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Eosinophil infiltrate

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https://www.readbyqxmd.com/read/29165413/-ophthalmoferon-efficacy-in-the-treatment-of-children-with-chronic-blepharoconjunctivitis
#1
L P Prozornaya, V V Brzheskiy
AIM: To study possibilities of using the medication Ophthalmoferon in the treatment of children with chronic allergic and Demodex blepharoconjunctivitis. MATERIAL AND METHODS: We examined 40 children (80 eyes) aged 3 to 17 years with chronic allergic (group I) and Demodex (group II) blepharoconjunctivitis. Each group was divided into two subgroups ('A' and 'B') respectively based on the treatment regimen used. Subgroup 'A' patients received Ophtalmoferon instillations (four times per day for four weeks) in addition to the standard therapy, whereas subgroup 'B' patients got only basic treatment of blepharoconjunctivitis...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29161525/sea-cucumber-lipid-soluble-extra-fraction-prevents-ovalbumin-induced-allergic-airway-inflammation
#2
Da-In Lee, Shin Ae Kang, Anisuzzaman Md, U-Cheol Jeong, Feng Jin, Seok-Joong Kang, Jeong-Yeol Lee, Hak Sun Yu
In a previous study, our research group demonstrated that sea cucumber (Apostichopus japonicus) extracts ameliorated allergic airway inflammation through CD4(+)CD25(+)Foxp3(+) T (regulatory T; Treg) cell activation and recruitment to the lung. In this study, we aimed to determine which components of sea cucumber contribute to the amelioration of airway inflammation. We used n-hexane fractionation to separate sea cucumber into three phases (n-hexane, alcohol, and solid) and evaluated the ability of each phase to elevate Il10 expression in splenocytes and ameliorate symptoms in mice with ovalbumin (OVA)/alum-induced asthma...
November 21, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29159033/interstitial-pneumonia-caused-by-dabigatran
#3
Toyoshi Yanagihara, Norio Yamamoto, Yasuaki Kotetsu, Naoki Hamada, Eiji Harada, Kunihiro Suzuki, Kayo Ijichi, Yoshinao Oda, Yoichi Nakanishi
We describe the case of a 73-year-old man who experienced dry cough and exertional dyspnea after dabigatran administration. Chest radiographs revealed the development of bilateral consolidative and ground glass opacity, and transbronchial lung biopsy showed organized materials in the alveolar spaces with moderate inflammatory infiltrate and focal fibrosis. Lung opacity gradually disappeared after discontinuing dabigatran. To date, there has been only one report regarding dabigatran-induced lung injury, except for alveolar hemorrhage and eosinophilic pneumonia...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29158145/intratumoural-leukocyte-infiltration-is-a-prognostic-indicator-among-pancreatic-cancer-patients-with-type-2-diabetes
#4
Emelie Karnevi, Agata Sasor, Katarzyna Said Hilmersson, Daniel Ansari, Jonas S Erjefält, Ann H Rosendahl, Roland Andersson
BACKGROUND: The life expectancy of pancreatic cancer patients remains minimal. The disease progression may be influenced by type 2 diabetes (T2D) and inflammatory status, although important gaps persist around their joint effects on disease outcome. The aim of this study was to investigate the clinical significance of the tumour immune microenvironment on pancreatic cancer prognosis in relation to T2D status. METHOD: Tumour-infiltrating macrophages, neutrophils and eosinophils were studied in primary pancreatic tumours and paired lymph node metastases in relation to patient and tumour characteristics, T2D status and overall survival in a retrospective cohort of patients with resectable pancreatic cancer in Sweden...
