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https://www.readbyqxmd.com/read/29769460/circulating-surfactant-protein-d-is-associated-with-clinical-outcomes-in-peripheral-artery-disease-patients-following-endovascular-therapy
#1
Yoichiro Otaki, Tetsu Watanabe, Hiroki Takahashi, Takayuki Sugai, Miyuki Yokoyama, Satoshi Nishiyama, Takanori Arimoto, Tetsuro Shishido, Takuya Miyamoto, Tamon Yamanaka, Isao Kubota, Masafumi Watanabe
BACKGROUND: Peripheral artery disease (PAD) is a risk factor for the development of cardiovascular disease and death. Surfactant protein-D (SP-D) is a 43-kDa protein secreted from type II pneumocytes in the lungs. Recent studies have demonstrated that circulating SP-D plays a key role in the development of atherosclerosis and is related to clinical outcomes in patients with ischemic heart disease. However, it remains unclear whether circulating SP-D is associated with clinical outcomes in patients with PAD...
May 17, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29738932/sidestream-superoxygenation-for-wastewater-treatment-oxygen-transfer-in-clean-water-and-mixed-liquor
#2
Carlos M Barreto, Ivania M Ochoa, Hector A Garcia, Christine M Hooijmans, Dennis Livingston, Aridai Herrera, Damir Brdjanovic
The performance of a pilot-scale superoxygenation system was evaluated in clean water and mixed liquor. A mass balance was applied over the pilot-scale system to determine the overall oxygen mass transfer rate coefficient (KL a, h-1 ), the standard oxygen transfer rate (SOTR, kg O2 d-1 ), and the standard oxygen transfer efficiency (SOTE, %). Additionally, the alpha factor (α) was determined at a mixed liquor suspend solids (MLSS) concentration of approximately 5 g L-1 . SOTEs of nearly 100% were obtained in clean water and mixed liquor...
May 5, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29737065/-clinical-application-assessment-of-karyolite-bobs-combined-with-qf-pcr-in-the-detection-of-products-of-conception
#3
Hang Su, Hong-Mei Zhu, Ling-Ping Li, Ze Du, Yang Zeng, Ting Hu, Zhu Zhang, Shan-Ling Liu, He Wang
OBJECTIVE: To assess the accuracy and discuss the feasibility of KaryoLite bacterial artificial chromosome on beads (KL-BoBs) and quantitative fluorescent polymerase chain reaction (QF-PCR) in genetic testing of products of conception (POC) by comparing with the chromosomal microarray analysis (CMA) test results. METHODS: Eighty-one cases of abortion samples were collected in the prenatal diagnosis center of West China Second University Hospital in Sichuan University from May to August 2016,including 61 cases of placenta tissues,19 cases of fetal muscle tissues and 1 case of fetal liver tissue...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29728929/running-does-not-increase-symptoms-or-structural-progression-in-people-with-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#4
Grace H Lo, Sarra M Musa, Jeffrey B Driban, Andrea M Kriska, Timothy E McAlindon, Richard B Souza, Nancy J Petersen, Kristi L Storti, Charles B Eaton, Marc C Hochberg, Rebecca D Jackson, C Kent Kwoh, Michael C Nevitt, Maria E Suarez-Almazor
Higher levels of moderate to vigorous physical activity improve all-cause mortality and cardiovascular events. However, the effect of running, a moderate to vigorous activity, in those with knee osteoarthritis (OA), a common arthritis that occurs with aging, a high-risk group for mortality and cardiovascular events, is unclear. Therefore, we aimed to evaluate the association of self-selected running on OA symptom and structure progression in people with knee OA. This nested cohort study within the Osteoarthritis Initiative (OAI) (2004-2014) included those at least 50 years old with OA in at least one knee...
May 4, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29726283/lactobacillus-plantarum-is-10506-activates-intestinal-stem-cells-in-a-rodent-model
#5
A F Athiyyah, A Darma, R Ranuh, W Riawan, A Endaryanto, F A Rantam, I S Surono, S M Sudarmo
This study investigated the probiotic effect of Lactobacillus plantarum IS-10506 in activating and regenerating leucine-rich repeat-containing G-protein-coupled receptor (Lgr)5- and B lymphoma Moloney murine leukaemia virus insertion region (Bmi)1-expressing intestinal stem cells in rodents following Escherichia coli serotype 055:B5 lipopolysaccharide (LPS) exposure. Male Sprague-Dawley rats (n=64) were randomised into control (KN), LPS (KL), probiotic + LPS (KL-Pr), and sequential probiotic + LPS + probiotic (KPR-7L) groups...
