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https://www.readbyqxmd.com/read/28302110/beneficial-effects-of-a-coriolus-versicolor-based-vaginal-gel-on-cervical-epithelization-vaginal-microbiota-and-vaginal-health-a-pilot-study-in-asymptomatic-women
#1
Santiago Palacios, Fernando Losa, Damián Dexeus, Javier Cortés
BACKGROUND: To assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide, Coriolus versicolor, Asian centella, Azadirachta indica and Aloe vera on vaginal microbiota, cervical epithelization and vaginal health. METHODS: Open-label, prospective pilot study conducted in asymptomatic women in daily practice. Cervical epithelization was evaluated by colposcopy using an ectopy epithelization score (from 5: no ectopy to 1: severe ectopy and bleeding), vaginal microbiota using the VaginaStatus-Diagnostic test (Instiüt für Mikroökologie, Herborn, Germany) and further rated by the investigator using a 5-point Liker scale (from 5: normal to 1: very severe deterioration in which all evaluated species were altered), and vaginal health using the Vaginal Health Index...
March 16, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28252842/effects-of-transendocardial-stem-cell-injection-on-ventricular-proarrhythmia-in-patients-with-ischemic-cardiomyopathy-results-from-the-poseidon-and-tac-hft-trials
#2
Archana Ramireddy, Chad R Brodt, Adam M Mendizabal, Darcy L DiFede, Chris Healy, Vishal Goyal, Yahya Alansari, James O Coffey, Juan F Viles-Gonzalez, Alan W Heldman, Jeffrey J Goldberger, Robert J Myerburg, Joshua M Hare, Raul D Mitrani
Transendocardial stem cell injection in patients with ischemic cardiomyopathy (ICM) improves left ventricular function and structure but has ill-defined effects on ventricular arrhythmias. We hypothesized that mesenchymal stem cell (MSC) implantation is not proarrhythmic. Post hoc analyses were performed on ambulatory ECGs collected from the POSEIDON and TAC-HFT trials. Eighty-eight subjects (mean age 61 ± 10 years) with ICM (mean EF 32.2% ± 9.8%) received treatment with MSC (n = 48), Placebo (n = 21), or bone marrow mononuclear cells (BMC) (n = 19)...
March 2, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28231562/corrigendum-to-prevalence-of-human-papillomavirus-genotypes-and-mucosal-iga-anti-viral-responses-in-women-with-cervical-ectopy-j-clin-virol-47-2010-43-48
#3
Olga L Monroy, Cecilia Aguilar, Marcela Lizano, Fernando Cruz-Talonia, Rosa M Cruz, Leticia Rocha-Zavaleta
No abstract text is available yet for this article.
April 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28223296/cardiac-effects-of-sulfonylurea-related-hypoglycemia
#4
Timothy L Middleton, Jencia Wong, Lynda Molyneaux, Belinda A Brooks, Dennis K Yue, Stephen M Twigg, Ted Wu
OBJECTIVE: To determine the effect of sulfonylurea-related hypoglycemia on cardiac repolarization and ectopy in the setting of well-controlled type 2 diabetes. RESEARCH DESIGN AND METHODS: Thirty subjects with sulfonylurea-treated type 2 diabetes underwent 48 h of concurrent continuous glucose monitoring and ambulatory electrocardiography. Ventricular repolarization (QTc) and QT dynamicity were analyzed during periods of hypoglycemia (<3.5 mmol/L for >20 min) and compared with periods of euglycemia and hyperglycemia combined...
