keyword
MENU ▼
Read by QxMD icon Read
search

KL 6

keyword
https://www.readbyqxmd.com/read/28433814/synovial-fluid-pro-inflammatory-profile-differs-according-to-the-characteristics-of-knee-pain
#1
Ying Ying Leung, Janet L Huebner, Benjamin Haaland, Steven Bak Siew Wong, Virginia Byers Kraus
OBJECTIVE: The role of inflammation and pain in osteoarthritis (OA) is not fully understood. We evaluated the association between pro-inflammatory biomarkers and pain. METHODS: We used baseline data and samples from a randomized controlled trial of colchicine for symptomatic knee OA. Severity of pain of the more symptomatic knee was assessed by NHANES-I criterion and WOMAC pain index. Pains on movement and at rest were self-reported on an 11-point Likert scale. Severity of radiographic tibiofemoral OA was assessed by Kellgren and Lawrence (KL) grade...
April 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28425256/predictive-values-of-plasma-kl-6-in-bronchopulmonary-dysplasia-in-preterm-infants
#2
Dilek Dilli, Ahmet Özyazici, Arzu Dursun, Serdar Beken
BACKGROUND/AIM: It has been suggested that plasma KL-6 increases in premature infants with bronchopulmonary dysplasia (BPD). We aimed to evaluate the predictive values of KL-6 in BPD. MATERIALS AND METHODS: The study was performed in preterm neonates with birthweight ≤1500 g and gestational age ≤32 weeks. Plasma KL-6 levels were measured on postnatal days 1, 7, and 14. RESULTS: BPD was identified in eight of the 28 study infants. On postnatal days 1 and 7, plasma KL-6 levels were similar in infants with BPD [on day 1: 8...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28405350/quantifying-the-energy-stores-of-capital-breeding-humpback-whales-and-income-breeding-sperm-whales-using-historical-whaling-records
#3
Lyn G Irvine, Michele Thums, Christine E Hanson, Clive R McMahon, Mark A Hindell
Cetacean energy stores are known to vary according to life history, reproductive status and time of year; however, the opportunity to quantify these relationships is rare. Using a unique set of historical whaling records from Western Australia (1952-1963), we investigated energy stores of large cetaceans with differing life histories, and quantified the relationship between total body lipid and length for humpback whales (Megaptera novaeangliae) (n = 905) and sperm whales (Physeter macrocephalus) (n = 1961)...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28403862/muc1-in-lung-adenocarcinoma-cross-sectional-genetic-and-serological-study
#4
Yasushi Horimasu, Nobuhisa Ishikawa, Sonosuke Tanaka, Chihiro Hirano, Hiroshi Iwamoto, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori, Nobuoki Kohno
BACKGROUND: Mucin 1 (MUC1) contributes to the growth and metastasis of various cancers, including lung cancer, and MUC1 gene length polymorphisms are associated with susceptibility to lung cancer and its prognosis. In contrast, the association between rs4072037, a single nucleotide polymorphism in MUC1, and lung cancer has not been well studied. METHODS: In the present study, we determined the rs4072037 genotype and measured serum KL-6 levels to evaluate the association between lung adenocarcinoma (ADC) and rs4072037 or serum KL-6 levels...
April 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28400059/maximum-standardised-uptake-value-of-quantitative-bone-spect-ct-in-patients-with-medial-compartment-osteoarthritis-of-the-knee
#5
J Kim, H-H Lee, Y Kang, T K Kim, S W Lee, Y So, W W Lee
AIM: To evaluate the correlation between the maximum standardised uptake value (SUVmax) from bone single-photon-emission computed tomography/computed tomography (SPECT/CT) and other imaging parameters for medial compartment osteoarthritis (OA) of the knee. MATERIALS AND METHODS: Patients (n=26; male:female=2:24; age, 55.3±5.8 years) underwent quantitative knee SPECT/CT using technetium-99m (Tc-99m) hydroxymethylene diphosphonate (HDP) before surgical operation for medial OA of the knee...
April 8, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28382550/sitting-position-affects-performance-in-cross-country-sit-skiing
#6
M Lund Ohlsson, M S Laaksonen
PURPOSE: In cross-country sit-skiing (XCSS), athletes with reduced trunk control predominantly sit with the knees higher than the hips (KH); a position often associated with large spinal flexion. Therefore, to improve spinal curvature a new sledge with frontal trunk support, where knees are lower than hips (KL) was created. It was hypothesized that the KL position would improve respiratory function and enhance performance in seated double-poling compared to KH. METHODS: Ten female able-bodied cross-country skiers (age 25...
