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https://www.readbyqxmd.com/read/29037023/simultaneous-integrated-boost-intensity-modulated-radiotherapy-versus-3-dimensional-conformal-radiotherapy-in-preoperative-concurrent-chemoradiotherapy-for-locally-advanced-rectal-cancer
#1
Bong Kyung Bae, Min Kyu Kang, Jae-Chul Kim, Mi Young Kim, Gyu-Seog Choi, Jong Gwang Kim, Byung Woog Kang, Hye Jin Kim, Soo Yeun Park
PURPOSE: To evaluate the feasibility of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) for preoperative concurrent chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC), by comparing with 3-dimensional conformal radiotherapy (3D-CRT). MATERIALS AND METHODS: Patients who were treated with PCRT for LARC from 2015 January to 2016 December were retrospectively enrolled. Total doses of 45 Gy to 50.4 Gy with 3D-CRT or SIB-IMRT were administered concomitantly with 5-fluorouracil plus leucovorin or capecitabine...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29035618/impact-of-intensity-modulated-radiotherapy-on-health-care-costs-of-patients-with-anal-squamous-cell-carcinoma
#2
Alexander L Chin, Erqi L Pollom, Yushen Qian, Albert C Koong, Daniel T Chang
PURPOSE: Drivers of variation in the cost of care after chemoradiotherapy for the management of anal squamous cell carcinoma (SCC) have not been fully elucidated. We sought to characterize the direct and indirect impact of radiotherapy modality on health care costs among patients with anal SCC. PATIENTS AND METHODS: A retrospective cohort study was performed using the 2014 linkage of the SEER-Medicare database. We identified 1,025 patients with anal SCC diagnosed between 2001 and 2011 and treated with chemoradiotherapy...
October 16, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29034992/combined-prognostic-value-of-pretreatment-anemia-and-cervical-node-necrosis-in-patients-with-nasopharyngeal-carcinoma-receiving-intensity-modulated-radiotherapy-a-large-scale-retrospective-study
#3
Lu-Lu Zhang, Guan-Qun Zhou, Yi-Yang Li, Ling-Long Tang, Yan-Ping Mao, Ai-Hua Lin, Jun Ma, Zhen-Yu Qi, Ying Sun
This study investigated the combined prognostic value of pretreatment anemia and cervical node necrosis (CNN) in patients with nasopharyngeal carcinoma (NPC). Retrospective review of 1302 patients with newly diagnosed nonmetastatic NPC treated with intensity-modulated radiotherapy (IMRT) ± chemotherapy. Patients were classified into four groups according to anemia and CNN status. Survival was compared using the log-rank test. Independent prognostic factors were identified using the Cox proportional hazards model...
October 16, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29031904/definitive-radiotherapy-for-a-head-and-neck-merkel-cell-carcinoma-and-comprehensive-nodal-volumes-a-case-for-using-a-computer-designed-variable-thickness-compensator-to-reduce-risk-and-severity-of-mucositis
#4
Anesa Ahamad, Donald T Weed, Darel D Pruett, Daniel Saulpaugh, Womah Neeranjun, Eduardo Fernandez
When contemplating how to treat head and neck primary cancers and regional lymph nodes with radiotherapy, we often select the contemporary intensity-modulated radiotherapy (IMRT) without much consideration of older methods that may give fewer side effects and be more cost-effective. For an 87-year-old female with a 1.5-cm Merkel cell carcinoma (MCC) located 1.5 cm lateral to the orbital rim, we were challenged to deliver 50 Gy to comprehensive elective nodal regions and 70 Gy to the primary. We were particularly concerned about the potential adverse acute effects of radiotherapy to mucosal structures in this elderly female...
October 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29031609/multi-atlas-based-segmentation-of-prostatic-urethra-from-planning-ct-imaging-to-quantify-dose-distribution-in-prostate-cancer-radiotherapy
#5
Oscar Acosta, Eugenia Mylona, Mathieu Le Dain, Camille Voisin, Thibaut Lizee, Bastien Rigaud, Carolina Lafond, Khemara Gnep, Renaud de Crevoisier
BACKGROUND AND PURPOSE: Segmentation of intra-prostatic urethra for dose assessment from planning CT may help explaining urinary toxicity in prostate cancer radiotherapy. This work sought to: i) propose an automatic method for urethra segmentation in CT, ii) compare it with previously proposed surrogate models and iii) quantify the dose received by the urethra in patients treated with IMRT. MATERIALS AND METHODS: A weighted multi-atlas-based urethra segmentation method was devised from a training data set of 55 CT scans of patients receiving brachytherapy with visible urinary catheters...
