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https://www.readbyqxmd.com/read/29341837/ocular-permeation-of-topical-tazocin-and-its-effectiveness-in-the-treatment-of-pseudomonas-aeruginosa-induced-keratitis-in-rabbits
#1
Sujaya Singh, Renu Agarwal, Zulhilmi Abdul Razak, Robin Ngu, Lwin L Nyein, Sushil Vasudevan, Marina Kapitonova, Azida Juana Kadir, Subrayan Visvaraja
PURPOSE: Pseudomonas aeruginosa is the most common causative organism for contact lens-associated corneal ulcer and is commonly treated with fluoroquinolones. With the emergence of resistant strains, it is important to investigate alternative therapies. Despite well-established efficacy of tazocin against systemic Pseudomonas infections, its topical use for the treatment of Pseudomonas keratitis has not been described, hence this study was aimed to find the ocular permeation of Tazocin and its efficacy in treating keratitis in rabbit eyes...
January 17, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29338030/incidence-microbiology-and-outcomes-of-endophthalmitis-after-111-876-pars-plana-vitrectomies-at-a-single-tertiary-eye-care-hospital
#2
Muna Bhende, Rajiv Raman, Mukesh Jain, Pratik K Shah, Tarun Sharma, Lingam Gopal, Pramod S Bhende, Sangeetha Srinivasan, Malathi Jambulingam
PURPOSE: To describe the incidence, risk factors, clinical presentation, causative organisms, and outcomes in patients with endophthalmitis following pars plana vitrectomy (20G and minimally invasive vitrectomy surgery (MIVS). METHODS: Of 111,876 vitrectomies (70,585 20-G 41,291 MIVS) performed, 45 cases developed acute-onset, postoperative endophthalmitis. RESULTS: The rate of culture positive and culture negative endophthalmitis was 0.021% (2...
2018: PloS One
https://www.readbyqxmd.com/read/29336564/benzophenone-4-promotes-the-growth-of-a-pseudomonas-sp-and-biogenic-oxidation-of-mn-ii
#3
Yangyang Chang, Yaohui Bai, Yang Huo, Jiuhui Qu
Interactions between microbes and micropollutants (MPs) play a crucial role in water purification or treatment. Current studies have generally focused on the direct degradation or co-metabolism of MPs. Considering the increasing interest in and importance of the roles of MPs in microbial metabolism, we adopted a Mn(II)-oxidizing Pseudomonas sp. QJX-1 using tyrosine (Tyr) as the sole carbon and nitrogen source to investigate the effects of seven MPs on its growth and function. Six MPs exhibited an inhibition effect on bacterial growth and Mn(II) oxidation...
January 16, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29336141/label-free-optical-biodetection-of-pathogen-virulence-factors-in-complex-media-using-microtoroids-with-multifunctional-surface-functionality
#4
Pelin Toren, Erol Ozgur, Mehmet Bayindir
Early detection of pathogens or their virulence factors in complex media has a key role in early diagnosis and treatment of many diseases. Nano-molar and selective detection of Exotoxin A, which is a virulence factor secreted from Pseudomonas aeruginosa in the sputum of Cystic Fibrosis (CF) patients, can pave the way for early diagnosis of P. aeruginosa infections. In this study, we conducted a preliminary study to demonstrate the feasibility of optical biodetection of P. aeruginosa Exotoxin A in a diluted artificial sputum mimicking the CF respiratory environment...
January 16, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29335216/a-new-screened-microbial-consortium-oem2-for-lignocellulosic-biomass-deconstruction-and-chlorophenols-detoxification
#5
Jiajin Liang, Xiuxiu Fang, Yunqin Lin, Dehan Wang
Recalcitrance limits biomass application in biorefinery. It is even more so when toxic chlorophenols are present. In this study, we screened a microbial consortium, OEM2, for lignocellulose deconstruction and chlorophenols detoxification through a short-term and efficient screening process. Microbial consortium OEM2 had a good buffer capability in the cultivation process and exhibited a high xylanase activity, with over 85% hemicellulose degradation within 12 days. Throughout the treatment process, 41.5% rice straw decomposition on day 12 and around 75% chlorophenols (MCP, 2,4-DCP, 2,4,6-TCP) removal on day 9, were recorded...
