keyword
https://read.qxmd.com/read/38456329/qi-dan-dihuang-decoction-ameliorates-renal-fibrosis-in-diabetic-rats-via-p38mapk-akt-mtor-signaling-pathway
#1
JOURNAL ARTICLE
Liuyan Kuang, Yanting You, Jieying Qi, Jieyu Chen, Xinghong Zhou, Shuai Ji, Jingru Cheng, Hiu Yee Kwan, Pingping Jiang, Xiaomin Sun, Mengting Su, Ming Wang, Wenxiao Chen, Ren Luo, Xiaoshan Zhao, Lin Zhou
CONTEXT: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood. OBJECTIVE: This study reveals the mechanism by which QDD ameliorates DKD. MATERIALS AND METHODS: The compounds in QDD were identified by high-performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS). Key targets and signaling pathways were screened through bioinformatics...
March 8, 2024: Environmental Toxicology
https://read.qxmd.com/read/38147550/angptl4-binds-to-the-leptin-receptor-to-regulate-ectopic-bone-formation
#2
JOURNAL ARTICLE
Hongling Hu, Sheng Luo, Pinglin Lai, Mingqiang Lai, Linlin Mao, Sheng Zhang, Yuanjun Jiang, Jiaxin Wen, Wu Zhou, Xiaolin Liu, Liang Wang, Minjun Huang, Yanjun Hu, Xiaoyang Zhao, Laixin Xia, Weijie Zhou, Yu Jiang, Zhipeng Zou, Anling Liu, Bin Guo, Xiaochun Bai
Leptin protein was thought to be unique to leptin receptor (LepR), but the phenotypes of mice with mutation in LepR [ db/db (diabetes)] and leptin [ ob/ob (obese)] are not identical, and the cause remains unclear. Here, we show that db/db , but not ob/ob , mice had defect in tenotomy-induced heterotopic ossification (HO), implicating alternative ligand(s) for LepR might be involved. Ligand screening revealed that ANGPTL4 (angiopoietin-like protein 4), a stress and fasting-induced factor, was elicited from brown adipose tissue after tenotomy, bound to LepR on PRRX1+ mesenchymal cells at the HO site, thus promotes chondrogenesis and HO development...
January 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38107390/ginsenoside-rg5-promotes-wound-healing-in-diabetes-by-reducing-the-negative-regulation-of-slc7a11-on-the-efferocytosis-of-dendritic-cells
#3
JOURNAL ARTICLE
Wei Xia, Zongdong Zhu, Song Xiang, Yi Yang
UNLABELLED: Background: ginsenoside Rg5 is a rare ginsenoside with known hypoglycemic effects in diabetic mice. This study aimed to explore the effects of ginsenoside Rg5 on skin wound-healing in the Lepr db/db mutant ( db/db ) mice (C57BL/KsJ background) model and the underlying mechanisms. METHODS: Seven-week-old male C57BL/6J, SLC7A11 -knockout (KO), the littermate wild-type (WT), and db/db mice were used for in vivo and ex vivo studies. RESULTS: Ginsenoside Rg5 provided through oral gavage in db/db mice significantly alleviated the abundance of apoptotic cells in the wound areas and facilitated skin wound healing...
November 2023: Journal of Ginseng Research
https://read.qxmd.com/read/38031839/thrombosis-in-the-coronary-microvasculature-impairs-cardiac-relaxation-and-induces-diastolic-dysfunction
#4
JOURNAL ARTICLE
Paul Rouault, Sarah Guimbal, Lauriane Cornuault, Célia Bourguignon, Ninon Foussard, Philippe Alzieu, Frank Choveau, David Benoist, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault
BACKGROUND: Heart failure with preserved ejection fraction is proposed to be caused by endothelial dysfunction in cardiac microvessels. Our goal was to identify molecular and cellular mechanisms underlying the development of cardiac microvessel disease and diastolic dysfunction in the setting of type 2 diabetes. METHODS: We used Lepr db/db (leptin receptor-deficient) female mice as a model of type 2 diabetes and heart failure with preserved ejection fraction and identified Hhipl1 (hedgehog interacting protein-like 1), which encodes for a decoy receptor for HH (hedgehog) ligands as a gene upregulated in the cardiac vascular fraction of diseased mice...
