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Anna Höflich, Andreas Hahn, Martin Küblböck, Georg S Kranz, Thomas Vanicek, Sebastian Ganger, Marie Spies, Christian Windischberger, Siegfried Kasper, Dietmar Winkler, Rupert Lanzenberger
Over the last years, a number of studies have been conducted to clarify the neurobiological correlates of ketamine application. However, comprehensive information regarding the influence of ketamine on cortical activity is still lacking. Using resting-state functional MRI and integrating pharmacokinetic information, a double-blind, randomized, placebo-controlled, crossover study was performed to determine the effects of ketamine on neuronal activation. During a 55 min resting-state fMRI scan, esketamine (Ketanest S® ) was administered intravenously to 35 healthy volunteers...
April 2017: Brain Structure & Function
A Prescher, C Mory, M Martin, M Fiedler, D Uhlmann
CD4+ T cells contribute to disturbances of pancreatic microcirculation after cold and even after warm ischemia/reperfusion (I/R). The aim of this study was to investigate a possible protective role of FTY720 (fingolimod) in this setting. In an in vivo model (42 Wistar rats), ischemia of the pancreas was induced for 60 minutes under anesthesia with xylazin/ketanest. Sham-operated (SO) (I), untreated ischemic (II), and treatment group with FTY720 pre-treatment (1 mg/kg body weight i.v.) (III) were investigated...
December 2010: Transplantation Proceedings
Mathias Martin, Christina Mory, Andrea Prescher, Christian Wittekind, Martin Fiedler, Dirk Uhlmann
AIM: CD4(+) T cells contribute to disturbances of liver microcirculation after warm ischemia/reperfusion (I/R). The aim of this study was to investigate a possible protective role of FTY720 (Sphingosine-1 phosphate receptor agonist) in this setting. MATERIAL AND METHODS: In an in vivo model (42 Wistar rats), ischemia of the left liver lobe was induced for 90 min under anesthesia with xylazine/ketanest. Sham-operated untreated ischemic and treatment group with FTY720 (1 mg/kg body weight intravenous) were investigated...
March 2010: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Ivan Pigarev, Helena Almirall, Marina L Pigareva, Victor Bautista, Angel Sánchez-Bahillo, Carlos Barcia, Maria Trinidad Herrero
Propagation of signals from the gastro-intestinal system towards the occipital cortex within sleep-wake cycle was investigated in three monkeys used in the study of sleep impairment in a chronic MPTP model of parkinsonism. The monkeys differed in motor abilities and sleep structure. e animal (M1) was non-motor disabled and had no sleep alterations. The other two monkeys were severely motor affected, but one (M2) had normal sleep cycles; meanwhile, the other (M3) had no complete sleep cycles. To evaluate the level of sleep and to record cortical evoked responses screw electrodes were implanted over the occipital cortex...
2006: Acta Neurobiologiae Experimentalis
Z Ileana, F Rosianu
The paper shows our experience about general anesthesia in children treated for an ophthalmologic disease in Clinic of Ophthalmology, Timişoara in the last 7 years. We think that when the globe is opened the best anesthetic is halotan and ketanest is better in closed-eye surgery and ophthalmologic examination.
1998: Oftalmologia
R E Friedrich
OBJECTIVE: To study the patency rates of anastomoses in damaged common carotid arteries in a training model of microvascular surgery (Wistar rats). MATERIAL AND METHODS: Under general anaesthesia with xylazine (Rompun) and ketamine (Ketanest) balloon dilatation was repeated five times in 31 left common carotid arteries of female Wistar rats. One minute after reflow an autograft of 4 mm was harvested, turned 180 degrees, and reinserted into the artery. The flow through the vessels was investigated by micro-Doppler ultrasound (60 s after balloon dilatation and 30 min after insertion of the autograft)...
October 1998: British Journal of Oral & Maxillofacial Surgery
C O Feddersen
No abstract text is available yet for this article.
September 1998: Der Internist
A D Krüger
Ketamine is still a relatively seldom-used anaesthetic because of its psychotomimetic and sympathomimetic side-effects and because ketamine anaesthesia is poorly controllable. At present, the enantiomer S-(+)-ketamine (Ketanest S) is clinically used. During its application, a twofold higher pharmacologic potency and a faster elimination can be expected than with the racemic-ketamine mixture. Particularly in paediatric anaesthesia, no practical experience could be gained with this new drug. Form the current standpoint, an overview is given of the possible applications of ketamine in children regarding premedication and early induction of ketamine anaesthesia in combination with midazolam because ketamine can be inserted through the nose or rectum and it can also be applied orally or intramuscularly...
1998: Anaesthesiologie und Reanimation
R Leuwer, H Maier, A W Gummer
BACKGROUND: Intraoperative measurements of local intracapillary hemoglobin oxygenation of the human cochlea via the round window membrane have been shown to be possible using the Erlangen microlight-guided spectrophotometer. The aim of the present study was to develop a new microlight guide suitable for measurements in the round window niche and to evaluate electrophysiologically the possible impact of the procedure on the cochlea. METHODS: Measurements were made for wavelengths of 450 to 900 nm at a total power of 5...
