keyword
MENU ▼
Read by QxMD icon Read
search

KL 6

keyword
https://www.readbyqxmd.com/read/27919567/splicing-factor-proline-glutamine-rich-is-a-novel-autoantigen-of-dermatomyositis-and-associated-with-anti-melanoma-differentiation-associated-gene-5-antibody
#1
Yuji Hosono, Ran Nakashima, Satoshi Serada, Kosaku Murakami, Yoshitaka Imura, Hajime Yoshifuji, Koichiro Ohmura, Tetsuji Naka, Tsuneyo Mimori
OBJECTIVE: Anti-MDA5 antibody positive dermatomyositis (DM) and clinically amyopathic DM (CADM) often develop into rapidly progressive interstitial lung disease, but their pathogenesis remains unclear. We observed that sera from DM/CADM patients immunoprecipitated a common 110 kDa polypeptide. We investigated this autoantigen and its clinical significance. METHODS: Autoantibodies were screened in 333 patients with various connective tissue diseases (CTDs) and 20 healthy controls (HCs) by immunoprecipitation with [(35)S]methionine-labeled HeLa cells...
December 2, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27915458/acl-deficiency-and-varus-osteoarthritis-high-tibial-osteotomy-alone-or-combined-with-acl-reconstruction
#2
Julian Mehl, Jochen Paul, Matthias J Feucht, Gerrit Bode, Andreas B Imhoff, Norbert P Südkamp, Stefan Hinterwimmer
INTRODUCTION: This study investigates the mid- to long-term clinical and radiological outcome in patients with symptomatic varus osteoarthritis (OA) and deficiency of the anterior cruciate ligament (ACL) and analyzes whether there are differences between isolated high tibial osteotomy (HTO) or combined single-stage HTO and ACL reconstruction (ACLR). METHODS: 26 patients who underwent HTO alone (group 1) and 26 patients who underwent single-stage HTO and ACLR (group 2) because of varus OA and ACL deficiency were examined at a mean of 5...
December 3, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27909787/test-retest-reliability-of-tibiofemoral-joint-space-width-measurements-made-using-a-low-dose-standing-ct-scanner
#3
Neil A Segal, John Bergin, Andrew Kern, Christian Findlay, Donald D Anderson
OBJECTIVE: To determine the test-retest reliability of knee joint space width (JSW) measurements made using standing CT (SCT) imaging. SUBJECTS AND METHODS: This prospective two-visit study included 50 knees from 30 subjects (66% female; mean ± SD age 58.2 ± 11.3 years; BMI 29.1 ± 5.6 kg/m(2); 38% KL grade 0-1). Tibiofemoral geometry was obtained from bilateral, approximately 20° fixed-flexed SCT images acquired at visits 2 weeks apart. For each compartment, the total joint area was defined as the area with a JSW <10 mm...
December 1, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27894935/brief-report-stage-specific-differences-in-secretory-profile-of-mesenchymal-stromal-cells-mscs-subjected-to-early-vs-late-stage-oa-synovial-fluid
#4
Alejandro Gómez-Aristizábal, Anirudh Sharma, Mohsen A Bakooshli, Mohit Kapoor, Penney M Gilbert, Sowmya Viswanathan, Rajiv Gandhi
OBJECTIVE: Although, mesenchymal stromal cells (MSCs) are being clinically investigated for their use in osteoarthritis (OA), it is unclear whether their postulated therapeutic properties are equally effective in the early- and late-stages of OA. In this study we investigated MSC cytokine secretion post-exposure to synovial fluid (SF), obtained from early-vs. late-stage knee OA patients to justify a potential patient stratification strategy to maximize MSC-mediated treatment effects. METHOD: Subjects were recruited and categorized into early- [Kellgren-Lawrence (KL) grade I/II, n = 12] and late-stage (KL-III/IV, n = 12) knee OA groups...
November 25, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27882773/the-acquisition-of-initial-consonant-clusters-in-german-speaking-2-year-olds
#5
Blanca Schaefer, Annette Fox-Boyer
PURPOSE: The aim of this study was to explore cluster acquisition in typically developing German-speaking 2-year-olds. METHOD: Data from four cross-sectional studies (n = 145, aged 2;00-2;11) and one eight-month longitudinal study were analysed (n = 6, aged 2;01-2;04). Two different percentages of consonant clusters correct were calculated to allow a more detailed analysis. RESULT: Findings showed that the majority of children produced clusters, although they could not be considered to be fully acquired...
