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https://www.readbyqxmd.com/read/27862097/phase-ib-trial-of-cabazitaxel-and-tasquinimod-in-men-with-heavily-pretreated-metastatic-castration-resistant-prostate-cancer-mcrpc-the-catch-trial
#1
Andrew J Armstrong, Michael S Humeniuk, Patrick Healy, Russell Szmulewitz, Carolyn Winters, Julie Kephart, Michael R Harrison, Elia Martinez, Kelly Mundy, Susan Halabi, Daniel George
BACKGROUND: Tasquinimod is an immunomodulating and anti-antiangiogenic oral agent with anti-prostate cancer activity in preclinical studies and in clinical trials of men with metastatic castration resistant prostate cancer (mCRPC), including single agent activity and in combination with taxanes. We sought to identify the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of tasquinimod in combination with cabazitaxel and prednisone in men with chemorefractory mCRPC. METHODS: Men with mCRPC who had failed prior docetaxel chemotherapy received cabazitaxel 25 mg/m(2) every 3 weeks with oral tasquinimod at 1 of 3 escalating dose levels (0...
November 16, 2016: Prostate
https://www.readbyqxmd.com/read/27089280/evaluation-of-new-diagnostic-biomarkers-in-pediatric-sepsis-matrix-metalloproteinase-9-tissue-inhibitor-of-metalloproteinase-1-mid-regional-pro-atrial-natriuretic-peptide-and-adipocyte-fatty-acid-binding-protein
#2
COMPARATIVE STUDY
Mashael F Alqahtani, Craig M Smith, Scott L Weiss, Susan Dawson, Hantamalala Ralay Ranaivo, Mark S Wainwright
Elevated plasma concentrations of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), mid-regional pro-atrial natriuretic peptide (mrProANP), and adipocyte fatty-acid-binding proteins (A-FaBPs) have been investigated as biomarkers for sepsis or detection of acute neurological injuries in adults, but not children. We carried out a single-center, prospective observational study to determine if these measures could serve as biomarkers to identify children with sepsis. A secondary aim was to determine if these biomarkers could identify children with neurologic complications of sepsis...
2016: PloS One
https://www.readbyqxmd.com/read/26735141/an-open-label-phase-2-study-of-glycogen-synthase-kinase-3-inhibitor-ly2090314-in-patients-with-acute-leukemia
#3
David A Rizzieri, Sarah Cooley, Olatoyosi Odenike, Lisette Moonan, Kay Hoong Chow, Kimberley Jackson, Xuejing Wang, Leslie Brail, Gautam Borthakur
This open-label, Phase-2 study investigated the safety of LY2090314 (GSK-3 inhibitor) in AML patients. Twenty patients received 40-mg LY2090314 (50-mg ranitidine pretreatment) as follows: Cohort 1 - days 1, 8, and 15 of a 28-d cycle (n = 7); Cohort 2 - days 1, 5, and 9 of a 21-d cycle (n = 6); Cohort 3 - days 1, 5, 9, and 12 of a 21-d cycle (n = 7). Decreased appetite (n = 7) and nausea (n = 4) were the most frequently reported possibly drug-related non-hematologic treatment-emergent adverse events (TEAEs)...
August 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/26596974/efficacy-and-safety-of-micafungin-versus-intravenous-itraconazole-as-empirical-antifungal-therapy-for-febrile-neutropenic-patients-with-hematological-malignancies-a-randomized-controlled-prospective-multicenter-study
#4
RANDOMIZED CONTROLLED TRIAL
Seong Hyun Jeong, Dae Young Kim, Jun Ho Jang, Yeung-Chul Mun, Chul Won Choi, Sung-Hyun Kim, Jin Seok Kim, Joon Seong Park
Micafungin, a clinically important echinocandin antifungal drug, needs to be investigated as empirical therapy in febrile neutropenia in comparison with azole compounds. A prospective randomized study was conducted to compare clinical outcomes between micafungin and intravenous itraconazole as an empirical therapy for febrile neutropenia in hematological malignancies. The antifungal drug (micafungin 100 mg or itraconazole 200 mg IV once daily) was given for high fever that was sustained despite the administration of appropriate antibiotics...
