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https://www.readbyqxmd.com/read/29453893/cbct-guided-evolutive-library-for-cervical-adaptive-imrt
#1
Bastien Rigaud, Antoine Simon, Maxime Gobeli, Caroline Lafond, Julie Leseur, Anais Barateau, Nicolas Jaksic, Joël Castelli, Danièle Williaume, Pascal Haigron, Renaud De Crevoisier
PURPOSE: In the context of adaptive radiation therapy (ART) for locally advanced cervical carcinoma (LACC), this study proposed an original cone-beam computed tomography (CBCT)-guided "Evolutive library" and evaluated it against four other known radiotherapy (RT) strategies. MATERIAL AND METHODS: For 20 patients who underwent intensity-modulated radiation therapy (IMRT) for LACC, three planning CTs (with empty [EB], intermediate [IB], and full [FB] bladder volumes), a CT scan at 20 Gy and bi-weekly CBCTs for 5 weeks were performed...
February 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29448308/perioperative-outcomes-and-survival-following-neoadjuvant-stereotactic-body-radiation-therapy-sbrt-versus-intensity-modulated-radiation-therapy-imrt-in-pancreatic-adenocarcinoma
#2
Brandon C Chapman, Ana Gleisner, Devin Rigg, Cheryl Meguid, Karyn Goodman, Brian Brauer, Csaba Gajdos, Richard D Schulick, Barish H Edil, Martin D McCarter
BACKGROUND AND OBJECTIVES: To compare outcomes in patients receiving neoadjuvant stereotactic body radiation therapy (SBRT) with those receiving intensity-modulated radiation therapy (IMRT) for pancreatic adenocarcinoma. METHODS: We analyzed patients receiving neoadjuvant SBRT for borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC) (2012-2016). Differences in baseline characteristics, perioperative outcomes, progression-free survival (PFS), and overall survival (OS) were compared...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29445299/choosing-wisely-after-publication-of-level-i-evidence-in-breast-cancer-radiotherapy
#3
Joshua R Niska, Sameer R Keole, Barbara A Pockaj, Michele Y Halyard, Samir H Patel, Donald W Northfelt, Richard J Gray, Nabil Wasif, Carlos E Vargas, William W Wong
Background: Recent trials in early-stage breast cancer support hypofractionated whole-breast radiotherapy (WBRT) as part of breast-conserving therapy (BCT). Evidence also suggests that radiotherapy (RT) omission may be reasonable for some patients over 70 years. Among radiation-delivery techniques, intensity-modulated RT (IMRT) is more expensive than 3-dimensional conformal RT (3DCRT). Based on this evidence, in 2013, the American Society for Radiation Oncology (ASTRO) recommended hypofractionated schedules for women aged ≥50 years with early-stage breast cancer and avoiding routine use of IMRT for WBRT...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29443390/tolerance-limits-and-methodologies-for-imrt-measurement-based-verification-qa-recommendations-of-aapm-task-group-no-218
#4
Moyed Miften, Arthur Olch, Dimitris Mihailidis, Jean Moran, Todd Pawlicki, Andrea Molineu, Harold Li, Krishni Wijesooriya, Jie Shi, Ping Xia, Nikos Papanikolaou, Daniel A Low
PURPOSE: Patient-specific IMRT QA measurements are important components of processes designed to identify discrepancies between calculated and delivered radiation doses. Discrepancy tolerance limits are neither well defined nor consistently applied across centers. The AAPM TG-218 report provides a comprehensive review aimed at improving the understanding and consistency of these processes as well as recommendations for methodologies and tolerance limits in patient-specific IMRT QA. METHODS: The performance of the dose difference/distance-to-agreement (DTA) and γ dose distribution comparison metrics are investigated...
February 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29441739/a-survey-of-radiation-therapy-utilization-in-korea-from-2010-to-2016-focusing-on-use-of-intensity-modulated-radiation-therapy
#5
Chai Hong Rim, Jeongshim Lee, Woo Chul Kim, DaeSik Yang, Won Sup Yoon, Woong Sub Koom, Chul Yong Kim
BACKGROUND: This study aimed to assess the recent changes of radiation therapy (RT) modalities in Korea. In particular, we focused on intensity-modulated radiation therapy (IMRT) utilization as the main index, presenting the application status of advanced RT. METHODS: We collected information from the Korean Health and Insurance Review and Assessment Service data based on the National Health Insurance Service claims and reimbursements records by using treatment codes from 2010 to 2016...
