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Nannan Song, Zhilan Xu, Jing Wang, Qianqian Qin, Haiyang Jiang, Weina Si, Xiaoyu Li
The CONSTANS-LIKE (COL) gene has an important role both in regulation flowering through photoperiodic control and response to abiotic stress. In the present study, we performed a genome-wide analysis of maize COL gene family and identified 19 non-redundant ZmCOL genes, which were unequally distributed on ten maize chromosomes. Analysis of compound phylogenetic tree (maize, sorghum, rice and Arabidopsis) showed high bootstrap, as well as conserved domain and semblable gene structures among members within the same clade, revealing that COL genes in same clade were from the common ancestral and prior to the divergence of monocots and dicots lineages...
June 13, 2018: Gene
Kai Lee Yap, Amy E Knight Johnson, David Fischer, Priscilla Kandikatla, Jacea Deml, Viswateja Nelakuditi, Sara Halbach, George S Jeha, Lindsay C Burrage, Olaf Bodamer, Valeria C Benavides, Andrea M Lewis, Sian Ellard, Pratik Shah, Declan Cody, Alejandro Diaz, Aishwarya Devarajan, Lisa Truong, Siri Atma W Greeley, Diva D De Leó-Crutchlow, Andrew C Edmondson, Soma Das, Paul Thornton, Darrel Waggoner, Daniela Del Gaudio
PURPOSE: Describe the clinical and molecular findings of patients with Kabuki syndrome (KS) who present with hypoglycemia due to congenital hyperinsulinism (HI), and assess the incidence of KS in patients with HI. METHODS: We documented the clinical features and molecular diagnoses of 10 infants with persistent HI and KS via a combination of sequencing and copy-number profiling methodologies. Subsequently, we retrospectively evaluated 100 infants with HI lacking a genetic diagnosis, for causative variants in KS genes...
June 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Da Un Jeong, Ki Moo Lim
BACKGROUND AND AIMS: Although studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac mechanical and electromechanical characteristics. Therefore, we conducted this study to clarify the relevance of the shortening of APD of a cell in relation to the mechanical contraction activity of the heart and the associated risk of arrhythmia...
June 15, 2018: Biomedical Engineering Online
A S Hess, B R Trible, M K Hess, R R R Rowland, J K Lunney, G S Plastow, J C M Dekkers
Genetic and antigenic variability between Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) isolates has encumbered vaccine development. Here, the genetic basis of PRRSV antibody response was assessed using data from experimental infection trials of commercial crossbred weaner pigs across with one of two distinct PRRSV isolates, NVSL-97-7895 (~750 pigs) and KS-2006-72109 (~450 pigs). Objectives were to estimate the genetic parameters of antibody response, measured as the sample to positive ratio (S:P) of PRRSV N-protein specific IgG in serum at 42 days post infection (dpi); assess the relationship of S:P at 42 dpi with serum viremia and growth under infection; and identify genomic regions associated with S:P at 42 dpi...
June 14, 2018: Journal of Animal Science
P Y Billie Au, Caitlin Goedhart, Marcia Ferguson, Jeroen Breckpot, Koenraad Devriendt, Klaas Wierenga, Elizabeth Fanning, Dorothy K Grange, Gail E Graham, Carolina Galarreta, Marilyn C Jones, Usha Kini, Helen Stewart, Jillian S Parboosingh, Antonie D Kline, A Micheil Innes
Au-Kline syndrome (AKS, OMIM 616580) is a multiple malformation syndrome, first reported in 2015, associated with intellectual disability. AKS has been associated with de novo loss-of-function variants in HNRNPK (heterogeneous ribonucleoprotein K), and to date, only four of these patients have been described in the literature. Recently, an additional patient with a missense variant in HNRNPK was also reported. These patients have striking facial dysmorphic features, including long palpebral fissures, ptosis, deeply grooved tongue, broad nose, and down-turned mouth...
June 14, 2018: European Journal of Human Genetics: EJHG
Qiang Li, Mei Yang, Cheng Chen, Chuan Xiong, Xin Jin, Zhigang Pu, Wenli Huang
The medicinal fungus Laetiporus sulphureus is widely distributed worldwide. To screen for molecular markers potentially useful for phylogenetic analyses of this species and related species, the mitochondrial genome of L. sulphureus was sequenced and assembled. The complete circular mitochondrial genome was 101,111 bp long, and contained 38 protein-coding genes (PCGs), 2 rRNA genes, and 25 tRNA genes. Our BLAST search aligned about 6.1 kb between the mitochondrial and nuclear genomes of L. sulphureus, indicative of possible gene transfer events...
