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https://www.readbyqxmd.com/read/28726884/lithium-dendrite-growth-mechanisms-in-polymer-electrolytes-and-prevention-strategies
#1
Pallab Barai, Kenneth Higa, Venkat Srinivasan
Future lithium-ion batteries must use lithium metal anodes to fulfill the demands of high energy density applications with the potential to enable affordable electric cars with 350-mile range. However, dendrite growth during charging prevents the commercialization of this technology. It has been demonstrated that the presence of a compressive mechanical stress field around a dendritic protrusion prevents growth. Several techniques based on this concept, such as protective layers, externally applied pressure and solid electrolytes have been investigated by other researchers...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28725940/construction-of-the-first-high-density-genetic-linkage-map-and-analysis-of-quantitative-trait-loci-for-growth-related-traits-in-sinonovacula-constricta
#2
Donghong Niu, Yunchao Du, Ze Wang, Shumei Xie, Haideng Nguyen, Zhiguo Dong, Heding Shen, Jiale Li
The razor clam (Sinonovacula constricta) is an important aquaculture species, for which a high-density genetic linkage map would play an important role in marker-assisted selection (MAS). In this study, we constructed a high-density genetic map and detected quantitative trait loci (QTLs) for Sinonovacula constricta with an F1 cross population by using the specific locus amplified fragment sequencing (SLAF-seq) method. A total of 315,553 SLAF markers out of 467.71 Mreads were developed. The final linkage map was composed of 7516 SLAFs (156...
July 19, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28724077/physical-map-of-the-short-arm-of-bread-wheat-chromosome-3d
#3
Kateřina Holušová, Jan Vrána, Jan Šafář, Hana Šimková, Barbora Balcárková, Zeev Frenkel, Benoit Darrier, Etienne Paux, Federica Cattonaro, Helene Berges, Thomas Letellier, Michael Alaux, Jaroslav Doležel, Jan Bartoš
Bread wheat ( L.) is one of the most important crops worldwide. Although a reference genome sequence would represent a valuable resource for wheat improvement through genomics-assisted breeding and gene cloning, its generation has long been hampered by its allohexaploidy, high repeat content, and large size. As a part of a project coordinated by the International Wheat Genome Sequencing Consortium (IWGSC), a physical map of the short arm of wheat chromosome 3D (3DS) was prepared to facilitate reference genome assembly and positional gene cloning...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724072/genome-wide-analysis-of-tar-spot-complex-resistance-in-maize-using-genotyping-by-sequencing-snps-and-whole-genome-prediction
#4
Shiliang Cao, Alexander Loladze, Yibing Yuan, Yongsheng Wu, Ao Zhang, Jiafa Chen, Gordon Huestis, Jingsheng Cao, Vijay Chaikam, Michael Olsen, Boddupalli M Prasanna, Felix San Vicente, Xuecai Zhang
Tar spot complex (TSC) is one of the most destructive foliar diseases of maize ( L.) in tropical and subtropical areas of Central and South America, causing significant grain yield losses when weather conditions are conducive. To dissect the genetic architecture of TSC resistance in maize, association mapping, in conjunction with linkage mapping, was conducted on an association-mapping panel and three biparental doubled-haploid (DH) populations using genotyping-by-sequencing (GBS) single-nucleotide polymorphisms (SNPs)...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28722536/travel-burden-associated-with-granulocyte-colony-stimulating-factor-administration-in-a-medicare-aged-population-a-geospatial-analysis
#5
J Mark Stephens, Mark Bensink, Charles Bowers, Christopher S Hollenbeak
OBJECTIVE: Prophylaxis with granulocyte colony-stimulating factors (G-CSFs) is recommended for patients receiving myelosuppressive chemotherapy regimens with a high risk of febrile neutropenia (FN). G-CSFs should be administered starting the day after chemotherapy, necessitating return trips to the oncology clinic at the end of each cycle. We examined the travel burden related to prophylactic G-CSF injections after chemotherapy in the United States (US). METHODS: We used 2012-2014 Medicare claims data to identify a national cohort of beneficiaries age 65+ with non-myeloid cancers who received both chemotherapy and prophylactic G-CSFs...
July 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28721729/impact-of-cl-doping-on-electrochemical-performance-in-orthosilicate-li2fesio4-a-dft-supported-experimental-approach
#6
Shivani Singh, Anish K Raj, Raja Sen, Priya Johari, Sagar Mitra
Safe and high capacity cathode materials are a long quest for commercial lithium-ion battery development. Among various searched cathode materials, Li2FeSiO4 has taken the attention due to optimal working voltage, high elemental abundance, and low toxicity. However, as per our understanding and observation, the electrochemical performance of this material is significantly limited by the intrinsic low electronic conductivity and slow lithium-ion diffusion, which limits the practical capacity (theoretical ~ 330 mAh g-1)...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718202/patterns-of-mortality-in-a-montane-mixed-conifer-forest-in-san-diego-county-california
#7
Mary Pyott Freeman, Douglas A Stow, Li An
We examine spatial patterns of conifer tree mortality and their changes over time for the montane mixed-conifer forests of San Diego County. These forest areas have recently experienced extensive tree mortality due to multiple factors. A spatial contextual image processing approach was utilized with high spatial resolution digital airborne imagery to map dead trees for the years 1997, 2000, 2002, and 2005 for three study areas: Palomar, Volcan, and Laguna mountains. Plot-based fieldwork was conducted to further assess mortality patterns...
