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Chronic Lyme Disease

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https://www.readbyqxmd.com/read/27914746/a-critical-appraisal-of-the-mild-axonal-peripheral-neuropathy-of-late-neurologic-lyme-disease
#1
REVIEW
Gary P Wormser, Franc Strle, Eugene D Shapiro, Raymond J Dattwyler, Paul G Auwaerter
In older studies, a chronic distal symmetric sensory neuropathy was reported as a relatively common manifestation of late Lyme disease in the United States. However, the original papers describing this entity had notable inconsistencies and certain inexplicable findings, such as reports that this condition developed in patients despite prior antibiotic treatment known to be highly effective for other manifestations of Lyme disease. More recent literature suggests that this entity is seen rarely, if at all. A chronic distal symmetric sensory neuropathy as a manifestation of late Lyme disease in North America should be regarded as controversial and in need of rigorous validation studies before acceptance as a documented clinical entity...
November 12, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27911694/seroprevalence-of-babesia-microti-in-individuals-with-lyme-disease
#2
Sabino R Curcio, Laurel P Tria, Azad L Gucwa
INTRODUCTION: Babesiosis is an emerging tick-borne disease (TBD) caused by Babesia microti, an intracellular parasite of red blood cells. Currently, it is the highest ranked pathogen transmitted by blood transfusion. Most healthy individuals infected with B. microti are asymptomatic, but may be at risk for chronic infection. Similar to Lyme disease transmitted by Borrelia burgdorferi, B. microti is spread by Ixodes scapularis ticks. The rate of coinfection with these TBDs in humans is unclear as most studies have focused their prevalence in ticks or rodent reservoirs...
December 2016: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/27883377/borrelia-burgdorferi-%C3%A2-morphological-structure-and-motility-as-adaptation-for-transmission-and-survival-in-the-habitat-of-a-tick-vertebrate-setup
#3
Paweł Penza, Anna Moniuszko-Malinowska, Piotr Czupryna, Sławomir Pancewicz, Joanna Zajkowska
Lyme borreliosis is a multisystem chronic disease caused by Borrelia burgdorferi sensu lato (s.l.) spirochete transmitted by Ixodes. This bacterium has a remarkable ability to survive in tick-vertebrate setup. Its infection causes diagnostic and clinical difficulties. It was distinguished as a separate disease entity over 30 years ago. Observations made by Steere et al. proved to be a milestone since they found correlation between the occurrence of skin and joint lesions with tick bites. Further studies showed that the disease affects not only joints and skin, but also nervous and circulatory systems...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27809728/does-lyme-disease-exist-in-australia
#4
Peter J Collignon, Gary D Lum, Jennifer Mb Robson
There is no convincing evidence that classic Lyme disease occurs in Australia, nor is there evidence that the causative agent, Borrelia burgdorferi, is found in Australian animals or ticks. Lyme disease, however, can be acquired overseas but diagnosed in Australia; most people presenting with laboratory-confirmed Lyme disease in Australia were infected in Europe. Despite the lack of evidence that Lyme disease can be acquired in Australia, growing numbers of patients, their supporters, and some politicians demand diagnoses and treatment according to the protocols of the "chronic Lyme disease" school of thought...
November 7, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27806082/metagenomic-investigation-of-plasma-in-individuals-with-me-cfs-highlights-the-importance-of-technical-controls-to-elucidate-contamination-and-batch-effects
#5
Ruth R Miller, Miguel Uyaguari-Diaz, Mark N McCabe, Vincent Montoya, Jennifer L Gardy, Shoshana Parker, Theodore Steiner, William Hsiao, Matthew J Nesbitt, Patrick Tang, David M Patrick
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease causing indefinite fatigue. ME/CFS has long been hypothesised to have an infectious cause; however, no specific infectious agent has been identified. We used metagenomics to analyse the RNA from plasma samples from 25 individuals with ME/CFS and compare their microbial content to technical controls as well as three control groups: individuals with alternatively diagnosed chronic Lyme syndrome (N = 13), systemic lupus erythematosus (N = 11), and healthy controls (N = 25)...
2016: PloS One
https://www.readbyqxmd.com/read/27775763/antibiotic-treatment-for-chronic-lyme-disease-say-no-to-the-dress
#6
Clifford M Marks, John E Nawn, Julie A Caplow
No abstract text is available yet for this article.
December 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27755213/controversies-in-persistent-chronic-lyme-disease
#7
Elizabeth L Maloney
The Centers for Disease Control and Prevention estimates that more than 300 000 new cases of Lyme disease occur each year in the United States and that 10% to 20% of these patients will remain symptomatic despite receiving appropriate antibiotic therapy. Many elements of the disease are poorly understood and have generated considerable controversy. This paper discusses the medical controversies related to posttreatment manifestations and their potential impact on infusion nurses.
