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https://www.readbyqxmd.com/read/28749439/effects-of-melatonin-on-early-pregnancy-in-mouse-involving-the-regulation-of-star-cyp11a1-and-ihh-expression
#1
Shengyu Guan, Lu Xie, Teng Ma, Dongying Lv, Wang Jing, Xiuzhi Tian, Yukun Song, Zhiping Liu, Xianghong Xiao, Guoshi Liu
To test whether melatonin plays an important role in the process of early pregnancy, melatonin was given in drinking water to pregnant mice at different gestation stages. These included mice who were given melatonin 14 days prior to their successful mating (confirmed by vaginal plug) (Group A), after successful mating (Group B), and 14 days prior to and until after successful mating (Group C). Melatonin administration significantly enhanced serum as well as ovarian melatonin levels in the mice. It was observed that melatonin did not affect the natural estrous of mice...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28748402/methodology-for-the-identification-of-vulnerable-asylum-seekers
#2
Sindi Visentin, Guido Pelletti, Thomas Bajanowski, Santo Davide Ferrara
Asylum seekers often experience situations of vulnerability, being frequently exposed to a heightened risk of harm, and thus require special care, support and protection. The categories of "vulnerable persons", identified by International Legislation, and an individual's classification as a "vulnerable asylum seeker", have important implications in the reception procedures, in the decision-making phase and in the definition of therapeutic needs and rehabilitation. The Istanbul Protocol, the first international guideline approved by the United Nations and applied in different contexts, is not applicable for the assessment of the totality of the conditions (medical and otherwise), and therefore, the identification and assessment of conditions of vulnerability is largely delegated to questionnaires administered by non-medical personnel...
July 26, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28748106/a-feasibility-study-of-a-theory-based-intervention-to-improve-appropriate-polypharmacy-for-older-people-in-primary-care
#3
Cathal A Cadogan, Cristín Ryan, Gerard J Gormley, Jill J Francis, Peter Passmore, Ngaire Kerse, Carmel M Hughes
BACKGROUND: A general practitioner (GP)-targeted intervention aimed at improving the prescribing of appropriate polypharmacy for older people was previously developed using a systematic, theory-based approach based on the UK Medical Research Council's complex intervention framework. The primary intervention component comprised a video demonstration of a GP prescribing appropriate polypharmacy during a consultation with an older patient. The video was delivered to GPs online and included feedback emphasising the positive outcomes of performing the behaviour...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28747662/inference-of-neuronal-functional-circuitry-with-spike-triggered-non-negative-matrix-factorization
#4
Jian K Liu, Helene M Schreyer, Arno Onken, Fernando Rozenblit, Mohammad H Khani, Vidhyasankar Krishnamoorthy, Stefano Panzeri, Tim Gollisch
Neurons in sensory systems often pool inputs over arrays of presynaptic cells, giving rise to functional subunits inside a neuron's receptive field. The organization of these subunits provides a signature of the neuron's presynaptic functional connectivity and determines how the neuron integrates sensory stimuli. Here we introduce the method of spike-triggered non-negative matrix factorization for detecting the layout of subunits within a neuron's receptive field. The method only requires the neuron's spiking responses under finely structured sensory stimulation and is therefore applicable to large populations of simultaneously recorded neurons...
July 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28747274/efficacy-safety-and-effect-on-sexual-behaviour-of-on-demand-pre-exposure-prophylaxis-for-hiv-in-men-who-have-sex-with-men-an-observational-cohort-study
#5
Jean-Michel Molina, Isabelle Charreau, Bruno Spire, Laurent Cotte, Julie Chas, Catherine Capitant, Cecile Tremblay, Daniela Rojas-Castro, Eric Cua, Armelle Pasquet, Camille Bernaud, Claire Pintado, Constance Delaugerre, Luis Sagaon-Teyssier, Soizic Le Mestre, Christian Chidiac, Gilles Pialoux, Diane Ponscarme, Julien Fonsart, David Thompson, Mark A Wainberg, Veronique Doré, Laurence Meyer
BACKGROUND: Data for on-demand pre-exposure prophylaxis (PrEP) are scarce. We implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour. METHODS: We invited men and transgender women who have sex with men, previously enrolled in the randomised placebo-controlled ANRS IPERGAY trial at seven sites (six in France and one in Canada), to participate in an open-label extension with on-demand tenofovir disoproxil fumarate (300 mg) and emtricitabine (200 mg) to be taken before and after sexual intercourse...
July 21, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28746815/higher-order-areas-of-the-mouse-visual-cortex
#6
Lindsey L Glickfeld, Shawn R Olsen
The brain has evolved to transform sensory information in the environment into neural representations that can be used for perception and action. Higher-order sensory cortical areas, with their increasingly complex receptive fields and integrative properties, are thought to be critical nodes for this function. This is especially true in the primate visual cortex, in which functionally specialized areas are engaged in parallel streams to support diverse computations. Recent anatomical and physiological studies of the mouse visual cortex have revealed a similarly complex network of specialized higher-order areas...
