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Wound healing by electricity

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https://www.readbyqxmd.com/read/29343055/genetically-encoded-circuit-for-remote-regulation-of-cell-migration-by-magnetic-fields
#1
Abdullah Al Mosabbir, Kevin Truong
Magneto-reception can be generally defined as the ability to transduce the effects of a magnetic field into a cellular response. Magnetic stimulation at the cellular level is particularly attractive due to its ability for deep penetration and minimal invasiveness, allowing remote regulation of engineered biological processes. Previously, a magnetic-responsive genetic circuit was engineered using the transient receptor potential vanilloid 1 (TRPV1) and the iron containing ferritin protein (i.e. the TF circuit)...
January 17, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29309334/retrospective-review-of-free-anterolateral-thigh-flaps-for-limb-salvage-in-severely-injured-high-voltage-electrical-burn-patients
#2
Jing-Chun Zhao, Kai Shi, Lei Hong, Zheng-Hua Jin, Xi Zhang, Xin-Xin Gao, Jia-Ao Yu
BACKGROUND: High-voltage electrical injuries usually cause extensive and devastating damages to the extremities. Timely and effective coverage of the wounds to maximally preserve the viable tissue is important for salvage and the ultimate functional outcome of the involved extremities. In this study, free anterolateral thigh flaps with a single-perforator pedicle were conducted to maximize tissue salvage and decrease late skeletal and neuromuscular complications of the involved extremities injured by high-voltage electricity...
January 5, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29277016/apolipoprotein-a-1-mimetic-peptide-4f-promotes-endothelial-repairing-and-compromises-reendothelialization-impaired-by-oxidized-hdl-through-sr-b1
#3
Dan He, Mingming Zhao, Congying Wu, Wenjing Zhang, Chenguang Niu, Baoqi Yu, Jingru Jin, Liang Ji, Belinda Willard, Anna V Mathew, Y Eugene Chen, Subramaniam Pennathur, Huiyong Yin, Yuan He, Bing Pan, Lemin Zheng
Disruption of endothelial monolayer integrity is the primary instigating factor for many cardiovascular diseases. High density lipoprotein (HDL) oxidized by heme enzyme myeloperoxidase (MPO) is dysfunctional in promoting endothelial repair. Apolipoprotein A-1 mimetic 4F with its pleiotropic benefits has been proven effective in many in vivo models. In this study we investigated whether 4F promotes endothelial repair and restores the impaired function of oxidized HDL (Cl/NO2-HDL) in promoting re-endothelialization...
December 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/29275614/-wound-repair-and-functional-reconstruction-of-high-voltage-electrical-burns-in-wrists
#4
Y M Shen, C X Ma, F J Qin, C Zhang, C Wang, X H Hu
Objective: To explore the methods and effects of wound repair and functional reconstruction of high-voltage electrical burns in wrists. Methods: From January 2009 to June 2016, 71 patients with high-voltage electrical burns in wrists were hospitalized, with 118 wrist wounds including 21 of type Ⅰ, 69 of type Ⅱ, 9 of type Ⅲ, and 19 of type Ⅳ. According to the wrist injuries, different surgical operations were performed. Forearm amputation was conducted in 20 wrists with necrosis in the distal end. On the basis of fasciotomy for decompression, early debridement was performed on the other 98 wrist wounds...
December 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29262296/electroactive-biomaterials-vehicles-for-controlled-delivery-of-therapeutic-agents-for-drug-delivery-and-tissue-regeneration
#5
Biranche Tandon, Adrián Magaz, Richard Balint, Jonny J Blaker, Sarah H Cartmell
Electrical stimulation for delivery of biochemical agents such as genes, proteins and RNA molecules amongst others, holds great potential for controlled therapeutic delivery and in promoting tissue regeneration. Electroactive biomaterials have the capability of delivering these agents in a localized, controlled, responsive and efficient manner. These systems have also been combined for the delivery of both physical and biochemical cues and can be programmed to achieve enhanced effects on healing by establishing control over the microenvironment...