November 30, 2023: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38003291/dipeptidyl-peptidase-4-stimulation-induces-adipogenesis-related-gene-expression-of-adipose-stromal-cells
#5
JOURNAL ARTICLE
Hsiao-Chi Lai, Pei-Hsuan Chen, Chia-Hua Tang, Lee-Wei Chen
Adipogenesis has emerged as a new therapeutic target for regulating metabolism and achieving anti-inflammatory and anti-atherosclerotic effects via the release of adiponectin. However, at present, the effects and mechanism of action of dipeptidyl peptidase 4 (DPP4) stimulation on adiponectin production and adipogenesis have not been clarified. Here, we investigated the effects of DPP4 stimulation with monocyte chemoattractant protein-1 (MCP-1) on platelet-derived growth factor receptor alpha (PDGFRα) expression in adipose tissue and blood adiponectin levels...
November 8, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37850093/-in-vivo-retinal-imaging-is-associated-with-cognitive-decline-blood-brain-barrier-disruption-and-neuroinflammation-in-type-2-diabetic-mice
#6
JOURNAL ARTICLE
May Majimbi, Samuel McLenachan, Michael Nesbit, Fred K Chen, Virginie Lam, John Mamo, Ryu Takechi
INTRODUCTION: Type 2 diabetes (T2D) is associated with chronic inflammation and neurovascular changes that lead to functional impairment and atrophy in neural-derived tissue. A reduction in retinal thickness is an early indicator of diabetic retinopathy (DR), with progressive loss of neuroglia corresponding to DR severity. The brain undergoes similar pathophysiological events as the retina, which contribute to T2D-related cognitive decline. METHODS: This study explored the relationship between retinal thinning and cognitive decline in the LepR db/db model of T2D...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37731032/galantamine-improves-glycemic-control-and-diabetic-nephropathy-in-lepr-db-db-mice
#7
JOURNAL ARTICLE
Qinghe Meng, Julia Ma, Liye Suo, Napat Pruekprasert, Prithi Chakrapani, Robert N Cooney
Galantamine, a centrally acting acetylcholinesterase inhibitor, has been shown to attenuate inflammation and insulin resistance in patients with metabolic syndrome. We investigated the effects of galantamine on glycemic control and development of diabetic nephropathy (DN) in Leprdb/db mice. Galantamine significantly reduced food intake, body weight, blood glucose and HbA1c levels. Insulin resistance (HOMA-IR, QUICKI), HOMA-β and elevations in plasma inflammatory cytokine levels (TNF-α, IL-6 and HMGB-1) were all attenuated by galantamine...
September 20, 2023: Scientific Reports
https://read.qxmd.com/read/37719890/comparisons-of-the-effects-of-silk-elastin-and-collagen-sponges-on-wound-healing-in-murine-models
#8
JOURNAL ARTICLE
Eiichi Sawaragi, Hiroki Yamanaka, Yuanjiaozi Li, Tomo Unzai, Shingo Kawabata, Takashi Nakano, Yasuhiro Katayama, Michiharu Sakamoto, Yasuhiko Tabata, Naoki Morimoto
INTRODUCTIONS: Silk elastin, a recombinant protein with repeats of elastin and silk fibroin, possesses a self-gelling ability and is a potential wound dressing material. The aim of this study is to elucidate the mechanism of the wound healing-promoting effect of silk elastin by comparing its in vivo behavior in a mouse wound model with that of a collagen sponge. METHODS: Skin defects (8 mm in diameter) were created on the backs of C57BL/6J and BKS.Cg- + Lepr/+Lepr db male mice...