February 21, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28215569/cardiac-phenotype-and-long-term-prognosis-of-arrhythmogenic-right-ventricular-cardiomyopathy-dysplasia-patients-with-late-presentation
#5
Aditya Bhonsale, Anneline S J M Te Riele, Abhishek C Sawant, Judith A Groeneweg, Cynthia A James, Brittney Murray, Crystal Tichnell, Thomas P Mast, Michelle J van der Pols, Maarten J M Cramer, Dennis Dooijes, Jeroen F van der Heijden, Harikrishna Tandri, J Peter van Tintelen, Daniel P Judge, Richard N W Hauer, Hugh Calkins
BACKGROUND: The clinical profile of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) patients with late presentation is unknown. OBJECTIVE: The purpose of this study was to characterize the genotype, cardiac phenotype, and long-term outcomes of ARVC/D patients with late presentation (age ≥50 years at diagnosis). METHODS: Five hundred two patients with an ARVC/D diagnosis from Johns Hopkins and Utrecht Registries were studied and long-term clinical outcomes ascertained...
February 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28213055/electrophysiological-measurements-that-can-explain-and-guide-temporary-accelerated-pacing-to-avert-re-occurrence-of-torsade-de-pointes-arrhythmias-in-the-canine-chronic-atrioventricular-block-model
#6
Sofieke C Wijers, Alexandre Bossu, Albert Dunnink, Jet D M Beekman, Rosanne Varkevisser, Alfonso Aranda Hernández, Mathias Meine, Marc A Vos
BACKGROUND: Pacing at higher rates is known to suppress torsade de pointes (TdP) arrhythmias. Nevertheless, exact application and mechanism need further clarification. In the anesthetized canine chronic atrioventricular block model, ventricular remodeling is responsible for a high and reproducible incidence of TdP upon a challenge with dofetilide. OBJECTIVE: We used this model to investigate by what mechanism accelerated pacing averts TdP and what repolarization parameter could be used to guide temporary accelerated pacing (TAP)...
February 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28174323/mild-hypokalemia-and-supraventricular-ectopy-increases-the-risk-of-stroke-in-community-dwelling-subjects
#7
Nick Mattsson, Preman Kumarathurai, Bjørn Strøier Larsen, Olav Wendelboe Nielsen, Ahmad Sajadieh
BACKGROUND AND PURPOSE: Stroke is independently associated with the common conditions of hypokalemia and supraventricular ectopy, and we hypothesize that the combination of excessive supraventricular ectopic activity and hypokalemia has a synergistic impact on the prognosis in terms of stroke in the general population. METHODS: Subjects (55-75 years old) from the Copenhagen Holter Study cohort (N=671) with no history of atrial fibrillation or stroke were studied-including baseline values of potassium and ambulatory 48-hour Holter monitoring...
February 7, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28170028/long-term-prognostic-significance-of-right-bundle-branch-morphology-ventricular-ectopy-induced-during-stress-test-in-patients-with-intermediate-to-high-probability-of-coronary-artery-disease
#8
Loïc Bière, Tin-Hinan Mezdad, Jean-Marc Dupuis, Laurent Vervueren, Hervé Rakotonirina, Fabrice Prunier, Alain Furber
No abstract text is available yet for this article.
February 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28159815/validation-of-the-prognostic-utility-of-the-electrocardiogram-for-acute-drug-overdose
#9
Alex F Manini, Ajith P Nair, Rajesh Vedanthan, David Vlahov, Robert S Hoffman
BACKGROUND: While it is certain that some emergency department patients with acute drug overdose suffer adverse cardiovascular events (ACVE), predicting ACVE is difficult. The prognostic utility of the ECG for heterogeneous drug overdose patients remains to be proven. This study was undertaken to validate previously derived features of the initial ECG associated with ACVE in this population. METHODS AND RESULTS: We performed a prospective validation cohort study to evaluate adult emergency department patients with acute drug overdose at 2 urban university hospitals over 5 years in whom an emergency department admission ECG was performed...
February 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28137981/sudden-cardiac-death-the-pro-arrhythmic-interaction-of-an-acute-loading-with-an-underlying-substrate
#10
George R Sutherland
Sudden cardiac death (SCD) is a complex phenomenon, occurring either in apparently normal individuals or in those where there is a recognized underlying cardiac abnormality. In both groups, the lethal arrhythmia has frequently been related to the physiologic trigger of either exercise or stress. Prior research into SCD has focused mainly on a combination of identifying either vulnerable myocardial substrates; pharmacological approaches to altering electrical activation/repolarisation in substrates; or the suppression of induced lethal arrhythmias with implantable defibrillators...
