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Lipid ratio

L Baila-Rueda, A Cenarro, I Lamiquiz-Moneo, R Mateo-Gallego, A M Bea-Sanz, S Perez-Calahorra, V Marco-Benedi, F Civeira
Some oxysterols are precursors of bile acid synthesis and play an important role in cholesterol homeostasis. However, if they are involved in the pathogeny of genetic hypercholesterolemia has not been previously explored. We have studied non-cholesterol sterol markers of cholesterol synthesis (lanosterol and desmosterol) and oxysterols (7α-hydroxy-4-cholesten-3-one, 24S-hydroxycholesterol and 27-hydroxycholesterol) in 200 affected subjects with primary hypercholesterolemia of genetic origin, negative for mutations in LDLR, APOB, PCSK9 and APOE genes (non-FH GH) and 100 normolipemic controls...
October 18, 2016: Journal of Steroid Biochemistry and Molecular Biology
Ilaria Degano, Jacopo La Nasa, Elisa Ghelardi, Francesca Modugno, Maria Perla Colombini
Lipid binders have traditionally been determined in paintings by using gas chromatography/mass spectrometry (GC/MS) to identify the characteristic profiles and ratios of fatty acids . However, the presence of mixtures in contemporary and modern oil paints makes the GC/MS determination of fatty acids insufficient to fully characterize the lipid binding media. In this study we prove that triacylglycerol (TAG) profiling by high-performance liquid chromatography with high-resolution tandem mass spectrometry, using ESI in positive and negative ionization modes is highly effective...
December 1, 2016: Talanta
Casey T Clark, Alyson H Fleming, John Calambokidis, Nicholas M Kellar, Camryn D Allen, Krista N Catelani, Michelle Robbins, Nicole E Beaulieu, Debbie Steel, James T Harvey
Understanding reproductive rates of wild animal populations is crucially important for management and conservation. Assessing pregnancy status of free-ranging cetaceans has historically been difficult; however, recent advances in analytical techniques have allowed the diagnosis of pregnancy from small samples of blubber tissue. The primary objectives of this study were as follows: (i) to test the efficacy of blubber progesterone assays as a tool for diagnosing pregnancy in humpback whales (Megaptera novaeangliae); (ii) to estimate the pregnancy rate of humpback whales in Monterey Bay, California; and (iii) to investigate the relationship between stable isotopes and reproductive status of these whales...
2016: Conservation Physiology
K Denise Apperson, Gita Cherian
Flax seed is a rich source of α-linolenic acid (18:3 n-3). Feeding broiler birds flax seed can increase n-3 fatty acids in meat tissues. However, non-starch polysaccharides in flax seed decrease nutrient digestibility and can have a negative impact on bird performance and muscle fatty acid content. Addition of carbohydrase enzymes to flax-based broiler diets can decrease the anti-nutritive effects of non-starch polysaccharides. An experiment was conducted to investigate on the effect of flax seed and carbohydrase enzyme foregut morphology, muscle tissue, fatty acids, and bird performance...
October 19, 2016: Poultry Science
Aki S Havulinna, Marko Sysi-Aho, Mika Hilvo, Dimple Kauhanen, Reini Hurme, Kim Ekroos, Veikko Salomaa, Reijo Laaksonen
OBJECTIVE: Ceramides are molecular lipids implicated in apoptosis, inflammation, obesity, and insulin resistance. An earlier study reported that ceramides were associated with fatal outcome among patients with coronary heart disease. Here, we examined whether ceramides are associated with major adverse cardiovascular events (MACEs) among apparently healthy individuals. APPROACH AND RESULTS: FINRISK 2002 is a population-based risk factor survey, which recruited men and women aged 25 to 74 years...
