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https://www.readbyqxmd.com/read/28819412/ct-guided-125-i-brachytherapy-for-locally-recurrent-nasopharyngeal-carcinoma
#1
Huzheng Yan, Zhiqiang Mo, Zhanwang Xiang, Dailin Rong, Yanlin Zhang, Guanyu Chen, Zhihui Zhong, Fujun Zhang, Fei Gao
Purpose: The study evaluated the feasibility, clinical effectiveness, and quality of life of computed tomography (CT)-guided (125)I brachytherapy for locally recurrent nasopharyngeal carcinoma (NPC). Methods: We recruited 81 patients diagnosed with locally recurrent NPC after previous radiotherapy with or without chemotherapy. Thirty-nine patients received (125)I brachytherapy (group A) and 42 received re-irradiation (IMRT, group B). The evaluated outcomes were local control, complications, and quality of life...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28815994/imrt-qa-using-machine-learning-a-multi-institutional-validation
#2
Gilmer Valdes, Maria F Chan, Seng Boh Lim, Ryan Scheuermann, Joseph O Deasy, Timothy D Solberg
PURPOSE: To validate a machine learning approach to Virtual intensity-modulated radiation therapy (IMRT) quality assurance (QA) for accurately predicting gamma passing rates using different measurement approaches at different institutions. METHODS: A Virtual IMRT QA framework was previously developed using a machine learning algorithm based on 498 IMRT plans, in which QA measurements were performed using diode-array detectors and a 3%local/3 mm with 10% threshold at Institution 1...
August 17, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28814884/outcomes-of-adding-induction-chemotherapy-to-concurrent-chemoradiotherapy-for-stage-t3n0-1-nasopharyngeal-carcinoma-a-propensity-matched-study
#3
Xiao-Wen Lan, Yao Xiao, Xue-Bin Zou, Xiao-Min Zhang, Pu-Yun OuYang, Fang-Yun Xie
OBJECTIVE: Our objective was to examine whether adding induction chemotherapy to concurrent chemoradiotherapy improved survival in stage III nasopharyngeal carcinoma (NPC) patients, especially in low-risk patients at stage T3N0-1. MATERIALS AND METHODS: We retrospectively analyzed 687 patients with stage T3N0-1 NPC treated with intensity-modulated radiation therapy (IMRT) plus concurrent chemotherapy (CC) with or without induction chemotherapy (IC). Propensity score matching (PSM) method was used to select 237 pairs of patients from two cohorts...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28810885/intensity-modulated-versus-3-dimensional-conformal-radiotherapy-in-the-definitive-treatment-of-esophageal-cancer-comparison-of-outcomes-and-acute-toxicity
#4
Matthias Felix Haefner, Kristin Lang, Vivek Verma, Stefan Alexander Koerber, Lorenz Uhlmann, Juergen Debus, Florian Sterzing
BACKGROUND: Though the vast majority of seminal trials for locally advanced esophageal cancer (EC) utilized three-dimensional conformal radiotherapy (3DCRT), the advanced and highly conformal technology known as intensity-modulated radiotherapy (IMRT) can decrease doses to critical cardiopulmonary organs. To date, there have been no studies comparing both modalities as part of definitive chemoradiation (dCRT) for EC. Herein, we investigated local control and survival and evaluated clinical factors associated with these endpoints between cohorts...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28806994/patterns-of-locoregional-failure-following-post-operative-intensity-modulated-radiotherapy-to-oral-cavity-cancer-quantitative-spatial-and-dosimetric-analysis-using-a-deformable-image-registration-workflow
#5
Abdallah S R Mohamed, Andrew J Wong, Clifton D Fuller, Mona Kamal, Gary B Gunn, Jack Phan, William H Morrison, Beth M Beadle, Heath Skinner, Stephen Y Lai, Sean R Quinlan-Davidson, Abdelaziz M Belal, Ahmed G El-Gowily, Steven J Frank, David I Rosenthal, Adam S Garden
