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JOURNAL ARTICLE
Margot E Manning, Zachary Fricker
BACKGROUND: Cardiopulmonary resuscitation (CPR) outcomes among patients with cirrhosis are poor, but factors associated with outcomes and provider awareness remain under-evaluated. AIMS: We retrospectively investigated in-hospital CPR mortality among patients with cirrhosis, and, using these results, undertook an educational study among providers to improve knowledge of CPR outcomes and code status in patients with cirrhosis. METHODS: We identified patients with cirrhosis admitted from 2012 to 2022 who underwent CPR at our center; the primary outcome was survival-to-discharge...
April 23, 2024: Digestive Diseases and Sciences
#2
REVIEW
Amy A Yau, Florian Buchkremer
Hyponatremia is common in patients with liver disease and is associated with increased mortality, morbidity, and a reduced quality of life. In liver transplantation, the inclusion of hyponatremia in organ allocation scores has reduced waitlist mortality. Portal hypertension and the resulting lowering of the effective arterial blood volume are important pathogenetic factors, but in most patients with liver disease, hyponatremia is multifactorial. Treatment requires a multifaceted approach that tries to reduce electrolyte-free water intake, restore urinary dilution, and increase nonelectrolyte solute excretion...
March 2024: Adv Kidney Dis Health
#3
JOURNAL ARTICLE
Zhiyong Guo, Yao Liu, Qi Ling, Leibo Xu, Tielong Wang, Jiaxing Zhu, Yimou Lin, Xinjun Lu, Wei Qu, Fan Zhang, Zhijun Zhu, Jian Zhang, Zehua Jia, Ping Zeng, Wenjing Wang, Qiang Sun, Qijie Luo, Zemin Hu, Zhouying Zheng, Yingbin Jia, Jian Li, Yujian Zheng, Mengchao Wang, Shaoping Wang, Zemin Han, Sheng Yu, Chuanjiang Li, Shuhua Zhang, Jun Xiong, Feiwen Deng, Ying Liu, Huanwei Chen, Yanfeng Wang, Ling Li, Wenjin Liang, Andrea Schlegel, Nashan Björn, Chao Liu, Shusen Zheng, Xiaoshun He
Immune checkpoint inhibitors (ICIs) as a downstaging or bridging therapy for liver transplantation (LT) in hepatocellular carcinoma (HCC) patients is rapidly increasing. However, the evidence about the feasibility and safety of pre-LT ICIs therapy is limited and controversial. To this end, a multicenter, retrospective cohort study was conducted in 11 Chinese centers. The results showed that 83 recipients received pre-LT ICIs therapy during the study period. The median post-LT follow up was 8.1 (interquartile range [IQR] 3...
April 18, 2024: American Journal of Transplantation
#4
Srestha Mitra, Jai Bhagwan, Ashish William, Oves Siddiqui, Sonal Saxena
Paeniclostridium sordellii, an anaerobic bacterium, causes hepatic infections in alcoholics and post-surgery (liver transplantation). While liver and brain abscesses are rare, drainage procedures and targeted antibiotic therapy assisted by early microbiological diagnosis have reduced mortality rates. We report a rare case of pyogenic liver abscess caused by Paeniclostridium sordellii in India, the early diagnosis of which has led to life saving outcome for the patient. Hence, the microbiological diagnosis and comprehensive medical-surgical treatment are vital for preventing mortality in Paeniclostridium sordellii infections...
April 17, 2024: Indian Journal of Medical Microbiology
#5
JOURNAL ARTICLE
Fredrik Åberg, Z Gordon Jiang, Helena Cortez-Pinto, Ville Männistö
Alcohol-associated liver disease (ALD), as highlighted in this narrative review, is a major public health concern, increasingly impacting global disease burden and premature mortality. In 2019, ALD accounted for the loss of 11 million life-years worldwide. The rising number of deaths and disability-adjusted life years attributed to ALD, particularly pronounced in America, are alarming. Projections suggest that the economic impact of ALD, as seen in the United States, could potentially double by 2040. ALD is increasingly prevalent among younger adults and has become the leading cause for liver transplantation in both America and Europe...
