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https://www.readbyqxmd.com/read/28100307/the-kl24-gene-cluster-and-a-genomic-island-encoding-a-wzy-polymerase-contribute-genes-needed-for-synthesis-of-the-k24-capsular-polysaccharide-by-the-multiply-antibiotic-resistant-acinetobacter-baumannii-isolate-rch51
#1
Johanna J Kenyon, Anastasiya A Kasimova, Mikhail Shneider, Alexander S Shashkov, Nikolay P Arbatsky, Anastasiya V Popova, Konstantin A Miroshnikov, Ruth M Hall, Yuriy A Knirel
The whole genome sequence of the multiply antibiotic resistant Acinetobacter baumannii isolate RCH51 belonging to sequence type ST103 (Institut Pasteur scheme) revealed that the set of genes at the capsule locus, KL24, includes four genes predicted to direct the synthesis of 3-acetamido-3,6-dideoxy-D-galactose (D-Fuc3NAc) and this sugar was found in the capsular polysaccharide (CPS). One of these genes, fdtE, encodes a novel bifunctional protein with an N-terminal FdtA 3,4-ketoisomerase domain and a C-terminal acetyltransferase domain...
January 17, 2017: Microbiology
https://www.readbyqxmd.com/read/28031829/summer-type-hypersensitivity-pneumonitis-in-a-patient-with-rheumatoid-arthritis-on-methotrexate-and-tacrolimus
#2
Hirotsugu Ohkubo, Minami Okayama, Kensuke Fukumitsu, Akio Niimi
A 59-year-old woman receiving methotrexate and tacrolimus for rheumatoid arthritis (RA) was referred to our hospital following bilateral ground-glass opacity observed in her chest X-ray and elevated serum KL-6. After methotrexate and tacrolimus cessation, shortness of breath developed and ground-glass opacity observed in the chest computed tomography rapidly worsened. Bronchoalveolar lavage showed increased lymphocytes, and trans-bronchial lung biopsy confirmed lymphocytic alveolitis. In addition, the patient had serum antibodies against Trichosporon asahii, a fungal pathogen...
November 2016: Respirology Case Reports
https://www.readbyqxmd.com/read/28028271/-differential-diagnosis-of-interstitial-pneumonia-by-home-ultrasound-examination
#3
Keigo Yasukawa, Kazuhiro Hisajima, Kazutaka Imai, Yukihiro Soga
BACKGROUND: Patients receiving home care present clinically diverse forms of chronic respiratory failure, for which it is difficult to establish a definite diagnosis. CT diagnosis requires the patient to be transported, and obtaining the blood test results for the serum maker KL-6 requires a few days. Nevertheless, with the widespread use of portable ultrasound devices, we can now make an immediate ultrasound diagnosis of the lung in the home care setting. In our experience, most patients with deteriorated interstitialpneumonia show characteristic large disseminated B-lines or pleural effusion...
December 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28028160/predictive-value-of-mri-features-for-development-of-radiographic-osteoarthritis-in-a-cohort-of-participants-with-pre-radiographic-knee-osteoarthritis-the-check-study
#4
Kim van Oudenaarde, Björn Jobke, Ans C M Oostveen, Annekarien C A Marijnissen, Ron Wolterbeek, Janet Wesseling, Sita M A Bierma-Zeinstra, Hans L Bloem, Monique Reijnierse, Margreet Kloppenburg
OBJECTIVE: To determine whether MRI features are associated with development of radiographic knee OA and can be used as a predictive tool in early knee OA. METHODS: In 148 participants of the Cohort Hip and Cohort Knee study (mean age 56 years, 78% women), with a Kellgren Lawrence (KL) score ⩽1, we obtained semi-quantitatively scored knee MRI scans and radiographs at baseline. After 5 years, we determined the development of radiographic knee OA (KL ⩾2). We calculated odds ratios (ORs), with 95% CIs adjusted for age, sex and BMI, to identify MRI features associated with OA development...
January 2017: Rheumatology
https://www.readbyqxmd.com/read/28026113/prognostic-evaluation-by-oxygenation-with-positive-end-expiratory-pressure-in-acute-exacerbation-of-idiopathic-pulmonary-fibrosis-a-retrospective-cohort-study
#5
Atsushi Suzuki, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Tomoki Kimura, Kensuke Kataoka, Toshiaki Matsuda, Toshiki Yokoyama, Koji Sakamoto, Yoshinori Hasegawa
INTRODUCTION: Acute exacerbation (AE) is a severe complication of idiopathic pulmonary fibrosis (IPF), which shares some common pathological features with acute respiratory distress syndrome (ARDS). The new definition of ARDS requires positive end-expiratory pressure (PEEP) to assess gas exchange and has better predictive validity for short-term mortality compared with the previous definition. OBJECTIVES: The aim of this study was to evaluate the prognostic utility of oxygenation with PEEP in AE-IPF...
