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https://www.readbyqxmd.com/read/29785335/raised-vulvar-lesions-be-aware
#1
Fernanda S Resende, Claudio Conforti, Roberta Giuffrida, Mayara Hamilko de Barros, Iris Zalaudek
Vulvar melanoma is a rare and deadly cancer in women, and the prognosis is often poor. There are limited studies on the dermoscopic features of vulvar melanoma. Described criteria include the presence of blue, gray, or white colors. Herein we present the clinical and dermoscopic characteristics of a hypopigmented and heavily pigmented nodule in a 92-year-old and an 80-year-old woman. Dermoscopy in the former revealed structureless milky-red to white areas, remnants of brown pigmentation at the base and polymorphic vessels, while the latter displayed structureless blue-gray areas with black dots and peripheral lines at the base...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29785333/acral-lentiginous-melanoma-in-the-turkish-population-and-a-new-dermoscopic-clue-for-the-diagnosis
#2
Fezal Ozdemir, Micol A Errico, Banu Yaman, Isil Karaarslan
Background: The incidence of acral lentiginous melanoma (ALM) in the white population is low. Dermoscopy enhances diagnosis of ALM; however, diagnostic accuracy may sometimes be poor due to the considerable proportion of amelanotic ALM variants. Objectives: To calculate the proportion of ALM among all melanoma subtypes and to determine the frequency of dermoscopic features of ALM in the Turkish population. Methods: Out of 612 melanomas, there were 70 cases of ALM, of which 46 showed sufficient image quality for retrospective study of dermoscopic features...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29785330/dermoscopy-of-a-spark-s-nevus
#3
Giovanni Biondo, Matteo Gnone, Simona Sola, Carlotta Pastorino, Cesare Massone
Spark's nevus is a particular type of melanocytic nevus that on histology shows features of both Spitz's and Clark's nevus. Clinically, it is an asymmetric, irregular, multicolored, pigmented lesion that is not clearly distinguishable from melanoma or dysplastic (Clark's) nevus. Dermoscopic features have not been described yet, and one could speculate that they are similar to those of Clark's nevi because the histopathologic architecture of Spark's nevus is similar to that of a Clark's nevus, resembling Spitz's nevi in the epithelioid morphology of melanocytes...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#4
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29780659/confocal-microscopy-in-skin-cancer
#5
REVIEW
Verena Ahlgrimm-Siess, Martin Laimer, Harold S Rabinovitz, Margaret Oliviero, Rainer Hofmann-Wellenhof, Ashfaq A Marghoob, Alon Scope
Purpose of Review: Reflectance confocal microscopy (RCM) enables imaging of skin lesions at cellular level resolution at the bedside (in vivo) or in freshly excised tissue (ex vivo). This article provides an overview of strengths and limitations of non-invasive RCM in skin cancer diagnosis. Recent Findings: RCM features of common melanocytic and non-melanocytic skin neoplasms such as melanoma, actinic keratosis/squamous cell carcinoma, basal cell carcinoma, and nevi have been well defined and show good correlation with dermoscopic and histopathologic findings...
2018: Current Dermatology Reports
https://www.readbyqxmd.com/read/29732346/a-new-algorithm-for-skin-lesion-border-detection-in-dermoscopy-images
#6
E Meskini, M S Helfroush, K Kazemi, M Sepaskhah
Background: With advances in medical imaging systems, digital dermoscopy has become one of the major imaging modalities in the analysis of skin lesions. Thus, automated segmentation or border detection has a great impact on the subsequent steps of skin cancer computer-aided diagnosis using demoscopy images. Since dermoscopy images suffer from artifacts such as shading and hair, there is a need for automated and robust artifact attenuation removal and lesion border detection. Methods: method for segmentation of dermoscopy images is proposed based on active contour...
March 2018: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29689095/correction-acral-melanoma-detection-using-a-convolutional-neural-network-for-dermoscopy-images
#7
Chanki Yu, Sejung Yang, Wonoh Kim, Jinwoong Jung, Kee-Yang Chung, Sang Wook Lee, Byungho Oh
[This corrects the article DOI: 10.1371/journal.pone.0193321.].
2018: PloS One
https://www.readbyqxmd.com/read/29621833/an-image-processing-and-genetic-algorithm-based-approach-for-the-detection-of-melanoma-in-patients
#8
Christian Salem, Danielle Azar, Sima Tokajian
Melanoma skin cancer is the most aggressive type of skin cancer. It is most commonly caused by excessive exposure to Ultraviolet radiation which triggers uncontrollable proliferation of melanocytes. Early detection makes melanoma relatively easily curable. Diagnosis is usually done using traditional methods such as dermoscopy which consists of a manual examination performed by the physician. However, these methods are not always well founded because they depend heavily on the physician's experience. Hence, there is a great need for a new automated approach in order to make diagnosis more reliable...