April 19, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#6
JOURNAL ARTICLE
Cristal Brown, Callaghan Ray, Garrett Kuketz, John Virostko
BACKGROUND: Metabolic factors have a significant role in the morbidity and mortality associated with chronic liver disease. The pancreas has a central role in metabolism and metabolic risk factors but has been largely ignored in liver transplantation. Small pancreas volume has been demonstrated in pathologic conditions such as type 1 and 2 diabetes. METHODS: This study assessed abdominal imaging before and after liver transplantation to determine if liver transplantation induces changes in pancreas volume in living donor liver transplant recipients...
April 19, 2024: Transplantation
#7
JOURNAL ARTICLE
Ancy Ninan, Ganesh Mohan, Vishal Shanbhag, Deepika Chenna, Shamee Shastry, Shwethapriya Rao
BACKGROUND: Acute liver failure (ALF) following yellow phosphorous (YP) ingestion is similar to acetaminophen-induced ALF and it has become a public concern in our region. This study assessed low volume therapeutic plasma exchange (LV-TPE) efficacy in improving the transplant free survival in YP poisoning. METHODS: Adult patients with toxicology reports of YP and ALF requiring critical care were included in the study. LV-TPE was planned for three consecutive days and three more if required...
June 2024: Journal of Clinical Apheresis
#8
JOURNAL ARTICLE
Shailesh Sable, Vibha Varma, Sorabh Kapoor, Samriddhi Poyekar, Barun Nath, Vinay Kumaran
BACKGROUND: Living donor liver transplant (LDLT) is based on the principle of double equipoise. Organ shortage in Asian countries has led to development of high-volume LDLT programs with good outcomes. Safety of live liver donor is the Achilles heel of LDLT program and every effort should be made to achieve low morbidity and near zero mortality rates. METHODS: We retrospectively analyzed our prospectively maintained donor morbidity data (outcomes) of 177 donors in a new transplant program setup in western India by an experienced surgeon...
April 17, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#9
JOURNAL ARTICLE
Vishal C Patel, Mark J McPhail, Ruhama Uddin, Hassan Jafari, Vanessa Lawrence, Clair Le Boutillier, James Shearer, Nahel Yaziji, Angela Cape, Haroon Ahmed, Christopher Ward, Peter Walsh, Kevin Besly, Ane Zamalloa, Joanna Kelly, Ben Carter
BACKGROUND: Liver disease is within the top five causes of premature death in adults. Deaths caused by complications of cirrhosis continue to rise, whilst deaths related to other non-liver disease areas are declining. Portal hypertension is the primary sequelae of cirrhosis and is associated with the development of variceal haemorrhage, ascites, hepatic encephalopathy and infection, collectively termed hepatic decompensation, which leads to hospitalisation and mortality. It remains uncertain whether administering a non-selective beta-blocker (NSBB), specifically carvedilol, at an earlier stage, i...
April 16, 2024: Trials
#10
JOURNAL ARTICLE
Johannes Hilberath, Vittoria Camelli, Christiane Hofer, Steffen Hartleif, Silvio Nadalin, Maren Peters, Matthias Kumpf, Andrea Bevot, Matthias Zirngibl, Marcus Weitz, Ekkehard Sturm
OBJECTIVES: Paediatric acute liver failure (PALF) is a life-threatening disease. Management aims to support hepatic regeneration or to bridge to liver transplantation. High-volume plasmapheresis (HVP) removes protein-bound substances, alleviates inflammation, and improves survival in adult acute liver failure. However, experience with HVP in PALF is limited. Aim of this study is to report on feasibility, safety, efficacy and outcomes of HVP in PALF. METHODS: Retrospective observational study in children with PALF...
April 16, 2024: Journal of Pediatric Gastroenterology and Nutrition
#11
JOURNAL ARTICLE
Owen Jones, Marco Paw Claasen, Tommy Ivanics, Woo Jin Choi, Felipe Gavaria, Luckshi Rajendran, Anand Ghanekar, Gideon Hirschfield, Aliya Gulamhusein, Chaya Shwaartz, Trevor Reichman, Blayne Amir Sayed, Markus Selzner, Mamatha Bhat, Cynthia Tsien, Elmar Jaeckel, Les Lilly, Ian D McGilvray, Mark S Cattral, Nazia Selzner, Gonzalo Sapisochin
Background Living donor liver transplantation (LDLT) offers the opportunity to decrease waitlist time and mortality for patients with AILD; autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). We compared the survival of patients with a potential live donor (pLDLT) on the waitlist vs. no potential live donor (pDDLT), on an intention-to-treat (ITT) basis. Methods Our retrospective cohort study investigated adults with AILD listed for liver transplant at our program between 2000 and 2021...
