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Blood lipid ratio

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https://www.readbyqxmd.com/read/29148894/metabolic-profile-in-patients-with-mild-obstructive-sleep-apnea
#1
Luciana Oliveira E Silva, Thais M Guimarães, Gabriela P Luz, Glaury Coelho, Luciana Badke, Ildonete R Almeida, Aline Millani-Carneiro, Sergio Tufik, Lia Bittencourt, Sonia M Togeiro
BACKGROUND: Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults. However, it is not clear whether mild OSA has significant metabolic complications. This study examined the prevalence of metabolic syndrome (MS) in patients with mild OSA compared to control group. METHODS: Adults (18-65 years of age) of both genders with a body mass index (BMI) ≤35 kg/m(2) were included. The mild OSA group comprised of patients with an apnea-hypopnea index (AHI) score of ≥5 but ≤15 events/hr of sleep, independent of other symptoms...
November 17, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29145552/association-between-perceived-barriers-to-diabetes-self-management-and-diabetic-retinopathy-in-asian-patients-with-type-2-diabetes
#2
Ryan Eyn Kidd Man, Eva K Fenwick, Alfred Tau Liang Gan, Charumathi Sabanayagam, Preeti Gupta, Amudha Aravindhan, Tien Yin Wong, Gavin Siew Wei Tan, Ecosse L Lamoureux
Importance: A patient's perceived barriers to diabetes self-management (DSM) may affect his or her risk of diabetic retinopathy (DR); however, few studies have examined this association. Objective: To examine the association between perceived barriers to DSM and the severity spectrum of DR in Asian patients with type 2 diabetes. Design, Setting, and Participants: A cross-sectional clinic-based study, the Singapore Diabetes Management Project, was conducted from December 28, 2010, to March 20, 2013, at the Singapore National Eye Centre, a tertiary eye care institute...
November 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29144802/lipid-accumulation-product-visceral-adiposity-index-and-chinese-visceral-adiposity-index-as-markers-of-cardiometabolic-risk-in-adult-growth-hormone-deficiency-patients-a-cross-sectional-study
#3
Xin Xie, Qing Li, Lingmin Zhang, Wei Ren
OBJECTIVE: Adult growth hormone deficiency (AGHD) is associated with cardiometabolic risk factors. Given that cardiovascular disease (CVD) is an important cause of morbidity and mortality in the AGHD population, there is a need for alternative, non-invasive methods of assessing cardiometabolic risk in this population. Chinese visceral adiposity index (CVAI) is a new marker of visceral fat dysfunction that is based on age, body mass index (BMI), waist circumference (WC) and metabolic parameters...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29142415/are-polyunsaturated-fatty-acid-metabolites-the-protective-effect-of-4-hydroxytyrosol-on-human-red-blood-cell-membranes-and-oxidative-damage-4-hydroxyalkenals-compatible-in-hypertriglyceridemic-patients
#4
Giuseppe Gallo, Rosalinda Bruno, Adele Taranto, Guglielmo Martino
Background: Increased levels of malondialdehyde (MDA) and 4-hydroxynonenal (HNE) are demonstrated in plasma of uremic patients. A study showed that the comparison of erythrocytes of healthy and diseased patients (obese, hypertensive, and Type 2 diabetics) with age is associated to a disturbed oxidant/antioxidant balance when obesity is associated with hypertension. 4-hydroxytyrosol is shown to significantly protect red blood cells (RBCs) from oxidative damage (4-HNE). In literature, there are partial discussions on the role of lipids and their oxidation products...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29130563/serum-lipoprotein-and-rbc-rigidity-index-to-predict-cerebral-infarction-in-patients-with-carotid-artery-stenosis
#5
Zhiwu Dong, Qiang Guo, Li Sun, Feifei Li, Aihong Zhao, Jingfan Liu, Peipei Qu, Qinghua Zhu, Chunhai Xiao, Fusheng Niu, Shuang Liang
OBJECTIVE: This study aims to determine the risk factors and to predict the occurrence of cerebral infarction in patients with carotid artery stenosis. METHODS: Two hundred and one subjects with carotid artery stenosis were retrospectively selected from Jinshan Branch of Shanghai Sixth People's Hospital, 115 cases of which with cerebral infarction and 86 without it. Clinical tests were performed including coagulation indices, fasting glucose, serum lipid, and blood rheology...
