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Hypoxia Imaging

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https://www.readbyqxmd.com/read/29333924/dynamic-mr-imaging-for-functional-vascularization-depends-on-tissue-factor-signaling-in-glioblastoma
#1
Xiao Chen, Tian Xie, Jingqin Fang, Wei Xue, Houyi Kang, Haipeng Tong, Yu Guo, Bo Zhang, Sumei Wang, Yizeng Yang, Weiguo Zhang
Glomeruloid vascular proliferation (GVP) is a diagnostic hallmark and links to aggressive behavior, therapy resistance and poor prognosis in glioblastoma (GBM). It lacks clinical approaches to predict and monitor its formation and dynamic change. Yet the mechanism of GVPs also remains largely unknown. Using an in situ GBM xenograft mouse model, combined clinical MRI images of pre-surgery tumor and pathological investigation, we demonstrated that the inhibition of tissue factor (TF) decreased GVPs in Mouse GBM xenograft model...
January 15, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29331296/a-case-of-autosplenectomy-in-sickle-cell-trait-following-an-exposure-to-high-altitude
#2
Uday Yanamandra, Reena Das, Pankaj Malhotra, Subhash Varma
A 24-year-old man presented with acute abdominal pain upon ascent to moderate altitude (3500 m). An immediate evaluation revealed a splenic infarct, and he was evacuated to sea level. Upon recovery, he was sent back to 3500 m without detailed etiological evaluation, whereupon he experienced recurrent episodes of left-side subcostal pain. Imaging suggested autosplenectomy, and workup revealed a negative thrombophilia profile but was positive for sickle cell trait (SCT). Individuals with SCT can be asymptomatic until exposure to severe hypoxia, upon which they can manifest clinically as sickle cell syndrome...
January 10, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29330810/correlation-of-glioma-proliferation-and-hypoxia-by-luciferase-magnetic-resonance-and-positron-emission-tomography-imaging
#3
Michael Karsy, David L Gillespie, Kevin P Horn, Lance D Burrell, Jeffery T Yap, Randy L Jensen
Gliomas are the most common type of primary, malignant brain tumor and significantly impact patients, who have a median survival of ~1 year depending on mutational background. Novel imaging modalities such as luciferase bioluminescence, micro-magnetic resonance imaging (micro-MRI), micro-computerized tomography (micro-CT), and micro-positron emission tomography (micro-PET) have expanded the portfolio of tools available to study this disease. Hypoxia, a key oncogenic driver of glioma and mechanism of resistance, can be studied in vivo by the concomitant use of noninvasive MRI and PET imaging...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29330794/hypoxia-mediated-in-vivo-tumor-glucose-uptake-measurement-and-analysis
#4
Surendra K Shukla, Scott E Mulder, Pankaj K Singh
Most solid tumors are hypoxic in nature due to the limited supply of oxygen to internal tissues. Hypoxia plays an important role in metabolic adaptations of tumors that contribute significantly to cancer pathogenesis. Among the several metabolic alterations induced by hypoxia, hypoxia-mediated increased glucose uptake serves as the hallmark of metabolic reprogramming. Hypoxia-mediated stabilization of hypoxia-inducible factor-1 alpha (HIF-1α) transcription factor leads to altered expression of several glycolytic genes and glucose transporters, which results in increased glucose uptake by tumor cells...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29330789/fluorescence-lifetime-imaging-microscopy-flim-as-a-tool-to-investigate-hypoxia-induced-protein-protein-interaction-in-living-cells
#5
Vera Schützhold, Joachim Fandrey, Katrin Prost-Fingerle
Fluorescence resonance energy transfer (FRET) is widely used as a method to investigate protein-protein interactions in living cells. A FRET pair donor fluorophore in close proximity to an appropriate acceptor fluorophore transfers emission energy to the acceptor, resulting in a shorter lifetime of the donor fluorescence. When the respective FRET donor and acceptor are fused with two proteins of interest, a reduction in donor lifetime, as detected by fluorescence lifetime imaging microscopy (FLIM), can be taken as proof of close proximity between the fluorophores and therefore interaction between the proteins of interest...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29329462/silibinin-from-silybum-marianum-stimulates-embryonic-stem-cell-vascular-differentiation-via-the-stat3-pi3-k-akt-axis-and-nitric-oxide
#6
Enas Hussein Ali, Fatemeh Sharifpanah, Maria Wartenberg, Heinrich Sauer
Silibinin, the bioactive compound of milk thistle (Silybum marianum), exerts tissue protective and regenerative effects that may include stem cell differentiation toward vascular cells. The purpose of the present study was to investigate whether silibinin stimulates blood vessel formation from mouse embryonic stem (ES) cells and to unravel the underlying signaling cascade. Vascular branching points were assessed by confocal laser scanning microscopy and computer-assisted image analysis of CD31-positive cell structures...
