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Human connectome project

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https://www.readbyqxmd.com/read/29684644/a-gyral-coordinate-system-predictive-of-fibre-orientations
#1
Michiel Cottaar, Matteo Bastiani, Charles Chen, Krikor Dikranian, David Van Essen, Timothy E Behrens, Stamatios N Sotiropoulos, Saad Jbabdi
When axonal fibres approach or leave the cortex, their trajectories tend to closely follow the cortical convolutions. To quantify this tendency, we propose a three-dimensional coordinate system based on the gyral geometry. For every voxel in the brain, we define a "radial" axis orthogonal to nearby surfaces, a "sulcal" axis along the sulcal depth gradient that preferentially points from deep white matter to the gyral crown, and a "gyral" axis aligned with the long axis of the gyrus...
April 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29668865/association-between-brain-activation-and-functional-connectivity
#2
Dardo Tomasi, Nora D Volkow
The origin of the "resting-state" brain activity recorded with functional magnetic resonance imaging (fMRI) is still uncertain. Here we provide evidence for the neurovascular origins of the amplitude of the low-frequency fluctuations (ALFF) and the local functional connectivity density (lFCD) by comparing them with task-induced blood-oxygen level dependent (BOLD) responses, which are considered a proxy for neuronal activation. Using fMRI data for 2 different tasks (Relational and Social) collected by the Human Connectome Project in 426 healthy adults, we show that ALFF and lFCD have linear associations with the BOLD response...
April 13, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29664910/a-computational-model-of-shared-fine-scale-structure-in-the-human-connectome
#3
J Swaroop Guntupalli, Ma Feilong, James V Haxby
Variation in cortical connectivity profiles is typically modeled as having a coarse spatial scale parcellated into interconnected brain areas. We created a high-dimensional common model of the human connectome to search for fine-scale structure that is shared across brains. Projecting individual connectivity data into this new common model connectome accounts for substantially more variance in the human connectome than do previous models. This newly discovered shared structure is closely related to fine-scale distinctions in representations of information...
April 17, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29615790/multivariate-granger-causality-unveils-directed-parietal-to-prefrontal-cortex-connectivity-during-task-free-mri
#4
Andrea Duggento, Luca Passamonti, Gaetano Valenza, Riccardo Barbieri, Maria Guerrisi, Nicola Toschi
While a large body of research has focused on the study of functional brain "connectivity", few investigators have focused on directionality of brain-brain interactions which, in spite of the mostly bidirectional anatomical substrates, cannot be assumed to be symmetrical. We employ a multivariate Granger Causality-based approach to estimating directed in-network interactions and quantify its advantages using extensive realistic synthetic BOLD data simulations to match Human Connectome Project (HCP) data specification...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29603381/high-resolution-whole-brain-diffusion-mri-at-7t-using-radiofrequency-parallel-transmission
#5
Xiaoping Wu, Edward J Auerbach, An T Vu, Steen Moeller, Christophe Lenglet, Sebastian Schmitter, Pierre-François Van de Moortele, Essa Yacoub, Kâmil Uğurbil
PURPOSE: Investigating the utility of RF parallel transmission (pTx) for Human Connectome Project (HCP)-style whole-brain diffusion MRI (dMRI) data at 7 Tesla (7T). METHODS: Healthy subjects were scanned in pTx and single-transmit (1Tx) modes. Multiband (MB), single-spoke pTx pulses were designed to image sagittal slices. HCP-style dMRI data (i.e., 1.05-mm resolutions, MB2, b-values = 1000/2000 s/mm2 , 286 images and 40-min scan) and data with higher accelerations (MB3 and MB4) were acquired with pTx...
