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https://www.readbyqxmd.com/read/29792461/teamwork-in-the-intensive-care-unit
#1
Jennifer N Ervin, Jeremy M Kahn, Taya R Cohen, Laurie R Weingart
Intensive care units (ICUs) provide care to the most severely ill hospitalized patients. Although ICUs increasingly rely on interprofessional teams to provide critical care, little about actual teamwork in this context is well understood. The ICU team is typically comprised of physicians or intensivists, clinical pharmacists, respiratory therapists, dieticians, bedside nurses, clinical psychologists, and clinicians-in-training. ICU teams are distinguished from other health care teams in that they are low in temporal stability, which can impede important team dynamics...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29791163/on-the-relationship-between-excited-state-lifetime-and-isomerization-quantum-yield-in-animal-rhodopsins-beyond-the-one-dimensional-landau-zener-model
#2
Mohsen M T El-Tahawy, Artur Nenov, Oliver Weingart, Massimo Olivucci, Marco Garavelli
We show that the speed of the chromophore photoisomerization of animal rhodopsins is not a relevant control knob for their light sensitivity. This result is at odd with the momentum-driven tunnelling rationale (i.e., assuming a one-dimensional Landau-Zener model for the decay: Zener, C. "Non-Adiabatic Crossing of Energy Levels", Proceedings of the Royal Society of London. Series A 1932, 137 (833), 696-702) holding that a faster nuclear motion through the conical intersection translates into a higher quantum yield and, thus, light sensitivity...
May 23, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29717985/-calcitriol-induced-hypercalcemia-in-a-hunting-dog-with-a-disseminated-paecilomyces-variotii-infection
#3
C Weingart, J Raila, A Lübke-Becker, O Kershaw, M Brunnberg, B Kohn
A 5-year old hunting dog was presented with reduced appetite, weight loss and polyuria/polydipsia. Hematology and clinical chemistry revealed anemia, leukocytosis, increased liver enzymes, hypoalbuminemia and hypercalcemia. The cytological, pathohistological and microbiological examination identified a disseminated infection with the saprophytic mould fungus Paecilomyces variotii in the biopsies of the spleen and a lymph node. Determination of vitamin D metabolites confirmed a calcitriol induced hypercalcemia...
May 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29611527/chemotherapy-medication-errors
#4
REVIEW
Saul N Weingart, Lulu Zhang, Megan Sweeney, Michael Hassett
Although chemotherapy is a well established treatment modality, chemotherapy errors represent a potentially serious risk of patient harm. We reviewed published research from 1980 to 2017 to understand the extent and nature of medication errors in cancer chemotherapy, and to identify effective interventions to help prevent mistakes. Chemotherapy errors occur at a rate of about one to four per 1000 orders, affect at least 1-3% of adult and paediatric oncology patients, and occur at all stages of the medication use process...
April 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29526412/current-concepts-in-cleft-care-a-multicenter-analysis
#5
Oliver C Thiele, Matthias Kreppel, Anton Dunsche, Andre M Eckardt, Michael Ehrenfeld, Bernd Fleiner, Volker Gaßling, Gerd Gehrke, Marcus Gerressen, Martin Gosau, Alexander Gröbe, Stefan Haßfeld, Max Heiland, Bodo Hoffmeister, Frank Hölzle, Cornelius Klein, Maximilian Krüger, Alexander C Kübler, Norbert R Kübler, Johannes J Kuttenberger, Constantin Landes, Günter Lauer, Markus Martini, Erich T Merholz, Robert A Mischkowski, Bilal Al-Nawas, Emeka Nkenke, Jörn U Piesold, Winnie Pradel, Michael Rasse, Martin Rachwalski, Rudolf H Reich, Daniel Rothamel, Jan Rustemeyer, Martin Scheer, Henning Schliephake, Rainer Schmelzeisen, Alexander Schramm, Wiebke Schupp, Wolfgang J Spitzer, Erwin Stocker, Christian Stoll, Hendrik Terheyden, Alexander Voigt, Wilfried Wagner, Dieter Weingart, Richard Werkmeister, Jörg Wiltfang, Christoph M Ziegler, Joachim E Zöller
The current surgical techniques used in cleft repair are well established, but different centers use different approaches. To determine the best treatment for patients, a multi-center comparative study is required. In this study, we surveyed all craniofacial departments registered with the German Society of Maxillofacial Surgery to determine which cleft repair techniques are currently in use. Our findings revealed much variation in cleft repair between different centers. Although most centers did use a two-stage approach, the operative techniques and timing of lip and palate closure were different in every center...
