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JOURNAL ARTICLE
Hong Pil Hwang, Kyoung Min Kim, Hyojin Han, Jeong-Hwan Hwang
BACKGROUND: Scrub typhus, an acute febrile disease with mild to severe, life-threatening manifestations, potentially presents with a variety of complications, including pneumonia, acute respiratory distress syndrome, cardiac arrhythmias (such as atrial fibrillation), myocarditis, shock, peptic ulcer, gastrointestinal bleeding, meningitis, encephalitis, and renal failure. Of the various complications associated with scrub typhus, splenic rupture has rarely been reported, and its mechanisms are unknown...
January 22, 2024: Infectious Diseases of Poverty
#2
Larua Londono, Michael Makutonin, Anthony Dure, Justin Canakis, Luis W Dominguez
A 54-year-old man with a history of hypertension, atrial fibrillation, chronic kidney disease, nonischemic cardiomyopathy, osteoarthritis, and gout presented to the emergency department (ED) with dysuria, painful scrotal swelling, severe bilateral flank pain, back pain, atraumatic right arm (elbow and distally) pain and swelling, and bilateral knee pain. His physical exam was notable for fever, tachycardia, bilateral costovertebral angle (CVA) tenderness, exquisite pain, erythema, and swelling of bilateral knees and the right arm (elbow and distally)...
October 2023: Curēus
#3
JOURNAL ARTICLE
Pradeep Kumar Gunasekaran, Devika Shanmugasundaram, Sridhar Santhanam, Sanjay Verma, Kuldeep Singh, Bhagirathi Dwibedi, Shally Awasthi, Himabindu Singh, Mahantesh Sangappa, Nivedita Mondal, Priya Sreenivasan, Geetha Saradakutty, Shikha Malik, Manish Jain, Rajlakshmi Viswanathan, Gajanan Sapkal, Shalini Tripathi, Bhupeshwari Patel, Mahendra Kumar Jain, Sanjeev Hanumantacharya Naganur, Arun Baranwal, Manoj K Rohit, Surender Deora, Akhil Sharma, Avinash Anantharaj, Lakshmi Sadasivan Pillai, Amber Kumar, Sabarinathan Ramasamy, Padma Priya Rajendran, Mini P Singh, Radha Kanta Ratho, Vijaylakshmi Nag, Ravishekhar Gadepalli, Baijayantimala Mishra, Tapas Kumar Som, Amita Jain, Sudha Madhuri Devara, Sudha Rani Vannavada, Ashok Munivenkatappa, Asha Mary Abraham, Rahul Dhodapkar, Syed Ali, Debasis Biswas, Deepashri Pratkeye, Ashish Bavdekar, Jayant Prakash, Jaydeb Ray, Manoj Murhekar
BACKGROUND: The phenotypical profile of cardiovascular malformations in patients with congenital rubella syndrome (CRS) is varied. We aimed to describe the profile of cardiac defects among CRS patients detected in the sentinel CRS surveillance in India during 2016-22. METHODS: Sentinel sites enrolled infants with suspected CRS based on presence of cardiac defects, hearing impairment, eye signs, or maternal history of febrile rash illness. Suspected CRS cases underwent detailed systemic examination, including echocardiography and serological investigation for rubella...
September 2023: Lancet Reg Health Southeast Asia
#4
Judah A Kreinbrook, Annalia Foster, Luis Paulino, Fabio Leonelli
COVID-19 has been associated with an increased risk of both atrial and ventricular arrhythmias. Brugada syndrome (BrS), an inherited sodium channelopathy presenting with a characteristic ECG morphology, confers a baseline risk of ventricular arrhythmias such as ventricular fibrillation (VF), especially during febrile illnesses. However, mimics of BrS, termed Brugada phenocopies (BrP), have been noted in association with fever, electrolyte abnormalities, and toxidromes outside of viral illness. Such presentations manifest the same ECG pattern, the type-I Brugada pattern (type-I BP)...