May 1997: HNO
P Senn, M Jöhr, S Kaufmann, I Schipper
BACKGROUND: Eye surgery is performed under local anesthesia in more than 90% of the cases. While injecting the local anesthetics a deep sedation is desired. During surgery however the patient should be cooperative, such as to avoid inadvertent movements. We routinely perform local anesthesia (retrobulbar injection and van Lint block) under intravenous anesthesia with propofol (Disoprivan) and ketamine (Ketalar, Ketanest). PATIENTS AND METHODS: To control safety and efficacy of this method a prospective study was performed including 100 consecutive patients...
June 1993: Klinische Monatsblätter Für Augenheilkunde
M Weiss, A Birkhahn, S Mettler, M Schneider, P Wernet
The effects of the commercially available ketamine preparation (Ketanest), the ketamine racemate and of the two enantiomers, the R(-)-racemate and the S(+)-racemate, as well as its drug-free solvent were examined by N-formyl-methionyl-leucyl-phenylalanine-(FMLP)- and zymosan-induced oxygen radical production of polymorphonuclear cells (PMN). The racemate and the two enantiomers of ketamine suppressed FMLP- and zymosan-induced chemiluminescence of PMN in a dose-dependent fashion to the same extent. Therefore suppression of chemiluminescence of PMN by ketamine does not result from a specific receptor interaction...
February 1995: Immunopharmacology and Immunotoxicology
U Hörnchen, G Tauberger
The effects of ketamine 5 mg/kg on blood pressure, heart-rate and the efferent action-potentials of the sympathetic and phrenic nerves were investigated in 17 relaxed and artificially ventilated cats. In part of the experiments (8 cats) ketamine was given as the sole narcotic agent, in the rest ketamine was applied a light basic as anaesthesia with N2O/O2 in relation of 2:1. The findings were, that ketamine given as monoanaesthetic agent increase blood pressure and heart-rate, as well as efferent sympathetic activity...
October 1980: Der Anaesthesist
B Maass, G Esser
Possible effects of extreme variations of oxygen concentration from 0% to 100% in the tympanic lumen on inner ear function were investigated through animal experiments. The experiments were performed with Ketanest anaesthetized cats under short-time acoustic irradiation (3 min 115 dB, pink noise). Inner ear function was measured by means of the stapedius reflex audiometry. On the nitrogen-flushed side (pO2 approx. 0%), the stapedius reflex threshold dropped significantly more after high-frequency irradiation than on the O2-flushed side...
March 1980: Laryngologie, Rhinologie, Otologie
R Stehle
From mid-May to mid-July 1980, 363 anaesthesias were carried out in the refugee camp Khao I Dang on the border between Thailand and Kambodia. These were done in a tropical climate under difficult conditions. The patients were refugees, mostly injured in the war. Regional anaesthesias were generally preferred as they are safer for the patients and not so much surveillance is necessary. For general anaesthesia ketamine combined with diazepam and in most cases assisted respiration by a combination of nitrogen oxide - oxygen and halothane were selected...
March 1983: Der Anaesthesist
A Lamesch, P Lamesch, V Kugener
No abstract text is available yet for this article.
1981: Zeitschrift Für Versuchstierkunde
H Lamm, E Lehnhardt, K Lamm
The round window membrane of the inner ear of the guinea pig was perforated under Ketanest anaesthesia. A very rapid and almost total loss of cochlear microphonics, auditory nerve action potential and brain-stem response developed. Replacement of the perilymph with Ringer's solution and surgical closure of the membrane damage had no effect on auditory nerve action potential or brain-stem response. Further decline in the amplitude of cochlear microphonics was halted, however. When perfusion of the round window membrane was carried out whilst the bulla was full with Ringer's solution, no essential decline was seen in the amplitudes of microphonics and auditory nerve action...
November 1984: Acta Oto-laryngologica
W Erhardt
In a review common regimens of anesthesia in the rabbit are described. To carry out an anesthesia the following knowledge is requested: preanesthetic history and physical condition, preanesthetic feeding and handling, methods of drug application (aerogen, intravenously and intramuscularly). Special anesthetic risks in the rabbit are lined out. The methods of anesthesia are presented in four tables. Long term anesthesia: Ketamine (Ketanest) + Xylazine (Rompun) i.m. or Fluanison/Fentanyl (Hypnorm) i.m. Medium term anesthesia: Ketamine + Xylazine i...
1984: Tierärztliche Praxis
D Feddersen, W Böckeler
No abstract text is available yet for this article.
January 5, 1983: DTW. Deutsche Tierärztliche Wochenschrift
H G Chüden, A Karduck
No abstract text is available yet for this article.
1970: Archiv Für Klinische und Experimentelle Ohren- Nasen- und Kehlkopfheilkunde
R Manz, H P Stegbauer, M Forster
No abstract text is available yet for this article.
December 1972: Zeitschrift Für Praktische Anästhesie, Wiederbelebung und Intensivtherapie
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