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Spastic cerebral palsy

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https://www.readbyqxmd.com/read/29318610/demographic-and-modifiable-factors-associated-with-knee-contracture-in-children-with-cerebral-palsy
#1
Erika Cloodt, Andreas Rosenblad, Elisabet Rodby-Bousquet
AIM: To identify the prevalence of knee contracture and its association with gross motor function, age, sex, spasticity, and muscle length in children with cerebral palsy (CP). METHOD: Cross-sectional data for passive knee extension were analysed in 3 045 children with CP (1 756 males, 1 289 females; mean age 8y 1mo [SD 3.84]). CP was classified using the Gross Motor Function Classification System (GMFCS) levels I (n=1 330), II (n=508), III (n=280), IV (n=449), and V (n=478)...
January 10, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29305858/identification-of-a-candidate-enhancer-for-dmrt3-involved-in-spastic-cerebral-palsy-pathogenesis
#2
Naoto Kubota, Toshifumi Yokoyama, Nobuhiko Hoshi, Mikita Suyama
Cerebral palsy (CP) is a major neuronal disease and the most common movement disorder in children. Although environmental factors leading to CP have been greatly investigated, the genetic mechanism underlying CP is not well understood. Here we focused on two clinical reports that characterized a deletion involving the KANK1 gene locus in the 9p24.3 region. One report shows spastic CP and the other shows no spastic CP phenotype. Based on the epigenetic status and evolutionary conservation, we first found a functional genomic element at the noncoding region that was deleted only in patients with spastic CP...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29304114/comparison-of-calf-muscle-architecture-between-asian-children-with-spastic-cerebral-palsy-and-typically-developing-peers
#3
Ying Chen, Lu He, Kaishou Xu, Jinling Li, Buyun Guan, Hongmei Tang
OBJECTIVE: To compare the muscle thickness, fascicle length, and pennation angle of the gastrocnemius, soleus, and tibialis anterior between Asian children with spastic cerebral palsy (CP) and typically developing (TD) peers. METHODS: This cross-sectional study involved a total of 72 children with hemiplegic CP (n = 24), and diplegic CP (n = 24) and their TD peers (n = 24). Muscle architecture was measured at rest using ultrasound. Clinical measures included gross motor function and a modified Ashworth scale...
2018: PloS One
https://www.readbyqxmd.com/read/29303031/the-relationship-between-hand-function-and-overlapping-motor-representations-of-the-hands-in-the-contralesional-hemisphere-in-unilateral-spastic-cerebral-palsy
#4
Michelle Marneweck, Hsing-Ching Kuo, Ana R P Smorenburg, Claudio L Ferre, Veronique H Flamand, Disha Gupta, Jason B Carmel, Yannick Bleyenheuft, Andrew M Gordon, Kathleen M Friel
BACKGROUND: In many children with unilateral spastic cerebral palsy (USCP), the corticospinal tract to the affected hand atypically originates in the hemisphere ipsilateral to the affected hand. Such ipsilateral connectivity is on average a predictor of poor hand function. However, there is high variability in hand function in these children, which might be explained by the complexity of motor representations of both hands in the contralesional hemisphere. OBJECTIVE: To measure the link between hand function and the size and excitability of motor representations of both hands, and their overlap, in the contralesional hemisphere of children with USCP...
January 1, 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29301539/development-of-an-inventory-of-goals-using-the-international-classification-of-functioning-disability-and-health-in-a-population-of-non-ambulatory-children-and-adolescents-with-cerebral-palsy-treated-with-botulinum-toxin-a
#5
Linda Nguyen, Ronit Mesterman, Jan Willem Gorter
BACKGROUND: In the management of hypertonicity in children with cerebral palsy (CP), goals should be clearly identified in order to evaluate the effectiveness of botulinum toxin A (BoNT-A) treatment, specifically in non-ambulatory children and adolescents, Gross Motor Function Classification System (GMFCS), level IV or V. A retrospective chart review (Mesterman et al., 2013) identified the need for the development of a set of specific and meaningful goals linked to the International Classification of Functioning, Disability and Health (ICF) for future goal setting and evaluation in this population...
