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Arnaud Potier, Julien Voyat, Alain Nicolas
Clonidine hydrochloride is administered to opioid-addicted mothers' neonates to reduce neonatal abstinence syndrome. It is prescribed off-label to neonates at 0.5-1 µg/kg/6 h, alone or in combination. The commercially injectable form of clonidine-Catapressan(®) 0.15 mg/mL-is being orally given after an appropriate dilution in water. However, this practice is not suitable for a perfectly safe and accurate administration. The objectives were to design a 10 µg/mL oral solution of clonidine hydrochloride in Inorpha(®) and to study the stability of this solution by a validated stability-indicating liquid chromatography (LC) method...
October 24, 2017: Pharmaceutical Development and Technology
R Serreau
During pregnancy, the maternal, placental and fetal physiological characteristics constantly evolve and thereby constantly alter drug bioavailability in the mother and feto-placental unit. Gastric emptying time is increased and bowel movements are reduced. Distribution in the maternal body is mainly influenced by body mass variations, water content and fat stores. Metabolic capacity of the liver appears unchanged but renal clearance of drugs is gradually increased. The placental transfer of most drugs mainly consists of passive diffusion between the maternal and fetal circulations, along their respective concentration gradients...
April 2010: Annales Françaises D'anesthèsie et de Rèanimation
H Niederhofer
We report about a five year-old patient suffering from tics and ADHD (attention deficit hyperkinetic disorder), aggressions, depression and emotional disorder. Furthermore, an epileptic focus and perinatal encephalopathy were diagnosed. Lofexidine (Britlofex) medication did not reduce Tic symptomatology, but showed remarkable sedative effects. Family therapy and Clonidine (Catapressan) medication reduced symptomatology significantly.
2001: Wiener Medizinische Wochenschrift
J Salat-Baroux, D Rotten, S Alvarez, J M Antoine
OBJECTIVE: To assess the reliability of growth hormone (GH) secretion tests using provocative agents in women of different ovarian status. DESIGN: Comparison of GH secretion in response to clonidine (Catapressan; Boehringer Ingelheim, Reims, France) and growth hormone-releasing factor (GH-RF). SETTING: University Hospital, Hôpital Tenon, Paris, France. PATIENTS: Women categorized as "normal" (n = 6) or "poor" responder (n = 7) to ovarian stimulation with gonadotropins, depending on the follicular development attained at previous IVF attempts...
November 1993: Fertility and Sterility
B Kåss, K Nestvold
Twenty-one patients continued a double-blind crossover study to compare the prophylactic effect on migraine of propranolol and clonidine. The daily dosage of propranolol and clonidine was 160 mg and 100 microgram, respectively. Statistical analysis did not show any significant difference between the two drugs in respect to headache or nausea. The number of sickleave days and the use of symptomatic drugs were both less on propranolol treatment than on clonidine, but there was no statistically conclusive difference...
June 1980: Acta Neurologica Scandinavica
J P Dausse, P Guicheney, P Meyer
In rat central nervous system, 3H-prazosin and 3H-clonidine bind to two different classes of alpha-adrenoceptors: - 3H-prazosin binds to alpha1-adrenoceptors with high affinity (KD 25 degrees C = 0.30 nM) with a number of binding sites of 81.6 fmoles/mg of protein. -3H-clonidine binds to alpha 2-adrenoceptors with high affinity (KD 25 degrees C - 2.1 nM) with a number of binding sites of 190.0 fmoles/mg of protein. The radioreceptor assay may help to determine rapidly in vitro the neurochemical profile of new antihypertensive compounds...
June 1981: Archives des Maladies du Coeur et des Vaisseaux
(no author information available yet)
No abstract text is available yet for this article.
February 20, 1968: Der Landarzt
M O Spach, J L Imbs, R Bloch, J Schwartz
No abstract text is available yet for this article.
January 16, 1971: La Presse Médicale
A Amery, H Bosseert, D Clement, M Deruyttere, M Verstraete
No abstract text is available yet for this article.
1970: Angiologica
A Amery, H Bossaert, M Deruyttere, G Verstreken
No abstract text is available yet for this article.
1969: Acta Clinica Belgica
M Linquette, P Fossati, J C Fourlinnie, Y M Voimant
No abstract text is available yet for this article.
February 1973: Lille Médical: Journal de la Faculté de Médecine et de Pharmacie de L'Université de Lille
J D Ehrhardt
No abstract text is available yet for this article.
September 1972: Thérapie
A V Valdman, N B Afanaseva, A Beshimov, M F Brovkov, N V Petriaevskaya, V A Tsyrlin
No abstract text is available yet for this article.
1974: Cor et Vasa
N A Lopatkin, E B Mazo, V G Goriunov, Zh T Maĭdanov
No abstract text is available yet for this article.
1974: Terapevticheskiĭ Arkhiv
D P Ivanov, N Belovezhdov, S Peneva
No abstract text is available yet for this article.
1971: Nauchni Trudove Na Visshiia Meditsinski Institut, Sofiia
F de Roquefeuil, C Goupil
No abstract text is available yet for this article.
February 1986: Soins. Cardiologie
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