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high-density mapping

Takashi Kumagai, Janina N Ladenthin, Yair Litman, Mariana Rossi, Leonhard Grill, Sylwester Gawinkowski, Jacek Waluk, Mats Persson
Tautomerization in single porphycene molecules is investigated on Cu(111), Ag(111), and Au(111) surfaces by a combination of low-temperature scanning tunneling microscopy (STM) experiments and density functional theory (DFT) calculations. It is revealed that the trans configuration is the thermodynamically stable form of porphycene on Cu(111) and Ag(111), whereas the cis configuration occurs as a meta-stable form. The trans → cis or cis → trans conversion on Cu(111) can be induced in an unidirectional fashion by injecting tunneling electrons from the STM tip or heating the surface, respectively...
March 14, 2018: Journal of Chemical Physics
Katsuyuki Taguchi, Toshihide Itoh, Matthew K Fuld, Eric Fournie, Okkyun Lee, Kyo Noguchi
OBJECTIVES: A novel imaging technique ("X-map") has been developed to identify acute ischemic lesions for stroke patients using non-contrast-enhanced dual-energy computed tomography (NE-DE-CT). Using the 3-material decomposition technique, the original X-map ("X-map 1.0") eliminates fat and bone from the images, suppresses the gray matter (GM)-white matter (WM) tissue contrast, and makes signals of edema induced by severe ischemia easier to detect. The aim of this study was to address the following 2 problems with the X-map 1...
March 14, 2018: Investigative Radiology
Robin De Roover, Wouter Crijns, Kenneth Poels, Ronald Peeters, Cédric Draulans, Karin Haustermans, Tom Depuydt
PURPOSE: Liquid fiducial markers have shown to be a promising alternative to solid gold markers in terms of imaging artifact reduction, patient comfort and compatibility with different imaging modalities. This study aims to investigate the performance of the novel BioXmark® liquid marker for state-of-the-art multi-modal imaging used in prostate cancer (PCa) radiotherapy, encompassing kV CT/CBCT, multi-parametric MRI and kV X-ray imaging. In addition, automatic detection of the liquid markers in X-ray imaging for prostate motion monitoring during treatment was investigated...
March 14, 2018: Medical Physics
Takahiro Ohkuma, Kurt Kremer, Kostas Daoulas
Understanding properties of polymer alloys with computer simulations frequently requires equilibration of samples comprised of microscopically described long molecules. We present the extension of an efficient hierarchical backmapping strategy, initially developed for homopolymer melts, to equilibrate high-molecular-weight binary blends. These mixtures present significant interest for practical applications and fundamental polymer physics. In our approach, the blend is coarse-grained into models representing polymers as chains of soft blobs...
March 14, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Tianxiao Jiang, Su Liu, Giuseppe Pellizzer, Aydin Aydoseli, Sacit Karamursel, Pulat A Sabanci, Altay Sencer, Candan Gurses, Nuri F Ince
Functional mapping of eloquent cortex before the resection of a tumor is a critical procedure for optimizing survival and quality of life. In order to locate the hand area of the motor cortex in two patients with low-grade gliomas (LGG), we recorded electrocorticogram (ECoG) from a 113 channel hybrid high-density grid (64 large contacts with diameter of 2.7 mm and 49 small contacts with diameter of 1 mm) while they executed hand clenching movements. We investigated the spatio-spectral characteristics of the neural oscillatory activity and observed that, in both patients, the hand movements were consistently associated with a wide spread power decrease in the low frequency band (LFB: 8-32 Hz) and a more localized power increase in the high frequency band (HFB: 60-280 Hz) within the sensorimotor region...
2018: Frontiers in Neuroscience
Gene-Jack Wang, Jizheng Zhao, Dardo Tomasi, Ehsan Shokri Kojori, Ruiliang Wang, Corinde E Wiers, Elisabeth C Caparelli, Nora D Volkow
BACKGROUND: The control of food intake in environments with easy access to highly rewarding foods is challenging to most modern societies. The combination of sustained release (SR) naltrexone and SR bupropion (NB32) has been used in weight-loss and obesity management. However, the effects of NB32 on the brain circuits implicated in the regulation of food intake are unknown. Here we used functional connectivity density (FCD) mapping to evaluate the effects of NB32 on resting brain FC. METHODS: Thirty-six healthy women underwent magnetic resonance imaging (MRI) before and after 4-week treatment with NB32 (n = 16) or with placebo (n = 20)...
