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Chronic Lyme Disease

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https://www.readbyqxmd.com/read/29741589/c-reactive-protein-response-in-patients-with-post-treatment-lyme-disease-symptoms-versus-those-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#1
Melanie Uhde, Alyssa Indart, Brian A Fallon, Gary P Wormser, Adriana R Marques, Suzanne D Vernon, Armin Alaedini
No abstract text is available yet for this article.
May 8, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29706237/-pathway-to-diagnosis-and-real-life-experience-of-patients-believing-they-are-affected-by-chronic-lyme-disease
#2
E Forestier, F Gonnet, A Revil-Signorat, A C Zipper
OBJECTIVES: Chronic Lyme disease is a subject of scientific and social controversy in both Europe and the United States. The aim of our study was to analyze the pathway to diagnosis of patients believing they were affected by the disease, and to describe their real-life experience. METHOD: A qualitative study was performed with 13 patients declaring themselves to be affected by chronic Lyme disease. Interviews were analyzed by 2 general medical practice interns, supervised by a general practitioner with a diploma in socio-anthropology and an infectious diseases specialist...
April 26, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29513260/otolaryngological-symptoms-in-patients-treated-for-tick-borne-diseases
#3
Klaudia Sowula, Jacek Składzień, Joanna Szaleniec, Jolanta Gawlik
infections are borreliosis (Lyme disease) and tick-borne encephalitis (TBE). Lately there is growing incidence of Bartonella, Babesia, Anaplasma and Brucella co-infections. The similarity between the symptoms of tick-borne diseases and other pathologies causes serious diagnostic issues. MATERIAL AND METHODS: 216 patients aged 18-55, who presented to the outpatient clinic for tick-borne diseases in the years 2014-2016, were enrolled in the study. The patients had been diagnosed with Lyme disease and co-infections...
February 28, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29438352/the-financial-implications-of-a-well-hidden-and-ignored-chronic-lyme-disease-pandemic
#4
Marcus Davidsson
1 million people are predicted to get infected with Lyme disease in the USA in 2018. Given the same incidence rate of Lyme disease in Europe as in the USA, then 2.4 million people will get infected with Lyme disease in Europe in 2018. In the USA by 2050, 55.7 million people (12% of the population) will have been infected with Lyme disease. In Europe by 2050, 134.9 million people (17% of the population) will have been infected with Lyme disease. Most of these infections will, unfortunately, become chronic. The estimated treatment cost for acute and chronic Lyme disease for 2018 for the USA is somewhere between 4...
February 13, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29416466/exacerbation-of-chronic-pain-after-dental-extractions-in-a-patient-with-post-treatment-lyme-disease-syndrome
#5
Stephanie Lim, Sakura Kinjo
A subset of patients who had Lyme disease experience postinfectious signs or symptoms called post-treatment Lyme disease syndrome (PTLDS). PTLDS is a chronic condition including pain in joints and muscles, neurological symptoms including demyelinating diseases, peripheral neuropathy, headaches, sleep disturbances, fatigue, and cardiac conditions. We report a case of difficult acute pain management in a patient with PTLDS who underwent dental extractions and required admission to an intensive care unit for pain control...
January 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29402399/tick-borne-illness-lyme-disease
#6
REVIEW
Larry M Bush, Maria T Vazquez-Pertejo
Lyme disease is the most commonly reported tick-borneillness in the United States. Thecausative spirochete, Borrelia burgdorferi is transmitted by 4 species of Ixodes tick species. Over 90% of US cases occur in northeasternstates from Maine to Virginia, and in Wisconsin, Minnesota, and Michigan. Infection also takes place in northern California and Oregon. Lyme borreliosis is also diagnosed in parts of Europe, China, and Japan. The white-footed mouse is the primary animal reservoir for B. burgdorferi in the U...
February 2, 2018: Disease-a-month: DM
https://www.readbyqxmd.com/read/29359181/development-and-validation-of-a-serologic-test-panel-for-detection-of-powassan-virus-infection-in-u-s-patients-residing-in-regions-where-lyme-disease-is-endemic
#7
Angela M Thomm, Anna M Schotthoefer, Alan P Dupuis, Laura D Kramer, Holly M Frost, Thomas R Fritsche, Yvette A Harrington, Konstance K Knox, Sue C Kehl
Powassan virus (POWV) is an emerging tick-borne arbovirus presenting a public health threat in North America. POWV lineage II, also known as deer tick virus, is the strain of the virus most frequently found in Ixodes scapularis ticks and is implicated in most cases of POWV encephalitis in the United States. Currently, no commercial tests are available to detect POWV exposure in tick-borne disease (TBD) patients. We describe here the development and analytical validation of a serologic test panel to detect POWV infections...
