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"Sam" "Parnia"

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https://www.readbyqxmd.com/read/27592156/effects-of-epinephrine-on-cerebral-oxygenation-during-cardiopulmonary-resuscitation-a-prospective-cohort-study
#1
Charles D Deakin, Jie Yang, Robert Nguyen, Jiawen Zhu, Stephen J Brett, Jerry P Nolan, Gavin D Perkins, David G Pogson, Sam Parnia
BACKGROUND: Epinephrine has been presumed to improve cerebral oxygen delivery during cardiopulmonary resuscitation (CPR), but animal and registry studies suggest that epinephrine-induced capillary vasoconstriction may decrease cerebral capillary blood flow and worsen neurological outcome. The effect of epinephrine on cerebral oxygenation (rSO2) during CPR has not been documented in the clinical setting. METHODS: rSO2 was measured continuously using cerebral oximetry in patients with in-hospital cardiac arrest...
December 2016: Resuscitation
https://www.readbyqxmd.com/read/27402395/association-of-arterial-oxygen-tension-during-in-hospital-cardiac-arrest-with-return-of-spontaneous-circulation-and-survival
#2
Jignesh K Patel, Elinor Schoenfeld, Puja B Parikh, Sam Parnia
BACKGROUND: Despite numerous advances in the delivery of resuscitative care, in-hospital cardiac arrest (IHCA) continues to be associated with high morbidity and mortality. We sought to study the impact of arterial oxygen tension (Pao 2) on return of spontaneous circulation (ROSC) and survival to discharge in patients with IHCA. METHODS: The study population included 255 consecutive patients who underwent advanced cardiac life support-guided resuscitation from January 2012 to December 2013 for IHCA at an academic tertiary medical center...
July 11, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/27071068/cerebral-oximetry-during-cardiac-arrest-a-multicenter-study-of-neurologic-outcomes-and-survival
#3
Sam Parnia, Jie Yang, Robert Nguyen, Anna Ahn, Jiawen Zhu, Loren Inigo-Santiago, Asad Nasir, Kim Golder, Shreyas Ravishankar, Pauline Bartlett, Jianjin Xu, David Pogson, Sarah Cooke, Christopher Walker, Ken Spearpoint, David Kitson, Teresa Melody, Mehboob Chilwan, Elinor Schoenfeld, Paul Richman, Barbara Mills, Nancy Wichtendahl, Jerry Nolan, Adam Singer, Stephen Brett, Gavin D Perkins, Charles D Deakin
OBJECTIVES: Cardiac arrest is associated with morbidity and mortality because of cerebral ischemia. Therefore, we tested the hypothesis that higher regional cerebral oxygenation during resuscitation is associated with improved return of spontaneous circulation, survival, and neurologic outcomes at hospital discharge. We further examined the validity of regional cerebral oxygenation as a test to predict these outcomes. DESIGN: Multicenter prospective study of in-hospital cardiac arrest...
September 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/26348423/making-sense-of-clinical-outcomes-following-cardiac-arrest
#4
REVIEW
Jignesh K Patel, Vikram Chabra, Sam Parnia
PURPOSE OF REVIEW: To provide a summary of the recent literature on clinical outcomes in adults with cardiac arrest, focusing on the impact of patient-specific factors in combination with cardio-pulmonary resuscitation (CPR) related, and postresuscitative-related factors. RECENT FINDINGS: Cardiac arrest is a major cause of morbidity and mortality worldwide. Despite the use of conventional cardiopulmonary resuscitation, rates of return of spontaneous circulation and survival with minimal neurologic impairment remain low...
October 2015: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/25922385/venoarterial-extracorporeal-membrane-oxygenation-in-adults-with-cardiac-arrest
#5
Jignesh K Patel, Elinor Schoenfeld, Sam Parnia, Adam J Singer, Norman Edelman
Cardiac arrest (CA) is a major cause of morbidity and mortality worldwide. Despite the use of conventional cardiopulmonary resuscitation (CPR), rates of return of spontaneous circulation and survival with minimal neurologic impairment remain low. Utilization of venoarterial extracorporeal membrane oxygenation (ECMO) for CA in adults is steadily increasing. Propensity-matched cohort studies have reported outcomes associated with ECMO use to be superior to that of conventional CPR alone in in-hospital patients with CA...