November 24, 2016: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27861264/use-of-b-mode-ultrasound-as-a-body-fat-estimate-in-collegiate-football-players
#6
Parker N Hyde, Kristina L Kendall, Ciaran M Fairman, Nicholas A Coker, Mary E Yarbrough, Steve J Rossi
Hyde, PN, Kendall, KL, Fairman, CM, Coker, NA, Yarbrough, ME, and Rossi, SJ. Utilization of B-mode ultrasound as a body fat estimate in collegiate football players. J Strength Cond Res 30(12): 3525-3530, 2016-The purpose of the present study was to validate a 7-site ultrasound imaging protocol to predict the percent body fat (%BF) in a division I football team. Body composition was estimated by ultrasound, 7-site skinfolds, and the 3-compartment-water (3C-W) model of Siri, using bioimpedance spectroscopy to estimate the total body water and air displacement plethysmography (using BODPOD) to determine the body density...
December 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27852185/young-onset-colorectal-cancer-in-new-south-wales-a-population-based-study
#7
Stephen Boyce, Natasha Nassar, Cathy Yuen Yi Lee, Michael Kl Suen, Saleh Al Zahrani, Marc A Gladman
OBJECTIVE: Australia has the highest incidence of colorectal cancer (CRC) in the world. The incidence of young-onset CRC (yCRC) is increasing in developed nations. Our aim was to determine the incidence of yCRC in New South Wales, the demographic and clinico-pathological characteristics of these patients, and their survival. DESIGN, SETTING, PARTICIPANTS: A population-based cohort study of all cases of CRC diagnosed in NSW during 2001-2008. Data on newly diagnosed cases of CRC were obtained from the NSW Central Cancer Registry; mortality data were obtained from the NSW Registry of Births Deaths and Marriages (to 2012)...
November 21, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27835043/risk-factors-for-medial-tibial-stress-syndrome-in-active-individuals-an-evidence-based-review
#8
Zachary K Winkelmann, Dustin Anderson, Kenneth E Games, Lindsey E Eberman
: Reference/Citation: Hamstra-Wright KL, Bliven KC, Bay C. Risk factors for medial tibial stress syndrome in physically active individuals such as runners and military personnel: a systematic review and meta-analysis. Br J Sports Med. 2015;49(6)362-369. CLINICAL QUESTION:  What factors put physically active individuals at risk to develop medial tibial stress syndrome (MTSS)? DATA SOURCES:  The authors performed a literature search of CINAHL, the Cochrane Central Register of Controlled Trials, EMBASE, and MEDLINE from each database's inception to July 2013...
November 1, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27758986/the-value-of-biomarkers-as-predictors-of-outcome-in-patients-with-rheumatoid-arthritis-associated-usual-interstitial-pneumonia
#9
Young Seok Lee, Ho Cheol Kim, Bo Young Lee, Chang Keun Lee, Mi-Young Kim, Se Jin Jang, Hye Sun Lee, Jieun Moon, Thomas V Colby, Dong Soon Kim
BACKGROUND: Because of the highly variable clinical course of rheumatoid arthritis-associated usual interstitial pneumonia (RA-UIP), the prediction of patient prognosis is important. OBJECTIVE: The aim of this study was to investigate the role of blood biomarkers as prognostic predictors in the patients with RA-UIP. METHODS: The blood levels of biomarkers (Krebs von den Lungen-6 [KL-6], surfactant protein-A [SP-A], matrix metalloproteinase-7 [MMP-7], interleukin-6 [IL-6], and interleukin-32 [IL-32]) were retrospectively compared with the clinical courses of 62 patients with RA-UIP...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27746429/influence-of-smoking-in-interstitial-pneumonia-presenting-with-a-non-specific-interstitial-pneumonia-pattern
#10
Tetsuro Sawata, Masashi Bando, Masayuki Nakayama, Naoko Mato, Hideaki Yamasawa, Yukihiko Sugiyama
Objective The influence of smoking on the pathogenesis and clinical course of interstitial pneumonia has recently attracted attention. To clarify the influence of smoking on the clinical patient characteristics and therapeutic effects in patients with interstitial pneumonia presenting with a non-specific interstitial pneumonia (NSIP) pattern, we compared the clinical patient characteristics and therapeutic effects in smokers and nonsmokers in this study. Methods We divided 31 NSIP (16 idiopathic nonspecific interstitial pneumonia and 15 collagen vascular disease-associated nonspecific interstitial pneumonia) patients into smoker and non-smoker groups for each case...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27699034/analysis-of-blood-neutrophil-elastase-glutathione-levels-and-pathological-findings-in-postoperative-acute-exacerbation-of-idiopathic-pulmonary-fibrosis-associated-with-lung-cancer-two-case-reports
#11
Keishi Sugino, Yasuhiko Nakamura, Yoko Muramatsu, Yoshinobu Hata, Kazutoshi Shibuya, Sakae Homma
Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is characterized by severe worsening dyspnea and high mortality. It has been proven that the serum neutrophil elastase (NE) level, in addition to the serum Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) levels, was elevated in patients with IPF-AE. Glutathione (GSH) is the major antioxidant involved in cell metabolism and survival. It is also known that IPF is characterized by reduced GSH levels in bronchoalveolar lavage fluid and blood...
