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ventricular ectopy

C Guruchaithanya Kumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Francisco Contijoch, Srikant Kamesh Iyer, James J Pilla, Paul Yushkevich, Joseph H Gorman, Robert C Gorman, Harold Litt, Yuchi Han, Walter R T Witschey
PURPOSE: Develop self-gated MRI for distinct heartbeat morphologies in subjects with arrhythmias. METHODS: Golden angle radial data was obtained in seven sinus and eight arrhythmias subjects. An image-based cardiac navigator was derived from single-shot images, distinct beat types were identified, and images were reconstructed for repeated morphologies. Image sharpness, contrast, and volume variation were quantified and compared with self-gated MRI. Images were scored for image quality and artifacts...
August 31, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Alex Y Tan, Kenneth Ellenbogen
Idiopathic ventricular tachycardia is often considered a benign form of ventricular arrhythmia in patients without apparent structural heart disease. However, a subset of patients may develop malignant ventricular arrhythmias and present with syncope and sudden cardiac arrest. Survivors of cardiac arrest are candidates for implantable cardiac defibrillators (ICDs). The indications for ICDs in patients with less than a full-blown cardiac arrest presentation but with electrocardiographically high-risk ectopy features remain uncertain...
September 2016: Cardiac Electrophysiology Clinics
Nieves Gomez-Hurtado, Nicole J Boczek, Dmytro O Kryshtal, Christopher N Johnson, Jennifer Sun, Florentin R Nitu, Razvan L Cornea, Walter J Chazin, Melissa L Calvert, David J Tester, Michael J Ackerman, Björn C Knollmann
BACKGROUND: Calmodulin (CaM) mutations are associated with severe forms of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT). CaM mutations are found in 13% of genotype-negative long QT syndrome patients, but the prevalence of CaM mutations in genotype-negative CPVT patients is unknown. Here, we identify and characterize CaM mutations in 12 patients with genotype-negative but clinically diagnosed CPVT. METHODS AND RESULTS: We performed mutational analysis of CALM1, CALM2, and CALM3 gene-coding regions, in vitro measurement of CaM-Ca(2+) (Ca)-binding affinity, ryanodine receptor 2-CaM binding, Ca handling, L-type Ca current, and action potential duration...
August 2016: Circulation. Arrhythmia and Electrophysiology
Radek Frič, Per Kristian Eide
OBJECTIVE Several lines of evidence suggest common pathophysiological mechanisms in Chiari malformation Type I (CMI) and idiopathic intracranial hypertension (IIH). It has been hypothesized that tonsillar ectopy, a typical finding in CMI, is the result of elevated intracranial pressure (ICP) combined with a developmentally small posterior cranial fossa (PCF). To explore this hypothesis, the authors specifically investigated whether ICP is comparable in CMI and IIH and whether intracranial volumes (ICVs) are different in patients with CMI and IIH, which could explain the tonsillar ectopy in CMI...
June 24, 2016: Journal of Neurosurgery
Jan Novak, Alessandro Zorzi, Silvia Castelletti, Antonis Pantasis, Ilaria Rigato, Domenico Corrado, William Mckenna, Pier D Lambiase
AIMS: The differentiation between idiopathic right ventricular outflow tract (RVOT) arrhythmias and early arrhythmogenic right ventricular cardiomyopathy (ARVC) can be challenging. We aimed to assess whether QRS morphological features and coupling interval of ventricular ectopic beats (VEBs) can improve differentiation between the two conditions. METHODS AND RESULTS: Twenty desmosomal-gene mutation carriers (13 females, mean age 43 years) with no or mild ARVC phenotypic expression and 33 age- and sex-matched subjects with idiopathic RVOT arrhythmias were studied...
June 23, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Daniel Scherer, Claudia Seyler, Panagiotis Xynogalos, Eberhard P Scholz, Dierk Thomas, Johannes Backs, Martin Andrassy, Mirko Völkers, Christoph A Karle, Hugo A Katus, Edgar Zitron
BACKGROUND: Cardiac inwardly rectifying Kir current (IK1) mediates terminal repolarisation and is critical for the stabilization of the diastolic membrane potential. Its predominant molecular basis in mammalian ventricle is heterotetrameric assembly of Kir2.1 and Kir2.2 channel subunits. It has been shown that PKC inhibition of IK1 promotes focal ventricular ectopy. However, the underlying molecular mechanism has not been fully elucidated to date. METHODS AND RESULTS: In the Xenopus oocyte expression system, we observed a pronounced PKC-induced inhibition of Kir2...
