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Eosinophil infiltrate

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https://www.readbyqxmd.com/read/29341450/characterization-of-a-novel-papain-inducible-murine-model-of-eosinophilic-rhinosinusitis
#1
Anuj Tharakan, Alex Dobzanski, Nyall R London, Syed M Khalil, Nitya Surya, Andrew P Lane, Murugappan Ramanathan
BACKGROUND: Eosinophilic chronic rhinosinusitis (ECRS) is a disease characterized by eosinophilic inflammatory infiltrate and a local type 2 cytokine milieu. Current animal models fail to recapitulate many of the innate and adaptive immunologic hallmarks of the disease, thus hindering the development of effective therapeutics. In the present study, mice were exposed intranasally to the cysteine protease papain, which shares functional similarities with parasitic proteases and aeroallergens, to generate a rapidly inducible murine model of eosinophilic rhinosinusitis...
January 17, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29337622/isolation-of-avipoxvirus-from-tongue-of-canaries-serinus-canaria-show-severe-localized-proliferative-glossitis
#2
Salvatore Catania, Silvia Carnaccini, Marta Mainenti, Maria Luisa Moronato, Federica Gobbo, Terregino Calogero
Poxvirus was the causative agent of two unusual outbreaks of proliferative glossitis in canary ( Serinus canaria forma domestica) breeders in the Northern Italy. A total of 45, 7-9-mo-old canaries were submitted in fair postmortem conditions to the Istituto Zooprofilattico Sperimentale delle Venezie at the beginning of November 2005 for diagnostic investigation. Birds belonged to two unrelated and geographically distant aviaries in northern Italy, herein identified as Aviary A and Aviary B. The two breeder flocks had both attended the same bird exposition held at the beginning of October and started experiencing an onset of high mortality 3 wk after the show...
December 2017: Avian Diseases
https://www.readbyqxmd.com/read/29337391/time-dependent-distinct-roles-of-toll-like-receptor-4-in-a-house-dust-mite-induced-asthma-mouse-model
#3
Takashi Ishii, Yuichi Niikura, Keigo Kurata, Masashi Muroi, Ken-Ichi Tanamoto, Takahide Nagase, Masahiro Sakaguchi, Naomi Yamashita
House dust mites (HDMs) are a common source of allergens that trigger both allergen-specific and innate immune responses in humans. Here we examined the effect of allergen concentration and the involvement of Toll-like receptor 4 (TLR4) in the process of sensitization to house dust mite allergens in an HDM-extract-induced asthma mouse model. Intranasal administration of HDM extract induced an immunoglobulin E response and eosinophilic inflammation in a dose-dependent manner from 2.5 to 30 μg/dose. In TLR4-knockout mice, the infiltration of eosinophils and neutrophils into the lung was decreased compared with that in wild-type mice in the early phase of inflammation (total of three doses)...
January 16, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29336433/eosinophilic-esophagitis-relationship-of-subepithelial-eosinophilic-inflammation-with-epithelial-histology-endoscopy-blood-eosinophils-and-symptoms
#4
Alain M Schoepfer, Audrey Simko, Christian Bussmann, Ekaterina Safroneeva, Marcel Zwahlen, Thomas Greuter, Luc Biedermann, Stephan Vavricka, Sébastien Godat, Antoine Reinhard, Catherine Saner, Hugo Maye, Christine Sempoux, Christophe Brunel, Carine Blanchard, Dagmar Simon, Hans-Uwe Simon, Alex Straumann
OBJECTIVES: For technical reasons, the histologic characterization of eosinophilic esophagitis (EoE)-specific alterations is almost exclusively based on those found in the esophageal epithelium, whereas little is known about subepithelial abnormalities. In this study, we aimed to systematically assess the nature of subepithelial histologic alterations, and analyze their relationship with epithelial histologic findings, endoscopic features, and symptoms. METHODS: Adult patients with established EoE diagnosis were prospectively included during a yearly follow-up visit...
