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Lipid ratio

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https://www.readbyqxmd.com/read/28531282/near-infrared-spectroscopy-derived-lipid-core-burden-index-predicts-adverse-cardiovascular-outcome-in-patients-with-coronary-artery-disease-during-long-term-follow-up
#1
Anne-Sophie Schuurman, Maxime Vroegindewey, Isabella Kardys, Rohit M Oemrawsingh, Jin M Cheng, Sanneke de Boer, Hector M Garcia-Garcia, Robert-Jan van Geuns, Evelyn S Regar, Joost Daemen, Nicolas M van Mieghem, Patrick W Serruys, Eric Boersma, K Martijn Akkerhuis
Aims: Near-infrared spectroscopy (NIRS) is able to quantify cholesterol within coronary arteries by the lipid core burden index (LCBI). We studied the prognostic value of NIRS-derived LCBI in patients with coronary artery disease (CAD) for adverse cardiac outcome during long-term follow-up. Methods and results: During 2009-2013, NIRS was performed in a non-culprit artery of 275 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina...
May 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28531241/effect-of-statin-treatment-vs-usual-care-on-primary-cardiovascular-prevention-among-older-adults-the-allhat-llt-randomized-clinical-trial
#2
Benjamin H Han, David Sutin, Jeff D Williamson, Barry R Davis, Linda B Piller, Hannah Pervin, Sara L Pressel, Caroline S Blaum
Importance: While statin therapy for primary cardiovascular prevention has been associated with reductions in cardiovascular morbidity, the effect on all-cause mortality has been variable. There is little evidence to guide the use of statins for primary prevention in adults 75 years and older. Objectives: To examine statin treatment among adults aged 65 to 74 years and 75 years and older when used for primary prevention in the Lipid-Lowering Trial (LLT) component of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT)...
May 22, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28529126/l-a-ratio-insulin-resistance-and-metabolic-risk-in-women-with-polycystic-ovarian-syndrome
#3
Vandana Gupta, Supriya Mishra, Sameeksha Mishra, Vani Gupta
BACKGROUND AND AIMS: The plasma leptin-adiponectin ratio (L:A) has been suggested as a one of the potentially independent predictor of metabolic risk and Insulin resistance in women with polycystic ovarian syndrome (PCOS). METHODS: This is a case-control study, total 439 female subjects, comprises in to two group 223 cases (PCOS) and 216 control (non-PCOS women) according to their clinical characteristics. Further both case and control group were sub-grouped in PCOS and non-PCOS with metabolic syndrome (wMetS) and without metabolic syndrome (woMetS) as per National Cholesterol Education Program Treatment Panel (NCEPATP) guidelines...
May 10, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28529017/proatherogenic-lipid-profile-in-early-childhood-association-with-weight-status-at-4-years-and-parental-obesity
#4
Isolina Riaño-Galán, Ana Fernández-Somoano, Cristina Rodríguez-Dehli, Damaskini Valvi, Martine Vrijheid, Adonina Tardón
OBJECTIVES: To determine lipid profiles in early childhood and evaluate their association with weight status at 4 years of age. Additionally, we evaluated whether the risk of overweight or having an altered lipid profile was associated with parental weight status. STUDY DESIGN: Five hundred eighty two mothers and their 4-year-old children from 2 Spanish population-based cohorts were studied. Weight status in children at 4 years of age was classified as overweight or obese using the International Obesity Task Force criteria...
May 18, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28528591/conversion-ratios-of-n-3-fatty-acids-between-plasma-and-erythrocytes-a-systematic-review-and-meta-regression
#5
Xue Feng Hu, Simran K Sandhu, William S Harris, Hing Man Chan
As biomarkers of dietary intake or disease risk factor, n-3 fatty acid (FA) can be measured in plasma phospholipids (PL), total lipids (TL) or erythrocytes. However, the numeric relationships between n-3 FA in these lipid pools are not clear. Our goal was to derive conversion ratios for plasma and erythrocyte n-3 FA. Potential studies were identified through systematic literature search in PubMed, Embase and the Cochrane Library of Systematic reviews (1950 to October 2014). In all, fifty-six studies reporting n-3 in healthy individuals were included, of which thirty-four articles reported plasma PL and erythrocytes, and twenty-two reported plasma TL and erythrocytes...
