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https://www.readbyqxmd.com/read/29220316/edge-based-defocus-blur-estimation-with-adaptive-scale-selection
#1
Ali Karaali, Claudio Rosito Jung
Objects that do not lie at the focal distance of a digital camera generate defocused regions in the captured image. This paper presents a new edge-based method for spatially varying defocus blur estimation using a single image based on reblurred gradient magnitudes. The proposed approach initially computes a scale-consistent edge map of the input image and selects a local reblurring scale aiming to cope with noise, edge mis-localization, and interfering edges. An initial blur estimate is computed at the detected scale-consistent edge points and a novel connected edge filter is proposed to smooth the sparse blur map based on pixel connectivity within detected edge contours...
March 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29216311/amelioration-of-sexual-behavior-and-motor-activity-deficits-in-a-castrated-rodent-model-with-a-selective-androgen-receptor-modulator-sarm-2f
#2
Megumi Morimoto, Yuichiro Amano, Masahiro Oka, Ayako Harada, Hisashi Fujita, Yukiko Hikichi, Ryuichi Tozawa, Masuo Yamaoka, Takahito Hara
Sarcopenia and cachexia present characteristic features of a decrease in skeletal muscle mass and strength, anorexia, and lack of motivation. Treatments for these diseases have not yet been established, although selective androgen receptor modulators (SARMs) are considered as therapeutic targets. We previously reported that a novel SARM compound, SARM-2f, exhibits anabolic effect on muscles, with less stimulatory effect on prostate weight compared with testosterone, in rat Hershberger assays and cancer cachexia models...
2017: PloS One
https://www.readbyqxmd.com/read/29203355/a-randomized-placebo-controlled-phase-3-trial-of-an-antisense-oligonucleotide-drisapersen-in-duchenne-muscular-dystrophy
#3
Nathalie Goemans, Eugenio Mercuri, Elena Belousova, Hirofumi Komaki, Alberto Dubrovsky, Craig M McDonald, John E Kraus, Afrodite Lourbakos, Zhengning Lin, Giles Campion, Susanne X Wang, Craig Campbell
This 48-week, randomized, placebo-controlled phase 3 study (DMD114044; NCT01254019) evaluated efficacy and safety of subcutaneous drisapersen 6 mg/kg/week in 186 ambulant boys aged ≥5 years, with Duchenne muscular dystrophy (DMD) resulting from an exon 51 skipping amenable mutation. Drisapersen was generally well tolerated, with injection-site reactions and renal events as most commonly reported adverse events. A nonsignificant treatment difference (P = 0.415) in the change from baseline in six-minute walk distance (6MWD; primary efficacy endpoint) of 10...
December 1, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/29200895/physiological-and-training-characteristics-of-recreational-marathon-runners
#4
Dan Gordon, Sarah Wightman, Itay Basevitch, James Johnstone, Carolina Espejo-Sanchez, Chelsea Beckford, Mariette Boal, Adrian Scruton, Mike Ferrandino, Viviane Merzbach
Purpose: The aim of this study was to examine the physical and training characteristics of recreational marathon runners within finish time bandings (2.5-3 h, 3-3.5 h, 3.5-4 h, 4-4.5 h and >4.5 h). Materials and methods: A total of 97 recreational marathon runners (age 42.4 ± 9.9 years; mass 69.2 ± 11.3 kg; stature 172.8 ± 9.1 cm), with a marathon finish time of 229.1 ± 48.7 min, of whom n = 34 were female and n = 63 were male, completed an incremental treadmill test for the determination of lactate threshold (LT1), lactate turn point (LT2) and running economy (RE)...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/29199781/velocity-distribution-of-women-s-30-km-cross-country-skiing-during-olympic-games-from-2002-2014
#5
Wlodzimierz S Erdmann, Dorota Dancewicz-Nosko, Vasilios Giovanis
BACKGROUND: Within several investigated endurance sport disciplines the distribution of load of the best competitors has a manner of evenly or slightly rising velocity values. Unfortunately many other competitors have usually diminishing values or when they are very poor they have evenly values. The aim of this study was to investigate distribution of velocity within 30-km cross-country female skiers. METHODS: Cross-country skiing runs were investigated of Olympic Games 2002-2014 (Salt Lake City, Turin, Vancouver, Sochi)...
