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https://www.readbyqxmd.com/read/29352045/eliminating-glutamatergic-input-onto-horizontal-cells-changes-the-dynamic-range-and-receptive-field-organization-of-mouse-retinal-ganglion-cells
#1
Sebastian Ströh, Christian Puller, Sebastian Swirski, Maj-Britt Hölzel, Lea I S van der Linde, Jasmin Segelken, Konrad Schultz, Christoph Block, Hannah Monyer, Klaus Willecke, Reto Weiler, Martin Greschner, Ulrike Janssen-Bienhold, Karin Dedek
In the mammalian retina, horizontal cells receive glutamatergic inputs from many rod and cone photoreceptors and return feedback signals to them, thereby changing photoreceptor glutamate release in a light-dependent manner. Horizontal cells also provide feedforward signals to bipolar cells. It is unclear, however, how horizontal cell signals also affect the temporal, spatial and contrast tuning in retinal output neurons, the ganglion cells. To study this, we generated a genetically modified mouse line in which we eliminated the light dependency of feedback by deleting glutamate receptors from mouse horizontal cells...
January 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29351604/evaluation-of-results-based-financing-in-the-republic-of-the-congo-a-comparison-group-pre-post-study
#2
Wu Zeng, Donald S Shepard, Jean de Dieu Rusatira, Aaron P Blaakman, Bernice M Nsitou
Results-based financing (RBF) has been advocated and increasingly scaled up in low- and middle-income countries to increase utilization and quality of key primary care services, thereby reducing maternal and child mortality rates. This pilot RBF study in the Republic of the Congo from 2012 to 2014 used a quasi-experimental research design. The authors conducted pre- and post-household surveys and gathered health facility services data from both intervention and comparison groups. Using a difference-in-differences approach, the study evaluated the impact of RBF on maternal and child health services...
January 16, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29351584/the-roles-of-left-versus-right-anterior-temporal-lobes-in-semantic-memory-a-neuropsychological-comparison-of-postsurgical-temporal-lobe-epilepsy-patients
#3
Grace E Rice, Helen Caswell, Perry Moore, Paul Hoffman, Matthew A Lambon Ralph
The presence and degree of specialization between the anterior temporal lobes (ATLs) is a key issue in debates about the neural architecture of semantic memory. Here, we comprehensively assessed multiple aspects of semantic cognition in a large group of postsurgical temporal lobe epilepsy (TLE) patients with left versus right anterior temporal lobectomy (n = 40). Both subgroups showed deficits in expressive and receptive verbal semantic tasks, word and object recognition, naming and recognition of famous faces and perception of faces and emotions...
January 17, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29351038/early-reading-abilities-of-bilingual-children-with-nonsyndromic-orofacial-clefts
#4
Michelle Heng Yue Cheong, Selena Ee-Li Young, Dawn Patricia Chuan Yu Young, Mary Lay Choo Lee, Susan Jane Rickard Liow
OBJECTIVE: To investigate the early reading abilities, and related cognitive-linguistic processes, in bilingual children with nonsyndromic cleft lip and/or palate (CL/P), and to identify deficits that might be amenable to intervention. DESIGN AND PARTICIPANTS: Bilingual participants with CL/P aged 5 to 6 years who were English-dominant ( n=17) or Mandarin-dominant ( n=18) were recruited using consecutive sampling from a national cleft treatment center and matched pairwise to a sample of typically developing (TD) children on language dominance, age, and socioeconomic status...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29350112/a-comparison-of-hiv-risk-behaviors-between-young-black-cisgender-men-who-have-sex-with-men-and-young-black-transgender-women-who-have-sex-with-men
#5
Richard A Crosby, Laura F Salazar, Brandon Hill, Leandro Mena
This study compared sexually transmitted infection (STI)-associated risks between young Black cisgender men who have sex with men (YBMSM) and young Black transwomen who have sex with men (YBTWSM). Comparisons pertained to: (1) prevalence of infections; (2) sexual risk; (3) partner-related risks; and (4) socioeconomic marginalization. YBMSM (n = 577) and YBTWSM (n = 32) were recruited from an STI clinic in the USA. Volunteers completed a computer-assisted self-interview and medical records were abstracted for STI/HIV information...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29347986/untapped-aspects-of-mass-media-campaigns-for-changing-health-behaviour-towards-non-communicable-diseases-in-bangladesh
#6
Reshman Tabassum, Guenter Froeschl, Jonas P Cruz, Paolo C Colet, Sukhen Dey, Sheikh Mohammed Shariful Islam
In recent years, non-communicable diseases (NCDs) have become epidemic in Bangladesh. Behaviour changing interventions are key to prevention and management of NCDs. A great majority of people in Bangladesh have low health literacy, are less receptive to health information, and are unlikely to embrace positive health behaviours. Mass media campaigns can play a pivotal role in changing health behaviours of the population. This review pinpoints the role of mass media campaigns for NCDs and the challenges along it, whilst stressing on NCD preventive programmes (with the examples from different countries) to change health behaviours in Bangladesh...
