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https://www.readbyqxmd.com/read/29145923/cjem-debate-series-socialmedia-social-media-has-created-emergency-medicine-celebrities-who-now-influence-practice-more-than-published-evidence
#1
Peter Cameron, Simon Carley, Scott Weingart, Paul Atkinson
No abstract text is available yet for this article.
November 2017: CJEM
https://www.readbyqxmd.com/read/29138616/bipolaris-marantae-sp-nov-a-novel-helminthosporoid-species-causing-foliage-blight-of-the-garden-plant-maranta-leuconeura-in-brazil
#2
Carla Cristina Gomes Lourenço, Janaina Lana Alves, Eduardo Guatimosim, Adans Colman, Robert Weingart Barreto
A severe leaf spot, turning to foliage blight, was observed on leaves of Maranta leuconeura growing in a garden in Brazil (state of Rio de Janeiro) in 2015. A dematiaceous hyphomycete bearing a morphology typical of a helminthosporoid fungi was regularly found in association with diseased tissues. The fungus was isolated and pathogenicity was demonstrated through the completion of Koch's postulates. A morphology and molecular analysis led to the conclusion that the fungus belonged to the genus Bipolaris, which is characterized by having fusiform conidia, externally thickened and truncate hila and a bipolar pattern of germination...
September 2017: Mycobiology
https://www.readbyqxmd.com/read/29132174/feasibility-safety-and-diagnostic-yield-of-the-extra-wide-angle-view-ewave-colonoscope-for-the-detection-of-colorectal-lesions
#3
Maxime E S Bronzwaer, Evelien Dekker, Vincens Weingart, Stefan Groth, Mathieu Pioche, Jérôme Rivory, Torsten Beyna, Horst Neuhaus, Thierry Ponchon, Hans Allescher, Paul Fockens, Thomas Rösch
Background and study aims The adenoma detection rate (ADR) of conventional colonoscopy can still be improved. We conducted a prospective multicenter cohort study to assess the feasibility, safety, and diagnostic yield of the Extra Wide Angle View (EWAVE) colonoscope, which offers a 235° view obtained from a forward-viewing and two lateral backward-viewing lenses incorporated into one image. Patients and methods The study was performed between November 2015 and June 2016. EWAVE colonoscopy was performed in patients with an increased risk of colorectal cancer by experienced and EWAVE-trained endoscopists (≥ 500 colonoscopies, ≥ 10 with the EWAVE system)...
November 13, 2017: Endoscopy
https://www.readbyqxmd.com/read/29067706/introduction-festschrift-in-honor-of-prof-volker-bu%C3%A3
#4
Igor Schapiro, Oliver Weingart
No abstract text is available yet for this article.
November 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29042332/the-relevance-of-simpson-grade-resectionsin-the-modern-neurosurgical-treatment-of-world-health-organization-grade-1-2-and-3meningiomas
#5
Jeff S Ehresman, Tomas Garzon-Muvdi, Davis Rogers, Michael Lim, Gary L Gallia, Jon Weingart, Henry Brem, Chetan Bettegowda, Kaisorn L Chaichana
OBJECT: The Simpson grading system has played an important role in the surgical resections of meningiomas. This study set out to determine if this grading system predicts meningioma recurrence in a modern cohort of patients with tumors of all World Health Organization (WHO) grades. METHODS: Adult patients who underwent primary, non-biopsy resection of a meningioma at a tertiary care institution between 2007 and 2015 were retrospectively reviewed. Stepwise multivariate proportional hazard analyses were used to identify associations with recurrence following resection...
October 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28926259/dual-photochemical-reaction-pathway-in-flavin-based-photoreceptor-lov-domain-a-combined-quantum-mechanics-molecular-mechanics-investigation
#6
Setsuko Nakagawa, Oliver Weingart, Christel M Marian
The primary photochemical reaction of the light, oxygen, and voltage (LOV) domain of the blue-light photosensor YtvA of Bacillus subtilis were investigated using high-level QM(DFT/MRCI)/MM methods. After blue-light excitation, the Sγ atom of the reactive cysteine forms a covalent bond with the C4a of the flavin mononucleotide (FMN) ring. Two conformations for the side chain of reactive cysteine with occupancies of 70% (conf A) and 30% (conf B) are observed in the X-ray crystallographic structures of the YtvA-LOV ( Möglich , A...
