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ventricular ectopy

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https://www.readbyqxmd.com/read/27875987/biomarkers-of-cardiovascular-injury-and-stress-are-associated-with-increased-frequency-of-ventricular-ectopy-a-population-based-study
#1
Julia Brox Skranes, Gunnar Einvik, Silje Kjeka Namtvedt, Anna Randby, Harald Hrubos-Strøm, Jon Brynildsen, Tor-Arne Hagve, Virend K Somers, Helge Røsjø, Torbjørn Omland
BACKGROUND: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting...
November 22, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27867290/ranolazine-is-an-effective-and-safe-treatment-of-adults-with-symptomatic-premature-ventricular-contractions-due-to-triggered-ectopy
#2
Gary L Murray
Early and delayed afterdepolarizations (EAD/DAD) cause triggered ventricular ectopy. Because ranolazine (RAN) suppresses EAD/DAD, we postulated that RAN might be effective in reducing premature ventricular contractions (PVCs). To assess the effect of RAN in patients with symptomatic PVCs due to triggered ectopy and its safety and tolerability. A total of 59 patients with symptomatic PVCs were identified from full-disclosure Holters. Doses of 500 and 1,000 mg offlabel RAN, daily, were given to 34 and 66% patients, respectively, and repeat Holters were performed prospectively during mean followup of 3...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27867071/evaluation-of-a-novel-high-resolution-mapping-system-for-catheter-ablation-of-ventricular-arrhythmias
#3
Karthik Viswanathan, Lilian Mantziari, Charles Butcher, Emily Hodkinson, Eric Lim, Habib Khan, Sandeep Panikker, Shouvik Haldar, Julian W E Jarman, David G Jones, Wajid Hussain, John P Foran, Vias Markides, Tom Wong
BACKGROUND: The mapping of ventricular arrhythmias in humans using a mini-basket 64-electrode catheter paired with a novel automatIc mapping system (Rhythmia(TM)) has not been evaluated. OBJECTIVE: To evaluate the safety and efficacy of mapping ventricular arrhythmias and clinical outcomes after ablation using this system. METHODS: Electroanatomic (EA) maps for ventricular arrhythmias were obtained during 20 consecutive procedures in 19 patients (ventricular tachycardia [VT] 12; ventricular ectopy [VE] 7)...
November 17, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27815173/stable-gastric-pentadecapeptide-bpc-157-and-bupivacaine
#4
Gordana Zivanovic-Posilovic, Diana Balenovic, Ivan Barisic, Dean Strinic, Vasilije Stambolija, Mario Udovicic, Sandra Uzun, Domagoj Drmic, Josipa Vlainic, Martina Lovric Bencic, Aleksandra Sindic, Sven Seiwerth, Predrag Sikiric
Bupivacaine toxicity following accidental overdose still lacks therapeutic solution. However, there are major arguments for testing BPC 157 against bupivacaine toxicity in vivo in rats, in particular, and then finally, in vitro. These are: the lack of any known BPC 157 toxicity, a lifesaving effect via the mitigation of arrhythmias in rats underwent hyperkalemia or digitalis toxicity, the elimination of hyperkalemia and arrhythmias in rats underwent succinylcholine toxicity and finally, the reduction of potassium-induced depolarization in vitro (in HEK293 cells) in severe hyperkalemia...
November 1, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27802959/ventricular-ectopy-in-hospitalized-elderly-adults
#5
Mary G Carey, Teri M Kozik, Michele M Pelter, Salah S Al-Zaiti
No abstract text is available yet for this article.
November 2016: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/27778458/t-wave-alternans-heart-rate-turbulence-and-ventricular-ectopy-in-standard-versus-daily-hemodialysis-results-from-the-fhn-daily-trial
#6
Rachel M Kaplan, Charles A Herzog, Brett Larive, Haris Subacius, Bruce D Nearing, Richard Verrier, Rod S Passman
BACKGROUND: Hemodialysis (HD) patients are at high risk of sudden cardiac death (SCD). HD 6-times/week (6x/wk) may reduce SCD risk compared to usual 3-times/week HD (3x/wk) by mechanisms unknown. T-wave alternans (TWA), heart rate turbulence (HRT), and ventricular ectopy (VE) are elevated in HD patients, but their response to 6x/wk HD has not been assessed. METHODS: Baseline and 1-year Holter recordings were analyzed from enrollees in the Frequent Hemodialysis Network Daily Trial, a randomized trial comparing 3x/wk to 6x/wk in 245 chronic HD patients...
