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https://www.readbyqxmd.com/read/28106658/transoral-surgery-vs-intensity-modulated-radiotherapy-for-early-supraglottic-cancer-a-systematic-review
#1
Mark S Swanson, Garren Low, Uttam K Sinha, Niels Kokot
PURPOSE OF REVIEW: To provide clinicians with a critical review of outcomes for endolaryngeal surgery and intensity-modulated radiation therapy (IMRT) for early-stage supraglottic cancer. RECENT FINDINGS: A total of 971 potential articles were reviewed, with inclusion of 14 studies comparing IMRT with transoral surgery. One study analyzed IMRT, one transoral robotic surgery, and the remaining were transoral laser microsurgery studies. A weighted average and 95% confidence interval of all surgery patients showed a local control of 90...
January 18, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28105886/interobserver-delineation-uncertainty-in-involved-node-radiation-therapy-inrt-for-early-stage-hodgkin-lymphoma-on-behalf-of-the-radiotherapy-committee-of-the-eortc-lymphoma-group
#2
Marianne C Aznar, Theodore Girinsky, Anne Kiil Berthelsen, Berthe Aleman, Max Beijert, Martin Hutchings, Yolande Lievens, Paul Meijnders, Peter Meidahl Petersen, Deborah Schut, Maja V Maraldo, Richard van der Maazen, Lena Specht
BACKGROUND AND PURPOSE: In early-stage classical Hodgkin lymphoma (HL) the target volume nowadays consists of the volume of the originally involved nodes. Delineation of this volume on a post-chemotherapy CT-scan is challenging. We report on the interobserver variability in target volume definition and its impact on resulting treatment plans. MATERIALS AND METHODS: Two representative cases were selected (1: male, stage IB, localization: left axilla; 2: female, stage IIB, localizations: mediastinum and bilateral neck)...
January 20, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28103970/-a-phase-i-ii-study-of-chemotherapy-concurrent-with-twice-daily-radiotherapy-%C3%A2-schedules-by-intensity-modulated-radiation-therapy-using-simultaneous-integrated-boost-for-limited-stage-small-cell-lung-cancer
#3
Jing You, Huiming Yu, Maxiaowei Song, Chen Shi, Xiaohang Wang, Ye Zheng, Rong Yu, Anhui Shi, Guangying Zhu
BACKGROUND: Twice-daily radiation concurrent with chemotherapy is one of the standard methods for limited-stage small cell lung cancer. The study was to evaluate the feasibility of chemotherapy concurrent with dose-escalating twice-daily radiotherapy by simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) approach in patients with limited-stage small cell lung cancer. METHODS: Patients with limited-stage small cell lung cancer were included, treated with twice-daily radiotherapy by SIB-IMRT concurrent with chemotherapy of etoposide plus cisplatin...
January 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28100239/elective-breast-radiotherapy-including-level-i-and-ii-lymph-nodes-a-planning-study-with-the-humeral-head-as-planning-risk-volume
#4
Kathrin Surmann, Jorien van der Leer, Tammy Branje, Maurice van der Sangen, Maarten van Lieshout, Coen W Hurkmans
BACKGROUND: The aim of this study was to assess the dose to the humeral head planning risk volume with the currently used high tangential fields (HTF) and compare different planning techniques for breast radiotherapy including axillary level I and II lymph nodes (PTVn) while sparing the humeral head. METHODS: Ten patients with left-sided breast cancer were enrolled in a planning study with 16 fractions of 2.66 Gy. Four planning techniques were compared: HTF, HTF with sparing of the humeral head, 6-field IMRT with sparing of the humeral head and VMAT with sparing of the humeral head...
January 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28094212/sparing-of-high-retropharyngeal-nodal-basins-in-patients-with-unilateral-oropharyngeal-carcinoma-treated-with-intensity-modulated-radiation-therapy
#5
Jonathan E Leeman, Stanley Gutiontov, Paul Romesser, Sean McBride, Nadeem Riaz, Nancy Lee, C Jillian Tsai
PURPOSE: The introduction of intensity modulated radiotherapy (IMRT) has facilitated dose painting and sparing of uninvolved/low-risk nodal basins in head and neck cancers. In oropharynx cancer (OPC), the need for elective coverage of uninvolved high contralateral retropharyngeal (RP) nodes and the risk associated with sparing this region remain unclear. We examined outcomes of OPC patients treated with IMRT and omission of contralateral high RP coverage. METHODS AND MATERIALS: We identified 102 OPC patients with cN0-N2b disease treated with definitive IMRT with or without concurrent chemotherapy between 2010 and 2013...