December 17, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29127941/improving-anti-adhesion-performance-of-electrosurgical-electrode-assisted-with-ultrasonic-vibration
#6
Guang Yao, Deyuan Zhang, Daxi Geng, Xinggang Jiang
The electrosurgical electrode currently stands out as one of the most commonly used tools in minimally invasive surgery. In order to facilitate tissue cutting and accelerate wound healing, tissue adhesion to the electrosurgical electrode is considered as an extremely urgent problem to be solved. In this paper, a novel ultrasonic vibration assisted (UV-A) electrosurgical electrode is firstly proposed to overcome the problem of tissue sticking. The anti-adhesion effects were evaluated by measuring the adhesion force and the weight of tissue adhesion using the electrosurgical electrode with and without UV-A comparatively...
October 20, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29115573/fibroblast-activation-protein-%C3%AE-promotes-the-growth-and-migration-of-lung-cancer-cells-via-the-pi3k-and-sonic-hedgehog-pathways
#7
Jun Jia, Tracey A Martin, Lin Ye, Lin Meng, Nan Xia, Wen G Jiang, Xiaodong Zhang
A characteristic of the epithelial-to-mesenchymal transition in cancer cells is the upregulation of mesenchymal markers. Fibroblast activation protein α (FAPα) is predominantly expressed by stromal fibroblasts. Previous studies have demonstrated that FAPα is also expressed by certain epithelium-derived cancer cells and is involved in the regulation of certain signaling pathways. One of our previous studies showed that FAPα promoted the proliferation of breast cancer cells via the phosphatidylinositol-3-kinase (PI3K) signaling pathway...
October 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29099398/electric-field-based-dressing-disrupts-mixed-species-bacterial-biofilm-infection-and-restores-functional-wound-healing
#8
Kasturi Ganesh Barki, Amitava Das, Sriteja Dixith, Piya Das Ghatak, Shomita Mathew-Steiner, Elizabeth Schwab, Savita Khanna, Daniel J Wozniak, Sashwati Roy, Chandan K Sen
OBJECTIVE: This study was designed to employ electroceutical principles, as an alternative to pharmacological intervention, to manage wound biofilm infection. Mechanism of action of a United States Food and Drug Administration-cleared wireless electroceutical dressing (WED) was tested in an established porcine chronic wound polymicrobial biofilm infection model involving inoculation with Pseudomonas aeruginosa PAO1 and Acinetobacter baumannii 19606. BACKGROUND: Bacterial biofilms represent a major wound complication...
November 2, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29052946/hierarchical-evaluation-of-electrical-stimulation-protocols-for-chronic-wound-healing-an-effect-size-meta-analysis
#9
Charles Khouri, Sylvain Kotzki, Matthieu Roustit, Sophie Blaise, Francois Gueyffier, Jena-Luc Cracowski
Electrical stimulation (ES) has been tested for decades to improve chronic wound healing. However, uncertainty remains on the magnitude of the efficacy and on the best applicable protocol. We conducted an effect size meta-analysis to assess the overall efficacy of ES on wound healing, to compare the efficacy of the different modalities of electrical stimulation, and to determine whether efficacy differs depending on the wound etiology, size and age of the chronic wound. Twenty-nine randomized clinical trials with 1510 patients and 1753 ulcers were selected...
October 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29022636/the-effect-of-anthocyanins-from-red-wine-and-blackberry-on-the-integrity-of-a-keratinocyte-model-using-ecis
#10
Ana Évora, Victor de Freitas, Nuno Mateus, Iva Fernandes
There is a growing market demand for the incorporation of plant-derived ingredients into new products for the cosmetic industry. Anthocyanins are polyphenols arising from plant secondary metabolism that have been shown to possess many bioactive properties such as free radical scavenging, antimicrobial, and chemopreventive activities. In this work, the biological activities of red wine and blackberry anthocyanins were assessed by developing a new keratinocyte barrier model using the HaCat cell line and a microelectrode-based biosensor device, referred to as Electric Cell-Substrate Impedance Sensing (ECIS)...