November 2016: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/27772664/follow-up-of-electrocardiographic-findings-and-arrhythmias-in-patients-with-anomalously-arising-left-coronary-artery-from-the-pulmonary-trunk
#7
Judson A Moore, Antonio G Cabrera, Jeffrey J Kim, Santiago O Valdés, Caridad de la Uz, Christina Y Miyake
Follow-up data and correlation of arrhythmias, electrocardiogram (ECG) changes, and cardiac function in anomalous left coronary artery from the pulmonary trunk or artery have not been previously studied. This is a retrospective single-center review of 44 anomalous left coronary artery from the pulmonary trunk or artery patients diagnosed between 1992 and 2014, at a median age of 3 months (3 days to 13 years). Clinical history, ECG, Holter, and echocardiogram data were reviewed. ECGs were reviewed for contiguous Q-or T-wave inversions, hypertrophy, bundle branch block, and axis deviation...
September 23, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27728077/ventricular-ectopy-in-structurally-normal-heart-response-to-beta-blocker-case-report-of-three-cases
#8
C Guruchaithanya Kumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27579717/self-gated-mri-of-multiple-beat-morphologies-in-the-presence-of-arrhythmias
#9
Francisco Contijoch, Srikant Kamesh Iyer, James J Pilla, Paul Yushkevich, Joseph H Gorman, Robert C Gorman, Harold Litt, Yuchi Han, Walter R T Witschey
PURPOSE: Develop self-gated MRI for distinct heartbeat morphologies in subjects with arrhythmias. METHODS: Golden angle radial data was obtained in seven sinus and eight arrhythmias subjects. An image-based cardiac navigator was derived from single-shot images, distinct beat types were identified, and images were reconstructed for repeated morphologies. Image sharpness, contrast, and volume variation were quantified and compared with self-gated MRI. Images were scored for image quality and artifacts...
August 31, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27521094/ventricular-arrhythmias-in-apparently-normal-hearts-who-needs-an-implantable-cardiac-defibrillator
#10
REVIEW
Alex Y Tan, Kenneth Ellenbogen
Idiopathic ventricular tachycardia is often considered a benign form of ventricular arrhythmia in patients without apparent structural heart disease. However, a subset of patients may develop malignant ventricular arrhythmias and present with syncope and sudden cardiac arrest. Survivors of cardiac arrest are candidates for implantable cardiac defibrillators (ICDs). The indications for ICDs in patients with less than a full-blown cardiac arrest presentation but with electrocardiographically high-risk ectopy features remain uncertain...
September 2016: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/27516456/novel-cpvt-associated-calmodulin-mutation-in-calm3-calm3-a103v-activates-arrhythmogenic-ca-waves-and-sparks
#11
Nieves Gomez-Hurtado, Nicole J Boczek, Dmytro O Kryshtal, Christopher N Johnson, Jennifer Sun, Florentin R Nitu, Razvan L Cornea, Walter J Chazin, Melissa L Calvert, David J Tester, Michael J Ackerman, Björn C Knollmann
BACKGROUND: Calmodulin (CaM) mutations are associated with severe forms of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT). CaM mutations are found in 13% of genotype-negative long QT syndrome patients, but the prevalence of CaM mutations in genotype-negative CPVT patients is unknown. Here, we identify and characterize CaM mutations in 12 patients with genotype-negative but clinically diagnosed CPVT. METHODS AND RESULTS: We performed mutational analysis of CALM1, CALM2, and CALM3 gene-coding regions, in vitro measurement of CaM-Ca(2+) (Ca)-binding affinity, ryanodine receptor 2-CaM binding, Ca handling, L-type Ca current, and action potential duration...