December 2023: Regenerative Therapy
https://read.qxmd.com/read/37500497/integrin-%C3%AE-5-subunit-regulates-hyperglycemia-induced-vascular-endothelial-cell-apoptosis-through-foxo1-mediated-macroautophagy
#9
JOURNAL ARTICLE
Xuze Lin, Sizhuang Huang, Side Gao, Jinxing Liu, Jiong Tang, Mengyue Yu
BACKGROUND: Hyperglycemia frequently induces apoptosis in endothelial cells and ultimately contributes to microvascular dysfunction in patients with diabetes mellitus (DM). Previous research reported that the expression of integrins as well as their ligands was elevated in the diseased vessels of DM patients. However, the association between integrins and hyperglycemia-induced cell death is still unclear. This research was designed to investigate the role played by integrin subunit β5 (ITGB5) in hyperglycemia-induced endothelial cell apoptosis...
July 27, 2023: Chinese Medical Journal
https://read.qxmd.com/read/36812665/opioid-growth-factor-receptor-anatomical-distribution-and-receptor-colocalization-in-neurons-of-the-adult-mouse-brain
#10
JOURNAL ARTICLE
Zainab Y Kareem, Patricia J McLaughlin, Rashmi Kumari
The opioid growth factor (OGF) is an endogenous peptide that binds to the nuclear-associated receptor (OGFr), and plays a significant role in the proliferation of developing, renewing, and healing tissues. The receptor is widely expressed in a variety of organs, however its distribution in the brain remains unknown. In this study, we investigated the distribution of OGFr in different brain regions of male heterozygous (-/+ Lepr db /J), non -diabetic mice and determined the localization of the receptor in three major brain cell types, astrocytes, microglia, and neurons...
February 15, 2023: Neuropeptides
https://read.qxmd.com/read/36798361/mechanisms-of-spinophilin-dependent-pancreas-dysregulation-underlying-diabesity
#11
Kaitlyn C Stickel, Amber L Mosley, Emma H Doud, Teri L Belecky-Adams, Anthony J Baucum
OBJECTIVE: Spinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino -/- ) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear. METHODS & RESULTS: We have corroborated and expanded upon previous studies to determine that Spino -/- mice have decreased weight gain and improved glucose tolerance in two different models of obesity...
February 8, 2023: bioRxiv
https://read.qxmd.com/read/36572735/gts-21-a-selective-alpha7-nicotinic-acetylcholine-receptor-agonist-ameliorates-diabetic-nephropathy-in-lepr-db-db-mice
#12
JOURNAL ARTICLE
Qinghe Meng, Xinghan Tian, Junwei Li, Napat Pruekprasert, Ravi Dhawan, George G Holz, Robert N Cooney
Diabetic nephropathy (DN) is a serious complicating factor in human type 2 diabetes mellitus (T2DM), and it commonly results in end-stage renal disease (ESRD) that requires kidney dialysis. Here, we report that the α7 nicotinic acetylcholine receptor (α7nAChR) agonist GTS-21 exerts a novel anti-inflammatory action to ameliorate DN, as studied using an inbred strain of Leprdb/db mice in which hyperglycemia and obesity co-exist owing to defective leptin receptor (Lepr) signaling. For this analysis, GTS-21 was administered to 10-12 week-old male and female mice as a 4 mg/kg intraperitoneal injection, twice-a-day, for 8 weeks...