2016: PloS One
Marcus Wieczorek, Reinhard Hoeltgen
BACKGROUND: Ventricular ectopy (VE) originating in the right ventricular outflow tract (RVOT) is a common arrhythmia. Mechanisms triggering or eliminating VE from RVOT are not entirely understood. CASE REPORT: A patient with frequent, symptomatic VE underwent an electrophysiologic study: VE origin was mapped by NavX 3D navigation. Incidental pressure applied manually to the sternum reproducibly eliminated VE for the time of exposure. RF-Ablation was successfully performed in the posterior RVOT...
May 16, 2016: Pacing and Clinical Electrophysiology: PACE
Stephen P Chelko, Angeliki Asimaki, Peter Andersen, Djahida Bedja, Nuria Amat-Alarcon, Deeptankar DeMazumder, Ravirasmi Jasti, Calum A MacRae, Remo Leber, Andre G Kleber, Jeffrey E Saffitz, Daniel P Judge
Arrhythmogenic cardiomyopathy (ACM) is characterized by redistribution of junctional proteins, arrhythmias, and progressive myocardial injury. We previously reported that SB216763 (SB2), annotated as a GSK3β inhibitor, reverses disease phenotypes in a zebrafish model of ACM. Here, we show that SB2 prevents myocyte injury and cardiac dysfunction in vivo in two murine models of ACM at baseline and in response to exercise. SB2-treated mice with desmosome mutations showed improvements in ventricular ectopy and myocardial fibrosis/inflammation as compared with vehicle-treated (Veh-treated) mice...
April 21, 2016: JCI Insight
Leroy C Joseph, Prakash Subramanyam, Christopher Radlicz, Chad M Trent, Vivek Iyer, Henry M Colecraft, John P Morrow
BACKGROUND: Diabetes and obesity are associated with an increased risk of arrhythmia and sudden cardiac death. Abnormal lipid accumulation is observed in cardiomyocytes of obese and diabetic patients, which may contribute to arrhythmia, but the mechanisms are poorly understood. A transgenic mouse model of cardiac lipid overload, the peroxisome proliferator-activated receptor-γ (PPARg) cardiac overexpression mouse, has long QT and increased ventricular ectopy. OBJECTIVE: The purpose of this study was to evaluate the hypothesis that the increase in ventricular ectopy during cardiac lipid overload is caused by abnormalities in calcium handling due to increased mitochondrial oxidative stress...
August 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Gabriela M Orgeron, Hugh Calkins
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy characterized by ventricular arrhythmias, right ventricular dysfunction, and sudden cardiac death. Since the first description of ARVD/C in 1982, there have been major advances in the diagnosis and management of the disease. For instance, the discovery of desmosomal abnormalities as a genetic basis for ARVD/C; the importance of proband status and ventricular ectopy for risk stratification of patients at risk for sudden cardiac death; and the critical role that exercise plays in the development and progression of ARVD/C, just to name a few...
June 2016: Current Cardiology Reports
Faisal F Syed, Michael J Ackerman, Christopher J McLeod, Suraj Kapa, Siva K Mulpuru, Chenni S Sriram, Bryan C Cannon, Samuel J Asirvatham, Peter A Noseworthy
BACKGROUND: Although the vast majority of mitral valve prolapse (MVP) is benign, a small subset of patients, predominantly women, with bileaflet prolapse, complex ventricular ectopy (VE), and abnormal T waves comprise the recently described bileaflet MVP syndrome. We compared findings on electrophysiological study in bileaflet MVP syndrome patients with and without cardiac arrest to identify factors that may predispose to malignant ventricular arrhythmia. METHODS AND RESULTS: Fourteen consecutive bileaflet MVP syndrome patients (n=13 women; median [limits], age at index ablation, 33...
May 2016: Circulation. Arrhythmia and Electrophysiology
Oguzhan Ekrem Turan, Mustafa Ozturk, Ibrahim Kocaoglu, Selen Gursoy Turan
Exercise-induced ventricular ectopy (EIVE) has clinical and prognostic significance. But the mechanism underlying EIVE-related mortality still remains unclear. This study aims to assess blood pressure alteration in patients with EIVE and to identify the potential causes of increased mortality in this patient group. A total number of 3611 patients were screened within a 1-year period, and patients with a structural heart disease, coronary artery disease, hypertension, diabetes mellitus, thyroid dysfunction, and chronic renal disease were excluded from the study...
May 2016: Journal of the American Society of Hypertension: JASH
Jennifer M Cavallari, Shona C Fang, Ellen A Eisen, Murray A Mittleman, David C Christiani
OBJECTIVES: Links between arrhythmias and particulate matter exposures have been found among sensitive populations. We examined the relationship between personal particulate matter ≤2.5 µm aerodynamic diameter (PM2.5) exposures and ectopy in a panel study of healthy welders. METHODS: Simultaneous ambulatory ECG and personal PM2.5 exposure monitoring with DustTrak Aerosol Monitor was performed on 72 males during work and non-work periods for 5-90 h (median 40 h)...
