So Sampei, Hideshi Okada, Hiroyuki Tomita, Chihiro Takada, Kodai Suzuki, Takamasa Kinoshita, Ryo Kobayashi, Hirotsugu Fukuda, Yuki Kawasaki, Ayane Nishio, Hirohisa Yano, Isamu Muraki, Yohei Fukuda, Keiko Suzuki, Nagisa Miyazaki, Takatomo Watanabe, Tomoaki Doi, Takahiro Yoshida, Akio Suzuki, Shozo Yoshida, Shigeki Kushimoto, Shinji Ogura
In diabetes mellitus (DM) patients, the morbidity of infectious disease is increased, and these infections can easily progress from local to systemic infection. Sepsis is a characteristic of organ failure related to microcirculation disorders resulting from endothelial cell injury, whose most frequent comorbidity in patients is DM. The aim of the present study was to evaluate the influence of infection on DM-induced microvascular damage on inflammation and pulmonary endothelial structure using an experimental endotoxemia model...
2021: Frontiers in Cell and Developmental Biology