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ventricular ectopy

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https://www.readbyqxmd.com/read/28884872/the-tip-of-the-muscle-is-a-dominant-location-of-ventricular-ectopy-originating-from-papillary-muscles-in-the-left-ventricle
#1
Petr Peichl, Jakub Baran, Dan Wichterle, Robert Čihák, Tomáš Skála, Bashar Aldhoon, Matevž Jan, Bor Antolič, Josef Kautzner
INTRODUCTION: Frequent ventricular premature complexes (VPCs) may cause symptoms and/or lead to deterioration of LV systolic function. Although frequent VPCs may be abolished by catheter ablation, it may be challenging in case of their origin from the LV papillary muscles (PMs). Our collaborative study aimed to analyze in detail the site of origin and the outcome of ablation. METHODS: Consecutive 34 patients (males: 68%; aged 62±12 years; LV ejection fraction: 50±9%) undergoing catheter ablation of VPCs originating from PMs were included...
September 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28794084/mechanically-induced-ectopy-via-stretch-activated-cation-nonselective-channels-is-caused-by-local-tissue-deformation-and-results-in-ventricular-fibrillation-if-triggered-on-the-repolarization-wave-edge-commotio-cordis
#2
T Alexander Quinn, Honghua Jin, Peter Lee, Peter Kohl
BACKGROUND: External chest impacts (commotio cordis) can cause mechanically induced premature ventricular excitation (PVEM) and, rarely, ventricular fibrillation (VF). Because block of stretch-sensitive ATP-inactivated potassium channels curtailed VF occurrence in a porcine model of commotio cordis, VF has been suggested to arise from abnormal repolarization caused by stretch activation of potassium channels. Alternatively, VF could result from abnormal excitation by PVEM, overlapping with normal repolarization-related electric heterogeneity...
August 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28791747/ecg-morphology-of-premature-ventricular-contractions-predicts-presence-of-myocardial-fibrotic-substrate-on-cardiac-magnetic-resonance-imaging-in-patients-undergoing-ablation
#3
Sabrina Oebel, Borislav Dinov, Arash Arya, Sebastian Hilbert, Philipp Sommer, Andreas Bollmann, Gerhard Hindricks, Ingo Paetsch, Cosima Jahnke
BACKGROUND: The most likely origin of PVCs may be deduced from surface ECG analysis while planning an electrophysiological study (EPS). Apart from purely benign forms of increased ventricular ectopy, myocardial substrate (e.g., regional fibrosis) may be present in certain cases, which will significantly impact the ablation approach. CMR imaging can reliably identify fibrotic target lesions and, hence, may assist in adequate patient selection and procedural planning. METHODS AND RESULTS: We analyzed 101 patients (59% male, mean age 57...
August 9, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28775064/ectopy-on-a-single-12-lead-ecg-incident-cardiac-myopathy-and-death-in-the-community
#4
Kaylin T Nguyen, Eric Vittinghoff, Thomas A Dewland, Jonathan W Dukes, Elsayed Z Soliman, Phyllis K Stein, John S Gottdiener, Alvaro Alonso, Lin Y Chen, Bruce M Psaty, Susan R Heckbert, Gregory M Marcus
BACKGROUND: Atrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12-lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12-lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality. METHODS AND RESULTS: We utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort...
August 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28752278/predictors-and-therapy-of-cardiomyopathy-caused-by-frequent-ventricular-ectopy
#5
REVIEW
Ghaith Sharaf Dabbagh, Frank Bogun
PURPOSE OF REVIEW: The aim of this review is to describe predictors and therapeutic principles for PVC-induced cardiomyopathy. RECENT FINDINGS: PVC-induced cardiomyopathy is a treatable condition resulting in a reversible form of cardiomyopathy. PVC-induced cardiomyopathy has only recently been recognized as an entity that causes a reversible form of cardiomyopathy. The mechanism of development of PVC-induced cardiomyopathy has not yet been elucidated, although dyssynchrony appears to play a major role...