April 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29489570/adult-cranioplasty-reconstruction-with-customized-cranial-implants-preferred-technique-timing-and-biomaterials
#6
Amir Wolff, Gabriel F Santiago, Micah Belzberg, Charity Huggins, Michael Lim, Jon Weingart, William Anderson, Alex Coon, Judy Huang, Henry Brem, Chad Gordon
INTRODUCTION: Complex cranial defects requiring delayed reconstruction present numerous challenges. Delayed cranioplasties accompany frequent complications approaching an incidence of 35 to 40%. Therefore, the authors sought to collate their experience in hopes of sharing their perspective on several topics including technique, timing, and preferred biomaterials. METHODS: The authors' 5-year consecutive experience over 430 customized cranial implants is described herein...
February 27, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29419566/risk-factors-for-adverse-events-in-patients-with-breast-colorectal-and-lung-cancer
#7
Saul N Weingart, Coral L Atoria, David Pfister, David Classen, Aileen Killen, Elizabeth Fortier, Andrew S Epstein, Christopher Anderson, Allison Lipitz-Snyderman
OBJECTIVE: The aim of the study was to identify risk factors associated with medical errors and iatrogenic injuries during an initial course of cancer-directed treatment. METHODS: In this retrospective cohort study of 400 patients 18 years or older undergoing an initial course of treatment for breast, colorectal, or lung cancer at a comprehensive cancer center, we abstracted patient, disease, and treatment-related variables from the electronic medical record. We examined adverse events (AEs) and preventable AEs by risk factor using the χ or Fisher exact tests...
February 6, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29410020/impact-of-2-generational-improvements-in-colonoscopes-on-adenoma-miss-rates-results-of-a-prospective-randomized-multicenter-tandem-study
#8
Mathieu Pioche, Angélique Denis, Hans-Dieter Allescher, Gianluca Andrisani, Guido Costamagna, Evelien Dekker, Paul Fockens, Christian Gerges, Stefan Groth, Jennis Kandler, Isabelle Lienhart, Horst Neuhaus, Lucio Petruzziello, Guido Schachschal, Kristien Tytgat, Jürgen Wallner, Vincens Weingart, Sandrine Touzet, Thierry Ponchon, Thomas Rösch
BACKGROUND AND AIMS: Numerous randomized studies have shown that changing certain features of colonoscopes, usually incorporated when switching from one endoscope generation to the next, mostly do not increase adenoma yield. There is, however, indirect evidence that it may be necessary to skip one instrument generation (ie, changing from one generation to the next but one) to achieve this effect. METHODS: We compared the latest-generation colonoscopes from one company (Olympus Exera III, 190-C) with the next to last one (Olympus 160/5-C) in a prospective multicenter study randomized for the order of colonoscopes in a tandem fashion, involving 2 different examiners...
February 4, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29383356/the-effect-of-solvent-relaxation-in-the-ultrafast-time-resolved-spectroscopy-of-solvated-benzophenone
#9
Elena Zvereva, Javier Segarra-Martí, Marco Marazzi, Johanna Brazard, Artur Nenov, Oliver Weingart, Jérémie Léonard, Marco Garavelli, Ivan Rivalta, Elise Dumont, Xavier Assfeld, Stefan Haacke, Antonio Monari
Benzophenone (BP) despite its relatively simple molecular structure is a paradigmatic sensitizer, featuring both photocatalytic and photobiological effects due to its rather complex photophysical properties. In this contribution we report an original theoretical approach to model realistic, ultra-fast spectroscopy data, which requires describing intra- and intermolecular energy and structural relaxation. In particular we explicitly simulate time-resolved pump-probe spectra using a combination of state-of-the art hybrid quantum mechanics/molecular mechanics dynamics to treat relaxation and vibrational effects...