July 26, 2017: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28746514/experience-of-mothers-of-premature-babies-from-birth-to-discharge-notes-of-field-journals
#7
Marly Veronez, Nataly Alves Barbosa Borghesan, Darci Aparecida Martins Corrêa, Ieda Harumi Higarashi
Objective: To describe the maternal care process mediated by nurses during the period of hospitalisation and discharge of premature babies. Method: This is a descriptive, exploratory, and qualitative study, using the methodological framework of convergent care research, with seven mothers of premature babies admitted to a hospital in southern Brazil, from October to December 2011. Data from the mother's daily journals were submitted to content analysis. Results: Analysis resulted in three categories portraying the path and the adaptation process of the mothers to the care of their premature babies, from preparation for discharge to overcoming her fears and insecurities concerning home care...
July 20, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28745941/veterans-preferences-for-remote-management-of-chronic-conditions
#8
Erica Sedlander, Katherine C Barboza, Ashley Jensen, Nicole Skursky, Katelyn Bennett, Scott Sherman, Mark Schwartz
BACKGROUND: The Veterans Health Administration (VA) is investing considerable resources into providing remote management care to patients for disease prevention and management. Remote management includes online patient portals, e-mails between patients and providers, follow-up phone calls, and home health devices to monitor health status. However, little is known about patients' attitudes and preferences for this type of care. This qualitative study was conducted to better understand patient preferences for receiving remote care...
July 26, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28745638/localization-of-odorant-receptor-genes-in-locust-antennae-by-rna-in-situ-hybridization
#9
Xiao Xu, Yinwei You, Long Zhang
Insects have evolved sophisticated olfactory reception systems to sense exogenous chemical signals. These chemical signals are transduced by Olfactory Receptor Neurons (ORNs) housed in hair-like structures, called chemosensilla, of the antennae. On the ORNs' membranes, Odorant Receptors (ORs) are believed to be involved in odor coding. Thus, being able to identify genes localized to the ORNs is necessary to recognize OR genes, and provides a fundamental basis for further functional in situ studies. The RNA expression levels of specific ORs in insect antennae are very low, and preserving insect tissue for histology is challenging...
July 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28745137/exploring-the-value-proposition-of-primary-care-for-safety-net-patients-who-utilize-emergency-departments-to-address-unmet-needs
#10
Kimberly R Enard, Deborah M Ganelin
BACKGROUND: An underlying assumption of strategies intended to promote appropriate primary care over emergency department (ED) use for ongoing health care needs is that patients will understand the "value proposition" of primary care: that they will receive specific benefits from primary care providers over and above what they receive from EDs. However, there is evidence that this value proposition may be unclear to safety-net patients. The goals of this study are to describe factors motivating ED use for low-acuity conditions; describe similarities and differences in usual source of care (USOC) experiences, by ED versus non-ED setting; and assess awareness and perceptions of the patient-centered medical home (PCMH) concept among safety-net patients...
July 1, 2017: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/28745018/a-comparison-between-linguistic-skills-and-socio-communicative-abilities-in-williams-syndrome
#11
P Alfieri, D Menghini, L Marotta, L De Peppo, L Ravà, F Salvaguardia, C Varuzza, S Vicari
BACKGROUND: Individuals with Williams syndrome (WS) show a disharmonic linguistic profile with a clear pattern of strengths and weaknesses. Despite their sociable nature, atypical socio-communicative abilities and deficits in communication and relationship with others have been found. AIM: The aim of the present study was to investigate whether linguistic skills (LS) were in line with the pragmatic and social use of language and the cognitive development of 32 individuals with WS (18 boys and 14 girls) with a mean chronological age of 12...
July 26, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28744759/do-verbal-children-with-autism-comprehend-gesture-as-readily-as-typically-developing-children
#12
Nevena Dimitrova, Şeyda Özçalışkan, Lauren B Adamson
Gesture comprehension remains understudied, particularly in children with autism spectrum disorder (ASD) who have difficulties in gesture production. Using a novel gesture comprehension task, Study 1 examined how 2- to 4-year-old typically-developing (TD) children comprehend types of gestures and gesture-speech combinations, and showed better comprehension of deictic gestures and reinforcing gesture-speech combinations than iconic/conventional gestures and supplementary gesture-speech combinations at each age...
July 25, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28743725/altered-balance-of-receptive-field-excitation-and-suppression-in-visual-cortex-of-amblyopic-macaque-monkeys
#13
Luke E Hallum, Christopher Shooner, Romesh D Kumbhani, Jenna G Kelly, Virginia García-Marín, Najib J Majaj, J Anthony Movshon, Lynne Kiorpes
In amblyopia, a visual disorder caused by abnormal visual experience during development, the amblyopic eye loses visual sensitivity while the other (fellow) eye is largely unaffected. Binocular vision in amblyopes is often disrupted by interocular suppression. We used 96-electrode arrays to record neurons and neuronal groups in areas V1 and V2 of 6 female monkeys (Macaca nemestrina) made amblyopic by artificial strabismus or anisometropia in early life, as well as 2 visually normal female monkeys (Macaca nemestrina)...