August 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27341045/comparative-observational-study-on-the-clinical-presentation-intracranial-volume-measurements-and-intracranial-pressure-scores-in-patients-with-either-chiari-malformation-type-i-or-idiopathic-intracranial-hypertension
#12
Radek Frič, Per Kristian Eide
OBJECTIVE Several lines of evidence suggest common pathophysiological mechanisms in Chiari malformation Type I (CMI) and idiopathic intracranial hypertension (IIH). It has been hypothesized that tonsillar ectopy, a typical finding in CMI, is the result of elevated intracranial pressure (ICP) combined with a developmentally small posterior cranial fossa (PCF). To explore this hypothesis, the authors specifically investigated whether ICP is comparable in CMI and IIH and whether intracranial volumes (ICVs) are different in patients with CMI and IIH, which could explain the tonsillar ectopy in CMI...
June 24, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27338494/electrocardiographic-differentiation-of-idiopathic-right-ventricular-outflow-tract-ectopy-from-early-arrhythmogenic-right-ventricular-cardiomyopathy
#13
Jan Novak, Alessandro Zorzi, Silvia Castelletti, Antonis Pantasis, Ilaria Rigato, Domenico Corrado, William Mckenna, Pier D Lambiase
AIMS: The differentiation between idiopathic right ventricular outflow tract (RVOT) arrhythmias and early arrhythmogenic right ventricular cardiomyopathy (ARVC) can be challenging. We aimed to assess whether QRS morphological features and coupling interval of ventricular ectopic beats (VEBs) can improve differentiation between the two conditions. METHODS AND RESULTS: Twenty desmosomal-gene mutation carriers (13 females, mean age 43 years) with no or mild ARVC phenotypic expression and 33 age- and sex-matched subjects with idiopathic RVOT arrhythmias were studied...
June 23, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27214373/inhibition-of-cardiac-kir-current-ik1-by-protein-kinase-c-critically-depends-on-pkc%C3%AE-and-kir2-2
#14
Daniel Scherer, Claudia Seyler, Panagiotis Xynogalos, Eberhard P Scholz, Dierk Thomas, Johannes Backs, Martin Andrassy, Mirko Völkers, Christoph A Karle, Hugo A Katus, Edgar Zitron
BACKGROUND: Cardiac inwardly rectifying Kir current (IK1) mediates terminal repolarisation and is critical for the stabilization of the diastolic membrane potential. Its predominant molecular basis in mammalian ventricle is heterotetrameric assembly of Kir2.1 and Kir2.2 channel subunits. It has been shown that PKC inhibition of IK1 promotes focal ventricular ectopy. However, the underlying molecular mechanism has not been fully elucidated to date. METHODS AND RESULTS: In the Xenopus oocyte expression system, we observed a pronounced PKC-induced inhibition of Kir2...
2016: PloS One
https://www.readbyqxmd.com/read/27196746/transient-elimination-of-posterior-right-ventricular-outflow-tract-ectopy-by-sternal-pressure
#15
Marcus Wieczorek, Reinhard Hoeltgen
BACKGROUND: Ventricular ectopy (VE) originating in the right ventricular outflow tract (RVOT) is a common arrhythmia. Mechanisms triggering or eliminating VE from RVOT are not entirely understood. CASE REPORT: A patient with frequent, symptomatic VE underwent an electrophysiologic study: VE origin was mapped by NavX 3D navigation. Incidental pressure applied manually to the sternum reproducibly eliminated VE for the time of exposure. RF-Ablation was successfully performed in the posterior RVOT...
