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https://www.readbyqxmd.com/read/29342285/serial-participation-and-the-ethics-of-phase-1-healthy-volunteer-research
#1
Rebecca L Walker, Marci D Cottingham, Jill A Fisher
Phase 1 healthy volunteer clinical trials-which financially compensate subjects in tests of drug toxicity levels and side effects-appear to place pressure on each joint of the moral framework justifying research. In this article, we review concerns about phase 1 trials as they have been framed in the bioethics literature, including undue inducement and coercion, unjust exploitation, and worries about compromised data validity. We then revisit these concerns in light of the lived experiences of serial participants who are income-dependent on phase 1 trials...
January 12, 2018: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/29342070/an-evaluation-of-industry-relationships-among-contributors-to-aaos-clinical-practice-guidelines-and-appropriate-use-criteria
#2
Jake X Checketts, Courtney Cook, Matt Vassar
BACKGROUND: A long-standing relationship between orthopaedic surgeons and industry has made financial conflicts of interest a concerning issue. Research supports that financial conflicts of interest can influence both medical research and clinical practice. Financial conflicts of interest may also influence clinical practice guideline recommendations and their corresponding appropriate use criteria. Because of the influential nature of these guidelines, it is imperative that care be taken to minimize bias during guideline development...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29341509/effect-of-the-2008-economic-crisis-on-the-cardiovascular-mortality-of-the-irish-population-an-ecological-12-year-study-of-a-heart-broken-celtic-tiger
#3
M Osman, A Osman
Ireland has endured a substantial financial crisis in 2008 and we sought to explore the effect of economic recession on Irish cardiovascular mortality. We found an increase by 17.2% in CVA-deaths during the financial crisis years (95% CI 11.1% to 23.6%). In males, we found a notable rise in the annual IHD rate by 7.56% (95% CI 4.73% to 10.46%), in annual MI rate by 2.96% (95% CI 0.16% to 5.84%), and in annual CVA death rate by 20.07% (95% CI 16.13% to 24.14%). In females our findings indicated an increased rate of CVA-related deaths during the economic crisis by 15...
August 8, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29340939/the-influence-of-financial-strain-on-health-decision-making
#4
Oanh Kieu Nguyen, Robin T Higashi, Anil N Makam, Juan C Mijares, Simon Craddock Lee
No abstract text is available yet for this article.
January 16, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29340748/lack-of-level-i-evidence-on-how-to-prevent-infection-after-elective-shoulder-surgery
#5
Carola F Eck, Julie A Neumann, Orr Limpisvasti, Christopher R Adams
PURPOSE: Infection is a concern after all orthopedic procedures, including shoulder surgery. This systematic review of literature aimed to determine risk factors for infection as well as the availability and effectiveness of measures utilized to prevent infection after elective shoulder surgery. METHODS: An electronic database search was performed using MEDLINE (1950-October 2017), EMBASE (1980-October 2017), CINAHL (1982-October 2017), and the Cochrane database to identify studies reporting a risk factor or preventive measure for infection after shoulder surgery...
January 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29340705/author-correction-ouabain-attenuates-ovalbumin-induced-airway-inflammation
#6
José Guilherme F M Galvão, Luiz Henrique Agra Cavalcante-Silva, Deyse Cristina M Carvalho, Laércia Karla D P Ferreira, Talissa Mozzini Monteiro, Adriano Francisco Alves, Larissa Adiles M P Ferreira, Francisco Allysson A F Gadelha, Marcia Regina Piuvezam, Sandra Rodrigues-Mascarenhas
In the original publication, author missed to include the financial support from CAPES/PROCAD-2013. The complete funding text should read as follows.
January 16, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29340530/the-use-of-biosimilar-medicines-in-oncology-position-statement-of-the-brazilian-society-of-clinical-oncology-sboc
#7
G S Fernandes, C Sternberg, G Lopes, R Chammas, M A C Gifoni, R A Gil, D V Araujo
A biosimilar is a biologic product that is similar to a reference biopharmaceutical product, the manufacturing process of which hinders the ability to identically replicate the structure of the original product, and therefore, it cannot be described as an absolute equivalent of the original medication. The currently available technology does not allow for an accurate copy of complex molecules, but it does allow the replication of similar molecules with the same activity. As biosimilars are about to be introduced in oncology practice, these must be evaluated through evidence-based medicine...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29338955/declining-health-related-quality-of-life-in-the-u-s
#8
Mark Olfson, Melanie Wall, Shang-Min Liu, Michael Schoenbaum, Carlos Blanco
INTRODUCTION: Despite recent declining mortality of the U.S. population from most leading causes, uncertainty exists over trends in health-related quality of life. METHODS: The 2001-2002 and 2012-2013 National Epidemiologic Surveys on Alcohol and Related Conditions U.S. representative household surveys were analyzed for trends in health-related quality of life (n=79,402). Health-related quality of life was measured with the Short Form-6 Dimension scale derived from the Short Form-12...