July 17, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28716700/role-of-entrainment-in-the-era-of-high-density-activation-mapping-for-characterizing-the-reentrant-circuit
#8
EDITORIAL
Pasquale Santangeli, Sanjay Dixit
No abstract text is available yet for this article.
July 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28710774/ucsf-chimerax-meeting-modern-challenges-in-visualization-and-analysis
#9
Thomas D Goddard, Conrad C Huang, Elaine C Meng, Eric F Pettersen, Gregory S Couch, John H Morris, Thomas E Ferrin
UCSF ChimeraX is next-generation software for the visualization and analysis of molecular structures, density maps, 3D microscopy, and associated data. It addresses challenges in the size, scope, and disparate types of data attendant with cutting-edge experimental methods, while providing advanced options for high-quality rendering (interactive ambient occlusion, reliable molecular surface calculations, etc.) and professional approaches to software design and distribution. This paper highlights some specific advances in the areas of visualization and usability, performance, and extensibility...
July 14, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28710433/high-density-genetic-linkage-map-construction-and-quantitative-trait-locus-mapping-for-hawthorn-crataegus-pinnatifida-bunge
#10
Yuhui Zhao, Kai Su, Gang Wang, Liping Zhang, Jijun Zhang, Junpeng Li, Yinshan Guo
Genetic linkage maps are an important tool in genetic and genomic research. In this study, two hawthorn cultivars, Qiujinxing and Damianqiu, and 107 progenies from a cross between them were used for constructing a high-density genetic linkage map using the 2b-restriction site-associated DNA (2b-RAD) sequencing method, as well as for mapping quantitative trait loci (QTL) for flavonoid content. In total, 206,411,693 single-end reads were obtained, with an average sequencing depth of 57× in the parents and 23× in the progeny...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708892/cross-recognition-of-a-pit-viper-crotalinae-polyspecific-antivenom-explored-through-high-density-peptide-microarray-epitope-mapping
#11
Mikael Engmark, Bruno Lomonte, José María Gutiérrez, Andreas H Laustsen, Federico De Masi, Mikael R Andersen, Ole Lund
Snakebite antivenom is a 120 years old invention based on polyclonal mixtures of antibodies purified from the blood of hyper-immunized animals. Knowledge on antibody recognition sites (epitopes) on snake venom proteins is limited, but may be used to provide molecular level explanations for antivenom cross-reactivity. In turn, this may help guide antivenom development by elucidating immunological biases in existing antivenoms. In this study, we have identified and characterized linear elements of B-cell epitopes from 870 pit viper venom protein sequences by employing a high-throughput methodology based on custom designed high-density peptide microarrays...
July 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28708393/selective-deamination-of-mutagens-by-a-mycobacterial-enzyme
#12
Vandana Gaded, Ruchi Anand
Structure-based methods are powerful tools that are being exploited to unravel new functions with therapeutic advantage. Here, we report the discovery of a new class of deaminases, predominantly found in mycobacterial species that act on the commercially important s-triazine class of compounds. The enzyme, Msd from Mycobacterium smegmatis was taken as a representative candidate from an evolutionarily conserved sub-group that possesses high density of Mycobacterium deaminases. Biochemical investigation reveals that Msd specifically acts on mutagenic nucleobases like 5-azacytosine and isoguanine, and does not accept natural bases as substrates...
July 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28708060/synem-automated-synapse-detection-for-connectomics
#13
Benedikt Staffler, Manuel Berning, Kevin M Boergens, Anjali Gour, Patrick van der Smagt, Moritz Helmstaedter
Nerve tissue contains a high density of chemical synapses, about 1 per µm(3) in the mammalian cerebral cortex. Thus, even for small blocks of nerve tissue, dense connectomic mapping requires the identification of millions to billions of synapses. While the focus of connectomic data analysis has been on neurite reconstruction, synapse detection becomes limiting when datasets grow in size and dense mapping is required. Here, we report SynEM, a method for automated detection of synapses from conventionally en-bloc stained 3D electron microscopy image stacks...
July 14, 2017: ELife
https://www.readbyqxmd.com/read/28707382/neutron-crystallographic-studies-of-t4-lysozyme-at-cryogenic-temperature
#14
Le Li, Shantanu Shukla, Flora Meilleur, Robert F Standaert, Josh Pierce, Dean A A Myles, Matthew J Cuneo
Bacteriophage T4 lysozyme (T4L) has been used as a paradigm for seminal biophysical studies on protein structure, dynamics and stability. Approximately 700 mutants of this protein and their complexes have been characterized by X-ray crystallography; however, despite the high resolution diffraction limits attained in several studies, no hydrogen atoms were reported being visualized in the electron density maps. To address this, a 2.2 Å-resolution neutron data set was collected at 80 K from a crystal of perdeuterated T4L pseudo-wild type...