January 4, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29282739/clinical-acceptability-of-the-sense_assess%C3%A2-kids-children-and-youth-perspectives
#6
Susan Taylor, Belinda McLean, Eve Blair, Leeanne Mary Carey, Jane Valentine, Sonya Girdler, Catherine Elliott
BACKGROUND: The sense_assess© kids is a standardised, norm-referenced assessment designed to measure the functional somatosensation capacity of the upper limb of children with cerebral palsy. The objective of the current study was to determine if the sense_assess© kids was clinically acceptable to children and youth. METHODS: A questionnaire was completed by participants following administration of the sense_assess© kids by a trained occupational therapist. Twenty-six children with spastic hemiplegic cerebral palsy (aged 6-15 years six months; mean 10 years eight months; 16 boys) were recruited...
December 28, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/29280208/medial-gastrocnemius-muscle-stiffness-cannot-explain-the-increased-ankle-joint-range-of-motion-following-passive-stretching-in-children-with-cerebral-palsy
#7
Barbara M Kalkman, Lynn Bar-On, Francesco Cenni, Constantinos N Maganaris, Alfie Bass, Gill Holmes, Kaat Desloovere, Gabor J Barton, Thomas D O'Brien
Stretching is often used to increase/maintain joint range of motion (ROM) in children with cerebral palsy (CP) but the effectiveness of these interventions is limited. Therefore, this study aimed to determine the acute changes in muscle-tendon lengthening properties that contribute to increased ROM after a bout of stretching in children with CP. Eleven children with spastic CP (age:12.1(3)y, 5/6 hemiplegia/diplegia, 7/4 GMFCS level I/II) participated in this study. Each child received 3 sets of 5 × 20 s passive, manual static dorsiflexion stretches separated by 30 s rest, and 60 s rest between sets...
December 26, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29273816/novel-mealtime-duration-measures-reliability-and-preliminary-associations-with-clinical-feeding-and-swallowing-performance-in-self-feeding-children-with-cerebral-palsy
#8
Avinash Mishra, Justine J Sheppard, Cagla Kantarcigil, Andrew M Gordon, Georgia A Malandraki
Purpose: The purpose of this study is to examine (a) the reliability of newly developed measures of mealtime duration and (b) their relationship to clinical feeding/swallowing performance in children with spastic cerebral palsy (SCP). Method: Seventeen self-feeding children (9 boys, 8 girls) with SCP (age range = 5;1 [years;months] to 17;6, Gross Motor Function Classification System range = I-IV) were assessed during mealtimes using the Dysphagia Disorder Survey (DDS; Sheppard, Hochman, & Baer, 2014)...
December 22, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29249551/validation-of-a-clinical-prediction-model-for-the-development-of-neuromuscular-scoliosis-a-multinational-study
#9
Carlo M Bertoncelli, Domenico Bertoncelli, Leonard Elbaum, Michal Latalski, Paola Altamura, Charles Musoff, Virginie Rampal, Federico Solla
BACKGROUND: The objective of this study was to evaluate the performance of a clinical prediction model of neuromuscular scoliosis via external validation. METHODS: We analyzed a series of 120 patients (mean age ± standard deviation, 15.7 ± 1.8 years; range: 12 to 18 years) with cerebral palsy, severe motor disorders, and cognitive impairment with and without neuromuscular scoliosis treated in two specialized units (70 patients from Nice, France, and 50 patients from Lublin, Poland) in a cross-sectional, double-blind study...