December 27, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28012490/association-of-anti-aminoacyl-transfer-rna-synthetase-antibody-and-anti-melanoma-differentiation-associated-gene-5-antibody-with-the-therapeutic-response-of-polymyositis-dermatomyositis-associated-interstitial-lung-disease
#6
Naomi Yoshida, Masaki Okamoto, Shinjiro Kaieda, Kiminori Fujimoto, Tomohiro Ebata, Morihiro Tajiri, Masayuki Nakamura, Masaki Tominaga, Daisuke Wakasugi, Tomotaka Kawayama, Masataka Kuwana, Tsuneyo Mimori, Hiroaki Ida, Tomoaki Hoshino
BACKGROUND: We attempted to clarify whether the presence of anti-aminoacyl-transfer RNA synthetase antibody (anti-ARS Ab) or anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) is associated with the therapeutic response of polymyositis/dermatomyositis-associated interstitial lung disease (PM/DM-ILD). METHODS: We retrospectively investigated 22 patients with PM/DM-ILD (10 positive for anti-ARS Ab and nine positive for anti-MDA5 Ab) for whom antibody analysis of conserved serum was possible...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28012488/prognostic-value-of-serial-serum-kl-6-measurements-in-patients-with-idiopathic-pulmonary-fibrosis
#7
Kentaro Wakamatsu, Nobuhiko Nagata, Hiroyuki Kumazoe, Keishi Oda, Hiroshi Ishimoto, Michihiro Yoshimi, Shohei Takata, Minako Hamada, Yoshifusa Koreeda, Kouji Takakura, Miwa Ishizu, Makiko Hara, Shinji Ise, Miiru Izumi, Takashi Akasaki, Sanae Maki, Masaharu Kawabata, Hiroshi Mukae, Masayuki Kawasaki
BACKGROUND: The prognostic significance of serial measurements of serum KL-6 levels in patients with idiopathic pulmonary fibrosis (IPF) is unclear; hence, it was assessed in this study. METHODS: Medical records of 66 patients with IPF, who were not treated with pirfenidone prior to enrollment, were retrospectively reviewed for information on clinical progress, forced vital capacity (FVC), survival, and serum KL-6 levels. We assessed initial serum levels of KL-6, serial changes in serum KL-6 levels, yearly decline in FVC (ΔFVC), and the rate of decline (%ΔFVC)...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/27943308/metabolic-injury-in-a-variable-rat-model-of-post-status-epilepticus
#8
Patrice S Pearce, Yijen Wu, Amedeo Rapuano, Kevin M Kelly, Nihal de Lanerolle, Jullie W Pan
OBJECTIVE: In vivo studies of epilepsy typically use prolonged status epilepticus to generate recurrent seizures. However, reports on variable status duration have found discrete differences in injury after 40-50 min of seizures, suggesting a pathophysiologic sensitivity to seizure duration. In this report we take a multivariate cluster analysis to study a short duration status epilepticus model using in vivo 7T magnetic resonance spectroscopy (MRS) and histologic evaluation. METHODS: The Hellier Dudek model was applied with 45 min of status epilepticus after which the animals were imaged twice, at 3 days and 3 weeks post-status epilepticus...
December 2016: Epilepsia
https://www.readbyqxmd.com/read/27941940/kefir-peptides-prevent-high-fructose-corn-syrup-induced-non-alcoholic-fatty-liver-disease-in-a-murine-model-by-modulation-of-inflammation-and-the-jak2-signaling-pathway
#9
H L Chen, T C Tsai, Y C Tsai, J W Liao, C C Yen, C M Chen
OBJECTIVE: In recent years, people have changed their eating habits, and high-fructose-containing bubble tea has become very popular. High-fructose intake has been suggested to be a key factor that induces non-alcoholic fatty liver disease (NAFLD). Kefir, a fermented milk product composed of microbial symbionts, has demonstrated numerous biological activities, including antibacterial, antioxidant and immunostimulating effects. The present study aims to evaluate the effects of kefir peptides on high-fructose-induced hepatic steatosis and the possible molecular mechanism...
