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https://www.readbyqxmd.com/read/29666822/accuracy-and-precision-of-a-veterinary-neuronavigation-system-for-radiation-oncology-positioning
#1
Isabelle F Vanhaezebrouck, Elizabeth A Ballegeer, Stephen Frey, Rob Sieffert
Conformal radiation treatment plans such as IMRT and other radiosurgery techniques require very precise patient positioning, typically within a millimeter of error for best results. CT cone beam, real-time navigation, and infrared position sensors are potential options for success but rarely present in veterinary radiation centers. A neuronavigation system (Brainsight Vet, Rogue Research) was tested 22 times on a skull for positioning accuracy and precision analysis. The first 6 manipulations allowed the authors to become familiar with the system but were still included in the analyses...
2018: Journal of Veterinary Medicine
https://www.readbyqxmd.com/read/29665327/adjuvant-radiotherapy-and-chemotherapy-improve-survival-in-patients-with-pancreatic-adenocarcinoma-receiving-surgery-adjuvant-chemotherapy-alone-is-insufficient-in-the-era-of-intensity-modulation-radiation-therapy
#2
Mao-Chih Hsieh, Wei-Wen Chang, Hsin-Hsien Yu, Chang-Yun Lu, Chia-Lun Chang, Jyh-Ming Chow, Shee-Uan Chen, Yunfeng Cheng, Szu-Yuan Wu
In the era of intensity modulation radiation therapy (IMRT), no prospective randomized trial has evaluated the efficacy of adjuvant therapies such as adjuvant concurrent chemoradiotherapy (CCRT), adjuvant sequential chemotherapy and radiotherapy (CT-RT), and adjuvant CT alone in resectable pancreatic adenocarcinoma (PA). Through propensity score matching, we designed a nationwide, population-based, head-to-head cohort study to determine the effects of dissimilar adjuvant treatments on resectable PA. We minimized the confounding of various adjuvant treatment outcomes among the following resectable PA groups of patients from the Taiwan Cancer Registry database: group 1, adjuvant CCRT; group 2, adjuvant sequential CT-RT; and group 3, adjuvant CT alone...
April 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29663431/a-novel-verification-method-using-a-plastic-scintillator-imagining-system-for-assessment-of-gantry-sag-in-radiotherapy
#3
Masato Tsuneda, Teiji Nishio, Akito Saito, Sodai Tanaka, Tatsuhiko Suzuki, Daisuke Kawahara, Keiichiro Matsushita, Aya Nishio, Shuichi Ozawa, Kumiko Karasawa, Yasushi Nagata
PURPOSE: High accuracy of the beam-irradiated position is required for high-precision radiation therapy such as stereotactic body radiation therapy (SBRT), volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT). Users generally perform the verification of the mechanical and radiation isocenters using the star shot test and the Winston Lutz test that allow evaluation of the displacement at the isocenter. However, these methods are unable to evaluate directly and quantitatively the sagging angle that is caused by the weight of the gantry itself along the gantry rotation axis...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29663429/remote-cherenkov-imaging-based-quality-assurance-of-a-magnetic-resonance-image-guided-radiotherapy-system
#4
Jacqueline M Andreozzi, Karen E Mooney, Petr Brůža, Austen Curcuru, David J Gladstone, Brian W Pogue, Olga Green
PURPOSE: Tools to perform regular quality assurance of magnetic resonance image-guided radiotherapy (MR-IGRT) systems should ideally be independent of interference from the magnetic fields. Remotely acquired optical Cherenkov imaging-based dosimetry measurements in water were investigated for this purpose, comparing measures of dose accuracy, temporal dynamics, and overall integrated IMRT delivery. METHODS: A 40x30.5x37.5cm3 water tank doped with 1g/L of quinine sulfate was imaged using an intensified charge coupled device (ICCD) to capture the Cherenkov emission while being irradiated by a commercial MR-IGRT system (ViewRay™ )...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29663405/a-career-path-for-pure-academic-medical-physicists-in-radiation-oncology-should-be-established
#5
Ke Sheng, Todd Pawlicki, Jing Cai
Medical physics research has led to many advanced radiation oncology technologies in the past decades, such as intensity modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT), and proton therapy. These have fundamentally shaped the current landscape of cancer treatment. It is believed that medical physics research will continue to play an essential role in advancing radiation oncology in the future. However, sustaining a healthy medical physics research workforce is facing substantial challenges, such as limited funding support and lack of protected research time...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29661254/the-risk-and-predictors-for-severe-radiation-pneumonitis-in-lung-cancer-patients-treated-with-thoracic-reirradiation
#6
Chengbo Ren, Tianlong Ji, Tingting Liu, Jun Dang, Guang Li
BACKGROUND: Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictors for severe RP in patients receiving thoracic re-RT. METHODS: Sixty seven patients with lung cancer received thoracic re-RT for recurrent or metastatic disease. Three-dimensional conformal radiotherapy (3D-CRT)/intensity modulated radiotherapy (IMRT) was used for 60 patients, and stereotactic body radiation therapy (SBRT) was used in 7 patients...
