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Hypoxia Imaging

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https://www.readbyqxmd.com/read/28632821/encapsulated-islet-transplantation-where-do-we-stand
#1
Vijayaganapathy Vaithilingam, Sumeet Bal, Bernard E Tuch
Transplantation of pancreatic islets encapsulated within immuno-protective microcapsules is a strategy that has the potential to overcome graft rejection without the need for toxic immunosuppressive medication. However, despite promising preclinical studies, clinical trials using encapsulated islets have lacked long-term efficacy, and although generally considered clinically safe, have not been encouraging overall. One of the major factors limiting the long-term function of encapsulated islets is the host's immunological reaction to the transplanted graft which is often manifested as pericapsular fibrotic overgrowth (PFO)...
2017: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/28629902/relationship-between-vessel-diameter-and-depth-measurements-within-the-limbus-using-ultra-high-resolution-optical-coherence-tomography
#2
Emmanuel Alabi, Natalie Hutchings, Kostadinka Bizheva, Trefford Simpson
PURPOSE: To establish a relationship between the diameter and depth position of vessels in the superior and inferior corneo-scleral limbus using ultra-high resolution optical coherence tomography (UHR-OCT). METHODS: Volumetric OCT images of the superior and inferior limbus were acquired from 14 healthy subjects with a research-grade UHR-OCT system. Differences in vessel diameter and depth between superior and inferior limbus were analyzed using repeated measured ANOVA in SPSS and R...
June 16, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28627960/lack-of-functional-normalisation-of-tumour-vessels-following-anti-angiogenic-therapy-in-glioblastoma
#3
Nina Obad, Heidi Espedal, Radovan Jirik, Per Oystein Sakariassen, Cecilie Brekke Rygh, Morten Lund-Johansen, Torfinn Taxt, Simone P Niclou, Rolf Bjerkvig, Olivier Keunen
Neo-angiogenesis represents an important factor for the delivery of oxygen and nutrients to a growing tumour, and is considered to be one of the main pathodiagnostic features of glioblastomas (GBM). Anti-angiogenic therapy by vascular endothelial growth factor (VEGF) blocking agents has been shown to lead to morphological vascular normalisation resulting in a reduction of contrast enhancement as seen by magnetic resonance imaging (MRI). Yet the functional consequences of this normalisation and its potential for improved delivery of cytotoxic agents to the tumour are not known...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28624656/strontium-and-cobalt-substituted-bioactive-glasses-seeded-with-human-umbilical-cord-perivascular-cells-to-promote-bone-regeneration-via-enhanced-osteogenic-and-angiogenic-activities
#4
Saeid Kargozar, Nasrin Lotfibakhshaiesh, Jafar Ai, Masoud Mozafari, Peiman Brouki Milan, Sepideh Hamzehlou, Mahmoud Barati, Francesco Baino, Robert G Hill, Mohammad Taghi Joghataei
Designing and developing new biomaterials to accelerate bone healing are currently under progress. In this study, we attempted to promote osteogenesis using strontium- and cobalt- substituted bioactive glasses (BGs) seeded with human umbilical cord perivascular cells (HUCPVCs) in a critical size defect in the distal femur of rabbit animal model. The BG particles were successfully synthesized in the form of granules using the melt-derived route. After being isolated, HUCPVCs were expanded and then characterized to use during in vitro and in vivo procedures...
June 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28620866/high-levels-of-igf-1-predict-difficult-intubation-of-patients-with-acromegaly
#5
Yu Zhang, Xiaopeng Guo, Lijian Pei, Zhuhua Zhang, Gang Tan, Bing Xing
PURPOSE: To investigate the characteristics of difficult intubation and identify novel efficient predictors in patients with acromegaly. METHODS: Patients with either untreated acromegaly or non-functional pituitary adenomas were enrolled. Patients with acromegaly underwent hormone assays, upper airway computed tomography and magnetic resonance imaging examinations and preoperative overnight polysomnography. The modified Mallampati classification, mouth opening, neck circumference, and neck extension were assessed, and the Cormack-Lehane grades and the time of tracheal intubation were recorded...