January 2016: Annals of Hematology
https://www.readbyqxmd.com/read/26317683/phase-i-study-evaluating-the-safety-and-efficacy-of-oral-panobinostat-in-combination-with-radiotherapy-or-chemoradiotherapy-in-patients-with-inoperable-stage-iii-non-small-cell-lung-cancer
#5
Harminder S Takhar, Nimit Singhal, Raghu Gowda, Michael Penniment, Parineet Takhar, Michael P Brown
Panobinostat is a radiosensitizing agent and targets the epigenetics of malignancy. This phase I study evaluated the safety and efficacy of combining oral panobinostat with radiotherapy (RT) or chemoradiotherapy (CRT) in patients with inoperable stage III non-small-cell lung cancer. This study had a parallel dose-escalating design combining oral panobinostat twice a week (dose escalations 20, 30, 45 mg) with either palliative RT (group A) or radical CRT (group B) using a standard chemotherapy protocol of cisplatin and etoposide...
November 2015: Anti-cancer Drugs
https://www.readbyqxmd.com/read/26317413/prevalence-of-congenital-heart-disease-in-xinjiang-multi-ethnic-region-of-china
#6
Fen Liu, Yi-Ning Yang, Xiang Xie, Xiao-Mei Li, Xiang Ma, Zhen-Yan Fu, Bang-Dang Chen, Ying Huang, Chun-Fang Shan, Yi-Tong Ma, Xiao-Ming Gao
BACKGROUND: The prevalence and risk factors of congenital heart disease among Xinjiang, northwestern part of China is currently unknown. METHODS: This multiple-ethnic, community-based, cross-sectional study was conducted to estimate the prevalence and distribution of congenital heart disease (CHD) in Xinjiang, northwestern part of China. Four major ethnics, Uygur, Han, Kazak, and Hui children in this region were investigated during February 2010 and May 2012. RESULTS: A total of 14,530 children (0-18 yr) were examined...
2015: PloS One
https://www.readbyqxmd.com/read/26181497/an-interesting-case-of-viral-pericarditis
#7
Kelly Marie van Diepen, Claudia Lace de Almeida, April Jacqueline Kam
A previously healthy 14-year-old girl presented to the emergency department with a 3-day history of upper respiratory symptoms and 2 syncopal episodes. She was initially febrile, tachycardic, and tachypneic; the initial electrocardiogram showed diffuse T-wave inversions and right atrial enlargement. There was no pericardial effusion on bedside and formal echocardiography; the latter, however, revealed a hyperechogenic pericardium. A viral swab was positive for influenza B. Treatment with intravenous rehydration and ibuprofen was started with good response...
May 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/26096756/-agranulocytosis-related-to-fluindione-a-case-report
#8
S Ngo, Y Benhamou, G Armengol, G Sauvêtre, N Cailleux-Talbot, N Massy, G Buchonnet, H Lévesque
INTRODUCTION: While in most countries warfarin is the preferred anti-vitamin K, fluindione, a molecule with a prolonged half-life remains largely prescribed in France. Some of its side effects, including immuno-allergic complications, remain poorly understood. CASE REPORT: A 77-year-old woman presented with a febrile severe neutropenia of immunoallergic mechanism with a favourable outcome associated with fluindione, introduced 25 days earlier for the treatment of atrial fibrillation...
January 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/25285800/efficacy-toxicity-and-mortality-of-autologous-sct-in-multiple-myeloma-patients-with-dialysis-dependent-renal-failure
#9
R St Bernard, L Chodirker, E Masih-Khan, H Jiang, N Franke, V Kukreti, R Tiedemann, S Trudel, D Reece, C I Chen
Numerous studies have reported the feasibility and safety of autologous SCT (ASCT) in patients with multiple myeloma (MM) and mild to moderate renal impairment, but there are limited data in dialysis-dependent patients. In this retrospective study, we reviewed the toxicities and efficacy outcomes of 33  MM patients with dialysis-dependent renal failure who underwent ASCT at our institution from 1998 to 2012. The most common grade 3 non-hematologic toxicities were mucositis (49%), infection (15%) and bleeding (6%)...
