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https://www.readbyqxmd.com/read/29732567/catheter-ablation-of-papillary-muscle-arrhythmias-implications-of-mitral-valve-prolapse-and-systolic-dysfunction
#1
Adam Lee, Christian Hamilton Craig, Russell Denman, Haris M Haqqani
BACKGROUND: The left ventricular papillary muscles are important components of the mitral valve apparatus. Catheter ablation of ventricular arrhythmias from these sites is challenging. We aim to describe the association between LV papillary muscle ventricular arrhythmias (VAs) and mitral valve prolapse (MVP), and to determine the outcomes of ablation in these patients with a focus on those with MVP and cardiomyopathy. METHODS: 152 patients underwent 170 consecutive procedures for ablation of focal VAs...
May 6, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29720502/evaluation-of-the-impact-of-a-chronic-total-coronary-occlusion-on-ventricular-arrhythmias-and-long-term-mortality-in-patients-with-ischemic-cardiomyopathy-and-an-implantable-cardioverter-defibrillator-the-ectopy-in-icd-study
#2
Ivo M van Dongen, Dilek Yilmaz, Joëlle Elias, Bimmer E P M Claessen, Ronak Delewi, Reinoud E Knops, Arthur A M Wilde, Lieselot van Erven, Martin J Schalij, José P S Henriques
BACKGROUND: Previous studies report conflicting results about a higher incidence of ventricular arrhythmias in patients with a chronic total coronary occlusion (CTO). We aimed to investigate this association in a large cohort of implantable cardioverter defibrillator patients with long-term follow-up. METHODS AND RESULTS: All consecutive patients from 1992 onwards who underwent implantable cardioverter defibrillator implantation for ischemic cardiomyopathy at the Leiden University Medical Center were evaluated...
May 2, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29709577/endocardial-ablation-of-ventricular-ectopic-beats-arising-from-the-basal-infero-septal-process-of-the-left-ventricle
#3
Anthony Li, Zia Zuberi, Jason S Bradfield, John K Zarif, David E Ward, Robert H Anderson, Kalyanam Shivkumar, Magdi M Saba
BACKGROUND: Idiopathic VE shows predilection to sites within the left ventricular base such as the outflow tract/aortic sinuses, LV summit and adjacent to the aorto-mitral continuity. We characterize VE arising from the inferior septum of the LV base that were successfully managed by LV endocardial ablation from the infero-septal recess of the LV. OBJECTIVES: To determine the incidence, electrocardiographic, electrophysiological findings and anatomical features associated with ventricular ectopy (VE) arising from the basal infero-septal process of the left ventricle (ISP-LV) ablated using an LV endocardial approach via the infero-septal recess of the left ventricle...
April 27, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29707410/a-2-year-old-child-with-bilateral-ectopis-lentis-and-a-novel-fbn1-gene-variant-cys129ser
#4
Ahmed N Mohammad, Paldeep S Atwal
Marfan syndrome and dominant ectopia lentis are part of type 1 fibrillinopathies that are caused by FBN1 pathogenic variants. Making a diagnosis could be challenging due to the clinical overlap between these disorders. The revised Ghent criteria used for Marfan syndrome diagnosis helped in resolving some of the confusion, especially in younger children. We report on a case of bilateral ectopia lentis in a 2-year-old child with a normal echocardiogram. FBN1 sequencing revealed a novel likely pathogenic variant described as c...
June 2018: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/29697759/novel-concepts-and-approaches-in-ablation-of-atrial-fibrillation-the-role-of-non-pulmonary-vein-triggers
#5
Carola Gianni, Sanghamitra Mohanty, Chintan Trivedi, Luigi Di Biase, Andrea Natale
Ablation of non-pulmonary vein (PV) triggers is an important step to improve outcomes in atrial fibrillation ablation. Non-pulmonary vein triggers typically originates from predictable sites (such as the left atrial posterior wall, superior vena cava, coronary sinus, interatrial septum, and crest terminalis), and these areas can be ablated either empirically or after observing significant ectopy (with or without drug challenge). In this review, we will focus on ablation of non-PV triggers, summarizing the existing evidence and our current approach for their mapping and ablation...
