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Phase contrast Magnetic aortic

V Subramanya, B Ambale-Venkatesh, Y Ohyama, D Zhao, C C Nwabuo, W S Post, E Guallar, P Ouyang, S J Shah, M A Allison, C E Ndumele, D Vaidya, D A Bluemke, J A Lima, E D Michos
Background: Women experience a steeper decline in aortic elasticity related to aging compared to men. We examined whether sex hormone levels were associated with ascending aortic distensibility (AAD) in the Multi-Ethnic Study of Atherosclerosis. Methods: We studied 1,345 post-menopausal women and 1,532 men aged 45-84 years, who had serum sex hormone levels, AAD measured by phase-contrast cardiac magnetic resonance imaging, and ejection fraction>50% at baseline...
February 19, 2018: American Journal of Hypertension
Robert R Edelman, Ali Serhal, Amit Pursnani, Jianing Pang, Ioannis Koktzoglou
BACKGROUND: Existing cine imaging techniques rely on balanced steady-state free precession (bSSFP) or spoiled gradient-echo readouts, each of which has limitations. For instance, with bSSFP, artifacts occur from rapid through-plane flow and off-resonance effects. We hypothesized that a prototype cine technique, radial fast interrupted steady-state (FISS), could overcome these limitations. The technique was compared with standard cine bSSFP for cardiac function, coronary artery conspicuity, and aortic valve morphology...
February 19, 2018: Journal of Cardiovascular Magnetic Resonance
Romain Capoulade, Jonathan G Teoh, Philipp E Bartko, Eliza Teo, Jan-Erik Scholtz, Lionel Tastet, Mylene Shen, Christos G Mihos, Yong H Park, Julio Garcia, Eric Larose, Eric M Isselbacher, Thoralf M Sundt, Thomas E MacGillivray, Serguei Melnitchouk, Brian B Ghoshhajra, Philippe Pibarot, Judy Hung
BACKGROUND: The aim of this study was to examine the association between abnormal morphology of the proximal aorta and aortic stenosis (AS) progression rate. The main hypothesis was that morphologic changes of the proximal aorta, such as effacement of the sinotubular junction (STJ), result in increased biomechanical stresses and contribute to calcification and progression of AS. METHODS: Between 2010 and 2012, 426 patients with mild to moderate AS were included in this study...
February 16, 2018: Journal of the American Society of Echocardiography
Emile S Farag, Pim van Ooij, R Nils Planken, Kayleigh C P Dukker, Frederiek de Heer, Berto J Bouma, Danielle Robbers-Visser, Maarten Groenink, Aart J Nederveen, Bas A J M de Mol, Jolanda Kluin, S Matthijs Boekholdt
BACKGROUND: Use of 4-dimensional flow magnetic resonance imaging (4D-flow MRI) derived wall shear stress (WSS) heat maps enables identification of regions in the ascending aorta with increased WSS. These regions are subject to dysregulation of the extracellular matrix and elastic fiber degeneration, which is associated with aortic dilatation and dissection. PURPOSE: To evaluate the effect of the presence of aortic valve stenosis and the aortic diameter on the peak WSS and surface area of increased WSS in the ascending aorta...
February 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Marco Scarabello, Marina Codari, Francesco Secchi, Paola M Cannaò, Marco Alì, Giovanni Di Leo, Francesco Sardanelli
OBJECTIVES: To evaluate ascending aortic strain (AAS) with cardiac magnetic resonance (CMR) in a large consecutive series of patients with different types of cardiovascular disease (CVD). METHODS: Two-dimensional phase-contrast gradient-echo sequences of the ascending aorta were retrospectively reviewed in 1027 patients (726 males, 301 females). Aortic lumen area was segmented using a semi-automatic approach to calculate AAS values. Subgroup analysis was performed for patients with normal CMR, tetralogy of Fallot (ToF), and ischemic heart disease (IHD)...
February 2018: European Journal of Radiology
Thiago Quinaglia, Mourad Z Bensalah, Emilie Bollache, Nadjia Kachenoura, Gilles Soulat, Pierre Boutouyrie, Stéphane Laurent, Elie Mousseaux
BACKGROUND: Left ventricular (LV) remodeling and aortic stiffness have independent predictive value for all causes and cardiovascular mortality. Because elastic properties of the arterial wall vary along the aortic pathway, we hypothesized that local and regional aortic stiffness could differently impact on LV remodeling. METHODS AND RESULTS: Regional aortic stiffness was determined from carotid-femoral pulse wave velocity (cfPWV) measured by aplanation tonometry...
January 13, 2018: Journal of Hypertension
Odd Bech-Hanssen, Christian L Polte, Frida Svensson, Åse A Johnsson, Kerstin M Lagerstrand, Ulf Cederbom, Sinsia A Gao
BACKGROUND: The pulsed-wave Doppler recording in the descending aorta (PWDDAO) is one of the parameters used in grading aortic regurgitation (AR) severity. The aim of the present study was to investigate the assessment of chronic AR by PWDDAO with insights from cardiovascular magnetic resonance (CMR). METHODS: This prospective study comprised 40 patients investigated with echocardiography and CMR within 4 hours either prior to valve surgery (n = 23) or as part of their follow-up (n = 17) due to moderate or severe AR...
