keyword
MENU ▼
Read by QxMD icon Read
search

Bovine Leukemia Virus

keyword
https://www.readbyqxmd.com/read/28221870/bovine-leukemia-virus-and-mycobacterium-avium-subsp-paratuberculosis-are-not-associated-with-shiga-toxin-producing-escherichia-coli-shedding-in-cattle
#1
Cristina Venegas-Vargas, Shannon D Manning, Paul M Coussens, Jonathan A Roussey, Paul Bartlett, Daniel Grooms
Bovine leukemia virus (BLV) is a retrovirus that causes enzootic bovine leukosis in cattle, and Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne's disease in cattle. Both diseases are chronic in nature and can lead to the disruption of normal immunological or physiological processes. Cattle are the major reservoir of Shiga toxin-producing Escherichia coli (STEC), a cause of foodborne illness in humans. We tested the hypothesis that cattle infected with BLV or MAP are more likely to shed STEC...
January 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28213870/molecular-characterization-of-bovine-leukemia-virus-from-moldovan-dairy-cattle
#2
Aneta Pluta, Marzena Rola-Łuszczak, Piotr Kubiś, Svetlana Balov, Roman Moskalik, Bhudipa Choudhury, Jacek Kuźmak
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leukosis (EBL), a disease that has worldwide distribution. Whilst it has been eradicated in most of Western Europe and Scandinavia, it remains a problem in other regions, particularly Eastern Europe and South America. For this study, in 2013, 24 cattle from three farms in three regions of Moldova were screened by ELISA and nested PCR. Of these cattle, 14 which were PCR positive, and these were molecularly characterized based on the nucleotide sequence of the env gene and the deduced amino acid sequence of the encoded gp51 protein...
February 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28159666/development-of-a-recombinase-polymerase-amplification-lateral-flow-dipstick-rpa-lfd-for-the-field-diagnosis-of-caprine-arthritis-encephalitis-virus-caev-infection
#3
Po-An Tu, Jia-Shian Shiu, Shu-Hwae Lee, Victor Fei Pang, De-Chi Wang, Pei-Hwa Wang
Caprine arthritis-encephalitis (CAE) in goats is a complex disease syndrome caused by a lentivirus. This persistent viral infection results in arthritis in adult goats and encephalitis in lambs. The prognosis for the encephalitic form is normally poor, and this form of the disease has caused substantial economic losses for goat farmers. Hence, a more efficient detection platform based on recombinase polymerase amplification (RPA) and a lateral flow dipstick (LFD) was developed in the present study for detecting the proviral DNA of caprine arthritis-encephalitis virus (CAEV)...
January 31, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28025710/clinical-and-subclinical-bovine-leukemia-virus-infection-in-a-dairy-cattle-herd-in-zambia
#4
Girja S Pandey, Edgar Simulundu, Danstan Mwiinga, Kenny L Samui, Aaron S Mweene, Masahiro Kajihara, Alfred Mangani, Racheal Mwenda, Joseph Ndebe, Satoru Konnai, Ayato Takada
Bovine leukemia virus (BLV) causes enzootic bovine leucosis (EBL) and is responsible for substantial economic losses in cattle globally. However, information in Africa on the disease is limited. Here, based on clinical, hematological, pathological and molecular analyses, two clinical cases of EBL were confirmed in a dairy cattle herd in Zambia. In contrast, proviral DNA was detected by PCR in five apparently healthy cows from the same herd, suggesting subclinical BLV infection. Phylogenetic analysis of the env gene showed that the identified BLV clustered with Eurasian genotype 4 strains...
December 26, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27938679/single-n-glycosylation-site-of-bovine-leukemia-virus-su-is-involved-in-conformation-and-viral-escape
#5
Giorgia Rizzo, Katia Forti, Anna Serroni, Monica Cagiola, Sara Baglivo, Eleonora Scoccia, Antonio De Giuseppe
The bovine leukaemia virus (BLV) envelope protein (Env) is synthesized as a polyprotein precursor (gp72) proteolytically cleaved into the mature surface (SU) and transmembrane (TM) glycoproteins. The amino-terminal region of SU contains conformational epitopes F, G and H, which require a glycosylated SU to be recognized by monoclonal antibodies (MAbs) and antibodies from BLV-infected cattle. The SU contains eight asparagine (N) residues that are putative N-glycosylation sites. The N129, N203, N230 and N251 appear involved in carbohydrate binding, play an essential role in the in vitro infection...