November 2016: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/27744511/actin-dependent-regulation-of-borrelia-burgdorferi-phagocytosis-by-macrophages
#8
Xenia Naj, Stefan Linder
The spirochete Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting primarily skin, nervous system, and joints. If an infection with Borrelia proceeds unchecked, the disease can also enter a chronic stage, leading to the development of neuroborreliosis or cardiac arrhythmia. Successful elimination of B. burgdorferi by the host immune system is thus decisive for the positive outcome of a respective infection. Accordingly, host immune cells such as macrophages and dendritic cells have to be able to efficiently internalize and degrade infecting spirochetes...
October 16, 2016: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/27726376/immunogenic-hla-dr-presented-self-peptides-identified-directly-from-clinical-samples-of-synovial-tissue-synovial-fluid-or-peripheral-blood-in-patients-with-rheumatoid-arthritis-or-lyme-arthritis
#9
Qi Wang, Elise E Drouin, Chunxiang Yao, Jiyang Zhang, Yu Huang, Deborah R Leon, Allen C Steere, Catherine E Costello
HLA-DR-molecules are highly expressed in synovial tissue (ST), the target of the immune response in chronic inflammatory forms of arthritis. Here, we used LC-MS/MS to identify HLA-DR-presented self-peptides in cells taken directly from clinical samples: ST, synovial fluid mononuclear cells (SFMC), or peripheral blood mononuclear cells (PBMC) from five patients with rheumatoid arthritis (RA) and eight with Lyme arthritis (LA). We identified 1,593 non-redundant HLA-DR-presented peptides, derived from 870 source proteins...
October 11, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27585218/the-eye-and-tick-borne-disease-in-the-united-states
#10
Saraniya Sathiamoorthi, Wendy M Smith
PURPOSE OF REVIEW: Tick-borne diseases are increasing in incidence and geographic distribution. Several diseases endemic to the United States have ophthalmic manifestations, including the most common tick-borne disease, Lyme borreliosis. As ocular complaints may lead a patient to seek medical evaluation, it is important to be aware of the systemic and ophthalmic manifestations of tick-borne diseases in order to make the correct diagnosis. RECENT FINDINGS: Vision-threatening ophthalmic manifestations are relatively common in Lyme disease and Rocky Mountain spotted fever...
November 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27478852/texas-occurrence-of-lyme-disease-and-its-neurological-manifestations
#11
Jad A Dandashi, Damir Nizamutdinov, Samantha Dayawansa, Ekokobe Fonkem, Jason H Huang
Today, Lyme disease is the most commonly reported tick-borne disease in the United States and Europe. The culprits behind Lyme disease are the Borrelia species of bacteria. In the USA, Borrelia burgdorferi causes the majority of cases, while in Europe and Asia Borrelia afzelii and Borrelia garinii carry the greatest burden of disease. The clinical manifestations of Lyme disease have been identified as early localized, early disseminated, and late chronic. The neurological effects of Lyme disease include both peripheral and central nervous systems involvement, including focal nerve abnormalities, cranial neuropathies, painful radiculoneuritis, meningitis, and/or toxic metabolic encephalopathy, known as Lyme encephalopathy...
June 2016: Journal of Neuroinfectious Diseases
https://www.readbyqxmd.com/read/27440843/unique-expression-of-chronic-lyme-disease-and-jarisch-herxheimer-reaction-to-doxycycline-therapy-in-a-young-adult
#12
Chad Haney, Milap C Nahata
I am a 24-year-old male who was diagnosed with chronic Lyme disease after 4 years of multiple, non-specific symptoms. I have written this case as first author with my faculty mentor listed as the coauthor. The objective of this report is to highlight the experience with doxycycline treatment. In 2007, at around age 19 years, I had an acute onset of sore throat, tonsillitis, low-grade fever, stiff upper back and neck muscles, migraines and severely stiff, cracking jaw joints. This led to >24 medical visits, multitudes of tests and examinations, and exploratory surgery over the next 3 years...
July 20, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27213145/tocilizumab-efficacy-in-a-patient-with-positive-anti-ccp-chronic-lyme-arthritis
#13
Julianna Hirsch, Itzhak Rosner, Doron Rimar, Lisa Kaly, Michael Rozenbaum, Nina Boulman, Gleb Slobodin
CONTEXT: Lyme arthritis, a manifestation of tick-borne Lyme disease, can prove to be refractory to classic treatment. CASE REPORT: We present a case of a 48-year-old male, diagnosed with chronic Lyme arthritis, refractory to recurrent and prolonged courses of doxycycline, ceftriaxone, as well as hydroxychloroquine and methotrexate. The patient responded partially to tumor necrosis factor (TNF)-alpha blockade by etanercept and, finally, entered long-term remission after his treatment was switched to tocilizumab...
April 2016: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/27212252/the-joint-synovium-a-critical-determinant-of-articular-cartilage-fate-in-inflammatory-joint-diseases
#14
Pallavi Bhattaram, Unnikrishnan Chandrasekharan
The synovium constitutes the envelope of articular joints and is a critical provider of synovial fluid components and articular cartilage nutrients. Its inflammation is a predominant feature and cause of joint degeneration in diseases as diverse as rheumatoid, psoriatic, juvenile and idiopathic arthritis, and lupus, gout and lyme disease. These inflammatory joint diseases (IJDs) are due to a wide variety of genetic, epigenetic and environmental factors that trigger, promote, and perpetuate joint destabilization...