February 23, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Carlo Pappone, Giuseppe Ciconte, Gabriele Vicedomini, Jan O Mangual, Wenwen Li, Manuel Conti, Luigi Giannelli, Felicia Lipartiti, Luke McSpadden, Kyungmoo Ryu, Marco Guazzi, Lorenzo Menicanti, Vincenzo Santinelli
BACKGROUND: Clinical outcomes after ablation of persistent atrial fibrillation remain suboptimal. Identification of AF drivers using a novel integrated mapping technique may be crucial to ameliorate the clinical outcome. METHODS AND RESULTS: Persistent AF patients were prospectively enrolled to undergo high-density electrophysiological mapping to identify repetitive-regular activities (RRas) before modified circumferential pulmonary vein (PV) ablation. They have been randomly assigned (1:1 ratio) to ablation of RRa followed by modified circumferential PV ablation (mapping group; n=41) or modified circumferential PV ablation alone (control group; n=40)...
March 2018: Circulation. Arrhythmia and Electrophysiology
Claudio Toma, Alex D Shaw, Richard J N Allcock, Anna Heath, Kerrie D Pierce, Philip B Mitchell, Peter R Schofield, Janice M Fullerton
Bipolar disorder (BD) is a complex psychiatric condition with high heritability, the genetic architecture of which likely comprises both common variants of small effect and rare variants of higher penetrance, the latter of which are largely unknown. Extended families with high density of illness provide an opportunity to map novel risk genes or consolidate evidence for existing candidates, by identifying genes carrying pathogenic rare variants. We performed whole-exome sequencing (WES) in 15 BD families (117 subjects, of whom 72 were affected), augmented with copy number variant (CNV) microarray data, to examine contributions of multiple classes of rare genetic variants within a familial context...
March 13, 2018: Translational Psychiatry
Zixiang Wen, Ruijuan Tan, Shichen Zhang, Paul J Collins, Jiazheng Yuan, Wenyan Du, Cuihua Gu, Shujun Ou, Qijian Song, Yong-Qiang Charles An, John F Boyse, Martin I Chilvers, Dechun Wang
White mold of soybean, caused by Sclerotinia sclerotiorum (Lib.) de Bary, is a necrotrophic fungus capable of infecting a wide range of plants. To dissect the genetic architecture of resistance to white mold, a high-density customized single nucleotide polymorphism (SNP) array (52,041 SNPs) was used to genotype two soybean diversity panels. Combined with resistance variation data observed in the field and greenhouse environments, genome-wide association studies (GWAS) were conducted to identify quantitative trait loci (QTL) controlling resistance against white mold...
March 12, 2018: Plant Biotechnology Journal
Helena Verhelst, Catharine Vander Linden, Toon De Pauw, Guy Vingerhoets, Karen Caeyenberghs
Recent evidence has shown the presence of a "rich club" in the brain, which constitutes a core network of highly interconnected and spatially distributed brain regions, important for high-order cognitive processes. This study aimed to map the rich club organization in 17 young patients with moderate to severe TBI (15.71 ± 1.75 years) in the chronic stage of recovery and 17 age- and gender-matched controls. Probabilistic tractography was performed on diffusion weighted imaging data to construct the edges of the structural connectomes using number of streamlines as edge weight...
March 12, 2018: Human Brain Mapping
Battuya Bayarmagnai, Louisiane Perrin, Kamyar Esmaeili Pourfarhangi, Bojana Gligorijevic
Cancer cell motility and invasion are key features of metastatic tumors. Both are highly linked to tumor microenvironmental parameters, such as collagen architecture or macrophage density. However, due to the genetic, epigenetic and microenvironmental heterogeneities, only a small portion of tumor cells in the primary tumor are motile and furthermore, only a small portion of those will metastasize. This creates a challenge in predicting metastatic fate of single cells based on the phenotype they exhibit in the primary tumor...
2018: Methods in Molecular Biology
Yolanda Sánchez Sánchez, Antonio Martínez-Graña, Fernando Santos Francés, Marina Mateos Picado
Wildfire is a major threat to the environment, and this threat is aggravated by different climatic and socioeconomic factors. The availability of detailed, reliable mapping and periodic and immediate updates makes wildfire prevention and extinction work more effective. An analyst protocol has been generated that allows the precise updating of high-resolution thematic maps. For this protocol, images obtained through the Sentinel 2A satellite, with a return time of five days, have been merged with Light Detection and Ranging (LiDAR) data with a density of 0...
March 9, 2018: Sensors
Zachariah J Sperry, Kyounghwan Na, Saman S Parizi, Hillel J Chiel, John Seymour, Euisik Yoon, Tim M Bruns
The dorsal root ganglia (DRG) are promising nerve structures for sensory neural interfaces because they provide centralized access to primary afferent cell bodies and spinal reflex circuitry. In order to harness this potential, new electrode technologies are needed which take advantage of the unique properties of DRG, specifically the high density of neural cell bodies at the dorsal surface. Here we report initial <i>in vivo</i> results from the development of a flexible non-penetrating polyimide electrode array interfacing with the surface of ganglia...
