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https://www.readbyqxmd.com/read/29745501/-experimental-study-of-the-effects-of-sinotubular-junction-taper-on-artificial-bioprosthesis-valve-in-pulsatile-flow-condition
#1
Rongxi Jia, Yunfei Ma, Zhaoyong Gu, Youlian Pan, Sicong Liu, Aike Qiao, Chao Guo, Nianguo Dong, Xiaofeng Li, Yinglong Liu
The aim of the present experimental study is to determine the effects of sinotubular junction diameter on artificial bioprosthesis valves. An experimental study was performed for aortic root models with different sinotubular junction taper under pulsatile flow condition. The sinotubular junction diameters were modified to create four models with different sinotubular junction tapers with 0, 1, 3 and 5 degrees, respectively, using three dimensional printing techniques. After installing the testing bioprosthesis valve on the aortic root models, we conducted experiments of the pulsatile flow testing with different stroke volume in the pulsatile circulation simulation system...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29742737/inadvertent-defibrillator-lead-placement-into-the-left-ventricle-after-mitraclip-implantation-a-case-report
#2
Giuseppe Santarpia, Francesco Passafaro, Eugenia Pasceri, Annalisa Mongiardo, Antonio Curcio, Ciro Indolfi
RATIONALE: Inadvertent pacemaker/defibrillator lead placement into the left ventricle is an unusual cardiac device-related complication and its diagnosis is not always easy and often misunderstood. Thromboembolic events are frequently associated with this procedural complication. Percutaneous lead extraction should be performed when diagnosis is made early after device implantation while long-life oral anticoagulation is a wise option when the diagnosis is delayed and the lead is not removed...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29741488/long-term-durability-and-hemodynamic-performance-of-a-self-expanding-transcatheter-heart-valve-beyond-5-years-after-implantation-a-prospective-observational-study-applying-the-standardized-definitions-of-structural-deterioration-and-valve-failure
#3
Erik W Holy, Julia Kebernik, Mohammad Abdelghani, Simon F Stämpfli, Jens Hellermann, Abdelhakim Allali, Mohamed El-Mawardy, Susanne Sachse, Thomas F Lüscher, Felix C Tanner, Gert Richardt, Mohamed Abdel-Wahab
AIMS: Long-term results of transcatheter aortic valve implantation (TAVI), in particular the incidence of bioprosthetic valve failure (BVF), are uncertain. METHODS AND RESULTS: The study prospectively included all 152 patients who had undergone TAVI with the self-expanding CoreValve™ up to December 2011 at the Heart Center, Bad Segeberg, Germany. Late BVF (>30 days) was defined as either: 1) Severe structural valve deterioration (trans-prosthetic mean pressure gradient ≥40 mmHg and/or ≥20 mmHg rise from baseline OR severe intra-prosthetic aortic regurgitation), OR 2) Bioprosthetic valve dysfunction leading to death or re-intervention...
May 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29739020/how-do-transcatheter-heart-valves-fit-in-mitral-annuloplasty-rings-and-which-combination-can-be-recommended
#4
Roya Ostovar, Ralf-Uwe Kuehnel, Michael Erb, Martin Hartrumpf, Thomas Claus, Robert Haase, Johannes M Albes
BACKGROUND:  Transcatheter heart valve (THV) as valve-in-ring is increasingly used in the mitral position. Semi-rigid rings may serve as a more appropriate scaffold for proper anchoring of a THV as they may change from their oval to a round shape thereby fitting to the implanted THV. METHODS:  One rigid and five semi-rigid rings of four manufacturers, Edwards Physio I and II, Sorin 3D Memo, Medtronic Simulus, and St. Jude Medical (SJM) Saddle and SJM Sequin, with sizes 28 to 36 mm and Edwards Sapien III THV 23, 26, and 29 mm were used...
May 8, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29735584/bioprosthetic-aortic-valve-durability-in-the-era-of-transcatheter-aortic-valve-implantation
#5
REVIEW
Erwan Salaun, Marie-Annick Clavel, Josep Rodés-Cabau, Philippe Pibarot
The main limitation of bioprosthetic valves is their limited durability, which exposes the patient to the risk of aortic valve reintervention. Transcatheter aortic valve implantation (TAVI) is considered a reasonable alternative to surgical aortic valve replacement (SAVR) in patients with intermediate or high surgical risk. TAVI is now rapidly expanding towards the lower risk populations. Although the results of midterm durability of the transcatheter bioprostheses are encouraging, their long-term durability remains largely unknown...
