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Lipid ratio

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https://www.readbyqxmd.com/read/29161504/solvent-and-temperature-effects-on-free-radical-formation-in-electronic-cigarette-aerosols
#1
Zachary T Bitzer, Reema Goel, Samantha M Reilly, Jonathan Foulds, Joshua Muscat, Ryan J Elias, John P Richie
The ever-evolving market of electronic cigarettes (e-cigarettes) presents a challenge for analyzing and characterizing the harmful products they can produce. Earlier we reported that e-cigarette aerosols can deliver high levels of reactive free radicals; however, there is little data characterizing the production of these potentially harmful oxidants. Thus, we have performed a detailed analysis of the different parameters affecting free radical production from e-cigarettes. Using a temperature controlled e-cigarette device and novel mechanism for reliably simulating e-cigarette usage conditions including coil activation and puff flow, we analyzed the effects of temperature, wattage, and e-liquid solvent composition of propylene glycol (PG) and glycerol (GLY) on radical production...
November 21, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29160443/body-fat-redistribution-and-changes-in-lipid-and-glucose-metabolism-in-people-living-with-hiv-aids
#2
Rebeca Antunes Beraldo, André Pereira Dos Santos, Mariana Palma Guimarães, Helena Siqueira Vassimon, Francisco José Albuquerque de Paula, Dalmo Roberto Lopes Machado, Maria Cristina Foss-Freitas, Anderson Marliere Navarro
INTRODUCTION: The HIV lipodystrophy syndrome is characterized by changes in metabolism, and body composition that increase cardiovascular risk of people living with HIV/AIDS (PLWHA) using highly active antiretroviral therapy (HAART). OBJECTIVE: To assess the prevalence of lipodystrophy and changes in lipid and glucose metabolism in PLWHA in use of HAART. METHODS: For the anthropometric evaluation we measured weight, height and abdominal circumference (AC)...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29160078/formation-of-lipid-bilayer-nanodiscs-by-diisobutylene-maleic-acid-dibma-copolymer
#3
Abraham Olusegun Oluwole, Johannes Klingler, Bartholomäus Danielczak, Jonathan Oyebamiji Babalola, Carolyn Vargas, Georg Pabst, Sandro Keller
Membrane proteins usually need to be extracted from their native environment and separated from other membrane components for in-depth in vitro characterization. The use of styrene/maleic acid (SMA) copolymers to solubilize membrane proteins and their surrounding lipids into bilayer nanodiscs is an attractive approach toward this goal. We have recently shown that diisobutylene/maleic acid (DIBMA) copolymer similarly solubilizes model and cellular membranes but, unlike SMA(3:1), has a mild impact on lipid acyl-chain order and thermotropic phase behavior...
November 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29159965/improvement-in-lipids-after-switch-to-boosted-atazanavir-or-darunavir-in-children-adolescents-with-perinatally-acquired-hiv-on-older-protease-inhibitors-results-from-the-pediatric-hiv-aids-cohort-study
#4
J Jao, W Yu, K Patel, T L Miller, B Karalius, M E Geffner, L A DiMeglio, A Mirza, J S Chen, M Silio, E J McFarland, R B Van Dyke, D Jacobson
OBJECTIVES: Dyslipidaemia is common in perinatally HIV-infected (PHIV) youth receiving protease inhibitors (PIs). Few studies have evaluated longitudinal lipid changes in PHIV youth after switch to newer PIs. METHODS: We compared longitudinal changes in fasting lipids [total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and TC:HDL-C ratio] in PHIV youth enrolled in the Pediatric HIV/AIDS Cohort Study (PHACS) Adolescent Master Protocol (AMP) study who switched to atazanavir/ritonavir (ATV/r)- or darunavir/ritonavir (DRV/r)-based antiretroviral therapy (ART) from an older PI-based ART and those remaining on an older PI...
November 21, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29159554/detailed-description-of-change-in-serum-cholesterol-profile-with-incremental-weight-loss-after-restrictive-bariatric-surgery
#5
Geraldine J Ooi, Arul Earnest, Lisa Doyle, Cheryl Laurie, John M Wentworth, Ken Sikaris, Carel W le Roux, Paul R Burton, Paul E O'Brien, Wendy A Brown
INTRODUCTION: Dyslipidemia affects up to 75% of morbidly obese individuals and is a key driver of cardiovascular disease. Weight loss is an established strategy to improve metabolic risk, including dyslipidemia. We aimed to determine weight loss goals for resolution of serum lipid abnormalities, by measuring improvements during progressive weight loss in obese individuals. METHODS: We performed a prospective cohort study of obese individuals with the metabolic syndrome undergoing adjustable gastric banding...