May 22, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28526981/rubisco-mutants-of-chlamydomonas-reinhardtii-display-divergent-photosynthetic-parameters-and-lipid-allocation
#6
M G Esquível, A R Matos, J Marques Silva
Photosynthesis and lipid allocation were investigated in Rubisco small subunit mutants of the microalga Chlamydomonas reinhardtii. Comparative analyses were undertaken with cells grown photoheterotrophically under sulphur-replete or sulphur-depleted conditions. The Y67A Rubisco mutant, which has previously demonstrated a pronounced reduction in Rubisco levels and higher hydrogen production rates than the wild type, also shows the following divergences in photosynthetic phenotype and lipid allocation: (i) low Fv/Fm (maximum photochemical efficiency), (ii) low effective quantum yield of photosystem II (ΦPSII), (iii) low effectiveness at protection against high light intensities, (iv) a higher level of total lipids per pigment and (v) changes in the relative proportions of different fatty acids, with a marked decrease in unsaturated fatty acids (FAs)...
May 19, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28526388/serum-vitamin-d-and-change-in-lipid-levels-over-5%C3%A2-y-the-atherosclerosis-risk-in-communities-study
#7
Kamil F Faridi, Di Zhao, Seth S Martin, Joshua R Lupton, Steven R Jones, Eliseo Guallar, Christie M Ballantyne, Pamela L Lutsey, Erin D Michos
OBJECTIVES: Deficiency of 25-hydroxyvitamin D (25[OH]D) is associated with increased risk for cardiovascular disease, perhaps mediated through dyslipidemia. Deficient 25(OH)D is cross-sectionally associated with dyslipidemia, but little is known about longitudinal lipid changes. The aim of this study was to determine the relationship of 25(OH)D deficiency to longitudinal lipid changes and risk for incident dyslipidemia. METHODS: This was a longitudinal community-based study of 13 039 participants from the ARIC (Atherosclerosis Risk in Communities) study who had 25(OH)D and lipids measured at baseline (1990-1992) and lipids remeasured in 1993 to 1994 and 1996 to 1998...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526377/orange-juice-allied-to-a-reduced-calorie-diet-results-in-weight-loss-and-ameliorates-obesity-related-biomarkers-a-randomized-controlled-trial
#8
Carolina Ribeiro, Grace Dourado, Thais Cesar
OBJECTIVE: Assumptions have linked orange juice (OJ) consumption with weight gain and adverse effects on health due to its sugar content; however, epidemiologic studies have not shown increased risk for overweight or obesity with the consumption of 100% OJ. The aim of this study was to verify whether the combination of a reduced-calorie diet (RCD) and 100% OJ contribute to weight loss, promote changes in glucose and lipid metabolism, and improve diet quality in obese individuals. METHODS: A randomized controlled trial with 78 obese patients (age 36 ± 1 y, body mass index [BMI] 33 ± 3 kg/m(2)) were enrolled in two groups: Individuals in the OJ group submitted to an RCD that included OJ (500 mL/d), and individuals in the control group submitted to an RCD without OJ...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526373/coffee-consumption-in-aged-mice-increases-energy-production-and-decreases-hepatic-mtor-levels
#9
Keita Takahashi, Shuichi Yanai, Kentaro Shimokado, Akihito Ishigami
OBJECTIVE: Coffee, one of the world's most consumed beverages, has many benefits. Some studies have reported the effects of coffee on aging. The aim of this study was to investigate the locomotor activity, energy metabolism, and lipid metabolism of aged (20-mo-old) mice given coffee. METHODS: Aged C57 BL/6 NCr mice were divided into three groups: controls that were not given coffee (n = 9), a group that received 0.1% caffeinated coffee (n = 9), and a group that received 0...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526006/cardiometabolic-profile-of-obese-children-in-a-sub-saharan-african-setting-a-cross-sectional-study
#10
Eunice Chedjou-Nono, Suzanne Sap, Simeon-Pierre Choukem, Issa Ngosso Tetanye, Daniel Nebongo, Olivier Koki Ndombo
BACKGROUND: Cardiovascular and metabolic consequences of obesity in children, unlike adults, are still not well understood nor have they been subject to extensive research in Africa. We aimed to identify the cardio-metabolic complications associated with childhood obesity at the early phase of the management of obese children in a reference center in Cameroon. METHODS: In this cross-sectional study conducted from November 2013 to September 2014 and based on World Health Organization (WHO) classification of Obesity (BMI > 3SD under 5 years and BMI > 2SD from 5 and above), we included children aged 3 to 17 years who were being followed up for obesity at the pediatric endocrinology unit of the Mother and Child Center of the Chantal BIYA Foundation in Yaounde, Cameroon...