October 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27697006/meniscal-surgery-risk-of-radiographic-joint-space-narrowing-progression-and-subsequent-knee-replacement-data-from-the-osteoarthritis-initiative
#12
Bashir Zikria, Nima Hafezi-Nejad, Frank W Roemer, Ali Guermazi, Shadpour Demehri
Purpose To investigate the risk of radiographic joint space narrowing (JSN) progression evaluated in subjects with and those without underlying osteoarthritis at baseline and knee replacement (KR) associated with meniscal surgery in subjects with and those without a reported history of preceding knee trauma. Materials and Methods The HIPAA-compliant protocol was approved by the institutional review boards of the participating centers. Written informed consent was obtained from all participants. Subjects who underwent meniscal surgery with a preceding knee trauma at baseline (n = 564) and those without (n = 147) were drawn from the Osteoarthritis Initiative cohort (n = 4796)...
October 3, 2016: Radiology
https://www.readbyqxmd.com/read/27676834/quality-of-life-for-patient-with-knee-osteoarthritis
#13
Samia Frioui Mahmoudi, Emna Toulgui, Khalil Ben Jeddou, Mariem Gaddour, Sonia Jemni, Faycel Khachnaoui
OBJECTIVE: The objective of this study is to evaluate the quality of life of patients complaining of knee osteoarthritis. MATERIAL/PATIENTS AND METHODS: This is a descriptive prospective study over a period of three months on knee osteoarthritis outpatients. Demographic and clinical data were collected. An evaluation by a specific quality of life instrument for osteoarthritis of the knee: "The scale of Osteoarthritis of the Lower Limbs and Quality of Life (OAKHQOL)" Version 2...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27642238/plasma-leptin-is-elevated-in-acute-exacerbation-of-idiopathic-pulmonary-fibrosis
#14
Mengshu Cao, Jeffery J Swigris, Xin Wang, Min Cao, Yuying Qiu, Mei Huang, Yonglong Xiao, Hourong Cai
Background. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. Some patients will experience acute exacerbation (AE) and fatal outcomes. Methods. The study included 30 AE-IPF patients, 32 stable IPF (S-IPF) patients, and 12 healthy controls. We measured the plasma concentrations of leptin and KL-6. Simple correlation was used to assess associations between leptin and other variables. Plasma leptin levels were compared between AE-IPF and S-IPF subjects, decedents, and survivors...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27588444/clinical-analysis-and-outcome-of-interstitial-lung-disease-complicated-with-juvenile-dermatomyositis-and-juvenile-polymyositis
#15
Satoshi Sato, Yoji Uejima, Meika Nanbu, Eisuke Suganuma, Tadamasa Takano, Risa Tanaka, Tomoyuki Kabuki, Eiji Oguma, Tsutomu Oh-Ishi, Yutaka Kawano
OBJECTIVES: The aim of this study was to determine the clinical phenotype and outcome of interstitial lung disease (ILD) complicated with juvenile dermatomyositis (JDM) or juvenile polymyositis (JPM). METHODS: This was a single-center retrospective study. From 1984 to 2015, we retrospectively reviewed 29 patients who were diagnosed with JDM/JPM, among whom eight cases were ILD and 21 were non-ILD. The clinical features and laboratory findings included chest computed tomography (CT) images that were compared between the patients with ILD and non-ILD...