April 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29655708/salivary-flow-rate-after-conventional-and-intensity-modulated-radiation-therapy
#7
Caroline Tram Nguyen, Spencer Lin, Haley Clark, Allan Hovan, Jonn Wu
BACKGROUND: Conventional 3-dimensional conformal radiation therapy (3DCRT) for head and neck cancer (HNC) can cause hyposalivation, leading to caries and tooth extraction-related osteoradionecrosis. Intensity-modulated radiation therapy (IMRT) delivers more focused radiation than does 3DCRT. To reduce hyposalivation, the Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) guidelines limit salivary gland radiation dose. In this study, the authors compared the salivary flow rate in patients receiving 3DCRT and those receiving IMRT and evaluated the effect of their treatment satisfying the QUANTEC guidelines on hyposalivation...
April 11, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29651671/are-endometrial-cancer-radiotherapy-results-age-related
#8
Á Rovirosa, K S Cortés, C Ascaso, A Glickman, S Valdés, A Herreros, C Camacho, J Sánchez, Y Zhang, Y Li, S Sabater, M Arenas, A Torne
OBJECTIVE: To analyze the impact of age on radiotherapy results based on cancer-specific survival (CSS), vaginal-cuff relapses (VCR) and complications analysis in 438 patients with endometrial carcinoma (EC) receiving postoperative radiotherapy (PRT) divided into three age groups for analysis. MATERIALS AND METHODS: From 2003 to 2015, 438 patients with EC were treated with PRT and divided into three age groups: Group-1: 202 patients < 65 years; Group-2: 210 patients ≥ 65 and < 80 years; Group-3: 26 patients ≥ 80 years...
April 12, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29650035/image-guided-radiotherapy-reduces-the-risk-of-under-dosing-high-risk-prostate-cancer-extra-capsular-disease-and-improves-biochemical-control
#9
Per Munck Af Rosenschold, Michael J Zelefsky, Aditya P Apte, Andrew Jackson, Jung Hun Oh, Elliot Shulman, Neil Desai, Margie Hunt, Pirus Ghadjar, Ellen Yorke, Joseph O Deasy
BACKGROUND: To determine if reduced dose delivery uncertainty is associated with daily image-guidance (IG) and Prostate Specific Antigen Relapse Free Survival (PRFS) in intensity-modulated radiotherapy (IMRT) of high-risk prostate cancer (PCa). METHODS: Planning data for consecutive PCa patients treated with IMRT (n = 67) and IG-IMRT (n = 35) was retrieved. Using computer simulations of setup errors, we estimated the patient-specific uncertainty in accumulated treatment dose distributions for the prostate and for posterolateral aspects of the gland that are at highest risk for extra-capsular disease...
April 12, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29644809/optic-nerve-sheath-meningioma-preliminary-analysis-of-the-role-of-radiation-therapy
#10
Jun Jin, Jin Deok Joo, Jung Ho Han, Hee Kyung Yang, Jeong Min Hwang, Yi Jun Kim, In Ah Kim, Chae Yong Kim
BACKGROUND: The purpose of this study was to evaluate the treatment outcome of our optic nerve sheath meningioma (ONSM) case series in terms of preventing tumor growth and preserving vision in ONSM patients. METHODS: Between July 2003 and March 2015, 1,398 patients with intracranial meningioma were diagnosed at Seoul National University Bundang Hospital. Among them, only 13 patients (0.93%) were diagnosed with ONSM and enrolled in the present study. Tumor volume changes of ONSM patients and their visual acuity were evaluated before and after treatments...