March 14, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29332604/the-effect-of-an-adenosine-a-2a-agonist-on-intra-tumoral-concentrations-of-temozolomide-in-patients-with-recurrent-glioblastoma
#10
Sadhana Jackson, Jon Weingart, Edjah K Nduom, Thura T Harfi, Richard T George, Dorothea McAreavey, Xiaobu Ye, Nicole M Anders, Cody Peer, William D Figg, Mark Gilbert, Michelle A Rudek, Stuart A Grossman
BACKGROUND: The blood-brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A2A receptors causes transient BBB disruption and increased drug concentrations in normal brain. This study was conducted to evaluate if activation of A2A receptors would increase intra-tumoral temozolomide concentrations in patients with glioblastoma. METHODS: Patients scheduled for a clinically indicated surgery for recurrent glioblastoma were eligible...
January 15, 2018: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29298580/promises-and-reservations-towards-science-and-technology-among-south-african-publics-a-culture-sensitive-approach
#11
Lars Guenther, Peter Weingart
Against the background that surveys measuring public perceptions of science and technology are often removed from cultural contexts and do not equally represent all regions of the world, this study investigated attitudes towards science and technology among different publics of the South African population. To apply a culture-sensitive approach, theoretical considerations of cultural distance were combined with methodological considerations of segmentation studies, and representative data ( n = 3183) were reanalysed...
February 1, 2017: Public Understanding of Science
https://www.readbyqxmd.com/read/29145923/cjem-debate-series-socialmedia-social-media-has-created-emergency-medicine-celebrities-who-now-influence-practice-more-than-published-evidence
#12
Peter Cameron, Simon Carley, Scott Weingart, Paul Atkinson
No abstract text is available yet for this article.
November 2017: CJEM
https://www.readbyqxmd.com/read/29138616/-bipolaris-marantae-sp-nov-a-novel-helminthosporoid-species-causing-foliage-blight-of-the-garden-plant-maranta-leuconeura-in-brazil
#13
Carla Cristina Gomes Lourenço, Janaina Lana Alves, Eduardo Guatimosim, Adans Colman, Robert Weingart Barreto
A severe leaf spot, turning to foliage blight, was observed on leaves of Maranta leuconeura growing in a garden in Brazil (state of Rio de Janeiro) in 2015. A dematiaceous hyphomycete bearing a morphology typical of a helminthosporoid fungi was regularly found in association with diseased tissues. The fungus was isolated and pathogenicity was demonstrated through the completion of Koch's postulates. A morphology and molecular analysis led to the conclusion that the fungus belonged to the genus Bipolaris , which is characterized by having fusiform conidia, externally thickened and truncate hila and a bipolar pattern of germination...
September 2017: Mycobiology
https://www.readbyqxmd.com/read/29132174/feasibility-safety-and-diagnostic-yield-of-the-extra-wide-angle-view-ewave-colonoscope-for-the-detection-of-colorectal-lesions
#14
Maxime E S Bronzwaer, Evelien Dekker, Vincens Weingart, Stefan Groth, Mathieu Pioche, Jérôme Rivory, Torsten Beyna, Horst Neuhaus, Thierry Ponchon, Hans Allescher, Paul Fockens, Thomas Rösch
BACKGROUND AND STUDY AIMS:  The adenoma detection rate (ADR) of conventional colonoscopy can still be improved. We conducted a prospective multicenter cohort study to assess the feasibility, safety, and diagnostic yield of the Extra Wide Angle View (EWAVE) colonoscope, which offers a 235° view obtained from a forward-viewing and two lateral backward-viewing lenses incorporated into one image. PATIENTS AND METHODS:  The study was performed between November 2015 and June 2016...
January 2018: Endoscopy
https://www.readbyqxmd.com/read/29067706/introduction-festschrift-in-honor-of-prof-volker-bu%C3%A3
#15
Igor Schapiro, Oliver Weingart
No abstract text is available yet for this article.