November 11, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29151479/a-case-of-loeffler-endocarditis-that-showed-endomyocardial-systolic-dysfunction-detected-by-layer-specific-strain-analysis
#5
Xuanyi Jin, Chunyan Ma, Yonghuai Wang, Jun Yang
Loeffler endocarditis is a rare comprehensive cardiac manifestation caused by eosinophilic cell infiltrations and is present in 50%-60% of patients with hypereosinophilic syndrome (HES). Left ventricle (LV) endocardial systolic dysfunction is a major cause of morbidity and mortality in HES and Loeffler endocarditis. We present a case of Loeffler endocarditis, whose left ventricular (LV) systolic dysfunction and endocardial systolic dysfunction were first neglected by conventional transthoracic echocardiography (TTE), but were later pointed out by layer-specific longitudinal strain analysis...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29146059/oral-lymphomatoid-papulosis-type-c-a-diagnostic-pitfall-often-confused-with-t-cell-lymphoma
#6
Ziv Schwartz, Morton Coleman, Jennifer P Toyohara, Paul D Freedman, Cynthia M Magro
Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. The pathogenesis of the condition is unclear, although reports dating back to 1997 suggest that at least a subset of EUOM represents CD30 positive lymphoproliferative disorder (CD30+ LPD)...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29145901/-food-bolus-obstruction-of-the-oesophagus-or-ingestion-of-a-foreign-body-what-should-you-do
#7
P R Oosterwijk, M A C Meijssen
A food bolus obstruction of the oesophagus and foreign body ingestion are frequently encountered in common clinical practice. There is currently no guideline in the Netherlands for management of these problems. We present two cases to illustrate how these can be managed in line with European and American guidelines. The first patient was a 36-year-old female with total obstruction of the oesophagus by a food bolus. Biopsies taken following endoscopic removal showed eosinophilic infiltration of the mucosa and a subsequent diagnosis of eosinophilic oesophagitis...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29141745/histology-and-serum-cytokine-responses-in-an-imported-rickettsia-slovaca-infection-germany
#8
Dennis Tappe, Nina Booken, Almut Böer-Auer, Jessica Rauch, Stefan Schmiedel, Kristian Reich
Rickettsia slovaca, a spotted fever group rickettsial pathogen, causes a syndrome consisting of scalp eschar and neck lymphadenopathy following tick bites. We analyzed the histologic skin reaction in the eschar, showing a prominent eosinophilic infiltration, as well as the presence of B lymphocytes and CD4- and CD8-positive T cells. Examination of the serum cytokine responses over time demonstrated an initial proinflammatory cytokine elevation followed by normalization.
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140397/progress-in-the-understanding-of-the-pathology-of-allergic-asthma-and-the-potential-of-fruit-proanthocyanidins-as-modulators-of-airway-inflammation
#9
REVIEW
Sara L Coleman, Odette M Shaw
Allergic asthma is a chronic inflammatory lung disease characterized by sensitization of the airways, and the development of immunoglobulin E antibodies, to benign antigens. The established pathophysiology of asthma includes recurrent lung epithelial inflammation, excessive mucus production, bronchial smooth muscle hyperreactivity, and chronic lung tissue remodeling, resulting in reversible airflow restriction. Immune cells, including eosinophils and the recently characterized type 2 innate lymphoid cells, infiltrate into the lung tissue as part of the inflammatory response in allergic asthma...
November 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29137646/the-potential-of-interleukin-37-as-an-effective-therapeutic-agent-in-asthma
#10
REVIEW
Lina Zhang, Jie Zhang, Peng Gao
Interleukin (IL)-37 belongs to the IL-1 cytokine family. It binds to IL-18Rα and recruits the orphan decoy IL-1R8. Emerging evidence shows that IL-37 is a key player in the regulation of inflammation, cellular differentiation, and proliferation. Altered IL-37 expression has been demonstrated in many inflammatory disease conditions, including asthma. In rheumatoid arthritis, IL-37 is involved in the regulation of proliferation, production of inflammatory mediators, and activation of inflammatory cells. Furthermore, this cytokine acts as a negative regulator of inflammation in inflammatory bowel disease...
