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https://www.readbyqxmd.com/read/29052142/infection-of-kshv-and-interaction-with-hiv-the-bad-romance
#1
Jie Qin, Chun Lu
Kaposi's sarcoma-associated herpesvirus (KSHV), namely, human herpesvirus 8 (HHV-8), is considered as the pathogen of Kaposi's sarcoma (KS), the most frequent cancer in untreated HIV-infected individuals. Patients infected with HIV have a much higher possibility developing KS than average individual. Researchers have found that HIV, which functions as a cofactor of KS, contributes a lot to the development of KS. In this article, we will give a brief introduction of KS and KSHV and how the interaction between KSHV and HIV contributes to the development of KS...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29052134/kaposi-s-sarcoma-associated-herpesvirus-epidemiology-and-molecular-biology
#2
Shasha Li, Lei Bai, Jiazhen Dong, Rui Sun, Ke Lan
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8 (HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human oncogenic virus. Since its discovery in AIDS-associated KS tissues by Drs. Yuan Chang and Patrick Moore, much progress has been made in the past two decades. There are four types of KS including classic KS, endemic KS, immunosuppressive therapy-related KS, and AIDS-associated KS. In addition to KS, KSHV is also involved in the development of primary effusion lymphoma (PEL) and certain types of multicentric Castleman's disease...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29052098/comparative-transcriptome-analysis-reveals-whole-genome-duplications-and-gene-selection-patterns-in-cultivated-and-wild-chrysanthemum-species
#3
So Youn Won, Soo-Jin Kwon, Tae-Ho Lee, Jae-A Jung, Jung Sun Kim, Sang-Ho Kang, Seong-Han Sohn
Comparative transcriptome analysis of wild and cultivated chrysanthemums provides valuable genomic resources and helps uncover common and divergent patterns of genome and gene evolution in these species. Plants are unique in that they employ polyploidy (or whole-genome duplication, WGD) as a key process for speciation and evolution. The Chrysanthemum genus is closely associated with hybridization and polyploidization, with Chrysanthemum species exhibiting diverse ploidy levels. The commercially important species, C...
October 19, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/29051178/tlr4-mediated-inflammation-promotes-kshv-induced-cellular-transformation-and-tumorigenesis-by-activating-the-stat3-pathway
#4
Marion Gruffaz, Karthik Vasan, Brandon Tan, Suzane Ramos da Silva, Shou-Jiang Gao
Toll-like receptors (TLR) are conserved immune sensors mediating antimicrobial and antitumoral responses, but recent evidence implicates them in promoting carcinogenesis in certain cancers. Kaposi's sarcoma (KS) is caused by infection of Kaposi's sarcoma-associated herpesvirus (KSHV) and is characterized by uncontrolled neoangiogenesis and inflammation. Here we show that TLR4 is upregulated in KSHV-infected spindle tumor cells in human KS lesions. In a model of KSHV-induced cellular transformation, KSHV upregulated expression of TLR4, its adaptor MyD88, and coreceptors CD14 and MD2...