April 2, 2018: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/29628628/a-treatment-planning-method-for-better-management-of-radiation-induced-oral-mucositis-in-locally-advanced-head-and-neck-cancer
#11
Hao Howard Zhang, Warren D D'Souza
Purpose/Aim: To describe a two-phase intensity-modulated radiation therapy (IMRT) treatment planning approach, that is, promising for reduction of oral mucositis risk in locally advanced head-and-neck cancer. Materials and Methods: Ten locally advanced head-and-neck cancer patients who underwent RT were retrospectively collected. Conventional IMRT and volumetric-modulated arc therapy (VMAT) plans were generated for these patients following clinical protocol. Following the first phase of generating conventional IMRT plans, our approach utilized data from Monte Carlo-based kernel superposition dose calculations corresponding to beam apertures (generated from the conventional IMRT plans) and used an exact mathematical programming-based optimization approach applying linear programming (LP) to dose optimization in the second phase...
January 2018: Journal of Medical Physics
https://www.readbyqxmd.com/read/29621873/set-up-errors-in-head-and-neck-cancer-treated-with-imrt-technique-assessed-by-cone-beam-computed-tomography-a-feasible-protocol
#12
Durim Delishaj, Stefano Ursino, Francesco Pasqualetti, Fabrizio Matteucci, Agostino Cristaudo, Carlo Pietro Soatti, Amelia Barcellini, Fabiola Paiar
PURPOSE: To investigate set-up errors, suggest the adequate planning target volume (PTV) margin and image-guided radiotherapy frequency in head and neck (H&N) cancer treated with intensity-modulated radiotherapy (IMRT) assessed by kV cone-beam computed tomography (CBCT). METHODS: We analyzed 360 CBCTs in 60 patients with H&N cancer treated with IMRT. The target delineation was contoured according to ICRU62. PTVs were generated by adding a 3-5 mm margin in all directions to the respective clinical target volumes...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29621872/dosimetric-comparison-of-imrt-versus-3dcrt-for-post-mastectomy-chest-wall-irradiation
#13
Kartick Rastogi, Shantanu Sharma, Shivani Gupta, Nikesh Agarwal, Sandeep Bhaskar, Sandeep Jain
PURPOSE: To compare the dose distribution of three-dimensional conformal radiation therapy (3DCRT) with intensity-modulated radiation therapy (IMRT) for post-mastectomy radiotherapy (PMRT) to left chest wall. MATERIALS AND METHODS: One hundred and seven patients were randomised for PMRT in 3DCRT group (n = 64) and IMRT group (n = 43). All patients received 50 Gy in 25 fractions. Planning target volume (PTV) parameters-Dnear-max (D2 ), Dnear-min (D98 ), Dmean , V95 , and V107 -homogeneity index (HI), and conformity index (CI) were compared...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29621869/intensity-modulated-radiation-therapy-a-review-with-a-physics-perspective
#14
REVIEW
Byungchul Cho
Intensity-modulated radiation therapy (IMRT) has been considered the most successful development in radiation oncology since the introduction of computed tomography into treatment planning that enabled three-dimensional conformal radiotherapy in 1980s. More than three decades have passed since the concept of inverse planning was first introduced in 1982, and IMRT has become the most important and common modality in radiation therapy. This review will present developments in inverse IMRT treatment planning and IMRT delivery using multileaf collimators, along with the associated key concepts...