BACKGROUND: We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer patients receiving post-operative IMRT (PO-IMRT). METHODS: Two hundred eighty-nine OCC patients receiving PO-IMRT were retrospectively reviewed from 2000 to 2012. Diagnostic CT documenting recurrence (rCT) was co-registered with planning CT (pCT) using a validated deformable image registration software. Manually segmented recurrent gross disease (rGTV) was deformed to co-registered pCTs...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28806990/dvh-and-ntcp-based-dosimetric-comparison-of-different-longitudinal-margins-for-vmat-imrt-of-esophageal-cancer
#6
S Münch, M Oechsner, S E Combs, D Habermehl
PURPOSE: To cover the microscopic tumor spread in squamous cell carcinoma of the esophagus (SCC), longitudinal margins of 3-4 cm are used for radiotherapy (RT) protocols. However, smaller margins of 2-3 cm might be reasonable when advanced diagnostic imaging is integrated into target volume delineation. Purpose of this study was to compare the dose distribution and deposition to the organs at risk (OAR) for different longitudinal margins using a DVH- and NTCP-based approach. METHODS: Ten patients with SCC of the middle or lower third were retrospectively selected...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28805047/outcomes-of-post-prostatectomy-radiotherapy-at-a-regional-cancer-centre
#7
Luke Nicholls, Amber Winter, Ashley Harwood, Ashley Plank, Preeti Bagga, Winnie Wong, Eric Khoo
INTRODUCTION: To investigate the efficacy and toxicity of radiation therapy (RT) after radical prostatectomy (RP) for prostate cancer at Radiation Oncology Centres, Toowoomba. METHODS: The electronic medical records of 130 consecutive patients with histologically proven prostate adenocarcinoma who underwent post-prostatectomy RT between January 2008 and December 2014 were analysed. Primary endpoint was Biochemical Recurrence (BCR) after RT. BCR was defined by PSA > 0...
August 14, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28800298/impact-of-field-number-and-beam-angle-on-functional-image-guided-lung-cancer-radiotherapy-planning
#8
Bilal A Tahir, Chris M Bragg, Jim M Wild, James A Swinscoe, Sarah E Lawless, Kerry A Hart, Matthew Q Hatton, Rob H Ireland
To investigate the effect of beam angles and field number on functionally-guided intensity modulated radiotherapy (IMRT) normal lung avoidance treatment plans that incorporate hyperpolarised helium-3 magnetic resonance imaging ((3)He MRI) ventilation data. Eight non-small cell lung cancer patients had pre-treatment (3)He MRI that was registered to inspiration breath-hold radiotherapy planning computed tomography. IMRT plans that minimised the volume of total lung receiving  ⩾20 Gy (V20) were compared with plans that minimised (3)He MRI defined functional lung receiving  ⩾20 Gy (fV20)...
August 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28799273/sensitivity-of-array-detector-measurements-in-determining-shifts-of-mlc-leaf-positions
#9
Qingyang Shang, Andrew Godley, Long Huang, Peng Qi, Ping Xia
Using a MatriXX 2D ionization chamber array, we evaluated the detection sensitivity of systematically introduced MLC leaf positioning shifts to test whether the conventional IMRT QA method can be used for quality assurance of an MLC tracking algorithm. Because of finite special resolution, we first tested whether the detection sensitivity was dependent of the locations of leaf shifts and positions of ionization chambers. We then introduced the same systematic leaf shifts in two clinical intensity modulated radiotherapy plans (prostate and head and neck cancer)...