January 2015: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/24974673/tachycardia-in-a-newborn-with-enterovirus-infection
#10
Lidija Banjac, Drasko Nikcević, Danijela Vujosević, Janja Raonić, Goran Banjac
Enterovirus infections are common in the neonatal period. Newborns are at a higher risk of severe disease including meningoencephalitis, sepsis syndrome, cardiovascular collapse, or hepatitis. The mechanism of heart failure in patients with enterovirus infection remains unknown. Early diagnosis may help clinicians predict complications in those infants initially presenting with severe disease. An 11-day-old male newborn was admitted to our neonatal intensive care unit because of tachycardia and crises of cyanosis...
March 2014: Acta Clinica Croatica
https://www.readbyqxmd.com/read/24974563/severe-babesiosis-presenting-as-acute-respiratory-distress-syndrome-in-an-immunocompetent-patient
#11
Veena Panduranga, Anupam Kumar
Babesiosis is a tick-borne illness caused by the intraerythrocytic parasite Babesia microti. Adult respiratory distress syndrome (ARDS) is a complication of B. microti infection and generally presents later in the course of the disease. We present a case of babesiosis presenting with ARDS. A 59-year-old male with history of hypertension and atrial fibrillation presented with one day of progressive shortness of breath. The patient returned from a trip to Massachusetts one day prior. On arrival to the emergency department (ED) the patient was noted to be febrile with tachycardia, tachypnea, and hypoxia and was intubated for respiratory failure...
May 2014: Connecticut Medicine
https://www.readbyqxmd.com/read/24931854/sudden-cardiac-death-from-parvovirus-b19-myocarditis-in-a-young-man-with-brugada-syndrome
#12
Zoltan Juhasz, Laszlo Tiszlavicz, Beatrix Kele, Gabriella Terhes, Judit Deak, Laszlo Rudas, Eva Kereszty
Cardiovascular diseases are the leading cause of sudden death all over the world. The aetiology of sudden cardiac death among young adults includes Brugada syndrome and myocarditis. Brugada syndrome is a genetic abnormality of sodium channels in the myocardium with a characteristic electrocardiographic pattern. Myocarditis has several aetiologies including infections. One of the most common cardiotropic viruses is parvovirus B19. This infection presents as a febrile illness in childhood and may result in fatal outcome, more frequently in adults...
July 2014: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/24919764/a-serendipitous-identification-of-a-lead-extraction-complication
#13
George Madden, Omar Farrukh, Stavros Stavrakis, C A Sivaram
A 57-year-old male with a dual chamber pacemaker and symptomatic, persistent atrial fibrillation (AF) accompanying a febrile illness presented for elective transesophageal echocardiography (TEE)-guided cardioversion. The patient was found to have a large 2.5 cm × 2.3 cm, mobile mass attached to the right atrial lead. Following device and lead extraction, he developed progressive shortness of breath which was attributed to his underlying arrhythmia. One month later, AF ablation was pursued and preablation TEE revealed a dilated main pulmonary artery with a 1...
September 2014: Echocardiography
https://www.readbyqxmd.com/read/24841571/an-adverse-reaction-to-a-medication-given-to-treat-an-adverse-reaction-a-teachable-moment
#14
Nicholas J Rohrhoff, Diana B McNeill, Joel C Boggan
No abstract text is available yet for this article.
July 2014: JAMA Internal Medicine
https://www.readbyqxmd.com/read/24770978/-fever-atrial-fibrillation-and-angina-pectoris-in-a-58-year-old-man
#15
M Groebner, T Südhoff, M Doering, M Kirmayer, T Nitsch, L Prügl, W Römer, H Wolf, J Tacke, P Massoudy, T Nüsse, D Elsner
Primary cardiac lymphoma (PCL) respresents a very rare type of cardiac tumour. This report illustrates a case of PCL in an immunocompetent 58-year-old man presenting with atrial fibrillation and febrile syndrome. Comprehensive imaging [computer tomography (CT), cardiac magnetic resonance imaging (cMRI), 3-dimensional transesophageal echocardiography (3D-TEE)] identified a large right atrial tumour, leading to pericardial effusion. Isolated cardiac involvement was confirmed by positron emission tomography (PET)-CT...
May 2014: Der Internist
https://www.readbyqxmd.com/read/24711538/clinical-reasoning-a-68-year-old-man-with-a-first-presentation-of-status-epilepticus
#16
Logan Schneider, John C Probasco, Scott D Newsome
A 64-year-old man with transfusion-dependent myelodysplastic syndrome (MDS), hypertension, chronic obstructive pulmonary disease, hypothyroidism, blindness from treated syphilitic chorioretinitis, and no prior seizure history presented in generalized status epilepticus. His daily home medication regimen included prednisone 20 mg (chronic therapy for MDS), diltiazem 120 mg, digoxin 250 μg, tiotropium 80 μg, and levothyroxine 112 μg. On admission he was febrile to 39.9 °C and in atrial fibrillation with rapid ventricular rate...