January 18, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29346447/pik3ca-is-required-for-mouse-uterine-gland-development-and-pregnancy
#7
Hye Jin Chang, Hee Sung Shin, Tae Hoon Kim, Jung-Yoon Yoo, Hanna E Teasley, Jean J Zhao, Un-Hwan Ha, Jae-Wook Jeong
The PI3K/AKT signaling pathway plays a critical role in the maintenance of equilibrium between cell survival and apoptosis. The Pik3ca gene is mutated in a range of human cancers. It has been found to be oncogenic, and mutations lead to constitutive activation of the PI3K/AKT pathway. The expression patterns of PIK3CA proteins in the uterus of mice during early pregnancy indicate that it may play a role in the regulation of glandular epithelial cells, which is required to support uterine receptivity. To further investigate the role of Pik3ca in uterine function, Pik3ca was conditionally ablated only in the PGR-positive cells (Pgrcre/+Pik3caf/f; Pik3cad/d)...
2018: PloS One
https://www.readbyqxmd.com/read/29343189/translating-ancient-alchemy-fragments-of-graeco-egyptian-alchemy-in-arabic-compendia
#8
Matteo Martelli
Translation played a vital role in the development and transfer of alchemy in Antiquity and the Early Middle Ages. Since its origins in Graeco-Roman Egypt, alchemy was encapsulated in Greek texts which allegedly relied on Persian or Egyptian sources. Later, a variety of Greek and Byzantine writings were translated into Syriac and Arabic, and these translations were in turn fragmented and disseminated in later Arabic compendia. This paper will first review the main phases of this historical process of transmission of alchemy from one language and culture to another...
January 17, 2018: Ambix
https://www.readbyqxmd.com/read/29343055/genetically-encoded-circuit-for-remote-regulation-of-cell-migration-by-magnetic-fields
#9
Abdullah Al Mosabbir, Kevin Truong
Magneto-reception can be generally defined as the ability to transduce the effects of a magnetic field into a cellular response. Magnetic stimulation at the cellular level is particularly attractive due to its ability for deep penetration and minimal invasiveness, allowing remote regulation of engineered biological processes. Previously, a magnetic-responsive genetic circuit was engineered using the transient receptor potential vanilloid 1 (TRPV1) and the iron containing ferritin protein (i.e. the TF circuit)...
January 17, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29341463/synthetic-phonics-and-decodable-instructional-reading-texts-how-far-do-these-support-poor-readers
#10
Ruth Maria Price-Mohr, Colin Bernard Price
This paper presents data from a quasi-experimental trial with paired randomisation that emerged during the development of a reading scheme for children in England. This trial was conducted with a group of 12 children, aged 5-6, and considered to be falling behind their peers in reading ability and a matched control group. There were two intervention conditions (A: using mixed teaching methods and a high percentage of non-phonically decodable vocabulary; P: using mixed teaching methods and low percentage of non-decodable vocabulary); allocation to these was randomised...
January 17, 2018: Dyslexia: the Journal of the British Dyslexia Association
https://www.readbyqxmd.com/read/29340631/a-better-understanding-of-ambulance-personnel-s-attitude-towards-real-time-resuscitation-feedback
#11
Peter Brinkrolf, Roman Lukas, Ulf Harding, Sebastian Thies, Joachim Gerss, Hugo Van Aken, Hans Lemke, Udo Schniedermeier, Andreas Bohn
Objective: High-quality chest compressions during cardiopulmonary resuscitation (CPR) play a significant role in surviving cardiac arrest. Chest-compression quality can be measured and corrected by real-time CPR feedback devices, which are not yet commonly used. This article looks at the acceptance of such systems in comparison of equipped and unequipped personnel. Design: Two groups of emergency medical services' (EMS) personnel were interviewed using standardized questionnaires...
January 11, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29339664/cenesthopathy-and-subjective-cognitive-complaints-an-exploratory-study-in-schizophrenia
#12
Natalia Jimeno, Martin L Vargas
BACKGROUND/AIMS: Cenesthopathy is mainly associated with schizophrenia; however, its neurobiological basis is nowadays unclear. The general objective was to explore clinical correlates of cenesthopathy and subjective cognitive complaints in schizophrenia. METHODS: Participants (n = 30) meeting DSM-IV criteria for psychotic disorder were recruited from a psychiatry unit and assessed with: Association for Methodology and Documentation in Psychiatry (AMDP) system, Positive and Negative Syndrome Scale, Frankfurt Complaint Questionnaire (FCQ), and the Bonn Scale for the Assessment of Basic Symptoms (BSABS)...
