keyword
MENU ▼
Read by QxMD icon Read
search

high-density mapping

keyword
https://www.readbyqxmd.com/read/27912315/genetics-of-infectious-and-inflammatory-diseases-overlapping-discoveries-from-association-and-exome-sequencing-studies
#1
David Langlais, Nassima Fodil, Philippe Gros
Genome technologies have defined a complex genetic architecture in major infectious, inflammatory, and autoimmune disorders. High density marker arrays and Immunochips have powered genome-wide association studies (GWAS) that have mapped nearly 450 genetic risk loci in 22 major inflammatory diseases, including a core of common genes that play a central role in pathological inflammation. Whole-exome and whole-genome sequencing have identified more than 265 genes in which mutations cause primary immunodeficiencies and rare forms of severe inflammatory bowel disease...
December 1, 2016: Annual Review of Immunology
https://www.readbyqxmd.com/read/27912134/uncertainties-in-mapping-forest-carbon-in-urban-ecosystems
#2
Gang Chen, Emre Ozelkan, Kunwar K Singh, Jun Zhou, Marilyn R Brown, Ross K Meentemeyer
Spatially explicit urban forest carbon estimation provides a baseline map for understanding the variation in forest vertical structure, informing sustainable forest management and urban planning. While high-resolution remote sensing has proven promising for carbon mapping in highly fragmented urban landscapes, data cost and availability are the major obstacle prohibiting accurate, consistent, and repeated measurement of forest carbon pools in cities. This study aims to evaluate the uncertainties of forest carbon estimation in response to the combined impacts of remote sensing data resolution and neighborhood spatial patterns in Charlotte, North Carolina...
November 29, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27910580/analysis-of-magnetically-immersed-electron-guns-with-non-adiabatic-fields
#3
Alexander Pikin, James G Alessi, Edward N Beebe, Deepak Raparia, John Ritter
Electron diode guns, which have strongly varying magnetic or electric fields in a cathode-anode gap, were investigated in order to generate laminar electron beams with high current density using magnetically immersed guns. By creating a strongly varying radial electric field in a cathode-anode gap of the electron gun, it was demonstrated that the optical properties of the gun can be significantly altered, which allows the generation of a laminar, high-current electron beam with relatively low magnetic field on the cathode...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910439/talbot-lau-x-ray-deflectometer-electron-density-diagnostic-for-laser-and-pulsed-power-high-energy-density-plasma-experiments-invited
#4
M P Valdivia, D Stutman, C Stoeckl, C Mileham, I A Begishev, W Theobald, J Bromage, S P Regan, S R Klein, G Muñoz-Cordovez, M Vescovi, V Valenzuela-Villaseca, F Veloso
Talbot-Lau X-ray deflectometry (TXD) has been developed as an electron density diagnostic for High Energy Density (HED) plasmas. The technique can deliver x-ray refraction, attenuation, elemental composition, and scatter information from a single Moiré image. An 8 keV Talbot-Lau interferometer was deployed using laser and x-pinch backlighters. Grating survival and electron density mapping were demonstrated for 25-29 J, 8-30 ps laser pulses using copper foil targets. Moiré pattern formation and grating survival were also observed using a copper x-pinch driven at 400 kA, ∼1 kA/ns...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27905974/dynamic-denominators-the-impact-of-seasonally-varying-population-numbers-on-disease-incidence-estimates
#5
Elisabeth Zu Erbach-Schoenberg, Victor A Alegana, Alessandro Sorichetta, Catherine Linard, Christoper Lourenço, Nick W Ruktanonchai, Bonita Graupe, Tomas J Bird, Carla Pezzulo, Amy Wesolowski, Andrew J Tatem
BACKGROUND: Reliable health metrics are crucial for accurately assessing disease burden and planning interventions. Many health indicators are measured through passive surveillance systems and are reliant on accurate estimates of denominators to transform case counts into incidence measures. These denominator estimates generally come from national censuses and use large area growth rates to estimate annual changes. Typically, they do not account for any seasonal fluctuations and thus assume a static denominator population...
