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Cinnamon and cancer

Katarzyna B Leja, Katarzyna Czaczyk
Herbs and spices have been used for food and medicinal purposes for centuries - the first recorded evidence of their use dates back to 1500BC and the Ebers Papyrus, which mentioned spices such as anise, mustard, saffron, cinnamon, and cassia. Now, in the 21st century, a variety of secondary compounds produced by plants are used in many fields of industry, such as food production (to improve taste, to provide vitamins and macro- and microelements, and also to inhibit food spoilage caused by foodborne bacteria), in medicine (in the treatment of various diseases; in chemoprevention and cancer therapy; as a source of natural antimicrobials for the treatment of infectious disease), and in pharmacology and cosmetology (in dietary supplements, and as a result of the demand for preservative-free cosmetics, to reduce the risk of methylparaben allergies)...
October 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
Mitra Hariri, Reza Ghiasvand
Cinnamon (Cinnamomum zeylanicum and Cinnamon cassia), the eternal tree of tropical medicine, belongs to the Lauraceae family and is one of the most important spices used daily by people all over the world. It contains a lot of manganese, iron, dietary fiber, and calcium. Cinnamon contains derivatives, such as cinnamaldehyde, cinnamic acid, cinnamate, and numerous other components such as polyphenols and antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer effects. Several reports have dealt with the numerous properties of cinnamon in the forms of bark, essential oils, bark powder, and phenolic compounds, and each of these properties can play a key role in human health...
2016: Advances in Experimental Medicine and Biology
Ayman I ElKady, Wafaa S Ramadan
AIM: Cis-diammine dichloroplatinum (CDDP) is one of the most important chemotherapeutic agents for cancer treatment. Nonetheless, its notable side effect, nephrotoxicity, undermines its clinical use. The current study was undertaken to evaluate the protective potential of the aqueous extract (AEC) of Cinnamomum cassia (cinnamon) against the cytotoxic effect of CDDP in vitro and to elaborate the molecular mechanism underlying protection. METHODS: MTT assay was performed to assess viability of the normal kidney Vero cells treated with CDDP and/or AEC...
September 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Keqiang Zhang, Ernest S Han, Thanh H Dellinger, Jianming Lu, Sangkil Nam, Richard A Anderson, John H Yim, Wei Wen
Although many anti-VEGF agents are available for cancer treatment, side effects of these agents limit their application for cancer treatment and prevention. Here we studied the potential use of a diet-based agent as an inhibitor for VEGF production. Using a VEGF reporter assay, our data showed that an extract from cinnamon (CE) was a potent inhibitor of VEGF production in human cancer cells and suggested inhibition might be mediated through the suppression of HIF-1α gene expression and protein synthesis. Furthermore, CE treatment was found to inhibit expression and phosphorylation of STAT3 and AKT, which are key factors in the regulation of HIF-1α expression, and significantly reduce angiogenesis potential of cancer cells by migration assay...
February 2017: Molecular Carcinogenesis
Uma Kant Sharma, Amit Kumar Sharma, Abhay K Pandey
BACKGROUND: Excessive production of free radicals has been implicated in many diseases including cancer. They are highly reactive and bring about oxidation of biomolecules i.e., proteins, lipids and nucleic acids which are associated with many degenerative diseases. Natural products acting as antioxidants have ability to neutralize free radicals and their actions and hence they mitigate their harmful effects. The present study was designed to investigate pharmacological properties viz...
May 31, 2016: BMC Complementary and Alternative Medicine
Ta-Wei Chen, Kuen-Daw Tsai, Shu-Mei Yang, Ho-Yiu Wong, Yi-Heng Liu, Jonathan Cherng, Kuo-Shen Chou, Yang-Tz Wang, Janise Cuizon, Jaw-Ming Cherng
Cinnamomum verum is used to make the spice cinnamon and has been used for more than 5000 years by both of the two most ancient forms of medicine in the words: Ayurveda and traditional Chinese herbal medicines for various applications such as adenopathy, rheumatism, dermatosis, dyspepsia, stroke, tumors, elephantiasis, trichomonas, yeast, and virus infections. We evaluated the anticancer effect of cuminaldehyde (CuA), a constituent of the bark of the plant, and its underlying molecular biomarkers associated with carcinogenesis in human lung adenocarcinoma A549 cells...
April 26, 2016: Current Cancer Drug Targets
Masood Sadiq Butt, Ambreen Naz, Muhammad Tauseef Sultan, Mir Muhammad Nasir Qayyum
Contemporary nutrition regime has focused the attention of the researchers on phytochemicals enriched spices to mitigate various oncological threats. Numerous chemopreventive strategies against malignancy have been developed considering the anticancer perspectives of allied nutraceutical constituents. Current evidences have proven an inverse association of spices with that of oncological incidences. The high antioxidant activity of spices derived bioactives triggers the free radicals scavenging ability at cellular level thereby alleviating various metabolic syndromes...
