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Cutaneous mucinous lesions

Roumina Hasan, Sandeep Kumar, Anuradha Ck Rao, Rajagopal Kadavigere
A 55-year-old woman presented with a mucopurulent sinusal discharge from the right supragluteal region, with symptoms over the previous five months. This abscess began as a slowly swelling growth, which eventually turned into a discharging sinus, and she was diagnosed with a gluteal abscess. The patient underwent incisional drainage, and intra-operatively, the sinus tract could be seen extending to the retroperitoneum. A subsequent CT scan and an MRI of the abdomen revealed a large heterogeneous retroperitoneal cystic mass on the right side of midline, extending inferiorly into the anterior thigh along the iliopsoas...
July 2016: Malaysian Journal of Medical Sciences: MJMS
Kang-Ling Kuo, Li-Yu Lee, Tseng-Tong Kuo
Cutaneous mucinoses encompass a variety of cutaneous disorders. Cutaneous focal mucinosis (CFM) was originally described as an asymptomatic solitary lesion characterized by abundant focal cutaneous mucin deposits. However, multiple focal mucinous lesions associated with systemic diseases have also been designated as CFM. Our clinicopathological study of 11 cases of solitary lesions confirmed that CFM is a unique primary cutaneous mucinosis unrelated to mucinosis-associated systemic diseases. We suggest calling this group of CFM lesions "solitary CFM" to distinguish them from multiple CFM associated with mucinosis associated systemic diseases...
July 23, 2016: Journal of Dermatology
Natalia Mukai, Lílian Vital Pinheiro, Maria de Lourdes Setsuko Ayrizono, Guilherme Cardinali Barreiro, Paulo Kharmandayan, Mariana Hanayo Akinaga, Adriano Mesquita Bento, Carlos Augusto Real Martinez, Rita Barbosa de Carvalho, Marc Ward, Cláudio Saddy Rodrigues Coy, Raquel Franco Leal
INTRODUCTION: Chronic suppurative hidradenitis (CSH) is a benign condition that can affect the perineal region and often leads to the formation of abscesses and fistulas. It is rare for CSH to undergo malignant degeneration into mucinous adenocarcinoma. PRESENTATION OF CASE: We report a case of a 55-year-old male patient with perineal CSH who suffered worsening long-term pain despite multiple surgical procedures to alleviate his symptoms. Pelvic magnetic resonance imaging (MRI) showed multiloculated cystic lesion on the left side wall of the distal rectum with gluteal extension...
2016: International Journal of Surgery Case Reports
Reza Yaghoobi, Arezou Bagherzade, Maryam Aliabdi, Parvin Kheradmand, Afshin Kazerouni, Amir Feily
A 52-year-old woman was admitted with a 3 weeks history of periorbital edema and lips swelling. She developed several subcutaneous firm erythematous papules and nodules on the face, scalp and two indurated plaques on the upper back and left forearm. These lesions grew rapidly. The patient had a positive history of epileptic seizures since childhood. General examination was normal. There was a mild pitting edema on her hands and feet. Laboratory data were within normal limits. Histopathological examination revealed a well circumscribed accumulation of mucin in the dermis...
January 2016: Acta Medica Indonesiana
Nicole Umanoff, Ari Fisher, J Andrew Carlson
BACKGROUND: Wong-type dermatomyositis (DM) exhibits simultaneous pityriasis rubra pilaris (PRP) features. CASE REPORT: A 50-year-old woman presented with a heliotrope rash, Gottron's papules, and a poikilodermic, erythematous rash in shawl distribution without evidence of muscle weakness. Despite topical corticosteroids, the eruption progressed 9 months later to include generalized hyperkeratotic follicular papules, islands of sparing, and atrophic macules with a collarette of scale suggestive of porokeratosis...
January 2015: Dermatopathology (Basel, Switzerland)
Werner Kempf, Britta von Stumberg, Natalja Denisjuk, Beata Bode, Franco Rongioletti
Cutaneous focal mucinosis (CFM) is a localized form of cutaneous dermal mucinosis clinically presenting as an asymptomatic skin-colored papule or nodule. The etiopathogenesis of CFM is unclear, but it is thought to represent a reactive lesion. Although trauma has been suspected as a triggering factor, it has never been proven in cases of CFM. We report 2 male patients with trauma-induced CFM arising at the mammary areola, which is an unusual site for CFM. Both male patients presented with a solitary nodular lesion of up to 2 cm in diameter at the right areola...