November 11, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29128339/rs6923761-gene-variant-in-glucagon-like-peptide-1-receptor-allelic-frequencies-and-influence-on-cardiovascular-risk-factors-in-a-multicenter-study-of-castilla-leon
#6
D A de Luis, M Ballesteros, A Lopez Guzman, E Ruiz, C Muñoz, M A Penacho, P Iglesias, A Maldonado, V Puigdevall, M Delgado
BACKGROUND: Some GLP-1 receptor studies have identified polymorphisms in the GLP-1 receptor gene that might be related to different cardiovascular risk factors. OBJECTIVE: Our aim was to investigate the allelic distribution of rs6923761 GLP-1 receptor polymorphism in a geographic area of Spain (Community of Castilla y Leon) and to evaluate the influence of this polymorphism on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese patients...
November 2, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29127028/effects-of-dietary-panax-notoginseng-extract-on-growth-performance-fish-composition-immune-responses-intestinal-histology-and-immune-related-genes-expression-of-hybrid-grouper-epinephelus-lanceolatus-%C3%A2-%C3%A3-epinephelus-fuscoguttatus-%C3%A2-fed-high-lipid-diets
#7
Zhenzhu Sun, Xiaohong Tan, Huaqun Ye, Cuiyun Zou, Chaoxia Ye, Anli Wang
Growth, plasma biochemical parameters, fish composition, immune parameters, intestinal histology, and expressions of immune-related genes were examined in hybrid grouper (Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀) that fed respectively six diets containing Panax notoginseng extract (PNE) at 0, 0.5, 1, 2, 4, and 10 g kg(-1) after 8 weeks. Results indicated that dietary PNE significantly improved growth, feed efficiency ratio, protein efficiency ratio, and protein deposit rate, and significantly increased crude protein and crude lipid levels of whole body and crude protein level of muscle...
November 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29123394/quercetin-nanoparticle-complex-attenuated-diabetic-nephropathy-via-regulating-the-expression-level-of-icam-1-on-endothelium
#8
Fei Tong, Suhuan Liu, Bing Yan, Xuejun Li, Shiwei Ruan, Shuyu Yang
The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE. QUE 10 mg/kg as a single abdominal subcutaneous injection daily for 8 weeks continuously in diabetic rats and 10 mg/kg QUE nanoparticle complex as a single abdominal subcutaneous injection every 5 days, continuously administered for 8 weeks to diabetic rats. Blood and left kidneys were collected; pathological change of kidney, renal function, oxidative stress level, blood glucose level, serum lipid, urine protein, and albumin/creatinine ratio were measured; and neutrophil adhesion, ICAM-1 expression, and CD11b(+) cells infiltration were observed...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29117621/gender-differences-in-cardiometabolic-risk-factors-in-metabolically-healthy-normal-weight-adults-with-central-obesity
#9
Katarína Šebeková, Melinda Csongová, Radana Gurecká, Zora Krivošíková, Jozef Šebek
We investigated whether metabolically healthy normal weight adults with central obesity display worse cardiometabolic profile compared with their centrally lean counterparts. This retrospective, cross-sectional study, comprised 1 135 subjects (64% females) aged 18-to-81 years, presenting ≤2 components of metabolic syndrome. They were classified as centrally lean (waist-to-height ratio (WHtR)<0.5 and waist circumference<80 cm in females and<94 cm in males) or presenting central obesity (WHtR ≥0...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29111915/effects-of-egg-consumption-on-blood-lipids-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#10
Mohammad Hossein Rouhani, Nafiseh Rashidi-Pourfard, Amin Salehi-Abargouei, Majid Karimi, Fahimeh Haghighatdoost
BACKGROUND: It is widely agreed that egg consumption only modestly influences serum lipid concentrations. However, there is no meta-analysis summarizing existing randomized controlled trials. OBJECTIVE: The purpose of this study was to conduct a meta-analysis of published randomized controlled trials to explore the quantitative effect of egg consumption on serum lipid concentrations. DESIGN: Online databases including MEDLINE, Proquest and Google Scholar were systematically searched...