January 12, 2018: Planta Medica
https://www.readbyqxmd.com/read/29326160/hypoxia-inducible-lipid-droplet-associated-protein-inhibits-adipose-triglyceride-lipase
#7
Krishna M Padmanabha Das, Lisa Wechselberger, Márton Liziczai, Montserrat De la Rosa Rodriguez, Gernot F Grabner, Christoph Heier, Roland Viertlmayr, Claudia Radler, Joerg Lichtenegger, Robert Zimmermann, Jan Willem Borst, Rudolf Zechner, Sander Kersten, Monika Oberer
Elaborate control mechanisms of intracellular triacylglycerol (TAG) breakdown are critically involved in the maintenance of energy homeostasis. Hypoxia inducible lipid droplet associated protein (HILPDA)/Hypoxia inducible gene-2 (Hig-2) has been shown to affect intracellular TAG levels, yet, the underlying molecular mechanisms are unclear. Here, we show that HILPDA inhibits adipose triglyceride lipase (ATGL), the enzyme catalyzing the first step of intracellular TAG hydrolysis. HILPDA shares structural similarity with G0/G1 switch gene 2 (G0S2), an established inhibitor of ATGL...
January 11, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29325997/reduced-cortical-oxygenation-predicts-a-progressive-decline-of-renal-function-in-patients-with-chronic-kidney-disease
#8
Menno Pruijm, Bastien Milani, Edward Pivin, Agata Podhajska, Bruno Vogt, Matthias Stuber, Michel Burnier
Renal tissue hypoxia is a final pathway in the development and progression of chronic kidney disease (CKD), but whether renal oxygenation predicts renal function decline in humans has not been proven. Therefore, we performed a prospective study and measured renal tissue oxygenation by blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in 112 patients with CKD, 47 with hypertension without CKD, and 24 healthy control individuals. Images were analyzed with the twelve-layer concentric objects method that divided the renal parenchyma in 12 layers of equal thickness and reports the mean R2* value of each layer (a high R2* corresponds to low oxygenation), along with the change in R2* between layers called the R2* slope...
January 9, 2018: Kidney International
https://www.readbyqxmd.com/read/29315957/apparent-diffusion-coefficients-in-prostate-cancer-correlation-with-molecular-markers-ki-67-hif-1%C3%AE-and-vegf
#9
Teng Ma, Shaolin Yang, Haiyan Jing, Lin Cong, Zhixin Cao, Zhiling Liu, Zhaoqin Huang
Prostate cancer (PCa) is the second most common cancer in men. The Gleason score (GS) and biomarkers play important roles in the diagnosis and treatment of patients with PCa. The purpose of this study was to investigate the relationship between the apparent diffusion coefficient (ADC) and the molecular markers Ki-67, hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in PCa. Thirty-nine patients with 39 lesions, who had been diagnosed with PCa, were enrolled in this study. All patients underwent diffusion-weighted magnetic resonance imaging (DW-MRI) (b = 800 s/mm2 )...