June 14, 2018: Scientific Reports
Srividhya Sundaram, Hak Joong Kim, Ruth Bauer, Tawatchai Thongkongkaew, Daniel Heine, Christian Hertweck
Ketosynthase (KS) domains of modular type I polyketide synthases (PKSs) typically catalyze Claisen condensation of acyl and malonyl units to form linear chains. In stark contrast, the KS domain of the rhizoxin PKS branching module installs a β-branch by a Michael-type vinylogous addition, which sets the basis for a pharmacophoric δ-lactone moiety. The precise role of the KS domain was evaluated by site-directed mutagenesis, chemical probes, and biotransformations. Biochemical and kinetic analyses helped dissecting branching and lactonization reactions, and unequivocally assigned the entire reaction sequence to the KS...
June 13, 2018: Angewandte Chemie
X Paredes-Carnero, J Escobar, J M Galdo, J G Babé
Objective: Our purpose was to review senior author results of TKA in patients with extra-articular angular deformities (correction of mechanical axis was performed without an additional procedure for osteotomy). Methods: Results of TKA in nine knees with osteoarthritis and associated extra-articular angular deformity of femur were reviewed retrospectively. This group was compare with a with a control group of 20 patients diagnosed with osteoarthritis that underwent TKA without extra-articular deformity...
April 2018: Journal of Clinical Orthopaedics and Trauma
Zhuyu Niu, Yating Jia, Yuancai Chen, Yongyou Hu, Junfeng Chen, Yuancai Lv
This study constructed a biological-inorganic hybrid system including Pseudomonas putida (P. putida) and bioreduced Pd (0) nanoparticles (NPs), and inspected the influence of bio-nano Pd (0) on the direct electron transfer and phenol biodegradation. Scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM-EDX) showed that bio-nano Pd (0) (~10 nm) were evenly dispersed on the surface and in the periplasm of P. putida. With the incorporation of bio-nano Pd (0), the redox currents of bacteria in the cyclic voltammetry (CV) became higher and the oxidation current increased as the addition of lactate, while the highest increase rates of two electron transfer system (ETS) rates were 63...
June 8, 2018: Ecotoxicology and Environmental Safety
Yana Fu, Xinxin Yu, Giacomo Savini, Jinhai Huang, Hengli Lian, Benhao Song, Qinmei Wang, Yune Zhao
PURPOSE: To compare keratometry and corneal astigmatism measurements obtained by the Verion Image Guided System to those obtained by automated keratometry (IOLMaster), manual keratometry (YZ38, Suzhou 66 visual Polytron Technologies Inc, China), and Scheimpflug imaging (Pentacam HR) in eyes with cataract. METHODS: 149 cataractous eyes of 149 patients were examined and categorized as low astigmatism (<1.0D, N = 50), moderate astigmatism (1.0-2.0D, N = 49), and high astigmatism (>2...
June 11, 2018: Current Eye Research
Ramya Vangipuram, Stephen K Tyring
Kaposi sarcoma (KS) is a rare angioproliferative tumor whose etiology is associated with human herpesvirus 8 (HHV 8). KS lesions typically involve the skin or mucosal surfaces and are characterized by purplish, red-blue, or brown-black macules, papules, and nodules which are prone to bleeding and ulceration. Definitive diagnosis requires biopsy revealing characteristic angioproliferative features. There are four widely recognized types of KS, which are histologically indistinguishable but differ in epidemiology and prognosis...
June 11, 2018: International Journal of Dermatology
Nathalie Rives, Aurélie Rives, Christine Rondanino, Mireille Castanet, Ariane Cuny, Louis Sibert
Spermatozoa have occasionally been identified in ejaculate of adult Klinefelter syndrome (KS) patients but very exceptionally in KS adolescents. Spermatozoa can also be retrieved in testicular tissue of KS adolescents. The testis may also harbor spermatogonia and noncompletely differentiated germ cells. Neither clinical features nor hormonal parameters could predict germ cell recovery in KS adults or adolescents. No predictive factors can actually demonstrate that early diagnosis of KS would allow increasing the chance of sperm retrieval even if it has been suggested that semen quality may decline with age in KS patients...
2018: Endocrine Development
Denis G Artiukhin, Johannes Neugebauer
We present an effective approach for (spin-)density calculations of open-shell molecular complexes that avoid both an overdelocalization of spin densities as often observed in approximate Kohn-Sham-density functional theory (KS-DFT) calculations and an overlocalization of spin densities as may occur in fragment approaches with non-suitable fragment choices. The method is based on the frozen-density embedding formalism and makes use of non-orthogonal, spin-/charge-localized Slater determinants, which provides a basis for qualitatively correct descriptions of intersystem spin-density delocalization...