June 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28619735/the-evolving-role-of-succinate-in-tumor-metabolism-an-18-f-fdg-based-study
#6
Philippe Garrigue, Aurore Bodin-Hullin, Laure Balasse, Samantha Fernandez, Wassim Essamet, Françoise Dignat-George, Karel Pacak, Benjamin Guillet, David Taieb
Objective: In recent years, inherited and acquired mutations in the TCA cycle enzymes have been reported in diverse cancers. Pheochromocytomas and paragangliomas (PPGLs) often exhibit dysregulation of glucose metabolism which is also driven by mutations in genes encoding the TCA cycle enzymes or by activation of hypoxia signaling. PPGLs associated with succinate dehydrogenase (SDH) deficiency are characterized by high (18)F-fluorodeoxyglucose ([(18)F]-FDG) avidity. This association is currently only partially explained...
June 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28619691/a-mouse-model-of-antepartum-stillbirth
#7
Anum Rahman, Lindsay S Cahill, Yu-Qing Zhou, Johnathan Hoggarth, Monique Y Rennie, Mike Seed, Christopher K Macgowan, John C Kingdom, S Lee Adamson, John G Sled
BACKGROUND: Many stillbirths of normally-formed fetuses in the third trimester could be prevented via delivery if reliable means to anticipate this outcome existed. However, since the etiology of these stillbirths is often unexplained and, although the underlying mechanism is presumed to be hypoxia from "placental insufficiency", the placentas often appear normal on histopathologic examination. Gestational age is a risk factor for antepartum stillbirth, with a rapid rise in stillbirth rates after 40 weeks gestation...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28613935/obstructive-sleep-apnea-and-subclinical-interstitial-lung-disease-in-mesa
#8
John S Kim, Anna J Podolanczuk, Priya Borker, Steven M Kawut, Ganesh Raghu, Joel D Kaufman, Karen D Hinckley Stukovsky, Eric A Hoffman, R Graham Barr, Daniel J Gottlieb, Susan S Redline, David J Lederer
RATIONALE: Obstructive sleep apnea (OSA) has been postulated to contribute to idiopathic pulmonary fibrosis by promoting alveolar epithelial injury via tractional forces and intermittent hypoxia. OBJECTIVE: To determine whether OSA is associated with subclinical interstitial lung disease (ILD) and with biomarkers of alveolar epithelial injury and remodeling. METHODS: We performed cross-sectional analyses of 1,690 community-dwelling adults who underwent 15-channel in-home polysomnography and thoracic computed tomography (CT) imaging in the Multi-Ethnic Study of Atherosclerosis...
June 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28613358/oct-angiography-assessment-of-retinal-ischemia-in-susac-s-syndrome
#9
Karina Spiess, Jesús Ramón García Martínez
Descriptive study of two patients affected by Susac's syndrome (SuS) focusing on the chronic retinal tissue damage assessed by optical coherence tomography (OCT) and OCT angiography (OCTA). To the authors' knowledge, this is the first case series reporting OCTA in SuS. OCTA imaging revealed secondary hypoxia due to branch retinal artery occlusion of the deep capillary plexus, with additional involvement of the superficial capillary network in one case. OCTA is a noninvasive and quick diagnostic tool for detecting hypoxic retinal damage in SuS...
June 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28606060/antiangiogenic-agents-targeting-different-angiogenic-pathways-have-opposite-effects-on-tumor-hypoxia-in-r-18-human-melanoma-xenografts
#10
Jon-Vidar Gaustad, Trude G Simonsen, Lise Mari K Andersen, Einar K Rofstad
BACKGROUND: Studies comparing the effect of antiangiogenic agents targeting different angiogenic pathways are sparse. The purpose of this study was to compare the effect of properdistatin and sunitinib treatment in a preclinical model of malignant melanoma. Properdistatin is a small peptide derived from the thrombospondin-1 domain of the plasma protein properdin, and sunitinib is a tyrosine kinase inhibitor targeting several receptors including the vascular endothelial growth factor receptors...