April 5, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28370220/impact-of-anti-tumor-necrosis-factor-%C3%AE-agents-on-serum-levels-of-kl-6-and-surfactant-protein-d-in-patients-with-psoriasis
#7
Mitsuha Hayashi, Koichi Yanaba, Yoshinori Umezawa, Akihiko Asahina, Hidemi Nakagawa
We longitudinally examined the influence of anti-tumor necrosis factor (TNF)-α treatment on serum levels of KL-6 and surfactant protein-D (SP-D). The study group comprised 22 patients with psoriasis treated with infliximab or adalimumab and with no history of interstitial lung disease (ILD). KL-6 and SP-D levels were measured in serum samples. Twelve of the 22 patients (55%) showed at least a 20% increase in KL-6 levels compared with baseline. Of these 12 patients, none exhibited any signs of ILD on chest computed tomography and nine who showed an increase in KL-6 levels (75%) showed at least a 20% increase in SP-D levels...
March 31, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28365812/serum-levels-of-matrix-metalloproteinase-3-and-autoantibodies-related-to-rheumatoid-arthritis-in-the-general-japanese-population-and-their-association-with-osteoporosis-and-osteoarthritis-the-road-study
#8
Rie Kodama, Shigeyuki Muraki, Toshiko Iidaka, Hiroyuki Oka, Masatoshi Teraguchi, Ryohei Kagotani, Yoshiki Asai, Hiroshi Hashizume, Munehito Yoshida, Hiroshi Kawaguchi, Kozo Nakamura, Toru Akune, Sakae Tanaka, Noriko Yoshimura
To purpose of this study was to reveal the mean levels and positive proportion of serological markers related to rheumatoid arthritis, and clarify their relationship with osteoporosis and hand osteoarthritis (OA). A total of 1546 participants from the third survey of the research on osteoarthritis/osteoporosis against disability study were enrolled in the current study. Using participant blood samples, the levels of anti-cyclic citrullinated protein (CCP) antibody, rheumatoid factor (RF), matrix metalloproteinase-3 (MMP-3), C-reactive protein (CRP), and high-sensitivity CRP (hsCRP) were measured...
April 1, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28365171/midterm-clinical-outcomes-and-mr-imaging-changes-after-transcatheter-arterial-embolization-as-a-treatment-for-mild-to-moderate-radiographic-knee-osteoarthritis-resistant-to-conservative-treatment
#9
Yuji Okuno, Amine M Korchi, Takuma Shinjo, Shojiro Kato, Takao Kaneko
PURPOSE: To describe the safety and efficacy of transcatheter arterial embolization for mild to moderate radiographic knee osteoarthritis (OA) that is resistant to conservative treatment. MATERIALS AND METHODS: This prospective study included 72 patients (95 knees) with OA of Kellgren-Lawrence (KL) grade 1-3 and persisting moderate to severe pain that was resistant to conservative management who were treated with transcatheter arterial embolization between July 2012 and March 2016...
March 29, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28361909/rational-mutagenesis-by-engineering-disulphide-bonds-improves-kluyveromyces-lactis-beta-galactosidase-for-high-temperature-industrial-applications
#10
Agustín Rico-Díaz, María-Efigenia Álvarez-Cao, Juan-José Escuder-Rodríguez, María-Isabel González-Siso, M Esperanza Cerdán, Manuel Becerra
Kluyveromyces lactis β-galactosidase (Kl-β-Gal) is one of the most important enzymes in the dairy industry. The poor stability of this enzyme limits its use in the synthesis of galactooligosaccharides (GOS) and other applications requiring high operational temperature. To obtain thermoresistant variants, a rational mutagenesis strategy by introducing disulphide bonds in the interface between the enzyme subunits was used. Two improved mutants, R116C/T270C and R116C/T270C/G818C, had increased half-lives at 45 °C compared to Kl-β-Gal (2...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28357100/interstitial-lung-disease-associated-with-trastuzumab-monotherapy-a-report-of-3-cases
#11
Akinori Sugaya, Shingo Ishiguro, Shoichi Mitsuhashi, Masahiro Abe, Ikuta Hashimoto, Takayuki Kaburagi, Hiroshi Kojima