October 19, 2017: Cancer Research
https://www.readbyqxmd.com/read/29042615/roles-of-bulk-and-surface-magnetic-anisotropy-on-the-longitudinal-spin-seebeck-effect-of-pt-yig
#5
Vijaysankar Kalappattil, Raja Das, Manh-Huong Phan, Hariharan Srikanth
A clear understanding of the temperature evolution of the longitudinal spin Seebeck effect (LSSE) in the classic Pt/yttrium iron garnet (YIG) system and its association with magnetic anisotropy is essential towards optimization of its spin-caloric functionality for spintronics applications. We report here for the first time the temperature dependences of LSSE voltage (V LSSE), magnetocrystalline anisotropy field (H K) and surface perpendicular magnetic anisotropy field (H KS) in the same Pt/YIG system. We show that on lowering temperature, the sharp drop in V LSSE and the sudden increases in H K and H KS at ~175 K are associated with the spin reorientation due to single ion anisotropy of Fe(2+) ions...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042509/properties-of-real-metallic-surfaces-effects-of-density-functional-semilocality-and-van-der-waals-nonlocality
#6
Abhirup Patra, Jefferson E Bates, Jianwei Sun, John P Perdew
We have computed the surface energies, work functions, and interlayer surface relaxations of clean (111), (100), and (110) surfaces of Al, Cu, Ru, Rh, Pd, Ag, Pt, and Au. We interpret the surface energy from liquid metal measurements as the mean of the solid-state surface energies over these three lowest-index crystal faces. We compare experimental (and random phase approximation) reference values to those of a family of nonempirical semilocal density functionals, from the basic local density approximation (LDA) to our most advanced general purpose meta-generalized gradient approximation, strongly constrained and appropriately normed (SCAN)...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29038765/the-complete-chloroplast-genome-sequence-of-strawberry-fragaria-%C3%A2-%C3%A3-%C3%A2-ananassa-duch-and-comparison-with-related-species-of-rosaceae
#7
Hui Cheng, Jinfeng Li, Hong Zhang, Binhua Cai, Zhihong Gao, Yushan Qiao, Lin Mi
Compared with other members of the family Rosaceae, the chloroplast genomes of Fragaria species exhibit low variation, and this situation has limited phylogenetic analyses; thus, complete chloroplast genome sequencing of Fragaria species is needed. In this study, we sequenced the complete chloroplast genome of F. × ananassa 'Benihoppe' using the Illumina HiSeq 2500-PE150 platform and then performed a combination of de novo assembly and reference-guided mapping of contigs to generate complete chloroplast genome sequences...
2017: PeerJ
https://www.readbyqxmd.com/read/29037857/exploring-the-role-of-il-32-in-human-immunodeficiency-virus-related-kaposi-sarcoma
#8
George Semango, Bas Heinhuis, Theo S Plantinga, Willeke A M Blokx, Gibson Kibiki, Tolbert Sonda, Daudi Mavura, Elisante John Masenga, Mramba Nyindo, Andre J A M van der Ven, Leo A B Joosten
The intracellular pro-inflammatory mediator interleukin (IL)-32 is associated with tumor progression; however, the mechanisms remain unknown. We studied the IL-32 mRNA expression as well as other pro-inflammatory cytokines and mediators including IL-1α, IL-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, the pro-angiogenic and anti-apoptotic enzyme COX-2, the IL-8 receptor CXCR1, and the intracellular kinase FAK-1. The interaction of IL-32 expression with expression of IL-6, TNFα, IL-8, and COX-2 was also investigated...
October 13, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29035418/multi-criteria-evaluation-of-hydro-geological-and-anthropogenic-parameters-for-the-groundwater-vulnerability-assessment
#9
Prashant Kumar, Praveen K Thakur, Baban Ks Bansod, Sanjit K Debnath
Groundwater contamination assessment is a challenging task due to inherent complex dynamisms associated with the groundwater. DRASTIC is a very widely used rapid regional tool for the assessment of vulnerability of groundwater to contamination. DRASTIC has many lacunas in the form of subjectivities associated with weights and ratings of its hydro-geological parameters, and, therefore, the accuracy of the DRASTIC-based vulnerability map is questioned. The present study demonstrates the optimisation of the DRASTIC parameters along with a scientific consideration to the anthropogenic factors causing groundwater contamination...
October 16, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29035110/early-communicative-skills-of-children-with-klinefelter-syndrome
#10
Laura Zampini, Tiziana Burla, Gaia Silibello, Francesca Dall'Ara, Claudia Rigamonti, Faustina Lalatta, Paola Vizziello
Many studies reported the presence of language impairments in children and adolescents with Klinefelter syndrome (KS). However, the first stage of their language development has been scarcely studied. The present study aimed to describe the spontaneous communicative production of 18-month-old children with KS, in comparison with that of typically developing (TD) male peers, aiming to verify the existence of different early communicative skills in both vocal and gestural modality and to identify the presence of possible associations with their later vocabulary size...