January 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28045723/rate-dependent-left-bundle-branch-block-in-an-ambulatory-surgery-patient-a-case-report
#11
Ashraf Farag, Justin Tsai, Sam Deeb, Deidre Putman-Garcia, John D Wasnick, Lydia A Conlay
A 52-year-old woman, ASA II (American Society of Anesthesia classification II) scheduled for cholecystectomy in an ambulatory center, exhibited a wide-complex tachycardia with ectopy on the monitor after induction with propofol and succinylcholine. Blood pressure remained stable; amiodarone was administered for presumed ventricular tachycardia. A 12-lead electrocardiogram (ECG) showed a new left bundle branch block (LBBB) at 98 beats per minute (bpm), which resolved when the heart rate slowed. Surgery was postponed, and both the LBBB and ectopy recurred frequently during the next 24 hours in the intensive care unit, particularly at heart rates >90 bpm...
February 15, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28011842/modelling-methodology-of-atrial-fibrosis-affects-rotor-dynamics-and-electrograms
#12
Caroline H Roney, Jason D Bayer, Sohail Zahid, Marianna Meo, Patrick M J Boyle, Natalia A Trayanova, Michel Haïssaguerre, Rémi Dubois, Hubert Cochet, Edward J Vigmond
AIMS: Catheter ablation is an effective technique for terminating atrial arrhythmia. However, given a high atrial fibrillation (AF) recurrence rate, optimal ablation strategies have yet to be defined. Computer modelling can be a powerful aid but modelling of fibrosis, a major factor associated with AF, is an open question. Several groups have proposed methodologies based on imaging data, but no comparison to determine which methodology best corroborates clinically observed reentrant behaviour has been performed...
December 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28011799/higher-burden-of-supraventricular-ectopic-complexes-early-after-catheter-ablation-for-atrial-fibrillation-is-associated-with-increased-risk-of-recurrent-atrial-fibrillation
#13
Christina Alhede, Arne Johannessen, Ulrik Dixen, Jan S Jensen, Pekka Raatikainen, Gerhard Hindricks, Håkan Walfridsson, Ole Kongstad, Steen Pehrson, Anders Englund, Juha Hartikainen, Peter S Hansen, Jens C Nielsen, Christian Jons
AIMS: Early identification of patients who could benefit from early re-intervention after catheter ablation is highly warranted. Our aim was to investigate the association between post-procedural burden of supraventricular ectopic complexes (SVEC) and the risk of long-term atrial fibrillation (AF) recurrence. METHODS AND RESULTS: A total of 125 patients undergoing catheter ablation for AF were included. Patients underwent 7-day Holter recordings immediately post-procedural...
December 23, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28001123/fine-scale-spatial-and-temporal-variation-in-temperature-and-arrhythmia-episodes-in-the-va-normative-aging-study
#14
Antonella Zanobetti, Brent A Coull, Itai Kloog, David Sparrow, Pantel S Vokonas, Diane R Gold, Joel Schwartz
Many studies have demonstrated that cold and hot temperatures are associated with increased deaths and hospitalization rates; new findings indicate also an association with more specific cardiac risk factors. Most of these existing studies have relied on few weather stations to characterize exposures; few have used residence-specific estimates of temperature, or examined the exposure-response function. We investigated the association of arrhythmia episodes with spatial and temporal variation in temperature...