2013: EXCLI journal
Xin-Qing Yang, Hao Zheng, Qing Ye, Rui-Yu Li, Yong Chen
PURPOSE: Impressed by the exceptional anticancer activity of cinnamon, the present study was conducted to elucidate the anticancer potential of essential oil of Cinnamon (EOC). METHODS: EOC was tested against various cell lines (FaDu, Detroit-562 and SCC-25) of head and neck squamous cell carcinoma (HNSCC) using MTT assay. The Hep-2 cell xenograft model was used to assess the positive bio-activity of EOC. EGFR-TK inhibitory assay was also carried out to explain the possible mechanism of action of EOC...
November 2015: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Susan K Delaney, Michael L Hultner, Howard J Jacob, David H Ledbetter, Jeanette J McCarthy, Michael Ball, Kenneth B Beckman, John W Belmont, Cinnamon S Bloss, Michael F Christman, Andy Cosgrove, Stephen A Damiani, Timothy Danis, Massimo Delledonne, Michael J Dougherty, Joel T Dudley, W Andrew Faucett, Jennifer R Friedman, David H Haase, Tom S Hays, Stu Heilsberg, Jeff Huber, Leah Kaminsky, Nikki Ledbetter, Warren H Lee, Elissa Levin, Ondrej Libiger, Michael Linderman, Richard L Love, David C Magnus, AnneMarie Martland, Susan L McClure, Scott E Megill, Helen Messier, Robert L Nussbaum, Latha Palaniappan, Bradley A Patay, Bradley W Popovich, John Quackenbush, Mark J Savant, Michael M Su, Sharon F Terry, Steven Tucker, William T Wong, Robert C Green
Precision or personalized medicine through clinical genome and exome sequencing has been described by some as a revolution that could transform healthcare delivery, yet it is currently used in only a small fraction of patients, principally for the diagnosis of suspected Mendelian conditions and for targeting cancer treatments. Given the burden of illness in our society, it is of interest to ask how clinical genome and exome sequencing can be constructively integrated more broadly into the routine practice of medicine for the betterment of public health...
2016: Expert Review of Molecular Diagnostics
Saranya Varadarajan, Malathi Narasimhan, Malaiyandi Malaisamy, Chamundeeswari Duraipandian
BACKGROUND: Candidiasis is one of the most common opportunistic infections caused by Candida albicans. Fluconazole is the drug of choice for prevention and management of this condition. However, the emergence of fluconazole resistant candidal strains has become a major concern. Many herbs like fenugreek, cinnamon, papaya, oregano, garlic are rich in phytochemical constituents known to express antimycotic activity. With the available information, the present research study was carried out to assess the invitro anti-mycotic activity of hydro alcoholic extracts of Trigonella foenum-graecum seeds, Cinnamomum verum bark and Carica papaya leaves and seeds against fluconazole resistant Candida albicans...
August 2015: Journal of Clinical and Diagnostic Research: JCDR
Rafie Hamidpour, Mohsen Hamidpour, Soheila Hamidpour, Mina Shahlari
The purpose of this article is to use search engines such as PubMed and Scifinder to locate scholarly articles and reports pertaining to Cinnamon ( ròu guì), its novel effects, preparation, analysis, and use in the prevention and treatment of serious illnesses, such as diabetes, cardiovascular diseases, Alzheimer's disease, and cancer. Cinnamon has been used traditionally in food preparations and as an herbal medicine to treat a variety of ailments and their symptoms. Cinnamon is known to have antioxidant, antibacterial, anti-inflammatory, and other therapeutic properties...
April 2015: Journal of Traditional and Complementary Medicine
Durre Shahwar, Sami Ullah, Mohammad Akmal Khan, Naeem Ahmad, Afifa Saeed, Saif Ullah
Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, (1)H and (13)C NMR). Compound 1 exhibited highest cytotoxicity with 90.16 ± 1.06% inhibition (IC50=5.30 x 10(-4) mg/ml) followed by compound 2 (84.40±1.53% inhibition; IC50=8.94 x 10(-3)mg/ml), while compounds 3 and 4 were inactive in the bioassay...
May 2015: Pakistan Journal of Pharmaceutical Sciences
Jong-Eun Kim, Joe Eun Son, Hyein Jeong, Dong Joon Kim, Sang Gwon Seo, Eunjung Lee, Tae Gyu Lim, Jong Rhan Kim, Yengo Raymond Kimbung, Hanyong Chen, Ann M Bode, Ki Won Lee, Zigang Dong
The Pim-1 kinase regulates cell survival, proliferation, and differentiation and is overexpressed frequently in many malignancies, including leukemia and skin cancer. In this study, we used kinase profiling analysis to demonstrate that 2'-hydroxycinnamicaldehyde (2'-HCA), a compound found in cinnamon, specifically inhibits Pim-1 activity. Cocrystallography studies determined the hydrogen bonding pattern between 2'-HCA and Pim-1. Notably, 2'-HCA binding altered the apo kinase structure in a manner that shielded the ligand from solvent, thereby acting as a gatekeeper loop...