March 2018: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29618938/bimodality-treatment-of-patients-with-pelvic-adenoid-cystic-carcinoma-with-photon-intensity-modulated-radiotherapy-plus-carbon-ion-boost-a-case-series
#15
Denise Bernhardt, Florian Sterzing, Sebastian Adeberg, Klaus Herfarth, Sonja Katayama, Robert Foerster, Juliane Hoerner-Rieber, Laila König, Juergen Debus, Stefan Rieken
Background: Treatment of patients with pelvic adenoid cystic carcinoma (ACC) remains a challenge owing to the rarity of the disease, the lack of data, and the relative radioresistance of these tumors. Case reports: This case series presents the results of three patients with recurrent or inoperable pelvic ACC treated with intensity-modulated radiotherapy (IMRT) plus carbon ion (C12) boost. Patients received C12 therapy at a dose of 3 Gray equivalents (GyE) (relative biological effectiveness [RBE]) per fraction up to 24 GyE RBE, followed by 50 GyE of photon IMRT in 25 fractions...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29618828/results-of-the-radiation-dose-of-head-body-and-tail-of-hippocampus-in-nasopharyngeal-carcinoma-patients-treated-with-intensity-modulated-radiotherapy
#16
Sun Zong-Wen, Shi Lei, Li Qinglin, Kong Yue, Du Feng-Lei, Xie Tie-Ming, Hua Yong-Hong, Hu Qiao-Ying, Chen Xiao-Zhong, Chen Yuan-Yuan, Chen Ming
This study is to analyze the radiation dose of head, body and tail of hippocampus (HC) of nasopharyngeal carcinoma (NPC) patients treated with intensity modulated radiotherapy (IMRT). Evaluate cognitive function of patients with Wechsler adult intelligence scale-Chinese revised (WAIS-CR). HC were segmented into HC head (HH), HC body (HB) and HC tail (HT) and the indexes were then analyzed. WAIS-CR was tested before and 3months after radiotherapy. The mean radiation dose of left and right HC was (1147 ± 976)cGy, (1011 ± 602)cGy respectively...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29616187/an-ensemble-approach-to-knowledge-based-intensity-modulated-radiation-therapy-planning
#17
Jiahan Zhang, Q Jackie Wu, Tianyi Xie, Yang Sheng, Fang-Fang Yin, Yaorong Ge
Knowledge-based planning (KBP) utilizes experienced planners' knowledge embedded in prior plans to estimate optimal achievable dose volume histogram (DVH) of new cases. In the regression-based KBP framework, previously planned patients' anatomical features and DVHs are extracted, and prior knowledge is summarized as the regression coefficients that transform features to organ-at-risk DVH predictions. In our study, we find that in different settings, different regression methods work better. To improve the robustness of KBP models, we propose an ensemble method that combines the strengths of various linear regression models, including stepwise, lasso, elastic net, and ridge regression...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29611210/interplay-effect-on-a-6-mv-flattening-filter-free-linear-accelerator-with-high-dose-rate-and-fast-multi-leaf-collimator-motion-treating-breast-and-lung-phantoms
#18
Tucker Netherton, Yuting Li, Paige Nitsch, Simona Shaitelman, Peter Balter, Song Gao, Ann Klopp, Manickam Muruganandham, Laurence Court
PURPOSE: Using a new linear accelerator with high dose rate (800 MU/min), fast MLC motions (5.0cm/s), fast gantry rotation (15sec/rotation), and 1cm wide MLCs, we aimed to quantify the effects of complexity, arc number, and fractionation on interplay for breast and lung treatments under target motion. METHODS: To study lung interplay, eight VMAT plans (one to six arcs) and four nine-field sliding-window IMRT plans varying in complexity were created. For the breast plans, four four-field sliding-window IMRT plans were created...
April 2, 2018: Medical Physics
https://www.readbyqxmd.com/read/29609812/correlation-between-gamma-passing-rate-and-complexity-of-imrt-plan-due-to-mlc-position-errors
#19
Yewei Wang, Xueying Pang, Lina Feng, Helong Wang, Yanling Bai
PURPOSE: This study evaluates the correlation between the susceptibility of the γ passing rate of IMRT plans to the multi-leaf collimator (MLC) position errors and a quantitative plan complexity metric. METHODS: Twenty patients were selected for this study. For each patient, two IMRT plans were generated using sliding window and step-&-shoot techniques, respectively. Modulation complexity score (MCS) was calculated for all IMRT plans, and symmetric MLC leaf bank errors, ranging from 0...
March 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29608256/aging-related-prognosis-analysis-of-definitive-radiotherapy-for-very-elderly-esophageal-cancer
#20
Yong-Chun Zhou, Li-Li Chen, Hong-Bo Xu, Qian Sun, Qi Zhang, Han-Fei Cai, Hao Jiang
Because of the exclusion for the patients more than 75 years (very elderly patients) in many clinical trials of esophageal cancer (EC), there is no consensus on prognosis and treatment for this population. We aim to evaluate the outcomes and aging-related prognostic factors of definitive radiotherapy (RT) for very elderly EC patients. We retrospectively analyzed 149 very elderly EC patients consecutively treated between January 2015 and June 2016 by definitive intensity-modulated radiotherapy (IMRT) with or without chemotherapy...
April 2, 2018: Cancer Medicine
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