Naganori Nao, Tomohiro Okagawa, Naomi Nojiri, Satoru Konnai, Honami Shimakura, Misono Tominaga, Hazuka Yoshida-Furihata, Eri Nishiyama, Takahiro Matsudaira, Naoya Maekawa, Shiro Murata, Masamichi Muramatsu, Kazuhiko Ohashi, Masumichi Saito
Bovine leukemia virus (BLV) is a member of the family Retroviridae that causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3 chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from a cow with EBL. The chimeric provirus harbored a spliced SMAD3 sequence composed of exons 3-9, encoding the short isoform protein, and the BLV-SMAD3 chimeric transcript was detectable in cattle with EBL...
February 16, 2024: Archives of Virology