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Management of MDR TB

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https://www.readbyqxmd.com/read/28434936/defining-a-research-agenda-to-address-the-converging-epidemics-of-tuberculosis-and-diabetes-part-1-epidemiology-and-clinical-management
#1
REVIEW
Julia A Critchley, Blanca I Restrepo, Katharina Ronacher, Anil Kapur, Andrew A Bremer, Larry S Schlesinger, Randall Basaraba, Hardy Kornfeld, Reinout van Crevel
There is growing interest in the interaction between type 2 diabetes (DM) and tuberculosis (TB), but many research questions remain unanswered. Epidemiologists, basic scientists and clinical experts recently convened and identified priorities. This is the first of two reviews on this topic, summarising priority areas of research with regard to epidemiology, clinical management and public health. First, from an epidemiological point of view, more study is needed to determine the importance of transient hyperglycemia in TB patients, and on the importance of DM for the global epidemic of multi-drug resistant (MDR)-TB...
April 19, 2017: Chest
https://www.readbyqxmd.com/read/28425873/rapid-detection-of-mycobacterium-tuberculosis-and-rifampicin-resistance-in-extrapulmonary-tuberculosis-and-sputum-smear-negative-pulmonary-suspects-using-xpert-mtb-rif
#2
Irfan Ullah, Arshad Javaid, Haleema Masud, Mazhar Ali, Anila Basit, Waqas Ahmad, Faisal Younis, Rehana Yasmin, Afsar Khan, Abdul Jabbar, Masroor Husain, Zahid Ahmad Butt
BACKGROUND: Tuberculosis (TB) is a serious public health problem in developing countries such as Pakistan. Rapid diagnosis of TB and detection of drug resistance are very important for timely and appropriate management of multidrug-resistant TB (MDR-TB). OBJECTIVE: The purpose of this study was to determine the diagnostic efficacy of the Xpert MTB/RIF assay for rapid diagnosis of TB and detection of rifampicin (RIF) resistance in extrapulmonary and smear-negative pulmonary TB suspects...
April 21, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28399817/assessments-of-serum-copper-and-zinc-concentration-and-the-cu-zn-ratio-determination-in-patients-with-multidrug-resistant-pulmonary-tuberculosis-mdr-tb-in-c%C3%A3-te-d-ivoire
#3
Gnogbo Alexis Bahi, Lydie Boyvin, Souleymane Méité, Gervais Melaine M'Boh, Kadjowely Yeo, Kouassi Raymond N'Guessan, Alain Dit Philippe Bidié, Allico Joseph Djaman
BACKGROUND: In Côte d'Ivoire, multidrug-resistant tuberculosis (MDR-TB) is a serious public health problem with a prevalence estimated at 2.5% in 2006. Zinc and copper are essential Trace element needed to strengthen the immune system and also useful in the fight against tuberculosis. The Cu / Zn ratio is a good indicator of oxidative stress. The principal aim of this study was to evaluate the serum concentration of some trace element and determine the Cu / Zn ratio in patients with multidrug resistant pulmonary tuberculosis (MDR-TB) before and after second line treatment of TB...
April 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28361737/therapy-of-multidrug-resistant-and-extensively-drug-resistant-tuberculosis
#4
Barbara J Seaworth, David E Griffith
The global epidemic of multidrug-resistant tuberculosis (MDR-TB) caused by Mycobacterium tuberculosis strains resistant to at least isoniazid and rifampin was recently reported as larger than previously estimated, with at least 580,000 new cases reported in 2015. Extensively drug-resistant tuberculosis (XDR-TB), MDR-TB with additional resistance to a second-line fluoroquinolone and injectable, continues to account for nearly 10% of MDR cases globally. Cases in India, China, and the Russian Federation account for >45% of the cases of MDR-TB...
March 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28278406/multidrug-resistant-tuberculosis-in-the-northern-territory-a-10-year-retrospective-case-series
#5
Daniel Judge, Vicki Krause
BACKGROUND AND OBJECTIVE: To describe the clinical characteristics, risk factors, diagnostic modalities, treatments, subsequent outcomes and complications of Multidrug-resistant tuberculosis (MDR-TB) cases residing in the Northern Territory. METHODS: A retrospective case series was conducted of all patients treated for MDR-TB in the Northern Territory between 1 January 2004 and 31 December 2013. This is the first study to analyse data relating to the subset of MDR-TB cases treated in the Northern Territory...
