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https://www.readbyqxmd.com/read/29237970/a-dosimetric-comparison-between-three-dimensional-conformal-radiation-therapy-and-intensity-modulated-radiation-therapy-in-the-treatment-of-posterior-fossa-boost-in-medulloblastoma
#1
Meenu Gupta, Ravi Kant, Vipul Nautiyal, Jyoti Bisht, Shalindra Raghuvanshi, Manju Saini, B P Kalra, Mushtaq Ahmad
AIMS: To compare three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) in posterior fossa (PF) boost in children with medulloblastoma (MB); dosimetrically evaluating and comparing both techniques with regard to target coverage and doses to organs at risk. SETTINGS AND DESIGN: Structured. SUBJECTS AND METHODS: Seven previously irradiated patients of MB were retrieved and re-planned with both 3DCRT and IMRT techniques...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29235569/s-1-chemotherapy-and-intensity-modulated-radiotherapy-after-d1-d2-lymph-node-dissection-in-patients-with-node-positive-gastric-cancer-a-phase-i-ii-study
#2
X Wang, D B Zhao, L Yang, Y Chi, Y Tang, N Li, S L Wang, Y W Song, Y P Liu, W Y Liu, H Ren, T Zhang, J Y Wang, X S Chen, H Fang, W H Wang, Y X Li, J Jin
BACKGROUND: This phase I/II clinical trial investigated S-1 administered with intensity-modulated radiotherapy (IMRT) as adjuvant therapy for node-positive gastric cancer. Patients had undergone radical resection and D1/D2 lymph node dissection. METHODS: In phase I, patients received adjuvant chemoradiotherapy of IMRT (45 Gy in 25 fractions) with concurrent S-1 administered on a dose-escalation schedule to determine the recommended dose (RD). In phase II, the safety and efficacy of the RD of S-1 combined with IMRT were assessed...
December 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29235518/the-efficacy-of-intensity-modulated-radiation-therapy-in-treating-thyroid-associated-ophthalmopathy-and-predictive-factors-for-treatment-response
#3
Yong-Jiang Li, Yong Luo, Xiao-Qi Xie, Wei-Min He, Cheng Yi, Ping Li, Feng Wang
The study evaluated clinical efficacy of intensity modulated radiation therapy (IMRT) in treating patients with thyroid-associated ophthalmopathy (TAO) and defined predictive factors that associated with treatment response. A total of 178 TAO patients were treated with retro-orbital IMRT with radiation dose of 20 Gy in 10 fractions. The immediate and long-term treatment response and complications were evaluated. Besides, logistic-regression analysis was conducted to identify possible predictive factors. TAO symptom score significantly fell from the initiation to 6-month post-treatment (P < 0...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228572/gemcitabine-cisplatin-induction-chemotherapy-before-concurrent-chemotherapy-and-intensity-modulated-radiotherapy-improves-outcomes-for-locoregionally-advanced-nasopharyngeal-carcinoma
#4
Wang Fangzheng, Sun Quanquan, Jiang Chuner, Wang Lei, Yan Fengqin, Ye Zhimin, Liu Tongxin, Xu Min, Wu Peng, Jiang Haitao, Rihito Aizawa, Masoto Sakamoto, Wang Yuezhen, Fu Zhenfu
Addition of induction chemotherapy (IC) to concurrent chemoradiotherapy (CC) is an encouraging first-line treatment strategy for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We evaluated the clinical efficacy and toxicity of addition of gemcitabine plus cisplatin (GP) IC to intensity-modulated radiotherapy (IMRT) and CC for patients with locoregionally advanced NPC. At a median follow-up duration of 48 months (10-59 months), 4-year local relapse-free survival (LRFS) was 86.9%, regional relapse-free survival (RRFS) was 90...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29224820/risk-of-contralateral-nodal-failure-following-ipsilateral-imrt-for-node-positive-tonsillar-cancer
#5
Sujana Gottumukkala, Nhat-Long Pham, Baran Sumer, Larry Myers, John Truelson, Lucien Nedzi, Saad Khan, Randy Hughes, David J Sher
PURPOSE: To determine the risk of contralateral nodal failure following ipsilateral radiotherapy in a series of patients with node-positive tonsillar squamous cell carcinoma. METHODS: Retrospective review was used to identify 34 patients with well-lateralized node-positive tonsillar squamous cell carcinoma treated with definitive or adjuvant radiation to the primary site and ipsilateral neck between 2005 and 2015. Contralateral nodal failure, locoregional recurrence, distant metastasis, and overall survival were calculated using actuarial and/or cumulative incidence statistics...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224808/delayed-clinical-complete-response-to-intensity-modulated-radiotherapy-in-nasopharyngeal-carcinoma
