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https://www.readbyqxmd.com/read/28651154/new-comprehensive-studies-of-a-gold-iii-dithiocarbamate-complex-with-proven-anticancer-properties-aqueous-dissolution-with-cyclodextrins-pharmacokinetics-and-upstream-inhibition-of-the-ubiquitin-proteasome-pathway
#1
Marianna F Tomasello, Chiara Nardon, Valeria Lanza, Giuseppe Di Natale, Nicolò Pettenuzzo, Stefano Salmaso, Danilo Milardi, Paolo Caliceti, Giuseppe Pappalardo, Dolores Fregona
The gold(III)-dithiocarbamate complex AuL12 (dibromo [ethyl-N-(dithiocarboxy-kS,kS')-N-methylglycinate] gold(III)), is endowed with promising in vitro/in vivo antitumor activity and toxicological profile. Here, we report our recent strategies to improve its water solubility and stability under physiological conditions along with our efforts for unravelling its tangled mechanism of action. We used three types of α-cyclodextrins (CDs), namely β-CD, Me-β-CD and HP-β-CD to prepare aqueous solutions of AuL12...
June 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28649271/effect-of-electrochemotherapy-on-human-herpesvirus-8-kinetics-in-classic-kaposi-sarcoma
#2
Noemy Starita, Gianluca Di Monta, Andrea Cerasuolo, Ugo Marone, Anna Maria Anniciello, Gerardo Botti, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
BACKGROUND: Electrochemotherapy (ECT) has shown to be an effective treatment for cutaneous and subcutaneous Kaposi sarcoma (KS) lesions. However, no study has investigated the impact of ECT treatment on the kinetics of human herpesvirus type 8 (HHV8), which is considered the necessary causal agent of KS. We aimed to evaluate HHV8 viral load and expression levels in patients affected by classic KS who received one or more ECT treatments and have been followed semi annually for up to four years...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28648180/kinetic-study-on-anaerobic-oxidation-of-methane-coupled-to-denitrification
#3
Hou Yu, Hiroyuki Kashima, John M Regan, Abid Hussain, Elsayed Elbeshbishy, Hyung-Sool Lee
Monod kinetic parameters provide information required for kinetic analysis of anaerobic oxidation of methane coupled to denitrification (AOM-D). This information is critical for engineering AOM-D processes in wastewater treatment facilities. We first experimentally determined Monod kinetic parameters for an AOM-D enriched culture and obtained the following values: maximum specific growth rate (μmax) 0.121/d, maximum substrate-utilization rate (qmax) 28.8mmol CH4/g cells-d, half maximum-rate substrate concentration (Ks) 83μΜ CH4, growth yield (Y) 4...
September 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28644401/the-investigation-of-electrochemistry-behaviors-of-tyrosinase-based-on-directly-electrodeposited-grapheneon-choline-gold-nanoparticles
#4
Yaping He, Xiaohui Yang, Quan Han, Jianbin Zheng
A novel catechol (CA) biosensor was developed by embedding tyrosinase (Tyr) onto in situ electrochemical reduction graphene (EGR) on choline-functionalized gold nanoparticle (AuNPs-Ch) film. The results of UV-Vis spectra indicated that Tyr retained its original structure in the film, and an electrochemical investigation of the biosensor showed a pair of well-defined, quasi-reversible redox peaks with Epa = -0.0744 V and Epc = -0.114 V (vs. SCE) in 0.1 M, pH 7.0 sodium phosphate-buffered saline at a scan rate of 100 mV/s...
June 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28639749/evaluation-of-the-in%C3%A2-vivo-cosmetic-efficacy-of-the-mfiii-blue-cell-serum-gel-one-and-two-month-test-results
#5
Dina Tukhvatullina, Alain Béguin, Henry Pong, Maria Del Mar Cabarbas, Dmitry Klokol, Mike Ks Chan, Michelle B F Wong
INTRODUCTION: Skin is changing over time showing signs of aging: dryness, increase in visual and tactile roughness, decrease in collagen content and stiffness, and eventually formation of deep and surface wrinkles, and fine lines. METHODS: Eight-week open experimental study was conducted to test efficacy of MFIII Blue Cell Serum Gel. Main criteria to determine product efficacy by following skin biophysical techniques were as follows: skin moisturization, firmness, epidermal and dermal density, skin surface properties and sebum level, reduction in fine lines and wrinkles...