September 30, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28256380/the-cursed-duet-today-tuberculosis-and-hiv-coinfection
#6
REVIEW
Simon Tiberi, Anna Cristina C Carvalho, Giorgia Sulis, Devan Vaghela, Adrian Rendon, Fernanda C de Q Mello, Ananna Rahman, Nashaba Matin, Ali Zumla, Emanuele Pontali
The tuberculosis (TB) and HIV syndemic continues to rage and are a major public health concern worldwide. This deadly association raises complexity and represent a significant barrier towards TB elimination. TB continues to be the leading cause of death amongst HIV-infected people. This paper reports the challenges that lay ahead and outlines some of the current and future strategies that may be able to address this co-epidemic efficiently. Improved diagnostics, cheaper and more effective drugs, shorter treatment regimens for both drug-sensitive and drug-resistant TB are discussed...
March 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28202091/isolation-unit-for-multidrug-resistant-tuberculosis-patients-in-a-low-endemic-country-a-step-towards-the-world-health-organization-end-tb-strategy
#7
M C Payen, J P VAN Vooren, O Vandenberg, N Clumeck, S DE Wit
Tuberculosis (TB) remains a threat to public health and is the second cause of death due to a single infectious agent after HIV/AIDS. The worldwide distribution of TB is heterogeneous. The incidence is decreasing in most high-income regions, but the situation remains worrying in many parts of the world. The emergence of Mycobacterium tuberculosis strains resistant to key agents used in treatment (rifampin and isoniazid) contributes to TB transmission around the world. To achieve TB elimination, both high and low endemic countries must upscale their efforts to decrease disease transmission and improve cure rates...
May 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28182570/long-term-outcome-and-safety-of-prolonged-bedaquiline-treatment-for-multidrug-resistant-tuberculosis
#8
Lorenzo Guglielmetti, Marie Jaspard, Damien Le Dû, Marie Lachâtre, Dhiba Marigot-Outtandy, Christine Bernard, Nicolas Veziris, Jérôme Robert, Yazdan Yazdanpanah, Eric Caumes, Mathilde Fréchet-Jachym
Bedaquiline, a recently approved drug for the treatment of multidrug-resistant tuberculosis (MDR-TB), is recommended for a duration of 24 weeks. There are scarce data on patients treated with this drug outside clinical trials.All MDR-TB patients who started treatment from January 1, 2011 to December 31, 2013 and received ≥30 days of bedaquiline were included in a multicentre observational cohort.Among 45 MDR-TB patients, 53% harboured isolates resistant to both fluoroquinolones and second-line injectables, and 38% harboured isolates resistant to one of these drug classes...
December 22, 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28157461/multidrug-resistant-tuberculosis-patients-views-of-interventions-to-reduce-treatment-loss-to-follow-up
#9
T Tupasi, A M C G Garfin, J M Mangan, R Orillaza-Chi, L C Naval, G I Balane, R Basilio, A Golubkov, E S Joson, W-J Lew, V Lofranco, M Mantala, S Pancho, J N Sarol, A Blumberg, D Burt, E V Kurbatova
SETTING: Patients who initiated treatment for multidrug-resistant tuberculosis (MDR-TB) at 15 Programmatic Management of Drug-resistant Tuberculosis (PMDT) health facilities in the Philippines between July and December 2012. OBJECTIVES: To describe patients' views of current interventions, and suggest changes likely to reduce MDR-TB loss to follow-up. METHODS: In-depth interviews were conducted between April and July 2014 with MDR-TB patients who were undergoing treatment, had finished treatment at the time of the interview (controls), or had been lost to follow-up (LTFU)...
January 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28110049/performance-of-microscopic-observation-drug-susceptibility-for-the-rapid-diagnosis-of-tuberculosis-and-detection-of-drug-resistance-in-bamako-mali
#10
M Sanogo, B Kone, B Diarra, M Maiga, B Baya, A M Somboro, Y S Sarro, A C G Togo, B P P Dembele, D Goita, A Kone, O M'Baye, N Coulibaly, S Diabate, B Traore, M H Diallo, Y I Coulibaly, P Saleeb, M Belson, S Orsega, S Siddiqui, M A Polis, S Dao, R L Murphy, S Diallo
OBJECTIVES: In Mali early detection and treatment of multidrug-resistant tuberculosis (MDR-TB) are still challenging due to the cost, time and/or complexity associated with regular tests. Microscopic Observation Drug Susceptibility (MODS) is a low-cost assay validated by WHO in 2010. It is a liquid-culture-based assay to detect the 'cording' characteristic of Mycobacterium tuberculosis complex and to assess susceptibility to both isoniazid and rifampicin defining multidrug-resistant tuberculosis (MDR-TB)...