February 2018: Methods of Information in Medicine
https://www.readbyqxmd.com/read/29611194/recognition-of-early-melanoma-a-monocentric-dermoscopy-follow-up-study-comparing-de-novo-melanoma-with-nevus-associated-melanoma
#9
David Alvarez Martinez, Wolf-Henning Boehncke, Gürkan Kaya, Rastine Merat
BACKGROUND: The earlier detection of melanomas occurring within preexisting nevi is theoretically possible using sequential dermoscopy. Characterizing the early follow-up changes of nevus-associated melanomas (NAMs) and differentiating them from those observed in de novo melanomas (DNMs) may help the earlier recognition of NAMs. METHODS: Using descriptive dermoscopic features to detect focal changes, we blindly evaluated retrospectively the baseline and follow-up images of 32 melanomas that were subsequently classified as histopathologically defined NAMs or DNMs...
April 2, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29599670/dermoscopic-assessment-of-skin-toxicities-in-patients-with-melanoma-during-treatment-with-vemurafenib
#10
Marcin Rajczykowski, Grazyna Kaminska-Winciorek, Elzbieta Nowara, Marzenna Samborska-Plewicka, Sebastian Giebel
Introduction: The use of vemurafenib in melanoma has improved the survival of patients; however, it is associated with skin toxicities. Aim: To assess skin toxicities by dermoscopy in patients treated with vemurafenib. Material and methods: Eight patients with BRAF V600 mutation positive metastatic melanoma were examined dermoscopically during vemurafenib treatment. All skin lesions occurring during therapy were assessed clinically and dermoscopically using a hand-held dermoscope with polarised and non-polarised light...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29575271/oct-image-atlas-of-healthy-skin-on-sun-exposed-areas
#11
S O'Leary, A Fotouhi, D Turk, P Sriranga, A Rajabi-Estarabadi, K Nouri, S Daveluy, D Mehregan, M Nasiriavanaki
BACKGROUND: Skin cancer represents the most prevalent type of cancer in the United States. Excision of these lesions can leave significant scarring, and a delay in the diagnosis of malignant melanoma could result in metastasis or death. Therefore, developing technology and criteria to accurately diagnose these cancers is of particular importance to the medical community. While biopsy can lead to scarring and infections, dermoscopy and confocal microscopy offer noninvasive imaging methods but are also limited in their ability to determine tumor depth and margins...
March 25, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29569417/dermoscopy-features-of-atypical-fibroxanthoma-a-multicenter-study-of-the-international-dermoscopy-society
#12
Elvira Moscarella, Simonetta Piana, Francesca Specchio, Athanassios Kyrgidis, Gianluca Nazzaro, Maite L Eliceche, Francesco Savoia, Leonardo Bugatti, Giorgio Filosa, Iris Zalaudek, Federica Scarfi, Mike Inskip, Cliff Rosendahl, John H Pyne, Graeme Siggs, Arzu K Toğral, Horatio Cabo, Lubomir Drlik, Aimilios Lallas, Caterina Longo, Giuseppe Argenziano
BACKGROUND/OBJECTIVES: Little is known about the dermoscopic features of atypical fibroxanthoma. METHODS: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. RESULTS: Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%)...
March 23, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29569229/diagnostic-accuracy-of-dermatofluoroscopy-in-cutaneous-melanoma-detection-results-of-a-prospective-multicentre-clinical-study-in-476-pigmented-lesions
#13
A Forschner, U Keim, M Hofmann, I Spänkuch, D Lomberg, B Weide, I Tampouri, T Eigentler, C Fink, C Garbe, H A Haenssle
BACKGROUND: Early detection is a key factor in improving survival from melanoma. Today, the clinical diagnosis of cutaneous melanoma is mostly based on visual inspection and dermoscopy. Preclinical studies in freshly excised or paraffin-embedded tissue have shown that the melanin fluorescence spectra after stepwise two-photon excitation, a process termed dermatofluoroscopy, differ between cutaneous melanoma and melanocytic nevi. However, confirmation from a larger prospective clinical study is lacking...
March 22, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29528027/a-multicenter-survey-how-do-transplant-dermatologists-monitor-organ-transplant-recipients-with-nevi
#14
Deren Özcan, Deniz Seçkin, Mehmet Haberal
OBJECTIVES: The incidence and mortality of melanoma are increased in organ transplant recipients. Multiple acquired common and dysplastic nevi are risk factors for melanoma. A new or changing nevus may suggest melanoma. Strategies used by transplant dermatologists to monitor nevi are unknown. Herein, we aimed to assess the methods used by transplant dermatologists for monitoring multiple acquired common nevi, dysplastic nevi, and new or changing nevi. MATERIALS AND METHODS: A questionnaire was e-mailed to 63 members of the Skin Care in Organ Transplant Patients, Europe...