December 29, 2017: Journal of the American Society of Echocardiography
Hajime Abe, Nobuo Iguchi, Yuko Utanohara, Kaori Takada, Yasuki Hen, Haruhiko Machida, Norihiko Takeda, Tetsuya Sumiyoshi
Manual planimetry is a well-established method using transesophageal echocardiography (TEE) to assess the severity of aortic stenosis (AS). TEE, however, is a less than optimal approach in patients with calcified valves. Even when using cine-cardiac magnetic resonance (CMR), it is often difficult to evaluate the true border of the aortic orifice because of jet turbulence. With phase-contrast sequences of CMR, high flow signals at the aortic orifice can be clearly visualized, even in cases with severe calcification and jet turbulence...
December 27, 2017: International Heart Journal
Lior Gorodisky, Yoram Agmon, Moshe Porat, Sobhi Abadi, Jonathan Lessick
To test the feasibility of assessing mitral regurgitation (MR) severity using cardiac magnetic resonance (CMR) 4D velocity vectors to quantify regurgitant volume (RVol) by analysis of the proximal flow convergence, compared to Doppler based proximal isovelocity surface area (PISA) and CMR volume-based methods. In a prospectively designed study, 27 patients with various grades of MR underwent CMR and echo-Doppler on the same day. By CMR, multiple slices were obtained parallel to the mitral valve by phase-contrast imaging, using 3D velocity vectors, as well as short-axis cine images for left and right ventricular volume measurements...
December 19, 2017: International Journal of Cardiovascular Imaging
Yoshifumi Noda, Satoshi Goshima, Tomohiro Namimoto, Norihiro Shinkawa, Masataka Nakagawa, Kimihiro Kajita, Hiroshi Kawada, Nobuyuki Kawai, Yukichi Tanahashi, Masayuki Matsuo, Kyongtae T Bae, Toshinori Hirai, Yasuyuki Yamashita
BACKGROUND: Simultaneous acquisition of magnetic resonance angiography (MRA) and diagnostic images is challenging in contrast-enhanced upper abdominal MRI. PURPOSE: To evaluate the image quality of MRA of the abdomen acquired simultaneously with diagnostic MR images, and to compare the contrast effect, conspicuity of aortic branches, and pancreatic lesions in MRA between gadobutrol and gadoterate meglumine. STUDY TYPE: Prospective. POPULATION: Eighty-eight patients with known and suspected upper abdominal disease...
December 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
Saad Khan, Faisal Fakhouri, Waqas Majeed, Arunark Kolipaka
Cardiovascular diseases are the leading cause of death worldwide. These cardiovascular diseases are associated with mechanical changes in the myocardium and aorta. It is known that stiffness is altered in many diseases, including the spectrum of ischemia, diastolic dysfunction, hypertension and hypertrophic cardiomyopathy. In addition, the stiffness of the aortic wall is altered in multiple diseases, including hypertension, coronary artery disease and aortic aneurysm formation. For example, in diastolic dysfunction in which the ejection fraction is preserved, stiffness can potentially be an important biomarker...
November 29, 2017: NMR in Biomedicine
Li Feng, Chenchan Huang, Krishna Shanbhogue, Daniel K Sodickson, Hersh Chandarana, Ricardo Otazo
PURPOSE: To develop and evaluate a novel dynamic contrast-enhanced imaging technique called RACER-GRASP (Respiratory-weighted, Aortic Contrast Enhancement-guided and coil-unstReaking Golden-angle RAdial Sparse Parallel) MRI that extends GRASP to include automatic contrast bolus timing, respiratory motion compensation, and coil-weighted unstreaking for improved imaging performance in liver MRI. METHODS: In RACER-GRASP, aortic contrast enhancement (ACE) guided k-space sorting and respiratory-weighted sparse reconstruction are performed using aortic contrast enhancement and respiratory motion signals extracted directly from the acquired data...
November 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Ricardo A Spampinato, Cosima Jahnke, Ingo Paetsch, Sebastian Hilbert, Franziska Busch, Valerie Schloma, Yaroslava Dmitrieva, Fernanda Bonamigo Thome, Susanne Löbe, Elfriede Strotdrees, Gerhard Hindricks, Friedrich-Wilhelm Mohr, Michael A Borger
BACKGROUND: Reflux of the aortic regurgitation (AR) causes an increased diastolic reverse flow in the aorta and its branching vessels. We aimed to evaluate the feasibility and accuracy of Doppler measurements in the left subclavian artery (LSA) for quantification of AR in a cardiovascular magnetic resonance imaging (CMR) validation study. METHODS: Systolic and diastolic flow profiles of the LSA (subclavicular approach) were evaluated prospectively by use of pulsed wave Doppler in 59 patients (55...