August 11, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28797999/long-term-results-of-post-operative-pelvic-image-guided-intensity-modulated-radiotherapy-in-gynecological-malignancies
#10
Rashi Agrawal, Sowmiya Prithiviraj, Dinesh Singh, Vaishali Zamre, Sandeep Agrawal, Arun Kumar Goel, Kanika Gupta, Bala Subramanian
OBJECTIVE: To assess late clinical outcomes with image guided intensity modulated radiotherapy (IG- IMRT) in gynecological malignancies. PATIENTS AND METHODS: We have been practicing IG IMRT for gynecological malignancies since January 2009. Here we are presenting our experience with this modern technique at median follow up of 38 months. During whole treatment bladder filling protocol was followed. Both target volumes and critical structures were contoured according to RTOG guidelines...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28797467/outcomes-of-oral-cavity-cancer-patients-treated-with-surgery-followed-by-postoperative-intensity-modulated-radiation-therapy
#11
Sean R Quinlan-Davidson, Abdallah S R Mohamed, Jeffrey N Myers, Gary B Gunn, Faye M Johnson, Heath Skinner, Beth M Beadle, Ann M Gillenwater, Jack Phan, Steven J Frank, William N William, Andrew J Wong, Stephen Y Lai, Clifton D Fuller, William H Morrison, David I Rosenthal, Adam S Garden
OBJECTIVES: Although treatment paradigms have not changed significantly, radiotherapy, surgery, and imaging techniques have improved, leading us to investigate oncologic and survival outcomes for oral cavity squamous cell cancer (OCSCC) patients treated with surgery followed by postoperative IMRT. MATERIAL AND METHODS: Records of patients with pathological diagnosis of OCSCC treated between 2000 and 2012 were retrospectively reviewed. Patients' demographic, disease, and treatment criteria were extracted...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797459/impact-of-dose-volume-parameters-and-clinical-factors-on-acute-radiation-oral-mucositis-for-locally-advanced-nasopharyngeal-carcinoma-patients-treated-with-concurrent-intensity-modulated-radiation-therapy-and-chemoradiotherapy
#12
Kaixin Li, Ling Yang, Peiling Xin, Yuanyuan Chen, Qiang-Ying Hu, Xiao-Zhong Chen, Ming Chen
PURPOSE: To prospectively identify the predictive value of different dosimetric parameters and also assess the predictors of acute radiation oral mucositis (ROM). METHODS: In accordance with the RTOG scoring criteria, ninety-two patients with locally advanced nasopharyngeal carcinoma (NPC) treated with concurrent chemoradiotherapy were evaluated for acute ROM which was defined as severe when the score ≥3. Patients' medical records and dosimetric data exported from IMRT plan enable the authors to perform a statistical analysis for the parameters as potential predictors of severe ROM...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28795303/the-feasibility-of-prostate-specific-membrane-antigen-positron-emission-tomography-psma-pet-ct-guided-radiotherapy-in-oligometastatic-prostate-cancer-patients
#13
O C Guler, B Engels, C Onal, H Everaert, R Van den Begin, T Gevaert, M de Ridder
BACKGROUND: To investigate the efficacy and toxicity of 68Ga-PSMA-HBED-CC ((68)Ga-PSMA) PET-CT-guided RT in the treatment of oligometastatic prostate cancer retrospectively. METHODS: A total of 23 prostate cancer patients with biochemical relapse, of which 13 were castration sensitive (CS) and 10 castration resistant (CR), were treated with intensity-modulated and image-guided RT (IMRT-IGRT) on ≤3 metastases detected by (68)Ga PSMA PET-CT. Androgen deprivation therapy was continued in CR patients...
August 9, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28781797/effect-of-modern-high-quality-prostate-intensity-modulated-radiation-therapy-on-outcome-evidence-from-a-community-radiation-oncology-program
#14
Johnny Kao, Amanda Zucker, Jonathan Timmins, Shankar Taramangalam, Jeffrey Pettit, Aaron J Woodall, Edward Loizides, Andrew T Wong
Radiation technique for prostate cancer has continuously evolved over the past several decades. The aim of the present study was to describe the effects of implementing modern prostate intensity-modulated radiation therapy (M-IMRT) on dosimetry and outcome. Between January 2010 and April 2012, 48 consecutive patients were treated with conventional prostate IMRT (C-IMRT) to a dose of 81 Gy. Between May 2012 and April 2015, 50 consecutive patients were treated with M-IMRT to the entire prostate to a dose of 75...
August 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28774596/patterns-of-failure-guided-biological-target-volume-definition-for-head-and-neck-cancer-patients-fdg-pet-and-dosimetric-analysis-of-dose-escalation-candidate-subregions
#15
Abdallah S R Mohamed, Carlos E Cardenas, Adam S Garden, Musaddiq J Awan, Crosby D Rock, Sarah A Westergaard, G Brandon Gunn, Abdelaziz M Belal, Ahmed G El-Gowily, Stephen Y Lai, David I Rosenthal, Clifton D Fuller, Michalis Aristophanous
BACKGROUND: To identify the radio-resistant subvolumes in pretreatment FDG-PET by mapping the spatial location of the origin of tumor recurrence after IMRT for head-and-neck squamous cell cancer to the pretreatment FDG-PET/CT. METHODS: Patients with local/regional recurrence after IMRT with available FDG-PET/CT and post-failure CT were included. For each patient, both pre-therapy PET/CT and recurrence CT were co-registered with the planning CT (pCT). A 4-mm radius was added to the centroid of mapped recurrence growth target volumes (rGTV's) to create recurrence nidus-volumes (NVs)...