November 7, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29107454/prevalence-of-micro-and-macrovascular-diabetes-complications-at-time-of-type-2-diabetes-diagnosis-and-associated-clinical-characteristics-a-cross-sectional-baseline-study-of-6958-patients-in-the-danish-dd2-cohort
#11
Anne Gedebjerg, Thomas Peter Almdal, Klara Berencsi, Jørgen Rungby, Jens Steen Nielsen, Daniel R Witte, Søren Friborg, Ivan Brandslund, Allan Vaag, Henning Beck-Nielsen, Henrik Toft Sørensen, Reimar Wernich Thomsen
AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis. METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression...
September 19, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29105313/immunological-changes-induced-in-peach-allergy-patients-with-systemic-reactions-by-pru-p-3-sublingual-immunotherapy
#12
Francisca Palomares, Francisca Gomez, Gador Bogas, Campo Paloma, James Richard Perkins, A Diaz-Perales, Maria José Rodriguez, Ana Prieto, Domingo Barber, María José Torres, Cristobalina Mayorga
SCOPE: Sublingual immunotherapy using peach extract enriched in Pru p 3 (Pru p 3-enriched-SLIT) brings a new perspective to treating patients with allergy to lipid transfer proteins. We evaluated the immunological changes induced by Pru p 3-enriched-SLIT during one year. METHODS AND RESULTS: Three groups were included: peach allergic patients who received Pru p 3-enriched-SLIT, peach allergic untreated patients and controls. Peripheral blood mononuclear cells were obtained before treatment and different time-points...
November 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29104344/validation-of-a-machine-learning-approach-for-venous-thromboembolism-risk-prediction-in-oncology
#13
Patrizia Ferroni, Fabio M Zanzotto, Noemi Scarpato, Silvia Riondino, Fiorella Guadagni, Mario Roselli
Using kernel machine learning (ML) and random optimization (RO) techniques, we recently developed a set of venous thromboembolism (VTE) risk predictors, which could be useful to devise a web interface for VTE risk stratification in chemotherapy-treated cancer patients. This study was designed to validate a model incorporating the two best predictors and to compare their combined performance with that of the currently recommended Khorana score (KS). Age, sex, tumor site/stage, hematological attributes, blood lipids, glycemic indexes, liver and kidney function, BMI, performance status, and supportive and anticancer drugs of 608 cancer outpatients were all entered in the model, with numerical attributes analyzed as continuous values...
2017: Disease Markers
https://www.readbyqxmd.com/read/29101421/long-term-follow-up-of-intensive-glycaemic-control-on-renal-outcomes-in-the-veterans-affairs-diabetes-trial-vadt
#14
Lily Agrawal, Nasrin Azad, Gideon D Bahn, Ling Ge, Peter D Reaven, Rodney A Hayward, Domenic J Reda, Nicholas V Emanuele
AIMS/HYPOTHESIS: We conducted an analysis of data collected during the Veterans Affairs Diabetes Trial (VADT) and the follow-up study (VADT-F) to determine whether intensive (INT) compared with standard (STD) glycaemic control during the VADT resulted in better long-term kidney outcomes. METHODS: VADT randomly assigned 1791 veterans from 20 Veterans Affairs (VA) medical centres who had type 2 diabetes mellitus and a mean HbA1c of 9.4 ± 2% (79.2 mmol/mol) at baseline to receive either INT or STD glucose control for a median of 5...
November 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/29098543/effect-of-chromium-nanoparticles-on-physiological-stress-induced-by-exogenous-dexamethasone-in-japanese-quails
#15
Atefeh Berenjian, Seyed Davood Sharifi, Abdollah Mohammadi-Sangcheshmeh, Shekofeh Ghazanfari
Chromium (Cr), as an essential trace element, plays a critical role in carbohydrate, protein, and lipid metabolism in animals. It has been suggested that the beneficial effects of Cr increase by environmental stresses, which lead to greater Cr effects on stressed animals. The objective of the present study was to evaluate the response of physiologically stressed Japanese quails (Coturnix japonica) to dietary chromium nanoparticle (Nano-Cr) supplementation. The stress was induced by adding dexamethasone (0.6 mg/kg BW) to Japanese quails' diet from 17 to 22 days of age...