January 12, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29338951/small-incentives-improve-weight-loss-in-women-from-disadvantaged-backgrounds
#9
Tricia M Leahey, Jessica Gokee LaRose, Marc S Mitchell, Carnisha M Gilder, Rena R Wing
INTRODUCTION: Women from lower-income backgrounds have the highest rates of obesity. Thus, effective programs for this high-risk population are urgently needed. Evidence suggests that adding financial incentives to treatment helps to engage and promote health behavior change in lower-income populations; however, this has never been tested in women for obesity treatment. The purpose of this study was to examine whether adding small financial incentives to Internet weight loss treatment yields better weight loss outcomes in women from lower-income backgrounds compared with the same treatment without incentives...
January 12, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29338915/the-significance-of-avoiding-household-food-waste-a-means-end-chain-approach
#10
Beate Richter, Wolfgang Bokelmann
Many humans suffer from hunger, while edible food is discarded. This study aims at showing the importance of avoiding food waste in households and its causes by applying the means-end-chain analysis. Additional the means-end-chain approach should be examined in how far the method is suitable to get insights towards this topic. Consumer backgrounds in terms of feelings and attitudes regarding food waste should be shown, with the particular question why food waste personally is important. The data collection occurred utilizing the hard laddering method within a quantitative online survey...
January 12, 2018: Waste Management
https://www.readbyqxmd.com/read/29338879/identifying-lost-surgical-needles-with-visible-and-near-infrared-fluorescent-light-emitting-microscale-coating
#11
Erin P Ward, Jian Yang, Jonathan C Delong, Tsai-Wen Sung, James Wang, Chris Barback, Natalie Mendez, Santiago Horgan, William Trogler, Andrew C Kummel, Sarah L Blair
BACKGROUND: Retained foreign bodies (RFOs) have substantial clinical and financial consequences. In laparoscopic surgery, RFOs can be a cause of needing to convert a minimally invasive surgery (MIS) procedure to an open operation. A coating for surgical models was developed to augment localization of needles using fluorescence appropriate for open and minimally invasive surgeries procedures. METHODS: An epoxy matrix containing both dansyl chloride and indocyanine green was coated as visible and near infrared labels, respectively...
January 12, 2018: Surgery
https://www.readbyqxmd.com/read/29338753/examining-within-and-across-day-relationships-between-transient-and-chronic-stress-and-parent-food-related-parenting-practices-in-a-racially-ethnically-diverse-and-immigrant-population-stress-types-and-food-related-parenting-practices
#12
Jerica M Berge, Allan Tate, Amanda Trofholz, Angela Fertig, Scott Crow, Dianne Neumark-Sztainer, Michael Miner
BACKGROUND: Although prior research suggests that stress may play a role in parent's use of food-related parenting practices, it is unclear whether certain types of stress (e.g., transient, chronic) result in different food-related parenting practices. Identifying whether and how transient (i.e., momentary; parent/child conflict) and chronic (i.e., long-term; unemployment >6 months) sources of stress are related to parent food-related parenting practices is important with regard to childhood obesity...
January 16, 2018: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29338578/cannabis-use-is-associated-with-lower-odds-of-prescription-opioid-analgesic-use-among-hiv-infected-individuals-with-chronic-pain
#13
Nancy L Sohler, Joanna L Starrels, Laila Khalid, Marcus A Bachhuber, Julia H Arnsten, Shadi Nahvi, John Jost, Chinazo O Cunningham
BACKGROUND: Chronic pain is common in the United States and prescribed opioid analgesics use for noncancer pain has increased dramatically in the past two decades, possibly accounting for the current opioid addiction epidemic. Co-morbid drug use in those prescribed opioid analgesics is common, but there are few data on polysubstance use patterns. OBJECTIVE: We explored patterns of use of cigarette, alcohol, and illicit drugs in HIV-infected people with chronic pain who were prescribed opioid analgesics...