December 12, 2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/27939621/the-relationship-between-foot-and-ankle-symptoms-and-risk-of%C3%A2-developing-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#10
K L Paterson, J Kasza, D J Hunter, R S Hinman, H B Menz, G Peat, K L Bennell
OBJECTIVE: To investigate whether foot and/or ankle symptoms increase the risk of developing (1) knee symptoms and (2) symptomatic radiographic knee osteoarthritis (OA). DESIGN: 1020 Osteoarthritis Initiative (OAI) participants who were at-risk of knee OA, but were without knee symptoms or radiographic knee OA, were investigated. Participants indicated the presence and laterality of foot/ankle symptoms at baseline. The main outcome was development of knee symptoms (pain, aching or stiffness in and around the knee on most days of the month for at least 1 month in the past year)...
December 7, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27938700/limited-evidence-suggested-that-unfinished-root-canal-treatments-may-increase-the-risk-of-cardiovascular-disease
#11
Waranuch Pitiphat
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Unfinished root canal treatments and the risk of cardiovascular disease. Lin PY, Chien KL, Chang HJ, Chi LY. J Endod 2015;41(12):1991-6. SOURCE OF FUNDING: The National Science Council in Taiwan (Government) TYPE OF STUDY/DESIGN: Retrospective cohort study.
December 2016: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/27919567/splicing-factor-proline-glutamine-rich-is-a-novel-autoantigen-of-dermatomyositis-and-associated-with-anti-melanoma-differentiation-associated-gene-5-antibody
#12
Yuji Hosono, Ran Nakashima, Satoshi Serada, Kosaku Murakami, Yoshitaka Imura, Hajime Yoshifuji, Koichiro Ohmura, Tetsuji Naka, Tsuneyo Mimori
OBJECTIVE: Anti-MDA5 antibody positive dermatomyositis (DM) and clinically amyopathic DM (CADM) often develop into rapidly progressive interstitial lung disease, but their pathogenesis remains unclear. We observed that sera from DM/CADM patients immunoprecipitated a common 110 kDa polypeptide. We investigated this autoantigen and its clinical significance. METHODS: Autoantibodies were screened in 333 patients with various connective tissue diseases (CTDs) and 20 healthy controls (HCs) by immunoprecipitation with [(35)S]methionine-labeled HeLa cells...
December 2, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27915458/acl-deficiency-and-varus-osteoarthritis-high-tibial-osteotomy-alone-or-combined-with-acl-reconstruction
#13
Julian Mehl, Jochen Paul, Matthias J Feucht, Gerrit Bode, Andreas B Imhoff, Norbert P Südkamp, Stefan Hinterwimmer
INTRODUCTION: This study investigates the mid- to long-term clinical and radiological outcome in patients with symptomatic varus osteoarthritis (OA) and deficiency of the anterior cruciate ligament (ACL) and analyzes whether there are differences between isolated high tibial osteotomy (HTO) or combined single-stage HTO and ACL reconstruction (ACLR). METHODS: 26 patients who underwent HTO alone (group 1) and 26 patients who underwent single-stage HTO and ACLR (group 2) because of varus OA and ACL deficiency were examined at a mean of 5...
December 3, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27909787/test-retest-reliability-of-tibiofemoral-joint-space-width-measurements-made-using-a-low-dose-standing-ct-scanner
#14
Neil A Segal, John Bergin, Andrew Kern, Christian Findlay, Donald D Anderson
OBJECTIVE: To determine the test-retest reliability of knee joint space width (JSW) measurements made using standing CT (SCT) imaging. SUBJECTS AND METHODS: This prospective two-visit study included 50 knees from 30 subjects (66% female; mean ± SD age 58.2 ± 11.3 years; BMI 29.1 ± 5.6 kg/m(2); 38% KL grade 0-1). Tibiofemoral geometry was obtained from bilateral, approximately 20° fixed-flexed SCT images acquired at visits 2 weeks apart. For each compartment, the total joint area was defined as the area with a JSW <10 mm...
February 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/27894935/stage-specific-differences-in-secretory-profile-of-mesenchymal-stromal-cells-mscs-subjected-to-early-vs%C3%A2-late-stage-oa-synovial-fluid
#15
A Gómez-Aristizábal, A Sharma, M A Bakooshli, M Kapoor, P M Gilbert, S Viswanathan, R Gandhi
OBJECTIVE: Although, mesenchymal stromal cells (MSCs) are being clinically investigated for their use in osteoarthritis (OA), it is unclear whether their postulated therapeutic properties are equally effective in the early- and late-stages of OA. In this study we investigated MSC cytokine secretion post-exposure to synovial fluid (SF), obtained from early- vs late-stage knee OA patients to justify a potential patient stratification strategy to maximize MSC-mediated treatment effects...