April 16, 2024: Liver Transplantation
#12
JOURNAL ARTICLE
Alessandro Parente, Mureo Kasahara, Vincent E De Meijer, Koji Hashimoto, Andrea Schlegel
Liver transplantation is the only lifesaving procedure for children with end-stage liver disease. The field is however heterogenic with various graft types, recipient age and weight and underlying diseases. Despite recently improved overall outcomes and the expanded use of living donors, waiting list mortality remains unacceptable particularly in small children and infants. Based on the known negative effect of elevated donor age, higher body mass index, and prolonged cold ischemia time, the number of available donors for pediatric recipients is limited...
April 16, 2024: Liver Transplantation
#13
JOURNAL ARTICLE
Christian T J Magyar, Lea Bühlmann, Chiara Becchetti, Lara Beekman, Daniel Candinas, Guido Beldi, Corina Kim-Fuchs, Annalisa Berzigotti, Vanessa Banz
BACKGROUND: Physical deconditioning affects patients suffering from end-stage liver disease (ESLD). Liver transplantation (LT) is the only curative option for ESLD. Growing evidence suggests that pre-habilitation is beneficial in reducing post-surgical morbidity and mortality. We investigated physical activity (PA) in patients awaiting LT in a country with long waiting times. METHODS: Prospective, single center, longitudinal study in Bern, Switzerland between June 2019 and February 2020 (halted due to SARS-CoV-2 pandemic), with follow-up data up to six months post-transplant...
April 3, 2024: Hepatobiliary Surgery and Nutrition
#14
JOURNAL ARTICLE
Kristin J Dolan, Ayse Arikan, Anna M Banc-Husu, Muhammad Umair Mukhtar Mian, Sameer Thadani, Jeffrey Quinn Lee, Lacey Stribling, N Thao N Galván, John Goss, Rahul Baijal, Moreshwar S Desai
BACKGROUND: Intraoperative Continuous Renal Replacement Therapy (iCRRT) can prevent life-threatening complications, facilitate fluid management, and maintain metabolic homeostasis during liver transplantation (LT) in adults. There is a paucity of data in pediatric LT. We evaluated the safety, efficacy, and impact on survival of iCRRT in pediatric LT. METHODS: We conducted a retrospective cohort study of all children requiring CRRT pre-OLT at a quaternary children's hospital from 2014 to 2022...
April 2024: Clinical Transplantation
#15
JOURNAL ARTICLE
Yutaka Endo, Diamantis I Tsilimigras, Mujtaba Khalil, Jason Yang, Selamawit Woldesenbet, Kazunari Sasaki, Ashley Limkemann, Austin Schenk, Timothy M Pawlik
BACKGROUND: The impact of county-level food access on mortality associated with steatotic liver disease, as well as post-liver transplant outcomes among individuals with steatotic liver disease, have not been characterized. METHODS: Data on steatotic liver disease-related mortality and outcomes of liver transplant recipients with steatotic liver disease between 2010 and 2020 were obtained from the Centers for Disease Control Prevention mortality as well as the Scientific Registry of Transplant Recipients databases...
April 11, 2024: Surgery
#16
JOURNAL ARTICLE
Roos A Groen, Fei Lynn Barbero, Susan E Fischer, Paul R M van Dijkman, Jeroen J Bax, Maarten E Tushuizen, J Wouter Jukema, Minneke J Coenraad, Michiel A de Graaf
BACKGROUND: Guidelines recommend standard pre-operative cardiac screening in all liver transplantation (LT) recipients, despite the relatively low prevalence of obstructive coronary artery disease. Most LT recipients often have non-gated computed tomography (CT) performed of the chest and abdomen. This study evaluated the ability of coronary artery calcification (CAC) assessment on consecutively available scans, to identify a selection of low-risk patients, in whom further cardiac imaging can be safely withheld...