July 13, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28705876/demonstration-of-persistent-conduction-across-the-mitral-isthmus-via-the-vein-of-marshall-with-high-density-activation-mapping
#15
Nathaniel Thompson, Takeshi Kitamura, Ruairidh Martin, Nicolas Derval, Arnaud Denis, Pierre Jaïs
No abstract text is available yet for this article.
July 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28703042/genome-wide-association-mapping-of-fusarium-head-blight-resistance-in-spring-wheat-lines-developed-in-the-pacific-northwest-and-cimmyt
#16
Rui Wang, Jianli Chen, James A Anderson, Junli Zhang, Weidong Zhao, Justin Wheeler, Natalie Klassen, Deven R See, Yanhong Dong
Fusarium head blight is a destructive disease of wheat in humid and semi-humid areas of the world. It has emerged in the Pacific Northwest (PNW) in recent years because of changing climate and crop rotation practices. Our objectives in the present study were to identify and characterize QTL associated with FHB resistance in spring wheat lines developed in the PNW and the International Maize and Wheat Improvement Center (CIMMYT). A total of 170 spring wheat lines were evaluated in field and greenhouse trials in 2015 and 2016...
July 13, 2017: Phytopathology
https://www.readbyqxmd.com/read/28702349/distinct-multivariate-brain-morphological-patterns-and-their-added-predictive-value-with-cognitive-and-polygenic-risk-scores-in-mental-disorders
#17
Nhat Trung Doan, Tobias Kaufmann, Francesco Bettella, Kjetil Nordbø Jørgensen, Christine Lycke Brandt, Torgeir Moberget, Dag Alnæs, Gwenaëlle Douaud, Eugene Duff, Srdjan Djurovic, Ingrid Melle, Torill Ueland, Ingrid Agartz, Ole A Andreassen, Lars T Westlye
The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is known about the complementary clinical value of brain structural phenotypes when combined with data on cognitive performance and genetic risk. Using data-driven fusion of cortical thickness, surface area, and gray matter density maps (GMD), we found six biologically meaningful patterns showing strong group effects, including four statistically independent multimodal patterns reflecting co-occurring alterations in thickness and GMD in patients, over and above two other independent patterns of widespread thickness and area reduction...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28698580/the-genetic-architecture-of-water-soluble-protein-content-and-its-genetic-relationship-to-total-protein-content-in-soybean
#18
Dan Zhang, Haiyan Lü, Shanshan Chu, Huairen Zhang, Hengyou Zhang, Yuming Yang, Hongyan Li, Deyue Yu
Water-soluble protein content (WSPC) is a critical factor in both soybean protein quality and functionality. However, the underlying genetic determinants are unclear. Here, we used 219 soybean accessions and 152 recombinant inbred lines genotyped with high-density markers and phenotyped in multi-environments to dissect the genetic architectures of WSPC and protein content (PC) using single- and multi-locus genome-wide association studies. In the result, a total of 32 significant loci, including 10 novel loci, significantly associated with WSPC and PC across multi-environments were identified, which were subsequently validated by linkage mapping...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28697758/identification-of-qtls-controlling-grain-protein-concentration-using-a-high-density-snp-and-ssr-linkage-map-in-barley-hordeum-vulgare-l
#19
Chaofeng Fan, Huijie Zhai, Huifang Wang, Yafei Yue, Minghu Zhang, Jinghui Li, Shaozhe Wen, Ganggang Guo, Yawen Zeng, Zhongfu Ni, Mingshan You
BACKGROUND: Grain protein concentration (GPC) is a major determinant of quality in barley (Hordeum vulgare L.). Breeding barley cultivars with high GPC has practical value for feed and food properties. The aim of the present study was to identify quantitative trait loci (QTLs) for GPC that could be detected under multiple environments. RESULTS: A population of 190 recombinant inbred lines (RILs) deriving from a cross between Chinese landrace ZGMLEL with high GPC (> 20%) and Australian cultivar Schooner was used for linkage and QTL analyses...
July 11, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28696673/how-nothing-boosts-affinity-hydrophobic-ligand-binding-to-the-virtually-vacated-s1-pocket-of-thermolysin
#20
Stefan G Krimmer, Jonathan Cramer, Johannes Schiebel, Andreas Heine, Gerhard Klebe
We investigated the hydration state of the deep, well accessible hydrophobic S1' specificity pocket of the metalloprotease thermolysin with purposefully designed ligands using high-resolution crystallography and isothermal titration calorimetry. The S1' pocket is known to recognize selectively a very stringent set of aliphatic side chains such as valine, leucine and isoleucine of putative substrates. We engineered a weak-binding ligand covering the active site of the protease without addressing the S1' pocket, thus transforming it into an enclosed cavity...
July 11, 2017: Journal of the American Chemical Society
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