April 2023: Curēus
#5
JOURNAL ARTICLE
Marie Jarolímová, Michal Kazmíř
Hyperthyreoidism is a clinical manifestation of excessive production of thyroid hormones. In most cases pacient ´s condition allows ambulant treatment. Rarely, it can develop into an acute, life- threatening thyrotoxic crisis which has to be treated in the intensive care unit. Main therapy includes antithyroid medication, corticosteroids, beta- blockers and rehydratation, mostly parenteral. If initial treatment fails, plasmapheresis provides effective strategy. Antithyroid medication may come with side effects as rash, digestive issues, joint pain...
2023: Vnitr̆ní Lékar̆ství
#6
JOURNAL ARTICLE
Sarah Burgess
A 76-year-old lady was found on the floor following a fall at home. She was uninjured, but unable to get up, and had been lying on the floor for roughly 18 hours before her son arrived. She had been unwell for the past 3 days with a cough and shortness of breath. She had a past medical history of diabetes, hypertension, hypercholesterolaemia and atrial fibrillation (AF). On examination, she was alert but distressed, clinically dehydrated, febrile and tachycardic. She was treated for community acquired pneumonia with co-amoxiclav and was fluid resuscitated with Hartmann's solution...
November 2022: Journal of the Intensive Care Society
#7
JOURNAL ARTICLE
Jordan Hall, Melanie Rosado, Julie D Wohrley, Sindhura Bandi, Paul M Kent, Sara E Jandeska, Joshua Murphy, Marylouise K Wilkerson
A 10-year-old male with a past medical history of premature pubarche, mild persistent asthma, and eczema presented to the emergency department with progressive dyspnea and chest pain. On examination, he was found to be tachycardic and tachypneic. Chest radiograph demonstrated cardiomegaly, bilateral pleural effusions, and scattered atelectasis. Echocardiogram revealed a large pericardial effusion with right atrial collapse. The patient was admitted to the pediatric ICU for pericardiocentesis and drain placement...
January 1, 2023: Pediatrics
#8
JOURNAL ARTICLE
Mazyar Shadman, Ian W Flinn, Moshe Y Levy, Ryan F Porter, John M Burke, Syed F Zafar, Jamal Misleh, Edwin C Kingsley, Habte A Yimer, Benjamin Freeman, Subramanya S Rao, Arvind Chaudhry, Praveen K Tumula, Mitul D Gandhi, Sudhir Manda, Dih-Yih Chen, Kunthel By, Linlin Xu, Ye Liu, Rocco Crescenzo, Adam Idoine, Xiaoping Zhang, Aileen Cohen, Jane Huang, Jeff P Sharman
BACKGROUND: We hypothesised that zanubrutinib, a highly selective next-generation Bruton tyrosine kinase (BTK) inhibitor, would be a safe and active treatment for patients intolerant of ibrutinib, acalabrutinib, or both. We aimed to assess whether zanubrutinib would prolong treatment duration by minimising treatment-related toxicities and discontinuations in patients with previously treated B-cell malignancies. METHODS: This ongoing, phase 2, multicentre, open-label, single-arm study was done in 20 centres in the USA...
January 2023: Lancet Haematology
#9
Constantine Tarabanis, Ruina Zhang, Kelsey Grossman, Christina Kaul, Jeffrey D Lorin
Background: Cotton fever is a self-limited, febrile syndrome occurring after the injection of trace amounts of drugs, in particular heroin, extracted from reused cotton filters. It is characterized by non-specific findings, such as fever, tachycardia, and leucocytosis. The leading pathophysiologic explanation suggests it is the result of direct inoculation of the bloodstream with endotoxins from Gram-negative bacilli of the genus Enterobacter , known to colonize all parts of the cotton plant...
July 2022: European Heart Journal. Case Reports
#10
Harshit Gupta, Ashwin Parchani, Arnab Choudhury, Jithesh G, Monika Pathania, Mukesh Bairwa
Scrub typhus, also known as bush typhus, is an acute febrile zoonosis caused by Orientia tsutsugamushi , transmitted by the bite of chigger mite. Patients with scrub typhus can have many different presentations such as acute hearing loss, interstitial pneumonitis, acute respiratory distress syndrome, myocarditis, pericarditis, meningoencephalitis, acute renal failure, acute hepatic failure, and septic shock. The occurrence of multi-organ dysfunction is responsible for high mortality seen in scrub typhus patients...