April 8, 2014: Neurology
https://www.readbyqxmd.com/read/24174958/mercury-promotes-catecholamines-which-potentiate-mercurial-autoimmunity-and-vasodilation-implications-for-inositol-1-4-5-triphosphate-3-kinase-c-susceptibility-in-kawasaki-syndrome
#17
REVIEW
Deniz Yeter, Richard Deth, Ho-Chang Kuo
Previously, we reviewed biological evidence that mercury could induce autoimmunity and coronary arterial wall relaxation as observed in Kawasaki syndrome (KS) through its effects on calcium signaling, and that inositol 1,4,5-triphosphate 3-kinase C (ITPKC) susceptibility in KS would predispose patients to mercury by increasing Ca(2+) release. Hg(2+) sensitizes inositol 1,4,5-triphosphate (IP3) receptors at low doses, which release Ca(2+) from intracellular stores in the sarcoplasmic reticulum, resulting in delayed, repetitive calcium influx...
September 2013: Korean Circulation Journal
https://www.readbyqxmd.com/read/23693103/-perinatal-infection-by-rubella-virus-in-breast-fed-babies-with-congenital-heart-disease
#18
Fortino Solórzano-Santos, Selene Jeannette Bárcenas-López, Gloria C Huerta-García, María Guadalupe Miranda-Novales, María Teresa Alvarez-Y Muñoz, José Guillermo Vázquez-Rosales
BACKGROUND: seroepidemiological surveys suggest that approximately 20 % of women of childbearing age are susceptible to rubella. It is necessary to detect congenital rubella cases. Our objective was to determine the frequency of perinatal infection by rubella virus (RV) in infants with congenital heart disease. METHODS: prospective, cross-sectional study. We studied hospitalized and outpatients from September 2007 to December 2008. Neonates and infants under one year of age with congenital heart disease were included...
March 2013: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/23453583/two-dosing-regimens-of-tosedostat-in-elderly-patients-with-relapsed-or-refractory-acute-myeloid-leukaemia-opal-a-randomised-open-label-phase-2-study
#19
RANDOMIZED CONTROLLED TRIAL
Jorge Cortes, Eric Feldman, Karen Yee, David Rizzieri, Anjali S Advani, Anthony Charman, Richard Spruyt, Martin Toal, Hagop Kantarjian
BACKGROUND: Tosedostat is a novel oral aminopeptidase inhibitor with clinical activity in a previous phase 1-2 study in elderly patients with relapsed or refractory acute myeloid leukaemia (AML). We aimed to compare two dosing regimens of tosedostat. METHODS: In this randomised phase 2 study, patients aged 60 years or older with AML that had relapsed after a first complete remission lasting less than 12 months, or had achieved no previous complete remission, were randomly assigned (1:1) to receive as first salvage tosedostat 120 mg once daily for 6 months or 240 mg once daily for 2 months followed by 120 mg for 4 months...
April 2013: Lancet Oncology
https://www.readbyqxmd.com/read/23406789/results-of-laparoscopic-surgery-for-abdominal-aortic-aneurysms-in-patients-with-standard-surgical-risk-and-anatomic-criteria-compatible-with-evar
#20
COMPARATIVE STUDY
Isabelle Javerliat, Clément Capdevila, Alain Beauchet, Isabelle Di Centa, Olivier Goëau-Brissonnière, Marc Coggia
BACKGROUND: The recent Anévrisme de l'aorte abdominale: Chirurgie versus Endoprothèse (ACE) study showed that open surgery of infrarenal abdominal aortic aneurysms (AAAs) provided very good results in patients with standard surgical risk, with good anatomic results for endovascular aneurysm repair (EVAR). The goal of the current study was to show that aortic laparoscopy is a minimally invasive alternative to open surgery while avoiding the complications associated with laparotomy. METHODS: From February 2002 to August 2010, the authors performed 239 laparoscopic AAA repairs...
May 2013: Annals of Vascular Surgery
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