October 11, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29031556/corrigendum-to-long-term-results-of-a-phase-ii-study-of-gemcitabine-and-cisplatin-chemotherapy-combined-with-intensity-modulated-radiotherapy-in-locoregionally-advanced-nasopharyngeal-carcinoma-oral-oncol-73-2017-118-123
#6
Mingyao Wu, Dan Ou, Xiayun He, Chaosu Hu
OBJECTIVES: To evaluate long-term results of a phase II study of induction and adjuvant gemcitabine and cisplatin (GP) chemotherapy with intensity-modulated radiotherapy (IMRT) in locoregionally advanced nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: One hundred and twelve patients (Stage III: 65, IVA-B: 47) with locoregionally advanced NPC were enrolled in this study. All patients received induction chemotherapy consisting of 1000 mg/m(2) gemcitabine on day 1 and 8, and cisplatin 25 mg/m(2) on day 1-3, every 3 weeks for 2 cycles...
October 11, 2017: Oral Oncology
https://www.readbyqxmd.com/read/29030906/effects-of-interruptions-of-external-beam-radiation-therapy-on-outcomes-in-patients-with-prostate-cancer
#7
Yanqun Dong, Nicholas G Zaorsky, Tianyu Li, Thomas M Churilla, Rosalia Viterbo, Mark L Sobczak, Marc C Smaldone, David Yt Chen, Robert G Uzzo, Mark A Hallman, Eric M Horwitz
INTRODUCTION: To evaluate if interruptions of external beam radiation therapy impact outcomes in men with localized prostate cancer (PCa). METHODS: We included men with localized PCa treated with three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiation therapy (IMRT) of escalated dose (≥74 Gy in 1.8 or 2 Gy fractions) between 1992 and 2013 at an NCI-designated cancer centre. Men receiving androgen deprivation therapy were excluded. The non-treatment day ratio (NTDR) was defined as the number of non-treatment days divided by the total elapsed days of therapy...
October 13, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29030203/characterization-and-clinical-evaluation-of-a-novel-2d-detector-array-for-conventional-and-flattening-filter-free-fff-imrt-pre-treatment-verification
#8
Yuvaraj Sekar, Johannes Thoelking, Miriam Eckl, Irakli Kalichava, Dwi Seno Kuncoro Sihono, Frank Lohr, Frederik Wenz, Hansjoerg Wertz
BACKGROUND AND PURPOSE: The novel MatriXX(FFF) (IBA Dosimetry, Germany) detector is a new 2D ionization chamber detector array designed for patient specific IMRT-plan verification including flattening-filter-free (FFF) beams. This study provides a detailed analysis of the characterization and clinical evaluation of the new detector array. MATERIAL AND METHODS: The verification of the MatriXX(FFF) was subdivided into (i) physical dosimetric tests including dose linearity, dose rate dependency and output factor measurements and (ii) patient specific IMRT pre-treatment plan verifications...
October 10, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29027125/a-survey-of-modulated-radiotherapy-use-in-australia-new-zealand-in-2015
#9
Jeffrey Barber, Philip Vial, Paul White, Nick Menzies, Shrikant Deshpande, Regina Bromley, Nick Bennie, Shan Yau, Kristie Harrison
A survey of radiation oncology medical physics departments across Australia and New Zealand was conducted to assess the usage, commissioning and quality assurance of modulated radiotherapy techniques such as IMRT and VMAT. Survey responses were collected in April-May 2015 to snapshot current practice and historical implementation. The survey asked 142 questions, and is the most detailed survey of its kind published to date. Analysis of results at overall department level, as well as sub-analysis for different equipment and techniques in use, was performed...
October 12, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29025277/clinical-analysis-of-recurrence-patterns-in-patients-with-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#10
Lijun Wang, Yesong Guo, Jianhua Xu, Zhenzhang Chen, Xuesong Jiang, Lanfang Zhang, Shengfu Huang, Xia He, Yiqin Zhang
OBJECTIVE: To evaluate the characteristics and risk factors for locoregional recurrence in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT). METHODS: The clinical diagnosis and treatment data of 195 patients with NPC treated with IMRT from March 2005 to May 2010 (including 9, 24, 70, and 92 cases of stage I, II, III, and IV disease, respectively, according to the 7th edition American Joint Committee on Cancer staging criteria) were retrospectively analyzed...