December 1, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29195201/a-fuzzy-multicriteria-categorization-of-the-galdit-method-to-assess-seawater-intrusion-vulnerability-of-coastal-aquifers
#6
Nerantzis Kazakis, Mike Spiliotis, Konstantinos Voudouris, Fotios-Konstantinos Pliakas, Basil Papadopoulos
Groundwater constitutes the primary source of fresh water for >1.2 billion people living in coastal zones. However, the threat of seawater intrusion is widespread in coastal aquifers mainly due to overexploitation of groundwater. In the present study, a modified fuzzy multicriteria categorization into non-ordered categories method was developed in order to modify the standard GALDIT method and assess seawater intrusion vulnerability in a coastal aquifer of northern Greece. The method is based on six parameters: groundwater occurrence, aquifer hydraulic conductivity, groundwater level, distance from the shore, impact of the existing status of seawater intrusion, and aquifer thickness...
November 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29193059/exercise-improves-nicotine-reward-associated-cognitive-behaviors-and-related-%C3%AE-7-nachr-mediated-signal-transduction-in-adolescent-rats
#7
Yuehui Zhou, Cuicui Li, Rena Li, Chenglin Zhou
The adolescent brain is vulnerable to long-lasting cognitive disturbances resulting from nicotine exposure. Although exercise has been used as an intervention for ameliorating cognitive deficits in various disorders, the effect on cognitive changes induced by nicotine exposure and its underlying mechanisms remain unclear. The purpose of this study was to investigate the effects of exercise on nicotine reward-associated cognitive behaviors in adolescent rats subjected to nicotine conditioned place preference paradigm (CPP)...
November 29, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29192842/validity-of-an-ultra-wideband-local-positioning-system-to-measure-locomotion-in-indoor-sports
#8
F R Serpiello, W G Hopkins, S Barnes, J Tavrou, G M Duthie, R J Aughey, K Ball
The validity of an Ultra-wideband (UWB) positioning system was investigated during linear and change-of-direction (COD) running drills. Six recreationally-active men performed ten repetitions of four activities (walking, jogging, maximal acceleration, and 45º COD) on an indoor court. Activities were repeated twice, in the centre of the court and on the side. Participants wore a receiver tag (Clearsky T6, Catapult Sports) and two reflective markers placed on the tag to allow for comparisons with the criterion system (Vicon)...
December 1, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29182410/the-effect-of-periodisation-and-training-intensity-distribution-on-middle-and-long-distance-running-performance-a-systematic-review
#9
Mark Kenneally, Arturo Casado, Jordan Santos-Concejero
This review aimed to examine the current evidence for three primary training intensity distribution types; 1) Pyramidal Training, 2) Polarised Training and 3) Threshold Training. Where possible, we calculated training intensity zones relative to the goal race pace, rather than physiological or subjective variables. We searched 3 electronic databases in May 2017 (PubMed, Scopus, and Web of Science) for original research articles. After analysing 493 resultant original articles, studies were included if they met the following criteria: a) participants were middle- or long-distance runners; b) studies analysed training intensity distribution in the form of observational reports, case studies or interventions; c) studies were published in peer-reviewed journals and d) studies analysed training programs with a duration of 4 weeks or longer...