January 18, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28068907/hospitalized-care-for-mdr-tb-in-port-harcourt-nigeria-a-qualitative-study
#11
Kingsley Lezor Bieh, Ralf Weigel, Helen Smith
BACKGROUND: In Nigeria multidrug-resistant tuberculosis (MDR-TB) is prevalent in 2.9% of new TB cases and 14% of retreatment cases, and the country is one of 27 with high disease burden globally. Patients are admitted and confined to one of ten MDR-TB treatment facilities throughout the initial 8 months of treatment. The perspectives of MDR-TB patients shared on social media and in academic research and those of providers are limited to experiences of home-based care. In this study we explored the views of hospitalised MDR-TB patients and providers in one treatment facility in Nigeria, and describe how their experiences are linked to accessibility of care and support services, in line with international goals...
January 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28057041/rifampicin-resistance-pattern-of-mycobacterium-tuberculosis-and-associated-factors-among-presumptive-tuberculosis-patients-referred-to-debre-markos-referral-hospital-ethiopia-a-cross-sectional-study
#12
Wondemagegn Mulu, Bayeh Abera, Mulat Yimer, Tadesse Hailu, Haimanot Ayele, Dereje Abate
BACKGROUND: Prevailing data on rifampicin-resistant M. tuberculosis is essential for early management of MDR-TB. Therefore, this study was conducted to determine the prevalence of rifampicin-resistant Mycobacterium tuberculosis and associated factors among presumptive TB cases in Debre Markos Referral Hospital, Ethiopia. METHODS: A cross-sectional study was conducted from September 2014 to March 2015. Detection of M. tuberculosis and resistance to rifampicin was performed using Gene Xpert MTB/RIF assay...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28043788/comparison-of-bacteriological-conversion-and-treatment-outcomes-among-mdr-tb-patients-with-and-without-diabetes-in-mexico-preliminary-data
#13
M Muñoz-Torrico, J Caminero Luna, G B Migliori, L D'Ambrosio, J L Carrillo-Alduenda, H Villareal-Velarde, A Torres-Cruz, H Flores-Ergara, D Martínez-Mendoza, C García-Sancho, R Centis, M Á Salazar-Lezama, R Pérez-Padilla
Diabetes mellitus (DM) is a well-known risk factor for tuberculosis (TB). However, it is not known to what extent DM affects the outcome in patients with multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB) treated with second-line anti-TB drugs. The objective of this study was to compare the microbiological evolution (sputum smear and culture conversion) and final outcomes of MDR/XDR-TB patients with and without DM, managed at the national TB reference centre in Mexico City. RESULTS: Ninety patients were enrolled between 2010 and 2015: 73 with MDR-TB (81...
December 30, 2016: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28043606/ethambutol-resistance-testing-by-mutation-detection-using-mtbdrsl
#14
H Margaryan, S Rüsch-Gerdes, A Hayrapetyan, A Mirzoyan
AIMS AND OBJECTIVES: Despite the successes in managing drug-susceptible TB, drug-resistant (DR) tuberculosis is a major challenge to the effectiveness of National Tuberculosis Program in Armenia, placing the country in the list of 18 high-burden countries for MDR-TB in the WHO European Region. Estimated burden of MDR-TB in 2012 was 9.4 (7-12) and 43 (38-49) among retreatment TB cases. A total of 92 laboratory confirmed cases had been reported to the WHO (57 new and 35 previously treated) out of 511 cases tested for MDR-TB...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043599/genetic-diversity-transmission-dynamics-and-drug-resistance-of-mycobacterium-tuberculosis-in-luanda-angola
#15
João Perdigão, Sofia Clemente, Jorge Ramos, Pedro Masakidi, Diana Machado, Carla Silva, Isabel Couto, Miguel Viveiros, Nuno Taveira, Isabel Portugal
OBJECTIVE/BACKGROUND: Despite the important role that the African region plays in a global tuberculosis (TB) epidemiological context, many countries in the region still lack data on the prevalence of specific Mycobacterium tuberculosis strains and drug resistance. This is the case for Angola, which presently lacks any data concerning drug-resistance rates and prevalence of specific M. tuberculosis genotypes and respective population structure. In this study, we made the first characterization of the genetic diversity and drug resistance of M...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043521/interleukin-10-gene-polymorphism-is-associated-with-multi-drug-resistant-tuberculosis-during-the-intensive-phase-of-standard-chemotherapy