June 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28638838/kaposi-sarcoma-mimicking-acute-flare-of-ulcerative-colitis
#6
Vivek Kumar, Parita Soni, Mohit Garg, Madina Abduraimova, Jonathan Harris
Besides an AIDS-defining illness, Kaposi sarcoma (KS) is also seen in individuals on long-term immunosuppressant therapy. We report KS in a 70-year-old immunocompetent man, which initially mimicked acute flare of ulcerative colitis (UC). He was hospitalized multiple times for complaints of watery diarrhea and tenesmus. Despite treatment with mesalamine, short courses of methylprednisolone, and one dose of infliximab, his symptoms improved only partially. He underwent colonoscopy, which revealed mild active colitis and a mass in the ascending colon...
April 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28633734/cutaneous-hiv-associated-kaposi-sarcoma-a-potential-setting-for-management-by-clinical-observation
#7
Surget V Beatrous, Stratton B Grisoli, Ryan R Riahi, Philip R Cohen
Kaposi sarcoma (KS) is a malignancy of viral etiology whose course ranges from cutaneous limited lesions to fulminant disease with multi-organ involvement. Four clinical variants of the disease exist: classic, endemic, iatrogenic, and epidemic. Iatrogenic and epidemic variants of Kaposi sarcoma develop in the setting of immune suppression. Transplant recipients who develop iatrogenic KS typically demonstrate improvement of lesions following de-escalation of immunosuppressive therapy. Similarly, HIV-infected patients who begin highly active antiretroviral therapy (HAART) experience immune reconstitution, which can induce KS regression...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28633427/genotypic-variation-in-tolerance-to-drought-stress-is-highly-coordinated-with-hydraulic-conductivity-photosynthesis-interplay-and-aquaporin-expression-in-field-grown-mulberry-morus-spp
#8
Kanubothula Sitarami Reddy, Kalva Madhana Sekhar, Attipalli Ramachandra Reddy
Hydraulic conductivity quantifies the efficiency of a plant to transport water from root to shoot and is a major constriction on leaf gas exchange physiology. Mulberry (Morus spp.) is the most economically important crop for sericulture industry. In this study, we demonstrate a finely coordinated control of hydraulic dynamics on leaf gas exchange characteristics in 1-year-old field-grown mulberry genotypes (Selection-13 (S13); Kollegal Local (KL) and Kanva-2 (K2)) subjected to water stress by withholding water for 20 days and subsequent recovery for 7 days...
June 14, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28633378/the-cost-of-avoiding-freezing-in-stems-trade-off-between-xylem-resistance-to-cavitation-and-supercooling-capacity-in-woody-plants
#9
Nadia S Arias, Fabián G Scholz, Guillermo Goldstein, Sandra J Bucci
Stems and leaves of Olea europaea L. (olive) avoid freezing damage by substantial supercooling during the winter season. Physiological changes during acclimation to low temperatures were studied in five olive cultivars. Water relations and hydraulic traits, ice nucleation temperature (INT) and temperatures resulting in 50% damage (LT50) were determined. All cultivars showed a gradual decrease in INT and LT50 from the dry and warm summer to the wet and cold winter in Patagonia, Argentina. During acclimation to low temperatures there was an increase in leaf cell wall rigidity and stomatal conductance (gs), as well as a decrease in leaf apoplastic water content, leaf water potential (Ψ), sap flow and stem hydraulic conductivity (ks)...
June 14, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28631891/no-detectable-human-herpesvirus-8-oral-shedding-in-seronegative-healthy-immunocompetent-individuals-from-non-endemic-regions-for-kaposi-s-sarcoma-a-pilot-study
#10
Tânia R Tozetto-Mendoza, Laura M Sumita, Michelle Palmieri, Mariana Ornaghi, Alan M do Canto, Paulo H Braz-Silva
AIM: Saliva can play an important role in human herpesvirus-8 (HHV-8) transmission in endemic regions for Kaposi's sarcoma (KS). Little is known about HHV-8 oral shedding in immunocompetent individuals from non-endemic regions for KS. METHODS: We conducted a prospective study of HHV-8 salivary excretion among 59 healthy, immunocompetent individuals from São Paulo, Brazil, followed up weekly for 4 months, resulting in 16 saliva samples from each participant. Antibodies to HHV-8 latency-associated nuclear antigen (LANA) and lytic-phase antigens were investigated with immunofluorescence assays (IFA)...