January 2018: MSphere
https://www.readbyqxmd.com/read/29317049/autoimmunity-against-a-glycolytic-enzyme-as-a-possible-cause-for-persistent-symptoms-in-lyme-disease
#8
Paolo Maccallini, Serena Bonin, Giusto Trevisan
Some patients with a history of Borrelia burgdorferi infection develop a chronic symptomatology characterized by cognitive deficits, fatigue, and pain, despite antibiotic treatment. The pathogenic mechanism that underlines this condition, referred to as post-treatment Lyme disease syndrome (PTLDS), is currently unknown. A debate exists about whether PTLDS is due to persistent infection or to post-infectious damages in the immune system and the nervous system. We present the case of a patient with evidence of exposure to Borrelia burgdorferi sl and a long history of debilitating fatigue, cognitive abnormalities and autonomic nervous system issues...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29284115/straight-talk-about-chronic-lyme-disease
#9
EDITORIAL
Phillip J Baker
No abstract text is available yet for this article.
December 25, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29242055/late-disseminated-lyme-disease-associated-pathology-and-spirochete-persistence-posttreatment-in-rhesus-macaques
#10
Nicholas A Crossland, Xavier Alvarez, Monica E Embers
Nonhuman primates currently serve as the best experimental model for Lyme disease because of their close genetic homology with humans and demonstration of all three phases of disease after infection with Borrelia burgdorferi. We investigated the pathology associated with late disseminated Lyme disease (12 to 13 months after tick inoculation) in doxycycline-treated (28 days; 5 mg/kg, oral, twice daily) and untreated rhesus macaques. Minimal to moderate lymphoplasmacytic inflammation, with a predilection for perivascular spaces and collagenous tissues, was observed in multiple tissues, including the cerebral leptomeninges, brainstem, peripheral nerves from both fore and hind limbs, stifle synovium and perisynovial adipose tissue, urinary bladder, skeletal muscle, myocardium, and visceral pericardium...
March 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29190743/crystal-structure-of-a-tripartite-complex-between-c3dg-c-terminal-domains-of-factor-h-and-ospe-of-borrelia-burgdorferi
#11
Robert Kolodziejczyk, Kornelia M Mikula, Tommi Kotila, Vincent L G Postis, T Sakari Jokiranta, Adrian Goldman, Taru Meri
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis. The alternative pathway is tightly controlled to prevent autoactivation towards host cells. The main regulator of the alternative pathway is factor H (FH), a soluble glycoprotein that terminates complement activation in multiple ways. FH recognizes host cell surfaces via domains 19-20 (FH19-20). All microbes including Borrelia burgdorferi, the causative agent of Lyme borreliosis, must evade complement activation to allow the infectious agent to survive in its host...