October 4, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28901718/chondroitin-sulfate-proteoglycans-negatively-regulate-the-positioning-of-mitochondria-and-endoplasmic-reticulum-to-distal-axons
#7
Rajiv Sainath, Lorena Armijo-Weingart, Andrea Ketscheck, Zhuxuan Xu, Shuxin Li, Gianluca Gallo
Chondroitin sulfate proteoglycans (CSPGs) are components of the extracellular matrix that inhibit the extension and regeneration of axons. However, the underlying mechanism of action remains poorly understood. Mitochondria and endoplasmic reticulum (ER) are functionally inter-linked organelles important to axon development and maintenance. We report that CSPGs impair the targeting of mitochondria and ER to the growth cones of chicken embryonic sensory axons. The effect of CSPGs on the targeting of mitochondria is blocked by inhibition of the LAR receptor for CSPGs...
December 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28874949/sepsis-definitions-the-search-for-gold-and-what-cms-got-wrong
#8
REVIEW
Annahieta Kalantari, Haney Mallemat, Scott D Weingart
On October 1, 2015, the United States Centers for Medicare and Medicaid Services (CMS) issued a core measure addressing the care of septic patients. These core measures are controversial among healthcare providers. This article will address that there is no gold standard definition for sepsis, severe sepsis or septic shock and the CMS-assigned definitions for severe sepsis and septic shock are premature and inconsistent with evidence-based definitions.
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28845353/developing-and-testing-the-health-care-safety-hotline-a-prototype-consumer-reporting-system-for-patient-safety-events
#9
Eric C Schneider, M Susan Ridgely, Denise D Quigley, Lauren E Hunter, Kristin J Leuschner, Saul N Weingart, Joel S Weissman, Karen P Zimmer, Robert C Giannini
This article describes the design, development, and testing of the Health Care Safety Hotline, a prototype consumer reporting system for patient safety events. The prototype was designed and developed with ongoing review by a technical expert panel and feedback obtained during a public comment period. Two health care delivery organizations in one metropolitan area collaborated with the researchers to demonstrate and evaluate the system. The prototype was deployed and elicited information from patients, family members, and caregivers through a website or an 800 phone number...
June 2017: Rand Health Quarterly
https://www.readbyqxmd.com/read/28833170/new-perspectives-on-an-old-issue-a-comparative-ms-caspt2-and-om2-mrci-study-of-polyenes-and-protonated-schiff-bases
#10
Irina Dokukina, Christel M Marian, Oliver Weingart
Polyenic systems are involved in light perception of numerous living organisms. Although a π-conjugated backbone is a common feature of all polyenes, their photophysics may vary. We provide a comparative quantum mechanical study of low-lying S1 and S2 excited states in short (3-5 double bonds) symmetric all-trans linear polyenes and corresponding protonated Schiff bases. In our investigation, we use the well-established ab initio multireference CASPT2 approach and benchmark the efficient semiempirical OM2-MRCI approach against it...
November 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28817180/preventable-and-mitigable-adverse-events-in-cancer-care-measuring-risk-and-harm-across-the-continuum
#11
Allison Lipitz-Snyderman, David Pfister, David Classen, Coral L Atoria, Aileen Killen, Andrew S Epstein, Christopher Anderson, Elizabeth Fortier, Saul N Weingart
BACKGROUND: Patient safety is a critical concern in clinical oncology, but the ability to measure adverse events (AEs) across cancer care is limited by a narrow focus on treatment-related toxicities. The objective of this study was to assess the nature and extent of AEs among cancer patients across inpatient and outpatient settings. METHODS: This was a retrospective cohort study of 400 adult patients selected by stratified random sampling who had breast (n = 128), colorectal (n = 136), or lung cancer (n = 136) treated at a comprehensive cancer center in 2012...