January 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/27994873/submental-thyroid-ectopy-might-cause-subclinical-hypothyroidism-in-early-childhood
#15
Mirjana Kocova, Nikolina Zdraveska, Maja Zdravkovska, Violeta Anastasovska, Daniela Pop Gjorceva
OBJECTIVE: Thyroid ectopy is a rare condition resulting from abnormal embryologic development and migration of the gland. Sublingual is the most common thyroid ectopy; all other ectopic thyroid locations occur very rare. There are no reports in the literature that describe the clinical course of patients with congenital hypothyroidism due to thyroid ectopy. METHODS AND RESULTS: We present a child with congenital hypothyroidism detected on neonatal screening which had a subclinical course during follow-up...
2016: SAGE open medical case reports
https://www.readbyqxmd.com/read/27980762/catheter-ablation-of-ventricular-ectopy-with-para-hisian-origin-importance-of-mapping-both-sides-of-the-interventricular-septum-and-understanding-when-to-stop-ablating
#16
Antonio Madaffari, Anett Große, Santi Raffa, Markus Frommhold, Agnes Fink, J Christoph Geller
Catheter ablation of para-Hisian premature ventricular contractions (PVCs) still represents a challenge and is a compromise between success and inadvertent AV block. We describe a possible strategy to address PVCs from this location with high-amplitude His-bundle potentials at the site of earliest activation.
December 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27875987/biomarkers-of-cardiovascular-injury-and-stress-are-associated-with-increased-frequency-of-ventricular-ectopy-a-population-based-study
#17
Julia Brox Skranes, Gunnar Einvik, Silje Kjeka Namtvedt, Anna Randby, Harald Hrubos-Strøm, Jon Brynildsen, Tor-Arne Hagve, Virend K Somers, Helge Røsjø, Torbjørn Omland
BACKGROUND: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting...
November 22, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27867290/ranolazine-is-an-effective-and-safe-treatment-of-adults-with-symptomatic-premature-ventricular-contractions-due-to-triggered-ectopy
#18
Gary L Murray
Early and delayed afterdepolarizations (EAD/DAD) cause triggered ventricular ectopy. Because ranolazine (RAN) suppresses EAD/DAD, we postulated that RAN might be effective in reducing premature ventricular contractions (PVCs). To assess the effect of RAN in patients with symptomatic PVCs due to triggered ectopy and its safety and tolerability. A total of 59 patients with symptomatic PVCs were identified from full-disclosure Holters. Doses of 500 and 1,000 mg offlabel RAN, daily, were given to 34 and 66% patients, respectively, and repeat Holters were performed prospectively during mean followup of 3...
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27867071/evaluation-of-a-novel-high-resolution-mapping-system-for-catheter-ablation-of-ventricular-arrhythmias
#19
Karthik Viswanathan, Lilian Mantziari, Charles Butcher, Emily Hodkinson, Eric Lim, Habib Khan, Sandeep Panikker, Shouvik Haldar, Julian W E Jarman, David G Jones, Wajid Hussain, John P Foran, Vias Markides, Tom Wong
BACKGROUND: The mapping of ventricular arrhythmias in humans using a minibasket 64-electrode catheter paired with a novel automatic mapping system (Rhythmia) has not been evaluated. OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of mapping ventricular arrhythmias and clinical outcomes after ablation using this system. METHODS: Electroanatomic maps for ventricular arrhythmias were obtained during 20 consecutive procedures in 19 patients (12 with ventricular tachycardia [VT] and 2 with ventricular ectopy [VE])...
November 17, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27825535/thyroid-cancer-in-lingual-thyroid-and-thyroglossal-duct-cyst
#20
Giacomo Sturniolo, Francesco Vermiglio, Mariacarla Moleti
Ectopy is the most common embryogenetic defect of the thyroid gland, representing between 48 and 61% of all thyroid dysgeneses. Persistence of thyroid tissue in the context of a thyroglossal duct remnant and lingual thyroid tissue are the most common defects. Although most cases of ectopic thyroid are asymptomatic, any disease affecting the thyroid may potentially involve the ectopic tissue, including malignancies. The prevalence of differentiated thyroid carcinoma in lingual thyroid and thyroglossal duct cyst is around 1% of patients affected with the above thyroid ectopies...
November 4, 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
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