November 11, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28093791/local-therapy-improves-overall-survival-in-patients-with-newly-diagnosed-metastatic-prostate-cancer
#6
Rahul R Parikh, John Byun, Sharad Goyal, Isaac Yi Kim
BACKGROUND: The role of local therapy, in the form of radiation therapy (RT) or radical prostatectomy(RP), and its association on outcomes is not well established in patients with metastatic prostate cancer. METHODS: Using the National Cancer Database (NCDB), we evaluated patterns of care and outcomes among patients diagnosed with metastatic prostate cancer from 2004 to 2013 treated with local therapy (RP, intensity-modulated radiation therapy [IMRT], or 2D/3D-conformal radiation therapy [CRT])...
January 17, 2017: Prostate
https://www.readbyqxmd.com/read/28091874/the-influence-of-dental-treatment-on-the-development-of-osteoradionecrosis-after-radiotherapy-by-modern-irradiation-techniques
#7
Ramona Schweyen, Andreas Stang, Andreas Wienke, Alexander Eckert, Thomas Kuhnt, Jeremias Hey
OBJECTIVES: The aim of this study was to analyze the influence of dental treatment on the development of osteoradionecrosis (ORN) of the jaw. METHODS: This study included the data of 776 patients who underwent 3D-CRT or IMRT because of head and neck cancer. Sex, dental status before and after radiotherapy (RT), tumor site, bone surgery during tumor operation, concomitant chemotherapy, and the development of an advanced ORN were documented for each patient. The patients' dentitions before and after RT were classified into four groups with regard to the number and localization of the remaining teeth...
January 13, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28089602/particle-swarm-optimizer-for-weighting-factor-selection-in-intensity-modulated-radiation-therapy-optimization-algorithms
#8
Jie Yang, Pengcheng Zhang, Liyuan Zhang, Huazhong Shu, Baosheng Li, Zhiguo Gui
In inverse treatment planning of intensity-modulated radiation therapy (IMRT), the objective function is typically the sum of the weighted sub-scores, where the weights indicate the importance of the sub-scores. To obtain a high-quality treatment plan, the planner manually adjusts the objective weights using a trial-and-error procedure until an acceptable plan is reached. In this work, a new particle swarm optimization (PSO) method which can adjust the weighting factors automatically was investigated to overcome the requirement of manual adjustment, thereby reducing the workload of the human planner and contributing to the development of a fully automated planning process...
January 12, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28086954/a-comparative-analysis-between-sequential-boost-and-integrated-boost-intensity-modulated-radiation-therapy-with-concurrent-chemotherapy-for-locally-advanced-head-and-neck-cancer
#9
Gregory Vlacich, Mark J Stavas, Praveen Pendyala, Shaeu-Chiann Chen, Yu Shyr, Anthony J Cmelak
BACKGROUND: Planning and delivery of IMRT for locally advanced head and neck cancer (LAHNC) can be performed using sequential boost or simultaneous integrated boost (SIB). Whether these techniques differ in treatment-related outcomes including survival and acute and late toxicities remain largely unexplored. METHODS: We performed a single institutional retrospective matched cohort analysis on patients with LAHNC treated with definitive chemoradiotherapy to 69.3 Gy in 33 fractions...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28077128/treatment-planning-comparison-of-impt-vmat-and-4%C3%AF-radiotherapy-for-prostate-cases
#10
Angelia Tran, Jingjing Zhang, Kaley Woods, Victoria Yu, Dan Nguyen, Gary Gustafson, Lane Rosen, Ke Sheng
BACKGROUND: Intensity-modulated proton therapy (IMPT), non-coplanar 4π intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) represent the most advanced treatment methods based on heavy ion and X-rays, respectively. Here we compare their performance for prostate cancer treatment. METHODS: Ten prostate patients were planned using IMPT with robustness optimization, VMAT, and 4π to an initial dose of 54 Gy to a clinical target volume (CTV) that encompassed the prostate and seminal vesicles, then a boost prescription dose of 25...