January 16, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29331794/melatonin-suppresses-eosinophils-and-th17-cells-in-hamsters-treated-with-a-combination-of-human-liver-fluke-infection-and-a-chemical-carcinogen
#5
Wachanan Wongsena, Lakhanawan Charoensuk, Rungtiwa Dangtakot, Porntip Pinlaor, Kitti Intuyod, Somchai Pinlaor
BACKGROUND: The combination of Opisthorchis viverrini (OV) infection and chemical carcinogen induces cholangiocarcinoma (CCA) in hamsters via inflammation-mediated mechanisms. Thus, suppression of inflammatory cells at the initial stages of CCA development would be of benefit. We aimed to investigate whether IL-17-producing CD4+ T cells (Th17) and CD4+ Foxp3+ T cells (Treg) are involved in the early stages of CCA genesis and can be targeted for suppression by melatonin. METHODS: Inflammation, an initial stage of CCA development, was induced in hamsters by a combination of O...
July 26, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29324473/chondromyxoid-fibroma-arising-in-craniofacial-sites-a-clinicopathologic-analysis-of-25-cases
#6
David M Meredith, Christopher D M Fletcher, Vickie Y Jo
Chondromyxoid fibroma (CMF) is a rare benign tumor, usually arising in the metaphysis of long bones in young adults. Occurrence in craniofacial bones presents a particular diagnostic challenge given its unusual location and resemblance to malignant mimics. We describe the clinicopathologic features of 25 cases of craniofacial CMF identified between 1999 and 2017. Patients were 14 men and 11 women, with median age of 44 years (range, 5 to 83 y). Sites of involvement were sphenoid (7), ethmoid (5), maxilla (3), occipital (2), nasal septum (2), palatine (2), temporal (2), orbit (1), and undisclosed skull (1)...
January 10, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29317890/enterobius-vermicularis-in-the-endometrium-of-the-uterus-a-case-report
#7
Biserka Pigac, Silvija Mašić, Valentina Mašić
Enterobius vermicularis is an intestinal nematode of humans and the most common helminth infection. Main transmission path is direct contact between infected and uninfected person meaning ingestion of the eggs. Human infections are usually asymptomatic or manifest as perianal itching. Although ectopic locations are uncommon, Enterobius can occasionally be detected in appendix, kidney, male urinary tract and female genital tract. We present a case from Varaždin General Hospital, Varaždin, Croatia in 2012, involving a 90-yr-old female patient who underwent hysterectomy leading to accidental finding of E...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29312868/aortic-stiffness-is-increased-in-patients-with-hypereosinophilic-syndrome-being-in-early-necrotic-phase
#8
Attila Nemes, Imelda Marton, Péter Domsik, Anita Kalapos, Éva Pósfai, Szabolcs Modok, Zita Borbényi, Tamás Forster
Background: Persistent eosinophilia and eosinophil-mediated single- or multiple-organ damage are typical features of hypereosinophilic syndrome (HES). Theoretically, eosinophilic infiltration of the ascending aortic wall could not be excluded in HES, therefore the present study aimed to test whether HES is associated with abnormalities in aortic elastic properties. Methods: The present study comprised 10 HES patients (mean age: 57.6±10.1 years, 5 males) without known cardiovascular disease, their results were compared to 19 age-, gender- and risk factor-matched controls (59...
December 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29312537/lipopolysaccharide-induces-acute-bursal-atrophy-in-broiler-chicks-by-activating-tlr4-mapk-nf-%C3%AE%C2%BAb-ap-1-signaling
#9
Abdur Rahman Ansari, Ning-Ya Li, Zhi-Jian Sun, Hai-Bo Huang, Xing Zhao, Lei Cui, Ya-Fang Hu, Ju-Ming Zhong, Niel A Karrow, Hua-Zhen Liu
We investigated the mechanisms that induce atrophy of the chicken bursa of Fabricius (BF) upon lipopolysaccharide (LPS) treatment in young chicks. LPS treatment resulted in ∼36% decrease in bursal weight within 36 h (P < 0.01). Histological analysis showed infiltration of eosinophilic heterophils and nucleated oval shaped RBCs in or near blood vessels of the BF from LPS-treated chicks. Scanning electron micrographs showed severe erosion and breaks in the mucosal membrane at 12 h and complete exuviation of bursal mucosal epithelial cells at 36 h...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29302215/inhibitory-effects-of-2-6-di-tert-butyl-4-hydroxymethylphenol-on-asthmatic-responses-to-ovalbumin-challenge-in-conscious-guinea-pigs
#10
Seul-Yong Jeong, Ji-Yun Lee
This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining the specific airway resistance (sRaw) and tidal volume (TV) during the immediate asthmatic response (IAR) and the late-phase asthmatic response (LAR) in guinea pigs with aerosolized ovalbumin-induced asthma. Recruitment of leukocytes and the levels of biochemical inflammatory mediators were determined in the bronchoalveolar lavage fluids (BALFs), and histopathological surveys performed in lung tissues...