June 20, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28617968/diversity-of-human-herpesvirus-8-genotypes-in-patients-with-aids-and-non-aids-associated-kaposi-s-sarcoma-castleman-s-disease-and-primary-effusion-lymphoma-in-argentina
#11
Celeste Luján Pérez, Mónica I Tous
HHV-8 genotypes are distributed heterogeneously worldwide. The variable K1 gene and the conserved ORF26E region serve to genotype. The aim of the study was to characterize HHV-8 isolates from patients with AIDS, classical, and iatrogenic KS, primary effusion lymphoma and Castleman's disease and one organ donor from Argentina by analysis of ORFK1 and ORF26E regions. DNA was extracted from fresh or paraffin embedded biopsies, blood and saliva samples and submitted to HHV-8 PCR. Phylogenetic analyses of ORFK1 showed that subtypes C (C1, C2 and C3), B1 and A (A1, A2 and A3) were present in 70...
June 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28613048/is-the-second-to-fourth-digit-ratio-2d-4d-a-biomarker-of-sex-steroids-activity
#12
Vincenzo de Sanctis, Ashraf T Soliman, Heba Elsedfy, Nada Soliman, Rania Elalaily, Salvatore Di Maio
The second-to-fourth digit ratio (2D:4D) has been used as an indirect method to investigate the putative effects of prenatal exposure to androgens, and has been reported to be smaller in males than in females. This gender difference in digit length ratios has been linked with the in utero balance of androgens to oestrogen. This sexual dimorphism in 2D:4D ratios is apparent by 2 years of age and seems to be established early in life, possibly by the 14th week of gestation. Digits in females attain their maximum length at about 2...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28611373/is-there-any-clinical-relevant-difference-between-non-mosaic-klinefelter-syndrome-patients-with-or-without-androgen-receptor-variations
#13
Umberto Valente, Cinzia Vinanzi, Savina Dipresa, Riccardo Selice, Massimo Menegazzo, Massimo Iafrate, Carlo Foresta, Andrea Garolla
Klinefelter Syndrome (KS) is the most common chromosomal disorder in men leading to non-obstructive azoospermia. Spermatozoa can be found by TESE in about 50% of adults with KS despite severe testicular degeneration. We evaluated AR variations and polymorphism length in 135 non-mosaic KS patients, aimed to find possible correlation with clinical features, sex hormones and sperm retrieval. Among 135 KS patients we found AR variations in eight subjects (5.9%). All variations but one caused a single amino acid substitution...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28610760/iatrogenic-kaposi-s-sarcoma-a-retrospective-cohort-study-in-an-italian-tertiary-care-centre
#14
L Brambilla, A Tourlaki, G Genovese
AIMS: Kaposi's sarcoma (KS) is a lymphoangioproliferative multicentric disorder. Among its four distinct clinical variants, iatrogenic KS (iKS) typically affects patients who have received immunosuppressant regimens for organ transplants, proliferative disorders, or immune-mediated diseases. The aim of the current study was to examine the characteristics of a cohort of patients with iKS, evaluating the differences in terms of epidemiological and clinical features, management and outcomes between organ transplant recipients (OTR) and patients immunosuppressed for other medical conditions...
June 10, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28609402/hiv-associated-kaposi-sarcoma-and-related-diseases
#15
Priscila H Gonçalves, Thomas S Uldrick, Robert Yarchoan
The search for the etiologic agent for Kaposi sarcoma (KS) led to the discovery of Kaposi sarcoma associated herpesvirus (KSHV) in 1994. KSHV, also called human herpesvirus-8 (HHV-8) has since been shown to be the etiologic agent for several other tumors and diseases, including primary effusion lymphoma (PEL), an extracavitary variant of PEL, KSHV-associated diffuse large B-cell lymphoma, a form of multicentric Castleman disease (MCD), and KSHV inflammatory cytokine syndrome (KICS). KSHV encodes several genes that interfere with innate and specific immunity, thwart apoptosis, enhance cell proliferation and cytokine production, and promote angiogenesis, and these play important roles in the disease pathogenesis...