We herein report 3 cases of female patients with breast cancer who developed interstitial lung disease (ILD) during trastuzumab monotherapy in an adjuvant setting. Prior chemotherapy included 4 cycles of epirubicin and cyclophosphamide in patients 1 and 2, and 4 cycles of docetaxel, cyclophosphamide and trastuzumab in patient 3. Patient 1 presented with a cough and fever after the fourth cycle of trastuzumab. Patient 2 experienced rapid deterioration of oxygen saturation without subjective symptoms within 3 h of the first administration of trastuzumab...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28356169/the-kl24-gene-cluster-and-a-genomic-island-encoding-a-wzy-polymerase-contribute-genes-needed-for-synthesis-of-the-k24-capsular-polysaccharide-by-the-multiply-antibiotic-resistant-acinetobacter-baumannii-isolate-rch51
#12
Johanna J Kenyon, Anastasiya A Kasimova, Mikhail M Shneider, Alexander S Shashkov, Nikolay P Arbatsky, Anastasiya V Popova, Konstantin A Miroshnikov, Ruth M Hall, Yuriy A Knirel
The whole-genome sequence of the multiply antibiotic resistant Acinetobacter baumannii isolate RCH51 belonging to sequence type ST103 (Institut Pasteur scheme) revealed that the set of genes at the capsule locus, KL24, includes four genes predicted to direct the synthesis of 3-acetamido-3,6-dideoxy-d-galactose (d-Fuc3NAc), and this sugar was found in the capsular polysaccharide (CPS). One of these genes, fdtE, encodes a novel bifunctional protein with an N-terminal FdtA 3,4-ketoisomerase domain and a C-terminal acetyltransferase domain...
March 2017: Microbiology
https://www.readbyqxmd.com/read/28355256/the-usefulness-of-monomeric-periostin-as-a-biomarker-for-idiopathic-pulmonary-fibrosis
#13
Shoichiro Ohta, Masaki Okamoto, Kiminori Fujimoto, Noriho Sakamoto, Koichiro Takahashi, Hiroshi Yamamoto, Hisako Kushima, Hiroshi Ishii, Keiichi Akasaka, Junya Ono, Ayami Kamei, Yoshinori Azuma, Hisako Matsumoto, Yukie Yamaguchi, Michiko Aihara, Takeshi Johkoh, Atsushi Kawaguchi, Masao Ichiki, Hironori Sagara, Jun-Ichi Kadota, Masayuki Hanaoka, Shin-Ichiro Hayashi, Shigeru Kohno, Tomoaki Hoshino, Kenji Izuhara
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was to use monomeric periostin in a multicenter study to evaluate its efficacy in diagnosing IPF and predicting its progression. To do so, we developed a new periostin kit to detect only monomeric periostin. The subjects consisted of 60 IPF patients in a multicenter cohort study...
2017: PloS One
https://www.readbyqxmd.com/read/28350195/standard-sampling-microdialysis-and-spreading-depolarizations-in-patients-with-malignant-hemispheric-stroke
#14
Alexandra Pinczolits, Anna Zdunczyk, Nora F Dengler, Nils Hecht, Christina M Kowoll, Christian Dohmen, Rudolf Graf, Maren Kl Winkler, Sebastian Major, Jed A Hartings, Jens P Dreier, Peter Vajkoczy, Johannes Woitzik
Spreading depolarizations (SD) occur in high frequency in patients with malignant hemispheric stroke (MHS). Experimentally, SDs cause marked increases in glutamate and lactate, whereas glucose decreases. Here, we studied extracellular brain glutamate, glucose, lactate, pyruvate and the lactate/pyruvate ratio in relationship to SDs after MHS. We inserted two microdialysis probes in peri-infarct tissue at 5 and 15 mm to the infarct in close proximity to a subdural electrode strip. During 2356.6 monitoring hours, electrocorticography (ECoG) revealed 697 SDs in 16 of 18 patients...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28332341/risk-factors-for-acute-exacerbation-of-idiopathic-pulmonary-fibrosis-a-systematic-review-and-meta-analysis
#15
Meihua Qiu, Yuqing Chen, Qiao Ye
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic andprogressive fibrotic disease limited to the lungs.The course of disease varies widely, with some patients experiencing acute respiratory deterioration, a conditioncalled acute exacerbations of IPF (AE-IPF). The risk factors contributing to AE-IPF are unclear. This systematic review and meta-analysis investigatedthe risk factors for AE-IPF. METHODS: Studies ofrisk factors for AE-IPF were identified in Medline, EMBASE and Cochrane databases...