November 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29042332/the-relevance-of-simpson-grade-resections-in-modern-neurosurgical-treatment-of-world-health-organization-grade-i-ii-and-iii-meningiomas
#16
Jeff S Ehresman, Tomas Garzon-Muvdi, Davis Rogers, Michael Lim, Gary L Gallia, Jon Weingart, Henry Brem, Chetan Bettegowda, Kaisorn L Chaichana
OBJECTIVE: The Simpson grading system has played an important role in surgical resections of meningiomas. The aim of this study was to determine if this grading system predicts meningioma recurrence in a modern cohort of patients with tumors of all World Health Organization grades. METHODS: Adult patients who underwent primary, nonbiopsy resection of a meningioma at a tertiary care institution between 2007 and 2015 were retrospectively reviewed. Stepwise multivariate proportional hazard analyses were used to identify associations with recurrence after resection...
January 2018: World Neurosurgery
https://www.readbyqxmd.com/read/28926259/dual-photochemical-reaction-pathway-in-flavin-based-photoreceptor-lov-domain-a-combined-quantum-mechanics-molecular-mechanics-investigation
#17
Setsuko Nakagawa, Oliver Weingart, Christel M Marian
The primary photochemical reaction of the light, oxygen, and voltage (LOV) domain of the blue-light photosensor YtvA of Bacillus subtilis were investigated using high-level QM(DFT/MRCI)/MM methods. After blue-light excitation, the Sγ atom of the reactive cysteine forms a covalent bond with the C4a of the flavin mononucleotide (FMN) ring. Two conformations for the side chain of reactive cysteine with occupancies of 70% (conf A) and 30% (conf B) are observed in the X-ray crystallographic structures of the YtvA-LOV ( Möglich , A...
October 4, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28901718/chondroitin-sulfate-proteoglycans-negatively-regulate-the-positioning-of-mitochondria-and-endoplasmic-reticulum-to-distal-axons
#18
Rajiv Sainath, Lorena Armijo-Weingart, Andrea Ketscheck, Zhuxuan Xu, Shuxin Li, Gianluca Gallo
Chondroitin sulfate proteoglycans (CSPGs) are components of the extracellular matrix that inhibit the extension and regeneration of axons. However, the underlying mechanism of action remains poorly understood. Mitochondria and endoplasmic reticulum (ER) are functionally inter-linked organelles important to axon development and maintenance. We report that CSPGs impair the targeting of mitochondria and ER to the growth cones of chicken embryonic sensory axons. The effect of CSPGs on the targeting of mitochondria is blocked by inhibition of the LAR receptor for CSPGs...
December 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28874949/sepsis-definitions-the-search-for-gold-and-what-cms-got-wrong
#19
REVIEW
Annahieta Kalantari, Haney Mallemat, Scott D Weingart
On October 1, 2015, the United States Centers for Medicare and Medicaid Services (CMS) issued a core measure addressing the care of septic patients. These core measures are controversial among healthcare providers. This article will address that there is no gold standard definition for sepsis, severe sepsis or septic shock and the CMS-assigned definitions for severe sepsis and septic shock are premature and inconsistent with evidence-based definitions.
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28845353/developing-and-testing-the-health-care-safety-hotline-a-prototype-consumer-reporting-system-for-patient-safety-events
#20
Eric C Schneider, M Susan Ridgely, Denise D Quigley, Lauren E Hunter, Kristin J Leuschner, Saul N Weingart, Joel S Weissman, Karen P Zimmer, Robert C Giannini
This article describes the design, development, and testing of the Health Care Safety Hotline, a prototype consumer reporting system for patient safety events. The prototype was designed and developed with ongoing review by a technical expert panel and feedback obtained during a public comment period. Two health care delivery organizations in one metropolitan area collaborated with the researchers to demonstrate and evaluate the system. The prototype was deployed and elicited information from patients, family members, and caregivers through a website or an 800 phone number...
June 2017: Rand Health Quarterly
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