July 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/25418460/death-and-consciousness-an-overview-of-the-mental-and-cognitive-experience-of-death
#6
REVIEW
Sam Parnia
Advances in resuscitation science have indicated that, contrary to perception, death by cardiorespiratory criteria can no longer be considered a specific moment but rather a potentially reversible process that occurs after any severe illness or accident causes the heart, lungs, and brain to stop functioning. The resultant loss of vital signs of life (and life processes) is used to declare a specific time of death by physicians globally. When medical attempts are made to reverse this process, it is commonly referred to as cardiac arrest; however, when these attempts do not succeed or when attempts are not made, it is called death by cardiorespiratory criteria...
November 2014: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/25301715/aware-awareness-during-resuscitation-a-prospective-study
#7
MULTICENTER STUDY
Sam Parnia, Ken Spearpoint, Gabriele de Vos, Peter Fenwick, Diana Goldberg, Jie Yang, Jiawen Zhu, Katie Baker, Hayley Killingback, Paula McLean, Melanie Wood, A Maziar Zafari, Neal Dickert, Roland Beisteiner, Fritz Sterz, Michael Berger, Celia Warlow, Siobhan Bullock, Salli Lovett, Russell Metcalfe Smith McPara, Sandra Marti-Navarette, Pam Cushing, Paul Wills, Kayla Harris, Jenny Sutton, Anthony Walmsley, Charles D Deakin, Paul Little, Mark Farber, Bruce Greyson, Elinor R Schoenfeld
BACKGROUND: Cardiac arrest (CA) survivors experience cognitive deficits including post-traumatic stress disorder (PTSD). It is unclear whether these are related to cognitive/mental experiences and awareness during CPR. Despite anecdotal reports the broad range of cognitive/mental experiences and awareness associated with CPR has not been systematically studied. METHODS: The incidence and validity of awareness together with the range, characteristics and themes relating to memories/cognitive processes during CA was investigated through a 4 year multi-center observational study using a three stage quantitative and qualitative interview system...
December 2014: Resuscitation
https://www.readbyqxmd.com/read/25060142/reversing-death-the-miracle-of-modern-medicine
#8
Steve Paulson, Lance B Becker, Sam Parnia, Stephan A Mayer
Breakthroughs in emergency medicine have enabled science to halt and even reverse death. However, these advances have inadvertently led science into a domain that has traditionally been the purview of theology and philosophy. Steve Paulson, executive producer and host of To the Best of Our Knowledge, moderated a discussion that included emergency medicine experts Lance B. Becker and Sam Parnia, and neurosurgeon Stephan A. Mayer; they discussed recent discoveries and emerging technologies in resuscitation science and the ethical dilemmas they sometimes confront during medical crises...
November 2014: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/25059901/experiencing-death-an-insider-s-perspective
#9
Steve Paulson, Peter Fenwick, Mary Neal, Kevin Nelson, Sam Parnia
For millennia, human beings have wondered what happens after death. What is the first-person experience of dying and being brought back to life? Technological advances in resuscitation science have now added an intriguing new chapter to the literature of out-of-body or near-death experiences by eliciting detailed and vivid accounts of those who have approached the threshold of death. Steve Paulson, executive producer and host of To the Best of Our Knowledge, moderated a discussion that included neurologist Kevin Nelson, neuropsychiatrist Peter Fenwick, emergency medicine expert Sam Parnia, and orthopedic surgeon and drowning survivor Mary Neal; they share some remarkable stories and discuss how they analyze such experiences in light of their own backgrounds and training...