October 12, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27903720/oscillatory-dynamics-underlying-perceptual-narrowing-of-native-phoneme-mapping-from-6-to-12-months-of-age
#6
Silvia Ortiz-Mantilla, Jarmo A Hämäläinen, Teresa Realpe-Bonilla, April A Benasich
: During the first months of life, human infants process phonemic elements from all languages similarly. However, by 12 months of age, as language-specific phonemic maps are established, infants respond preferentially to their native language. This process, known as perceptual narrowing, supports neural representation and thus efficient processing of the distinctive phonemes within the sound environment. Although oscillatory mechanisms underlying processing of native and non-native phonemic contrasts were recently delineated in 6-month-old infants, the maturational trajectory of these mechanisms remained unclear...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27903645/upgrading-short-read-animal-genome-assemblies-to-chromosome-level-using-comparative-genomics-and-a-universal-probe-set
#7
Joana Damas, Rebecca O'Connor, Marta Farré, Vasileios Panagiotis E Lenis, Henry J Martell, Anjali Mandawala, Katie Fowler, Sunitha Joseph, Martin T Swain, Darren K Griffin, Denis M Larkin
Most recent initiatives to sequence and assemble new species' genomes de-novo fail to achieve the ultimate endpoint to produce contigs, each representing one whole chromosome. Even the best-assembled genomes (using contemporary technologies) consist of sub-chromosomal sized scaffolds. To circumvent this problem, we developed a novel approach that combines computational algorithms to merge scaffolds into chromosomal fragments, PCR-based scaffold verification and physical mapping to chromosomes. Multi-genome-alignment-guided probe selection led to the development of a set of universal avian BAC clones that permit rapid anchoring of multiple scaffolds to chromosomes on all avian genomes...
November 30, 2016: Genome Research
https://www.readbyqxmd.com/read/27903438/neurite-density-imaging-versus-imaging-of-microscopic-anisotropy-in-diffusion-mri-a-model-comparison-using-spherical-tensor-encoding
#8
Björn Lampinen, Filip Szczepankiewicz, Johan Mårtensson, Danielle van Westen, Pia C Sundgren, Markus Nilsson
In diffusion MRI (dMRI), microscopic diffusion anisotropy can be obscured by orientation dispersion. Separation of these properties is of high importance, since it could allow dMRI to non-invasively probe elongated structures such as neurites (axons and dendrites). However, conventional dMRI, based on single diffusion encoding (SDE), entangles microscopic anisotropy and orientation dispersion with intra-voxel variance in isotropic diffusivity. SDE-based methods for estimating microscopic anisotropy, such as the neurite orientation dispersion and density imaging (NODDI) method, must thus rely on model assumptions to disentangle these features...
November 26, 2016: NeuroImage
https://www.readbyqxmd.com/read/27903066/the-spatio-temporal-distribution-of-oncomelania-hupensis-along-yangtze-river-in-jiangsu-province-china-after-implementation-of-a-new-integrated-schistosomiasis-control-strategy
#9
Jian He, Wei Li, Robert Bergquist, Jian-Feng Zhang, Liang Shi, Song Zhao, Feng Wu, Kun Yang
This study concerns an integrated strategy of schistosomiasis control, focusing on the management and elimination of the main transmission cycles and reservoirs along Yangtze river, Jiangsu Province (China), instituted in 2004. Our analysis, including mapping, spatial autocorrelation and spatio-temporal scanning, was implemented between 2001 and 2013 to explore the changes in the distribution of Oncomelania hupensis, the intermediate host of Schistosoma japonicum. Two high-density snail locations in the upper and middle reaches of the river were observed along with one high-risk area due to infected snails in the upper reaches at the beginning of the study period...
November 29, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27903061/geographic-distribution-of-canine-heartworm-dirofilaria-immitis-infection-in-stray-dogs-of-eastern-romania
#10
Lavinia Ciucă, Vincenzo Musella, Liviu D Miron, Maria Paola Maurelli, Giuseppe Cringoli, Antonio Bosco, Laura Rinaldi
A survey was conducted in the eastern part of Romania to assess the prevalence and geographical distribution of Dirofilaria immitis in dogs. Plasma samples were collected from 458 stray dogs hosted in shelters in 8 counties and tested serologically for the presence of heartworm. In addition, 45 blood samples from dogs of a shelter in Galati city were examined by the modified Knott and multiplex polymerase chain reaction (PCR) techniques. The immmunological assay showed a heartworm infection prevalence of 8...
November 21, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27903056/spatial-pattern-evolution-of-aedes-aegypti-breeding-sites-in-an-argentinean-city-without-a-dengue-vector-control-programme
#11
Manuel O Espinosa, Francisco Polop, Camilo H Rotela, Marcelo Abril, Carlos M Scavuzzo
The main objective of this study was to obtain and analyse the space-time dynamics of Aedes aegypti breeding sites in Clorinda City, Formosa Province, Argentina coupled with landscape analysis using the maximum entropy approach in order to generate a dengue vector niche model. In urban areas, without vector control activities, 12 entomologic (larval) samplings were performed during three years (October 2011 to October 2014). The entomologic surveillance area represented 16,511 houses. Predictive models for Aedes distribution were developed using vector breeding abundance data, density analysis, clustering and geoprocessing techniques coupled with Earth observation satellite data...