April 25, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29675485/comparison-of-the-pregnancy-outcomes-between-the-medical-and-surgical-treatments-in-tubal-ectopi-pregnancy
#6
Azadeh Yousefnezhad, Azar Pirdehghan, Mahboubeh Roshandel Rad, Aemeh Eskandari, Shahnaz Ahmadi
Background: Various treatments have been proposed to treat ectopic pregnancy, but their impact on future pregnancies is still the subject of controversy. Objective: The aim of this study is to compare the medical and surgical treatment methods and their impact on the subsequent fertility results and complications in women with a history of ectopic pregnancy. Materials and Methods: In this analytical, cross-sectional study, 370 women with the history of ectopic pregnancy, (treared with single dose of methotrexate or salpingectomy by laparotomy), that referred to Al-Zahra Hospital, Rasht, Guilan between 2009 to 2013 were enrolled...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29671875/atrial-remodeling-and-ectopic-burden-in-recreational-athletes-implications-for-risk-of-atrial-fibrillation
#7
Adrian D Elliott, Rajiv Mahajan, Dominik Linz, Michael Stokes, Christian V Verdicchio, Melissa E Middeldorp, Andre La Gerche, Dennis H Lau, Prashanthan Sanders
BACKGROUND: Atrial remodeling, vagal tone and atrial ectopic triggers have been suggested to contribute to the increased incidence of atrial fibrillation (AF) in endurance athletes. How these parameters change with increased lifetime training hours is debated. HYPOTHESIS: We hypothesised that atrial remodeling occurs in proportion to total training history, thus contributing to the elevated risk of AF. METHODS: We recruited 99 recreational endurance athletes, subsequently grouped according to lifetime training hours, to undergo evaluation of atrial size, autonomic modulation and atrial ectopy...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29625195/idiopathic-premature-ventricular-complexes-originating-from-the-distal-great-cardiac-vein-clinical-cardiac-and-electrophysiological-characteristics-and-catheter-ablation-outcome
#8
Wenkui Lv, Xianhui Zhou, Gulinuer Yiming, Ling Zhang, Qina Zhou, Yaodong Li, Qiang Xing, Jianghua Zhang, Yanmei Lu, Hongli Wang, Guiqiu Cao, Baopeng Tang
AIMS: Although catheter ablation for idiopathic ventricular arrhythmia (VA) has been generally well-established, VA originating from the great cardiac vein (GCV) may be clinically challenging due to its epicardial origin, proximity to coronary arteries and limited accessibility. The purpose of this study was to explore its electrophysiological characteristics and identify effective mapping/ablation strategies for idiopathic premature ventricular complexes (PVCs) originating from the GCV...
April 3, 2018: Life Sciences
https://www.readbyqxmd.com/read/29618737/genome-wide-association-study-and-meta-analysis-identify-loci-associated-with-ventricular-and-supraventricular-ectopy
#9
Melanie D Napier, Nora Franceschini, Rahul Gondalia, James D Stewart, Raúl Méndez-Giráldez, Colleen M Sitlani, Amanda A Seyerle, Heather M Highland, Yun Li, Kirk C Wilhelmsen, Song Yan, Qing Duan, Jeffrey Roach, Jie Yao, Xiuqing Guo, Kent D Taylor, Susan R Heckbert, Jerome I Rotter, Kari E North, Alexander P Reiner, Zhu-Ming Zhang, Lesley F Tinker, Duanping Liao, Cathy C Laurie, Stephanie M Gogarten, Henry J Lin, Jennifer A Brody, Traci M Bartz, Bruce M Psaty, Nona Sotoodehnia, Elsayed Z Soliman, Christy L Avery, Eric A Whitsel
The genetic basis of supraventricular and ventricular ectopy (SVE, VE) remains largely uncharacterized, despite established genetic mechanisms of arrhythmogenesis. To identify novel genetic variants associated with SVE/VE in ancestrally diverse human populations, we conducted a genome-wide association study of electrocardiographically identified SVE and VE in five cohorts including approximately 43,000 participants of African, European and Hispanic/Latino ancestry. In thirteen ancestry-stratified subgroups, we tested multivariable-adjusted associations of SVE and VE with single nucleotide polymorphism (SNP) dosage...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29533494/immune-biomarkers-and-anti-hiv-activity-in-the-reproductive-tract-of-sexually-active-and-sexually-inactive-adolescent-girls
#10
Mimi Ghosh, Mariel Jais, Roshni Biswas, Jason Jarin, Jason Daniels, Christopher Joy, Monika Juzumaite, Vanessa Emmanuel, Veronica Gomez-Lobo
PROBLEM: Adolescent girls are disproportionately affected by the HIV/AIDS pandemic, accounting for 22% of all new HIV infections globally. Yet little is known regarding the immune microenvironment of the adolescent female reproductive tract, especially regarding differences among sexually active and inactive girls, a critical parameter to evaluate HIV susceptibility associated with young age and sexual debut. METHODS: Cervico-vaginal lavage (CVL) was collected from sexually active (10) and inactive (8) girls aged 11-19 years and analyzed by ELISA for inflammation-associated biomarkers IL-6, IL-8, TNF-α, MIP-3α, IL-1α, IL-1β, matrix metalloproteinases (MMP) 1, 2, 7, 8, and 9, as well as anti-HIV mediators, Elafin, SLPI, human beta-defensin 2, and tissue inhibitor of matrix metalloproteinases (TIMP) 1 and 2...