November 2014: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/24662518/cerebral-oximetry-levels-during-cpr-are-associated-with-return-of-spontaneous-circulation-following-cardiac-arrest-an-observational-study
#10
Adam J Singer, Anna Ahn, Loren A Inigo-Santiago, Henry C Thode, Mark C Henry, Sam Parnia
OBJECTIVES: Cerebral oximetry using near-infrared spectroscopy measures regional cerebral oxygen saturation (rSO2) non-invasively and may provide information regarding the quality of cerebral oxygen perfusion. We determined whether the level of rSO2 obtained during cardiopulmonary resuscitation is associated with return of spontaneous circulation (ROSC) and survival in Emergency Department (ED) patients presenting with cardiac arrest. METHODS: We conducted a retrospective, observational study of adult ED patients presenting at an academic medical centre with cardiac arrest in whom continuous cerebral oximetry was performed...
May 2015: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/24555532/autocrine-ligands-of-the-epithelial-growth-factor-receptor-mediate-inflammatory-responses-to-diesel-exhaust-particles
#11
Sam Parnia, Lynnsey M Hamilton, Sarah M Puddicombe, Stephen T Holgate, Anthony J Frew, Donna E Davies
BACKGROUND: Diesel exhaust is associated with cardiovascular and respiratory mortality and morbidity. Acute exposure leads to increased IL-8 expression and airway neutrophilia, however the mechanism of this response is unknown. OBJECTIVES: As cigarette smoke-induced IL-8 expression by epithelial cells involves transactivation of the epidermal growth factor receptor (EGFR), we studied the effects of diesel exhaust particles (DEP) on IL-8 release and the role of the EGFR...
February 20, 2014: Respiratory Research
https://www.readbyqxmd.com/read/24361675/a-feasibility-study-of-cerebral-oximetry-monitoring-during-the-post-resuscitation-period-in-comatose-patients-following-cardiac-arrest
#12
Anna Ahn, Jie Yang, Loren Inigo-Santiago, Sam Parnia
BACKGROUND: One of the major causes of death and neurological injury after cardiac arrest is delayed ischemia combined with oxygen free radical mediated reperfusion injury. Consequently determining the optimal balance between oxygen delivery and uptake in the brain using a reliable non-invasive monitoring system during the post-resuscitation period is of importance. In this observational study, we evaluated the feasibility of using cerebral oximetry during the post-resuscitation period in order to identify changes in regional cerebral oxygen saturation (rSO2) and its association with survival to discharge...
April 2014: Resuscitation
https://www.readbyqxmd.com/read/24247475/a-feasibility-study-of-cerebral-oximetry-during-in-hospital-mechanical-and-manual-cardiopulmonary-resuscitation
#13
Sam Parnia, Asad Nasir, Anna Ahn, Hanan Malik, Jie Yang, Jiawen Zhu, Francis Dorazi, Paul Richman
OBJECTIVE: A major hurdle limiting the ability to improve the quality of resuscitation has been the lack of a noninvasive real-time detection system capable of monitoring the quality of cerebral and other organ perfusion, as well as oxygen delivery during cardiopulmonary resuscitation. Here, we report on a novel system of cerebral perfusion targeted resuscitation. DESIGN: An observational study evaluating the role of cerebral oximetry (Equanox; Nonin, Plymouth, MI, and Invos; Covidien, Mansfield, MA) as a real-time marker of cerebral perfusion and oxygen delivery together with the impact of an automated mechanical chest compression system (Life Stat; Michigan Instruments, Grand Rapids, MI) on oxygen delivery and return of spontaneous circulation following in-hospital cardiac arrest...
April 2014: Critical Care Medicine
https://www.readbyqxmd.com/read/23948447/a-pilot-study-examining-the-role-of-regional-cerebral-oxygen-saturation-monitoring-as-a-marker-of-return-of-spontaneous-circulation-in-shockable-vf-vt-and-non-shockable-pea-asystole-causes-of-cardiac-arrest
#14
Anna Ahn, Asad Nasir, Hanan Malik, Francis D'Orazi, Sam Parnia
BACKGROUND: Non-invasive monitoring of cerebral perfusion and oxygen delivery during cardiac arrest is not routinely utilized during cardiac arrest resuscitation. The objective of this study was to investigate the feasibility of using cerebral oximetry during cardiac arrest and to determine the relationship between regional cerebral oxygen saturation (rSO2) with return of spontaneous circulation (ROSC) in shockable (VF/VT) and non-shockable (PEA/asystole) types of cardiac arrest. METHODS: Cerebral oximetry was applied to 50 in-hospital and out-of-hospital cardiac arrest patients...