May 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28523414/fully-navigated-3-t-proton-magnetic-resonance-spectroscopy-of-liver-metastases-with-inner-volume-saturation
#11
Carolin Reischauer, Andreas Hock, Orpheus Kolokythas, Christoph A Binkert, Andreas Gutzeit
PURPOSE: To demonstrate that fully navigated magnetic resonance spectroscopy (MRS) with inner-volume saturation (IVS) at 3 T results in high-quality spectra that permit evaluating metabolic changes in hepatic metastases without the need for patient compliance. METHODS: Nine patients with untreated, biopsy-proven large hepatic metastases (minimum diameter of 3 cm) were included. In each patient, localized proton MRS was performed in the metastatic lesion and in uninvolved liver parenchyma...
May 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28522351/effect-of-early-supplemental-parenteral-nutrition-in-the-paediatric-icu-a-preplanned-observational-study-of-post-randomisation-treatments-in-the-pepanic-trial
#12
Ilse Vanhorebeek, Sascha Verbruggen, Michaël P Casaer, Jan Gunst, Pieter J Wouters, Jan Hanot, Gonzalo Garcia Guerra, Dirk Vlasselaers, Koen Joosten, Greet Van den Berghe
BACKGROUND: Large randomised controlled trials have shown that early supplemental parenteral nutrition in patients admitted to adult and paediatric intensive care units (PICUs) is harmful. Overdosing of energy with too little protein was suggested as a potential reason for this. This study analysed which macronutrient was associated with harm caused by early supplemental parenteral nutrition in the Paediatric Early versus Late Parenteral Nutrition In Critical Illness (PEPaNIC) randomised trial...
May 15, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28521888/clinical-significance-of-lipid-rich-plaque%C3%A2-detected-by-optical-coherence%C3%A2-tomography-a%C3%A2-4-year-follow-up-study
#13
Lei Xing, Takumi Higuma, Zhao Wang, Aaron D Aguirre, Kyoichi Mizuno, Masamichi Takano, Harold L Dauerman, Seung-Jung Park, Yangsoo Jang, Chong-Jin Kim, Soo-Joong Kim, So-Yeon Choi, Tomonori Itoh, Shiro Uemura, Harry Lowe, Darren L Walters, Peter Barlis, Stephen Lee, Amir Lerman, Catalin Toma, Jack Wei Chieh Tan, Erika Yamamoto, Krzysztof Bryniarski, Jiannan Dai, Thomas Zanchin, Shaosong Zhang, Bo Yu, Hang Lee, James Fujimoto, Valentin Fuster, Ik-Kyung Jang
BACKGROUND: Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. OBJECTIVES: This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). METHODS: The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence tomography (OCT) imaging of the target vessel...
May 23, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28521869/high-fgf21-levels-are-associated-with-altered-bone-homeostasis-in-hiv-1-infected-patients
#14
José M Gallego-Escuredo, Maria Karuna Lamarca, Joan Villarroya, Joan C Domingo, Ma Gracia Mateo, Ma Del Mar Gutierrez, Francesc Vidal, Francesc Villarroya, Pere Domingo, Marta Giralt
BACKGROUND: Fibroblast growth factor-21 (FGF21) has emerged as an important regulator of glucose, lipid, and body weight homeostasis. However, recent experimental studies have reported that increased FGF21 levels may lead to bone loss. OBJECTIVE: To assess the relationship of serum FGF21 levels and altered bone homeostasis in HIV-1-infected patients. DESIGN: Cross-sectional study of 137 HIV-1-infected patients and 35 healthy controls conducted at the Hospital de la Santa Creu i Sant Pau, Barcelona...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28521812/radiotherapy-improves-serum-fatty-acids-and-lipid-profile-in-breast-cancer
#15
Sana Shaikh, Naseem Aslam Channa, Farha Naz Talpur, Muhammad Younis, Naila Tabassum
BACKGROUND: Breast cancer is a disease with diverse clinical symptoms, molecular profiles, and its nature to response its therapeutic treatments. Radiotherapy (RT), along with surgery and chemotherapy is a part of treatment in breast cancer. The aim of present study was to investigate pre and post treatment effects of radiotherapy in serum fatty acids and its lipids profile in patients with breast cancer. METHODS: In this comparative as well as follow up study, Serum fatty acids were performed by gas chromatography to investigate fatty acids and Microlab for analysis of lipid profile...
May 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28521062/relative-metabolizable-energy-values-for-fats-and-oils-in-young-broilers-and-adult-roosters
#16
M P Aardsma, R D Mitchell, C M Parsons
Our goal was to determine if relative bioavailability values (RBV) for fats and oils (lipids) determined in adult roosters are different than RBV determined with young broiler chickens. Lipids that were expected to have widely varying ME content were evaluated using a slope-ratio approach in adult roosters (Exp. 1) via the precision-fed rooster assay (PFRA) and broiler chicks via a growth assay (Exp. 2). The same lipids were tested in both experiments and were refined corn oil (RCO), a 2:1 blend of stearic acid (C18:0) with RCO (SAB1), a 1:1 blend of C18:0 with RCO (SAB2), tallow (TW), poultry fat (PF), and corn oil from a corn ethanol plant (DDGSCO)...