October 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29024297/reducing-dose-to-the-lungs-through-loosing-target-dose-homogeneity-requirement-for-radiotherapy-of-non-small-cell-lung-cancer
#11
Junjie Miao, Hui Yan, Yuan Tian, Pan Ma, Zhiqiang Liu, Minghui Li, Wenting Ren, Jiayun Chen, Ye Zhang, Jianrong Dai
It is important to minimize lung dose during intensity-modulated radiation therapy (IMRT) of nonsmall cell lung cancer (NSCLC). In this study, an approach was proposed to reduce lung dose by relaxing the constraint of target dose homogeneity during treatment planning of IMRT. Ten NSCLC patients with lung tumor on the right side were selected. The total dose for planning target volume (PTV) was 60 Gy (2 Gy/fraction). For each patient, two IMRT plans with six beams were created in Pinnacle treatment planning system...
October 11, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29017827/subjective-global-assessment-sga-score-could-be-a-predictive-factor-for-radiation-pneumonitis-in-lung-cancer-patients-with-normal-pulmonary-function-treated-by-intensity-modulated-radiation-therapy-and-concurrent-chemotherapy
#12
Li Ma, WenFeng Ye, QiWen Li, Bin Wang, GuangYu Luo, ZhaoLin Chen, SuPing Guo, Bo Qiu, Hui Liu
INTRODUCTION: To investigate the relationship between malnutrition and the severity of radiation pneumonitis (RP) in patients with lung cancer with normal baseline pulmonary function and lungs' V20 < 35% treated by intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy. MATERIALS AND METHODS: A total of 150 patients with lung cancer who received definitive IMRT (≥ 60 Gy) and concurrent chemotherapy were enrolled. In the condition of normal baseline pulmonary function and strict constraints of the irradiation dose to normal lung tissues, we recorded Eastern Cooperative Oncology Group score; concurrent chemotherapy; clinical stage; the level of albumin (ALB), hemoglobin, and C-reactive protein; Subjective Global Assessment (SGA) scores; radiation esophagitis grade; V20 of lungs; and mean lung dose...
September 19, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28992206/dose-escalation-via-brachytherapy-boost-for-nasopharyngeal-carcinoma-in-the-era-of-intensity-modulated-radiation-therapy-and-combined-chemotherapy
#13
Hsing-Lung Chao, Shao-Cheng Liu, Chih-Cheng Tsao, Kuen-Tze Lin, Steve P Lee, Cheng-Hsiang Lo, Wen-Yen Huang, Ming-Yueh Liu, Yee-Min Jen, Chun-Shu Lin
To investigate if dose escalation using intracavitary brachytherapy (ICBT) improves local control for nasopharyngeal carcinoma (NPC) in the era of intensity-modulated radiation therapy (IMRT) and concurrent chemoradiation treatment (CCRT). We retrospectively analyzed 232 patients with Stage T1-3 N0-3 M0 NPC who underwent definitive IMRT with or without additional ICBT boost between 2002 and 2013. For most of the 124 patients who had ICBT boost, the additional brachytherapy was given as 6 Gy in 2 fractions completed within 1 week after IMRT of 70 Gy...
July 7, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28988893/radiation-therapy-of-synchronous-bilateral-breast-carcinoma-sbbc-using-multiple-techniques
#14
Sung Jin Kim, Mi Jo Lee, Seon Min Youn
The purpose of this study was to establish intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) treatment plans for synchronous bilateral breast cancer (SBBC) and to compare those plans with the previous treatment plans using 3D conformal radiation therapy (3DCRT). The differences among the treatments were also statistically compared regarding dosimetry distribution and treatment efficiency. The research was conducted with 10 SBBC patients. The study established IMRT (12 fields with a single isocenter) and VMAT (2 partial arcs with a single isocenter) treatment plans for SBBC patients and then compared those plans with 3DCRT (8 fields with multiple isocenters)...
October 5, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28985953/effects-of-biodegradable-hydrogel-spacer-injection-on-contralateral-submandibular-gland-sparing-in-radiotherapy-for-head-and-neck-cancers
#15
Avani D Rao, Stephanie Coquia, Robert De Jong, Christine Gourin, Brandi Page, Diane Latronico, Samson Dah, Lin Su, Stephen Clarke, Jeffrey Schultz, Lauren M Rosati, Carole Fakhry, John Wong, Theodore L DeWeese, Harry Quon, Kai Ding, Ana Kiess
Xerostomia is the most common late toxicity after head and neck radiation. We demonstrate injection of a hydrogel spacer anteriorly displacing the submandibular gland. This procedure enables reduced dose to the displaced submandibular gland in cadaveric models of oropharynx cancer treated with IMRT, with potential implications in reducing xerostomia risk.