November 14, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29129299/endoscopic-and-radiologic-findings-in-eosinophilic-esophagitis
#11
REVIEW
Jeffrey A Alexander
Eosinophilic esophagitis (EoE) was first described by Landis in 1978. The disease is characterized by esophageal symptoms, primarily dysphagia in adult patients, and esophageal eosinophilic infiltration. The disease is associated with characteristic endoscopic findings, including edema, rings, furrows, exudates, and strictures. The typical radiographic findings of this disorder are rings, strictures, and small-caliber esophagus. The endoscopic and radiographic findings of EoE are the topic of this review.
January 2018: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/29129297/demographic-features-of-eosinophilic-esophagitis
#12
REVIEW
Anna Maria Lipowska, Robert T Kavitt
Eosinophilic esophagitis (EoE) is an increasingly prevalent chronic condition characterized by eosinophilic infiltration of the esophageal epithelium accompanied by esophageal symptoms. The number of new diagnoses is growing worldwide in both pediatric and adult populations. Differences in disease distribution and presentation have been found, varying by gender, race, and other characteristics. This review examines the existing literature and provides insight into the demographic features of EoE.
January 2018: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/29127573/eosinophilic-granulomatosis-with-polyangiitis-complicated-by-subarachnoid-hemorrhage-and-coronary-vasculitis-a-case-report-and-review-of-the-literature
#13
REVIEW
Shogo Matsuda, Shuzo Yoshida, Youhei Fujiki, Hidetoshi Satomi, Tohru Takeuchi, Yoshinobu Hirose, Shigeki Makino, Shigeki Arawaka
Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by necrotizing vasculitis of small-sized vessels with extravascular granulomas and eosinophilic infiltration. The case of a 48-year-old Japanese woman with EGPA, who presented concurrently with subarachnoid hemorrhage (SAH) and coronary vasculitis, is reported. She initially presented with bronchial asthma, and then 8 months later she developed various symptoms caused by systemic eosinophilic vasculitis and was admitted to our hospital. Three days after admission, she started oral corticosteroid therapy, and her 2009 Five-Factor Score (FFS) was 0...
November 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29127130/eosinophilic-oesophagitis-and-coeliac-disease-is-there-an-association
#14
Ana Margarida Vaz, Antonio Jesus Cadilla, Diamantino Sousa, Horácio Guerreiro
A 25-year-old man was seen in outpatient clinic for progressive solid food dysphagia. He was already medicated with a proton pump inhibitor with no improvement. His blood tests showed a slight microcytic anaemia and peripheral eosinophilia. The oesophago-gastro-duodenoscopy showed longitudinal furrows in the distal two-thirds of the oesophagus and a concentric distal stenosis. The biopsies taken showed eosinophilic infiltrates consistent with eosinophilic oesophagitis. There was no improvement with topical fluticasone, so the patient was started on a systemic corticosteroid with resolution of dysphagia and of the oesophageal stenosis...
November 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29115454/mycoleptodonoides%C3%A2-aitchisonii-suppresses-asthma-via-th2-and-th1-cell-regulation-in-an-ovalbumin%C3%A2-induced-asthma-mouse-model
#15
Soon-Young Lee, Chun-Sik Bae, Ji-Hye Seo, Seung Sik Cho, Min-Suk Bae, Deuk-Sil Oh, Dae-Hun Park
Asthma is a chronic respiratory disease related to hyper‑responsiveness. The majority of patients suffer mild symptoms, however, some cases, especially in the young and the elderly, can lead to death by apnea. Mycoleptodonoides atichisonii (M. atichisonii) is an edible mushroom that has previously been reported to possess several bioactive properties, such as the synthesis of nerve growth factors, anti‑obesity effects and the ability to prevent cell death. In the current study, the authors evaluated the anti‑asthmatic effects of M...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114121/pathological-studies-on-helminth-parasitic-infection-in-mithun-bos-frontalis
#16
J K Chamuah, B Dutta, D Borkotoky
A pathological study was carried out in different helminth parasite infection organs in 110 animals during the period from 2010 to 2016. Histopathological examination of hydatid cysts in the liver, showed extensive fibrous connective tissue proliferation with eosinophilic and lymphocytic infiltration, in lung, parenchyma showed severe emphysema with infiltration of alveolar macrophages and lymphocytes infiltration. In Toxocara infection, polymorphonuclear infiltration in the sub-mucosa with hyper activity of goblet cells leading to occlusion of the gland was noted in the tissue sections...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29105783/clinical-implications-of-mast-cell-involvement-in-allergic-conjunctivitis
#17
REVIEW
D Elieh Ali Komi, T Rambasek, L Bielory
The conjunctiva is a common site for the allergic inflammatory response due to it being highly vascularized, having constant exposure to environmental pollutants and allergenic pollens and having a unique conjunctival associated lymphoid tissue. The primary morbidity of anterior surface conjunctival disorders that include allergic conjunctivitis and tear film disorders is associated with its high frequency of involvement rather than its severity, although the more chronic forms can involve the cornea and lead to sight-threatening conditions...