February 26, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29441419/modern-intensity-modulated-radiotherapy-with-image-guidance-allows-low-toxicity-rates-and-good-local-control-in-chemoradiotherapy-for-anal-cancer-patients
#6
Berardino De Bari, Laëtitia Lestrade, Alessandra Franzetti-Pellanda, Raphael Jumeau, Maira Biggiogero, Melpomeni Kountouri, Oscar Matzinger, Raymond Miralbell, Jean Bourhis, Mahmut Ozsahin, Thomas Zilli
PURPOSE: To report outcomes of a population of anal cancer patients treated with modern intensity-modulated radiotherapy and daily image-guided radiotherapy techniques. METHODS: We analyzed data of 155 patients consecutively treated with intensity-modulated radiotherapy +/- chemotherapy in three radiotherapy departments. One hundred twenty-two patients presented a stage II-IIIA disease. Chemotherapy was administered in 138 patients, mainly using mitomycin C and 5-fluorouracil (n = 81)...
February 13, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29439305/strategic-application-of-radiotherapy-for-hepatocellular-carcinoma
#7
Seo Hee Choi, Jinsil Seong
With increasing clinical use, radiotherapy (RT) has been considered reliable and effective method for hepatocellular carcinoma (HCC) treatment, depending on extent of disease and patient characteristics. RT for HCC can improve therapeutic outcomes through excellent local control, downstaging, conversion from unresectable to resectable status, and treatments of unresectable HCCs with vessel invasion or multiple intrahepatic metastases. In addition, further development of modern RT technologies, including image-guided radiotherapy (IGRT), intensity-modulated radiotherapy (IMRT), and stereotactic body radiotherapy, has expanded the indication of RT...
February 14, 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29436163/using-geud-based-plan-analysis-method-to-evaluate-proton-vs-photon-plans-for-lung-cancer-radiation-therapy
#8
Zhiyan Xiao, Wei J Zou, Ting Chen, Ning J Yue, Salma K Jabbour, Rahul Parikh, Miao Zhang
The goal of this study was to exam the efficacy of current DVH based clinical guidelines draw from photon experience for lung cancer radiation therapy on proton therapy. Comparison proton plans and IMRT plans were generated for 10 lung patients treated in our proton facility. A gEUD based plan evaluation method was developed for plan evaluation. This evaluation method used normal lung gEUD(a) curve in which the model parameter "a" was sampled from the literature reported value. For all patients, the proton plans delivered lower normal lung V5 Gy with similar V20 Gy and similar target coverage...
February 13, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29429963/impact-of-comorbidity-on-tolerability-and-survival-following-curative-intent-intensity-modulated-radiotherapy-in-older-patients-with-nasopharyngeal-cancer
#9
Kiattisa Sommat, Nelson Ling Fung Yit, Fuqiang Wang, John Heng Chi Lim
OBJECTIVE: This study aimed to evaluate the predictive factors for survival and acute toxicities in older patients with NPC treated with curative intent IMRT. MATERIALS AND METHODS: Older patients aged 65 years and above with non-metastatic NPC treated with curative intent IMRT between 2003 and 2013 were retrospectively analysed. Variables examined were gender, age, overall stage, chemotherapy use, Eastern Cooperative Oncology Group (ECOG) performance status and comorbidity...
February 9, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29429800/definite-chemoradiotherapy-is-a-competent-treatment-option-in-figo-stage-ib2-cervical-cancer-compared-with-radical-surgery-neoadjuvant-chemotherapy
#10
He-Yuan Hsieh, Jin-Wen Huang, Chien-Hsing Lu, Jin-Ching Lin, Lily Wang
BACKGROUND: To compare the treatment outcomes of different treatment modalities for International Federation of Gynecology and Obstetrics (FIGO) stage IB2 cervical cancer. METHODS: From January 2002 to July 2016, 91 patients with FIGO stage IB2 squamous cell carcinoma, adenocarcinoma or adenosquamous carcinoma of the cervix were enrolled. All of them received one of the following treatment modalities, including intensity-modulated radiotherapy (IMRT) with concurrent platinum-based chemotherapy (CCRT group, n = 27), radical surgery with or without adjuvant treatment (RH group, n = 25), or neoadjuvant chemotherapy followed by radical surgery with or without adjuvant treatment (NACT group, n = 39)...