May 4, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29712948/g-395a-polymorphism-in-the-promoter-region-of-the-klotho-gene-associates-with-frailty-among-the-oldest-old
#6
Qiukui Hao, Yuting Wang, Xiang Ding, Biao Dong, Ming Yang, Birong Dong, Yuquan Wei
Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a cohort of Chinese nonagenarians and centenarians for our study. This study is part of a cross-sectional study and secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study, which was conducted in Southwest China...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679131/process-optimization-involving-critical-evaluation-of-oxygen-transfer-oxygen-uptake-and-nitrogen-limitation-for-enhanced-biomass-and-lipid-production-by-oleaginous-yeast-for-biofuel-application
#7
Jayita Chopra, Ramkrishna Sen
Lipid accumulation in oleaginous yeast is generally induced by nitrogen starvation, while oxygen saturation can influence biomass growth. Systematic shake flask studies that help in identifying the right nitrogen source and relate its uptake kinetics to lipid biosynthesis under varying oxygen saturation conditions are very essential for addressing the bioprocessing-related issues, which are envisaged to occur in the fermenter scale production. In the present study, lipid bioaccumulation by P. guilliermondii at varying C:N ratios and oxygen transfer conditions (assessed in terms of kL a) was investigated in shake flasks using a pre-optimized N-source and a two-stage inoculum formulated in a hybrid medium...
April 20, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29674428/optimising-endocrine-therapy-in-postmenopausal-women-with-advanced-breast-cancer
#8
Thomas Ho Lai Yau, Kl Cheung
Hormone receptor-positive breast cancer is commonly treated with endocrine therapy; however, overtime cancer cells can develop endocrine resistance. This review aims to document combination therapy and sequential therapy in the use of endocrine agents and targeted agents. By conducting two systematic searches using 4 databases: Cochrane Library, MEDLINE, EMBASE, and Web of Science. A total of 26 studies that covered combination therapy were obtained and included for the review. 14 were phase III documenting combinations of mechanistic target of rapamycin (mTOR), phosphoinositide-3-kinase (PI3K), vascular endothelial growth factor receptor (VEGFR), human epidermal growth factor receptor 2 (HER2), and cyclin dependent kinase 4/6 (CDK4/6) inhibitors...
April 19, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29669483/study-of-lung-toxicity-in-rats-exposed-to-silica-powder-with-different-hard-metal-constituents
#9
Zhansai Zhang, Yanfang Zhao, Gang Chen, Ruoming Li, Jun Yang, Daoyuan Sun
The objective of this study was to assess the lung toxicity induced by the inhalation of different hard metal constituents and silica powder and screen for potential toxicity biomarkers. Rats were randomly divided into saline, cobalt, tungsten carbide, silica, and hard metal (HM) groups and were administered a single 10-mg dose of the respective treatments. After 8 weeks, the lung tissue structure in the HM group was deformed, numerous nucleated giant and epithelial-like cells appeared in the stroma, and the computed tomography scanning images appeared abnormal...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29665388/expression-and-characterization-of-novel-laccase-gene-from-pandoraea-sp-istkb-and-its-application
#10
Madan Kumar, Arti Mishra, Shashi Shekhar Singh, Shaili Srivastava, Indu Shekhar Thakur
In the present study, a non-blue laccase gene from previously reported lignin degrading bacterium, Pandoraea sp. ISTKB, was isolated, cloned and expressed in E. coli. Bioinformatics analysis of sequence discovered twin-arginine translocation signal sequence, copper binding motifs and presence of more random coil compare to helices and sheets in structure. The enzyme was found to be active on wide pH range and the pH optima was observed at pH 4 and 8 on substrate 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and 2,6-Dimethoxyphenol respectively...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29648685/association-of-physical-examination-knee-effusion-with-bone-marrow-lesions-cross-sectional-and-longitudinal-analyses-of-a-population-based-cohort
#11
Jolanda Cibere, Ali Guermazi, Savvas Nicolaou, John M Esdaile, Anona Thorne, Joel Singer, Hubert Wong, Jacek A Kopec, Eric C Sayre
OBJECTIVE: To determine the association of physical examination (PE) effusion with prevalence of bone marrow lesions (BML) on MRI, and incidence/progression of BML over 3 years in knee osteoarthritis (OA). METHODS: A population-based cohort with knee pain (N=255) was assessed for PE effusion. On MRI, BML was graded 0-3 (none, mild, moderate, severe), incidence/progression defined as a worsening in the sum of BML scores over six surfaces by ≥1 grade. We analyzed the full cohort and mild disease subsample with Kellgren-Lawrence (KL) grade <3...