December 25, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27892856/co-infection-with-mycobacterium-bovis-does-not-alter-the-response-to-bovine-leukemia-virus-in-bola-drb3-0902-genetically-resistant-cattle
#6
Claudia M Lützelschwab, Agustina Forletti, Rosana Cepeda, Eduardo N Esteban, Omar Confalonieri, Silvina E Gutiérrez
High proviral load (HPL) profile in bovine leukemia virus infected animals poses increased risk of transmission, and development of HPL or low proviral load (LPL) profile may be attributed to host genetics. Genetic resistance and susceptibility has been mapped to the Major Histocompatibility Complex class II DRB3 gene (BoLA DRB3). The aim of this work was to determine the effect of Mycobacterium bovis infection on certain virological and host immunological parameters of BLV experimental infection. Twenty-six Argentinian Holstein calves carrying the resistance-associated marker allele BoLA DRB3*0902, susceptibility-associated marker allele BoLA DRB3*1501, or neutral BoLA DRB3 alleles, exposed to M...
December 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27863543/reduced-humoral-immunity-and-atypical-cell-mediated-immunity-in-response-to-vaccination-in-cows-naturally-infected-with-bovine-leukemia-virus
#7
Meredith C Frie, Kelly R Sporer, Joseph C Wallace, Roger K Maes, Lorraine M Sordillo, Paul C Bartlett, Paul M Coussens
Bovine leukemia virus (BLV) is a retrovirus that is widely distributed across US dairy herds: over 83% of herds are BLV-infected and within-herd infection rates can approach 50%. BLV infection reduces both animal longevity and milk production and can interfere with normal immune health. With such a high prevalence of BLV infection in dairy herds, it is essential to understand the circumstances by which BLV negatively affects the immune system of infected cattle. To address this question, BLV- and BLV+ adult, lactating Holstein dairy cows were vaccinated with Bovi-Shield GOLD(®) FP(®) 5 L5 HB and their immune response to vaccination was measured over the course of 28days...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27814725/whole-genome-sequencing-of-51-breast-cancers-reveals-that-tumors-are-devoid-of-bovine-leukemia-virus-dna
#8
Nicolas A Gillet, Luc Willems
Controversy exists regarding the association of bovine leukemia virus (BLV) and breast cancer. PCR-based experimental evidence indicates that BLV DNA is present in breast tissue and that as many as 37% of cancer cases may be attributable to viral exposure. Since this association might have major consequences for human health, we evaluated 51 whole genomes of breast cancer samples for the presence of BLV DNA. Among 32 billion sequencing reads retrieved from the NCBI database of genotype and phenotype, none mapped on different strains of the BLV genome...
November 4, 2016: Retrovirology
https://www.readbyqxmd.com/read/27812893/microarray-analysis-of-differential-gene-expression-profiles-in-blood-cells-of-naturally-blv-infected-and-uninfected-holstein-friesian-cows
#9
P Brym, S Kamiński
The aim of the present study was to examine gene expression changes in response to bovine leukemia virus (BLV) infection, in an effort to determine genes that take a part in molecular events leading to persistent lymphocytosis (PL), and to better define genes involved in host response to BLV infection. Using bovine 70-mer oligonucleotide spotted microarrays (BLOPlus) and qRT-PCR validation, we studied global gene expression profiles in blood cells in vivo of 12 naturally BLV-infected Polish Holstein cows, and 12 BLV non-infected controls of the same breed and reared in herds with high BLV seroprevalence...
November 3, 2016: Molecular Biology Reports
https://www.readbyqxmd.com/read/27771791/the-molecular-epidemiological-study-of-bovine-leukemia-virus-infection-in-myanmar-cattle
#10
Meripet Polat, Hla Hla Moe, Takeshi Shimogiri, Kyaw Kyaw Moe, Shin-Nosuke Takeshima, Yoko Aida
Bovine leukemia virus (BLV) is the etiological agent of enzootic bovine leukosis, which is the most common neoplastic disease of cattle. BLV infects cattle worldwide and affects both health status and productivity. However, no studies have examined the distribution of BLV in Myanmar, and the genetic characteristics of Myanmar BLV strains are unknown. Therefore, the aim of this study was to detect BLV infection in Myanmar and examine genetic variability. Blood samples were obtained from 66 cattle from different farms in four townships of the Nay Pyi Taw Union Territory of central Myanmar...