January 11, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29331660/persistent-contamination-of-heater-cooler-units-for-extracorporal-circulation-cured-by-chlorhexidine-alcohol-in-water-tanks
#6
Sara Romano-Bertrand, Marine Evrevin, Chloé Dupont, Jean-Marc Frapier, Jean-Claude Sinquet, Elodie Bousquet, Bernard Albat, Estelle Jumas-Bilak
Recently, surgical site infections due to non-tuberculous Mycobacterium (NTM) have been linked to heater-cooler units (HCUs) contamination. ECDC and manufacturers now recommend the use of hydrogen peroxide in filtered water to fill HCU tanks. After implementation of these measures in our hospital, HCUs became heavily contaminated by opportunistic waterborne pathogens such as Pseudomonas aeruginosa and Stenotrophomonas maltophilia. No NTM were detected but fast-growing resistant bacteria could impair their detection...
January 10, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29329376/soil-microbial-species-loss-affects-plant-biomass-and-survival-of-an-introduced-bacterial-strain-but-not-inducible-plant-defences
#7
Viola Kurm, Wim H van der Putten, Ana Pineda, W H Gera Hol
Background and Aims: Plant growth-promoting rhizobacteria (PGPR) strains can influence plant-insect interactions. However, little is known about the effect of changes in the soil bacterial community in general and especially the loss of rare soil microbes on these interactions. Here, the influence of rare soil microbe reduction on induced systemic resistance (ISR) in a wild ecotype of Arabidopsis thaliana against the aphid Myzus persicae was investigated. Methods: To create a gradient of microbial abundances, soil was inoculated with a serial dilution of a microbial community and responses of Arabidopsis plants that originated from the same site as the soil microbes were tested...
January 10, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29328931/biostimulation-and-bioaugmentation-of-native-microbial-community-accelerated-bioremediation-of-oil-refinery-sludge
#8
Ajoy Roy, Avishek Dutta, Siddhartha Pal, Abhishek Gupta, Jayeeta Sarkar, Ananya Chatterjee, Anumeha Saha, Poulomi Sarkar, Pinaki Sar, Sufia K Kazy
Scope for developing an engineered bioremediation strategy for the treatment of hydrocarbon-rich petroleum refinery waste was investigated through biostimulation and bioaugmentation approaches. Enhanced (46-55%) total petroleum hydrocarbon (TPH) attenuation was achieved through phosphate, nitrate or nitrate+phosphate amendment in the sludge with increased (upto 12%) abundance of fermentative, hydrocarbon degrading, sulfate-reducing, CO2-assimilating and methanogenic microorganisms (Bacillus, Coprothermobacter, Rhodobacter, Pseudomonas, Achromobacter, Desulfitobacter, Desulfosporosinus, T78, Methanobacterium, Methanosaeta, etc)...
January 3, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29324651/incidence-microbiological-profile-and-risk-factors-of-healthcare-associated-infections-in-intensive-care-units-a-10-year-observation-in-a-provincial-hospital-in-southern-poland
#9
Małgorzata Kołpa, Marta Wałaszek, Agnieszka Gniadek, Zdzisław Wolak, Wiesław Dobroś
Healthcare-associated infections (HAIs) occurring in patients treated in an intensive care unit (ICU) are serious complications in the treatment process. Aetiological factors of these infections can have an impact on treatment effects, treatment duration and mortality. The aim of the study was to determine the prevalence and microbiological profile of HAIs in patients hospitalized in an ICU over a span of 10 years. The active surveillance method was used to detect HAIs in adult patients who spent over 48 h in a general ICU ward located in southern Poland between 2007 and 2016...
January 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29322006/attenuation-of-quorum-sensing-dependent-virulence-factors-and-biofilm-formation-by-medicinal-plants-against-antibiotic-resistant-pseudomonas-aeruginosa
#10
P Sankar Ganesh, V Ravishankar Rai
Pseudomonas aeruginosa use small signaling molecules such as acyl homoserine lactones (AHLs), which play an important role in release virulence factors and toxin for further establishment of host infection. Thus, involving with the QS system would provide alternative ways of preventing the pathogenicity. In the present study, totally six medicinal plants (Terminalia bellerica, Celastrus paniculatus, Kingiodendron pinnatum, Schleichera oleosa, Melastoma malabathricum, Garcinia gummi-gutta) were screened for anti-QS activity using biomonitor strain of Chromobacterium violaceum CV12472...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321384/discovery-of-a-novel-fluoroquinolone-antibiotic-candidate-wfq-228-with-potent-antimicrobial-activity-and-the-potential-to-overcome-major-drug-resistance
#11
Tatsuya Hirano, Tomohiko Kinoshita, Daichi Kazamori, Satoshi Inoue, Kouji Nishimura, Asuka Sakurai, Kensuke Ohishi, Yasuhiro Kuramoto, Hirotaka Amano, Akira Yazaki
WFQ-101 with a unique N-1 substituent, 5-amino-4-fluoro-2-(hydroxymethyl)phenyl group, was selected as a lead compound through combination screening based on antimicrobial activity and the efflux index against quinolone-resistant (QR) Pseudomonas aeruginosa (P. aeruginosa). Through structural optimization, we identified WFQ-228 as a novel fluoroquinolone antibiotic candidate. WFQ-228 had potent and superior activity in comparison to levofloxacin (LVX) and ciprofloxacin (CIP) against clinical isolates of P. aeruginosa, Escherichia coli and Acinetobacter baumannii, including QR strains...
