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T Brünnler, M Drey, G Dirrigl, C Weingart, F Rockmann, C Sieber, U Hoffmann
OBJECTIVES: The ageing population implicates an increasing numbers of older adults attending Emergency Departments (ED). We assessed the effect of estimated glomerular filtration rate as a predictor of clinical outcomes in oldest-old patients ≥ 85 years attending the ED in an university teaching hospital. DESIGN: Within three years, 81831 patient contacts were made in our ED. 7799 (9.5%) were older than 85 years, in whom we analyzed the impact of renal function on various outcome parameters...
2016: Journal of Nutrition, Health & Aging
Jeremy S Faust, Scott D Weingart
SEP-1, the new national quality measure on sepsis, resulted from an undertaking to standardize care for severe sepsis and septic shock regardless of the size of the emergency department where the patient is being treated. SEP-1 does not necessarily follow the best current evidence available. Nevertheless, a thorough understanding of SEP-1 is crucial because all hospitals and emergency providers will be accountable for meeting the requirements of this measure. SEP-1 is the first national quality measure on early management of sepsis care...
February 2017: Emergency Medicine Clinics of North America
Oliver G Weingart, Martin J Loessner
Botulinum neurotoxins (BoNT) are the most toxic substances known, and their neurotoxic properties and paralysing effects are exploited for medical treatment of a wide spectrum of disorders. To accurately quantify the potency of a pharmaceutical BoNT preparation, its physiological key activities (binding to membrane receptor, translocation, and proteolytic degradation of SNARE proteins) need to be determined. To date, this was only possible using animal models, or, to a limited extent, cell-based assays. We here report a novel in vitro system for BoNT/B analysis, based on nerve-cell mimicking liposomes presenting motoneuronal membrane receptors required for BoNT binding...
December 15, 2016: Toxicology and Applied Pharmacology
Matthew Wetherell, Megan Sweeney, Saul N Weingart
BACKGROUND: Current risk-stratification models insufficiently identify readmission risk. SETTING: Academic medical center in Boston, MA. PATIENTS: One hundred seventy-seven medicine inpatients. METHODS: We prospectively interviewed clinicians about whether they would be surprised if patients scheduled for discharge were readmitted within 30 days and to identify one patient at the highest risk. Multivariate models examined the impact of clinicians' judgment on readmission...
September 13, 2016: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
Mathias Wolters, Matthias Oelke, Bettina Lutze, Markus Weingart, Markus A Kuczyk, Iris F Chaberny, Karolin Graf
INTRODUCTION: Deep surgical site infections (DSSI) usually require secondary treatments. The aim of this study was to compare the total length of hospitalisation (LOH), intensive care unit (ICU) duration, and total treatment costs in patients with DSSI versus without DSSI after open radical cystectomy (ORC) and urinary diversion. MATERIAL AND METHODS: Prospective case-control study in a tertiary care hospital in patients after ORC with urinary diversion during April 2008 to July 2012...
September 14, 2016: Urologia Internationalis
Christiaan D M Wijers, Ryan Vagedes, Christine Weingart
BACKGROUND: Burkholderia cenocepacia is a Gram-negative, opportunistic pathogen that is a cause of morbidity and mortality in patients with cystic fibrosis (CF). Research efforts over the past few decades contributed to our understanding of these infections by identifying virulence factors. However, little is known about how this pathogen adapts to the harsh environment found inside the CF airways, which is characterized by a unique mucus containing high concentrations of inflammatory markers...
2016: BMC Microbiology
Ramona Mundt, Christian Torres Ziegenbein, Sascha Fröbel, Oliver Weingart, Peter Gilch
Bacterial spores are rich in calcium dipicolinate (CaDPA). The role of this compound in the high UV resistance of spore DNA and their unique DNA photochemistry is not yet clarified. Here, the photophysical properties of CaDPA dissolved in water are studied by means of steady-state and time-resolved spectroscopy as well as quantum chemistry. Upon 255 nm excitation, a fluorescence emission with a yield of 1.7 × 10(-5) is detected. This low yield is in line with a measured fluorescence lifetime of 110 fs. Transient absorption experiments point to further transitions with time constants of 92 ps and 6...
September 8, 2016: Journal of Physical Chemistry. B
Lidiane Leal Duarte, Fabiana Maria Coutinho Santos, Robert Weingart Barreto
Conyza canadensis is a noxious and notably problematic weed in Brazil whose control is greatly challenging due to the appearance, in the last years, of herbicide resistant populations. An investigation regarding the associated pathogenic fungi of this plant was conducted in Brazil aimed at starting a biological control program to help mitigate its economic impact. Ten fungal species were yielded and described: two ascomycetes (Leptosphaerulina conyzicola sp. nov. and Wentiomyces melioloides), five hyphomycete asexual morphs (Alternaria tenuissima, Cercospora conyzicola sp...