May 7, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29727769/lymphocyte-and-monocyte-subpopulations-in-severe-aortic-stenosis-at-the-time-of-surgical-intervention
#6
Piotr Mazur, Aleksandra Mielimonka, Joanna Natorska, Ewa Wypasek, Bogusław Gawęda, Dorota Sobczyk, Przemysław Kapusta, Krzysztof Piotr Malinowski, Bogusław Kapelak
INTRODUCTION: Aortic stenosis (AS) is the most common acquired valvular heart disease in adults. Immune system involvement becomes evident during AS development. We sought to investigate the role of different circulating lymphocyte and monocyte subpopulations, with focus on CD4+ CD8+ and natural killer T (NKT) cells, in AS. MATERIAL AND METHODS: Blood samples and aortic valves were obtained from patients undergoing elective aortic valve surgery. Valves were dissected and underwent genetic analyses and calcium content assessment...
April 7, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29723533/early-degeneration-caused-by-cusp-tear-of-first-generation-trifecta-bioprosthesis
#7
Simone Eichinger, Akmal M A Badreldin, Walter B Eichinger
The Trifecta aortic valve has excellent hemodynamic performance as result of an expansive valve design with a bovine pericardial sheet externally mounted on a titanium stent. We report two cases of early Trifecta valve degeneration, both caused by partial rupture of one of the leaflet cusps three and four years post-implant. Post discharge, both patients had routinely performed echocardiography check-ups, without signs of valve failure. Transesophageal echocardiography performed while emergency hospital readmission due to severe dyspnea revealed transvalvular aortic regurgitation without signs of endocarditis...
April 30, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29705866/outcomes-with-a-latest-generation-self-expandable-intra-annular-re-sheathable-transcatheter-heart-valve-system-analysis-of-patients-with-impaired-left-ventricular-function-and-determinants-for-pacemaker-implantation
#8
Andreas Schaefer, Niklas Neumann, Matthias Linder, Niklas Schofer, Yvonne Schneeberger, Florian Deuschl, Gerhard Schoen, Stefan Blankenberg, Hermann Reichenspurner, Lenard Conradi, Ulrich Schäfer
OBJECTIVES: We herein report a single-center experience with the Portico TAVI system. Main focus was set on outcomes in patients with impaired left ventricular (LV) function and predictors for permanent pacemaker (PPM) implantation. METHODS: Between 05/2014 and 10/2017, 106 consecutive patients received TAVI using the Portico device. For comparison of patients with/without impaired LV function, and determination of multi-slice computed tomography and electrocardiogram correlates for PPM implantation subgroups were built (Subgroup I: LVEF ≥ 50%, n = 69, Subgroup II: LVEF < 50%, n = 37; Subgroup A: no PPM implantation, n = 89; Subgroup B: PPM implantation, n = 17)...
April 28, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29701384/endothelial-function-and-vascular-properties-in-severe-aortic-stenosis-before-and-after-aortic-valve-replacement-surgery
#9
Renata Melo, Francisca A Saraiva, Ana Filipa Ferreira, Soraia Moreira, Raquel Moreira, Rui J Cerqueira, Mário J Amorim, Paulo Pinho, André P Lourenço, Adelino F Leite-Moreira
INTRODUCTION: The degenerative process that results in aortic valve stenosis (AS) has pathophysiological features similar to the atherosclerotic process. We therefore hypothesized that, as in atherosclerosis, endothelial and vascular dysfunction could be a pathophysiologic feature of AS. AIM: To evaluate endothelial function before and after aortic valve replacement (AVR) surgery in patients with severe AS. To correlate endothelial function with severity of AS and clinical profile...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29688568/-aortic-stenosis-is-a-common-disease-which-requires-individualized-treatment
#10
Vendela Berglund, Gustav Mattsson, Peter Magnusson
Aortic stenosis is the most common valvular heart disease and the prevalence increases with age. Common symptoms include dyspnea, angina, and syncope. Echocardiography is a cornerstone in diagnosis of aortic stenosis. Severe aortic stenosis is defined as peak aortic jet velocity ≥4 m/s, a mean transvalvular gradient ≥40 mmHg, and/or an aortic valve area <1.0 cm2. The two-year mortality in patients with symptomatic aortic stenosis is 50 percent without intervention. The only efficient treatment is intervention, either open heart valve replacement or percutaneous transcatheter implantation of an aortic valve prosthesis (TAVI), which both provide symptomatic relief and improved survival...