November 21, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27903052/assessing-spatial-inequalities-in-accessing-community-pharmacies-a-mixed-geographically-weighted-approach
#12
Alexander Domnich, Lucia Arata, Daniela Amicizia, Alessio Signori, Roberto Gasparini, Donatella Panatto
Geographical accessibility is an important determinant for the utilisation of community pharmacies. The present study explored patterns of spatial accessibility with respect to pharmacies in Liguria, Italy, a region with particular geographical and demographic features. Municipal density of pharmacies was proxied as the number of pharmacies per capita and per km2, and spatial autocorrelation analysis was performed to identify spatial clusters. Both non-spatial and spatial models were constructed to predict the study outcome...
November 16, 2016: Geospatial Health
https://www.readbyqxmd.com/read/27902806/orthology-guided-transcriptome-assembly-of-italian-ryegrass-and-meadow-fescue-for-single-nucleotide-polymorphism-discovery
#13
Štěpán Stočes, Tom Ruttink, Jan Bartoš, Bruno Studer, Steven Yates, Zbigniew Zwierzykowski, Michael Abrouk, Isabel Roldán-Ruiz, Tomasz Książczyk, Elodie Rey, Jaroslav Doležel, David Kopecký
Single-nucleotide polymorphisms (SNPs) represent natural DNA sequence variation. They can be used for various applications including the construction of high-density genetic maps, analysis of genetic variability, genome-wide association studies, and map-based cloning. Here we report on transcriptome sequencing in the two forage grasses, meadow fescue ( Huds.) and Italian ryegrass ( Lam.), and identification of various classes of SNPs. Using the Orthology Guided Assembly (OGA) strategy, we assembled and annotated a total of 18,952 and 19,036 transcripts for Italian ryegrass and meadow fescue, respectively...
November 2016: Plant Genome
https://www.readbyqxmd.com/read/27899666/structures-of-human-srp72-complexes-provide-insights-into-srp-rna-remodeling-and-ribosome-interaction
#14
Matthias M M Becker, Karine Lapouge, Bernd Segnitz, Klemens Wild, Irmgard Sinning
Co-translational protein targeting and membrane protein insertion is a fundamental process and depends on the signal recognition particle (SRP). In mammals, SRP is composed of the SRP RNA crucial for SRP assembly and function and six proteins. The two largest proteins SRP68 and SRP72 form a heterodimer and bind to a regulatory site of the SRP RNA. Despite their essential roles in the SRP pathway, structural information has been available only for the SRP68 RNA-binding domain (RBD). Here we present the crystal structures of the SRP68 protein-binding domain (PBD) in complex with SRP72-PBD and of the SRP72-RBD bound to the SRP S domain (SRP RNA, SRP19 and SRP68) detailing all interactions of SRP72 within SRP...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27898866/genomic-analyses-of-tropical-beef-cattle-fertility-based-on-genotyping-pools-of-brahman-cows-with-unknown-pedigree
#15
A Reverter, L R Porto-Neto, M R S Fortes, R McCulloch, R E Lyons, S Moore, D Nicol, J Henshall, S A Lehnert
We introduce an innovative approach to lowering the overall cost of obtaining genomic EBV (GEBV) and encourage their use in commercial extensive herds of Brahman beef cattle. In our approach, the DNA genotyping of cow herds from 2 independent properties was performed using a high-density bovine SNP chip on DNA from pooled blood samples, grouped according to the result of a pregnancy test following their first and second joining opportunities. For the DNA pooling strategy, 15 to 28 blood samples from the same phenotype and contemporary group were allocated to pools...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898821/development-of-a-high-density-linkage-map-and-tagging-leaf-spot-resistance-in-pearl-millet-using-genotyping-by-sequencing-markers
#16
Somashekhar M Punnuri, Jason G Wallace, Joseph E Knoll, Katie E Hyma, Sharon E Mitchell, Edward S Buckler, Rajeev K Varshney, Bharat P Singh
Pearl millet [ (L.) R. Br; also (L.) Morrone] is an important crop throughout the world but better genomic resources for this species are needed to facilitate crop improvement. Genome mapping studies are a prerequisite for tagging agronomically important traits. Genotyping-by-sequencing (GBS) markers can be used to build high-density linkage maps, even in species lacking a reference genome. A recombinant inbred line (RIL) mapping population was developed from a cross between the lines 'Tift 99DB' and 'Tift 454'...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27898818/a-consensus-map-in-cultivated-hexaploid-oat-reveals-conserved-grass-synteny-with-substantial-subgenome-rearrangement