April 10, 2024: International Journal of Cardiology
#17
REVIEW
Abdulellah Almohaya, Jordana Fersovich, R Benson Weyant, Oscar A Fernández García, Sandra M Campbell, Karen Doucette, Tamara Lotfi, Juan G Abraldes, Carlos Cervera, Dima Kabbani
BACKGROUND: The Global increase in colonization by multidrug-resistant (MDR) bacteria poses a significant concern. The precise impact of MDR colonization in solid organ transplant recipients (SOTR) remains not well established. OBJECTIVES: Assess the impact of MDR colonization on SOTR's mortality, infection, or graft-loss. DATA SOURCE: Data from PROSPERO, OVID Medline, Ovid EMBASE, Wiley Cochrane Library, ProQuest Dissertations, Theses Global, and SCOPUS, were systematically reviewed spanning from inception until March 20, 2023...
April 10, 2024: Clinical Microbiology and Infection
#18
JOURNAL ARTICLE
Yixiao Pan, Zhigang Zheng, Xueliang Zhang, Shupeng Liu, Shiya Zhuansun, Shiming Gong, Shilun Li, Hongye Wang, Yiwen Chen, Taihua Yang, Huimin Wu, Feng Xue, Qiang Xia, Kang He
Partial hepatectomy is an essential surgical technique used to treat advanced liver diseases such as liver tumors, as well as for performing liver transplants from living donors.However, postoperative complications such as bleeding, abdominal adhesions, wound infections, and accelerated liver regeneration pose significant challenges and increase morbidity and mortality rates.We have developed a self-repairing mixed hydrogel (O5H2/Cu2+/SCCK) containing bioactive cell factors (SCCK) derived from Human Umbilical Cord Mesenchymal Stem Cells (HUMSCs) treated with the traditional Chinese remedy Tanshinone IIA (TSA)...
April 12, 2024: Advanced Healthcare Materials
#19
JOURNAL ARTICLE
Winston Dunn, Yanming Li, Ashwani K Singal, Douglas A Simonetto, Luis A Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, María Ayala-Valverde, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes-López, Carolina Ramirez-Cadiz, Dalia Morales-Arraez, Wei Zhang, Steve Qian, Joseph C Ahn, Seth Buryska, Heer Mehta, Nicholas Dunn, Muhammad Waleed, Horia Stefanescu, Andreea Bumbu, Adelina Horhat, Bashar Attar, Rohit Agrawal, Joaquín Cabezas, Victor Echavaría, Berta Cuyàs, Maria Poca, German Soriano, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, Fátima Higuera-de-la-Tijera, Anand V Kulkarni, P Nagaraja Rao, Patricia Guerra-Salazar, Lubomir Skladaný, Natália Kubánek, Veronica Prado, Ana Clemente-Sanchez, Diego Rincon, Tehseen Haider, Kristina R Chacko, Gustavo A Romero, Florencia D Pollarsky, Juan C Restrepo, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria L Garrido, Sebastián Marciano, Melisa Dirchwolf, Victor Vargas, César Jiménez, David Hudson, Guadalupe García-Tsao, Guillermo Ortiz, Juan G Abraldes, Patrick S Kamath, Marco Arrese, Vijay H Shah, Ramon Bataller, Juan P Arab
BACKGROUND AIMS: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day mortality. Utilizing artificial intelligence (AI) in a global cohort, we sought to derive and validate an enhanced prognostic model. APPROACH AND RESULTS: The Global AlcHep initiative, a retrospective study across 23 centers in 12 countries, enrolled AH patients per NIAAA criteria. Centers were partitioned into derivation (11 centers, 860 patients) and validation cohorts (12 centers, 859 patients)...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#20
REVIEW
Ze Xiang, Jiarui Li, Huixuan Zeng, Xiaonan Xiang, Fengqiang Gao, Kai Wang, Xuyong Wei, Shusen Zheng, Xiao Xu
End-stage liver disease (ESLD), stemming from a spectrum of chronic liver pathologies including chronic liver failure, acute cirrhosis decompensation and hepatocellular carcinoma, imposes a significant global healthcare burden. Liver transplantation (LT) remains the only treatment for ESLD. However, the escalating mortality on transplant waitlists has prompted the utilization of marginal liver grafts in LT procedures. These grafts primarily encompass elderly livers, steatotic livers, livers from donation after circulatory death, split livers and those infected with the hepatitis virus...
April 7, 2024: Aging and Disease
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