January 11, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29321301/plasmid-stability-is-enhanced-by-higher-frequency-pulses-of-positive-selection
#12
Cagla Stevenson, James P J Hall, Michael A Brockhurst, Ellie Harrison
Plasmids accelerate bacterial adaptation by sharing ecologically important traits between lineages. However, explaining plasmid stability in bacterial populations is challenging owing to their associated costs. Previous theoretical and experimental studies suggest that pulsed positive selection may explain plasmid stability by favouring gene mobility and promoting compensatory evolution to ameliorate plasmid cost. Here we test how the frequency of pulsed positive selection affected the dynamics of a mercury-resistance plasmid, pQBR103, in experimental populations of Pseudomonas fluorescens SBW25...
January 10, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29320769/electronic-nose-in-the-detection-of-wound-infection-bacteria-from-bacterial-cultures-a-proof-of-principle-study
#13
Taavi Saviauk, Juha P Kiiski, Maarit K Nieminen, Nelly N Tamminen, Antti N Roine, Pekka S Kumpulainen, Lauri J Hokkinen, Markus T Karjalainen, Risto E Vuento, Janne J Aittoniemi, Terho J Lehtimäki, Niku K Oksala
BACKGROUND: Soft tissue infections, including postoperative wound infections, result in a significant burden for modern society. Rapid diagnosis of wound infections is based on bacterial stains, cultures, and polymerase chain reaction assays, and the results are available earliest after several hours, but more often not until days after. Therefore, antibiotic treatment is often administered empirically without a specific diagnosis. METHODS: We employed our electronic nose (eNose) system for this proof-of-concept study, aiming to differentiate the most relevant bacteria causing wound infections utilizing a set of clinical bacterial cultures on identical blood culture dishes, and established bacterial lines from the gaseous headspace...
January 10, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29319507/inhibition-of-multidrug-resistant-gram-positive-and-gram-negative-bacteria-by-a-photoactivated-porphyrin
#14
Moreno Bondi, Anna Mazzini, Simona de Niederhäusern, Ramona Iseppi, Patrizia Messi
The authors studied the in vitro antibacterial activity of the photo-activated porphyrin meso-tri(N-methyl-pyridyl), mono(N-tetradecyl-pyridyl)porphine (C14) against four multidrug-resistant bacteria: Staphylococcus aureus, Enterococcus faecalis (Gram-positive), Escherichia coli, Pseudomonas aeruginosa (Gram-negative). Using 10 μg/ml of porphyrin and 60 sec irradiation we observed the remarkable susceptibility of S. aureus and E. faecalis to treatment while, under the same conditions, E. coli and P. aeruginosa showed very low susceptibility...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29317840/an-antibiotic-stewardship-exercise-in-the-icu-building-a-treatment-algorithm-for-the-management-of-ventilator-associated-pneumonia-based-on-local-epidemiology-and-the-2016-infectious-diseases-society-of-america-american-thoracic-society-guidelines
#15
Lyn S Awad, Dania I Abdallah, Anas M Mugharbil, Tamima H Jisr, Nabila S Droubi, Nabila A El-Rajab, Rima A Moghnieh
Introduction: Management of ventilator-associated pneumonia (VAP), the most common infection in patients on mechanical ventilation, should be tailored to local microbiological data. The aim of this study was to determine susceptibility patterns of organisms causing VAP to develop a treatment algorithm based on these findings and evidence from the literature. Materials and methods: This is a retrospective analysis of the microbiological etiology of VAP in the intensive care unit (ICU) of a Lebanese tertiary care hospital from July 2015 to July 2016...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29316554/skin-infections-due-to-bacteria-in-solid-organ-transplant-recipients-a-review
#16
Muneeb Ilyas, Nishita Maganty, Zachary Ginsberg, Amit Sharma
Though there is an abundance of information on cutaneous malignancies in transplant recipients, cutaneous infections in solid organ transplant recipients (SOTRs) are underrepresented in the dermatological literature. Our paper provides a comprehensive review of bacterial cutaneous infections within the solid organ transplant population. Cutaneous bacterial infections may lead to significant morbidity and even mortality in this immunosuppressed population. Thus, it is to the benefit of both dermatologists and other transplant care providers to better understand and recognize the features of cutaneous bacterial infections in SOTRs...