#16
Butov Dmytro, Kuzhko Mykhailo, Butova Tetyana Kuzhko
OBJECTIVE/BACKGROUND: To study whether interleukin (IL)-10 gene polymorphism is associated with multi-drug resistant tuberculosis (MDR TB) during the intensive phase of standard chemotherapy. METHODS: The study comprised 170 individuals in Kharkiv region of Ukraine including 74 patients with pulmonary MDR TB (Group 1), 66 patients without MDR TB (Group 2), and 30 healthy donors (Group 3). Serum level of IL-10 was evaluated by enzyme-linked immunosorbent assay (pg/L)...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043502/genotypic-analysis-of-multidrug-resistant-tuberculosis-isolates-from-extra-pulmonary-tuberculosis-cases-in-tertiary-care-centers-in-northern-india
#17
Anand K Maurya, Vijaya L Nag, Surya Kant, Ramawadh S Kushwaha, Tapan N Dhole
OBJECTIVE/BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is a major public health problem. The diagnosis of MDR-TB is of paramount importance in establishing appropriate clinical management and infection control measures. Rapid detection of MDR-TB allows the establishment of an effective treatment regimen, minimizes the risk of further resistance, and limits the spread of drug-resistant strains. The aim of this study is to determine the genotypic characterization of MDR-TB isolates from extra pulmonary tuberculosis (EPTB) cases in tertiary care centers in Northern India...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/27998752/drug-resistant-tb-uk-multicentre-study-drums-treatment-management-and-outcomes-in-london-and-west-midlands-2008-2014
#18
Amber Arnold, Graham S Cooke, Onn Min Kon, Martin Dedicoat, Marc Lipman, Angela Loyse, Philip D Butcher, Irina Chis Ster, Thomas Stephen Harrison
OBJECTIVES: Detailed information regarding treatment practices and outcomes of MDR-TB treatment in the UK is required as a baseline for care improvements. METHODS: 100 consecutive cases between 2008 and 2014 were reviewed retrospectively at 4 MDR-TB treatment centres in England to obtain information on drug treatment choices, hospital admission duration and outcomes for MDR-TB. RESULTS: Initial hospital admission was long, median 62.5 (IQR 20-106, n = 92) days, and 13% (12/92) of patients lost their home during this period...
December 18, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27998730/tuberculosis-cases-caused-by-heterogeneous-infection-in-eastern-europe-and-their-influence-on-outcomes
#19
Irina Kontsevaya, Vladyslav Nikolayevskyy, Alexander Kovalyov, Olga Ignatyeva, Anna Sadykhova, Tatiana Simak, Olesya Tikhonova, Yulia Dubrovskaya, Edita Vasiliauskiene, Edita Davidaviciene, Girts Skenders, Olga Makurina, Yanina Balabanova, Francis Drobniewski
INTRODUCTION: Mycobacterium tuberculosis superinfection is known to occur in areas with high rates of tuberculosis (TB) and has a significant impact on overall clinical TB management. AIM: We aimed to estimate the superinfection rate in cohorts of drug sensitive and multi-drug resistant tuberculosis (MDR TB) patients from Eastern Europe and the potential role of a second MDR TB strain infecting a patient with active non-MDR TB in treatment outcome. METHODS: The study population included 512 serial M...
December 18, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27979786/exploring-tuberculosis-by-molecular-tests-on-dna-isolated-from-smear-microscopy-slides
#20
REVIEW
Niaina Rakotosamimanana, Marie Sylvianne Rabodoarivelo, Juan Carlos Palomino, Anandi Martin, Voahangy Rasolofo Razanamparany
Tuberculosis (TB) is an infectious disease of global public health importance caused by Mycobacterium tuberculosis complex. The disease has worsened with the emergence of multidrug-resistant (MDR)-TB strains. The timely diagnosis and treatment of TB remains a key public health priority, and laboratories have a critical role in the rapid and accurate detection of TB and drug resistance. Molecular assays based on nucleic acid amplification techniques have been developed for the rapid, sensitive, and specific diagnosis of TB, with the ability to determine the drug sensitivity status...
December 12, 2016: International Journal of Infectious Diseases: IJID
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