January 2014: Dermatopathology (Basel, Switzerland)
Ahmed Dehal, Sunal Patel, Sean Kim, Emanuel Shapera, Farabi Hussain
Cutaneous metastasis of rectal cancer is rare. It typically indicates widespread disease and poor prognosis. We report an exceedingly rare case of rectal cancer with metastasis to the skin and review the literature on cutaneous metastasis of rectal cancer. A 47-year-old man presented with stage IV unresectable adenocarcinoma of the rectum and received palliative chemoradiation for local pain control. About a year later he developed extensive skin lesions involving the genital area, bilateral groin, and perineum...
2016: Permanente Journal
K Nakamura, M Jinnin, H Kudo, K Inoue, W Nakayama, N Honda, I Kajihara, S Masuguchi, S Fukushima, H Ihn
BACKGROUND: Dermatomyositis (DM) and systemic lupus erythematosus (SLE) have common skin features, including dermal mucin deposition and interferon signature, although their roles are unknown. OBJECTIVES: To identify common or specific molecular changes in DM and SLE skin. METHODS: Proteomic analysis was performed using DM and healthy skin. Glycosaminoglycans were analysed by high-performance liquid chromatography. RESULTS: The expression of 60 proteins was upregulated or downregulated in DM skin compared with healthy skin in the proteomic analysis...
May 2016: British Journal of Dermatology
Catherine M Nguyen, Hadas Skupsky, David Cassarino
Folliculosebaceous cystic hamartoma is a distinctive cutaneous hamartoma composed of follicular, sebaceous, and mesenchymal components. The lesions are most commonly found on the face and scalp of young adults, with approximately 30% occurring in the nasal or paranasal regions of the face. The clinical differential diagnoses are extensive and include epidermoid cyst, dermal nevus, soft fibroma, and adnexal tumors including sebaceous neoplasms. Here, the authors present a case of a 24-year-old man who presented for evaluation of an asymptomatic growth on the nose, which had slowly enlarged over 9 years...
December 2015: American Journal of Dermatopathology
Carine Merklen-Djafri, Didier Bessis, Camille Frances, Nicolas Poulalhon, Sébastien Debarbieux, Nadège Cordel, Dan Lipsker
The nosology of bullous lesions or equivalents (vesicles, erosions, and crusts) in patients with lupus erythematosus (LE) is rarely addressed.The primary aim of this study was to draw up a precise phenotypic inventory of such skin lesions; the secondary objective was to assess a potential relationship between the different types of loss of epidermis and extracutaneous lupus manifestations.We conducted a retrospective multicenter study including 22 patients with definite LE and bullous lesions or equivalents...
November 2015: Medicine (Baltimore)
Allison R Larson, Alvaro C Laga, Scott R Granter
OBJECTIVES: Still disease is a rare disorder characterized by seronegative arthralgias/arthritis, spiking fever, and either an evanescent salmon-colored rash or persistent papules and plaques. METHODS: We describe the clinical and biopsy findings in 10 patients with the evanescent rash of Still disease. RESULTS: Fourteen biopsy specimens were studied from seven women and three men with a mean age of 44.4 years. The skin lesions were typically erythematous macules, papules, or plaques with a median duration of 5 weeks...
December 2015: American Journal of Clinical Pathology
Laura Frances, Isabel Betlloch, Maria Leiva-Salinas, Irene Marin, Jose Carlos Pascual
BACKGROUND: Cutaneous lupus in childhood is usually associated with systemic lupus erythematosus (LE). Linear cutaneous LE (LCLE) is an unusual presentation mostly seen in children and young adults. METHODS: We report a rare case of cutaneous subacute LE with a segmentary pattern following the lines of Blaschko in an 18-month-old girl with a 2-month history of persistent, linear, asymptomatic, erythematous lesions along the right arm. The clinical diagnosis at presentation was lichen striatus...
February 2016: International Journal of Dermatology
Agathe Aoun, Leila Dufrenot-Petitjean-Roget, Emmanuelle Amazan, Christian Derancourt, Marina Alexandre, Danièle Quist, Maggy Grossin, Vincent Molinié
INTRODUCTION: Chondroid syringoma (CS) is a rare cutaneous tumor characterized by mixte epithelial and mesenchymal component. The confident histological diagnosis can be obtained by immuno-histochemistry study. Here we present 10 new cases with their clinico-hystological characteristics. METHODS: The 10 cases were observed between January 2000 and august 2013, in Fort-de-France and Louis-Mourier universitary hospitals. For all the cases a controlled histological study was performed by a dermatopathologist expert and immuno-histochemistry was added...