November 21, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29158633/comprehensive-physiological-analyses-and-reactive-oxygen-species-profiling-in-drought-tolerant-rice-genotypes-under-salinity-stress
#6
Sahana Basu, Ranjan Kumar Giri, Ibtesham Benazir, Santosh Kumar, Ravi Rajwanshi, Sharad Kumar Dwivedi, Gautam Kumar
Rice being a staple cereal is extremely susceptible towards abiotic stresses. Drought and salinity are two vital factors limiting rice cultivation in Eastern Indo-Gangetic Plains (EIGP). Present study has intended to evaluate the consequences of salinity stress on selected drought tolerant rice genotypes at the most susceptible seedling stage with an aim to identify the potential multi-stress (drought and salt) tolerant rice genotype of this region. Genotypic variation was obvious in all traits related to drought and salt susceptibility...
October 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29157913/evaluation-of-optimum-conditions-for-achyranthes-bidentata-polysaccharides-encapsulated-in-cubosomes-and-immunological-activity-in-vitro
#7
Ning Ou, Yaqing Sun, Shuzhen Zhou, Pengfei Gu, Zhengguang Liu, Ruonan Bo, Yuanlaing Hu, Jiaguo Liu, Deyun Wang
Cubosomes, as biocompatible carriers in drug delivery systems, consist of curved bicontinuous lipid bilayers. With a honeycombed structure divided into two internal aqueous channels, cubosomes could be used for many bioactive ingredients. Achyranthes bidentata polysaccharides (ABPs) are isolated from the roots of Achyranthes bidentata, used in Chinese herbal medicine, and present a noticeable effect as an immunomodulator. This study investigates the optimal preparation of combined cubosome-ABP (Cub-ABP) nanoparticles using response surface methodology and explores their characteristics and stability...
November 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29157655/roles-of-high-apolipoprotein-e-blood-levels-and-hdl-in-development-of-familial-dysbetalipoproteinemia-in-%C3%AE%C2%B52%C3%AE%C2%B52-subjects
#8
James P Corsetti, Charles E Sparks, Stephan J L Bakker, Eke G Gruppen, Robin P F Dullaart
OBJECTIVE: Familial dysbetalipoproteinemia (FD) or Type III hyperlipoproteinemia is a mixed hyperlipidemia closely associated with the ε2ε2 genotype of the common APOE polymorphism although not all homozygotes progress to FD. Unlike the polymorphism, few studies explore effects of apolipoprotein E (apoE) blood levels on FD development. Likewise, despite the known apoE2 lipoprotein binding preference for high-density lipoprotein (HDL); little work exists exploring HDL in FD. Accordingly, this study was undertaken to investigate potential roles in FD development for apoE and HDL...
November 17, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29157582/serum-lipid-profile-sleep-disordered-breathing-and-blood-pressure-in-the-elderly-a-10-year-follow-up-of-the-proof-synapse-cohort
#9
Denis Monneret, Jean-Claude Barthélémy, David Hupin, Delphine Maudoux, Sébastien Celle, Emilia Sforza, Frédéric Roche
OBJECTIVES: Dyslipidemia, sleep-disordered breathing (SDB) and hypertension are comorbid factors evidenced in adults, but poorly studied in old people. This study aimed to examine the long-term evolution of the serum lipid profile, and its relationships with SDB and blood pressure (BP) in the elderly. METHODS: A ten-year follow-up of the prospective Prognostic Indicator of Cardiovascular and Cerebrovascular Events (PROOF) and the Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea (SYNAPSE) cohort, which initially included 1011 elderly subjects from the general population, and who were untreated by continuous positive airway pressure (CPAP)...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29157043/association-of-first-trimester-maternal-lipid-profiles-and-triglyceride-glucose-index-with-the-risk-of-gestational-diabetes-mellitus-and-large-for-gestational-age-newborn
#10
Azar Pazhohan, Monireh Rezaee Moradali, Nahideh Pazhohan
OBJECTIVE: To evaluate the association of maternal first-trimester plasma lipid profiles, fasting plasma glucose (FPG), and triglyceride (TyG) index with the risk of gestational diabetes mellitus (GDM) and large for gestational age (LGA) infant in Iranian mothers. METHODS: Nine hundred and fifty-four healthy pregnant women were prospectively followed till after delivery. Maternal fasting lipids and glucose concentration were measured at nine-week gestation on average...