October 16, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/29031103/kaposi-s-sarcoma-herpesvirus-induced-endothelial-cell-reprogramming-supports-viral-persistence-and-contributes-to-kaposi-s-sarcoma-tumorigenesis
#11
REVIEW
Silvia Gramolelli, Päivi M Ojala
Kaposi's sarcoma (KS) is an endothelial tumor causally linked to Kaposi's sarcoma herpesvirus (KSHV) infection. At early stages of KS, inflammation and aberrant neoangiogenesis are predominant, while at late stages the disease is characterized by the proliferation of KSHV-infected spindle cells (SC). Since KSHV infection modifies the endothelial cell (EC) identity, the origin of SCs remains elusive. Yet, pieces of evidence indicate the lymphatic origin. KSHV-infected ECs display increased proliferative, angiogenic and migratory capacities which account for KS oncogenesis...
October 11, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/29030589/aberrant-ocular-architecture-and-function-in-patients-with-klinefelter-syndrome
#12
Cristin Brand, Michael Zitzmann, Nicole Eter, Sabine Kliesch, Joachim Wistuba, Maged Alnawaiseh, Peter Heiduschka
Klinefelter Syndrome (KS), the most common chromosomal disorder in men (47,XXY), is associated with numerous comorbidities. Based on a number of isolated case reports, we performed the first systematic and comprehensive evaluation of eye health in KS patients with a focus on ocular structure and vascularization. Twenty-one KS patients and 26 male and 38 female controls underwent a variety of non-invasive examinations investigating ocular morphology (examination of retinal thickness, optic nerve head, and cornea) and function (visual field testing and quantification of ocular vessel density by optical coherence tomography angiography)...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29027201/phototrophic-cultivation-of-nacl-tolerant-mutant-of-spirulina-platensis-for-enhanced-c-phycocyanin-production-under-optimized-culture-conditions-and-its-dynamic-modelling
#13
Apurva Gupta, Devendra Mohan, Rishi Kumar Saxena, Surendra Singh
Commercial cultivation of Spirulina sp. is highly popular due to the presence of high amount of C-phycocyanin (C-PC) and other valuable chemicals like carotenoids and γ-linolenic acid. In this study, the pH and the concentrations of nitrogen and carbon source were manipulated to achieve the improved cell growth and C-PC production in NaCl-tolerant mutant of Spirulina platensis. In the present study, highest C-PC (147 mg · L(-1) ) and biomass (2.83 g · L(-1) ) production was achieved when NaCl tolerant mutant of S...
October 13, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/29022642/induction-of-puberty-with-human-chorionic-gonadotropin-hcg-followed-by-reversal-of-hypogonadotropic-hypogonadism-in-kallmann-syndrome
#14
Malgorzata Maria Pierzchlewska, Maciej Grzegorz Robaczyk, Ida Vogel
INTRODUCTION: Kallmann syndrome (KS) is a rare, congenital disorder combining hypogonadotropic hypogonadism (HH) due to GnRH-deficiency with anosmia. Traditionally thought to require lifelong therapy it turns out to be a reversible condition in some patients. CASE REPORT: We present a case of a 22-year old man with absent puberty due to KS, in whom genetic testing revealed heterozygosity for a mutation in the PROK2 gene. Pubertal development and virilisation was achieved by using human chorionic gonadotropin (hCG) injections followed by testosterone replacement...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022558/klinefelter-syndrome-in-childhood-variability-in-clinical-and-molecular-findings
#15
Neşe Akcan, Şükran Poyrazoğlu, Firdevs Baş, Rüveyde Bundak, Feyza Darendeliler
OBJECTIVE: Klinefelter syndrome (KS) is the most common (1/500-1/1000) chromosomal disorder in males, but only 10% of cases are identified in childhood. This study aimed to review the data of the children with KS to assess the age and reason for diagnosis, clinical and laboratory findings, as well as the presence of comorbidities. METHODS: Twenty-three KS patients were analyzed retrospectively. Age at admission, presenting symptoms, comorbid problems, height, weight, pubertal status, biochemical findings, hormone profiles, bone mineral density, and karyotype were evaluated...