November 6, 2017: Allergy
https://www.readbyqxmd.com/read/29105198/braf-v600e-tert-promoter-mutations-and-cdkn2a-b-homozygous-deletions-are-frequent-in-epithelioid-glioblastomas-a-histological-and-molecular-analysis-focusing-on-intratumoral-heterogeneity
#18
Nozomi Nakajima, Sumihito Nobusawa, Satoshi Nakata, Mitsutoshi Nakada, Tatsuya Yamazaki, Nozomi Matsumura, Kenichi Harada, Hadzki Matsuda, Nobuaki Funata, Shoichi Nagai, Hideo Nakamura, Atsushi Sasaki, Jiro Akimoto, Junko Hirato, Hideaki Yokoo
Epithelioid glioblastoma (E-GBM) is a rare aggressive variant of IDH-wildtype glioblastoma newly recognized in the 2016 World Health Organization classification, composed predominantly of monotonous, patternless sheets of round cells with laterally positioned nuclei and plump eosinophilic cytoplasm. Approximately 50% of E-GBM harbor BRAF V600E, which is much less frequently found in other types of glioblastomas. Most E-GBM are recognized as primary/de novo lesions; however, several E-GBM with co- or pre-existing lower-grade lesions have been reported...
November 4, 2017: Brain Pathology
https://www.readbyqxmd.com/read/29104849/current-concepts-in-eosinophilic-esophagitis
#19
REVIEW
Dagmar Simon, Alex Straumann, Alain M Schoepfer, Hans-Uwe Simon
Background: Eosinophilic esophagitis (EoE) is a disease entity first described in the 1990s, but showing an increasing incidence that is characterized clinically by esophageal dysfunction and histologically by a striking eosinophil infiltration. Methods: This article discusses new aspects of the pathogenesis, symptoms, diagnosis, and treatment of EoE. Results: EoE affects both children and adults and is frequently associated with atopic disease and IgE sensitization...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/29099969/anti-tumor-immunity-via-the-superoxide-eosinophil-axis-induced-by-a-lipophilic-component-of-mycobacterium-lipomannan
#20
Toshihiro Ito, Kiyoshi Hirahara, Atsushi Onodera, Ryo Koyama-Nasu, Ikuya Yano, Toshinori Nakayama
Mycobacterium bovis Bacille Calmette-Guérin (BCG) has been shown to possess potent anti-tumor activity particularly in various animal models, while the cellular and molecular mechanisms underlying its activity are not well understood. We found that lipomannan (BCG-LM), a lipophilic component of the mycobacterial cell envelope, specifically inhibits tumor growth and induces the infiltration of eosinophils at local tumor invasion sites. In contrast, neither lipoarabinomannan (BCG-LAM) nor the cell wall of Mycobacterium bovis BCG (BCG-CW) exerted anti-tumor immunity...
November 1, 2017: International Immunology
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