February 2017: Archives of Virology
https://www.readbyqxmd.com/read/27765074/multicentric-lymphoma-in-buffaloes-in-the-amazon-region-brazil
#11
Cairo H S De Oliveira, José D Barbosa, Karine A Damasceno, Geovanni D Cassali, Carlos Mc Oliveira, Rômulo C Leite, Jenner K P Reis
BACKGROUND: The presence of lymphoma in buffaloes was first reported in India in the 1960s. The disease is similar to Enzootic Bovine Leucosis (EBL) caused by Bovine leukemia virus (BLV) in cattle; however, according to our results and those of other studies, the etiology of these lymphomas in buffalo do not appear to be associated with BLV. The objectives of this study are to describe four cases of the disease in buffaloes belonging to the same herd in the Amazon region of Brazil and to perform a clinical-anatomopathological, immunohistochemical, and etiological study of the lymphomas...
October 20, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27748043/the-small-molecule-3g11-inhibits-hiv-1-reverse-transcription
#12
Silvana Opp, Thomas Fricke, Caitlin Shepard, Dmytro Kovalskyy, Akash Bhattacharya, Frank Herkules, Dmitri N Ivanov, Kim Baek, Jose Valle-Casuso, Felipe Diaz-Griffero
The small molecule 6-(tert-butyl)-4-phenyl-4-(trifluoromethyl)-1H,3H-1,3,5-triazin-2-one (3G11) inhibits HIV-1 replication in the human T cell line MT-2. Here we showed that 3G11 specifically and potently blocks HIV-1 infection. By contrast, 3G11 did not block other retroviruses such as HIV-2, simian immunodeficiency virus (SIVmac ), bovine immunodeficiency virus (BIV), feline immunodeficiency virus (FIV), equine infectious anemia virus (EIAV), N-tropic murine leukemia virus (N-MLV), B-tropic murine leukemia virus (B-MLV) and Moloney murine leukemia virus (Mo-MLV)...
October 17, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27725415/simple-and-rapid-method-for-routine-screening-of-bovine-leukemia-virus-by-loop-mediated-isothermal-amplification-assay
#13
Yuka Okuwa, Michiko Miyamato-Hayashi, Takaichi Tanaka, Yuji Hayakawa, Yasuo Inoshima
Various techniques for screening and detection of bovine leukemia virus (BLV) were compared to ascertain a rapid and simple technique for routine examination. The performance of real-time PCR, nested PCR and loop-mediated isothermal amplification (LAMP) assays was compared using DNA extracted from whole blood instead of white blood cells (WBCs) of 23 cattle. Real-time PCR, LAMP and nested PCR detected 18, 16 and 11 BLV-positive cattle, respectively. These results suggest that LAMP using DNA from whole blood could enable rapid examination, as isolation of WBCs and electrophoresis is time-consuming and could be useful as a simple and rapid method for routine screening of BLV...
January 20, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27725355/immune-exhaustion-during-chronic-infections-in-cattle
#14
Satoru Konnai, Shiro Murata, Kazuhiko Ohashi
Recently, dysfunction of antigen-specific T cells is well documented as T-cell exhaustion and has been defined by the loss of effector functions during chronic infections and cancer in human. The exhausted T cells are characterized phenotypically by the surface expression of immunoinhibitory receptors, such as programmed death 1 (PD-1), lymphocyte activation gene 3 (LAG-3), T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) and cytotoxic T-lymphocyte antigen 4 (CTLA-4). However, there is still a fundamental lack of knowledge about the immunoinhibitory receptors in the fields of veterinary medicine...
January 20, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27720022/lifetime-effects-of-infection-with-bovine-leukemia-virus-on-longevity-and-milk-production-of-dairy-cows
#15
Omid Nekouei, John VanLeeuwen, Henrik Stryhn, David Kelton, Greg Keefe
Enzootic bovine leukosis (EBL) is an economically important disease of dairy cattle caused by bovine leukemia virus (BLV). The economic impacts of the infection have been debated in the literature. The present study was conducted to determine the lifetime effects of BLV infection on longevity and milk production of dairy cows in Canada. The data were aggregated from a combination of two data sets: 1) BLV serum-ELISA test results from Canada-wide surveys of production limiting diseases, which took place between 1998 and 2003 in 8 provinces, and 2) longitudinal production data for all cows in the former study, extracted from the Canadian dairy herd improvement database...