July 1, 2015: Cancer Research
S Balasubramanian, P Roselin, K K Singh, John Zachariah, S N Saxena
Spices are prime source for flavor, aroma, and taste in cuisines and play an active role as medicines due to their high antioxidant properties. As medicine or food, the importance of spices cannot be overemphasized. The medicinal values of spices are very well established in treating various ailments like cancer, fever, malaria, stomach offset, nausea, and many more. A spice may be available in several forms: fresh, whole dried, or pre-ground dried which requires further processing to be utilized in the form of value-added product...
July 26, 2016: Critical Reviews in Food Science and Nutrition
Min Long, Shasha Tao, Montserrat Rojo de la Vega, Tao Jiang, Qing Wen, Sophia L Park, Donna D Zhang, Georg T Wondrak
The progressive nature of colorectal cancer and poor prognosis associated with the metastatic phase of the disease create an urgent need for the development of more efficacious strategies targeting colorectal carcinogenesis. Cumulative evidence suggests that the redox-sensitive transcription factor Nrf2 (nuclear factor-E2-related factor 2), a master regulator of the cellular antioxidant defence, represents a promising molecular target for colorectal cancer chemoprevention. Recently, we have identified cinnamon, the ground bark of Cinnamomum aromaticum (cassia cinnamon) and Cinnamomum verum (Ceylon cinnamon), as a rich dietary source of the Nrf2 inducer cinnamaldehyde (CA) eliciting the Nrf2-regulated antioxidant response in human epithelial colon cells, conferring cytoprotection against electrophilic and genotoxic insult...
May 2015: Cancer Prevention Research
Xinyan Bi, Yean Yean Soong, Siang Wee Lim, Christiani Jeyakumar Henry
Phenolic compounds in spices were reportedly found to possess high antioxidant capacities (AOCs), which may prevent or reduce risk of human diseases such as cardiovascular disease, cancer and diabetes. The potential AOC of Chinese five-spice powder (consist of Szechuan pepper, fennel seed, cinnamon, star anise and clove) with varying proportion of individual spice ingredients was investigated through four standard methods. Our results suggest that clove is the major contributor to the AOC of the five-spice powder whereas the other four ingredients contribute to the flavour...
May 2015: International Journal of Food Sciences and Nutrition
V Assadollahi, M Gholami, A Zendedel
OBJECTIVE: The aim of this study was to evaluate the effect of C. zeylanicum aqueous extract on cell growth in the human myelocytic leukemia cell line (THP-1). BACKGROUND: Today, application of Cinnamon for treatment of cancer investigates extensively. Cinnamon has antioxidant, anti-apoptotic and anti-inflammatory properties. METHODS: In this experimental study, THP-1 was incubated in 2, 1, 0.1 and 0.01 mg/ml C. zeylanicum solutions for 24, 48 and 72 hours...
2015: Bratislavské Lekárske Listy
Kirtee D Wani, Brijesh S Kadu, Prakash Mansara, Preeti Gupta, Avinash V Deore, Rajeev C Chikate, Pankaj Poddar, Sanjay D Dhole, Ruchika Kaul-Ghanekar
Cinnamaldehyde, the bioactive component of the spice cinnamon, and its derivatives have been shown to possess anti-cancer activity against various cancer cell lines. However, its hydrophobic nature invites attention for efficient drug delivery systems that would enhance the bioavailability of cinnamaldehyde without affecting its bioactivity. Here, we report the synthesis of stable aqueous suspension of cinnamaldehyde tagged Fe3O4 nanoparticles capped with glycine and pluronic polymer (CPGF NPs) for their potential application in drug delivery and hyperthermia in breast cancer...
2014: PloS One
Brinda K Rana, Burcu F Darst, Cinnamon Bloss, Pei-An Betty Shih, Colin Depp, Caroline M Nievergelt, Matthew Allison, J Kellogg Parsons, Nicholas Schork, Dilip V Jeste
OBJECTIVE: Optimism and resilience promote health and well-being in older adults, and previous reports suggest that these traits are heritable. We examined the association of selected single-nucleotide polymorphisms (SNPs) with optimism and resilience in older adults. DESIGN: Candidate gene association study that was a follow-on at the University of California, San Diego, sites of two NIH-funded multi-site longitudinal investigations: Women's Health Initiative (WHI) and SELenium and vitamin E Cancer prevention Trial (SELECT)...
October 2014: American Journal of Geriatric Psychiatry
Liang-Tzung Lin, Shu-Jing Wu, Chun-Ching Lin
Hepatocellular carcinoma (HCC) has long been one of the most important causes of cancer mortality in the world. Many natural products and traditional herbal medicines have been used to treat HCC in Asian countries such as Japan, Korea, Taiwan, and China. The present review aims to describe the anticancer properties and apoptotic mechanisms of cinnamaldehyde, the bioactive ingredient isolated from cinnamon trees, and the herbal prescription Huang-Lian-Jie-Du-Tang ( Huáng Lián Jiě Dú Tang; HLJDT) against human hepatoma cells in vitro and in vivo...
October 2013: Journal of Traditional and Complementary Medicine
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