May 16, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27170944/central-role-for-gsk3%C3%AE-in-the-pathogenesis-of-arrhythmogenic-cardiomyopathy
#16
Stephen P Chelko, Angeliki Asimaki, Peter Andersen, Djahida Bedja, Nuria Amat-Alarcon, Deeptankar DeMazumder, Ravirasmi Jasti, Calum A MacRae, Remo Leber, Andre G Kleber, Jeffrey E Saffitz, Daniel P Judge
Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional proteins, arrhythmias, and progressive myocardial injury. We previously reported that SB216763 (SB2), annotated as a GSK3β inhibitor, reverses disease phenotypes in a zebrafish model of ACM. Here, we show that SB2 prevents myocyte injury and cardiac dysfunction in vivo in two murine models of ACM at baseline and in response to exercise. SB2-treated mice with desmosome mutations showed improvements in ventricular ectopy and myocardial fibrosis/inflammation as compared with vehicle-treated (Veh-treated) mice...
April 21, 2016: JCI Insight
https://www.readbyqxmd.com/read/27154230/mitochondrial-oxidative-stress-during-cardiac-lipid-overload-causes-intracellular-calcium-leak-and-arrhythmia
#17
Leroy C Joseph, Prakash Subramanyam, Christopher Radlicz, Chad M Trent, Vivek Iyer, Henry M Colecraft, John P Morrow
BACKGROUND: Diabetes and obesity are associated with an increased risk of arrhythmia and sudden cardiac death. Abnormal lipid accumulation is observed in cardiomyocytes of obese and diabetic patients, which may contribute to arrhythmia, but the mechanisms are poorly understood. A transgenic mouse model of cardiac lipid overload, the peroxisome proliferator-activated receptor-γ (PPARg) cardiac overexpression mouse, has long QT and increased ventricular ectopy. OBJECTIVE: The purpose of this study was to evaluate the hypothesis that the increase in ventricular ectopy during cardiac lipid overload is caused by abnormalities in calcium handling due to increased mitochondrial oxidative stress...
August 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27108363/advances-in-the-diagnosis-and-management-of-arrhythmogenic-right-ventricular-dysplasia-cardiomyopathy
#18
REVIEW
Gabriela M Orgeron, Hugh Calkins
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy characterized by ventricular arrhythmias, right ventricular dysfunction, and sudden cardiac death. Since the first description of ARVD/C in 1982, there have been major advances in the diagnosis and management of the disease. For instance, the discovery of desmosomal abnormalities as a genetic basis for ARVD/C; the importance of proband status and ventricular ectopy for risk stratification of patients at risk for sudden cardiac death; and the critical role that exercise plays in the development and progression of ARVD/C, just to name a few...
June 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/27103091/sites-of-successful-ventricular-fibrillation-ablation-in-bileaflet-mitral-valve-prolapse-syndrome
#19
Faisal F Syed, Michael J Ackerman, Christopher J McLeod, Suraj Kapa, Siva K Mulpuru, Chenni S Sriram, Bryan C Cannon, Samuel J Asirvatham, Peter A Noseworthy
BACKGROUND: Although the vast majority of mitral valve prolapse (MVP) is benign, a small subset of patients, predominantly women, with bileaflet prolapse, complex ventricular ectopy (VE), and abnormal T waves comprise the recently described bileaflet MVP syndrome. We compared findings on electrophysiological study in bileaflet MVP syndrome patients with and without cardiac arrest to identify factors that may predispose to malignant ventricular arrhythmia. METHODS AND RESULTS: Fourteen consecutive bileaflet MVP syndrome patients (n=13 women; median [limits], age at index ablation, 33...
May 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27085207/blood-pressure-response-is-impaired-in-patients-with-exercise-induced-ventricular-ectopy
#20
Oguzhan Ekrem Turan, Mustafa Ozturk, Ibrahim Kocaoglu, Selen Gursoy Turan
Exercise-induced ventricular ectopy (EIVE) has clinical and prognostic significance. But the mechanism underlying EIVE-related mortality still remains unclear. This study aims to assess blood pressure alteration in patients with EIVE and to identify the potential causes of increased mortality in this patient group. A total number of 3611 patients were screened within a 1-year period, and patients with a structural heart disease, coronary artery disease, hypertension, diabetes mellitus, thyroid dysfunction, and chronic renal disease were excluded from the study...
May 2016: Journal of the American Society of Hypertension: JASH
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