March 9, 2018: Journal of Neural Engineering
Daniel F Alamidi, Amir Smailagic, Abdel W Bidar, Nicole S Parker, Marita Olsson, Paul D Hockings, Kerstin M Lagerstrand, Lars E Olsson
BACKGROUND: Lung T1 is a potential translational biomarker of lung disease. The precision and repeatability of variable flip angle (VFA) T1 mapping using modern 3D ultrashort echo time (UTE) imaging of the whole lung needs to be established before it can be used to assess response to disease and therapy. PURPOSE: To evaluate the feasibility of regional lung T1 quantification with VFA 3D-UTE and to investigate long- and short-term T1 repeatability in the lungs of naive mice...
March 8, 2018: Journal of Magnetic Resonance Imaging: JMRI
Manuel Lisardo Sánchez, Arturo Mangas, Luis Enrique Medina, Luis Angel Aguilar, Zaida Díaz-Cabiale, José Angel Narváez, Rafael Coveñas
INTRODUCTION: The distribution of the immunoreactive cell bodies and fibers containing neurotensin in the alpaca diencephalon was determined by an immunohistochemical technique. MATERIAL AND METHODS: The study was carried out in four male alpacas that lived at sea level. Brains of deeply anesthetized animals were fixed by perfusion with 4% paraformaldehyde. Cryostat sections were stained by a standard IHC method. RESULTS: Cell bodies containing neurotensin were observed in the zona incerta and hypothalamus...
March 8, 2018: Folia Histochemica et Cytobiologica
Laura Casas, Pablo Saenz-Agudelo, Xabier Irigoien
Clownfishes are an excellent model system for investigating the genetic mechanism governing hermaphroditism and socially-controlled sex change in their natural environment because they are broadly distributed and strongly site-attached. Genomic tools, such as genetic linkage maps, allow fine-mapping of loci involved in molecular pathways underlying these reproductive processes. In this study, a high-density genetic map of Amphiprion bicinctus was constructed with 3146 RAD markers in a full-sib family organized in 24 robust linkage groups which correspond to the haploid chromosome number of the species...
March 6, 2018: Scientific Reports
Adam Wang, Alexander Maslowski, Philippe Messmer, Mathias Lehmann, Adam Strzelecki, Elaine Yu, Pascal Paysan, Marcus Brehm, Peter Munro, Josh Star-Lack, Dieter Seghers
PURPOSE: To correct for scatter in kV cone-beam CT (CBCT) projection data on a clinical system using a new tool, Acuros® CTS, that estimates scatter images rapidly and accurately by deterministically solving the linear Boltzmann transport equation. METHODS: Phantom and patient CBCT scans were acquired on TrueBeam® radiotherapy machines. A first-pass reconstruction was used to create water and bone density maps of the imaged object, which was updated to include a more accurate representation of the patient couch...
March 6, 2018: Medical Physics
Shannon Coy, Rumana Rashid, Jia-Ren Lin, Ziming Du, Andrew M Donson, Todd C Hankinson, Nicholas K Foreman, Peter E Manley, Mark W Kieran, David A Reardon, Peter K Sorger, Sandro Santagata
Background: Craniopharyngiomas are neoplasms of the sellar/parasellar region that are classified into adamantinomatous (ACP) and papillary (PCP) subtypes. Surgical resection of craniopharyngiomas is challenging, and recurrence is common, frequently leading to profound morbidity. BRAF V600E mutations render PCP susceptible to BRAF/MEK inhibitors, but effective targeted therapies are needed for ACP. We explored the feasibility of targeting the PD-1/PD-L1 immune checkpoint pathway in ACP and PCP...
March 2, 2018: Neuro-oncology
Yasmina Talmat-Amar, Yoan Arribat, Marie-Laure Parmentier
Structural microtubule associated protein Tau is found in high amount in axons and is involved in several neurodegenerative diseases. Although many studies have highlighted the toxicity of an excess of Tau in neurons, the in vivo understanding of the endogenous role of Tau in axon morphology and physiology is poor. Indeed, knock-out mice display no strong cytoskeleton or axonal transport phenotype, probably because of some important functional redundancy with other microtubule-associated proteins (MAPs). Here, we took advantage of the model organism Drosophila , which genome contains only one homologue of the Tau/MAP2/MAP4 family to decipher (endogenous) Tau functions...
March 6, 2018: International Journal of Molecular Sciences
Maliheh Madanian, Ali Reza Soffianian, Saeid Soltani Koupai, Saeid Pourmanafi, Mehdi Momeni
Urban expansion can cause extensive changes in land use and land cover (LULC), leading to changes in temperature conditions. Land surface temperature (LST) is one of the key parameters that should be considered in the study of urban temperature conditions. The purpose of this study was, therefore, to investigate the effects of changes in LULC due to the expansion of the city of Isfahan on LST using landscape metrics. To this aim, two Landsat 5 and Landsat 8 images, which had been acquired, respectively, on August 2, 1985, and July 4, 2015, were used...
March 3, 2018: Environmental Monitoring and Assessment
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