October 12, 2017: Food & Function
https://www.readbyqxmd.com/read/29022267/cardiac-fibrosis-the-beneficial-effects-of-exercise-in-cardiac-fibrosis
#11
Jan Kyselovič, John J Leddy
Numerous scientific findings have concluded that individuals who are active tend to develop less cardiovascular disease than those who enjoy more sedentary lifestyles. Animal models have further demonstrated that the beneficial effects of training on the heart effects of training are related to the signaling pathways of myocardial hypertrophy and fibrosis. As such, fibroblasts represent a very important population of cells within the myocardium as they play a crucial role in both cardiac development and response to injury...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28932886/immediate-responses-of-the-cockroach-blaptica-dubia-after-the-exposure-to-sulfur-mustard
#12
Tanja Popp, Robin Lüling, Ingrid Boekhoff, Thomas Seeger, Francisco Branoner, Thomas Gudermann, Horst Thiermann, Franz Worek, Dirk Steinritz
The chemical agent sulfur mustard (SM) causes erythema, skin blisters, ulcerations, and delayed wound healing. It is accepted that the underlying molecular toxicology is based on DNA alkylation. With an expected delay, DNA damage causes impairment of protein biosynthesis and disturbance of cell division. However, using the cockroach model Blaptica dubia, the presented results show that alkylating compounds provoke immediate behavior responses along with fast changes in the electrical field potential (EFP) of neurons, suggesting that lesions of DNA are probably not the only effect of alkylating compounds...
September 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28930581/biophysical-mechanisms-complementing-classical-cell-biology
#13
Richard H W Funk
This overview addresses phenomena in cell- and molecular biology which are puzzling by their fast and highly coordinated way of organization. Generally, it appears that informative processes probably involved are more on the biophysical than on the classical biochemical side. The coordination problem is explained within the first part of the review by the topic of endogenous electrical phenomena. These are found e.g. in fast tissue organization and reorganization processes like development, wound healing and regeneration...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929631/accelerated-wound-healing-on-skin-by-electrical-stimulation-with-a-bioelectric-plaster
#14
Hiroyuki Kai, Takeshi Yamauchi, Yudai Ogawa, Ayaka Tsubota, Takahiro Magome, Takeo Miyake, Kenshi Yamasaki, Matsuhiko Nishizawa
Wound healing on skin involves cell migration and proliferation in response to endogenous electric current. External electrical stimulation by electrical equipment is used to promote these biological processes for the treatment of chronic wounds and ulcers. Miniaturization of the electrical stimulation device for wound healing on skin will make this technology more widely available. Using flexible enzymatic electrodes and stretchable hydrogel, a stretchable bioelectric plaster is fabricated with a built-in enzymatic biofuel cell (EBFC) that fits to skin and generates ionic current along the surface of the skin by enzymatic electrochemical reactions for more than 12 h...
November 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28880251/studying-electrotaxis-in-microfluidic-devices
#15
REVIEW
Yung-Shin Sun
Collective cell migration is important in various physiological processes such as morphogenesis, cancer metastasis and cell regeneration. Such migration can be induced and guided by different chemical and physical cues. Electrotaxis, referring to the directional migration of adherent cells under stimulus of electric fields, is believed to be highly involved in the wound-healing process. Electrotactic experiments are conventionally conducted in Petri dishes or cover glasses wherein cells are cultured and electric fields are applied...