September 20, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27580939/nephrotoxicity-of-kalach-360-sl-biochemical-and-histopathological-findings
#16
Latifa Hamdaoui, Manel Naifar, Massara Mzid, Maryem Ben Salem, Amel Chtourou, Fatma Ayedi, Zouhaier Sahnoun, Tarek Rebai
Kalach 360 SL (KL) is a commercial herbicide which contains 360 g/l of Glyphosate used in both agricultural and urban areas throughout the world including Tunisia. We aimed to evaluate the effects of KL on rats' renal system. Female Wistar rats were divided into three groups: group 1 (n = 6) received a standard diet and served as control, groups 2 and 3 (n = 12 each) received 0.07ml (D1: 126 mg/Kg) and 0.175ml (D2: 315mg/Kg) of KL respectively, for 60 days. The chronic exposure to KL induced a significant increase in plasma creatinine, urea and uric acid levels...
September 1, 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27546601/effect-of-perioperative-pirfenidone-treatment-in-lung-cancer-patients-with-idiopathic-pulmonary-fibrosis
#17
Takekazu Iwata, Shigetoshi Yoshida, Taiki Fujiwara, Hironobu Wada, Takahiro Nakajima, Hidemi Suzuki, Ichiro Yoshino
BACKGROUND: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a life-threatening complication of lung cancer operation for patients with IPF, and no effective prophylaxis has ever been reported. In this study, we investigate the effect of perioperative treatment with an anti-IPF agent on reduction of the risk of developing AE-IPF. METHODS: A consecutive series of 50 lung cancer patients with IPF who underwent operations at our institution from October 2006 to October 2014 was retrospectively investigated...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27539862/arthroscopic-validation-of-radiographic-minimum-joint-space-width-associated-with-the-subchondral-bone-exposure-in-symptomatic-hip-dysplasia
#18
Yasuharu Nakashima, Masanori Fujii, Yasuo Noguchi, Kenya Suenaga, Takuaki Yamamoto, Jun-Ichi Fukushi, Goro Motomura, Satoshi Hamai, Daisuke Hara, Yukihide Iwamoto
OBJECTIVE: The purpose of this study was to clarify the minimum joint space width (MJSW) that leads to subchondral bone exposure (SBE) in patients with hip dysplasia. METHODS: We included 82 subjects (86 hips) who had hip dysplasia with center-edge angle less than 20° and who underwent periacetabular osteotomy combined with hip arthroscopy. The acetabular and femoral cartilages were divided into the three regions: anterosuperior, superior, and posterosuperior; for each region, we analyzed the correlation between the incidence of SBE and the MJSW measured on plain radiographs...
August 19, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27538472/plasma-plasmin-%C3%AE-2-plasmin-inhibitor-complex-levels-may-predict-the-effect-of-cyclophosphamide-for-systemic-sclerosis-related-interstitial-lung-disease
#19
Ryosuke Saigusa, Yoshihide Asano, Kouki Nakamura, Takashi Yamashita, Yohei Ichimura, Takehiro Takahashi, Tetsuo Toyama, Takashi Taniguchi, Ayumi Yoshizaki, Miki Miyazaki, Zenshiro Tamaki, Shinichi Sato
OBJECTIVES: Intravenous pulse cyclophosphamide (IVCY) is the first-line treatment for systemic sclerosis-associated interstitial lung disease (SSc-ILD). So far, there is no useful predictive marker for IVCY efficacy against SSc-ILD, although potential candidates are parameters reflecting vascular activation. Since plasma levels of plasmin-α2-plasmin inhibitor complex (PIC) serve as a potential biomarker of SSc vasculopathy, we evaluated the usefulness of plasma PIC levels as an indicator for IVCY efficacy against SSc-ILD...
August 19, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27515028/prognostic-significance-of-preoperative-serum-krebs-von-den-lungen-6-level-in-non-small-cell-lung-cancer
#20
Masaki Tomita, Takanori Ayabe, Eiichi Chosa, Naohiro Nose, Kunihide Nakamura
OBJECTIVES: We retrospectively analyzed the prognostic significance of preoperative serum Krebs von den Lungen-6 (KL-6) level in non-small cell lung cancer (NSCLC) patients. METHODS: We enrolled 175 NSCLC patients who underwent curative surgery between 2009 and 2011. We subdivided the patients into 2 groups: with and without interstitial lung disease (ILD). Prognostic significance of serum KL-6 level was examined. RESULTS: The 5-year survival of patients with high serum KL-6 level was poor...
November 2016: General Thoracic and Cardiovascular Surgery
keyword
keyword
112439
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"