June 7, 2018: Journal of Chemical Physics
Minwook Park, Dong-Gue Kang, Yu-Jin Choi, Won-Jin Yoon, Jahyeon Koo, Seo-Hee Park, Seokhoon Ahn, Kwang-Un Jeong
To understand the relationship between kinetically controlled hierarchical superstructures and photophysical properties, pyrene-based asymmetric liquid crystal (LC) dendrons (abbreviated as PD) were newly synthesized by covalently attaching a pyrene moiety (P) at a biphenyl-based LC dendritic group (D). The phase transition behavior of PD has been systematically studied with a combined technique of thermal analysis, microscopy, spectroscopy, and scattering analysis. PD formed two different crystalline structures depending on the cooling rate: a stable crystalline phase (Ks , slow cooling) and a metastable crystalline phase (Kms , quenching)...
June 8, 2018: Chemistry: a European Journal
Chung-Yu Wu, Cheng-Hsiang Cheng, Zhi-Xin Chen
In this paper, a 16-channel analog front-end (AFE) electrocorticography signal acquisition circuit for a closed-loop seizure control system is presented. It is composed of 16 input protection circuits, 16 auto-reset chopper-stabilized capacitive-coupled instrumentation amplifiers (AR-CSCCIA) with bandpass filters, 16 programmable transconductance gain amplifiers, a multiplexer, a transimpedance amplifier, and a 128-kS/s 10-bit delta-modulated successive-approximation-register analog-to-digital converter (SAR ADC)...
June 2018: IEEE Transactions on Biomedical Circuits and Systems
Ahmed Abulwefa, Hrvoje Brkić, Zvonimir Kaić
Objective: To investigate the eruption angle of maxillary canine in patients with Klinefelter syndrome (KS) in which high prevalence of palatally displaced canine anomaly (PDC) has been found by clinical assessment. Subjects and Methods: The sample consisted of 37 KS males aged 20-34 years (mean 27 years) and the control group which consisted of 78 healthy males aged 20-27 years (mean 23 years). A pioneer method was used to measure the eruption angle. It was based on determining the topographic construction of mandibular gonion line called GO-GO method on panoramic radiograph...
December 2017: Acta Stomatologica Croatica
Emre Yucel, Stacia DeSantis, Mary A Smith, David S Lopez
The purpose of this study was to determine the association between low-testosterone (total testosterone ≤3 ng/mL) and prevalence of kidney stones (KS) in men 20 years and older, and whether this varies by comorbidities, and race/ethnicity, and age. This was a cross-sectional study with data from the National Health and Nutrition Examination Survey (NHANES) 2011-2012 cycle. We found that men with low-testosterone had 41% lower odds of KS as compared to men without low-testosterone after multivariable adjustment (OR: 0...
June 2018: Preventive Medicine Reports
Kin Sheng Lim, Anurag Garg, Jason Cheng, Kirithika Muthusamy, Laura Beltran-Agullo, Keith Barton
Introduction: To compare the early postoperative hypotony rates and intraocular pressure (IOP) in two groups of eyes using either 23-gauge (23G) or 25-gauge (25G) needle in the creation of the anterior chamber entry tract for Baerveldt tube. The primary outcome measure was incidence of hypotony, and secondary outcome measures included comparison of mean IOP and other early complications. Materials and methods: Ours was a retrospective case review of consecutive patients who underwent 350 mm2 Baerveldt implantation in two units over a 2-year period...
January 2018: Journal of Current Glaucoma Practice
Snehasis Pradhan, Martin Christ, Hans-Joachim Trappe
This article reports the case of a 22-year-old male patient presented with electrocardiographic ST elevation and elevated cardiac biomarkers. The clinical cascade set into events within an hour of administration of a single-dose of amoxicillin on being diagnosed with acute tonsillitis. The case was preliminarily diagnosed and treated according to the acute coronary syndrome protocol, but on performing coronary angiography no abnormalities in the coronary artery were found. Acute myocarditis was excluded in cardiac MRI...
April 2018: Cardiovascular Diagnosis and Therapy
Eduardo R Argaiz, Maria Chavez-Canales, Mauricio Ostrosky-Frid, Alejandro Rodriguez-Gama, Norma Vázquez, Xochiquetzal Gonzalez-Rodriguez, Jesus Garcia-Valdés, Juliette Hadchouel, David H Ellison, Gerardo Gamba
Familial Hyperkalemic Hypertension (FHHt) can be mainly attributed to increased activity of the renal Na+:Cl- cotransporter (NCC), which is caused by altered expression and regulation of the WNK1 and WNK4 kinases. The WNK1 gene gives rise to a kidney-specific isoform that lacks the kinase domain (KS-WNK1), the expression of which occurs primarily in the distal convoluted tubule. The role played by KS-WNK1 in the modulation of the WNK/SPAK/NCC pathway remains elusive. In the present study, we assessed the effect of human KS-WNK1 on NCC activity and on the WNK4-SPAK pathway...
May 30, 2018: American Journal of Physiology. Renal Physiology
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