November 2, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29096829/ldl-apheresis-improves-coronary-flow-reserve-on-the-left-anterior-descending-artery-in-patients-with-familial-hypercholesterolemia-and-chronic-ischemic-heart-disease
#16
Tiziana Sampietro, Francesco Sbrana, Emilio Maria Pasanisi, Federico Bigazzi, Christina Petersen, Michele Coceani, Beatrice Dal Pino, Andrea Ripoli, Mascia Pianelli, Roberta Luciani
BACKGROUND: LDL apheresis (LA) influences the microcirculation, endothelial function and cardiovascular homeostasis. The aim of our study was to analyze temporal variations of coronary flow reserve (CFR) on the left anterior descending artery, obtained during dipyridamole stress echocardiography (DSE), in patients with severe familial hypercholesterolemia on LA (LA group) or not (not LA group) and ischemic heart disease (IHD). METHODS: The LA group consisted in 10 patients (mean age 65 ± 7 years, male 70%) with Familial Hypercholesterolemia and chronic IHD on maximally tolerated lipid lowering therapy and chronic LA treatment (median 7 years, interquartile range 6-14 years)...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29094355/th1-th2-immune-responses-and-oxidative-stress-in-caprine-flea-allergy-dermatitis
#17
Y Ajith, Umesh Dimri, A Gopalakrishnan, E Madhesh, Ricky Jhambh, Vivek Joshi, Devi Gopinath
Flea allergy dermatitis (FAD) is the common, often neglected skin disease of goats caused mainly by Ctenocephalides felis. The present study aimed to evaluate the immuno-oxidative pathobiology of FAD in goats. Twelve goats from the same herd were divided into two groups of six animals each. The group I (FAD) included animals with natural flea infestation and severe dermatitis lesions. The group II (Healthy control) animals were free from any parasitic infestation. To assess the pathological changes, the markers of oxidative stress (lipid peroxidation, reduced glutathione and total antioxidant capacity), and immune status (Tumour necrosis factor alpha, Interleukin 10, Transforming growth factor beta 1 and Th1/Th2 cytokine ratio) were evaluated from the blood and the serum samples...
November 2, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/29090223/paraoxonase-1-activity-lipid-profile-and-atherogenic-indexes-status-in-coronary-heart-disease
#18
Mostafa Cheraghi, Gholamreza Shahsavari, Ali Maleki, Hassan Ahmadvand
BACKGROUND: Dyslipidemia is considered an independent risk factor for coronary heart disease (CHD). In the present study, we examined lipid profiles and paraoxonase 1 (PON1) activity and atherogenic indexes status and the relationship of PON1 activity by high-density lipoprotein (HDL) and atherogenic indexes in CHD patients and healthy people. METHODS: The aim of the study was to compare PON1, lipid profiles, and atherogenic indexes in CHD patients and healthy people as controls...
October 2017: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29089804/the-framingham-risk-score-underestimates-the-risk-of-cardiovascular-events-in-the-her2-positive-breast-cancer-population
#19
W Law, C Johnson, M Rushton, S Dent
INTRODUCTION: Patients with breast cancer (bca) who overexpress her2 (the human epidermal growth factor receptor 2) are at risk for cardiotoxicity when treated with anthracycline-based chemotherapy and her2-targeted agents. The Framingham risk score (frs) is a validated tool that stratifies patients into high-, intermediate-, or low-risk groups and calculates their 10-year risk of developing cardiovascular disease (cvd) based on past medical history, systolic blood pressure, and measurement of serum lipids...
October 2017: Current Oncology
https://www.readbyqxmd.com/read/29089365/cardiometabolic-healthy-and-unhealthy-obesity-does-vitamin-d-play-a-role
#20
Eliana Piantanida, Daniela Gallo, Giovanni Veronesi, Eugenia Dozio, Eugenia Trotti, Adriana Lai, Silvia Ippolito, Jessica Sabatino, Maria Laura Tanda, Antonio Toniolo, Marco Ferrario, Luigi Bartalena
The aim of this observational study was to clarify the link between vitamin D status and metabolic syndrome (MetS) in people with visceral obesity. Design and methods One-hundred-ninety-six consecutive patients (152 women; mean age 51±13 years) with visceral obesity [mean body weight 103±20 Kg, mean waist circumference (WC) 119±13 cm] were enrolled at the Obesity Outpatient Clinic of the University of Insubria in Varese. Anthropometric measurements were recorded. Laboratory tests, including vitamin D [25(OH)D)], fasting blood glucose (FBG), lipid profile, liver and kidney function tests were assessed...
October 31, 2017: Endocrine Connections
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