January 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29296203/the-pathogenesis-of-diclofenac-induced-immunoallergic-hepatitis-in-a-canine-model-of-liver-injury
#11
Saravanakumar Selvaraj, Jung-Hwa Oh, Reinhard Spanel, Florian Länger, Hyoung-Yun Han, Eun-Hee Lee, Seokjoo Yoon, Jürgen Borlak
Hypersensitivity to non-steroidal anti-inflammatory drugs is a common adverse drug reaction and may result in serious inflammatory reactions of the liver. To investigate mechanism of immunoallergic hepatitis beagle dogs were given 1 or 3 mg/kg/day (HD) oral diclofenac for 28 days. HD diclofenac treatment caused liver function test abnormalities, reduced haematocrit and haemoglobin but induced reticulocyte, WBC, platelet, neutrophil and eosinophil counts. Histopathology evidenced hepatic steatosis and glycogen depletion, apoptosis, acute lobular hepatitis, granulomas and mastocytosis...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290036/eosinophilic-esophagitis-clinical-manifestations-and-differential-diagnosis
#12
REVIEW
Diana Muñoz-Mendoza, Adrián Chapa-Rodríguez, Sami L Bahna
As a chronic inflammatory disease with eosinophilic infiltrate of the esophagus, eosinophilic esophagitis (EoE) causes a variety of gastrointestinal (GI) clinical manifestations. None of the symptoms, endoscopic features, or biopsy findings is pathognomonic of the disease, even with high degrees of esophageal eosinophilia. The pathogenesis has been explored by several studies, yet it still far from being completely understood. Evidence supports a role of allergen-driven Th2 lymphocyte mechanism, though not in every patient...
December 30, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29279552/nephrotic-syndrome-during-the-tapering-of-oral-steroids-after-pathological-diagnosis-of-kimura-disease-from-a-lacrimal-gland-mass-case-report-and-review-of-10-japanese-patients
#13
Toshihiko Matsuo, Takehiro Tanaka, Masaru Kinomura
A 42-year-old man with eosinophilia and high serum immunoglobulin E (IgE) developed a lacrimal gland mass on the left side. Excisional biopsy revealed hyperplasia of lymphoid follicles, and infiltration with lymphocytes and eosinophils around lacrimal gland acini, leading to the pathological diagnosis of Kimura disease. IgE-positive cells were mainly found along follicular dendritic cells, and a small number of IgG4-positive cells was present. One month after oral prednisolone was started at 40 mg daily and tapered to 10 mg daily, he developed lower leg edema on both sides and marked proteinuria (10...
2017: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/29278941/characteristics-of-lower-airway-inflammatory-changes-in-the-minimal-persistent-inflammation-of-allergic-rhinitis-in-mice
#14
Jie Xu, Li Gao, Hongbing Yao, Rong Zhang, Na Liu, Lijia Wang, Enmei Liu, Jihong Dai, Zhou Fu
OBJECTIVE: This study aims to establish an experimental mouse model of minimal persistent inflammation (MPI), observe the features of inflammation and hyper-responsiveness of the upper/lower airways, and explore the relationship between inflammation and hyper-responsiveness in the upper/lower airways. METHODS: Sixty-four female BALB/c mice were randomly divided into four groups: allergic rhinitis (AR) group as positive control, MPI group, negative control group and blank control group...
December 26, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29278655/eosinophilic-esophagitis-in-japan-focus-on-response-to-acid-suppressive-therapy
#15
REVIEW
Norihisa Ishimura, Yoshikazu Kinoshita
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition characterized by esophageal dysfunction and dense eosinophilic infiltration of esophageal epithelium. According to clinical consensus and guidelines published in 2011, esophageal eosinophilia was classified into 2 entities based on response to proton pump inhibitor (PPI) administration; EoE and PPI-responsive esophageal eosinophilia (PPI-REE). We have performed a series of investigations to determine whether EoE is actually different from PPI-REE...