June 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28605408/casparian-bands-and-suberin-lamellae-in-exodermis-of-lateral-roots-an-important-trait-of-roots-system-response-to-abiotic-stress-factors
#11
Edita Tylová, Eva Pecková, Zuzana Blascheová, Aleš Soukup
Background and Aims: Root absorptive characteristics rely on the presence of apoplastic barriers. However, little is known about the establishment of these barriers within a complex root system, particularly in a major portion of them - the lateral roots. In Zea mays L., the exodermis differentiates under the influence of growth conditions. Therefore, the species presents a suitable model to elucidate the cross-talk among environmental conditions, branching pattern and the maturation of barriers within a complex root system involved in the definition of the plant-soil interface...
June 12, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28599305/heptamethine-carbocyanine-dz-1-dye-for-near-infrared-fluorescence-imaging-of-hepatocellular-carcinoma
#12
Jiaze An, Ningning Zhao, Caiqin Zhang, Yong Zhao, Dengxu Tan, Ya Zhao, Bing Bai, Hai Zhang, Boyang Jason Wu, Changhong Shi
Nar-infrared fluorescence (NIRF) dyes have recently emerged as promising tools for non-invasive imaging of different types of cancers. Heree, we explored the potential utility of a NIRF DZ-1 dye, with dual imaging and tumour targeting functions, in hepatocellular carcinoma (HCC). We showed the preferential uptake of DZ-1 by HCC cells in vitro and in derived subcutaneous/orthotopic tumour xenografts, accompanied by a minimal effect on normal cells. DZ-1 simplified tumour growth profiling as well, since we were able to correlate NIRF signals with tumour volume and/or tumour-emitting luminescence in mice...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28597139/hypoxia-and-bone-metastatic-disease
#13
REVIEW
Rachelle W Johnson, Miranda E Sowder, Amato J Giaccia
PURPOSE OF REVIEW: This review highlights our current knowledge of oxygen tensions in the bone marrow, and how low oxygen tensions (hypoxia) regulate tumor metastasis to and colonization of the bone marrow. RECENT FINDINGS: The bone marrow is a relatively hypoxic microenvironment, but oxygen tensions fluctuate throughout the marrow cavity and across the endosteal and periosteal surfaces. Recent advances in imaging have made it possible to better characterize these fluctuations in bone oxygenation, but technical challenges remain...
June 8, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28596947/molecular-mechanisms-of-hypoxia-in-cancer
#14
REVIEW
Amarnath Challapalli, Laurence Carroll, Eric O Aboagye
PURPOSE: Hypoxia is a condition of insufficient oxygen to support metabolism which occurs when the vascular supply is interrupted, or when a tumour outgrows its vascular supply. It is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. This review provides an overview of hypoxia imaging with Positron emission tomography (PET), with an emphasis on the biological relevance, mechanism of action, highlighting advantages, and limitations of the currently available hypoxia radiotracers...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28596740/ultrasound-imaging-of-mouse-fetal-intracranial-hemorrhage-due-to-ischemia-reperfusion
#15
Kenichi Funamoto, Takuya Ito, Kiyoe Funamoto, Clarissa L Velayo, Yoshitaka Kimura
Despite vast improvement in perinatal care during the 30 years, the incidence rate of neonatal encephalopathy remains unchanged without any further Progress towards preventive strategies for the clinical impasse. Antenatal brain injury including fetal intracranial hemorrhage caused by ischemia/reperfusion is known as one of the primary triggers of neonatal injury. However, the mechanisms of antenatal brain injury are poorly understood unless better predictive models of the disease are developed. Here we show a mouse model for fetal intracranial hemorrhage in vivo developed to investigate the actual timing of hypoxia-ischemic events and their related mechanisms of injury...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28596159/in-vivo-relationship-between-hypoxia-and-angiogenesis-in-human-glioblastoma-a-multimodal-imaging-study
#16
Keven Ferreira da Ponte, David Hassanein Berro, Solène Collet, Jean-Marc Constans, Evelyne Emery, Samuel Valable, Jean-Sébastien Guillamo
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. This aggressiveness is in part attributed to the closely interrelated phenomena, tumor hypoxia and angiogenesis, although few in vivo data exist in human brain tumors. This work aims to study hypoxia and angiogenesis, in vivo and in situ, in patients admitted with GBM using multimodal imaging. Methods: 23 GBM patients were assessed by [(18)F]-FMISO PET and conventional and perfusion MRI prior to surgery. The level and location of hypoxia ([(18)F]-FMISO uptake, evaluated by tumor/blood ratio, T/B), vascularization (cerebral blood volume, CBV) and vascular permeability (contrast enhancement after gadolinium injection) were analyzed...