July 2016: Occupational and Environmental Medicine
George C Roush, Domenic A Sica
This review and update focuses on the clinical features of hydrochlorothiazide (HCTZ), the thiazide-like agents chlorthalidone (CTDN) and indapamide (INDAP), potassium-sparing ENaC inhibitors and aldosterone receptor antagonists, and loop diuretics. Diuretics are the second most commonly prescribed class of antihypertensive medication, and thiazide-related diuretics have increased at a rate greater than that of antihypertensive medications as a whole. The latest hypertension guidelines have underscored the importance of diuretics for all patients, but particularly for those with salt-sensitive and resistant hypertension...
October 2016: American Journal of Hypertension
Rachel Bastiaenen, Antonis Pantazis, Hanney Gonna, Irina Chis-Ster, Silvia Castelletti, Velislav N Batchvarov, Giulia Domenichini, Fabio Coccolo, Giuseppe Boriani, William J McKenna, Elijah R Behr, Mark M Gallagher
BACKGROUND: The ventricular ectopic QRS interval (VEQSI) has been shown to identify structural heart disease and predict mortality. In arrhythmogenic right ventricular cardiomyopathy (ARVC), early diagnosis is difficult using current methods, and life-threatening arrhythmias are common and difficult to predict. OBJECTIVE: The purpose of this study was to assess the utility of ventricular ectopic indices including VEQSI in ARVC diagnosis. METHODS: We studied 70 patients with ARVC [30 with definite disease (age 47 ± 12 years; 60% male), 40 with incomplete disease expression (age 44 ± 18 years; 44% male)], 116 healthy controls (age 40 ± 15 years; 56% male), and 26 patients with normal heart right ventricular outflow tract (RVOT) ectopy (age 46 ± 17 years; 27% male)...
July 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Francisco Contijoch, Kelly Rogers, Hannah Rears, Mohammed Shahid, Peter Kellman, Joseph Gorman, Robert C Gorman, Paul Yushkevich, Erica S Zado, Gregory E Supple, Francis E Marchlinski, Walter R T Witschey, Yuchi Han
BACKGROUND: Premature ventricular complexes (PVCs) are prevalent in the general population and are sometimes associated with reduced ventricular function. Current echocardiographic and cardiovascular magnetic resonance imaging techniques do not adequately address the effect of PVCs on left ventricular function. METHODS AND RESULTS: Fifteen subjects with a history of frequent PVCs undergoing cardiovascular magnetic resonance imaging had real-time slice volume quantification performed using a 2-dimensional (2D) real-time cardiovascular magnetic resonance imaging technique...
April 2016: Circulation. Arrhythmia and Electrophysiology
Zak Loring, Peter Hanna, Cara N Pellegrini
BACKGROUND: Frequent premature ventricular contractions (PVCs) can cause a reversible reduction in systolic function. Most studies use 24-hour ambulatory electrocardiograms (AECGs) to assess PVC burden; however, PVC counts vary across 24-hour periods. We hypothesized that extended AECG monitoring would better identify clinically significant ectopy. METHODS: All 14-day AECGs performed at the San Francisco Veterans Affairs Medical Center between 2012 and 2015 (N = 694) were reviewed, and individuals with PVC counts ≥1...
June 2016: Pacing and Clinical Electrophysiology: PACE
Kathleen A Hodgkinson, A J Howes, Paul Boland, Xiou Seegar Shen, Susan Stuckless, Terry-Lynn Young, Fiona Curtis, Ashley Collier, Patrick S Parfrey, Sean P Connors
BACKGROUND: We previously showed a survival benefit of the implantable cardioverter defibrillator (ICD) in males with arrhythmogenic right ventricular cardiomyopathy caused by a p.S358L mutation in TMEM43. We present long-term data (median follow-up 8.5 years) after ICD for primary (PP) and secondary prophylaxis in males and females, determine whether ICD discharges for ventricular tachycardia/ventricular fibrillation were equivalent to an aborted death, and assess relevant clinical predictors...
March 2016: Circulation. Arrhythmia and Electrophysiology
Liu Enzhao, Zhang Qitong, Xu Gang, Liu Tong, Ye Lan, Zhao Yanshu, Li Guangping
OBJECTIVE: Discrete potentials (DPs) have been recorded and targeted as the site of ablation of the outflow tract arrhythmias. The aim of the present study was to investigate the significance of DPs with respect to mapping and ablation for idiopathic outflow tract premature ventricular contractions (PVCs) or ventricular tachycardias (VTs). METHODS: Seventeen out of 24 consecutive patients with idiopathic right or left ventricular outflow tract PVCs/VTs who underwent radiofrequency catheter ablation between September 2012 and December 2013 in our department were included...
August 2015: Zhonghua Xin Xue Guan Bing za Zhi
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