#6
Wen-Fei Li, Yuan Zhang, Xu Liu, Ling-Long Tang, Li Tian, Rui Guo, Li-Zhi Liu, Ying Sun, Jun Ma
OBJECTIVE: Twelve weeks after radiotherapy is the recommended time-point for assessing tumor response in nasopharyngeal carcinoma (NPC); however, regression after 12 weeks remains unclear. We explored NPC regression and the prognosis of patients with delayed clinical complete response (cCR). MATERIALS AND METHODS: MRI images of 556 NPC patients treated with intensity-modulated radiotherapy (IMRT) between 2009 and 2012 were retrospectively reviewed. Clinical tumor response was assessed at 3-4 (assessment 1) and 6-9 months (assessment 2) after IMRT, and survival rates were compared...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224805/prognostic-value-of-masticatory-muscle-involvement-in-nasopharyngeal-carcinoma-patients-treated-with-intensity-modulated-radiation-therapy
#7
Min Kang, Pingting Zhou, Xueyin Liao, Meng Xu, Rensheng Wang
BACKGROUND AND PURPOSE: In 2017, the 8th edition of the nasopharyngeal carcinoma (NPC) staging manual published by the Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) defined new rules regarding the involvement of anatomical masticatory muscles (MM). The purpose of this study is to evaluate the validity of the current T-staging system after the addition of revisions regarding MM involvement. METHODS: We performed a retrospective review of 608 patients, who were newly diagnosed with NPC and treated with intensity-modulated radiotherapy (IMRT) between January 2008 and March 2010...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29223302/modeling-the-target-dose-fall-off-in-imrt-and-vmat-planning-techniques-for-cervical-sbrt
#8
A Brito Delgado, D Cohen, T Y Eng, D N Stanley, Z Shi, M Charlton, A N Gutiérrez
There has been growing interest in the use of stereotactic body radiotherapy (SBRT) technique for the treatment of cervical cancer. The purpose of this study was to characterize dose distributions as well as model the target dose fall-off for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) delivery techniques using 6 and 10 MV photon beam energies. Fifteen (n = 15) patients with non-bulky cervical tumors were planned in Pinnacle3 with a Varian Novalis Tx (HD120 MLC) using 6 and 10 MV photons with the following techniques: (1) IMRT with 10 non-coplanar beams (2) dual, coplanar 358° VMAT arcs (4° spacing), and (3) triple, non-coplanar VMAT arcs...
December 6, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29216884/intensity-modulated-radiation-therapy-and-surgery-for-management-of-retroperitoneal-sarcomas-a-single-institution-experience
#9
Pippa F Cosper, Jeffrey Olsen, Todd DeWees, Brian A Van Tine, William Hawkins, Jeff Michalski, Imran Zoberi
BACKGROUND: Peri-operative radiation of retroperitoneal sarcomas (RPS) is an important component of multidisciplinary treatment. All retrospective series thus far included patients treated with older radiation therapy (RT) techniques including 2D and 3DRT. Intensity modulated radiation therapy (IMRT) allows for selective dose escalation while sparing adjacent organs. We therefore report the first series of patients with RPS treated solely with IMRT, surgery and chemotherapy. We hypothesized that IMRT would permit safe dose escalation and superior rates of local control (LC) in this high-risk patient population...
December 8, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29215933/a-randomized-phase-ii-trial-of-induction-chemotherapy-followed-by-cisplatin-chronotherapy-versus-constant-rate-delivery-combined-with-radiotherapy
#10
P X Zhang, F Jin, Z L Li, W L Wu, Y Y Li, J H Long, G Y Chen, X X Chen, J Y Gan, X Y Gong, Q Y He, T Bi
Chronotherapy is no longer a novel concept in cancer treatment after approximately 20 years of development. Many clinical trials have provided strong supporting evidence that chronomodulated treatment yields better results than a traditional dosage regimen. This study aimed to evaluate the adverse reactions, effect on immune functions, and therapeutic efficacy of chronomodulated infusion versus flat intermittent infusion of cisplatin (DDP) combined with intensity-modulated radiation therapy (IMRT) in patients with locoregionally advanced nasopharyngeal carcinoma (NPC)...