April 12, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29627482/assessment-of-statin-induced-interstitial-pneumonia-in-patients-treated-for-hyperlipidemia-using-a-health-insurance-claims-database-in-japan
#12
Kenji Momo, Akiko Takagi, Atsuko Miyaji, Masayoshi Koinuma
PURPOSE: This study aimed to determine the frequency and risk factors for statin-induced interstitial pneumonia (IP). METHOD: We conducted a retrospective cohort study using a large Japanese health insurance claims database. We determined the statin-induced IP incidence in patients treated with statins for hyperlipidemia (n = 194,814) with 12-month screening and 3-month observation periods. Statin-induced IP was defined as: (1) diagnosis with IP (ICD-10 codes: J70...
April 5, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29610629/digital-clubbing-is-associated-with-higher-serum-kl-6-levels-and-lower-pulmonary-function-in-patients-with-interstitial-lung-disease
#13
Kazushige Shiraishi, Torahiko Jinta, Naoki Nishimura, Hiroshi Nakaoka, Ryosuke Tsugitomi, Kohei Okafuji, Atsushi Kitamura, Yutaka Tomishima, Gautam A Deshpande, Tomohide Tamura
Background: Although digital clubbing is a common presentation in patients with interstitial lung disease (ILD), little has been reported regarding its role in assessing patients with ILD. This study evaluated patients with ILD for the presence of clubbing and investigated its association with clinical data. Methods: We evaluated patients with ILD who visited the teaching hospital at which the study was conducted, between October 2014 and January 2015. Clubbing, evaluated using a Vernier caliper for individual patients, was defined as a phalangeal depth ratio > 1...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29605779/a-systematic-comparison-of-two-empirical-gas-liquid-mass-transfer-determination-methodologies-to-characterize-methane-biodegradation-in-stirred-tank-bioreactors
#14
Raul Muñoz, Cenit Soto, Cristal Zuñiga, Sergio Revah
This study aimed at systematically comparing the potential of two empirical methods for the estimation of the volumetric CH4 mass transfer coefficient (kl aCH4 ), namely gassing-out and oxygen transfer rate (OTR), to describe CH4 biodegradation in a fermenter operated with a methanotrophic consortium at 400, 600 and 800 rpm. The kl aCH4 estimated from the OTR methodology accurately predicted the CH4 elimination capacity (EC) under CH4 mass transfer limiting conditions regardless of the stirring rate (∼9% of average error between empirical and estimated ECs)...
March 29, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29600055/clarithromycin-mitigates-radiation-pneumonitis-in-patients-with-lung-cancer-treated-with-stereotactic-body-radiotherapy
#15
Atsuya Takeda, Yuichiro Tsurugai, Naoko Sanuki, Tatsuji Enomoto, Masaharu Shinkai, Tomikazu Mizuno, Yousuke Aoki, Yohei Oku, Takeshi Akiba, Yu Hara, Etsuo Kunieda
Background: Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. Macrolides including clarithromycin (CAM) are antibiotics. They also have immunomodulatory properties and are used to treat respiratory inflammatory diseases. Radiation pneumonitis has similar pathology to them. Adverse reactions to macrolides are few and self-limited. We thus administered CAM to patients with high-risk factors for radiation pneumonitis, and retrospectively investigated whether CAM mitigated radiation pneumonitis following stereotactic body radiotherapy (SBRT)...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29595258/reductive-o-2-binding-at-a-dihydride-complex-leading-to-redox-interconvertible-%C3%AE-1-2-peroxo-and-%C3%AE-1-2-superoxo-dinickel-ii-intermediates
#16
Peng-Cheng Duan, Dennis-Helmut Manz, Sebastian Dechert, Serhiy Demeshko, Franc Meyer
Dioxygen activation at nickel complexes is much less studied than for the biologically more relevant iron or copper systems but promises new reactivity patterns because of the distinct coordination chemistry of nickel. Here we report that a pyrazolate-based dinickel(II) dihydride complex [KL(Ni-H)2 ] (1a) smoothly reacts with O2 via reductive H2 elimination to give the μ-1,2-peroxo dinickel(II) complex [KLNi2 (O2 )] (2a) and, after treatment with dibenzo[18]-crown-6, the separated ion pair [K(DB18C6)][LNi2 (O2 )] (2b); these are the first μ-1,2-peroxo dinickel intermediates to be characterized by X-ray diffraction...