December 26, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29275304/preventive-effects-of-vitamin-c-on-diethylnitrosamine-induced-hepatotoxicity-in-smp30-knockout-mice
#16
Young-Sook Son, H M Arif Ullah, Ahmed K Elfadl, Myung-Jin Chung, Soong-Gu Ghim, Yong Deuk Kim, Eun-Joo Lee, Kyung-Ku Kang, Kyu-Shik Jeong
Vitamin C (L-ascorbic acid) is well known as a free radical scavenger that protects cells against damage from oxidative stress. Herein, we investigated the effects of vitamin C against diethylnitrosamine (DEN)-induced hepatotoxicity. Male wild-type (C57BL/6) and senescence marker protein-30 (Smp30) knockout (KO) mice were used and divided in the following four groups: WT group (n=15): Wild-type (WT) mice fed vitamin C-free diet with tap water; WV group (n=14): WT mice fed vitamin C-free diet with water supplemented with 1...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29274041/intraoral-pigmented-low-grade-adenocarcinoma-not-otherwise-specified-case-report-and-immunohistochemical-study
#17
Jessica Luana Dos Santos, Albina Messias de Almeida Milani Altemani, Alexandre Elias Trivellato, Cássio Edvard Sverzut, Luciana Yamamoto Almeida, Lucas Ribeiro Teixeira, Alfredo Ribeiro-Silva, Jorge Esquiche León
Salivary adenocarcinoma, not otherwise specified (AdCaNOS) is a rare malignant tumor with potential diagnostic challenge, which mainly affects the parotid glands; however, the minor salivary glands can also be involved by AdCaNOS. This paper reports a case of a 45-year-old Afro-descendant woman complaining of a slow-growing mass with 6 months of evolution in the left superior vestibular fornix. Microscopic examination revealed an infiltrative epithelial neoplasm composed of predominantly solid growth pattern, arranged in a lobular configuration, admixed with glandular or ductal structures...
December 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29273488/repeated-amblyomma-testudinarium-tick-bites-are-associated-with-elevated-anti-galactose-%C3%AE-1-3-galactose-carbohydrate-ige-antibody-levels-a-retrospective-cohort-study-in-a-single-institute
#18
Hideo Hashizume, Toshiharu Fujiyama, Takatsune Umayahara, Reiko Kageyama, Andrew F Walls, Takahiro Satoh
BACKGROUND: Alpha gal syndrome is a hypersensitivity reaction to red meat mediated by specific IgE antibody to galactose-α-1,3-galactose carbohydrate (alpha gal). Amblyomma tick bites are associated with this condition although the pathophysiology is not understood. OBJECTIVE: To clarify the mechanism of development of alpha gal syndrome after tick bites. METHODS: We compared alpha gal antibodies between patients with and without a history of tick bites and examined the histology of tick bite lesions between patients with and without detectable anti-alpha-gal IgE antibody...
December 19, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29261008/the-medicinal-mushroom-grifola-gargal-ameliorates-allergic-bronchial-asthma
#19
Etsuko Harada, Corina N D'Alessandro-Gabazza, Masaaki Toda, Toshihiro Morizono, Toshiaki Totoki, Taro Yasuma, Kota Nishihama, Tetsu Kobayashi, Toshimitsu Sumiya, Hirokazu Kawagishi, Esteban C Gabazza
Grifola gargal Singer, a medicinal mushroom, has been found to be effective for the prevention and treatment of various chronic inflammatory diseases. However, the effects of G. gargal on allergic diseases are unknown. The present study investigated the effect of G. gargal extract on allergic bronchial asthma. Asthma was induced in mice by ovalbumin sensitization and inhalation. The grade of asthma was compared between mice fed with chow containing G. gargal extract and mice given standard chow. The human mast cell and eosinophilic cell lines were used for in vitro studies...
December 20, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29259861/inflammatory-fibroid-polyp-of-the-gastric-antrum-presenting-as-hypovolemic-shock-case-report-and-literature-review
#20
Kyle D Klingbeil, Alexandra Balaban, Raymond M Fertig, A Caresse Gamret, Yuna Gong, Carolyn Torres, Shevonne S Satahoo
Inflammatory fibroid polyps (IFP) are an extremely rare entity that arise within the submucosa of the gastrointestinal tract, and represent less than 0.1% of all gastric polyps. They are most commonly localized to the gastric antrum, small intestines and recto-sigmoid colon. IFPs are most commonly found incidentally upon endoscopic evaluation in the absence of symptoms. Presenting symptoms depend on the location of the tumor, although polyps located in the stomach most commonly present with epigastric pain and early satiety...
November 2017: Intractable & Rare Diseases Research
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