November 25, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27882773/the-acquisition-of-initial-consonant-clusters-in-german-speaking-2-year-olds
#16
Blanca Schaefer, Annette Fox-Boyer
PURPOSE: The aim of this study was to explore cluster acquisition in typically developing German-speaking 2-year-olds. METHOD: Data from four cross-sectional studies (n = 145, aged 2;00-2;11) and one eight-month longitudinal study were analysed (n = 6, aged 2;01-2;04). Two different percentages of consonant clusters correct were calculated to allow a more detailed analysis. RESULT: Findings showed that the majority of children produced clusters, although they could not be considered to be fully acquired...
November 24, 2016: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27861264/use-of-b-mode-ultrasound-as-a-body-fat-estimate-in-collegiate-football-players
#17
Parker N Hyde, Kristina L Kendall, Ciaran M Fairman, Nicholas A Coker, Mary E Yarbrough, Steve J Rossi
Hyde, PN, Kendall, KL, Fairman, CM, Coker, NA, Yarbrough, ME, and Rossi, SJ. Utilization of B-mode ultrasound as a body fat estimate in collegiate football players. J Strength Cond Res 30(12): 3525-3530, 2016-The purpose of the present study was to validate a 7-site ultrasound imaging protocol to predict the percent body fat (%BF) in a division I football team. Body composition was estimated by ultrasound, 7-site skinfolds, and the 3-compartment-water (3C-W) model of Siri, using bioimpedance spectroscopy to estimate the total body water and air displacement plethysmography (using BODPOD) to determine the body density...
December 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27852185/young-onset-colorectal-cancer-in-new-south-wales-a-population-based-study
#18
Stephen Boyce, Natasha Nassar, Cathy Yuen Yi Lee, Michael Kl Suen, Saleh Al Zahrani, Marc A Gladman
OBJECTIVE: Australia has the highest incidence of colorectal cancer (CRC) in the world. The incidence of young-onset CRC (yCRC) is increasing in developed nations. Our aim was to determine the incidence of yCRC in New South Wales, the demographic and clinico-pathological characteristics of these patients, and their survival. DESIGN, SETTING, PARTICIPANTS: A population-based cohort study of all cases of CRC diagnosed in NSW during 2001-2008. Data on newly diagnosed cases of CRC were obtained from the NSW Central Cancer Registry; mortality data were obtained from the NSW Registry of Births Deaths and Marriages (to 2012)...
November 21, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27835043/risk-factors-for-medial-tibial-stress-syndrome-in-active-individuals-an-evidence-based-review
#19
Zachary K Winkelmann, Dustin Anderson, Kenneth E Games, Lindsey E Eberman
: Reference/Citation: Hamstra-Wright KL, Bliven KC, Bay C. Risk factors for medial tibial stress syndrome in physically active individuals such as runners and military personnel: a systematic review and meta-analysis. Br J Sports Med. 2015;49(6)362-369. CLINICAL QUESTION:  What factors put physically active individuals at risk to develop medial tibial stress syndrome (MTSS)? DATA SOURCES:  The authors performed a literature search of CINAHL, the Cochrane Central Register of Controlled Trials, EMBASE, and MEDLINE from each database's inception to July 2013...
November 1, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27758986/the-value-of-biomarkers-as-predictors-of-outcome-in-patients-with-rheumatoid-arthritis-associated-usual-interstitial-pneumonia
#20
Young Seok Lee, Ho Cheol Kim, Bo Young Lee, Chang Keun Lee, Mi-Young Kim, Se Jin Jang, Hye Sun Lee, Jieun Moon, Thomas V Colby, Dong Soon Kim
BACKGROUND: Because of the highly variable clinical course of rheumatoid arthritis-associated usual interstitial pneumonia (RA-UIP), the prediction of patient prognosis is important. OBJECTIVE: The aim of this study was to investigate the role of blood biomarkers as prognostic predictors in the patients with RA-UIP. METHODS: The blood levels of biomarkers (Krebs von den Lungen-6 [KL-6], surfactant protein-A [SP-A], matrix metalloproteinase-7 [MMP-7], interleukin-6 [IL-6], and interleukin-32 [IL-32]) were retrospectively compared with the clinical courses of 62 patients with RA-UIP...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
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