January 16, 2018: Psychopathology
https://www.readbyqxmd.com/read/29338577/modeling-sluggishness-in-binaural-unmasking-of-speech-for-maskers-with-time-varying-interaural-phase-differences
#13
Christopher F Hauth, Thomas Brand
In studies investigating binaural processing in human listeners, relatively long and task-dependent time constants of a binaural window ranging from 10 ms to 250 ms have been observed. Such time constants are often thought to reflect "binaural sluggishness." In this study, the effect of binaural sluggishness on binaural unmasking of speech in stationary speech-shaped noise is investigated in 10 listeners with normal hearing. In order to design a masking signal with temporally varying binaural cues, the interaural phase difference of the noise was modulated sinusoidally with frequencies ranging from 0...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/29336125/association-of-chronic-subjective-tinnitus-with-neuro-cognitive-performance
#14
Sunita Gudwani, Sanjay K Munjal, Naresh K Panda, Adarsh Kohli
INTRODUCTION: Chronic subjective tinnitus is associated with cognitive disruptions affecting perception, thinking, language, reasoning, problem solving, memory, visual tasks (reading) and attention. OBJECTIVE: To evaluate existence of any association between tinnitus parameters and neuropsychological performance to explain cognitive processing. MATERIALS AND METHODS: Study design was prospective, consisting 25 patients with idiopathic chronic subjective tinnitus and gave informed consent before planning their treatment...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29336102/behavioural-responses-of-the-yellow-emitting-annelid-tomopteris-helgolandica-to-photic-stimuli
#15
Anaïd Gouveneaux, Marie-Charlotte Gielen, Jérôme Mallefet
In contrast to most mesopelagic bioluminescent organisms specialised in the emission and reception of blue light, the planktonic annelid Tomopteris helgolandica produces yellow light. This unusual feature has long been suggested to serve for intraspecific communication. Yet, this virtually admitted hypothesis has never been tested. In this behavioural study of spectral colour sensitivity, we first present an illustrated repertoire of the postures and action patterns described by captive specimens. Then video tracking and motion analysis are used to quantify the behavioural responses of singled out worms to photic stimuli imitating intraspecific (yellow) or interspecific (blue) bioluminescent signals...
January 16, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29335465/the-high-concentration-of-progesterone-is-harmful-for-endometrial-receptivity-and-decidualization
#16
Yu-Xiang Liang, Li Liu, Zhi-Yong Jin, Xiao-Huan Liang, Yong-Sheng Fu, Xiao-Wei Gu, Zeng-Ming Yang
Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics. However, there are limited solid evidences available for the optimal timing and dose of progesterone therapy, especially for the possible adverse effects on implantation and decidualization when progesterone is administrated empirically. In our study, mouse models were used to examine effects of excess progesterone on embryo implantation and decidualization...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335126/-reception-of-the-patient-in-psychiatry-overcoming-the-narcissistic-test-of-the-caregiver
#17
Frédéric Gelly
The theme of the encounter is addressed through the question of the reception of the patient. This encounter forces the caregiver to consider his or her own identity faced with the patient, to adjustments which can elude narcissistic doubts by resorting to the standardisation of care. Possible ways for the construction of a joint project are then considered. A 'common illusion' of care, which ensures that the encounter, a prelude to the possibility of care, is achieved.
January 2018: Soins. Psychiatrie
https://www.readbyqxmd.com/read/29335124/-the-reception-a-prerequisite-of-the-encounter-a-political-question
#18
Patrick Touzet
The reception of a patient in psychiatry is a stage which consists of more than a single initial contact between a person suffering psychologically and a caregiver. This time can open the way to an encounter, without which a care relationship cannot be established. The reception as a paradigm of psychiatric care questions the concept of this care, at a time when caregivers cannot avoid the question of their political engagement.
January 2018: Soins. Psychiatrie
https://www.readbyqxmd.com/read/29334205/overexpression-of-endometrial-estrogen-receptor-alpha-in-the-window-of-implantation-in-women-with-unexplained-infertility
#19
Mehran Dorostghoal, Hamid-O-Allah Ghaffari, Farideh Marmazi, Narjes Keikhah
Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during implantation may be a critical event that coincides with the expression of specific genes and the formation of a receptive endometrium. The aim of the present study was to assess the expression of ER-α in the mid-secretory phase in the endometrium of women with unexplained infertility...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29331450/mapping-stimulus-feature-selectivity-in-macaque-v1-by-two-photon-ca2-imaging-encoding-model-analysis-of-fluorescence-responses-to-natural-movies
#20
REVIEW
Koji Ikezoe, Mahya Amano, Shinji Nishimoto, Ichiro Fujita
In vivo calcium (Ca2+) imaging using two-photon microscopy allows activity to be monitored simultaneously from hundreds of individual neurons within a local population. While this allows us to gain important insights into how cortical neurons represent sensory information, factors such as photo-bleaching of the Ca2+ indicator limit imaging duration (and thus the numbers of stimuli that can be tested), which in turn hampers the full characterization of neuronal response properties. Here, we demonstrate that using an encoding model combined with presentation of natural movies results in detailed characterization of receptive field (RF) properties despite the relatively short time for data collection...
January 10, 2018: NeuroImage
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