May 2022: Curēus
#11
JOURNAL ARTICLE
Nchafatso G Obonyo, Peter Olupot-Olupot, Ayub Mpoya, Julius Nteziyaremye, Martin Chebet, Sophie Uyoga, Rita Muhindo, Jonathon P Fanning, Kenji Shiino, Jonathan Chan, John F Fraser, Kathryn Maitland
OBJECTIVES: Fluid bolus resuscitation in African children is harmful. Little research has evaluated physiologic effects of maintenance-only fluid strategy. DESIGN: We describe the efficacy of fluid-conservative resuscitation of septic shock using case-fatality, hemodynamic, and myocardial function endpoints. SETTING: Pediatric wards of Mbale Regional Referral Hospital, Uganda, and Kilifi County Hospital, Kenya, conducted between October 2013 and July 2015...
July 1, 2022: Pediatric Critical Care Medicine
#12
Ndausung Udongwo, Nusha Fareen, Temidayo Abe, Mihir Odak, SmArif Saleh, Laith Zamel
Radiofrequency catheter ablation (RFA) is an effective treatment for recurrent symptomatic atrial fibrillation (AF) despite medical therapy. Complications include cardiac tamponade, pulmonary vein stenosis, and rarely atrial-esophageal fistula (AEF). We present a case of a 77-year-old male patient with a history of persistent AF status post posterior left atrial isolation 50 days prior, who presented to the emergency department with bilateral lower extremity weakness ongoing for an hour. In addition, he reported a non-productive cough, chest discomfort, and dysphagia...
February 2022: Journal of Medical Cases
#13
Lih Khuang Go, Huiling Liew, Hao Li
Objective: Thyrotoxicosis from local invasion of the thyroid gland by an extrathyroidal malignancy is rare. We describe a patient with thyrotoxicosis secondary to invasion of the thyroid gland by an oropharyngeal squamous cell carcinoma (OPSCC). To our best knowledge, this has not been reported. Case Report: A 62-year-old Indian man with histologically proven, p16-negative, cT3N3bM0 (stage IVb) posterior OPSCC was admitted for elective gastrostomy. Biochemical thyroid profile was normal before admission, and there was no thyroid invasion radiologically...
January 2022: AACE Clinical Case Reports
#14
JOURNAL ARTICLE
Mani Ram Krishna, Usha Nandhini Sennaiyan
The multi-inflammatory syndrome in children is a poorly understood febrile illness potentially linked to an immune response to COVID-19 infection. The disease is characterized by fever and elevated acute-phase reactants. A number of children with clinical and laboratory evidence of cardiovascular involvement have normal echocardiograms by conventional assessment. The peak left atrial longitudinal strain obtained by atrial deformation analysis could potentially be diagnostic of this condition in children who do not have abnormalities identified on conventional assessment...
July 2021: Annals of Pediatric Cardiology
#15
JOURNAL ARTICLE
Wei Shan, Guipeng An, Qian Ren, Qun Wang
The SCN1B gene, encoding the voltage-gated Na+ channel beta subunit Nav1.1, was founded as the most clinically relevant epilepsy and Brugadasyndrome gene. Variants in SCN1B resulted in genetic epilepsy with febrile seizures plus, severe Dravet Syndrome (DS), Brugadasyndrome, Atrial Arrhythmias, and Long QT-Syndrome. Here, we generated induced pluripotent stem cells (iPSC) from a normal individual by electroporation of peripheral blood mononuclear cells (PBMC), and further generated a SCN1B-knockout human iPSC line via CRISPR/Cas9 gene editing...