#17
Ashley S Chaffin, Yung-Fen Huang, Scott Smith, Wubishet A Bekele, Ebrahiem Babiker, Belaghihalli N Gnanesh, Bradley J Foresman, Steven G Blanchard, Jeremy J Jay, Robert W Reid, Charlene P Wight, Shiaoman Chao, Rebekah Oliver, Emir Islamovic, Frederic L Kolb, Curt McCartney, Jennifer W Mitchell Fetch, Aaron D Beattie, Åsmund Bjørnstad, J Michael Bonman, Tim Langdon, Catherine J Howarth, Cory R Brouwer, Eric N Jellen, Kathy Esvelt Klos, Jesse A Poland, Tzung-Fu Hsieh, Ryan Brown, Eric Jackson, Jessica A Schlueter, Nicholas A Tinker
Hexaploid oat ( L., 2 = 6 = 42) is a member of the Poaceae family and has a large genome (∼12.5 Gb) containing 21 chromosome pairs from three ancestral genomes. Physical rearrangements among parental genomes have hindered the development of linkage maps in this species. The objective of this work was to develop a single high-density consensus linkage map that is representative of the majority of commonly grown oat varieties. Data from a cDNA-derived single-nucleotide polymorphism (SNP) array and genotyping-by-sequencing (GBS) were collected from the progeny of 12 biparental recombinant inbred line populations derived from 19 parents representing oat germplasm cultivated primarily in North America...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27898812/a-high-density-linkage-map-of-the-ancestral-diploid-strawberry-constructed-with-single-nucleotide-polymorphism-markers-from-the-istraw90-array-and-genotyping-by-sequencing
#18
Lise L Mahoney, Daniel J Sargent, F Abebe-Akele, Dave J Wood, Judson A Ward, Nahla V Bassil, James F Hancock, Kevin M Folta, Thomas M Davis
Makino is recognized as an ancestor of the octoploid strawberry species, which includes the cultivated strawberry, × Duchesne ex Rozier. Here we report the construction of the first high-density linkage map for . The linkage map (Fii map) is based on two high-throughput techniques of single nucleotide polymorphism (SNP) genotyping: the IStraw90 Array (hereafter "Array"), and genotyping by sequencing (GBS). The F generation mapping population was derived by selfing hybrid F1D, the product of a cross between two divergent accessions collected from Hokkaido, Japan...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27898771/dissection-of-genetic-factors-underlying-wheat-kernel-shape-and-size-in-an-elite-%C3%A3-nonadapted-cross-using-a-high-density-snp-linkage-map
#19
Ajay Kumar, E E Mantovani, R Seetan, A Soltani, M Echeverry-Solarte, S Jain, S Simsek, D Doehlert, M S Alamri, E M Elias, S F Kianian, M Mergoum
Wheat kernel shape and size has been under selection since early domestication. Kernel morphology is a major consideration in wheat breeding, as it impacts grain yield and quality. A population of 160 recombinant inbred lines (RIL), developed using an elite (ND 705) and a nonadapted genotype (PI 414566), was extensively phenotyped in replicated field trials and genotyped using Infinium iSelect 90K assay to gain insight into the genetic architecture of kernel shape and size. A high density genetic map consisting of 10,172 single nucleotide polymorphism (SNP) markers, with an average marker density of 0...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27898049/mecs-vine-%C3%A2-a-new-proximal-sensor-for-segmented-mapping-of-vigor-and-yield-parameters-on-vineyard-rows
#20
Matteo Gatti, Paolo Dosso, Marco Maurino, Maria Clara Merli, Fabio Bernizzoni, Facundo José Pirez, Bonfiglio Platè, Gian Carlo Bertuzzi, Stefano Poni
Ground-based proximal sensing of vineyard features is gaining interest due to its ability to serve in even quite small plots with the advantage of being conducted concurrently with normal vineyard practices (i.e., spraying, pruning or soil tilling) with no dependence upon weather conditions, external services or law-imposed limitations. The purpose of the present work was to test performance of the new terrestrial multi-sensor MECS-VINE(®) in terms of reliability and degree of correlation with several canopy growth and yield parameters in the grapevine...
November 27, 2016: Sensors
keyword
keyword
112411
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"