October 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27545598/characterization-of-new-rna-polymerase-iii-and-rna-polymerase-ii-transcriptional-promoters-in-the-bovine-leukemia-virus-genome
#16
Benoit Van Driessche, Anthony Rodari, Nadège Delacourt, Sylvain Fauquenoy, Caroline Vanhulle, Arsène Burny, Olivier Rohr, Carine Van Lint
Bovine leukemia virus latency is a viral strategy used to escape from the host immune system and contribute to tumor development. However, a highly expressed BLV micro-RNA cluster has been reported, suggesting that the BLV silencing is not complete. Here, we demonstrate the in vivo recruitment of RNA polymerase III to the BLV miRNA cluster both in BLV-latently infected cell lines and in ovine BLV-infected primary cells, through a canonical type 2 RNAPIII promoter. Moreover, by RPC6-knockdown, we showed a direct functional link between RNAPIII transcription and BLV miRNAs expression...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27534623/inefficient-viral-replication-of-bovine-leukemia-virus-induced-by-spontaneous-deletion-mutation-in-the-g4-gene
#17
Hironobu Murakami, Jumpei Uchiyama, Sae Nikaido, Reiichiro Sato, Masahiro Sakaguchi, Kenji Tsukamoto
Enzootic bovine leucosis is caused by bovine leukemia virus (BLV) infection, which is highly prevalent in several regions of the world and significantly impacts the livestock industry. In BLV infection, the proviral load in the blood reflects disease progression. Although the BLV genome is highly conserved among retroviruses, genetic variation has been reported. However, the relationship between proviral load and genetic variation is poorly understood. In this study, we investigated the changes in proviral load in BLV-infected cattle in Japan and then identified and analysed a BLV strain pvAF967 that had a static proviral load...
October 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27475102/bovine-leukemia-virus-becomes-established-in-dairy-herds-before-the-first-lactation
#18
Ramiro Merlini, Gerónimo Gutiérrez, Irene Alvarez, Juan Pablo Jaworski, Hugo Carignano, Mario Poli, Luc Willems, Karina Trono
In this work, we studied seven groups of pregnant heifers from a consortium of dairy farms heavily infected with bovine leukemia virus (BLV). ELISA testing showed that the seroprevalence ranges of BLV in heifers between 36.1 and 66.5 %. No significant differences in proviral load were found when comparing heifers with adult cattle. Before their first delivery, more than 9.8 % of heifers show a high proviral load. Because BLV infection can occur during the first two years of life, the rationale of any strategy should be to take action as early as possible after birth...
November 2016: Archives of Virology
https://www.readbyqxmd.com/read/27473994/toll-like-receptors-ifn-%C3%AE-and-il-12-expression-in-bovine-leukemia-virus-infected-animals-with-low-or-high-proviral-load
#19
María Victoria Nieto Farias, Pamela Anahí Lendez, Maia Marin, Silvina Quintana, Lucía Martínez-Cuesta, María Carolina Ceriani, Guillermina Laura Dolcini
Bovine leukemia virus (BLV) infection is widespread mainly in dairy cattle and 5-10% of infected animals will die due to lymphosarcoma; most cattle remain asymptomatic but 30% develop persistent lymphocytosis (PL). BLV transmission depends on infected cell exchange and thus, proviral load is determinant. Understanding the mechanisms which govern the control of viral dissemination will be desirable for the design of effective therapeutic or preventive strategies for BLV. The development of high proviral load (HPL) or low proviral load (LPL) might be associated to genetic factors and humoral immune responses, however cellular responses are not fully described...
August 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27429469/diagnostic-performance-of-an-indirect-enzyme-linked-immunosorbent-assay-elisa-to-detect-bovine-leukemia-virus-antibodies-in-bulk-tank-milk-samples
#20
Omid Nekouei, Jean Durocher, Greg Keefe
This study assessed the diagnostic performance of a commercial ELISA for detecting bovine leukemia virus antibodies in bulk-tank milk samples from eastern Canada. Sensitivity and specificity of the test were estimated at 97.2% and 100%, respectively. The test was recommended as a cost-efficient tool for large-scale screening programs.
July 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
keyword
keyword
112469
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"