September 2016: Fungal Biology
Chad R Gordon, Ryan J Murphy, Mehran Armand, Peter Liacouras, Jon Weingart, Judy Huang, Henry Brem, Michael Lim
No abstract text is available yet for this article.
September 2016: Journal of Craniofacial Surgery
Sidney Zisook, Ilanit Tal, Kimberly Weingart, Paul Hicks, Lori L Davis, Peijun Chen, Jean Yoon, Gary R Johnson, Julia E Vertrees, Sanjai Rao, Patricia D Pilkinton, James A Wilcox, Mamta Sapra, Ali Iranmanesh, Grant D Huang, Somaia Mohamed
OBJECTIVE: Finding effective and lasting treatments for patients with Major Depressive Disorder (MDD) that fail to respond optimally to initial standard treatment is a critical public health imperative. Understanding the nature and characteristics of patients prior to initiating "next-step" treatment is an important component of identifying which specific treatments are best suited for individual patients. We describe clinical features and demographic characteristics of a sample of Veterans who enrolled in a "next-step" clinical trial after failing to achieve an optimal outcome from at least one well-delivered antidepressant trial...
July 26, 2016: Journal of Affective Disorders
Saul N Weingart, Elena M Stoffel, Daniel C Chung, Thomas D Sequist, Ruth I Lederman, Stephen R Pelletier, Helen M Shields
RATIONALE, AIMS AND OBJECTIVES: Variation in the workup of rectal bleeding may result in guideline-discordant care and delayed diagnosis of colorectal cancer. Accordingly, we undertook this study to characterize primary care clinicians' initial rectal bleeding evaluation. METHODS: We studied 438 patients at 10 adult primary care practices affiliated with three Boston, Massachusetts, academic medical centres and a multispecialty group practice, performing medical record reviews of subjects with visit codes for rectal bleeding, haemorrhoids or bloody stool...
July 20, 2016: Journal of Evaluation in Clinical Practice
Suzanne Shurtz, Virginia Fajt, Erla P Heyns, Hannah F Norton, Sandra Weingart
There is no comprehensive review of the extent to which evidence-based veterinary medicine (EBVM) is taught in AVMA-accredited colleges of veterinary medicine in the US and Canada. We surveyed teaching faculty and librarians at these institutions to determine what EBVM skills are currently included in curricula, how they are taught, and to what extent librarians are involved in this process. Librarians appear to be an underused resource, as 59% of respondents did not use librarians/library resources in teaching EBVM...
July 14, 2016: Journal of Veterinary Medical Education
Scott D Weingart
No abstract text is available yet for this article.
June 9, 2016: Annals of Emergency Medicine
P Shaw, D Weingart, T Bonner, B Watson, M T M Park, W Sharp, J P Lerch, M M Chakravarty
BACKGROUND: When children have marked problems with motor coordination, they often have problems with attention and impulse control. Here, we map the neuroanatomic substrate of motor coordination in childhood and ask whether this substrate differs in the presence of concurrent symptoms of attention-deficit/hyperactivity disorder (ADHD). METHOD: Participants were 226 children. All completed Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5)-based assessment of ADHD symptoms and standardized tests of motor coordination skills assessing aiming/catching, manual dexterity and balance...
August 2016: Psychological Medicine
Michael J Lauria, Stephen Rush, Scott D Weingart, Jason Brooks, Isabelle A Gallo
Psychological skills training (PST) is the systematic acquisition and practice of different psychological techniques to improve cognitive and technical performance. This training consists of three phases: education, skills acquisition and practice. Some of the psychological skills developed in this training include relaxation techniques, focusing and concentration skills, positive 'self-suggestion' and visualisation exercises. Since the middle of the 20th century, PST has been successfully applied by athletes, performing artists, business executives, military personnel and other professionals in high-risk occupations...
October 2016: Emergency Medicine Australasia: EMA
Amol K Narang, Kaisorn L Chaichana, Jon D Weingart, Kristin J Redmond, Michael Lim, Alessandro Olivi, Alfred Quinones-Hinojosa, Lawrence R Kleinberg
BACKGROUND: In patients with progressive low-grade glioma (LGG), the presence of new MRI enhancement is commonly used as an indicator of malignant degeneration, but its accuracy in this setting is uncertain. OBJECTIVE: We characterize the ability of new MRI enhancement to serve as a surrogate for histologic grade in patients with progressive LGG, and also explore the prognostic value of new MRI enhancement, pathologic grade, and extent of resection. METHODS: Patients at our institution with WHO grade II glioma diagnosed between 1994-2010 who underwent repeat biopsy or resection at progression were retrospectively reviewed (n=108)...