December 26, 2022: Scientific Reports
https://read.qxmd.com/read/36453206/monocyte-chemoattractant-protein-1-supplemented-plasma-enhances-adiponectin-and-adipogenesis-related-gene-expression
#13
JOURNAL ARTICLE
Tzyy-Bin Tsay, Pei-Hsuan Chen, Merton Li, Chia-Hua Tang, Lee-Wei Chen
Increasing adipogenesis has been explored to treat metabolic diseases and atherosclerosis through the release of adiponectin. The effects and mechanism of platelet-rich plasma treatment on fat graft survival and adipogenesis have not been clarified. Here, we aimed to study the effects of monocyte chemoattractant protein-1 (MCP-1)-supplemented plasma on adipogenesis-related gene expression and adiponectin levels. Stromal vascular fractions (SVFs) purified from the inguinal adipose tissue of obese and diabetic (Leprdb/db) mice were treated with plasma from control (Lepr+/+) mice supplemented with 10 ng or 50 ng of MCP-1...
December 1, 2022: Stem Cells and Development
https://read.qxmd.com/read/36448444/praliciguat-promotes-ischemic-leg-reperfusion-on-leptin-receptor-deficient-mice
#14
JOURNAL ARTICLE
Ninon Foussard, Paul Rouault, Lauriane Cornuault, Annabel Reynaud, Emmanuel S Buys, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Kamel Mohammedi, Marie-Ange Renault
BACKGROUND: Lower-limb peripheral artery disease is one of the major complications of diabetes. Peripheral artery disease is associated with poor limb and cardiovascular prognoses, along with a dramatic decrease in life expectancy. Despite major medical advances in the treatment of diabetes, a substantial therapeutic gap remains in the peripheral artery disease population. Praliciguat is an orally available sGC (soluble guanylate cyclase) stimulator that has been reported both preclinically and in early stage clinical trials to have favorable effects in metabolic and hemodynamic outcomes, suggesting that it may have a potential beneficial effect in peripheral artery disease...
November 30, 2022: Circulation Research
https://read.qxmd.com/read/36423694/small-extracellular-vesicle-targeting-of-hypothalamic-ampk%C3%AE-1-promotes-weight-loss-in-leptin-receptor-deficient-mice
#15
JOURNAL ARTICLE
Edward Milbank, Nathalia Dragano, Xavi Vidal-Gómez, Verónica Rivas-Limeres, Pablo Garrido-Gil, Mireille Wertheimer, Sylvain Recoquillon, María P Pata, José Luis Labandeira-Garcia, Carlos Diéguez, Rubén Nogueiras, M Carmen Martínez, Ramaroson Andriantsitohaina, Miguel López
BACKGROUND AND AIMS: Leptin receptor (LEPR) deficiency promotes severe obesity and metabolic disorders. However, the current therapeutic options against this syndrome are scarce. METHODS: db/db mice and their wildtypes were systemically treated with neuronal-targeted small extracellular vesicles (sEVs) harboring a plasmid encoding a dominant negative mutant of AMP-activated protein kinase alpha 1 (AMPKα1-DN) driven by steroidogenic factor 1 (SF1) promoter; this approach allowed to modulate AMPK activity, specifically in SF1 cells of the ventromedial nucleus of the hypothalamus (VMH)...
February 2023: Metabolism: Clinical and Experimental
https://read.qxmd.com/read/36122436/magnolol-effectively-ameliorates-diabetic-peripheral-neuropathy-in-mice
#16
JOURNAL ARTICLE
Juanzhen Yang, Yuxi Wei, Tong Zhao, Xiaoqian Li, Xuejian Zhao, Xingnan Ouyang, Lihua Zhou, Xiuqin Zhan, Minyi Qian, Jiaying Wang, Xu Shen
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes lacking efficient treatment. Magnolol (MG), a peroxisome proliferator-activated receptor γ (PPARγ) agonist, is a natural product derived from Magnolia officinalis and widely used to treat a variety of diseases as a traditional Chinese medicine and Japanese Kampo medicine. PURPOSE: Here, we aimed to investigate the potential of MG in ameliorating DPN-like pathology in mice and decipher the mechanism of MG in treating DPN...
