proliferation, and differentiation and is overexpressed frequently in many malignancies, including leukemia and skin cancer. In this study, we used kinase profiling analysis to demonstrate that 2'-hydroxycinnamicaldehyde (2'-HCA), a compound found in cinnamon, specifically inhibits Pim-1 activity. Cocrystallography studies determined the hydrogen bonding pattern between 2'-HCA and Pim-1. Notably, 2'-HCA binding altered the apo kinase structure in a manner that shielded the ligand from solvent, thereby acting as a gatekeeper loop...
July 1, 2015: Cancer Research
https://www.readbyqxmd.com/read/25747463/postharvest-processing-and-benefits-of-black-pepper-coriander-cinnamon-fenugreek-and-turmeric-spices
#19
REVIEW
S Balasubramanian, P Roselin, K K Singh, John Zachariah, S N Saxena
Spices are prime source for flavor, aroma, and taste in cuisines and play an active role as medicines due to their high antioxidant properties. As medicine or food, the importance of spices cannot be overemphasized. The medicinal values of spices are very well established in treating various ailments like cancer, fever, malaria, stomach offset, nausea, and many more. A spice may be available in several forms: fresh, whole dried, or pre-ground dried which requires further processing to be utilized in the form of value-added product...
July 26, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/25712056/nrf2-dependent-suppression-of-azoxymethane-dextran-sulfate-sodium-induced-colon-carcinogenesis-by-the-cinnamon-derived-dietary-factor-cinnamaldehyde
#20
Min Long, Shasha Tao, Montserrat Rojo de la Vega, Tao Jiang, Qing Wen, Sophia L Park, Donna D Zhang, Georg T Wondrak
The progressive nature of colorectal cancer and poor prognosis associated with the metastatic phase of the disease create an urgent need for the development of more efficacious strategies targeting colorectal carcinogenesis. Cumulative evidence suggests that the redox-sensitive transcription factor Nrf2 (nuclear factor-E2-related factor 2), a master regulator of the cellular antioxidant defence, represents a promising molecular target for colorectal cancer chemoprevention. Recently, we have identified cinnamon, the ground bark of Cinnamomum aromaticum (cassia cinnamon) and Cinnamomum verum (Ceylon cinnamon), as a rich dietary source of the Nrf2 inducer cinnamaldehyde (CA) eliciting the Nrf2-regulated antioxidant response in human epithelial colon cells, conferring cytoprotection against electrophilic and genotoxic insult...
May 2015: Cancer Prevention Research
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