October 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29022531/survival-of-patients-with-kaposi-s-sarcoma-in-the-south-african-antiretroviral-treatment-era-a-retrospective-cohort-study
#16
M M Sengayi, D Kielkowski, M Egger, L Dreosti, J Bohlius
BACKGROUND: When South Africa (SA) implemented its antiretroviral therapy (ART) programme in 2004, the model for treating HIV-positive Kaposi's sarcoma (KS) patients shifted from symptomatic palliation to potential cure. OBJECTIVE: To evaluate survival and changes over time in AIDS-KS patients treated at a tertiary academic hospital oncology unit (the Steve Biko Academic Hospital medical oncology unit) in Pretoria, SA, in the context of ART availability in SA. METHODS: We conducted a retrospective review of electronic and paper records of KS patients who accessed cancer care between May 2004 and September 2012...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29021488/aerobic-dechlorination-of-dichloromethane-using-biostimulation-agent-bd-c-in-continuous-and-batch-cultures-of-xanthobacter-autotrophicus-gj10
#17
Akifumi Hosoda, Yuta Isomura, Syungo Takeo, Takuho Onai, Kazutaka Takeuchi, Minoru Toda, Hiroto Tamura
It is important to construct microbiological treatment systems for organic solvent-contaminated water. We developed a continuous culture supplemented with a biostimulation agent named BD-C, which is formulated from canola oil, and Xanthobacter autotrophicus strain GJ10 for an aerobic dichloromethane (DCM)-dechlorinating microorganism. The continuous culture was a chemostat constructed using a 1 L screw-capped bottle containing artificial wastewater medium with 2.0 mM DCM and 1.0% (v/v) BD-C. The expression of genes for DCM metabolism in the dechlorinating aerobe was monitored and analyzed by reverse transcription-quantitative PCR...
October 11, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/29018155/clinical-characteristics-of-138-chinese-female-patients-with-idiopathic-hypogonadotropic-hypogonadism
#18
Rui-Yi Tang, Rong Chen, Miao Ma, Shou-Qing Lin, Yi-Wen Zhang, Ya-Ping Wang
OBJECTIVE: To evaluate the clinical features of Chinese women with idiopathic hypogonadotropic hypogonadism (IHH). METHODS: We retrospectively reviewed the clinical characteristics, laboratory and imaging findings, therapeutic management, and fertility outcomes of 138 women with IHH. All patients had been treated and followed-up at an academic medical centre during 1990-2016. RESULTS: Among the 138 patients, 82 patients (59.4%) were diagnosed with normosmic IHH and 56 patients (40...
October 10, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29018115/kaposi-s-sarcoma-associated-herpesvirus-increases-pd-l1-and-proinflammatory-cytokine-expression-in-human-monocytes
#19
Kurtis M Host, Sarah R Jacobs, John A West, Zhigang Zhang, Lindsey M Costantini, Charles M Stopford, Dirk P Dittmer, Blossom Damania
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with the human malignancy Kaposi's sarcoma and the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman's disease. KSHV establishes lytic infection of monocytes in vivo, which may represent an important cellular reservoir during KS disease progression. KS tumors consist of latently infected endothelial cells; however, lytic phase gene products are important for KS onset. Early KS lesion progression is driven by proinflammatory cytokines supplied by immune cell infiltrates including T cells and monocytes...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/28992906/renal-amyloidosis-associated-with-kartagener-syndrome-in-a-dog
#20
Bartolo Celona, Chiara Crinò, Carmelo Bruno, Simona Di Pietro, Elisabetta Giudice
A 4-year-old cocker spaniel, male, of 12kg body weight was presented because of the onset of polyuria or polydipsia. From the first months of its life, the dog had exhibited constant serous to mucopurulent nasal discharge, productive cough, sneezing, reverse sneezing, otitis, and recurrent episodes of fever. The respiratory signs had been treated several times with antibiotics, without ever achieving a complete resolution. Clinical examination revealed normal rectal temperature (38.3°C), increased respiratory rate (40breaths/min), a copious mucous nasal discharge and right deviation of the heart apex beat (ictus cordis)...
June 2017: Topics in Companion Animal Medicine
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