April 19, 2016: World Neurosurgery
Harpreet Kaur, Sabeen Zulfiqar Ali, Lauren Huey, Marianne Hütt-Cabezas, Isabella Taylor, Xing-Gang Mao, Melanie Weingart, Qian Chu, Fausto J Rodriguez, Charles G Eberhart, Eric H Raabe
Glioblastoma (GBM) contains a population of stem-like cells that promote tumor invasion and resistance to therapy. Identifying and targeting stem cell factors in GBM may lead to the development of more effective therapies. High Mobility Group AT-hook 2 (HMGA2) is a transcriptional modulator that mediates motility and self-renewal in normal and cancer stem cells. We identified increased expression of HMGA2 in the majority of primary human GBM tumors and cell lines compared to normal brain. Additionally, HMGA2 expression was increased in CD133+ GBM neurosphere cells compared to CD133- cells...
July 10, 2016: Cancer Letters
Charles van den Heuvel, Scott B Weingart, Nils Spelt, Henk Nellen
Science in the early modern world depended on openness in scholarly communication. On the other hand, a web of commercial, political, and religious conflicts required broad measures of secrecy and confidentiality; similar measures were integral to scholarly rivalries and plagiarism. This paper analyzes confidentiality and secrecy in intellectual and technological knowledge exchange via letters and drawings. We argue that existing approaches to understanding knowledge exchange in early modern Europe--which focus on the Republic of Letters as a unified entity of corresponding scholars--can be improved upon by analyzing multilayered networks of communication...
2016: Nuncius
Zev A Binder, Kelli M Wilson, Vafi Salmasi, Brent A Orr, Charles G Eberhart, I-Mei Siu, Michael Lim, Jon D Weingart, Alfredo Quinones-Hinojosa, Chetan Bettegowda, Amin B Kassam, Alessandro Olivi, Henry Brem, Gregory J Riggins, Gary L Gallia
OBJECTIVE: Human tumor cell lines form the basis of the majority of present day laboratory cancer research. These models are vital to studying the molecular biology of tumors and preclinical testing of new therapies. When compared to traditional adherent cell lines, suspension cell lines recapitulate the genetic profiles and histologic features of glioblastoma multiforme (GBM) with higher fidelity. Using a modified neural stem cell culture technique, here we report the characterization of GBM cell lines including GBM variants...
2016: PloS One
Oliver C Thiele, Matthias Kreppel, Gido Bittermann, Lars Bonitz, Maria Desmedt, Carsten Dittes, Annegret Dörre, Anton Dunsche, Alexander W Eckert, Michael Ehrenfeld, Bernd Fleiner, Bernhard Frerich, Alexander Gaggl, Marcus Gerressen, Leonore Gmelin, Andreas Hammacher, Stefan Haßfeld, Max Heiland, Alexander Hemprich, Johannes Hidding, Frank Hölzle, Hans-Peter Howaldt, Tateyuki Iizuka, Wolfgang Kater, Cornelius Klein, Martin Klein, Robert H Köhnke, Andreas Kolk, Alexander C Kübler, Norbert R Kübler, Martin Kunkel, Johannes J Kuttenberger, Thomas Kreusch, Constantin Landes, Bernhard Lehner, Robert A Mischkowski, Steffen Mokros, Andreas Neff, Emeka Nkenke, Frank Palm, Gerhard W Paulus, Jörn U Piesold, Michael Rasse, Herbert Rodemer, Daniel Rothamel, Jan Rustemeyer, Robert Sader, Martin Scheer, Birgit Scheffler, Christian Schippers, Henning Schliephake, Rainer Schmelzeisen, Alexander Schramm, Wolfgang J Spitzer, Christian Stoll, Hendrik Terheyden, Dieter Weingart, Jörg Wiltfang, Klaus D Wolff, Christoph M Ziegler, Joachim E Zöller
Orthognathic surgery has always been a classical focus of maxillofacial surgery. Since more than 100 years, various surgical techniques for mandibular repositioning have been developed and clinically tested. Since the establishment of plate and screw osteosynthesis, orthognathic surgery became more stable and safe. Nowadays, different surgical methods for mobilising the mandible are existing. This international multicenter analysis (n = 51 hospitals) is providing first evidence based data for the current use of different surgical methods...
May 2016: Journal of Cranio-maxillo-facial Surgery
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