December 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29214980/ion-chambers-compliance-results-of-brazilian-radiation-therapy-facilities
#11
Georgia Santos Joana, Camila Salata, Paulo Leal, Renato Oliveira, Nozimar do Couto, Flavia Cristina Teixeira, Abner Duarte Soares, Eduardo Sergio Santini, Marcello Gomes Gonçalves
Brazilian Nuclear Energy Commission (cnen) has been making a constant effort to keep updated with international standards and national needs to strengthen the status of radiological protection of the country. The guidelines related to radiation therapy facilities have been revised in the last five years in order to take in consideration the most relevant aspects of the growing technology as well as to mitigate the accidents or incidents observed in practice. Hence, clinical dosimeters have gained special importance in this matter...
December 7, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29213359/influence-of-radiation-treatment-technique-on-outcome-and-toxicity-in-anal-cancer
#12
Elisha T Fredman, May Abdel-Wahab, Aryavarta M S Kumar
Objective: Intensity-modulated radiation therapy (IMRT) has largely supplanted three-dimensional conformal radiation (3D-CRT) for definitive anal cancer treatment due to decreased toxicity and potentially improved outcomes. Convincing data demonstrating its advantages, however, remain limited. We compared outcomes and toxicity with concurrent chemotherapy and IMRT vs 3D-CRT for anal cancer. Methods: We performed a single-institution retrospective review of patients treated with IMRT or 3D-CRT as part of definitive mitomycin-C/5-fluorouricil-based chemoradiation for anal cancer from January 2003 to December 2012...
2017: Journal of Radiation Oncology
https://www.readbyqxmd.com/read/29212734/predictors-of-response-and-survival-in-locally-advanced-adenocarcinoma-of-the-pancreas-following-neoadjuvant-gtx-with-or-without-radiation-therapy
#13
William H Sherman, Elizabeth Hecht, David Leung, Kyung Chu
LESSONS LEARNED: There is no presenting parameter that predicts the success of neoadjuvant therapy for pancreatic cancer.Despite the images on scans following neoadjuvant therapy, all patients should be evaluated, because inflammation following radiation therapy (RT) may overstate the extent of tumor and vascular involvement. BACKGROUND: In patients presenting with locally advanced pancreatic adenocarcinoma deemed unresectable by two pancreatic cancer surgeons, we analyzed presenting tumor size, extent of vascular involvement, tumor markers, response to neoadjuvant gemcitabine (G), docetaxel (T), and capecitabine (X) with or without additional chemoradiotherapy with GX on R0 resection rates (≥2 mm margins), and survival...
December 6, 2017: Oncologist
https://www.readbyqxmd.com/read/29212220/a-new-staging-system-for-nasopharyngeal-carcinoma-based-on-intensity-modulated-radiation-therapy-imrt
#14
Min Kang, Pingting Zhou, Jianxiong Long, Guisheng Li, Haolin Yan, Guosheng Feng, Meilian Liu, Jinxian Zhu, Rensheng Wang
Objective: This study is to establish a new staging system for nasopharyngeal carcinoma (NPC) based on the magnetic resonance imaging (MRI) and intensity-modulated radiation therapy (IMRT). Methods: Totally 492 patients with nasopharyngeal carcinoma were included in this study. These patients were diagnosed by pathological detection (without distant metastasis) and underwent the initial treatment of IMRT. These patients were subjected to the staging with the International Union against Cancer/American Joint Committee on Cancer (UICC/AJCC) staging system...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207865/prognostic-value-of-nodal-suvmax-of-18f-fdg-pet-ct-in-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#15
So Jung Lee, Chul-Seoung Kay, Yeon-Sil Kim, Seok Hyun Son, Myungsoo Kim, Sea-Won Lee, Hye Jin Kang
Purpose: To investigate the predictive role of maximum standardized uptake value (SUVmax) of 2-[18F]fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in nasopharyngeal cancer patients treated with intensitymodulated radiotherapy (IMRT). Materials and Methods: Between October 2006 and April 2016, 53 patients were treated with IMRT in two institutions and their PET/CT at the time of diagnosis was reviewed. The SUVmax of their nasopharyngeal lesions and metastatic lymph nodes (LN) was recorded...