2017: PloS One
https://www.readbyqxmd.com/read/29181956/infectious-diseases-in-poland-in-2015
#12
Małgorzata Sadkowska-Todys, Andrzej Zieliński, Mirosław P. Czarkowski
PURPOSE OF THE STUDY: This is the next annual analysis of the situation of infectious and parasitic diseases in Poland in 2015 within the framework of the Epidemiological Chronicle of Przegląd Epidemiologiczny - Epidemiological Review. Its purpose is to identify potential threats to the health of populations from infectious diseases occurring in Poland with reference to other parts of the globe. MATERIAL AND METHODS: This paper is an introduction to more detailed studies of the epidemiological situation of selected infectious diseases and summarizes the results of the surveillance of infectious diseases in Poland in 2015...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#13
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29075628/selective-essential-oils-from-spice-or-culinary-herbs-have-high-activity-against-stationary-phase-and-biofilm-borrelia-burgdorferi
#14
Jie Feng, Shuo Zhang, Wanliang Shi, Nevena Zubcevik, Judith Miklossy, Ying Zhang
Although the majority of patients with acute Lyme disease can be cured with the standard 2-4 week antibiotic treatment, about 10-20% of patients continue suffering from chronic symptoms described as posttreatment Lyme disease syndrome. While the cause for this is debated, one possibility is that persister bacteria are not killed by the current Lyme antibiotics and remain active in the system. It has been reported that essential oils have antimicrobial activities and some have been used by patients with persisting Lyme disease symptoms...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28987189/diseases-of-the-peripheral-nerves
#15
REVIEW
Istvan Katona, Joachim Weis
This chapter reviews the diseases of the peripheral nerves from a neuropathologic point of view, with a special focus on specific morphologic changes, and includes a summary of the histopathologic methods available for their diagnosis. As the rate of obesity and the prevalence of type 2 diabetes increase, diabetic neuropathy is the most common cause of peripheral neuropathy. Many systemic disorders with metabolic origin, like amyloidosis, hepatic failure, vitamin deficiencies, uremia, lipid metabolism disorders, and others, can also cause axonal or myelin alterations in the peripheral nervous system...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28873507/borrelia-burgdorferi-outer-surface-protein-c-ospc-binds-complement-component-c4b-and-confers-bloodstream-survival
#16
Jennifer A Caine, Yi-Pin Lin, Julie R Kessler, Hiromi Sato, John M Leong, Jenifer Coburn
Borrelia burgdorferi (Bb) is the causative agent of Lyme disease in the United States, a disease that can result in carditis, and chronic and debilitating arthritis and/or neurologic symptoms if left untreated. Bb survives in the midgut of the Ixodes scapularis tick, or within tissues of immunocompetent hosts. In the early stages of infection, the bacteria are present in the bloodstream where they must resist clearance by the innate immune system of the host. We have found a novel role for outer surface protein C (OspC) from B...
December 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28860873/effects-of-intravenous-ketamine-in-a-patient-with-post-treatment-lyme-disease-syndrome
#17
Ashraf F Hanna, Bishoy Abraham, Andrew Hanna, Adam J Smith
Post-treatment Lyme disease syndrome (PTLDS) is a pain disorder for which there remains no gold standard treatment option. Here, we report a case of PTLDS in a female patient whose pain was refractory to treatment options such as radiofrequency ablation, vitamin infusion therapy, opioid analgesics, and other pharmacotherapies. The patient commenced an experimental intravenous ketamine infusion therapy at the Florida Spine Institute (Clearwater, FL, USA) and achieved relief from her chronic pain, an improved quality of life, reduced depression and suicidal ideation, and reduced opioid consumption...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28840838/the-role-of-host-immune-cells-and-borrelia-burgdorferi-antigens-in-the-etiology-of-lyme-disease
#18
Dennis Verhaegh, Leo A B Joosten, Marije Oosting
Lyme disease is a zoonosis caused by infection with bacteria belonging to the Borrelia burgdorferi species after the bite of an infected tick. Even though an infection by this bacterium can be effectively treated with antibiotics, when the infection stays unnoticed B. burgdorferi can persist and chronic post-treatment Lyme disease syndrome is able to develop. Although a cellular and humoral response is observed after an infection with the Borrelia bacteria, these pathogens are still capable to stay alive. Several immune evasive mechanisms have been revealed and explained and much work has been put into the understanding of the contribution of the innate and adaptive immune response...
June 1, 2017: European Cytokine Network
https://www.readbyqxmd.com/read/28771127/interactions-between-host-immune-response-and-antigenic-variation-that-control-borrelia-burgdorferi-population-dynamics
#19
Wei Zhou, Dustin Brisson
The population dynamics of pathogens within hosts result from interactions between host immune responses and mechanisms of the pathogen to evade or resist immune responses. Vertebrate hosts have evolved adaptive immune responses to eliminate the infection, while many pathogens evade immune clearance through altering surface antigens. Such interactions can result in a characteristic pattern of pathogen population dynamics within hosts consisting of population growth after infection, rapid population decline following specific immune responses, followed by persistence at low densities during a chronic infection stage...
August 2017: Microbiology
https://www.readbyqxmd.com/read/28730326/infectious-diseases-causing-autonomic-dysfunction
#20
REVIEW
Francisco Javier Carod-Artal
OBJECTIVES: To review infectious diseases that may cause autonomic dysfunction. METHODS: Review of published papers indexed in medline/embase. RESULTS: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Autonomic dysfunction is relatively common in HIV-infected patients and heart rate variability is reduced even in early stages of infection...
February 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
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