October 20, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Rosa-M Valls, Elisabet Llauradó, Sara Fernández-Castillejo, Francesc Puiggrós, Rosa Solà, Lluis Arola, Anna Pedret
BACKGROUND: Oligopin(ۚ) (OP) is a quantified extract from French Maritime Pine bark (FMPB) with low molecular weight procyanidins. The cardioprotective effects of OP need to be tested in human clinical intervention trials with an appropriate design. PURPOSE: The aim of the present study was to assess the effect of subchronic consumption of OP on cardiovascular disease risk factors such as lipid profile, systolic blood pressure (BP) and oxidized-Low Density Lipoprotein (ox-LDL) in stage-1-hypertensive subjects...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Alexander N Shikov, Olga N Pozharitskaya, Valery G Makarov
PURPOSE: Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen syn. A. mandshurica Rupr. & Maxim is evaluated for its medicinal application. The aim of this study is to analyze pharmacological studies on A. elata var. mandshurica published until December 2015. METHODS: The information regarding the chemistry, safety, effectiveness, and pharmacological and clinical effects of A. elata was systematically collected from the scientific literature through library catalogs; online services such as E-library...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Kapil Suchal, Salma Malik, Nanda Gamad, Rajiv Kumar Malhotra, Sameer N Goyal, Jagriti Bhatia, Dharamvir Singh Arya
BACKGROUND: Myocardial infarction (MI) continues to be associated with high morbidity and mortality worldwide despite the availability of current therapeutic modalities. Kaempferol (KMP), a dietary flavonoid, possesses good antioxidant, immunomodulatory and anti-apoptotic properties and has been evaluated in the present study for its role in mitigating myocardial injury following MI. PURPOSE: In this study, the ability of KMP to protect heart against isoproterenol (ISO) induced oxidative stress and myocardial infarction was evaluated...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
P D Austin, K S Hand, M Elia
BACKGROUND: As lipid in parenteral nutrition (PN) purportedly enhances microbial growth, recommendations limit infusion of lipid PN (or lipid emulsion) from a single container to 24h (48h for lipid-free PN). However, the associated evidence base is ambiguous. AIM: To examine factors affecting microbial growth in PN. METHODS: A systematic review with meta-analyses examined effects of nutrients on microbial growth in PN infusates over a 48-h period using the growth ratio {GR=log10[colony-forming units (cfu)/mL at 48h/cfu/mL at time zero]}...
September 7, 2016: Journal of Hospital Infection
Yongbin Lu, Zhiyuan Cheng, Yaxue Zhao, Xiaoyu Chang, Cynthia Chan, Yana Bai, Ning Cheng
BACKGROUND AND AIMS: Our study aims to evaluate the efficacy and safety of long-term treatment of statins for coronary heart disease (CHD). METHODS: Efficacy outcomes included changes in blood lipids, risk of CHD mortality and all-cause mortality. Safety outcomes were evaluated by the risk of adverse events (AE). Bayesian network meta-analysis was used to compare the direct and indirect effects between different statins. RESULTS: The systematic review showed that levels of blood lipids decreased during statin treatment...
October 14, 2016: Atherosclerosis
Takao Sato, John Jose, Mohamed El-Mawardy, Dmitriy S Sulimov, Ralph Tölg, Gert Richardt, Mohamed Abdel-Wahab
This study investigated the predictors of acute recoil after implantation of everolimus-eluting BRS based on optical coherence tomography (OCT). Thirty-nine patients (56 scaffolds) were enrolled. Acute absolute recoil by quantitative coronary angiography was defined as the difference between the mean diameter of the last inflated balloon (X) and the mean lumen diameter of BRS immediately after balloon deflation (Y). Acute percent recoil was defined as (X - Y) × 100/X. Plaque eccentricity (PE) and plaque composition (PC) were assessed by OCT...
October 19, 2016: International Journal of Cardiovascular Imaging
M Jija Jose, Vipin Varkey, R Chandni, P A Zubaida, Jean Maliekkal
OBJECTIVE: To study the relation of smoking and abnormal renal function in type 2 diabetes mellitus by estimating urine protein- creatinine ratio, blood urea, serum creatinine, glomerular filtration rate and serum lipid profile in selected subjects. METHODS: Diabetic patients who attended the Diabetic Clinic, Medical College, Kozhikode were enrolled in the study. The study duration was 6 months, from July 2008 to December 2008. It was conducted in four groups of 40 subjects: diabetic smokers, diabetic non-smokers, non-diabetic smokers and non-diabetic non-smokers...
July 2016: Journal of the Association of Physicians of India
Mingwei Wan, Xiaoxu Li, Lianghui Gao, Weihai Fang
The self-assembly of phospholipid-coated gold nanorods (GNRs) was investigated by coarse-grained molecular dynamics simulations. We predict that in addition to the formation of deformed vesicles encapsulating GNRs with diverse orientations, the lipid-coated GNRs can form a semi-ring attached to an excess vesicle phase, a branch with excess vesicle phase, a ring phase, a branch phase, a stack phase, and a vortex phase. The morphologies of the lipid-GNR complexes depend on the lipid/GNR molar ratio and the interaction strength between the nanorod surface and the lipid head groups...
October 19, 2016: Nanotechnology
Hayder M Al-Kuraishy, Ali I Al-Gareeb
AIM: The objective of this study was to estimate the effect of orlistat alone and in combination with Garcinia cambogia on visceral adiposity index (VAI) in obese patients. PATIENTS AND METHODS: A total of 99 obese male patients were recruited with aged range between 37 and 46 years. They were randomized into three equal groups, first group treated with orlistat 120 mg/day, second group treated with G. cambogia 166 mg/day, and third group treated with orlistat 120 mg/day plus G...