January 9, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29313656/pl-w18o49-tpz-nanoparticles-for-simultaneous-hypoxia-activated-chemotherapy-and-photothermal-therapy
#10
Peichen Zhao, Shuangshuang Ren, Yumei Liu, Wei Huang, Chao Zhang, Jian He
The combination of W18O49 and TPZ core has been first introduced into the preparation of PEG-PCL (PL) surrounded nanoparticles (NPs). The aim of using W18O49 is employing its capability of reacting with the absorbed O2 to generate reactive oxygen species (ROS) when exposed to a long wavelength laser at 808 nm to increase skin penetration and body tolerance. In this work, we have demonstrated that W18O49 unit gives rise to more hypoxic tumor microenvironment and activate the prodrug TPZ to achieve hypoxia-activated chemotherapy, which could be monitored by the intracellular ROS/hypoxia detection and in vivo PET imaging...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29312585/increased-risk-of-brain-cancer-incidence-in-stroke-patients-a-clinical-case-series-population-based-and-longitudinal-follow-up-study
#11
Chih-Wei Chen, Tain-Junn Cheng, Chung-Han Ho, Jhi-Joung Wang, Shih-Feng Weng, Ya-Chin Hou, Hung-Chi Cheng, Chung-Ching Chio, Yan-Shen Shan, Wen-Tsan Chang
Stroke and brain cancer are two distinct diseases. However, the relationship between both diseases has rarely been examined. This study investigated the longitudinal risk for developing brain cancer in stroke patients. To study this, we first reviewed the malignant gliomas previously with or without stroke using brain magnetic resonance imaging (MRI) images and the past histories. Two ischemic stroke patients before the malignant glioma were identified and belonged to the glioblastoma mutiforme (GBM). Particularly, both GBM specimens displayed strong hypoxia-inducible factor 1α (HIF-1α) expression in immunohistochemical (IHC) staining...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311558/radiogenomic-analysis-of-hypoxia-pathway-is-predictive-of-overall-survival-in-glioblastoma
#12
Niha Beig, Jay Patel, Prateek Prasanna, Virginia Hill, Amit Gupta, Ramon Correa, Kaustav Bera, Salendra Singh, Sasan Partovi, Vinay Varadan, Manmeet Ahluwalia, Anant Madabhushi, Pallavi Tiwari
Hypoxia, a characteristic trait of Glioblastoma (GBM), is known to cause resistance to chemo-radiation treatment and is linked with poor survival. There is hence an urgent need to non-invasively characterize tumor hypoxia to improve GBM management. We hypothesized that (a) radiomic texture descriptors can capture tumor heterogeneity manifested as a result of molecular variations in tumor hypoxia, on routine treatment naïve MRI, and (b) these imaging based texture surrogate markers of hypoxia can discriminate GBM patients as short-term (STS), mid-term (MTS), and long-term survivors (LTS)...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29307364/brain-metastases-neuroimaging
#13
Whitney B Pope
Magnetic resonance imaging (MRI) is the cornerstone for evaluating patients with brain masses such as primary and metastatic tumors. Important challenges in effectively detecting and diagnosing brain metastases and in accurately characterizing their subsequent response to treatment remain. These difficulties include discriminating metastases from potential mimics such as primary brain tumors and infection, detecting small metastases, and differentiating treatment response from tumor recurrence and progression...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29302671/tailoring-the-properties-of-a-hypoxia-responsive-1-8-naphthalimide-for-imaging-applications
#14
Kylie Yang, Kathryn G Leslie, Sally Y Kim, Bill Kalionis, Wojciech Chrzanowski, Katrina A Jolliffe, Elizabeth J New
Sensing hypoxia in tissues and cell models can provide insights into its role in disease states and cell development. Fluorescence imaging is a minimally-invasive method of visualising hypoxia in many biological systems. Here we present a series of improved bioreductive fluorescent sensors based on a nitro-naphthalimide structure, in which selectivity, photophysical properties, toxicity and cellular uptake are tuned through structural modifications. This new range of compounds provides improved probes for imaging and monitoring hypoxia, customised for a range of different applications...