March 30, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29578031/the-unc-umn-baby-connectome-project-bcp-an-overview-of-the-study-design-and-protocol-development
#6
REVIEW
Brittany R Howell, Martin A Styner, Wei Gao, Pew-Thian Yap, Li Wang, Kristine Baluyot, Essa Yacoub, Geng Chen, Taylor Potts, Andrew Salzwedel, Gang Li, John H Gilmore, Joseph Piven, J Keith Smith, Dinggang Shen, Kamil Ugurbil, Hongtu Zhu, Weili Lin, Jed T Elison
The human brain undergoes extensive and dynamic growth during the first years of life. The UNC/UMN Baby Connectome Project (BCP), one of the Lifespan Connectome Projects funded by NIH, is an ongoing study jointly conducted by investigators at the University of North Carolina at Chapel Hill and the University of Minnesota. The primary objective of the BCP is to characterize brain and behavioral development in typically developing infants across the first 5 years of life. The ultimate goals are to chart emerging patterns of structural and functional connectivity during this period, map brain-behavior associations, and establish a foundation from which to further explore trajectories of health and disease...
March 22, 2018: NeuroImage
https://www.readbyqxmd.com/read/29571714/the-chaotic-morphology-of-the-left-superior-temporal-sulcus-is-genetically-constrained
#7
Yann Le Guen, François Leroy, Guillaume Auzias, Denis Riviere, Antoine Grigis, Jean-François Mangin, Olivier Coulon, Ghislaine Dehaene-Lambertz, Vincent Frouin
The asymmetry of the superior temporal sulcus (STS) has been identified as a species-specific feature of the human brain. The so-called superior temporal asymmetrical pit (STAP) area is observed from the last trimester of gestation onwards and is far less pronounced in the chimpanzee brain. This asymmetry is associated with more frequent sulcal interruptions, named plis de passage (PPs), leading to the irregular morphology of the left sulcus. In this paper, we aimed to characterize the variability, asymmetry, and heritability of these interruptions in the STS in comparison with the other main sulci...
March 20, 2018: NeuroImage
https://www.readbyqxmd.com/read/29571075/elevated-body-mass-index-is-associated-with-reduced-white-matter-integrity-in-two-large-independent-cohorts
#8
Jonathan Repple, Nils Opel, Susanne Meinert, Ronny Redlich, Tim Hahn, Nils R Winter, Claas Kaehler, Daniel Emden, Ramona Leenings, Dominik Grotegerd, Dario Zaremba, Christian Bürger, Katharina Förster, Katharina Dohm, Verena Enneking, Elisabeth J Leehr, Joscha Böhnlein, Greta Karliczek, Walter Heindel, Harald Kugel, Jochen Bauer, Volker Arolt, Udo Dannlowski
Obesity has been associated with a variety of neurobiological alterations. Recent neuroimaging research has pointed to the relevance of brain structural and functional alterations in the development of obesity. However, while the role of gray matter atrophy in obesity has been evidenced in several well powered studies, large scale evidence for altered white matter integrity in obese subjects is still absent. With this study, we therefore aimed to investigate potential associations between white matter abnormalities and body mass index (BMI) in two large independent samples of healthy adults...
March 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29568689/both-activated-and-less-activated-regions-identified-by-functional-mri-reconfigure-to-support-task-executions
#9
Nianming Zuo, Zhengyi Yang, Yong Liu, Jin Li, Tianzi Jiang
Introduction: Functional magnetic resonance imaging (fMRI) has become very important for noninvasively characterizing BOLD signal fluctuations, which reflect the changes in neuronal firings in the brain. Unlike the activation detection strategy utilized with fMRI, which only emphasizes the synchronicity between the functional nodes (activated regions) and the task design, brain connectivity and network theory are able to decipher the interactive structure across the entire brain. However, little is known about whether and how the activated/less-activated interactions are associated with the functional changes that occur when the brain changes from the resting state to a task state...