November 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29156768/clinical-significance-of-pre-surgical-serum-lipid-levels-in-patients-with-glioblastoma
#11
Ruofei Liang, Junhong Li, Mao Li, Yuan Yang, Xiang Wang, Qing Mao, Yanhui Liu
Accumulating evidence demonstrates that pre-surgical serum lipid levels are linked to the clinical outcome of different types of human malignant tumors, but few studies have explored the prognostic value of these easily accessible parameters in glioblastoma. The aim of the current study was to validate the association between pre-surgical serum lipid levels and the clinical outcome of patients with glioblastoma. The pre-surgical serum lipid levels (triglycerides, total cholesterol, high-density lipoprotein [HDL] cholesterol, and low-density lipoprotein [LDL] cholesterol) of 125 patients with glioblastoma, who underwent surgery between January 2015 and May 2016, were retrospectively evaluated...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156720/novel-strategies-of-raman-imaging-for-brain-tumor-research
#12
Imiela Anna, Polis Bartosz, Polis Lech, Abramczyk Halina
Raman diagnostics and imaging have been shown to be an effective tool for the analysis and discrimination of human brain tumors from normal structures. Raman spectroscopic methods have potential to be applied in clinical practice as they allow for identification of tumor margins during surgery. In this study, we investigate medulloblastoma (grade IV WHO) (n= 5), low-grade astrocytoma (grades I-II WHO) (n =4), ependymoma (n=3) and metastatic brain tumors (n= 1) and the tissue from the negative margins used as normal controls...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156544/endogenous-sphingolipid-signaling-pathway-implicated-in-the-action-of-croton-membranaceus-on-the-prostate-gland-in-bph-patients
#13
George Awuku Asare, Yvonne Anang, Daniel K Afriyie, Brodrick Yeboah Amoah, Bernice Asiedu, Derek Doku, Hannah Serwah Ocansey, Nana Yaw Odei Danso, Prince Tekpor, Sarah Osam
Background: Croton membranaceus extract has apoptotic effects on BPH-1 cells. This study determined if the apoptotic effects were created through the ceramide pathway. Methods: The study was a follow-up to a previous observational study of 30 histologically confirmed patients with benign prostatic hyperplasia (BPH) who were on C. membranaceus ethanolic extract at 20 mg t.i.d orally for 3 mo. Thereafter, total and free prostate-specific antigen (PSA), lipid profile plus Apo lipoprotein A and B, ceramide/Sphingophospho-kinase 1 (SphK1) and 2 (SphK2), sphingosine lyase (SPL), the cytotoxic adducts of oxidative stress 4-hydroxy-2-nonenal (4HNE) and malondialdehyde (MDA), were determined...
November 18, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29156084/role-of-charge-and-hydrophobicity-in-liprotide-formation-a-molecular-dynamics-study-with-experimental-constraints
#14
Jannik Nedergaard Pedersen, Pim Wilhelmus Johannes Maria Frederix, Jan Skov Pedersen, Siewert Jan Marrink, Daniel Otzen
Bovine α-lactalbumin (aLA) and oleate (OA) form a complex that has been intensively studied for its tumoricidal activity. Small-angle X-ray scattering (SAXS) has revealed a lipid core surrounded by partially unfolded protein. We call this type of complex a liprotide. Little is known of the molecular interactions between OA and aLA and no technique has so far provided any high resolution structure of liprotides. Here, we used coarse grained (CG) molecular dynamics (MD) simulations, Isothermal titration calorimetry (ITC) and SAXS to investigate the interactions between aLA and OA during the process of liprotide formation...
November 20, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29155120/risk-of-type-2-diabetes-mellitus-associated-with-plasma-lipid-levels-the-rural-chinese-cohort-study
#15
Ming Zhang, Junmei Zhou, Yu Liu, Xizhuo Sun, Xinping Luo, Chengyi Han, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dongdong Zhang, Xuejiao Liu, Dongsheng Hu
AIM: To investigate the association of type 2 diabetes mellitus (T2DM) risk and plasma lipid levels in rural Chinese. METHODS: Each lipid variable was divided into quartiles and dichotomized by clinical cutoff points. Cox proportional-hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of T2DM risk and plasma lipid levels and explore the interaction between plasma lipid levels and other risk factors. RESULTS: 11,929 participants were included in the analysis...