November 20, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29231322/-acupuncture-based-on-nourishing-spleen-and-kidney-and-dredging-the-governor-vessel-for-motor-function-and-adl-in-children-with-spastic-cerebral-palsy
#10
Yong Zhao, Zhenhuan Liu, Bingxu Jin
OBJECTIVE: To compare the effects of acupuncture based on nourishing spleen and kidney and dre-dging the governor vessel (GV) combined with rehabilitation and simple rehabilitation for children with spastic cere-bral palsy. METHODS: One hundred and twenty patients were randomly assigned into an observation group and a control group, 60 cases in each one. Physicotherapeutics and hand function training were used in the control group for 3 sessions with 20 d at the interval, 20 times as one session, once a day...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29228927/treatment-with-botulinum-toxin-a-in-a-total-population-of-children-with-cerebral-palsy-a-retrospective-cohort-registry-study
#11
Maria Franzén, Gunnar Hägglund, Ann Alriksson-Schmidt
BACKGROUND: Botulinum toxin A (BTX-A) has been used to reduce spasticity in children with cerebral palsy (CP) for decades. The purpose of this study was to analyze to what extent BTX-A treatment was used to treat spasticity in a total population of children with CP. We investigated 1) the use of BTX-A in relation to age, sex, and Gross Motor Function Classification System (GMFCS) level, 2) the most common muscle groups treated with BTX-A in relation to the same variables, and 3) changes in the proportions of children treated with BTX-A between two time points (2010 and 2015)...
December 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29207820/relationship-between-trunk-control-and-balance-in-children-with-spastic-cerebral-palsy-a-cross-sectional-study
#12
Sivatejaa Panibatla, Vijaya Kumar, Amitesh Narayan
Introduction: Trunk control is impaired in children with Cerebral Palsy (CP) thus influencing their functional balance. However, there is a paucity of literature determining the relationship between trunk control and balance in children with CP. Aim: To find the relationship between trunk control and balance by means of Trunk Control Measurement Scale (TCMS) and Paediatric Balance Scale (PBS). Materials and Methods: Twenty four children {age range 8-14 years, Gross Motor Function Classification System (GMFCS) Level I-III} with spastic CP were recruited and evaluated using TCMS and PBS...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29200489/flexion-deformities-of-the-wrist-and-fingers-in-spastic-cerebral-palsy-a-protocol-of-management
#13
Tarek Hassan Abdelaziz, Shady Samir Elbeshry, Mahmoud Mahran, Ahmad Saeed Aly
Background: Literature is confusing regarding grading and treatment of flexion deformities of wrist and fingers in spastic cerebral palsy (CP). The most established classification is that described by Zancolli; unfortunately, it has its shortcomings which we experienced in the beginning of our approach to manage this rather difficult deformity. We thus modified Zancolli's classification and developed a classification system and treatment protocol. Materials and Methods: Thirty patients with spastic CP were operated upon due to flexion deformity of the wrist and fingers and were included in this study...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29197788/effects-of-antagonistic-and-synergistic-muscles-co-activation-on-mechanics-of-activated-spastic-semitendinosus-in-children-with-cerebral-palsy
#14
Filiz Ateş, Yener Temelli, Can A Yucesoy
OBJECTIVES: Most activities involve co-activation of several muscles and epimuscular myofascial force transmission (EMFT) can affect their mechanics. This can be relevant for spastic muscles of cerebral palsy (CP) patients. Isometric spastic semitendinosus (ST) forces vs. knee angle (KA-FST) data were collected intra-operatively to test the following hypotheses: (i) Inter-antagonistic EMFT elevates FST, (ii) changes the shape of KA-FST characteristics, (iii) reduces the muscle's joint range of force exertion (Range-FST) and (iv) combined inter-antagonistic and synergistic EMFT further changes those effects...
November 30, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29193663/clinical-and-genetic-characterization-of-ap4b1-associated-spg47
#15
Darius Ebrahimi-Fakhari, Chi Cheng, Kira Dies, Amelia Diplock, Danielle B Pier, Conor S Ryan, Brendan C Lanpher, Jennifer Hirst, Wendy K Chung, Mustafa Sahin, Elisabeth Rosser, Basil Darras, James T Bennett
The hereditary spastic paraplegias (HSPs) are a heterogeneous group of disorders characterized by degeneration of the corticospinal and spinocerebellar tracts leading to progressive spasticity. One subtype, spastic paraplegia type 47 (SPG47 or HSP-AP4B1), is due to bi-allelic loss-of-function mutations in the AP4B1 gene. AP4B1 is a subunit of the adapter protein complex 4 (AP-4), a heterotetrameric protein complex that regulates the transport of membrane proteins. Since 2011, 11 individuals from six families with AP4B1 mutations have been reported, nine of whom had homozygous mutations and were from consanguineous families...