June 8, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28592123/sorafenib-inhibits-growth-of-hepatoma-with-hypoxia-and-hypoxia-driven-angiogenesis-in-nude-mice
#17
F Li, F Wang, J Wu
The study aimed to investigate the effects of sorafenib on growth of hepatoma with hypoxia and angiogenesis. Green fluorescent protein (GFP)-expressing SMMC-7721 hepatoma cells were established via transfection with a lentiviral vector carrying GFP. GFP-labelled cells were treated with CoCl2 for 24 h with or without pretreatment of sorafenib for 30 min, and then injected subcutaneously into nude mice to induce hepatoma xenografts. This study used 16 BALB/c nude mice, which were divided into 4 groups: control group (GFP-labelled cells), CoCl2 group (GFP-labelled cells treated with CoCl2), CoCl2 plus sorafenib group (GFP-labelled cells pretreated with sorafenib and then treated with CoCl2) and CoCl2 plus sorafenib (cell+i...
June 8, 2017: Neoplasma
https://www.readbyqxmd.com/read/28588038/the-amp-related-kinase-ampk-induces-ca-2-independent-dilation-of-resistance-arteries-by-interfering-with-actin-filament-formation
#18
Kai M Schubert, Jiehua Qiu, Stephanie Blodow, Margarethe Wiedenmann, Lubomir T Lubomirov, Gabriele Pfitzer, Ulrich Pohl, Holger Schneider
Rationale: Decreasing Ca(2+) sensitivity of vascular smooth muscle (VSM) allows for vasodilation without lowering of cytosolic Ca(2+) This may be particularly important in states requiring maintained dilation such as hypoxia. AMPK is an important cellular energy sensor in VSM. Regulation of Ca(2+) sensitivity usually is attributed to myosin light chain phosphatase (MLCP) activity but findings in non-VSM identified changes in the actin cytoskeleton. The potential role of AMPK in this setting is widely unknown...
June 6, 2017: Circulation Research
https://www.readbyqxmd.com/read/28585762/upregulation-of-the-long-non-coding-rna-falec-promotes-proliferation-and-migration-of-prostate-cancer-cell-lines-and-predicts-prognosis-of-pca-patients
#19
Ruizhe Zhao, Feng Sun, Xiaoyu Bei, Xingjie Wang, Yiping Zhu, Chenyi Jiang, Fujun Zhao, Bangmin Han, Shujie Xia
BACKGROUND: LncRNAs are aberrantly expressed in various cancer types and were found to be a responsible prognosis biomarker and therapeutic target of many human cancers. METHODS: In this study, we characterized the expression profile of FALEC in prostate cancer and paired histologically normal tissues. Additionally, biological function of FALEC in prostate cancer cell lines was determined by in vitro and in vivo assays. RESULTS: In a total of 85 patients, FALEC expression was significantly increased in clinical PCa tissues compared to adjacent normal tissues, and can be considered as an independent prognostic factor in patients with PCa...
June 6, 2017: Prostate
https://www.readbyqxmd.com/read/28584786/nirf-heptamethine-cyanine-dye-nanocomplexes-for-multi-modal-theranosis-of-tumors
#20
REVIEW
Reju George Thomas, Yong Yeon Jeong
Heptamethine cyanine dyes are categorized as a class of near infrared fluorescent (NIRF) dyes which have been discovered to have tumor targeting and accumulation capability. This unique feature of NIRF dye makes it a promising candidate for imaging, targeted therapy and also as a drug delivery vehicle for various types of cancers. The favored uptake of dyes only in cancer cells is facilitated by several factors which include organic anion-transporting polypeptides, high mitochondrial membrane potential and tumor hypoxia in cancer cells...
May 2017: Chonnam Medical Journal
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