June 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29515227/structured-inpatient-evaluation-of-neonatal-cardiac-ectopy
#11
Irene A Hurst, Gregory Webster, Kerri Z Machut, Nina Gotteiner, Ahmad Sami Chaouki, Elizabeth N Groothuis, Karna Murthy
OBJECTIVE(S): In well-appearing newborns with suspected cardiac ectopy, we sought to evaluate our practice and test whether initial electrocardiogram (ECG) findings were associated with neonatal arrhythmias (NA). STUDY DESIGN: We identified well-appearing, non-anomalous infants >34 weeks' gestation with suspected ectopy over 3.5 years. NA was defined as ≥10% premature atrial contractions (PAC), ≥5 beats of atrial tachycardia, ≥2% premature ventricular contractions (PVCs), or ≥3 beats of ventricular tachycardia...
March 7, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29508083/ablation-approaches-for-ventricular-fibrillation
#12
REVIEW
Prabhpreet Singh, Amit Noheria
Invasive electrophysiology (EP) mapping and catheter ablation has increasingly become the standard of care for many cardiac arrhythmias like supraventricular tachycardias, atrial fibrillation, premature ventricular complexes (PVC), and monomorphic ventricular tachycardia. In this review, we discuss the recent progress made in the mapping and ablation of ventricular fibrillation (VF). Ventricular activation during VF is apparently disorganized, making mapping and interpretation difficult. Prolonged mapping during VF would require mechanical circulatory support as VF causes complete hemodynamic collapse...
March 6, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29506689/multifocal-atrial-and-ventricular-premature-contractions-with-an-increased-risk-of-dilated-cardiomyopathy-caused-by-a-na-v-1-5-gain-of-function-mutation-g213d
#13
Kirstine Calloe, Anders K Broendberg, Alex H Christensen, Lisbeth N Pedersen, Morten S Olesen, Maria de Los Angeles Tejada, Soren Friis, Morten B Thomsen, Henning Bundgaard, Henrik K Jensen
BACKGROUND: SCN5A mutations can lead to different cardiac diseases. Recently, SCN5A mutations have been linked to the clinical entity multifocal ectopic Purkinje-related premature contractions (MEPPC) characterized by ventricular ectopy and dilated cardiomyopathy. METHODS & RESULTS: A family with a uniform MEPPC-like phenotype, associated with complex atrial and ventricular arrhythmias and dilated cardiomyopathy caused by a high frequency of ventricular ectopy was clinically assessed...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29482954/ventricular-ectopy-in-the-context-of-left-ventricular-systolic-dysfunction-risk-factors-and-outcomes-following-catheter-ablation
#14
Adam Lee, Russell Denman, Haris M Haqqani
BACKGROUND: Ectopy-mediated cardiomyopathy (EMC) is a potentially reversible form of left ventricular systolic dysfunction. Various risk factors for the development of EMC have been proposed in the literature. We aim to assess medium term outcomes of focal ventricular arrhythmia (VA) ablation in the setting of cardiomyopathy (CMP) and to validate published risk factors for EMC. METHODS: Medium term recovery of left ventricular (LV) function and freedom from VA recurrence was assessed and compared between patients undergoing focal VA ablation in the setting of CMP and a control group with normal LV function...