January 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29551458/distinct-functional-and-structural-neural-underpinnings-of-working-memory
#10
Max M Owens, Bryant Duda, Lawrence H Sweet, James MacKillop
Working memory (WM), the short-term abstraction and manipulation of information, is an essential neurocognitive process in daily functioning. Few studies have concurrently examined the functional and structural neural correlates of WM and the current study did so to characterize both overlapping and unique associations. Participants were a large sample of adults from the Human Connectome Project (N = 1064; 54% female) who completed an in-scanner visual N-back WM task. The results indicate a clear dissociation between BOLD activation during the WM task and brain structure in relation to performance...
March 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29550369/asymmetric-orientation-distribution-functions-aodfs-revealing-intravoxel-geometry-in-diffusion-mri
#11
Suheyla Cetin Karayumak, Evren Özarslan, Gozde Unal
Characterization of anisotropy via diffusion MRI reveals fiber crossings in a substantial portion of voxels within the white-matter (WM) regions of the human brain. A considerable number of such voxels could exhibit asymmetric features such as bends and junctions. However, widely employed reconstruction methods yield symmetric Orientation Distribution Functions (ODFs) even when the underlying geometry is asymmetric. In this paper, we employ inter-voxel directional filtering approaches through a cone model to reveal more information regarding the cytoarchitectural organization within the voxel...
March 14, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29549369/an-anova-approach-for-statistical-comparisons-of-brain-networks
#12
Daniel Fraiman, Ricardo Fraiman
The study of brain networks has developed extensively over the last couple of decades. By contrast, techniques for the statistical analysis of these networks are less developed. In this paper, we focus on the statistical comparison of brain networks in a nonparametric framework and discuss the associated detection and identification problems. We tested network differences between groups with an analysis of variance (ANOVA) test we developed specifically for networks. We also propose and analyse the behaviour of a new statistical procedure designed to identify different subnetworks...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29549287/function-specific-and-enhanced-brain-structural-connectivity-mapping-via-joint-modeling-of-diffusion-and-functional-mri
#13
Shu-Hsien Chu, Keshab K Parhi, Christophe Lenglet
A joint structural-functional brain network model is presented, which enables the discovery of function-specific brain circuits, and recovers structural connections that are under-estimated by diffusion MRI (dMRI). Incorporating information from functional MRI (fMRI) into diffusion MRI to estimate brain circuits is a challenging task. Usually, seed regions for tractography are selected from fMRI activation maps to extract the white matter pathways of interest. The proposed method jointly analyzes whole brain dMRI and fMRI data, allowing the estimation of complete function-specific structural networks instead of interactively investigating the connectivity of individual cortical/sub-cortical areas...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29541539/the-crossed-frontal-aslant-tract-a-possible-pathway-involved-in-the-recovery-of-supplementary-motor-area-syndrome
#14
Cordell M Baker, Joshua D Burks, Robert G Briggs, Adam D Smitherman, Chad A Glenn, Andrew K Conner, Dee H Wu, Michael E Sughrue
Introduction: Supplementary motor area (SMA) syndrome is a constellation of temporary symptoms that may occur following tumors of the frontal lobe. Affected patients develop akinesia and mutism but often recover within weeks to months. With our own case examples and with correlations to fiber tracking validated by gross anatomical dissection as ground truth, we describe a white matter pathway through which recovery may occur. Methods: Diffusion spectrum imaging from the Human Connectome Project was used for tractography analysis...
March 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29524622/disclosing-large-scale-directed-functional-connections-in-meg-with-the-multivariate-phase-slope-index
#15
Alessio Basti, Vittorio Pizzella, Federico Chella, Gian Luca Romani, Guido Nolte, Laura Marzetti
The phase slope index (PSI) is a method to disclose the direction of frequency-specific neural interactions from magnetoencephalographic (MEG) time series. A fundamental property of PSI is that of vanishing for linear mixing of independent neural sources. This property allows PSI to cope with the artificial instantaneous connectivity among MEG sensors or brain sources induced by the field spread. Nevertheless, PSI is limited by being a bivariate estimator of directionality as opposite to the multidimensional nature of brain activity as revealed by MEG...