December 1, 2017: Cancer
https://www.readbyqxmd.com/read/28717918/-syncope-falls-and-vertigo
#12
REVIEW
C Weingart, H-J Schneider, C C Sieber
Dizziness/vertigo, falls and syncope are among the most common reasons for seeking medical care. As clinical entities they share common pathogenetic and clinical features and differences. The diagnostic work-up can often be initiated in a general practitioner's or internist's practice and, if necessary, completed in an interdisciplinary emergency unit. Simple diagnostic tools can be used in an outpatient setting to obtain valuable diagnostic information. First and foremost, it is important to differentiate between prognostically favorable clinical events and potentially serious disease...
July 17, 2017: Der Internist
https://www.readbyqxmd.com/read/28704644/amide-proton-transfer-weighted-magnetic-resonance-image-guided-stereotactic-biopsy-in-patients-with-newly-diagnosed-gliomas
#13
Shanshan Jiang, Charles G Eberhart, Yi Zhang, Hye-Young Heo, Zhibo Wen, Lindsay Blair, Huamin Qin, Michael Lim, Alfredo Quinones-Hinojosa, Jon D Weingart, Peter B Barker, Martin G Pomper, John Laterra, Peter C M van Zijl, Jaishri O Blakeley, Jinyuan Zhou
PURPOSE: Pathological assessment using World Health Organization (WHO) criteria is the gold standard for diagnosis of gliomas. However, the accuracy of diagnosis is limited by tissue sampling, particularly for infiltrating, heterogeneous tumours. We assessed the accuracy of amide proton transfer-weighted (APTw) magnetic resonance imaging (MRI)-guided tissue sampling to identify regions of high-grade glioma via radiographic-histopathologic correlation in patients with newly suspected glioma...
September 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28697253/effect-of-antidepressant-switching-vs-augmentation-on-remission-among-patients-with-major-depressive-disorder-unresponsive-to-antidepressant-treatment-the-vast-d-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Somaia Mohamed, Gary R Johnson, Peijun Chen, Paul B Hicks, Lori L Davis, Jean Yoon, Theresa C Gleason, Julia E Vertrees, Kimberly Weingart, Ilanit Tal, Alexandra Scrymgeour, David D Lawrence, Beata Planeta, Michael E Thase, Grant D Huang, Sidney Zisook, Sanjai D Rao, Patricia D Pilkinton, James A Wilcox, Ali Iranmanesh, Mamta Sapra, George Jurjus, James P Michalets, Muhammed Aslam, Thomas Beresford, Keith D Anderson, Ronald Fernando, Sriram Ramaswamy, John Kasckow, Joseph Westermeyer, Gihyun Yoon, D Cyril D'Souza, Gunnar Larson, William G Anderson, Mary Klatt, Ayman Fareed, Shabnam I Thompson, Carlos J Carrera, Solomon S Williams, Timothy M Juergens, Lawrence J Albers, Clifford S Nasdahl, Gerardo Villarreal, Julia L Winston, Cristobal A Nogues, K Ryan Connolly, Andre Tapp, Kari A Jones, Gauri Khatkhate, Sheetal Marri, Trisha Suppes, Joseph LaMotte, Robin Hurley, Aimee R Mayeda, Alexander B Niculescu, Bernard A Fischer, David J Loreck, Nicholas Rosenlicht, Steven Lieske, Mitchell S Finkel, John T Little
Importance: Less than one-third of patients with major depressive disorder (MDD) achieve remission with their first antidepressant. Objective: To determine the relative effectiveness and safety of 3 common alternate treatments for MDD. Design, Setting, and Participants: From December 2012 to May 2015, 1522 patients at 35 US Veterans Health Administration medical centers who were diagnosed with nonpsychotic MDD, unresponsive to at least 1 antidepressant course meeting minimal standards for treatment dose and duration, participated in the study...