October 2021: Stem Cell Research
#16
JOURNAL ARTICLE
Xing-Jiang Xiong
Huanglian Ejiao Decoction,firstly recorded in Treatise on Febrile Diseases,could be used to treat heat-conversion syndrome of Shaoyin. It has been identified that,the indications of Huanglian Ejiao Decoction include:(1)in modern medicine,it can be used to treat insomnia,arrhythmia,oral ulcer,Xiali,blood syndrome and other diseases;(2)in terms of symptoms and signs,it is mainly used for restlessness,ritability,insomnia,extremely difficult to fall asleep,palpitation,atrial premature beat,ventricular premature beat and other arrhythmias,stomach distension and stuffiness,stomach pain,vomiting,abdominal pain,cramps,lower edge,constipation,blush,red lips,easy bleeding,red tongue,thin or no coating,dry tongue surface,or light red tongue,or dark red,thin white tongue coating,and rapid pulse...
July 2021: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#17
Ali Haider Jafry, Sardar Hassan Ijaz, Murtaza Mazhar, Areeba Shahnawaz, Ali Yousif
INTRODUCTION: Coupled with the increasing use of indwelling vascular catheters and prosthetic cardiac valves is an uptrend in sepsis secondary to fungemia. An insidious onset often shrouds the initial diagnosis, contributing to poor outcomes. Candida infective endocarditis (CIE) is a feared complication of candidemia, associated with high mortality rates. It requires prolonged hospital stays for medical and, often, surgical management. We report a case of a massive intracardiac Candida mass in an adult with native valve CIE...
2021: Case Reports in Infectious Diseases
#18
JOURNAL ARTICLE
Armani M Hawes, Christopher Chou, Ivan Co
An 80-year old man presented to the ED after being found down in his home. He had gone to the restroom to perform straight catheterization, as he normally does for his enlarged prostate, and was found slumped over and confused. On arrival to the ED, he was found to be in atrial fibrillation with rapid ventricular response, febrile, and hypotensive. CT imaging of his head, chest, and abdomen-pelvis was obtained. He was started on broad-spectrum antibiotics and norepinephrine infusion for presumed urinary septic shock and admitted to the medical critical care unit for further management...
June 2021: Chest
#19
MULTICENTER STUDY
Jeff P Sharman, Danielle M Brander, Anthony R Mato, Nilanjan Ghosh, Stephen J Schuster, Suman Kambhampati, John M Burke, Frederick Lansigan, Marshall T Schreeder, Scott D Lunin, Alexander Zweibach, Mikhail Shtivelband, Patrick M Travis, Jason C Chandler, Kathryn S Kolibaba, Peter Sportelli, Hari P Miskin, Michael S Weiss, Ian W Flinn
BACKGROUND: Patients with chronic lymphocytic leukaemia and high-risk features have poorer outcomes on ibrutinib than those without high-risk features. The aim of this study was to assess the benefit of adding ublituximab, an anti-CD20 monoclonal antibody, to ibrutinib therapy in this population. METHODS: We did a randomised, phase 3, multicentre study (GENUINE) of patients aged 18 years or older with relapsed or refractory chronic lymphocytic leukaemia with at least one of 17p deletion, 11q deletion, or TP53 mutation, at 119 clinics in the USA and Israel...
April 2021: Lancet Haematology
#20
Abdi El Mostapha, Al Afifi Mahmoud, Nedjim Abdelkerim Saleh, Dakir Mohamed, Debbagh Adil, Aboutaieb Rachid
Tuberculous epididymitis is caused by Mycobacterium tuberculosis . A 30-year-old patient, with a comorbidity of atrial fibrillation, presented with pain in the left testicular for 1 year. On physical examination revealed a patient febrile at 39 °C with a pain, Scrotal swelling. Laboratory tests, a hyperleukocytosis at 25000/mm3, CRP at 160 mg/l. Scrotal ultrasound showed a Collection of fluid. Surgical exploration found an abscessed cyst at the expense of the epididymis. Due to the risk of epididymis neoplasia, surgery therapy ended up in the course of pharmacotherapy and not after 6 weeks as recommended by the studies...
May 2021: Urology Case Reports
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