October 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28984841/can-intensity-modulated-radiotherapy-reduce-toxicity-in-head-and-neck-squamous-cell-carcinoma
#16
REVIEW
Julie van der Veen, Sandra Nuyts
Intensity modulated radiotherapy (IMRT) is a modern radiotherapy technique that was implemented in the mid-1990s. It allows closer shaping of dose, to target volumes, thereby sparing organs at risk (OARs). Before the IMRT-era, two-dimensional radiotherapy (2DRT) and later three-dimensional conformal radiotherapy (3DCRT) were the techniques of choice, but this robust way of irradiating caused more normal tissue to receive a higher dose. Radiation of cancers in the head and neck region is complex because of close proximity to critical normal tissue and the large target volumes that need to be treated at high doses...
October 6, 2017: Cancers
https://www.readbyqxmd.com/read/28984752/intensity-modulated-radiation-therapy-for-patients-with-1-to-3-brain-metastases-in-recursive-partitioning-analysis-class-3
#17
Jia Yang, Wenming Zhan, Haibo Zhang, Tao Song, Yongshi Jia, Hongen Xu, Baihua Lin, Shiliang Lv, Xiaodong Liang
The prognosis is extremely poor for patients with brain metastases in recursive partitioning analysis (RPA) class 3. It is not clear whether dose elevation for brain lesions in addition to whole-brain radiotherapy could improve survival for those patients. This study aimed to assess the efficacy and safety of dose elevation with intensity-modulated radiation therapy (IMRT) for patients with 1 to 3 brain metastases in RPA class 3.From January 2013 to December 2015, 24 patients with 1 to 3 brain metastases in RPA class 3 were included in this study...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28984517/intermediate-risk-meningioma-initial-outcomes-from-nrg-oncology-rtog-0539
#18
Leland Rogers, Peixin Zhang, Michael A Vogelbaum, Arie Perry, Lynn S Ashby, Jignesh M Modi, Anthony M Alleman, James Galvin, David Brachman, Joseph M Jenrette, John De Groot, Joseph A Bovi, Maria Werner-Wasik, Jonathan P S Knisely, Minesh P Mehta
OBJECTIVE This is the first clinical outcomes report of NRG Oncology RTOG 0539, detailing the primary endpoint, 3-year progression-free survival (PFS), compared with a predefined historical control for intermediate-risk meningioma, and secondarily evaluating overall survival (OS), local failure, and prospectively scored adverse events (AEs). METHODS NRG Oncology RTOG 0539 was a Phase II clinical trial allocating meningioma patients to 1 of 3 prognostic groups and management strategies according to WHO grade, recurrence status, and resection extent...
October 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28983664/-radiation-therapy-of-locally-advanced-prostate-cancer
#19
REVIEW
N-S Schmidt-Hegemann, M Li, C Eze, C Belka, U Ganswindt
The risk classification for localized prostate cancer is based on the groups "low", "intermediate", and "high-risk" prostate cancer. Following this established risk group definition, locally advanced prostate cancer (cT3/4N0M0) has to be classified as "high-risk" prostate cancer. Radical prostatectomy or high-dose radiotherapy, which is combined with androgen deprivation, are the only curative standard treatments for locally advanced prostate cancer. Particularly adequate radiation doses, modern radiotherapy techniques like IMRT/IGRT, as well as long-term androgen suppression are essential for an optimal treatment outcome...
October 5, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28983442/minimal-rectal-toxicity-in-the-setting-of-comorbid-crohn-s-disease-following-prostate-cancer-radiotherapy-with-a-hydrogel-rectal-spacer
#20
Raj Singh, Philip S Jackson, Mollie Blake, James Cutlip, Sanjeev Sharma
We present one of the first cases of a prostate cancer (PCa) patient with inflammatory bowel disease (IBD) treated with intensity-modulated radiotherapy (IMRT) and a hydrogel rectal spacer. A 73-year-old male with a past medical history significant for Crohn's disease (CD) and the recent diagnosis of T1cN0M0 high-risk PCa was referred for definitive radiotherapy. Given the patient's history of CD and the possible increased risk of gastrointestinal (GI) toxicity and disease exacerbation, prior to IMRT, a hydrogel spacer was placed between the prostate and the anterior rectal wall to further minimize irradiation to the rectum...
August 1, 2017: Curēus
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