February 12, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29414264/risk-stratification-for-sudden-cardiac-death-after-myocardial-infarction
#15
Jonathan W Waks, Alfred E Buxton
Sudden cardiac death (SCD) accounts for ∼50% of mortality after myocardial infarction (MI). Most SCDs result from ventricular tachyarrhythmias, and the tachycardias that precipitate cardiac arrest result from multiple mechanisms. As a result, it is highly unlikely that any single test will identify all patients at risk for SCD. Current guidelines for use of implantable cardioverter-defibrillators (ICDs) to prevent SCD are based primarily on measurement of left ventricular ejection fraction (LVEF). Although reduced LVEF is associated with increased total cardiac mortality after MI, the focus of current guidelines on LVEF omits ∼50% of patients who die suddenly...
January 29, 2018: Annual Review of Medicine
https://www.readbyqxmd.com/read/29408436/predicting-arrhythmic-risk-in-arrhythmogenic-right-ventricular-cardiomyopathy-a-systematic-review-and-meta-analysis
#16
Laurens P Bosman, Arjan Sammani, Cynthia A James, Julia Cadrin-Tourigny, Hugh Calkins, J Peter van Tintelen, Richard N W Hauer, Folkert W Asselbergs, Anneline S J M teRiele
While many studies evaluate predictors of ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy (ARVC), a systematic review consolidating this evidence is currently lacking. Therefore, we searched MEDLINE and Embase for studies analyzing predictors of ventricular arrhythmias (sustained ventricular tachycardia/fibrillation (VT/VF), appropriate implantable cardioverter-defibrillator therapy, or sudden cardiac death) in patients with definite ARVC, patients with borderline ARVC, and ARVC-associated mutation carriers...
February 3, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29319439/successful-management-of-minoxidil-toxicosis-in-a-dog
#17
Tyler J M Jordan, Page E Yaxley, Christine A Culler, Anusha Balakrishnan
CASE DESCRIPTION A 2-year-old sexually intact female mixed-breed dog was evaluated at an emergency hospital approximately 5 hours after ingestion of an unknown amount of over-the-counter topical hair growth promoter containing 5% minoxidil foam. Vomiting and signs of lethargy were reported by the owner, and physical examination revealed tachycardia and hypotension. No treatments were performed, and the dog was transferred to a veterinary referral hospital for management of suspected minoxidil toxicosis. CLINICAL FINDINGS On arrival at the referral hospital, the dog was tachycardic (heart rate, 200 to 220 beats/min) and hypotensive (systolic arterial blood pressure, 70 mm Hg)...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29276916/-intracellular-molecular-mechanisms-of-adrenergic-regulation-of-pulmonary-vein-myocardium-membrane-potential
#18
L V Rozenshtraukh, V M Karimova, V S Kuzmin
Pulmonary vein (PV) myocardium is characterized by numerous electrophysiological properties which make this tissue highly prone to spontaneous, ectopic activity partially due to resting potential (RP) instability. PV derived ectopy frequently underlies supraventricular arrhythmias, including atrial fibrillation. It has also been demonstrated that adrenergic stimulation causes proarrhythmic alterations in PV. Selective α1- and β-adrenoreceptors stimulation causes RP depolarization and hyperpolarization, respectively, at least in rats...
November 2017: Kardiologiia
https://www.readbyqxmd.com/read/29250249/arrhythmia-induced-cardiomyopathy-prevalent-under-recognized-reversible
#19
Rahul Dhawan, Rakesh Gopinathannair
Arrhythmia-induced cardiomyopathy (AIC) is a clinical condition in which a persistent tachyarrhythmia or frequent ectopy contribute to ventricular dysfunction leading to systolic heart failure. AIC can be partially or completely corrected with adequate treatment of the culprit arrhythmia. Several molecular and cellular alterations by which tachyarrhythmias lead to cardiomyopathy have been identified. AIC can affect children and adults, can be clinically silent in the form of asymptomatic tachycardia with cardiomyopathy, or can present with manifest heart failure...
October 2017: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/29238947/thyroid-ectopy-diagnostic-and-therapeutic-challenges-before-and-in-the-era-of-tsh-neonatal-screening
#20
REVIEW
Ewelina Szczepanek-Parulska, Aleksandra Hernik, Marek Ruchała
Despite TSH screening in newborns is currently conducted in most developed countries, patients with thyroid ectopy born before the procedure was introduced or those in whom the screening failed to establish diagnosis, might still appear. In the paper we revise the current state of knowledge regarding the clinical presentation, diagnosis and treatment of patients with thyroid ectopy. As an example, we report diagnostic and therapeutic difficulties in our three patients with thyroid ectopy remaining undiagnosed and untreated during early childhood...
2017: Endokrynologia Polska
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