January 5, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29291163/oxygen-self-sufficient-amphiphilic-polypeptide-nanoparticles-encapsulating-bodipy-for-potential-near-infrared-imaging-guided-photodynamic-therapy-at-low-energy
#15
Le Liu, Zheng Ruan, Pan Yuan, Tuanwei Li, Lifeng Yan
Near infrared (NIR) imaging-guided photodynamic therapy (PDT) is remarkable for its high-efficiency in "see and treat" field. However, hypoxia of cancer cell limits PDT dues to the low singlet oxygen yield. Here MnO2 conjugated multifunctional polypeptide nanoparticles encapsulating photosensitizer BODIPY has been prepared via a one-step reaction, which can generate oxygen in cancer cytoplasm where rich of H2O2, following singlet oxygen by photosensitizer under NIR light irradiation. In vitro studies on HepG2 and 4T1 cancer cells revealed that the as-prepared nanoparticles obviously increase the cell suppression rate under hypoxia conditions, even exposed to an extremely low light energy density (25 mW/cm2)...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29289482/the-correlation-between-hif-1-alpha-and-vegf-in-oral-squamous-cell-carcinomas-expression-patterns-and-quantitative-immunohistochemical-analysis
#16
Li-Tzu Lee, Yong-Kie Wong, Chan Man-Yee, Kuo-Wei Chang, Shyh-Chang Chen, Chiou-Tuz Chang, John Wang
BACKGROUND: The prognostic predict biomarkers are important in oral squamous cell carcinoma (OSCC). We investigated the expression patterns and quantitation of hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in OSCC patients. Among OSCC patients with recurrence and metastasis, the expression percentages of HIF-1α and VEGF also were analyzed. METHODS: Thirty-eight patients (8 hyperkeratosis, 30 oral squamous cell carcinoma) were included in this study...
December 27, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29288070/neonatal-erythropoietin-mitigates-impaired-gait-social-interaction-and-diffusion-tensor-imaging-abnormalities-in-a-rat-model-of-prenatal-brain-injury
#17
Shenandoah Robinson, Christopher J Corbett, Jesse L Winer, Lindsay A S Chan, Jessie R Maxwell, Christopher V Anstine, Tracylyn R Yellowhair, Nicholas A Andrews, Yirong Yang, Laurel O Sillerud, Lauren L Jantzie
Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these children. Moreover, the mechanisms of perinatal brain injury that result in functional deficits and imaging abnormalities in the mature brain are poorly defined, limiting the potential to target interventions to those who may benefit most...
December 26, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29286442/neurobehavioral-assessments-in-a-mouse-model-of-neonatal-hypoxic-ischemic-brain-injury
#18
MinGi Kim, Ji Hea Yu, Jung Hwa Seo, Yoon-Kyum Shin, Soohyun Wi, Ahreum Baek, Suk-Young Song, Sung-Rae Cho
We performed unilateral carotid artery occlusion on CD-1 mice to create a neonatal hypoxic-ischemic (HI) model and investigated the effects of neonatal HI brain injury by studying neurobehavioral functions in these mice compared to non-operated (i.e., normal) mice. During the study, Rice-Vannucci's method was used to induce neonatal HI brain damage in postnatal day 7-10 (P7-10) mice. The HI operation was performed on the pups by unilateral carotid artery ligation and exposure to hypoxia (8% O2 and 92% N2 for 90 min)...
November 24, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29284035/effects-on-schooling-function-in-mackerel-of-sub-lethal-capture-related-stressors-crowding-and-hypoxia
#19
Nils Olav Handegard, Maria Tenningen, Kirsten Howarth, Neil Anders, Guillaume Rieucau, Michael Breen
The selectivity of fishing gears with respect to fish species and size is important, both for fisheries management and fishing operations. Purse seining is an efficient, environmentally friendly fish capture methodology generally targeting single species aggregations, but once a fish school has been selected and surrounded by the seine, there is no selections for individual size, species or catch quantity. A common practice for evaluating the catch is to haul the seine to a point where physical samples or inspections of catch composition can be made...
2017: PloS One
https://www.readbyqxmd.com/read/29275475/imaging-the-tumor-microenvironment
#20
Marie-Caline Z Abadjian, W Barry Edwards, Carolyn J Anderson
The tumor microenvironment consists of tumor, stromal, and immune cells, as well as extracellular milieu. Changes in numbers of these cell types and their environments have an impact on cancer growth and metastasis. Non-invasive imaging of aspects of the tumor microenvironment can provide important information on the aggressiveness of the cancer, whether or not it is metastatic, and can also help to determine early response to treatment. This chapter provides an overview on non-invasive in vivo imaging in humans and mouse models of various cell types and physiological parameters that are unique to the tumor microenvironment...
2017: Advances in Experimental Medicine and Biology
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