November 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29179765/using-peer-advocates-to-improve-access-to-services-among-hard-to-reach-populations-with-hepatitis-c-a-qualitative-study-of-client-and-provider-relationships
#10
Jennifer MacLellan, Julian Surey, Ibrahim Abubakar, Helen R Stagg, Jenevieve Mannell
BACKGROUND: Peer support programmes use individuals with specific experiences to improve engagement and outcomes among new clients. However, the skills and techniques used to achieve this engagement have not been mapped. This potentially restricts the development and replication of successful peer advocate models of care. This study explored how a group of peer advocates with experience of homelessness, alcohol and drug misuse made and sustained relationships with their client group. For the purposes of this project, the client group were located among a hepatitis C-positive cohort of people who have a history of injecting drug use and homelessness...
November 28, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/29178677/respiratory-function-and-symptoms-post-cold-air-exercise-in-female-high-and-low-ventilation-sport-athletes
#11
Michael D Kennedy, Martin Faulhaber
PURPOSE: Cold weather exercise is common in many regions of the world; however, it is unclear whether respiratory function and symptom worsen progressively with colder air temperatures. Furthermore, it is unclear whether high-ventilation sport background exacerbates dysfunction and symptoms. METHODS: Seventeen active females (measure of the maximum volume of oxygen [VO(2max)]: 49.6±6.6 mL·kg⁻¹·min⁻¹) completed on different days in random order 5 blinded running trials at 0°C, -5°C, -10°C, -15°C, and -20°C (humidity 40%) in an environmental chamber...
January 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29176385/positional-differences-in-running-and-non-running-activities-during-elite-american-football-training
#12
Patrick A Ward, Sam Ramsden, Aaron J Coutts, Andrew T Hulton, Barry Drust
The aim of this investigation was to describe differences in training loads between position groups within professional American football. Integrated micro technology data was collected on 63 NFL football players during an American football training camp. Five key metrics (total distance, high speed distance, Player Load, Player Load per Minute, and Total Inertial Movement Analysis (IMA)) served to quantify both running and non-running activities. Players were classified into position groups (DB, DL, LB, OL, QB, RB, TE, and WR)...
November 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29176384/the-use-of-mobile-applications-to-collect-data-in-sport-health-and-exercise-science-a-narrative-review
#13
Daniel J Peart, Carlos Balsalobre-Fernández, Matthew P Shaw
Mobile devices are ubiquitous in the population, and most have the capacity to download applications (apps). Some apps have been developed to collect physiological, kinanthropometric and performance data, however the validity and reliability of such data is often unknown. An appraisal of such apps is warranted as mobile apps may offer an alternative method of data collection for practitioners and athletes with money, time and space constraints. This article identifies and critically reviews the commercially available apps that have been tested in the scientific literature, finding evidence to support the measurement of resting heart through photoplethysmograpy, heart rate variability, range of motion, barbell velocity, vertical jump, mechanical variables during running, and distances covered during walking, jogging and running...
November 22, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29175485/short-and-long-term-exposure-to-low-and-high-dose-running-produce-differential-effects-on-hippocampal-neurogenesis
#14
Carine Nguemeni, Matthew W McDonald, Matthew S Jeffers, Jessica Livingston-Thomas, Diane Lagace, Dale Corbett
Continuous running wheel (RW) exercise increases adult hippocampal neurogenesis in the dentate gyrus (DG) of rodents. Evidence suggests that greater amounts of RW exercise does not always equate to more adult-generated neurons in hippocampus. It can also be argued that continuous access to a RW results in exercise levels not representative of human exercise patterns. This study tested if RW paradigms that more closely represent human exercise patterns (e.g. shorter bouts, alternating daily exercise) alter neurogenesis...
November 22, 2017: Neuroscience
https://www.readbyqxmd.com/read/29170574/the-checkpoint-ordering-problem
#15
P Hungerländer
We suggest a new variant of a row layout problem: Find an ordering of n departments with given lengths such that the total weighted sum of their distances to a given checkpoint is minimized. The Checkpoint Ordering Problem (COP) is both of theoretical and practical interest. It has several applications and is conceptually related to some well-studied combinatorial optimization problems, namely the Single-Row Facility Layout Problem, the Linear Ordering Problem and a variant of parallel machine scheduling. In this paper we study the complexity of the (COP) and its special cases...