November 15, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29154726/comparison-of-apolipoprotein-apob-apoa-1-and-lipoprotein-total-cholesterol-hdl-ratios-in-obese-adolescents
#16
Ramin Alemzadeh, Jessica Kichler
BACKGROUND: Serum (ApoB/ApoA-1) ratio is considered a stronger predictor of systemic inflammation and atherosclerosis than serum total cholesterol/HDL (TC/HDL) ratio among adults. We evaluated the relationships between ApoB/ApoA-1 and TC/HDL ratios with surrogate markers of inflammation and insulin resistance (IR) among obese adolescents. METHODS: Body mass index z-score (BMI-z), body composition, fasting glucose, insulin, lipids, high-sensitive c-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 143 obese adolescents...
November 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29153878/extensive-processing-of-sediment-pore-water-dissolved-organic-matter-during-anoxic-incubation-as-observed-by-high-field-mass-spectrometry-fticr-ms
#17
Juliana Valle, Michael Gonsior, Mourad Harir, Alex Enrich-Prast, Philippe Schmitt-Kopplin, David Bastviken, Ralf Conrad, Norbert Hertkorn
Dissolved organic matter (DOM) contained in lake sediments is a carbon source for many microbial degradation processes, including aerobic and anaerobic mineralization. During anaerobic degradation, DOM is partially consumed and transformed into new molecules while the greenhouse gases methane (CH4) and carbon dioxide (CO2) are produced. In this study, we used ultrahigh resolution mass spectrometry to trace differences in the composition of solid-phase extractable (PPL resin) pore water DOM (SPE-DOM) isolated from surface sediments of three boreal lakes before and after 40 days of anoxic incubation, with concomitant determination of CH4 and CO2 evolution...
November 7, 2017: Water Research
https://www.readbyqxmd.com/read/29152255/effects-of-monobutyrin-and-tributyrin-on-liver-lipid-profile-caecal-microbiota-composition-and-scfa-in-high-fat-diet-fed-rats
#18
Thao Duy Nguyen, Olena Prykhodko, Frida Fåk Hållenius, Margareta Nyman
Butyric acid has been shown to have suppressive effects on inflammation and diseases related to the intestinal tract. The aim of the present study was to investigate whether supplementation of two glycerol esters, monobutyrin (MB) and tributyrin (TB), would reach the hindgut of rats, thus having an effect on the caecal profile of SCFA, microbiota composition and some risk markers associated with chronic inflammation. For this purpose, rats were fed high-fat diets after adding MB (1 and 5 g/kg) and TB (5 g/kg) to a diet without any supplementation (high-fat control; HFC)...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29152152/association-of-genetic-variations-in-the-lipid-regulatory-pathway-genes-fbxw7-and-srebps-with-coronary-artery-disease-among-han-chinese-and-uygur-chinese-populations-in-xinjiang-china
#19
Asiya Abudesimu, Dilare Adi, Dilixiati Siti, Xiang Xie, Yi-Ning Yang, Xiao-Mei Li, Ying-Hong Wang, Yong-Tao Wang, Ya-Jie Meng, Fen Liu, Bang-Dang Chen, Xiang Ma, Zhen-Yan Fu, Yi-Tong Ma
Background: Hyperlipidemia is a major risk factor for coronary artery disease (CAD). The current study was designed to explore the possible correlation between single nucleotide polymorphisms (SNPs) in the lipid homeostasis regulatory genes F-box and WD repeat domain-containing 7 (FBXW7) and sterol regulatory element-binding proteins (SREBPs) with CAD among Han Chinese and Uygur Chinese populations in Xinjiang, China. Results: In the Uygur Chinese population, rs9902941 in SREBP-1 and rs10033601 in FBXW7 were found to be associated with CAD in a recessive model (TT vs...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151833/effect-of-ewe-s-semi-skimmed-and-whole-and-cow-s-milk-yogurt-consumption-on-the-lipid-profile-of-control-subjects-a-crossover-study
#20
Begoña Olmedilla-Alonso, Esther Nova-Rebato, Natalia García-González, Ana-Belén Martín-Diana, Javier Fontecha, David Delgado, Ana-Elisa Gredilla, Francisco Bueno, Carmen Asensio-Vegas
Yogurt is the most widely consumed fermented milk product worldwide. Studies have mainly used milk and dairy products from cow, which have a lower fat content than those from ewe and a different lipid profile. This study investigated the effect on the lipid profile of control subjects of three different set yogurts: (a) semi-skimmed ewe´s milk yogurt (2.8% milk fat); (b) whole ewe´s milk yogurt (5.8 % milk fat); (c) cow´s milk yogurt (3 % milk fat). A randomized crossover study included 30 healthy adults (16 women) to consume 250 g/yogurt/day during three consecutive 5-weeks periods separated by 4-week washouts...
2017: Food & Nutrition Research
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