August 2015: Annales de Pathologie
S Kitamura, H Hata, Y Inamura, K Imafuku, T Sakashita, K Hirata, H Shimizu
Primary mucinous carcinoma of the skin (PMCS) is a rare cutaneous malignant neoplasm; its regional node metastasis is also rare. Currently, positron emission tomography-computed tomography (PET-CT) is known to be a useful tool to search for early metastatic lesions in various carcinomas. However, PET-CT is not always specific for head and neck lesions because of physiological uptake in the brain, palatine tonsil, salivary gland, thyroid etc. Herein we present two cases of head and neck PMCS in which metastasis was diagnosed accurately by PET-CT...
November 2015: British Journal of Dermatology
Sonia Toussaint-Caire, Adriana Aguilar-Donis, Edoardo Torres-Guerrero, Daniel Asz-Sigall, María Elisa Vega-Memije, Rosa María Lacy-Niebla, Judith Domínguez-Cherit, Patricia Alfaro Ledesma, Carlos Ortiz-Hidalgo
INTRODUCTION: Perineurioma is an infrequent and benign cutaneous neoplasm characterized by proliferation of perineurial cells. It is classified into two main types: intraneural and the extraneural or soft tissue perineurioma, in which the sclerosing variant is included. Sclerosing perineurioma is more frequently found on acral skin. Clinically, they are well-circumscribed,skin colored, nodular tumors. OBJECTIVE: Describe and communicate clinicopathologic findings from a case series of sclerosing acral perineurioma...
May 2015: Gaceta Médica de México
Nancy Cheng, Hadas Skupsky, David S Cassarino
Clear cell proliferations of the skin consist of a diverse group of lesions characterized by the presence of cells with abundant clear cytoplasm. They may arise from primary, metastatic, or non-neoplastic origins, with their distinctive cytoplasmic clearing attributable to causes ranging from artifact to accumulation of materials such as glycogen, mucin, or lipids. Despite the heterogeneity of these lesions, their distinguishing characteristics may be subtle, especially at high power. As such, histologic diagnosis can be challenging, and proper consideration relies on an understanding of the scope of possible origins, etiologies, and key immunohistochemical staining patterns of the various entities...
May 2015: Advances in Anatomic Pathology
Joshua L Owen, Andrew P Word, Travis Vandergriff, Seemal R Desai
Plaque-like cutaneous mucinosis (PCM) is a rare disorder of dermal mucin deposition. Some patients with PCM will be found to have an associated malignancy. We report the case of a 72-year-old man presenting with new onset pruritic, waxy-appearing erythematous and skin-colored papules and nodules coalescing into plaques on his shoulder, scalp, and forehead. Skin biopsy revealed cutaneous mucinosis. Despite conservative treatment, his skin lesions progressed, and he was found to have an occult malignancy of pancreatobiliary origin...
February 2015: Dermatology Online Journal
Alexandra Junewicz, John Heaphy, Pierre Lavertu, Jay Wasman, Devra Becker
Primary cutaneous mucoepidermoid carcinoma remains a rare occurrence. This is the first report of a case of primary cutaneous mucoepidermoid carcinoma originating on the scalp and subsequently metastasizing to the parotid gland. The patient was a 53-year-old female who presented with a purple mass on her scalp since 5 months prior to examination. Histopathology revealed nests and islands of atypical epithelioid cells with pleomorphism, medium to prominent nucleoli, and scattered mucin deposition highlighting with a mucicarmine stain...
May 2015: American Journal of Otolaryngology
Aleksandra Lesiak, Marcin Włodarczyk, Aleksandra Sobolewska, Joanna Sieniawska, Michał Rogowski-Tylman, Anna Sysa-Jedrzejowska, Irmina Olejniczak-Staruch, Joanna Narbutt
Skin mucinosis is a rare skin disease which clinically manifests as firm papules and waxy nodules. We report a case of a 66-year-old female psoriatic patient who developed skin mucinosis during biological therapy. Because of a previous lack of response to the local and conventional systemic treatment of psoriasis, the patient received biological therapy (infliximab from June 2008 to May 2009 - initial clinical improvement and loss of treatment effectiveness in the 36(th) week of the therapy; adalimumab from June 2009 to January 2010 - lack effectiveness; ustekinumab from March 2012 to the present)...
December 2014: Postȩpy Dermatologii i Alergologii
Shabnam Momtahen, Gerard J Nuovo, Cynthia M Magro
Mycosis fungoides (MF), the most common form of cutaneous lymphoma is derived from postthymic T cells that migrate to the skin likely under the influence of chronic antigen stimulation. Less common histomorphologic variants are diagnostically challenging because of their resemblance to reactive conditions. Three men aged 46, 73, and 74 years and one 83-year-old woman were encountered in the files of one of the authors and represented the patients. The patients had a longstanding eruption for several years. In 2 cases, the clinical course was aggressive with extracutaneous lymph node and/or peripheral blood dissemination...
September 2015: American Journal of Dermatopathology
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