June 12, 2017: AIDS
https://www.readbyqxmd.com/read/28606034/high-seroprevalence-of-human-herpesvirus-8-infection-in-hiv-positive-homosexual-men-in-jiangsu-province-china
#16
Jiayan Li, Jinyun Song, Guolei Tan, Jianfang Wang, Zhenxian Zhou, Xuping Wu
BACKGROUD: HIV-infected homosexual men are more frequently diagnosed with Kaposi's sarcoma. With the increase of HIV-infected homosexual men in China, we urgently need to know the KS-related human herpesvirus (KSHV/HHV-8) seroprevalence in this population. To investigate the HHV-8 prevalence among HIV-positive homosexual men, we recruited 183 patients naive of antiretroviral therapy (ART) whose blood samples present HIV-antibody positive confirmed by western blot. METHODS: HIV viral load was tested using Cobas TaqMan HIV-1 test Version 2...
June 12, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28605635/expression-of-herv-k108-envelope-interferes-with-hiv-1-production
#17
Sandra N Terry, Lara Manganaro, Alvaro Cuesta-Dominguez, Daria Brinzevich, Viviana Simon, Lubbertus C F Mulder
The human endogenous retroviruses (HERV)-K of the HML-2 group include full-length or near full-length elements encoding functional proteins, and are classified as type-1 or type-2 (type-1 has a deletion in the 5' end of the env gene). Because proteins of different retroviruses can interact, we hypothesized that HERV-K envelope (Env) could influence HIV-1 replication. Here we describe the negative effect of envelope expression of certain type-2 HERV-Ks on HIV-1 production. All HIV-1 and SIV strains tested were susceptible to various degrees to inhibition by the HERV-K108 envelope...
June 9, 2017: Virology
https://www.readbyqxmd.com/read/28604864/from-the-kohn-sham-band-gap-to-the-fundamental-gap-in-solids-an-integer-electron-approach
#18
E J Baerends
It is often stated that the Kohn-Sham occupied-unoccupied gap in both molecules and solids is "wrong". We argue that this is not a correct statement. The KS theory does not allow to interpret the exact KS HOMO-LUMO gap as the fundamental gap (difference (I - A) of electron affinity (A) and ionization energy (I), twice the chemical hardness), from which it indeed differs, strongly in molecules and moderately in solids. The exact Kohn-Sham HOMO-LUMO gap in molecules is much below the fundamental gap and very close to the much smaller optical gap (first excitation energy), and LDA/GGA yield very similar gaps...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28599623/-reliability-of-the-norwegian-version-of-the-short-physical-performance-battery-in-older-people-with-and-without-dementia
#19
Cecilie Fromholt Olsen, Astrid Bergland
BACKGROUND: The purpose of the study was to establish the test-retest reliability of the Norwegian version of the Short Physical Performance Battery (SPPB). METHODS: This was a cross- sectional reliability study. A convenience sample of 61 older adults with a mean age of 88.4(8.1) was tested by two different physiotherapists at two time points. The mean time interval between tests was 2.5 days. The Intraclass Correlation Coefficient model 3.1 (ICC, 3.1) with 95% confidence intervals as well as the weighted Kappa (K) were used as measures of relative reliability...
June 9, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28595407/on-extending-kohn-sham-density-functionals-to-systems-with-fractional-number-of-electrons
#20
Chen Li, Jianfeng Lu, Weitao Yang
We analyze four ways of formulating the Kohn-Sham (KS) density functionals with a fractional number of electrons, through extending the constrained search space from the Kohn-Sham and the generalized Kohn-Sham (GKS) non-interacting v-representable density domain for integer systems to four different sets of densities for fractional systems. In particular, these density sets are (I) ensemble interacting N-representable densities, (II) ensemble non-interacting N-representable densities, (III) non-interacting densities by the Janak construction, and (IV) non-interacting densities whose composing orbitals satisfy the Aufbau occupation principle...
June 7, 2017: Journal of Chemical Physics
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