January 2018: Journal of the American Society of Echocardiography
Marina Codari, Marco Scarabello, Francesco Secchi, Chiarella Sforza, Giuseppe Baselli, Francesco Sardanelli
PURPOSE: In this study we proposed a fully automated method for localizing and segmenting the ascending aortic lumen with phase-contrast magnetic resonance imaging (PC-MRI). MATERIAL AND METHODS: Twenty-five phase-contrast series were randomly selected out of a large population dataset of patients whose cardiac MRI examination, performed from September 2008 to October 2013, was unremarkable. The local Ethical Committee approved this retrospective study. The ascending aorta was automatically identified on each phase of the cardiac cycle using a priori knowledge of aortic geometry...
April 2018: Magnetic Resonance Imaging
Florian Joly, Gilles Soulez, Damien Garcia, Simon Lessard, Claude Kauffmann
Abdominal aortic aneurysms (AAA) are localized, commonly-occurring dilations of the aorta. When equilibrium between blood pressure (loading) and wall mechanical resistance is lost, rupture ensues, and patient death follows, if not treated immediately. Experimental and numerical analyses of flow patterns in arteries show direct correlations between wall shear stress and wall mechano-adaptation with the development of zones prone to thrombus formation. For further insights into AAA flow topology/growth interaction, a workout of patient-specific computational flow dynamics (CFD) is proposed to compute finite-time Lyapunov exponents and extract Lagrangian-coherent structures (LCS)...
November 6, 2017: Computers in Biology and Medicine
Fei Xu, Simone Morganti, Rana Zakerzadeh, David Kamensky, Ferdinando Auricchio, Alessandro Reali, Thomas J R Hughes, Michael S Sacks, Ming-Chen Hsu
Numerous studies have suggested that medical image derived computational mechanics models could be developed to reduce mortality and morbidity due to cardiovascular diseases by allowing for patient-specific surgical planning and customized medical device design. In this work, we present a novel framework for designing prosthetic heart valves using a parametric design platform and immersogeometric fluid-structure interaction (FSI) analysis. We parameterize the leaflet geometry using several key design parameters...
November 9, 2017: International Journal for Numerical Methods in Biomedical Engineering
Moritz Braig, Jochen Leupold, Marius Menza, Maximilian Russe, Cheng-Wen Ko, Juergen Hennig, Dominik von Elverfeldt
PURPOSE: Cardiovascular diseases remain the number one death cause worldwide. Preclinical 4D flow phase contrast magnetic resonance imaging can provide substantial insights in the analysis of aortic pathophysiologies in various animal models. These insights may allow a better understanding of pathophysiologies, therapy monitoring, and can possibly be translated to humans. This study provides a framework to acquire the velocity field within the aortic arch. It analyses important flow values at different locations within the aortic arch...
2017: PloS One
Volker Herold, Stefan Herz, Patrick Winter, Fabian Tobias Gutjahr, Kristina Andelovic, Wolfgang Rudolf Bauer, Peter Michael Jakob
BACKGROUND: Local aortic pulse wave velocity (PWV) is a measure for vascular stiffness and has a predictive value for cardiovascular events. Ultra high field CMR scanners allow the quantification of local PWV in mice, however these systems are yet unable to monitor the distribution of local elasticities. METHODS: In the present study we provide a new accelerated method to quantify local aortic PWV in mice with phase-contrast cardiovascular magnetic resonance imaging (PC-CMR) at 17...
October 16, 2017: Journal of Cardiovascular Magnetic Resonance
David C Wendell, Ingeborg Friehs, Margaret M Samyn, Leanne M Harmann, John F LaDisa
BACKGROUND: Children with coarctation of the aorta (CoA) can have a hyperdynamic and remodeled left ventricle (LV) from increased afterload. Literature from an experimental model suggests the putative 20 mm Hg blood pressure gradient (BPG) treatment guideline frequently implemented in CoA studies may permit irreversible vascular changes. LV remodeling from pressure overload has been studied, but data are limited following correction and using a clinically representative BPG. MATERIALS AND METHODS: Rabbits underwent CoA at 10 weeks to induce a 20 mm Hg BPG using permanent or dissolvable suture thereby replicating untreated and corrected CoA, respectively...
October 2017: Journal of Surgical Research
Matthias Dennler, Henning Richter, José Novo Matos, Marco Baron Toaldo, Ivo U Campagna, Tony M Glaus, Patrick R Kircher
OBJECTIVE To compare stroke volume (SV) calculated on the basis of cardiac morphology determined by MRI and results of phase-contrast angiography (PCA) of ventricular inflow and outflow in dogs. ANIMALS 10 healthy Beagles. PROCEDURES Cardiac MRI was performed twice on each Beagle. Cine gradient echo sequences of both ventricles in short-axis planes were used for morphological quantification of SVs by assessment of myocardial contours. From the long-axis plane, SVs in 4-chamber and left ventricular 2-chamber views were acquired at end diastole and end systole...
October 2017: American Journal of Veterinary Research
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