April 23, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29617762/pressure-gradient-vs-flow-relationships-to-characterize-the-physiology-of-a-severely-stenotic-aortic-valve-before-and-after-transcatheter-valve-implantation
#11
Nils P Johnson, Jo M Zelis, Pim A L Tonino, Patrick Houthuizen, R Arthur Bouwman, Guus R G Brueren, Daniel T Johnson, Jacques J Koolen, Hendrikus H M Korsten, Inge F Wijnbergen, Frederik M Zimmermann, Richard L Kirkeeide, Nico H J Pijls, K Lance Gould
Aims: Echocardiography and tomographic imaging have documented dynamic changes in aortic stenosis (AS) geometry and severity during both the cardiac cycle and stress-induced increases in cardiac output. However, corresponding pressure gradient vs. flow relationships have not been described. Methods and results: We recruited 16 routine transcatheter aortic valve implantations (TAVI's) for graded dobutamine infusions both before and after implantation; 0.014″ pressure wires in the aorta and left ventricle (LV) continuously measured the transvalvular pressure gradient (ΔP) while a pulmonary artery catheter regularly assessed cardiac output by thermodilution...
April 2, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29608034/simulated-transcatheter-aortic-valve-flow-implications-of-elliptical-deployment-and-under-expansion-at-the-aortic-annulus
#12
Eric Sirois, Wenbin Mao, Kewei Li, Joseph Calderan, Wei Sun
Clinical use of transcatheter aortic valves (TAVs) has been associated with abnormal deployment, including oval deployment and under-expansion when placed into calcified aortic annuli. In this study, we performed an integrated computational and experimental investigation to quantify the impact of abnormal deployment at the aortic annulus on TAV hemodynamics. A size 23 mm generic TAV computational model, developed and published previously, was subjected to elliptical deployment at the annulus with eccentricity levels up to 0...
April 2, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29607162/early-and-mid-term-haemodynamic-performance-and-clinical-outcomes-of-st-jude-medical-trifecta%C3%A2-valve
#13
Renata Raimundo, Soraia Moreira, Francisca Saraiva, Rui J Cerqueira, Pedro Teixeira, Elson Salgueiro, André Lourenço, Mário J Amorim, Jorge Almeida, Paulo Pinho, Adelino F Leite-Moreira
Background: New models of aortic bioprostheses have proven excellent early haemodynamic profile, but their mid and long-term performance warrants further systematic assessment. The aim of this study is to report clinical and haemodynamic performance of St. Jude Medical Trifecta bioprosthesis during 5 years of implantation. Methods: We performed a single centre, retrospective, observational and descriptive study including all 556 individuals who underwent aortic valve replacement (AVR) with the Trifecta bioprosthesis (between July of 2011 and June of 2016)...
February 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29598861/rapid-deployment-versus-conventional-bioprosthetic-valve-replacement-for-aortic-stenosis
#14
Stephan Ensminger, Buntaro Fujita, Timm Bauer, Helge Möllmann, Andreas Beckmann, Raffi Bekeredjian, Sabine Bleiziffer, Sandra Landwehr, Christian W Hamm, Friedrich W Mohr, Hugo A Katus, Wolfgang Harringer, Thomas Walther, Christian Frerker
BACKGROUND: Surgical aortic valve replacement using conventional biological valves (CBVs) is the standard of care for treatment of old patients with aortic valve disease. Recently, rapid deployment valves (RDVs) have been introduced. OBJECTIVES: The purpose of this study was to report the nationwide German experience concerning RDVs for treatment of aortic valve stenosis and provide a head-to-head comparison with CBVs. METHODS: A total of 22,062 patients who underwent isolated surgical aortic valve replacement using CBV or RDV between 2011 and 2015 were enrolled into the German Aortic Valve Registry...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29598859/long-term-outcomes-following-surgical-aortic-bioprosthesis-implantation
#15
Tania Rodriguez-Gabella, Pierre Voisine, François Dagenais, Siamak Mohammadi, Jean Perron, Eric Dumont, Rishi Puri, Lluis Asmarats, Mélanie Côté, Sebastien Bergeron, Philippe Pibarot, Josep Rodés-Cabau
BACKGROUND: Few data exist on long-term outcomes and structural valve degeneration (SVD) in consecutive unselected patients undergoing surgical aortic valve replacement (SAVR). OBJECTIVES: The goal of this study was to determine the long-term outcomes of a contemporary cohort of consecutive unselected SAVR recipients with a focus on evaluating clinical outcomes and SVD based on echocardiographic criteria. METHODS: A total of 672 consecutive patients (mean age: 72 ± 8 years; 61...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29593835/assessing-the-risk-of-leaflet-motion-abnormality-following-transcatheter-aortic-valve-implantation
#16
Luca Testa, Azeem Latib
Leaflet motion abnormalities are a relatively new entity in the field of transcatheter aortic valve implantation and are associated with a range of different conditions, the extreme being prosthetic valve dysfunction with high gradients or central regurgitation and possibly early thrombotic degeneration. Another extreme condition is the incidental finding of leaflet thickening, but with normal transvalvular gradients. Transthoracic echocardiography is a useful screening tool for the detection of symptomatic thrombosis, but it has limited use in the detection of subclinical thrombosis and/or motion abnormalities alone...