January 11, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28076338/quantification-of-confounding-factors-in-mri-based-dose-calculations-as-applied-to-prostate-imrt
#11
Matteo Maspero, Peter R Seevinck, Gerald Schubert, Michaela A U Hoesl, Bram van Asselen, Max A Viergever, Jan J W Lagendijk, Gert J Meijer, Cornelis A T van den Berg
Magnetic resonance (MR)-only radiotherapy treatment planning requires pseudo-CT (pCT) images to enable MR-based dose calculations. To verify the accuracy of MR-based dose calculations, institutions interested in introducing MR-only planning will have to compare pCT-based and computer tomography (CT)-based dose calculations. However, interpreting such comparison studies may be challenging, since potential differences arise from a range of confounding factors which are not necessarily specific to MR-only planning...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28075206/hydrogel-rectum-prostate-spacers-mitigate-the-uncertainties-in-proton-relative-biological-effectiveness-associated-with-anterior-oblique-beams
#12
Tracy S A Underwood, Justin C Voog, Maryam Moteabbed, Shikui Tang, Edward Soffen, Oren Cahlon, Hsiao-Ming Lu, Anthony L Zietman, Jason A Efstathiou, Harald Paganetti
AIM: Anterior-oblique (AO) proton beams can form an attractive option for prostate patients receiving external beam radiotherapy (EBRT) as they avoid the femoral heads. For a cohort with hydrogel prostate-rectum spacers, we asked whether it was possible to generate AO proton plans robust to end-of-range elevations in linear energy transfer (LET) and modeled relative biological effectiveness (RBE). Additionally we considered how rectal spacers influenced planned dose distributions for AO and standard bilateral (SB) proton beams versus intensity-modulated radiotherapy (IMRT)...
January 11, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28072395/evaluation-of-adaptive-treatment-planning-for-patients-with-non-small-cell-lung-cancer
#13
Hualiang Zhong, Salim Siddiqui, Benjamin Movsas, Indrin Chetty
The purpose of this study was to develop metrics to evaluate uncertainties in deformable dose accumulation (DDA) for patients with non-small cell lung cancer (NSCLC). Initial treatment plans (primary) and cone-beam CT (CBCT) images were retrospectively processed for seven NSCLC patients, who showed significant tumor regression during the course of treatment. Each plan was developed with IMRT for 2 Gy��33 fractions. A B-spline-based DIR algorithm was used to register weekly CBCT images to a reference image acquired at fraction 21 and the resultant displacement vector fields (DVFs) were then modified using a finite element method (FEM)...
January 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28070838/late-toxicity-evolving-radiotherapy-techniques-and-quality-of-life-in-nasopharyngeal-carcinoma
#14
Luciana Lastrucci, Silvia Bertocci, Vittorio Bini, Simona Borghesi, Roberta De Majo, Andrea Rampini, Paola Pernici, Pietro Giovanni Gennari
PURPOSE: To analyze quality of life (QoL) and functional state (FS) by patient-reported outcome (PRO) questionnaires (FACT-G, FACT-NP, PSS-HN, XeQOLS, and EQ-5D-3L) in long-term survivors nasopharyngeal carcinoma (NPC) treated with conventional radiotherapy (RT) and intensity modulated radiotherapy (IMRT). METHODS: 25 patients answered to five questionnaires about QoL and FS. All patients were assessed also for late toxicity. RESULTS: Functional Assessment of Cancer Therapy-General (FACT-G) and Performance Status Scale Head and Neck (PSS-HN) scores were significantly elevated (better QoL) in age <50 years (p = 0...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28068238/hematologic-nadirs-during-chemoradiation-for-anal-cancer-temporal-characterization-and-dosimetric-predictors
#15
Andrew Y Lee, Daniel W Golden, Jose G Bazan, Malgorzata Kopec, Charles A Pelizzari, Sonya Aggarwal, Daniel T Chang, Stanley L Liauw
PURPOSE: Pelvic bone marrow (BM) constraints may offer a means to reduce the toxicity commonly associated with chemoradiation for anal cancer. We conducted a bi-institutional analysis of dose-volume metrics in a time-sensitive fashion to devise practical metrics to minimize hematologic toxicity. METHODS AND MATERIALS: Fifty-six anal cancer patients from 2 institutions received definitive radiation therapy (median primary dose of 54 Gy) using intensity modulated radiation therapy (IMRT, n=49) or 3-dimensional (3D) conformal therapy (n=7) with concurrent 5-fluorouracil (5-FU) and mitomycin C...