December 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29207864/long-term-cosmesis-following-a-novel-schedule-of-accelerated-partial-breast-radiation-in-selected-early-stage-breast-cancer-result-of-a-prospective-clinical-trial
#16
Mutlay Sayan, Daphne Hard, Karen Wilson, Carl Nelson, Havaleh Gagne, Deborah Rubin, Ruth Heimann
Purpose: There is controversy regarding the cosmetic outcome after accelerated partial breast radiation (APBR). We report the cosmetic outcome from a single-arm prospective clinical trial of APBR delivered using intensity-modulated radiation therapy (IMRT) in elderly patients with stage I breast cancer (BC), using a novel fractionation schedule. Materials and Methods: Forty-two patients aged ≥65, with Stage I BC who underwent breast-conserving surgery were enrolled in a phase I/II study evaluating a 2-week course of APBR...
December 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29207634/treatment-plan-comparison-between-tri-co-60-magnetic-resonance-image-guided-radiation-therapy-and-volumetric-modulated-arc-therapy-for-prostate-cancer
#17
Jong Min Park, So-Yeon Park, Chang Heon Choi, Minsoo Chun, Jin Ho Kim, Jung-In Kim
To investigate the plan quality of tri-Co-60 intensity-modulated radiation therapy (IMRT) with magnetic-resonance image-guided radiation therapy compared with volumetric-modulated arc therapy (VMAT) for prostate cancer. Twenty patients with intermediate-risk prostate cancer, who received radical VMAT were selected. Additional tri-Co-60 IMRT plans were generated for each patient. Both primary and boost plans were generated with tri-Co-60 IMRT and VMAT techniques. The prescription doses of the primary and boost plans were 50...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29204529/late-small-bowel-toxicity-after-aggressive-abdominopelvic-intensity-modulated-radiation-therapy
#18
Andrew Ling, Eli Furhang, Shannon N Ryemon, Ronald D Ennis
Purpose: We retrospectively analyzed late small bowel toxicity in patients who received abdominal or pelvic intensity modulated radiation therapy (IMRT) to the small bowel with a maximum dose greater than the generally accepted maximal tolerable dose of 45 Gy. Methods and materials: All patients (N = 94) who received IMRT with a point dose of at least 45 Gy to tightly contoured small bowel between 2005 and 2014 at our institution were included. The median prescribed treatment dose was 70...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204527/outcomes-and-toxicity-of-313-prostate-cancer-patients-receiving-helical-tomotherapy-after-radical-prostatectomy
#19
Lindsay Jensen, Bertram Yuh, Jeffrey Y C Wong, Timothy Schultheiss, Jonathan Cheng, Nora Ruel, Przemyslaw Twardowski, Sagus Sampath
Purpose: There are limited long-term data on patients treated with image guided intensity modulated radiation therapy (IG-IMRT) for prostate cancer recurrence or high-risk disease features after radical prostatectomy. We report single-institution results for patients treated with IG-IMRT and identify variables associated with outcome. Methods and materials: This is a retrospective chart review consisting of 313 consecutive patients who were treated with adjuvant or salvage IG-IMRT from 2004 to 2013...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29203289/time-and-dose-related-changes-in-lung-perfusion-after-definitive-radiotherapy-for-nsclc
#20
Katherina P Farr, Azza A Khalil, Ditte S Møller, Henrik Bluhme, Stine Kramer, Anni Morsing, Cai Grau
BACKGROUND AND PURPOSE: To examine radiation-induced changes in regional lung perfusion per dose level in 58 non-small-cell lung cancer (NSCLC) patients treated with intensity-modulated radiotherapy (IMRT). MATERIAL AND METHODS: NSCLC patients receiving chemo-radiotherapy (RT) of minimum 60 Gy were included prospectively in the study. Lung perfusion single-photon emission computed tomography (SPECT/CT) was performed before and serially after RT. Changes (relative to baseline, %) in regional lung perfusion were correlated with regional dose...
December 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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