July 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28771941/dosimetric-and-radiobiological-comparison-for-quality-assurance-of-imrt-and-vmat-plans
#16
Nava Raj Paudel, Ganesh Narayanasamy, Eun Young Han, Jose Penagaricano, Panayiotis Mavroidis, Xin Zhang, Anil Pyakuryal, Dongwook Kim, Xiaoying Liang, Steven Morrill
INTRODUCTION: The gamma analysis used for quality assurance of a complex radiotherapy plan examines the dosimetric equivalence between planned and measured dose distributions within some tolerance. This study explores whether the dosimetric difference is correlated with any radiobiological difference between delivered and planned dose. METHODS: VMAT or IMRT plans optimized for 14 cancer patients were calculated and delivered to a QA device. Measured dose was compared against planned dose using 2-D gamma analysis...
August 3, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28770294/automated-imrt-planning-in-pinnacle-a%C3%A2-study-in-head-and-neck-cancer
#17
J M A M Kusters, K Bzdusek, P Kumar, P G M van Kollenburg, M C Kunze-Busch, M Wendling, T Dijkema, J H A M Kaanders
PURPOSE: This study evaluates the performance and planning efficacy of the Auto-Planning (AP) module in the clinical version of Pinnacle 9.10 (Philips Radiation Oncology Systems, Fitchburg, WI, USA). METHODS AND MATERIALS: Twenty automated intensity-modulated radiotherapy (IMRT) plans were compared with the original manually planned clinical IMRT plans from patients with oropharyngeal cancer. RESULTS: Auto-Planning with IMRT offers similar coverage of the planning target volume as the original manually planned clinical plans, as well as better sparing of the contralateral parotid gland, contralateral submandibular gland, larynx, mandible, and brainstem...
August 2, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28767597/comparison-of-imrt-versus-3d-crt-in-the-treatment-of-esophagus-cancer-a-systematic-review-and-meta-analysis
#18
Dandan Xu, Guowen Li, Hongfei Li, Fei Jia
BACKGROUND: Esophageal cancer (EC) is a common cancer with high mortality because of its rapid progression and poor prognosis. Radiotherapy is one of the most effective treatments for EC. Three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) are 2 recently developed radiotherapy techniques. IMRT is believed to be more effective than 3D-CRT in target coverage, dose homogeneity, and reducing toxicity to normal organs. However, these advantages have not been demonstrated in the treatment of EC...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28766008/concurrent-paclitaxel-capecitabine-mitomycin-c-and-pelvic-radiation-therapy-for-patients-with-squamous-cell-anal-carcinoma
#19
Sergey S Gordeyev, Arsen O Rasulov, Vera A Gorbounova, Sergey I Tkachev, Valeriya V Glebovskaya, Mikhail Yu Fedyanin, Nataliya S Besova, Yulia E Surayeva
PURPOSE: The goals of this study were to assess safety and efficacy of triplet chemoradiotherapy (CRT) with paclitaxel for squamous cell anal carcinoma (SCAC). METHODS: Patients with stage I-IIIB SCAC were enrolled and received 52-58 Gy intensity-modulated radiotherapy (IMRT) (with dose based on the T stage) in consecutive daily 1.8-2.2 Gy fractions. The concurrent chemotherapy consisted of paclitaxel 45 mg/m(2) days 3, 10, 17, 24, 31, capecitabine 625 mg/m(2) bid on treatment days and mitomycin C 10 g/m(2) on day 1...
August 1, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28763877/-efficacy-of-pvd-regimen-combined-with-imrt-for-early-stage-extranodal-nasal-nk-t-cell-lymphoma
#20
Y Zhang, Y H Huang, Y F Hu, Q L Liu, T Wu
Objective: To evaluate the efficacy of PVD chemo-regimen (Pegaspargase, vincristine and dexamethasone) combined with intensity-modulated radiotherapy (IMRT) for patients with early-stage extranodal nasal NK/T-cell lymphoma (ENKL). Methods: Clinical data of 52 patients with early-stage ENKL were collected during May 2010 and June 2015 in Department of Lymphoma, Cancer Hospital of Guizhou Medical University, and these patients firstly received a concurrent chemoradiotherapy of two-cycle of PVD and IMRT (gross tumor volume primary: 12...
July 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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