January 10, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29315274/synthesized-heparan-sulfate-competitors-attenuate-pseudomonas-aeruginosa-lung-infection
#17
Nicola Ivan Lorè, Noemi Veraldi, Camilla Riva, Barbara Sipione, Lorenza Spagnuolo, Ida De Fino, Medede Melessike, Elisa Calzi, Alessandra Bragonzi, Annamaria Naggi, Cristina Cigana
Several chronic respiratory diseases are characterized by recurrent and/or persistent infections, chronic inflammatory responses and tissue remodeling, including increased levels of glycosaminoglycans which are known structural components of the airways. Among glycosaminoglycans, heparan sulfate (HS) has been suggested to contribute to excessive inflammatory responses. Here, we aim at (i) investigating whether long-term infection by Pseudomonas aeruginosa, one of the most worrisome threat in chronic respiratory diseases, may impact HS levels, and (ii) exploring HS competitors as potential anti-inflammatory drugs during P...
January 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29312739/the-role-of-bacterial-culture-by-bronchoscopy-in-patients-with-lung-cancer-a-prospective-study
#18
Matthew Koslow, Gali Epstein Shochet, Alona Matveychuk, Lilach Israeli-Shani, Alexander Guber, David Shitrit
Background: Patients with lung cancer undergoing surgical and medical treatment are at increased risk for pulmonary complications. The importance of routine bronchoscopy procedure in populations with lung cancer has rarely been defined. We aimed to determine the growth of potentially pathogenic microorganisms (PPM) among patients evaluated by bronchoscopy for lung cancer. Methods: This prospective study included 155 consecutive patients with lung mass or radiologic findings suspicious for malignancy...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29311081/antimicrobial-activity-of-ibuprofen-against-cystic-fibrosis-associated-gram-negative-pathogens
#19
Parth N Shah, Kimberly R Marshall-Batty, Justin A Smolen, Jasur A Tagaev, Qingquan Chen, Christopher A Rodesney, Henry H Le, Vernita D Gordon, David E Greenberg, Carolyn L Cannon
Clinical trials have demonstrated the benefits of ibuprofen therapy in cystic fibrosis (CF) patients, an effect that is currently attributed to ibuprofen's anti-inflammatory properties. Yet, a few previous reports demonstrate an antimicrobial activity of ibuprofen as well, although none investigate its direct effects on the pathogens found in the CF lung, which is the focus of this work. Determination of ibuprofen's in vitro antimicrobial activity against Pseudomonas aeruginosa and Burkholderia spp. strains through measurements of endpoint colony-forming units (CFU) and growth kinetics showed that ibuprofen reduces the growth rate and bacterial burden of tested strains in a dose-dependent fashion...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29310905/role-of-airway-glucose-in-bacterial-infections-in-patients-with-chronic-obstructive-pulmonary-disease
#20
Patrick Mallia, Jessica Webber, Simren K Gill, Maria-Belen Trujillo-Torralbo, Maria Adelaide Calderazzo, Lydia Finney, Eteri Bakhsoliani, Hugo Farne, Aran Singanayagam, Joseph Footitt, Richard Hewitt, Tatiana Kebadze, Julia Aniscenko, Vijay Padmanaban, Philip L Molyneaux, Ian M Adcock, Peter J Barnes, Kazihuro Ito, Sarah L Elkin, Onn Min Kon, William O Cookson, Miriam F Moffat, Sebastian L Johnston, John S Tregoning
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) have increased susceptibility to respiratory tract infection, which contributes to disease progression and mortality, but mechanisms of increased susceptibility to infection remain unclear. OBJECTIVES: The aim of this study was to determine whether glucose concentrations were increased in airway samples (nasal lavage fluid, sputum, and bronchoalveolar lavage fluid) from patients with stable COPD and to determine the effects of viral infection on sputum glucose concentrations and how airway glucose concentrations relate to bacterial infection...
December 13, 2017: Journal of Allergy and Clinical Immunology
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