January 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29593832/bioprosthetic-valve-fracture-during-valve-in-valve-tavr-bench-to-bedside
#17
John T Saxon, Keith B Allen, David J Cohen, Adnan K Chhatriwalla
Valve-in-valve (VIV) transcatheter aortic valve replacement (TAVR) has been established as a safe and effective means of treating failed surgical bioprosthetic valves (BPVs) in patients at high risk for complications related to reoperation. Patients who undergo VIV TAVR are at risk of patient-prosthesis mismatch, as the transcatheter heart valve (THV) is implanted within the ring of the existing BPV, limiting full expansion and reducing the maximum achievable effective orifice area of the THV. Importantly, patient-prosthesis mismatch and high residual transvalvular gradients are associated with reduced survival following VIV TAVR...
January 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29566812/transcatheter-aortic-valve-replacement-in-patients-with-low-flow-low-gradient-aortic-stenosis-the-topas-tavi-registry
#18
Henrique Barbosa Ribeiro, Stamatios Lerakis, Martine Gilard, João L Cavalcante, Raj Makkar, Howard C Herrmann, Stephan Windecker, Maurice Enriquez-Sarano, Asim N Cheema, Luis Nombela-Franco, Ignacio Amat-Santos, Antonio J Muñoz-García, Bruno Garcia Del Blanco, Alan Zajarias, John C Lisko, Salim Hayek, Vasilis Babaliaros, Florent Le Ven, Thomas G Gleason, Tarun Chakravarty, Wilson Y Szeto, Marie-Annick Clavel, Alberto de Agustin, Vicenç Serra, John T Schindler, Abdellaziz Dahou, Rishi Puri, Emilie Pelletier-Beaumont, Melanie Côté, Philippe Pibarot, Josep Rodés-Cabau
BACKGROUND: Few data exist on patients with low-flow, low-gradient aortic stenosis (LFLG-AS) undergoing transcatheter aortic valve replacement (TAVR). Also, very scarce data exist on the usefulness of dobutamine stress echocardiography (DSE) before TAVR in these patients. OBJECTIVES: The authors sought to evaluate clinical outcomes and changes in left ventricular ejection fraction (LVEF) following TAVR in patients with classical LFLG-AS. METHODS: This multicenter registry included 287 patients with LFLG-AS undergoing TAVR...
March 27, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29556145/sutureless-versus-conventional-aortic-valve-replacement-outcomes-in-70-high-risk-patients-undergoing-concomitant-cardiac-procedures
#19
Muhammet Onur Hanedan, Mehmet Ali Yuruk, Ali Ihsan Parlar, Ugur Ziyrek, Ali Kemal Arslan, Ufuk Sayar, Ilker Mataraci
In elderly, high-risk surgical patients, sutureless aortic valve replacement (AVR) can often be an alternative to conventional AVR; shorter aortic cross-clamp and cardiopulmonary bypass times are the chief advantages. We compared the outcomes of sutureless AVR with those of conventional AVR in 70 elderly patients who underwent concomitant cardiac surgical procedures. We retrospectively analyzed the cases of 42 men and 28 women (mean age, 70.4 ± 10.3 yr; range, 34-93 yr) who underwent cardiac operations plus AVR with either a sutureless valve (group 1, n=38) or a conventional bioprosthetic or mechanical valve (group 2, n=32)...
February 2018: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/29554265/prospective-multicentre-evaluation-of-a-novel-low-profile-transapical-delivery-system-for-self-expandable-transcatheter-aortic-valve-implantation-6-month-outcomes
#20
Lenard Conradi, Michael Hilker, Jörg Kempfert, Jochen Börgermann, Hendrik Treede, David M Holzhey, Holger Schröfel, Won-Keun Kim, Ulrich Schaefer, Thomas Walther
OBJECTIVES: We assessed the safety and efficacy of a novel low-profile, 22-Fr transapical delivery system together with the ACURATE neo™ resheathable transcatheter heart valve. METHODS: This prospective, single-arm, multicentre study enrolled 60 patients with severe symptomatic aortic stenosis and high surgical risk ineligible for transfemoral access. Primary end points were 6-month mortality and procedural success. RESULTS: The mean age of patients was 79...
March 14, 2018: European Journal of Cardio-thoracic Surgery
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