November 28, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29185676/effect-of-physiotherapeutic-intervention-on-the-gait-after-the-application-of-botulinum-toxin-in-children-with-cerebral-palsy-systematic-review
#16
Paulo R Fonseca, Renata C Franco de Moura, Manuela Galli, Claudia Santos Oliveira
BACKGROUND: Cerebral palsy is a group of movement and posture development disorders. 90% of this population has gait impairment, often due to the presence of spasticity. A number of studies emphasize the importance of combined physical therapy with botulinum toxin A treatment. However, no consensus can be reached concerning the content of the physiotherapy programme after treatment with botulinum toxin A. AIM: The purpose of the present study was to investigate, through a systematic review of the literature, the effects of physiotherapeutic intervention on gait after botulinum toxin application in children with cerebral palsy...
November 29, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29185624/the-effect-of-adapted-sports-in-quality-of-life-and-biopsychosocial-profile-of-children-and-adolescents-with-cerebral-palsy
#17
Luzanira Correia Feitosa, Sandra Regina Baggio Muzzolon, Danielle Caldas Bufara Rodrigues, Ana Chrystina de Souza Crippa, Marise Bueno Zonta
OBJECTIVE: The participation in sports and recreational activities promotes inclusion and the quality of life (QOL) for people with some type of disability. This study aims to evaluate and describe the effect of adapted sports (AS) on the QOL and biopsychosocial profile of children/adolescents with cerebral palsy (CP). METHODS: Forty-seven children/adolescents with CP were evaluated and referred to AS (soccer and swimming). The QOL was evaluated by the Pediatric Outcome Data Collection Instrument (PODCI) and the biopsychosocial profile by the Behavior Checklist for Children/Adolescents (CBCL)...
October 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/29184312/effects-of-4-weeks-of-dynamic-neuromuscular-stabilization-training-on-balance-and-gait-performance-in-an-adolescent-with-spastic-hemiparetic-cerebral-palsy
#18
Do-Hyun Kim, Duk-Hyun An, Won-Gyu Yoo
[Purpose] The purpose of this study investigated the effects of 4 weeks of dynamic neuromuscular stabilization training on balance ability. [Subject and Methods] An adolescent with spastic hemiparetic cerebral palsy was recruited. The subject performed 4 weeks of dynamic neuromuscular stabilization training. We assessed the balance subtest of the Bruininks-Oseretsky Test of Motor Proficiency-Second Edition, the 10-meter walk test, and the 6-min walk test. [Results] The balance subtest scores were improved significantly after training...
October 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29184291/the-effects-of-task-oriented-training-on-hand-dexterity-and-strength-in-children-with-spastic-hemiplegic-cerebral-palsy-a-preliminary-study
#19
Jong-Hoon Moon, Jin-Hwa Jung, Suk-Chan Hahm, Hwi-Young Cho
[Purpose] The purpose of this study was to investigate the effects of task-oriented training (TOT) on hand dexterity and strength in children with spastic hemiplegic cerebral palsy. [Subjects and Methods] Twelve children with spastic hemiplegic cerebral palsy were randomly assigned to either the TOT group (n=6) or the control group (n=6). In both groups, conventional occupational therapy was performed 40-min/day, 2 times a week, for 4 weeks. In the TOT group, TOT was additionally performed for 20 min, and the control group received usual care...
October 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29184279/relationship-between-gross-motor-function-and-the-function-activity-and-participation-components-of-the-international-classification-of-functioning-in-children-with-spastic-cerebral-palsy
#20
Byoung-Hee Lee
[Purpose] This study aimed to evaluate the relationship between gross motor function, measured using the Gross Motor Function Measure (GMFM), Gross Motor Function Classification System (GMFCS), Manual Ability Classification System (MACS), and Functional Independence Measure for Children (WeeFIM), and Function, and Activity and Participation components of the International Classification of Functioning, Disability, and Health-Child and Youth Check List (ICF-CY) in children with spastic cerebral palsy (CP). [Subjects and Methods] Seventy-seven children with spastic CP participated in the study...
October 2017: Journal of Physical Therapy Science
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