February 8, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29429794/treatment-plan-quality-and-delivery-accuracy-assessments-on-3-imrt-delivery-methods-of-stereotactic-body-radiotherapy-for-spine-tumors
#11
Long Huang, Toufik Djemil, Tingliang Zhuang, Martin Andrews, Samuel T Chao, John H Suh, Ping Xia
Stereotactic body radiotherapy (SBRT) for spine tumors has demonstrated clinical effectiveness. The treatment planning and delivery techniques have evolved from dynamic conformal arc therapy, to fixed gantry angle intensity modulated radiotherapy (IMRT), and most recently to volumetric modulated arc therapy (VMAT). A hybrid-arc (HARC) planning and delivery method combining dynamic conformal arc therapy delivery with a number of equally spaced IMRT beams is proposed. In this study we investigated plan quality, delivery accuracy, and efficiency of 3 delivery techniques: IMRT, HARC, and VMAT...
February 8, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29428789/-re-irradiation-of-head-and-neck-cancers-target-volumes-technical-evolutions-and-prospects
#12
R Kinj, K Bénézery, C Florescu, B Gery, J L Habrand, J Thariat
Malignant tumors of the head and neck have a predominantly regional recurrence pattern, with most deaths resulting from this progression. Optimization of re-radiation in recurrence setting is a major objective for these patients. Extensive research has been carried out with the PubMed search engine to find publications dealing with this topic. The first attempts to reirradiate the ORL sphere date back to the 1980s and the first to be performed by intensity modulation conformational radiotherapy (IMRT) date back to the late 1990s...
February 7, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29427312/evaluation-of-surface-and-shallow-depth-dose-reductions-using-a-superflab-bolus-during-conventional-and-advanced-external-beam-radiotherapy
#13
Jihyung Yoon, Yibo Xie, Rui Zhang
The purpose of this study was to evaluate a methodology to reduce scatter and leakage radiations to patients' surface and shallow depths during conventional and advanced external beam radiotherapy. Superflab boluses of different thicknesses were placed on top of a stack of solid water phantoms, and the bolus effect on surface and shallow depth doses for both open and intensity-modulated radiotherapy (IMRT) beams was evaluated using thermoluminescent dosimeters and ion chamber measurements. Contralateral breast dose reduction caused by the bolus was evaluated by delivering clinical postmastectomy radiotherapy (PMRT) plans to an anthropomorphic phantom...
February 10, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29426342/dosimetric-comparison-between-proton-beam-therapy-and-photon-radiation-therapy-for-locally-advanced-esophageal-squamous-cell-carcinoma
#14
Yasuhiro Hirano, Masakatsu Onozawa, Hidehiro Hojo, Atsushi Motegi, Sadatomo Zenda, Kenji Hotta, Shunsuke Moriya, Hidenobu Tachibana, Naoki Nakamura, Takashi Kojima, Tetsuo Akimoto
BACKGROUND: The purpose of this study was to perform a dosimetric comparison between proton beam therapy (PBT) and photon radiation therapy in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who were treated with PBT in our institution. In addition, we evaluated the correlation between toxicities and dosimetric parameters, especially the doses to normal lung or heart tissue, to clarify the clinical advantage of PBT over photon radiation therapy. METHODS: A total of 37 consecutive patients with Stage III thoracic ESCC who had received PBT with or without concurrent chemotherapy between October 2012 and December 2015 were evaluated in this study...