May 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28521012/the-effect-of-dl-l-isomers-and-dl-hydroxy-analog-administered-at-2-levels-as-dietary-sources-of-methionine-on-the-metabolic-and-antioxidant-parameters-and-growth-performance-of-turkeys
#17
J Jankowski, K Ognik, M Kubinska, A Czech, J Juskiewicz, Z Zdunczyk
A hypothesis was verified that dietary methionine (Met) improves the growth and antioxidant status of turkeys, and that its effects depend on dietary inclusion levels and sources. A total of 816 female Hybrid Converter turkeys was fed wheat-soybean meal-based diets supplemented with 3 sources of Met: DL-, L-isomers and DL-hydroxy analog (DLM, LM, and MHA, respectively). In 4 4-week periods (from one to 16 wk of age), dietary Met content corresponded to NRC (1994) recommendations or was increased by approximately 50% (in one to 8 wk by 44 to 46% and in 9 to 16 wk by 55 to 56% vs...
May 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28515643/quality-of-frozen-pork-from-pigs-fed-diets-containing-palm-kernel-meal-as-an-alternative-to-corn-meal
#18
Jeong Yeon An, Hae In Yong, So Yeon Kim, Han Bit Yoo, Yoo Yong Kim, Cheorun Jo
The objective of this study was to evaluate the effect of different levels of palm kernel meal (PKM), an alternative to corn, on the quality of pork. A total of 72 crossbred pigs ([Yorkshire × Landrace] × Duroc) were assigned into four dietary treatments (PKM level of 0, 4, 8, or 12%). After 12 wk, one pig of median weight in each pen was selected and slaughtered to analyze meat quality. The color, free radical scavenging activity, lipid oxidation, texture, composition of fatty acids, and sensory qualities of pork loin were evaluated post slaughter...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28515380/highly-selective-and-considerable-subcritical-butane-extraction-to-separate-abamectin-in-green-tea
#19
Yating Zhang, Lingbiao Gu, Fei Wang, Lingjun Kong, Huili Pang, Guangyong Qin
We specially carried out the subcritical butane extraction to separate abamectin from tea leaves. Four parameters, such as extraction temperature, extraction time, number of extraction cycles, and solid-liquid ratio were studied and optimized through the response surface methodology with design matrix developed by Box-Behnken. Seventeen experiments with three various factors and three variable levels were employed to investigate the effect of these parameters on the extraction of abamectin. Besides, catechins, theanine, caffeine, and aroma components were determined by both high-performance liquid chromatography and gas chromatography-mass spectrometry to evaluate the tea quality before and after the extraction...
May 17, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28514624/evacetrapib-and-cardiovascular-outcomes-in-high-risk-vascular-disease
#20
RANDOMIZED CONTROLLED TRIAL
A Michael Lincoff, Stephen J Nicholls, Jeffrey S Riesmeyer, Philip J Barter, H Bryan Brewer, Keith A A Fox, C Michael Gibson, Christopher Granger, Venu Menon, Gilles Montalescot, Daniel Rader, Alan R Tall, Ellen McErlean, Kathy Wolski, Giacomo Ruotolo, Burkhard Vangerow, Govinda Weerakkody, Shaun G Goodman, Diego Conde, Darren K McGuire, Jose C Nicolau, Jose L Leiva-Pons, Yves Pesant, Weimin Li, David Kandath, Simon Kouz, Naeem Tahirkheli, Denise Mason, Steven E Nissen
BACKGROUND: The cholesteryl ester transfer protein inhibitor evacetrapib substantially raises the high-density lipoprotein (HDL) cholesterol level, reduces the low-density lipoprotein (LDL) cholesterol level, and enhances cellular cholesterol efflux capacity. We sought to determine the effect of evacetrapib on major adverse cardiovascular outcomes in patients with high-risk vascular disease. METHODS: In a multicenter, randomized, double-blind, placebo-controlled phase 3 trial, we enrolled 12,092 patients who had at least one of the following conditions: an acute coronary syndrome within the previous 30 to 365 days, cerebrovascular atherosclerotic disease, peripheral vascular arterial disease, or diabetes mellitus with coronary artery disease...
May 18, 2017: New England Journal of Medicine
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