March 29, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29562767/synovial-fluid-eotaxin-1-levels-may-reflect-disease-progression-in-primary-knee-osteoarthritis-among-elderly-han-chinese-a-cross-sectional-study
#17
Bei Li, Yi-Li Zhang, Shou-Yi Yu
Objective The CC chemokine family member eotaxin-1, also named chemokine C-C motif ligand 11 (CCL11), has been detected in knee osteoarthritis (OA) and could induce breakdown of cartilage matrix. This study was performed to investigate the plasma and synovial fluid eotaxin-1 levels with the disease progression in elderly Han Chinese with primary knee OA. Design A total of 143 elderly primary knee OA patients and 135 healthy controls were enrolled in the study. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was performed to evaluate the clinical severity...
March 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29544822/understanding-urban-water-performance-at-the-city-region-scale-using-an-urban-water-metabolism-evaluation-framework
#18
Marguerite A Renouf, Steven J Kenway, Ka Leung Lam, Tony Weber, Estelle Roux, Silvia Serrao-Neumann, Darryl Low Choy, Edward A Morgan
Water sensitive interventions are being promoted to reduce the adverse impacts of urban development on natural water cycles. However it is currently difficult to know the best strategy for their implementation because current and desired urban water performance is not well quantified. This is particularly at the city-region scale, which is important for strategic urban planning. This work aimed to fill this gap by quantifying the water performance of urban systems within city-regions using 'urban water metabolism' evaluation, to inform decisions about water sensitive interventions...
February 8, 2018: Water Research
https://www.readbyqxmd.com/read/29541466/diagnostic-usefulness-of-kl-6-concentration-of-bile-in-biliary-tract-cancer
#19
Takumi Onoyama, Kazuya Matsumoto, Hiroki Koda, Taro Yamashita, Hiroki Kurumi, Soichiro Kawata, Yohei Takeda, Kenichi Harada, Kazuo Yashima, Hajime Isomoto
The sensitivity of bile cytology for biliary tract cancer varies from 6-64%, and hence remains unsatisfactory. Sialylated carbohydrate antigen KL-6 mucin is positive in biliary tract cancer tissues and serum KL-6 levels are significantly increased in intrahepatic ductal adenocarcinoma patients compared with healthy individuals. The aim of the present study was to evaluate the usefulness of the KL-6 concentration of bile for the diagnosis of biliary tract cancer. Bile cytology and measurements of bile KL-6 concentration were conducted for 43 patients (25 biliary tract cancers and 18 benign biliary disease)...
April 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29491310/a-case-of-fulminant-type-1-diabetes-mellitus-accompanied-by-positive-conversion-of-anti-insulin-antibody-after-the-administration-of-anti-ctla-4-antibody-following-the-discontinuation-of-anti-pd-1-antibody
#20
Michiru Shiba, Hidefumi Inaba, Hiroyuki Ariyasu, Shintaro Kawai, Yuko Inagaki, Shohei Matsuno, Hiroshi Iwakura, Yuki Yamamoto, Masahiro Nishi, Takashi Akamizu
An 80-year-old woman with malignant melanoma received 20 cycles of anti-PD-1 antibody (nivolumab) treatment and showed normal glucose tolerance. Three weeks after switching to anti-CTLA-4 antibody (ipilimumab), her plasma glucose level was elevated to 639 mg/dL, her HbA1c was 7.7%, and her fastening serum CPR was undetectable. Anti-GAD and IA-2 antibodies were negative. She was diagnosed with fulminant type 1 diabetes mellitus (F1DM). Remarkably, her anti-insulin antibody was positively converted, and her KL-6 levels increased after ipilimumab therapy...
February 28, 2018: Internal Medicine
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