March 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29513718/acral-melanoma-detection-using-a-convolutional-neural-network-for-dermoscopy-images
#15
Chanki Yu, Sejung Yang, Wonoh Kim, Jinwoong Jung, Kee-Yang Chung, Sang Wook Lee, Byungho Oh
BACKGROUND/PURPOSE: Acral melanoma is the most common type of melanoma in Asians, and usually results in a poor prognosis due to late diagnosis. We applied a convolutional neural network to dermoscopy images of acral melanoma and benign nevi on the hands and feet and evaluated its usefulness for the early diagnosis of these conditions. METHODS: A total of 724 dermoscopy images comprising acral melanoma (350 images from 81 patients) and benign nevi (374 images from 194 patients), and confirmed by histopathological examination, were analyzed in this study...
2018: PloS One
https://www.readbyqxmd.com/read/29512974/acral-melanoma-correlating-the-clinical-presentation-to-the-mutational-status
#16
Giulia M Ravaioli, Emi Dika, Martina Lambertini, Marco A Chessa, Pier A Fanti, Annalisa Patrizi
Acral lentiginous melanoma (ALM) is the most common type of malignant melanoma (MM) in Asians, Afro-Americans and Middle-Easterns. It represents 1.5-10% of all MM cases, being the most common histological type of MM arising on palms, soles and nail apparatus, which is more generically defined as acral MM. To date no risk factors have been officially established, however a history of trauma may be involved in the pathogenesis of acral MM. This shows heterogeneous clinical features and frequently presents with advanced stage and aggressive behaviour, often as a result of misdiagnosis or delayed identification...
March 6, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29502116/dermoscopy-improves-the-diagnostic-accuracy-of-melanomas-clinically-resembling-seborrheic-keratosis-cross-sectional-study-of-the-ability-to-detect-seborrheic-keratosis-like-melanomas-by-a-group-of-dermatologists-with-varying-degrees-of-experience
#17
Cristina Carrera, Sonia Segura, Paula Aguilera, Carol Midori Takigami, Antonio Gomes, Alicia Barreiro, Massimiliano Scalvenzi, Caterina Longo, Stefano Cavicchini, Luc Thomas, Josep Malvehy, Susana Puig, Iris Zalaudek
BACKGROUND: Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value of dermoscopy to improve the correct detection of these mimickers has not been previously studied. OBJECTIVE: To evaluate the diagnostic accuracy of clinically SK-like MMs with and without dermoscopy. METHODS: Clinical and dermoscopic images of histopathologically proven SK-like MMs (n = 134) intermingled with other melanomas and benign tumors were randomly presented to clinicians with different levels of experience, blinded to the diagnosis and goal of the study...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29485257/pediatric-melanoma-update
#18
Lindsay McCORMACK, Elena B Hawryluk
Pediatric melanoma is a rare disease that affects approximately 6 out of every one million children and accounts for 1-4 percent of all melanomas. This article reviews the epidemiology, etiology, diagnosis, treatment and prognosis of pediatric melanoma - with particular attention to recent updates in the literature. While awareness of melanoma increases among the general population, recent data suggest stable and even declining incidence rates among certain pediatric populations. Studies have examined clinical features and presentations of melanoma among the pediatric population and the conventional ABCDE criteria used to diagnosis adult melanoma may not be entirely appropriate for pediatric melanoma; as such, additional pediatric-ABCD and CUP criteria have been proposed...
February 26, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29484015/small-dysplastic-congenital-melanocytic-nevi-in-childhood-as-possible-melanoma-imitators
#19
Georgi Tchernev, Anastasiya Atanasova Chokoeva, Ivan Terziev, Yavor Grigorov, Torello Lotti, Uwe Wollina, José Carlos Cardoso, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
Small pigmented lesions in children can represent a significant diagnostic challenge. If the diagnostic features and therapeutic approach are relatively well established in large and giant nevi, there is still much controversy regarding small and intermediate-sized congenital pigmented lesions that can lead to significant diagnostic challenges, both clinically and dermoscopically, and consequently to difficulty in defining the optimal approach in such cases. Although dermoscopy can be useful in the diagnosis of pigmented lesions, the diversity of clinical and dermoscopic features of pigmented nevi in children usually hinder the differentiation between them and melanoma...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29483981/subungual-exostosis-in-a-young-soccer-player
#20
Georgi Tchernev, Yavor Grigorov, Stanislav Philipov, Anastasiya Chokoeva, Uwe Wollina, Torello Lotti, Jose Cardoso, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
BACKGROUND: Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx of the toes or fingers in young adults, considered as a rare variant of osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic subungual melanoma and glomus tumour. Misdiagnosis and total onychodystrophy frequently occur as a result of late treatment or inadequate treatment strategy. Dermoscopy could be a useful technique, involved in the diagnostic process, although X-ray examination and histopathology are mandatory for the diagnosis...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
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