September 7, 2017: Sensors
https://www.readbyqxmd.com/read/28865175/control-of-cell-growth-on-3d-printed-cell-culture-platforms-for-tissue-engineering
#16
Zhikai Tan, Tong Liu, Juchang Zhong, Yikun Yang, Weihong Tan
Biocompatible tissue growth has excellent prospects for tissue engineering. These tissues are built over scaffolds, which can influence aspects such as cell adhesion, proliferation rate, morphology, and differentiation. However, the ideal 3D biological structure has not been developed yet. Here, we applied the electro-hydrodynamic jet (E-jet) 3D printing technology using poly-(lactic-co-glycolic acid, PLGA) solution to print varied culture platforms for engineered tissue structures. The effects of different parameters (electrical voltage, plotting speed, and needle sizes) on the outcome were investigated...
December 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28823088/electrical-signals-triggered-controllable-formation-of-calcium-alginate-film-for-wound-treatment
#17
Xiaoli Liu, Huan Liu, Xue Qu, Miao Lei, Chuchu Zhang, Hua Hong, Gregory F Payne, Changsheng Liu
Wound dressings play important roles in the management of wounds, and calcium cross-linked alginate (Ca(2+)-Alg) is a commonly used hydrogel that is adapted for wound treatment. However, conventional methods for fabricating Ca(2+)-Alg hydrogels can be tedious and difficult to control because of the rapid Ca(2+)-induced gelation of alginate. In this study, An electrodeposition method was used to rapidly and controllably fabricate Ca(2+)-Alg films for wound treatment. Several measures of film growth (e.g., thickness and mass) are shown to linearly correlate to the imposed charge transfer at the electrode...
August 19, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28810546/changes-in-cell-junctions-induced-by-inhibition-of-epidermal-growth-factor-receptor-in-oral-squamous-cell-carcinoma-cells
#18
Yasumasa Kakei, Shun Teraoka, Masaya Akashi, Takumi Hasegawa, Takahide Komori
The benefits of epidermal growth factor receptor (EGFR) targeting in the treatment of head and neck cancer, have been documented. However, a minority of patients with head and neck cancer are unresponsive to EGFR targeting therapies. The present study evaluated the effects and limitations of an EGFR inhibitor on oral squamous cell carcinoma cells, particularly on cell-cell junctions mediated by epithelial (E)-cadherin. HSC-3 oral squamous cell carcinoma cells were treated with the EGFR inhibitor, AG1478 (0, 0...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28802553/effect-of-cold-argon-plasma-on-eggs-of-the-blow-fly-lucilia-cuprina-diptera-calliphoridae
#19
Kwankamol Limsopatham, Dheerawan Boonyawan, Chanchai Umongno, Kabkaew L Sukontason, Tarinee Chaiwong, Rattana Leksomboon, Kom Sukontason
Non-thermal plasma has been used in many medical applications, including treatment of living cells, blood coagulation, wound healing, and sterilization. The process uses an environmentally friendly gas (e.g., argon, helium, oxygen, nitrogen, or hydrogen) to destroy bacteria cells with no serious adverse effect on humans or animals. However, information on the effect of argon plasma on blow fly eggs is lacking. In this study, we explored the ability of cold argon plasma to destroy the eggs of the Australian sheep blow fly, Lucilia cuprina (Wiedemann, 1830); its larvae are a myiasis-producing agent in both human and animals...
December 2017: Acta Tropica
https://www.readbyqxmd.com/read/28763908/-effects-of-flow-through-descending-branch-of-lateral-circumflex-femoral-artery-flap-on-repairing-high-voltage-electrical-burn-wounds-of-wrist-of-patients
#20
Y M Shen, X Chen, C Zhang, C Wang, F J Qin, C X Ma, X H Hu
Objective: To investigate the effects of flow-through descending branch of lateral circumflex femoral artery flap on repairing high-voltage electrical burn wounds of wrist of patients. Methods: From January 2014 to June 2016, 5 patients with high-voltage electrical burn of unilateral wrist were hospitalized in our burn ward, with extensive necrosis of skin soft tissue of burn wrist. Five patients were transferred to our burn ward 6 to 12 days post injury after undergoing emergency dermotomy of wrist to reduce tension in other hospitals...
July 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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