March 23, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28331156/neonatal-high-permeability-pulmonary-edema-based-on-serial-cytokine-profiles-and-kl-6-in-serum-case-report
#16
Toshihiko Nakamura, Mari Nakamura, Naoto Takahashi
A newborn male with pulmonary edema was delivered at term by elective Caesarian section. Cytokine profiles of 17 cytokines and KL-6 in cord blood and serial serum values were investigated. The cord blood values of all 17 cytokines and KL-6 were within normal limits. Subsequently, IL-6, IL-8, IL-10, IL-13, IL-17, and IFNγ rapidly elevated during the first several hours after birth and dramatically decreased thereafter, whereas KL-6 rose to 611 U/ml on the 3(rd) day of life and then gradually decreased. These cytokines may induce pulmonary permeability, and KL-6 secreted in lining fluid could result in influx into the bloodstream...
March 22, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28330215/bioremediation-of-high-strength-agricultural-wastewater-using-ochrobactrum-sp-strain-sz1
#17
Chin Hong Neoh, Chi Yong Lam, Suriati Mat Ghani, Ismail Ware, Siti Hajar Mat Sarip, Zaharah Ibrahim
The biggest agricultural sector that contributes to the Malaysian economy is the oil palm industry. The effluent generated during the production of crude palm oil known as palm oil mill effluent (POME). POME undergoes anaerobic treatment that requires long retention time and produces large amount of methane that consequently contributes to global warming. In this study, an isolated bacteria was selected based on its ability to degrade kraft lignin (KL) and identified as Ochrobactrum sp. The bacteria were able to treat POME (from anaerobic pond) under the aerobic condition without addition of nutrient, resulting in a significant chemical oxygen demand (COD) removal of 71 %, removal rate of 1385 mg/l/day, and 12...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28275485/serum-kl-6-and-surfactant-protein-d-as-monitoring-and-predictive-markers-of-interstitial-lung-disease-in-patients-with-systemic-sclerosis-and-mixed-connective-tissue-disease
#18
Hideaki Yamakawa, Eri Hagiwara, Hideya Kitamura, Yumie Yamanaka, Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Koji Okudela, Tae Iwasawa, Tamiko Takemura, Kazuyoshi Kuwano, Takashi Ogura
BACKGROUND: Interstitial lung disease (ILD) is frequent complication of systemic sclerosis (SSc) and mixed connective tissue disease (MCTD). The disease is heterogeneous, and its outcome is unpredictable. Some patients have severe and progressive deterioration of ILD, which is the leading cause of mortality. We aimed to determine whether serum levels of Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) correlate with SSc/MCTD-associated ILD activity. METHODS: We retrospectively analyzed the medical records of 40 patients with SSc/MCTD-associated ILD: 29 patients with SSc and 11 patients with MCTD...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28275476/serum-kl-6-in-pulmonary-alveolar-proteinosis-china-compared-historically-with-germany-and-japan
#19
Wen-Liang Guo, Zi-Qing Zhou, Lu Chen, Zhu-Quan Su, Chang-Hao Zhong, Yu Chen, Shi-Yue Li
BACKGROUND: KL-6 is a biomarker of the severity of pulmonary alveolar proteinosis (PAP). We noticed a significant difference in the mean serum KL-6 level between Japanese and Caucasian patients. To assess the clinical value of serum KL-6 in Chinese PAP patients, and to compare the differences in serum KL-6 levels in Chinese patients and patients of other ethnicities. METHODS: From 2014-2016, we prospectively examined 37 Chinese Han patients with PAP, measured their serum KL-6 levels, evaluated the correlation between initial KL-6 levels and clinical variables, and compared our results with studies from Japan and Germany (similar methods were used)...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28272928/prospective-clinical-and-radiographic-outcomes-after-concomitant-anterior-cruciate-ligament-reconstruction-and-meniscal-allograft-transplantation-at-a-mean-5-year-follow-up
#20
Bryan M Saltzman, Maximilian A Meyer, Alexander E Weber, Sarah G Poland, Adam B Yanke, Brian J Cole
BACKGROUND: Concomitant anterior cruciate ligament reconstruction and meniscal allograft transplantation (ACLR/MAT) has demonstrated short-term success in small, retrospective cohort studies. Patient- and disease-specific predictors of success after ACLR/MAT are largely unknown. PURPOSE: To (1) prospectively evaluate the subjective and objective clinical and radiographic outcomes after ACLR/MAT and (2) conduct a subgroup analysis to identify patient- or disease-related factors that correlate with failure...
March 2017: American Journal of Sports Medicine
keyword
keyword
112439
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"