September 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28739617/paediatric-chest-wall-trauma-causing-delayed-presentation-of-ventricular-arrhythmia
#6
Angela M Tegethoff, Emerald Raney, Jenny Mendelson, Michael R Minckler
This report describes a paediatric patient presenting with haemodynamically stable non-sustained ventricular tachycardia 1 day after minor blunt chest trauma. Initial laboratory studies, chest X-ray and echocardiography were normal; however, cardiac MRI revealed precordial haematoma, myocardial contusion and small pericardial effusion. Throughout her hospital course, she remained asymptomatic aside from frequent couplets and triplets of premature ventricular contractions. Ectopy was controlled with oral verapamil...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28705875/electrical-and-structural-substrate-of-arrhythmogenic-right-ventricular-cardiomyopathy-determined-using-noninvasive-electrocardiographic-imaging-and-late-gadolinium-magnetic-resonance-imaging
#7
Christopher M Andrews, Neil T Srinivasan, Stefania Rosmini, Heerajnarain Bulluck, Michele Orini, Sharon Jenkins, Antonis Pantazis, William J McKenna, James C Moon, Pier D Lambiase, Yoram Rudy
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a significant cause of sudden cardiac death in the young. Improved noninvasive assessment of ARVC and better understanding of the disease substrate are important for improving patient outcomes. METHODS AND RESULTS: We studied 20 genotyped ARVC patients with a broad spectrum of disease using electrocardiographic imaging (a method for noninvasive cardiac electrophysiology mapping) and advanced late gadolinium enhancement cardiac magnetic resonance scar imaging...
July 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28705548/age-dependent-ventricular-arrhythmias-risk-structural-and-molecular-remodeling-in-systemic-arterial-hypertension
#8
Alina Scridon, Rosa Doñate Puertas, Waheed Manati, Emmanuelle Fouilloux-Meugnier, Emmanuelle Loizon, Valérie Oréa, Bruno Chapuis, Claude Julien, Christian Barrès, Alain Tabib, Philippe Chevalier
INTRODUCTION: The left ventricular hypertrophy (LVH)-ventricular arrhythmias relationship associated with arterial hypertension and aging remains controversial. We aimed to assess the age-dependency of ventricular arrhythmias in spontaneously hypertensive rats (SHRs) and the corresponding ventricular structural and molecular remodeling. MATERIALS AND METHODS: Ventricular arrhythmias were quantified using 24-h radiotelemetry ECG monitoring in eight SHRs and four Wistar-Kyoto (WKY) rats at 14 (young), 24 (adult), and 48 (aging) weeks of age...
July 10, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28579517/early-regional-wall-distension-is-strongly-associated-with-vulnerability-to-ventricular-fibrillation-but-not-arrhythmia-triggers-following-coronary-occlusion-in-vivo
#9
José A Barrabés, Javier Inserte, Antonio Rodríguez-Sinovas, Marisol Ruiz-Meana, David Garcia-Dorado
Wall stress may favor ischemic ventricular arrhythmias, yet its association with ventricular fibrillation (VF) or ventricular ectopy has been inconsistent among studies and its potential arrhythmogenicity across the cardiac cycle is unclear. In 91 open-chest pigs undergoing 40-50 min left anterior descending artery occlusion, we assessed the association between diastolic or systolic distension of the ischemic area and the incidence of ventricular premature beats (VPBs) and VF. End-diastolic segment length (EDL) and systolic bulging ([maximum systolic length-EDL] × 100/EDL) were measured by ultrasonic crystals...
June 1, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28495433/ventricular-and-supraventricular-ectopy-in-subjects-with-early-repolarization
#10
MULTICENTER STUDY
Teresa Trenkwalder, Ryan King, Bernhard M Kaess, Christian Hengstenberg, Heribert Schunkert, Till Ittermann, Stephan B Felix, Mathias Busch, Marcus Dörr, Wibke Reinhard
Early repolarization (ER) is a common electrocardiographic (ECG) finding that is associated with an increased risk of idiopathic ventricular fibrillation and sudden cardiac death. This study investigated whether the presence of ER is a predictor of ventricular and supraventricular ectopy as a marker for electrical instability. Standard 12-lead electrocardiograms of the first follow-up in the population-based Study of Health in Pomerania (SHIP-1) (n = 3,300, age 20 to 79 years) were analyzed to identify subjects with an ER pattern...