May 19, 2016: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/27170508/toll-like-receptors-and-chronic-inflammation-in-rheumatic-diseases-new-developments
#15
REVIEW
Leo A B Joosten, Shahla Abdollahi-Roodsaz, Charles A Dinarello, Luke O'Neill, Mihai G Netea
In the past few years, new developments have been reported on the role of Toll-like receptors (TLRs) in chronic inflammation in rheumatic diseases. The inhibitory function of TLR10 has been demonstrated. Receptors that enhance the function of TLRs, and several TLR inhibitors, have been identified. In addition, the role of the microbiome and TLRs in the onset of rheumatic diseases has been reported. We review novel insights on the role of TLRs in several inflammatory joint diseases, including rheumatoid arthritis, systemic lupus erythematosus, gout and Lyme arthritis, with a focus on the signalling mechanisms mediated by the Toll-IL-1 receptor (TIR) domain, the exogenous and endogenous ligands of TLRs, and the current and future therapeutic strategies to target TLR signalling in rheumatic diseases...
June 2016: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/27169474/ceftriaxone-induced-immune-hemolytic-anemia-as-a-life-threatening-complication-of-antibiotic-treatment-of-chronic-lyme-disease
#16
M De Wilde, M Speeckaert, R Callens, W Van Biesen
'Chronic Lyme disease' is a controversial condition. As any hard evidence is lacking that unresolved systemic symptoms, following an appropriately diagnosed and treated Lyme disease, are related to a chronic infection with the tick-borne spirochaetes of the Borrelia genus, the term 'chronic Lyme disease' should be avoided and replaced by the term 'post-treatment Lyme disease syndrome.' The improper prescription of prolonged antibiotic treatments for these patients can have an impact on the community antimicrobial resistance and on the consumption of health care resources...
May 12, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27101991/autophagy-suppresses-host-adaptive-immune-responses-toward-borrelia-burgdorferi
#17
Kathrin Buffen, Marije Oosting, Yang Li, Thirumala-Devi Kanneganti, Mihai G Netea, Leo A B Joosten
We have previously demonstrated that inhibition of autophagy increased the Borrelia burgdorferi induced innate cytokine production in vitro, but little is known regarding the effect of autophagy on in vivo models of Borrelia infection. Here, we showed that ATG7-deficient mice that were intra-articular injected with Borrelia spirochetes displayed increased joint swelling, cell influx, and enhanced interleukin-1β and interleukin-6 production by inflamed synovial tissue. Because both interleukin-1β and interleukin-6 are linked to the development of adaptive immune responses, we examine the function of autophagy on Borrelia induced adaptive immunity...
September 2016: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/27000820/-post-lyme-disease-syndrome
#18
REVIEW
Justyna Błaut-Jurkowska, Marcin Jurkowski
Lyme disease is a chronic infectious disease caused by the bacteria, spirochete of the Borrelia type. Skin, nervous system, musculoskeletal system and heart may be involved in the course of the disease. The prognosis for properly treated Lyme disease is usually good. However, in about 5% of patients so called Post-Lyme disease syndrome (PLSD) develops. It is defined as a syndrome of subjective symptoms persisting despite proper treatment of Borrelia burgdorferi infection. The most common symptoms include: fatigue, muscle and joint pain, and problems with memory and concentration...
February 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26954881/identification-of-new-compounds-with-high-activity-against-stationary-phase-borrelia-burgdorferi-from-the-nci-compound-collection
#19
Jie Feng, Wanliang Shi, Shuo Zhang, Ying Zhang
Lyme disease is the leading tick-borne disease in the USA. Whereas the majority of Lyme disease patients with early disease can be cured with standard treatment, some patients suffer from chronic fatigue and joint and muscular pain despite treatment, a syndrome called posttreatment Lyme disease syndrome. Although the cause is unclear, ineffective killing of Borrelia burgdorferi persisters by current Lyme disease antibiotics is one possible explanation. We took advantage of our recently developed high-throughput viability assay and screened the National Cancer Institute compound library collection consisting of 2526 compounds against stationary phase B...
2015: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/26873097/longitudinal-transcriptome-analysis-reveals-a-sustained-differential-gene-expression-signature-in-patients-treated-for-acute-lyme-disease
#20
Jerome Bouquet, Mark J Soloski, Andrea Swei, Chris Cheadle, Scot Federman, Jean-Noel Billaud, Alison W Rebman, Beniwende Kabre, Richard Halpert, Meher Boorgula, John N Aucott, Charles Y Chiu
UNLABELLED: Lyme disease is a tick-borne illness caused by the bacterium Borrelia burgdorferi, and approximately 10 to 20% of patients report persistent symptoms lasting months to years despite appropriate treatment with antibiotics. To gain insights into the molecular basis of acute Lyme disease and the ensuing development of post-treatment symptoms, we conducted a longitudinal transcriptome study of 29 Lyme disease patients (and 13 matched controls) enrolled at the time of diagnosis and followed for up to 6 months...
2016: MBio
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