July 25, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28743250/child-and-parent-perspectives-on-healthier-side-dishes-and-beverages-in-restaurant-kids-meals-results-from-a-national-survey-in-the-united-states
#14
Eleanor T Shonkoff, Stephanie Anzman-Frasca, Vanessa M Lynskey, Grace Chan, Meaghan E Glenn, Christina D Economos
BACKGROUND: Children frequently consume foods from restaurants; considering the quick-service sector alone, 1/3 of children eat food from these restaurants on a given day, and among these consumers, 1/3 of their daily calories come from fast food. Restaurant foods and beverages are second only to grocery store foods and beverages in their contribution to total energy intake of U.S. 4- to 11-year-olds. Shifting their restaurant consumption in healthier directions could have a positive impact on child health...
July 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28743055/the-influence-of-viscous-and-conducting-liquid-on-the-characteristics-of-the-slot-acoustic-wave
#15
I A Borodina, B D Zaitsev, A A Teplykh
The influence of the liquid with the different values of conductivity, permittivity, and viscosity on the characteristics of the slot mode in the structure consisting of delay line with propagating shear - horizontal acoustic wave of zero order (SH0) and upper piezoelectric plate separated by the air gap was experimentally investigated. The delay line made of the Y-X lithium niobate plate 0.2mm thick contained two interdigital transducers for the excitation and reception of acoustic wave in the frequency range of 2...
July 18, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28742032/architecture-of-an-ultrasound-system-for-continuous-real-time-high-frame-rate-imaging
#16
Enrico Boni, Luca Bassi, Alessandro Dallai, Valentino Meacci, Alessandro Ramalli, Monica Scaringella, Francesco Guidi, Stefano Ricci, Piero Tortoli
High frame rate (HFR) imaging methods based on the transmission of defocused or plane waves rather than focused beams are increasingly popular. However, the production of HFR images poses severe requirements both in the transmission and the reception sections of ultrasound scanners. In particular, major technical difficulties arise if the images must be continuously produced in real-time, i.e. without any acquisition interruption nor loss of data. This paper presents the implementation of the real-time HFR compounded imaging application in the ULA-OP 256 research platform...
July 20, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28740234/virgin-queen-attraction-toward-males-in-honey-bees
#17
Florian Bastin, Hanna Cholé, Grégory Lafon, Jean-Christophe Sandoz
Although the honeybee is a crucial agricultural agent and a prominent scientific model organism, crucial aspects of its reproductive behaviour are still unknown. During the mating season, honeybee males, the drones, gather in congregations 10-40 m above ground. Converging evidence suggests that drones emit a pheromone that can attract other drones, thereby increasing the size of the congregation. Virgin queens join the vicinity of the congregation after it has formed, and mate with as many as 20 males in mid-air...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739527/deconstructing-the-cortical-column-in-the-barrel-cortex
#18
Kevin Fox
The question of what function is served by the cortical column has occupied neuroscientists since its original description some 60 years ago. The answer seems tractable in the somatosensory cortex when considering the inputs to the cortical column and the early stages of information processing, but quickly breaks down once the multiplicity of output streams and their sub-circuits are brought into consideration. This article describes the early stages of information processing in the barrel cortex, through generation of the centre and surround receptive field components of neurones that subserve integration of multi whisker information, before going on to consider the diversity of properties exhibited by the layer 5 output neurones...
July 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28739392/large-improvement-of-rf-transmission-efficiency-and-reception-sensitivity-for-human-in-vivo-31-p-mrs-imaging-using-ultrahigh-dielectric-constant-materials-at-7t
#19
Byeong-Yeul Lee, Xiao-Hong Zhu, Sebastian Rupprecht, Michael T Lanagan, Qing X Yang, Wei Chen
In vivo(31)P MRS provides a unique and important imaging tool for studying high-energy phosphate metabolism and bioenergetics noninvasively. However, compared to (1)H MRS, (31)P MRS with a relatively low gyromagnetic ratio (γ) has a lower and limited sensitivity even at ultrahigh field. The proof of concept has been recently demonstrated that the use of high dielectric constant (HDC) materials between RF coil and object sample could increase MRI signal and reduce required RF transmission power for reaching the same RF pulse flip angle in the region of interest...
July 21, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28738138/vocabulary-facilitates-speech-perception-in-children-with-hearing-aids
#20
Kelsey E Klein, Elizabeth A Walker, Benjamin Kirby, Ryan W McCreery
Purpose: We examined the effects of vocabulary, lexical characteristics (age of acquisition and phonotactic probability), and auditory access (aided audibility and daily hearing aid [HA] use) on speech perception skills in children with HAs. Method: Participants included 24 children with HAs and 25 children with normal hearing (NH), ages 5-12 years. Groups were matched on age, expressive and receptive vocabulary, articulation, and nonverbal working memory. Participants repeated monosyllabic words and nonwords in noise...
July 24, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
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