September 5, 2022: Phytomedicine
https://read.qxmd.com/read/35883204/adipose-derived-stromal-cells-reverse-insulin-resistance-through-inhibition-of-m1-expression-in-a-type-2-diabetes-mellitus-mouse-model
#17
JOURNAL ARTICLE
Lee-Wei Chen, Pei-Hsuan Chen, Chia-Hua Tang, Jui-Hung Yen
BACKGROUND: Adipose tissue inflammation is considered as one of the major mechanisms underlying the pathogenesis of insulin resistance and complications in diabetes. Here, we aimed to study the effects of adipose-derived stromal cells on diabetes-induced insulin resistance and M1 cytokine expression. METHODS: Stromal vascular fractions (SVFs) purified from the inguinal adipose tissue of diabetic mice were treated with plasma from either nondiabetic (Lepr+/+ ) or diabetic (Leprdb/db ) mice and injected into the inguinal white adipose tissue of Leprdb/db mice...
July 26, 2022: Stem Cell Research & Therapy
https://read.qxmd.com/read/35725532/verification-of-the-folkloric-and-anecdotal-antidiabetic-effects-of-hypoxis-hemerocallidea-fisch-c-a-mey-av%C3%A3-lall-and-isolated-%C3%AE-sitosterol-using-early-stage-type-ii-spontaneous-diabetic-mutant-bks-lepr-db-mice
#18
JOURNAL ARTICLE
N M Mkolo, O O Olaokun, P H King, I Janse van Rensburg, J N Eloff, V Naidoo
BACKGROUND: Previous studies in our laboratory in ex vivo assays have demonstrated H. hemerocallidea extract as potential antidiabetic agent through increased insulin release from pancreatic beta cells. Thus, for this study the early stage type II spontaneous diabetic mutant mice model was used to evaluate and determine the degree of the antidiabetic efficacy of H. hemerocallidea. METHODS: Eight-weeks-old type II spontaneous pre-diabetic mutant BKS-Leprdb mice were fed with feed supplemented with either H...
June 20, 2022: BMC complementary medicine and therapies
https://read.qxmd.com/read/35711339/alternate-day-fasting-improves-endothelial-function-in-type-2-diabetic-mice-role-of-adipose-derived-hormones
#19
JOURNAL ARTICLE
Jian Cui, Sewon Lee, Yan Sun, Cuihua Zhang, Michael A Hill, Yuhang Li, Hanrui Zhang
Introduction: Intermittent fasting, including alternate day fasting (ADF), has grown in popularity as it can produce clinically significant metabolic benefits and is often considered to be easier to adhere to than other types of diets such as chronic calorie restriction. However, the effects of ADF on diabetes-associated vascular dysfunction, and the role of adipose-derived hormones, i.e., adipokines, in mediating its effects, remain largely unknown. Objective: We aimed to test the hypothesis that ADF protects against diabetes-associated endothelial dysfunction, at least partly through modulating adipokine profiles...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/35310970/proteomic-analysis-suggests-altered-mitochondrial-metabolic-profile-associated-with-diabetic-cardiomyopathy
#20
JOURNAL ARTICLE
Karina P Gomes, Anshul S Jadli, Luiz G N de Almeida, Noura N Ballasy, Pariya Edalat, Ruchita Shandilya, Daniel Young, Darrell Belke, Jane Shearer, Antoine Dufour, Vaibhav B Patel
Diabetic cardiomyopathy (DbCM) occurs independently of cardiovascular diseases or hypertension, leading to heart failure and increased risk for death in diabetic patients. To investigate the molecular mechanisms involved in DbCM, we performed a quantitative proteomic profiling analysis in the left ventricle (LV) of type 2 diabetic mice. Six-month-old C57BL/6J-lepr/lepr ( db/db ) mice exhibited DbCM associated with diastolic dysfunction and cardiac hypertrophy. Using quantitative shotgun proteomic analysis, we identified 53 differentially expressed proteins in the LVs of db/db mice, majorly associated with the regulation of energy metabolism...
2022: Frontiers in Cardiovascular Medicine
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