October 3, 2017: Optimization
https://www.readbyqxmd.com/read/29167568/elite-long-jumpers-with-below-the-knee-prostheses-approach-the-board-slower-but-take-off-more-effectively-than-non-amputee-athletes
#16
Steffen Willwacher, Johannes Funken, Kai Heinrich, Ralf Müller, Hiroaki Hobara, Alena M Grabowski, Gert-Peter Brüggemann, Wolfgang Potthast
The use of technological aids to improve sport performance ('techno doping') and inclusion of Paralympic athletes in Olympic events are matters of ongoing debate. Recently, a long jumper with a below the knee amputation (BKA) achieved jump distances similar to world-class athletes without amputations, using a carbon fibre running-specific prosthesis (RSP). We show that athletes with BKA utilize a different, more effective take-off technique in the long jump, which provided the best athlete with BKA a performance advantage of at least 0...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29165377/a-novel-3d-pedestrian-navigation-method-for-a-multiple-sensors-based-foot-mounted-inertial-system
#17
Wei Yang, Chundi Xiu, Jianmin Zhang, Dongkai Yang
In this paper, we present a novel method for 3D pedestrian navigation of foot-mounted inertial systems by integrating a MEMS-IMU, barometer, and permanent magnet. Zero-velocity update (ZUPT) is a well-known algorithm to eliminate the accumulated error of foot-mounted inertial systems. However, the ZUPT stance phase detector using acceleration and angular rate is threshold-based, which may cause incorrect stance phase estimation in the running gait pattern. A permanent magnet-based ZUPT detector is introduced to solve this problem...
November 22, 2017: Sensors
https://www.readbyqxmd.com/read/29163210/a-wearable-test-for-maximum-aerobic-power-real-time-analysis-of-a-60-m-sprint-performance-and-heart-rate-off-kinetics
#18
Jorge L Storniolo, Gaspare Pavei, Alberto E Minetti
Maximum aerobic power ([Formula: see text]) as an indicator of body fitness is today a very well-known concept not just for athletes but also for the layman. Unfortunately, the accurate measurement of that variable has remained a complex and exhaustive laboratory procedure, which makes it inaccessible to many active people. In this paper we propose a quick estimate of it, mainly based on the heart rate off-kinetics immediately after an all-out 60-m sprint run. The design of this test took into account the recent availability of wrist wearable, heart band free, multi-sensor smart devices, which could also inertially detect the different phases of the sprint and check the distance run...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29162030/fast-batch-searching-for-protein-homology-based-on-compression-and-clustering
#19
Hongwei Ge, Liang Sun, Jinghong Yu
BACKGROUND: In bioinformatics community, many tasks associate with matching a set of protein query sequences in large sequence datasets. To conduct multiple queries in the database, a common used method is to run BLAST on each original querey or on the concatenated queries. It is inefficient since it doesn't exploit the common subsequences shared by queries. RESULTS: We propose a compression and cluster based BLASTP (C2-BLASTP) algorithm to further exploit the joint information among the query sequences and the database...
November 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29160723/automation-of-a-dosing-disc-capsule-filler-from-the-perspective-of-reliability-and-safety
#20
Bernhard Wagner, Thomas Brinz, Stephanie Otterbach, Johannes Khinast
The aim of this paper is to explore the possibility to develop an automatically adjustable, reliable and safe capsule filling operation. Process parameters that are critical for the tamping pin process were reviewed based on the literature and via experiment. Dosing disc height, powder bed height, machine speed, pressure on the tamping pin and immersion depth were reviewed. Two investigations were performed on a GKF 702. In the first one, the powder feed rate onto the dosing disc was examined and modified. A distance sensor with a PID controller enabled a constant powder bed level with an online changeable set point...
November 21, 2017: Drug Development and Industrial Pharmacy
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