January 17, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29338277/assessment-of-inpatient-psychiatric-readmission-risk-among-patients-discharged-on-an-antipsychotic-polypharmacy-regimen-a-retrospective-cohort-study
#14
Esad Boskailo, Aldin Malkoc, Dustin B McCurry, Jacob Venter, David Drachman, Gilbert M Ramos
OBJECTIVE: Patients are frequently prescribed multiple antipsychotic medications, leading to higher healthcare costs and increased risk for side effects. The efficacy of multiple versus single antipsychotics to prevent acute relapse, measured by incidence of inpatient readmission, is investigated in Arizona, USA. METHOD: A retrospective chart review compared socio-demographic and clinical data from 1,010 patients discharged on a single and 377 discharged on multiple antipsychotic medications...
November 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/29338071/the-financial-burden-and-distress-of-patients-with-cancer-understanding-and-stepping-up-action-on-the-financial-toxicity-of-cancer-treatment
#15
REVIEW
Pricivel M Carrera, Hagop M Kantarjian, Victoria S Blinder
"Financial toxicity" has now become a familiar term used in the discussion of cancer drugs, and it is gaining traction in the literature given the high price of newer classes of therapies. However, as a phenomenon in the contemporary treatment and care of people with cancer, financial toxicity is not fully understood, with the discussion on mitigation mainly geared toward interventions at the health system level. Although important, health policy prescriptions take time before their intended results manifest, if they are implemented at all...
January 16, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29337686/forgotten-public-health-impacts-of-cancer-an-overview
#16
Susana Viegas, Carina Ladeira, Ana Costa-Veiga, Julian Perelman, Goran Gajski
Cancer is one of the diseases of greatest concern in developed countries and much effort has been invested in discovering and developing therapeutics for curing cancer. Despite the improvements in antineoplastic therapeutics in the last decades, cancer is still one of the most harmful diseases worldwide. The global burden of cancer also implies financial costs: these can be direct costs, such as those related to treatment, care, and rehabilitation and indirect, which include the loss of economic output due to missed work (morbidity costs) and premature death (mortality costs)...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29337399/impact-of-pregnancy-on-psychoactive-substance-use-among-women-with-substance-use-disorders-recruited-in-addiction-specialized-care-centers-in-france
#17
Liselotte Pochard, Julie Dupouy, Elisabeth Frauger, Adeline Giocanti, Joëlle Micallef, Maryse Lapeyre-Mestre
Pregnancy can be a motivation for decrease in drug abusing but may also represent a period of high vulnerability for relapse.We aimed to assess psychoactive substance use among women with substance use disorders followed in addiction care centers in France. We analyzed data from women aged 15-44 years included in the 'Observation of illegal drugs and misuse of psychotropic medication survey' (OPPIDUM), an annualcross-sectional survey collecting details on psychoactive substances used. Characteristics of women included in 2005 to 2012 yearly surveys were compared depending on their pregnant or not pregnant status...
January 16, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29336633/the-relationship-between-asthma-and-depression-in-a-community-based-sample
#18
Mahima Akula, Alexandra Kulikova, David A Khan, E Sherwood Brown
OBJECTIVE: Asthma is an increasingly prevalent disease that is associated with substantial physical and financial burdens. Additionally, asthma is linked to psychiatric disorders. This study examines the relationship between asthma diagnosis, current depressive symptoms, and lifetime psychiatric disorder history in a large, community-based sample. METHODS: We analyzed data from 2168 participants in the Dallas Heart Study, a large, diverse, community-based sample of people designed to be representative of the Dallas County population...
January 16, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29336213/heart-versus-head-differential-bodily-feedback-causally-alters-economic-decision-making
#19
Philip A Powell, Kaisa Puustinen-Hopper, Martin de Jode, Panagiotis Mavros, Jennifer Roberts
Metaphorically, altruistic acts, such as monetary donations, are said to be driven by the heart, whereas sound financial investments are guided by reason, embodied by the head. In a unique experiment, we tested the effects of these bodily metaphors using biofeedback and an incentivized economic decision-making paradigm. Participants played a repeated investment game with a simulated partner, alternating between tactical investor and altruistic investee. When making decisions, participants received counterbalanced visual feedback from their own or a simulated partner's heart or head, as well as no feedback...
October 1, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/29335745/-health-privacy-in-the-age-of-digital-networks
#20
REVIEW
Thilo Weichert
Digitization in the health sector embodies opportunities and risks. These consist of patient and data confidentiality. Vulnerability of data concerning integrity and availability can lead to financial losses and to damage of the health of data subjects. Those risks must be tackled by privacy or data protection law. For this purpose we have the European Data Protection Regulation as a comprehensive legal framework and a harmonizing bracket.This framework contains regulations on consent, purpose binding and data transfer, on rights of the data subject, technical and organizational measures and procedural arrangements...
January 15, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
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