September 2016: Journal of Intercultural Ethnopharmacology
Francisco Navarro, Eduardo Forján, María Vázquez, Zaida Montero, Elisabeth Bermejo, Miguel Ángel Castaño, Alberto Toimil, Enrique Chagüaceda, Miguel Ángel García-Sevillano, Marisa Sánchez, María José Domínguez, Rosario Pásaro, Inés Garbayo, Carlos Vílchez, José María Vega
BACKGROUND: Edible microalgae are marine or fresh water mesophilic species. Although the harvesting of microalgae offers an abundance of opportunities to the food and pharmaceutical industries, the possibility to use extremophilic microalgae as a food source for animals is not well-documented. OBJECTIVE: We studied the effects of dietary supplementation of a powdered form of the acidophilic microalga Coccomyxa onubensis on growth and health parameters of laboratory rats...
2016: Food & Nutrition Research
Jie-Eun Lee, Se Hee Min, Dong-Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo Lim
BACKGROUND: Early detection of atherogenic dyslipidemia is crucial. We investigated lipoprotein subfraction parameters according to glucose metabolism status. METHODS: We recruited 1255 lipid-lowering drug-naïve subjects with normal fasting glucose (NFG; n=200, 15.9%), impaired fasting glucose (IFG; n=443, 35.3%), or type 2 diabetes (T2D; n=612, 48.8%). Lipoprotein subfractions (1-7) were determined by polyacrylamide gel electrophoresis, separating low-density lipoprotein (LDL) into large buoyant LDL (lbLDL, LDL1-2) and small dense LDL (sdLDL, LDL3-7)...
October 6, 2016: International Journal of Cardiology
Lee Mozessohn, Craig Earle, David Spaner, Stephanie Y Cheng, Matthew Kumar, Rena Buckstein
BACKGROUND: Metabolic syndrome (MetS) is a risk factor for development of cancer. Because aberrant lipid metabolism is a pathogenic feature of chronic lymphocytic leukemia (CLL), our objective was to determine if CLL patients have a higher prevalence of MetS preceding diagnosis and to determine the impact of lipid-lowering medications on survival. METHODS: We conducted a population-based case-control study in Ontario, Canada, using administrative databases of adults age 66 years and older to compare the prevalence of MetS preceding CLL with age- and sex-matched control subjects...
March 2017: Journal of the National Cancer Institute
Elijah Ogola
OBJECTIVE: The prevalence of diabetes mellitus (DM) is rapidly increasing in Africa with a projected increase in diabetics from 12.1 million in 2010 to 23.9 million in 2030, predominantly type 2 DM (T2DM). The major consequence of diabetes is cardiovascular (CV) disease. T2DM occurs with a constellation of other CV risk factors (RF). Awareness and control of all risk factors is therefore critical in reducing the burden from diabetes. The rising burden has hitherto been an urban phenomenon; however there is evidence of rising burden in rural areas...
September 2016: Journal of Hypertension
Ming Liu, Lihua Li, Jihong Chu, Guoliang Dai, Wenzheng Ju, Zhenxing Wang, Zhuyuan Fang
OBJECTIVE: Nicotinamide N-methyltransferase (NNMT) is a novel histone methylation modulator that regulates energy metabolism, and NNMT knockdown prevents diet-induced obesity in mice. However, whether NNMT plays a role in human obesity and type 2 diabetes mellitus (T2DM) remains to be elucidated. NNMT catalyzes methylation of nicotinamide to generate N-methylnicotinamide (me-NAM). We aimed to investigate the associations of serum me-NAM with obesity and T2DM in Chinese. DESIGN AND METHOD: The study subjects (n = 1160) were recruited from Dali, a city of Yunan province, in southwest China...
September 2016: Journal of Hypertension
Rashmi Yadav, Raj Kumar Yadav, Rajesh Khadgawat, Nalin Mehta
OBJECTIVE: To study the effects of 12 week yoga-based lifestyle intervention on cardio-metabolic risk factors and adipocytokines in overweight/obese subjects with pre-hypertension [systolic blood pressure (SBP) 130-139 mmHg or diastolic blood pressure (DBP) 85-89 mmHg] or hypertension (HTN). DESIGN AND METHOD: This prospective, single arm, lifestyle intervention study was conducted in overweight/obese (body mass index; BMI 23-24.9/ ≥ 25 kg/m) subjects (n = 44), with pre-HTN or previously diagnosed HTN...
September 2016: Journal of Hypertension
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