July 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28495249/heart-rate-variability-to-monitor-performance-in-elite-athletes-criticalities-and-avoidable-pitfalls
#11
Daniela Lucini, Ilaria Marchetti, Antonio Spataro, Mara Malacarne, Manuela Benzi, Stefano Tamorri, Roberto Sala, Massimo Pagani
BACKGROUND: Spectral analysis of Heart Rate Variability (HRV) is a simple, non-invasive technique that is widely used in sport to assess sympatho-vagal regulation of the heart. Its employment is increasing partly due to the rising usage of wearable devices. However data acquisition using these devices may be suboptimal because they cannot discriminate between sinus and non-sinus beats and do not record any data regarding respiratory frequency. This information is mandatory for a correct clinical interpretation...
August 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28492868/efficacy-of-flecainide-in-the-treatment-of-catecholaminergic-polymorphic-ventricular-tachycardia-a-randomized-clinical-trial
#12
Prince J Kannankeril, Jeremy P Moore, Marina Cerrone, Silvia G Priori, Naomi J Kertesz, Pamela S Ro, Anjan S Batra, Elizabeth S Kaufman, David L Fairbrother, Elizabeth V Saarel, Susan P Etheridge, Ronald J Kanter, Michael P Carboni, Matthew V Dzurik, Darlene Fountain, Heidi Chen, E Wesley Ely, Dan M Roden, Bjorn C Knollmann
Importance: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal genetic arrhythmia syndrome characterized by polymorphic ventricular tachycardia with physical or emotional stress, for which current therapy with β-blockers is incompletely effective. Flecainide acetate directly suppresses sarcoplasmic reticulum calcium release-the cellular mechanism responsible for triggering ventricular arrhythmias in CPVT-but has never been assessed prospectively. Objective: To determine whether flecainide dosed to therapeutic levels and added to β-blocker therapy is superior to β-blocker therapy alone for the prevention of exercise-induced arrhythmias in CPVT...
July 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28472281/successful-catheter-ablation-of-ventricular-ectopy-in-a-young-patient-with-implanted-melody-valve
#13
Matevž Jan, David Žižek, Uroš Mazic, Luka Klemen, Gordan Mijovski, Petr Peichl
No abstract text is available yet for this article.
September 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28432194/diagnostic-value-of-prehospital-ecg-in-acute-stroke-patients
#14
Tobias Bobinger, Bernd Kallmünzer, Markus Kopp, Natalia Kurka, Martin Arnold, Stefan Heider, Stefan Schwab, Martin Köhrmann
OBJECTIVE: To investigate the diagnostic yield of prehospital ECG monitoring provided by emergency medical services in the case of suspected stroke. METHODS: Consecutive patients with acute stroke admitted to our tertiary stroke center via emergency medical services and with available prehospital ECG were prospectively included during a 12-month study period. We assessed prehospital ECG recordings and compared the results to regular 12-lead ECG on admission and after continuous ECG monitoring at the stroke unit...
May 16, 2017: Neurology
https://www.readbyqxmd.com/read/28431055/electrocardiographic-differentiation-of-idiopathic-right-ventricular-outflow-tract-ectopy-from-early-arrhythmogenic-right-ventricular-cardiomyopathy
#15
Jan Novak, Alessandro Zorzi, Silvia Castelletti, Antonis Pantasis, Ilaria Rigato, Domenico Corrado, William Mckenna, Pier D Lambiase
Aims: The differentiation between idiopathic right ventricular outflow tract (RVOT) arrhythmias and early arrhythmogenic right ventricular cardiomyopathy (ARVC) can be challenging. We aimed to assess whether QRS morphological features and coupling interval of ventricular ectopic beats (VEBs) can improve differentiation between the two conditions. Methods and Results: Twenty desmosomal-gene mutation carriers (13 females, mean age 43 years) with no or mild ARVC phenotypic expression and 33 age- and sex-matched subjects with idiopathic RVOT arrhythmias were studied...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28421842/the-management-of-ventricular-dysrhythmia-in-aconite-poisoning
#16
REVIEW
James M Coulson, Thomas M Caparrotta, John P Thompson
INTRODUCTION: Aconite poisoning is relatively rare but is frequently complicated by ventricular dysrhythmias, which may be fatal. Molecular basis of aconite alkaloid ventricular arrhythmogenicity: Aconite exerts its toxic effects due to the presence of an admixture of alkaloids present in all parts of the plant. The major target of these aconite alkaloids is the fast voltage-gates sodium channel, where they cause persistent activation. This blockade of the channel in the activated state promotes automaticity within the ventricular myocardium and the generation of ventricular arrhythmias...