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28065699/evaluation-of-mlc-performance-in-vmat-and-dynamic-imrt-by-log-file-analysis
#16
José Olasolo-Alonso, Alejandro Vázquez-Galiñanes, Santiago Pellejero-Pellejero, José Fernando Pérez-Azorín
PURPOSE: This multi-institution study assessed the positioning accuracy of multileaf collimators (MLC) by analyzing log files. It determined the main machine parameters that affect MLC positioning errors for pre-TrueBeam (Clinac) and TrueBeam linacs. METHODS: Around 30,000 dIMRT and VMAT log files belonging to 6 linacs from 4 different centers were analyzed. An in-house software was used to calculate 95th percentile and RMS error values and their correlation with certain parameters such as maximum leaf speed, mean leaf speed and gantry angle...
January 5, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28063696/association-of-post-treatment-positron-emission-tomography-with-locoregional-control-and-survival-after-radiation-therapy-for-squamous-cell-carcinoma-of-the-vulva
#17
Yuan James Rao, Comron Hassanzadeh, Anupama Chundury, Caressa Hui, Barry A Siegel, Farrokh Dehdashti, Todd DeWees, Daniel Mullen, Matthew A Powell, David G Mutch, Julie K Schwarz, Perry W Grigsby
BACKGROUND/PURPOSE: The aim of this study was to investigate the use of post-treatment F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for vulvar cancer and compare metabolic response to clinical outcomes. MATERIALS/METHODS: This retrospective study included 21 patients with vulvar squamous cell carcinoma treated with curative-intent radiation between 2007 and 2015. All patients received intensity-modulated radiation treatment (IMRT), a pre-treatment FDG/PET-CT, and a post-treatment FDG-PET/CT performed at a median time of 3months post-IMRT...
January 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28061474/tomotherapy-as-an-adjuvant-treatment-for-gastroesophageal-junction-and-stomach-cancer-may-reduce-bowel-and-bone-marrow-toxicity-compared-to-intensity-modulated-radiotherapy-and-volumetric-modulated-arc-therapy
#18
Xin Wang, Yuan Tian, Yuan Tang, Zhi-Hui Hu, Jia-Jia Zhang, Gui-Shan Fu, Pan Ma, Hua Ren, Tao Zhang, Ning Li, Wen-Yang Liu, Hui Fang, Ye-Xiong Li, Jing Jin
PURPOSE: To compare dosimetric parameters of intensity-modulated radiotherapy (IMRT), volumetric-modulated arc therapy (VMAT) and tomotherapy (TOMO) in the adjuvant treatment of gastroesophageal junction (GEJ)/stomach cancer. The planning goal was to maintain high target coverage while keeping the dose to the bowel and bone marrow (BM) as low as possible. MATERIALS AND METHODS: After curative surgery, 16 patients with GEJ/stomach cancer were re-planned by coplanar IMRT (five fixed beam), VMAT (double-arc), and TOMO...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28059560/dose-specification-for-hippocampal-sparing-whole-brain-radiotherapy-hs-wbrt-considerations-from-the-uk-hippo-trial-qa-programme
#19
Daniel Megias, Mark Phillips, Laura Clifton-Hadley, Elizabeth Harron, David J Eaton, Paul Sanghera, Gillian Whitfield
OBJECTIVES: The HIPPO trial is a UK randomised phase II trial of Hippocampal Sparing (HS) versus Conventional Whole Brain Radiotherapy after surgical resection or radiosurgery in favourable prognosis patients with 1-4 brain metastases. Each participating centre completed a planning benchmark case as part of the dedicated radiotherapy trials quality assurance programme (RTQA), promoting the safe and effective delivery of HS Intensity Modulated Radiotherapy (IMRT) in a multi-centre trial setting...
January 6, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28056518/mucosal-sparing-radiation-therapy-in-resected-oropharyngeal-cancer
#20
Mauricio E Gamez, Michele Y Halyard, Michael L Hinni, Richard E Hayden, Thomas H Nagel, Carlos E Vargas, William W Wong, Kelly K Curtis, Matthew A Zarka, Daniel Ma, Samir H Patel
PURPOSE: To report the outcomes of patients with favorable risk oropharyngeal cancer that underwent adjuvant radiation therapy with omission of the primary site from the clinical target volume (CTV). MATERIAL/METHODS: A retrospective study of 40 patients treated with transoral surgery (TOS) followed by neck only radiation using intensity modulated radiation therapy (IMRT) with exclusion of the primary site. For all patients, a CTV of the primary surgical bed was contoured to obtain the estimated incidental dose to the primary site...
December 1, 2016: Annals of Otology, Rhinology, and Laryngology
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