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28670614/efficacy-and-safety-of-cold-snare-resection-in-preventive-screening-colonoscopy
#15
B Schett, J Wallner, V Weingart, A Ayvaz, U Richter, J Stahl, H-D Allescher
BACKGROUND AND AIM:  Removal of polyps during colonoscopy effectively prevents the development of colorectal cancer. So far, snare resection with high frequency current with or without prior submucosal saline injection is the method of choice. The aim of this study was to evaluate the feasibility, safety, and outcome of cold snare resection during routine endoscopy. METHODS:  In this prospective study, 522 patients undergoing outpatient colonoscopy were included...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28655713/peers-without-fears-barriers-to-effective-communication-among-primary-care-physicians-and-oncologists-about-diagnostic-delays-in-cancer
#16
Allison Lipitz-Snyderman, Minal Kale, Laura Robbins, David Pfister, Elizabeth Fortier, Valerie Pocus, Susan Chimonas, Saul N Weingart
OBJECTIVE: Relatively little attention has been devoted to the role of communication between physicians as a mechanism for individual and organisational learning about diagnostic delays. This study's objective was to elicit physicians' perceptions about and experiences with communication among physicians regarding diagnostic delays in cancer. DESIGN, SETTING, PARTICIPANTS: Qualitative analysis based on seven focus groups. Fifty-one physicians affiliated with three New York-based academic medical centres participated, with six to nine subjects per group...
November 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28647137/apneic-oxygenation-reduces-the-incidence-of-hypoxemia-during-emergency-intubation-a-systematic-review-and-meta-analysis
#17
REVIEW
Ivan Pavlov, Sofia Medrano, Scott Weingart
STUDY OBJECTIVE: Apneic oxygenation has been advocated for the prevention of hypoxemia during emergency endotracheal intubation. Because of conflicting results from recent trials, the efficacy of apneic oxygenation remains unclear. We performed a systematic review and meta-analysis to investigate the effect of apneic oxygenation on the incidence of clinically significant hypoxemia during emergency endotracheal intubation. METHODS: MEDLINE, EMBASE, and PubMed databases were searched without language and time restrictions for studies of apneic oxygenation performed in a critical care setting...
August 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28582547/the-torc1-2-inhibitor-tak228-sensitizes-atypical-teratoid-rhabdoid-tumors-to-cisplatin-induced-cytotoxicity
#18
Jeffrey A Rubens, Sabrina Z Wang, Antoinette Price, Melanie F Weingart, Sariah J Allen, Brent A Orr, Charles G Eberhart, Eric H Raabe
Background: Atypical teratoid/rhabdoid tumors (AT/RTs) are deadly pediatric brain tumors driven by LIN28. Mammalian target of rapamycin (mTOR) is activated in many deadly, drug-resistant cancers and governs important cellular functions such as metabolism and survival. LIN28 regulates mTOR in normal cells. We therefore hypothesized that mTOR is activated downstream of LIN28 in AT/RT, and the brain-penetrating mTOR complex 1 and 2 (mTORC1/2) kinase inhibitor TAK228 would reduce AT/RT tumorigenicity...
October 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28553161/presentation-of-a-method-at-the-exploration-stage-according-to-ideal-percutaneous-nephrolithotomy-pcnl-under-local-infiltrative-anesthesia-is-a-feasible-and-effective-method-retrospective-analysis-of-439-patients
#19
Thorsten H Ecke, Dimitri Barski, Guido Weingart, Carsten Lange, Steffen Hallmann, Jürgen Ruttloff, Friedhelm Wawroschek, Holger Gerullis
INTRODUCTION: This study addresses minimally invasive anesthesiologic and analgetic approaches for stone surgery in the upper urinary tract. Aim of this retrospective analysis is to compare feasibility, safety and complication rates of percutaneous nephrolithotomy (PCNL) under local infiltration anesthesia alone (Group I) and additive intravenous analgetics and/or sedative medications (Group II). MATERIAL AND METHODS: This is a single center study. A total of 439 patients have been included from November 2003 until March 2012...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28541430/implementation-and-evaluation-of-a-prototype-consumer-reporting-system-for-patient-safety-events
#20
Saul N Weingart, Joel S Weissman, Karen P Zimmer, Robert C Giannini, Denise D Quigley, Lauren E Hunter, M Susan Ridgely, Eric C Schneider
Objective: No methodologically robust system exists for capturing consumer-generated patient safety reports. To address this challenge, we developed and pilot-tested a prototype consumer reporting system for patient safety, the Health Care Safety Hotline. Design: Mixed methods evaluation. Setting: The Hotline was implemented in two US healthcare systems from 1 February 2014 through 30 June 2015. Participants: Patients, family members and caregivers associated with two US healthcare systems...
August 1, 2017: International Journal for Quality in Health Care
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