June 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28401865/the-effect-of-mitral-valve-surgery-on-ventricular-arrhythmia-in-patients-with-bileaflet-mitral-valve-prolapse
#17
Niyada Naksuk, Faisal F Syed, Chayakrit Krittanawong, Mark J Anderson, Elisa Ebrille, Christopher V DeSimone, Vaibhav R Vaidya, Shiva P Ponamgi, Rakesh M Suri, Michael J Ackerman, Vuyisile T Nkomo, Samuel J Asirvatham, Peter A Noseworthy
BACKGROUND: Bileaflet mitral valve prolapse (biMVP) is associated with frequent ventricular ectopy (VE) and malignant ventricular arrhythmia. We examined the effect of mitral valve (MV) surgery on VE burden in biMVP patients. METHODS: We included 32 consecutive patients undergoing MV surgery for mitral regurgitation secondary to biMVP between 1993 and 2012 at Mayo Clinic who had available pre- and post-operative Holter monitoring data. Characteristics of patients with a significant reduction in postoperative VE (group A, defined as >10% reduction in VE burden compared to baseline) were compared with the rest of study patients (group B)...
November 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/28395912/dobutamine-stress-echocardiography-impact-of-abnormal-blood-potassium-levels-on-cardiac-arrhythmias
#18
Jared G Bird, Robert B McCully, Patricia A Pellikka, Garvan C Kane
BACKGROUND: Guidelines suggest that an abnormal blood potassium level is a relative contraindication to performing dobutamine stress echocardiography (DSE). However, this has not been previously studied. METHODS: We reviewed a consecutive series of patients who had potassium testing within 48 hours of undergoing DSE for the evaluation of myocardial ischemia over a 10-year period (N = 13,198). Normal potassium range in our laboratory is 3.6-5.2 mmol/L. Hemolyzed samples were not included...
April 7, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28388306/premature-ventricular-complex-is-more-prevalent-during-acute-exacerbated-than-stable-states-of-chronic-obstructive-pulmonary-disease-and-is-related-to-cardiac-troponin-t
#19
Gunnar Einvik, Rahul Bhatnagar, Nils Henrik Holmedahl, Anke Neukamm, Torbjørn Omland, Vidar Søyseth
During acute exacerbation of chronic obstructive pulmonary disease (AECOPD), myocardial stress may be aggravated. Sparse data exist concerning the prevalence and correlates of cardiac arrhythmias in the stable and exacerbated states of COPD. We hypothesized that AECOPD is associated with increased prevalence of cardiac arrhythmias independent of COPD-severity and co-morbidity, and explored possible mechanisms. A 24-hour Holter recording was obtained in 74 patients with stable COPD and 45 patients with AECOPD (mean age 54 years, 56% women)...
April 7, 2017: COPD
https://www.readbyqxmd.com/read/28336184/atrial-fibrillation-management-in-a-breeding-stallion
#20
N Heliczer, K Mitchell, O Lorello, J Dauvillier, D Burger, C C Schwarzwald, C Navas de Solis
A 20-year-old warmblood breeding stallion presented to a University practice for semen collection and evaluation was incidentally diagnosed with atrial fibrillation (AF). Electrocardiogram recordings during breeding revealed inappropriately rapid tachycardia and occasional ventricular premature depolarizations/aberrant ventricular conduction. Transvenous electrical cardioversion was performed. After successful cardioversion the horse displayed supraventricular ectopy and atrial contractile dysfunction and was administered sotalol hydrochloride in an attempt to decrease the risk of AF recurrence...
March 20, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
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