December 2013: Resuscitation
https://www.readbyqxmd.com/read/23246514/does-induction-of-hypothermia-improve-outcomes-after-in-hospital-cardiac-arrest
#15
MULTICENTER STUDY
Graham Nichol, Ella Huszti, Francis Kim, Deborah Fly, Sam Parnia, Michael Donnino, Tori Sorenson, Clifton W Callaway
INTRODUCTION: Hypothermia improves neurologic recovery compared to normothermia after resuscitation from out-of-hospital ventricular fibrillation, but may or may not be beneficial for patients resuscitated from in-hospital cardiac arrest. Therefore, we evaluated the effect of induced hypothermia in a large cohort of patients with in-hospital cardiac arrest. METHODS: Retrospective analysis of multi-center prospective cohort of patients with in-hospital cardiac arrest enrolled in an ongoing quality improvement project...
May 2013: Resuscitation
https://www.readbyqxmd.com/read/22322284/a-feasibility-study-evaluating-the-role-of-cerebral-oximetry-in-predicting-return-of-spontaneous-circulation-in-cardiac-arrest
#16
Sam Parnia, Asad Nasir, Chirag Shah, Rajeev Patel, Anil Mani, Paul Richman
UNLABELLED: To date there has been no reliable noninvasive real time monitoring available to determine cerebral perfusion during cardiac arrest. OBJECTIVES: To investigate the feasibility of using a commercially available cerebral oximeter during in-hospital cardiac arrest, and determine whether this parameter predicts return of spontaneous circulation (ROSC). METHODS: Cerebral oximetry was incorporated in cardiac arrest management in 19 in-hospital cardiac arrest cases, five of whom had ROSC...
August 2012: Resuscitation
https://www.readbyqxmd.com/read/22062682/cerebral-oximetry-the-holy-grail-of-non-invasive-cerebral-perfusion-monitoring-in-cardiac-arrest-or-just-a-false-dawn
#17
EDITORIAL
Sam Parnia
No abstract text is available yet for this article.
January 2012: Resuscitation
https://www.readbyqxmd.com/read/17459598/do-reports-of-consciousness-during-cardiac-arrest-hold-the-key-to-discovering-the-nature-of-consciousness
#18
Sam Parnia
Perhaps the biggest challenge facing neuroscience at the dawn of the 21st century is understanding the relationship between mind, consciousness and the brain. Editorials in recent years have highlighted the difficulties faced by cognitive neuroscience in attempting to answer questions regarding the nature, as well as the mechanism by which subjective experiences and our sense of consciousness may arise through neuronal processes. Current scientific views regarding the origin of consciousness vary widely and range from an 'epiphenomenon' arising from neuronal networks, to neuronal quantum processes, to a separate undiscovered scientific entity...
2007: Medical Hypotheses
https://www.readbyqxmd.com/read/11801343/near-death-experiences-in-cardiac-arrest-visions-of-a-dying-brain-or-visions-of-a-new-science-of-consciousness
#19
REVIEW
Sam Parnia, Peter Fenwick
Very little is known about the dying process and in particular the state of the human mind at the end of life. Cardiac arrest is the final step in the dying process irrespective of cause, and is also the closest physiological model of the dying process. Recent studies in cardiac arrest survivors have indicated that although the majority of cardiac arrest survivors have no memory recall from the event, nevertheless approximately 10% develop memories that are consistent with typical near death experiences. These include an ability to 'see' and recall specific detailed descriptions of the resuscitation, as verified by resuscitation staff...
January 2002: Resuscitation
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