March 7, 2018: NeuroImage
https://www.readbyqxmd.com/read/29523000/neighborhood-resolved-fiber-orientation-distributions-nrfod-in-automatic-labeling-of-white-matter-fiber-pathways
#16
Devran Ugurlu, Zeynep Firat, Uğur Türe, Gozde Unal
Accurate digital representation of major white matter bundles in the brain is an important goal in neuroscience image computing since the representations can be used for surgical planning, intra-patient longitudinal analysis and inter-subject population connectivity studies. Reconstructing desired fiber bundles generally involves manual selection of regions of interest by an expert, which is subject to user bias and fatigue, hence an automation is desirable. To that end, we first present a novel anatomical representation based on Neighborhood Resolved Fiber Orientation Distributions (NRFOD) along the fibers...
February 27, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29503515/riccati-regularized-precision-matrices-for-neuroimaging
#17
Nicolas Honnorat, Christos Davatzikos
The introduction of graph theory in neuroimaging has provided invaluable tools for the study of brain connectivity. These methods require the definition of a graph, which is typically derived by estimating the effective connectivity between brain regions through the optimization of an ill-posed inverse problem. Considerable efforts have been devoted to the development of methods extracting sparse connectivity graphs. The present paper aims at highlighting the benefits of an alternative approach. We investigate low-rank L2 regularized matrices recently introduced under the denomination of Riccati regularized precision matrices...
June 2017: Information Processing in Medical Imaging: Proceedings of the ... Conference
https://www.readbyqxmd.com/read/29496609/the-dorsal-striatum-and-the-dynamics-of-the-consensus-connectomes-in-the-frontal-lobe-of-the-human-brain
#18
Csaba Kerepesi, Bálint Varga, Balázs Szalkai, Vince Grolmusz
In the applications of the graph theory, it is unusual that one considers numerous, pairwise different graphs on the very same set of vertices. In the case of human braingraphs or connectomes, however, this is the standard situation: the nodes correspond to anatomically identified cerebral regions, and two vertices are connected by an edge if a diffusion MRI-based workflow identifies a fiber of axons, running between the two regions, corresponding to the two vertices. Therefore, if we examine the braingraphs of n subjects, then we have n graphs on the very same, anatomically identified vertex set...
February 26, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29486870/subcortical-local-functional-hyperconnectivity-in-cannabis-dependence
#19
Peter Manza, Dardo Tomasi, Nora D Volkow
BACKGROUND: Cannabis abuse (CA) has been associated with psychopathology, including negative emotionality and higher risk of psychosis, particularly with early age of initiation. However, the mechanisms underlying this association are poorly understood. Because aberrant dopamine signaling is implicated in cannabis-associated psychopathology, we hypothesized that regular CA would be associated with altered resting-state functional connectivity in dopamine midbrain-striatal circuits. METHODS: We examined resting-state brain activity of subcortical regions in 441 young adults from the Human Connectome Project, including 30 subjects with CA meeting DSM-IV criteria for dependence and 30 control subjects matched on age, sex, education, body mass index, anxiety, depression, and alcohol and tobacco usage...
March 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29477586/evidence-for-association-between-familial-bipolar-risk-and-ventral-striatal-volume
#20
T M Lancaster
BACKGROUND: Recent genome-wide association studies (GWAS) of striatal volumes and bipolar disorder (BD) indicate these traits are heritable and share common genetic architecture, however little independent work has been conducted to help establish this relationship. METHODS: Subcortical volumes (mm3 ) of young, healthy offspring of BD (N= 32) and major depressive disorder (MDD) patients (N= 158) were compared to larger healthy control sample (NRANGE = 925-1052) adjusting for potential confounds, using data from the latest release (S1200) of the Human Connectome Project...
February 17, 2018: Journal of Affective Disorders
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