February 9, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29416669/association-of-dna-repair-gene-polymorphisms-with-the-risk-of-radiation-pneumonitis-in-lung-cancer-patients
#15
Lehui Du, Wei Yu, Xiangkun Dai, Nana Zhao, Xiang Huang, Fang Tong, Fang Liu, Yurong Huang, Zhongjian Ju, Wei Yang, Xiaohu Cong, Chuanbin Xie, Xiaoliang Liu, Lanqing Liang, Yanan Han, Baolin Qu
A total of 149 lung cancer patients were recruited to receive intensity modulated radiation therapy (IMRT). The association of developing radiation pneumonitis (RP) with genetic polymorphism was evaluated. The risks of four polymorphic sites in three DNA repair related genes (ERCC1, rs116615:T354C and rs3212986:C1516A; ERCC2, rs13181:A2251C; XRCC1, rs25487:A1196G) for developing grade ≥ 2 RP were assessed respectively. It was observed that ERCC1 T354C SNP had a significant effect on the development of grade ≥ 2 RP (CT/TT vs...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29413274/volume-dose-and-fractionation-considerations-for-imrt-based-reirradiation-in-head-and-neck-cancer-a-multi-institution-analysis
#16
Jimmy J Caudell, Matthew C Ward, Nadeem Riaz, Sara J Zakem, Musaddiq J Awan, Neal E Dunlap, Derek Isrow, Comron Hassanzadeh, John A Vargo, Dwight E Heron, Samuel Marcrom, Drexell H Boggs, Chandana A Reddy, Joshua Dault, James A Bonner, Kristin A Higgins, Jonathan J Beitler, Shlomo A Koyfman, Mitchell Machtay, Min Yao, Andy M Trotti, Farzan Siddiqui, Nancy Y Lee
PURPOSE: Limited data exist to guide the treatment technique for reirradiation of recurrent or second primary squamous carcinoma of the head and neck. We performed a multi-institution retrospective cohort study to investigate the effect of the elective treatment volume, dose, and fractionation on outcomes and toxicity. METHODS AND MATERIALS: Patients with recurrent or second primary squamous carcinoma originating in a previously irradiated field (≥40 Gy) who had undergone reirradiation with intensity modulated radiation therapy (IMRT); (≥40 Gy re-IMRT) were included...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29412781/prognostic-model-for-stratification-of-radioresistant-nasopharynx-carcinoma-to-curative-salvage-radiotherapy
#17
You Quan Li, Yun Ming Tian, Sze Huey Tan, Ming Zhu Liu, Grace Kusumawidjaja, Enya H W Ong, Chong Zhao, Terence W K Tan, Kam Weng Fong, Kiattisa Sommat, Yoke Lim Soong, Joseph T S Wee, Fei Han, Melvin L K Chua
Purpose To investigate for a prognostic index (PI) to personalize recommendations for salvage intensity-modulated radiotherapy (IMRT) in patients with locally recurrent nasopharyngeal carcinoma (lrNPC). Methods Patients with lrNPC from two academic institutions (Sun Yat-Sen University Cancer Center [SYSUCC-A; n = 251 (training cohort)] and National Cancer Centre Singapore [NCCS; n = 114] and SYSUCC-B [n = 193 (validation cohorts)]) underwent salvage treatment with IMRT from 2001 to 2015. Primary and secondary clinical end points were overall survival (OS) and grade 5 toxicity-free rate (G5-TFR), respectively...
February 7, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29411526/assessment-of-multi-criteria-optimization-mco-for-volumetric-modulated-arc-therapy-vmat-in-hippocampal-avoidance-whole-brain-radiation-therapy-ha-wbrt
#18
Stephen Zieminski, Melin Khandekar, Yi Wang
This study compared the dosimetric performance of (a) volumetric modulated arc therapy (VMAT) with standard optimization (STD) and (b) multi-criteria optimization (MCO) to (c) intensity modulated radiation therapy (IMRT) with MCO for hippocampal avoidance whole brain radiation therapy (HA-WBRT) in RayStation treatment planning system (TPS). Ten HA-WBRT patients previously treated with MCO-IMRT or MCO-VMAT on an Elekta Infinity accelerator with Agility multileaf collimators (5-mm leaves) were re-planned for the other two modalities...
February 7, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29411506/a-simple-technique-to-improve-calculated-skin-dose-accuracy-in-a-commercial-treatment-planning-system
#19
Lilie Wang, Anthony J Cmelak, George X Ding
Radiation dermatitis during radiotherapy is correlated with skin dose and is a common clinical problem for head and neck and thoracic cancer patients. Therefore, accurate prediction of skin dose during treatment planning is clinically important. The objective of this study is to evaluate the accuracy of skin dose calculated by a commercial treatment planning system (TPS). We evaluated the accuracy of skin dose calculations by the anisotropic analytical algorithm (AAA) implemented in Varian Eclipse (V.11) system...
February 6, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29409516/cerebral-cortex-dose-sparing-for-glioblastoma-patients-imrt-versus-robust-treatment-planning
#20
Ann-Katrin Exeli, Daniel Kellner, Lukas Exeli, Phil Steininger, Frank Wolf, Felix Sedlmayer, Heinz Deutschmann
BACKGROUND: To date, patients with glioblastoma still have a bad median overall survival rate despite radiation dose-escalation and combined modality treatment. Neurocognitive decline is a crucial adverse event which may be linked to high doses to the cortex. In a planning study, we investigated the impact of dose constraints to the cerebral cortex and its relation to the organs at risk for glioblastoma patients. METHODS: Cortical sparing was implemented into the optimization process for two planning approaches: classical intensity-modulated radiotherapy (IMRT) and robust treatment planning...
February 6, 2018: Radiation Oncology
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