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https://www.readbyqxmd.com/read/24948059/synergistic-effect-of-the-combination-of-gallic-acid-and-famotidine-in-protection-of-rat-gastric-mucosa
#1
K Asokkumar, Saikat Sen, M Umamaheswari, A T Sivashanmugam, V Subhadradevi
BACKGROUND: Antioxidant supplements with existing drugs may confer better therapeutic efficacy in oxidative stress related diseases. The purpose of the present work was to characterize the interaction and investigate the protective effect of H2 blocker famotidine and gallic acid in combination against experimentally induced peptic ulcer. METHODS: Preventive effect of gallic acid and famotidine in different combinations was investigated against aspirin plus pyloric ligation induced ulcer in rat...
August 2014: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/23554563/protective-role-of-ceftriaxone-plus-sulbactam-with-vrp1034-on-oxidative-stress-hematological-and-enzymatic-parameters-in-cadmium-toxicity-induced-rat-model
#2
Vivek Kumar Dwivedi, Anuj Bhatanagar, Manu Chaudhary
We investigated the protective role of ceftriaxone plus sulbactam with VRP1034 (Elores) on hematological, lipid peroxidation, antioxidant enzymatic activities and Cd levels in the blood and tissues of cadmium exposed rats. Twenty-four male rats were divided into three groups of eight rats each. The control group received distilled water whereas group II received CdCl2 (1.5 mg/4 ml/body weight) through gastric gavage for 21 days. Group III received CdCl2 and was treated with ceftriaxone plus sulbactam with VRP1034 for 21 days...
December 2012: Interdisciplinary Toxicology
https://www.readbyqxmd.com/read/23042592/effect-of-coriander-on-thioacetamide-induced-hepatotoxicity-in-rats
#3
Abdel Halim A Moustafa, Ehab Mostafa M Ali, Said S Moselhey, Ehab Tousson, Karim S El-Said
Thioacetamide (TAA) is a potent hepatotoxin that causes centrilobulal necrosis and nephrotoxic damage following acute administration. Prolonged exposure to TAA can result in bile duct proliferation and liver cirrhosis histologically similar to that caused due to viral hepatitis infection. Coriander in food increases the antioxidant content, acting as a natural antioxidant and inhibiting undesirable oxidation processes. The present study investigated the antioxidant activity of Coriandrum sativum on TAA-induced hepatotoxicity in the male rats...
August 2014: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/22329239/protective-effect-of-ellagic-acid-and-pumpkin-seed-oil-against-methotrexate-induced-small-intestine-damage-in-rats
#4
Noha A El-Boghdady
Gastrointestinal toxicity is one of the most serious side effects in the methotrexate (MTX) treatment. This study was designed to investigate whether ellagic acid (EA) and/or pumpkin seed oil (PSO) had a protective effect on MTX-induced small intestine damage. Forty albino rats were randomized into five groups of 8 rats each. Group I served as a normal control group. In Group II, MTX was administered as a single dose (20 mg/kg) intraperitoneally. Groups III, IV and V were pre-treated respectively with either PSO (40 mg/kg), EA (10 mg/kg) or 0...
December 2011: Indian Journal of Biochemistry & Biophysics
https://www.readbyqxmd.com/read/21993003/oxytocin-inhibits-nadph-oxidase-and-p38-mapk-in-cisplatin-induced-nephrotoxicity
#5
COMPARATIVE STUDY
Laila A Rashed, Reem M Hashem, Hala M Soliman
Oxidative stress significantly contributes to cisplatin (CP)-associated cytotoxicity, and use of antioxidants could counteract such cytotoxic effects of CP. The major biochemical pathway for reactive oxygen species (ROS) formation proceeds through O₂⁻ production, which is generated by NADPH oxidase, such oxidative stress can activate p38 MAPK to intensify the cytotoxic effect of CP. We mainly aimed to study the protective effect of oxytocin (OT) on CP-induced nephrotoxicity whereas; it was previously shown to have anti-inflammatory effects in different inflammation models...
October 2011: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/21867456/hepatoprotective-constituents-of-torilis-radiata-moench-apiaceae
#6
Shahira M Ezzat, Hossam M Abdallah, Ghada A Fawzy, Shohda A El-Maraghy
An investigation of the aqueous ethanolic extract (AE) of the aerial parts of Torilis radiata Moench yielded two triterpenes (lupeol acetate (1) and α-amyrin (2)), a sterol (spinasterol (3)) from its n-hexane fraction (HF), a flavone (acacetin (4)), a coumarin (scopoletin (5)), a phenolic acid (ferulic acid (6)) from the chloroform fraction (CF) and a flavone glycoside (luteolin-7-O-glucoside (7)) from the n-butanol fraction (BF). The hepatoprotection of the AE and its fractions was assessed in terms of the reduction in histological damage, accompanied by restoration of the liver enzymes (alanine amino transferase (ALT), aspartate amino transferase (AST), lactate dehydrogenase (LDH)), a reduction in the inflammatory markers (tumour necrosis-α (TNF-α), nitric oxide (NO), N-acetyl-β-D-glucosaminidase (NAG) and myloperoxidase (MPO) in serum) and restoration of the oxidant balance by decreasing the serum and hepatic malondialdehyde (MDA) levels, along with increasing the activity of hepatic catalase (CAT), glutathione peroxidase (GSHPx) and the non-enzymatic antioxidant glutathione (GSH)...
2012: Natural Product Research
https://www.readbyqxmd.com/read/21705330/pulmonary-biocompatibility-assessment-of-inhaled-single-wall-and-multiwall-carbon-nanotubes-in-balb-c-mice
#7
COMPARATIVE STUDY
Prabakaran Ravichandran, Sudhakar Baluchamy, Ramya Gopikrishnan, Santhoshkumar Biradar, Vani Ramesh, Virupaxi Goornavar, Renard Thomas, Bobby L Wilson, Robert Jeffers, Joseph C Hall, Govindarajan T Ramesh
With the widespread application of carbon nanotubes (CNTs) in diverse commercial processes, scientists are now concerned about the potential health risk of occupational exposures. In this study, CNT-induced pulmonary toxicity was investigated by exposing BALB/c mice to aerosolized single-wall (SW) CNT and multiwall (MW) CNT (5 μg/g of mice) for 7 consecutive days in a nose-only exposure system. Microscopic studies showed that inhaled CNTs were homogeneously distributed in the mouse lung. The total number of bronchoalveolar lavage polymorphonuclear leukocytes recovered from the mice exposed to SWCNT and MWCNT (1...
August 26, 2011: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/21647614/attenuation-of-oxidative-stress-inflammation-and-early-markers-of-tumor-promotion-by-caffeic-acid-in-fe-nta-exposed-kidneys-of-wistar-rats
#8
Muneeb U Rehman, Sarwat Sultana
Iron nitrilotriacetate (Fe-NTA), a chief environmental pollutant, is known for its extensive toxic manifestations on renal system. In the present study, caffeic acid, one of the most frequently occurring phenolic acids in fruits, grains, and dietary supplements was evaluated for its shielding effect against the Fe-NTA-induced oxidative, inflammatory, and pathological damage in kidney. Fe-NTA was administered (9 mg Fe/kg body weight) intraperitoneally to the Wistar male rats on 20th day while caffeic acid was administered orally (20 and 40 mg/kg body weight) before administration of Fe-NTA...
November 2011: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/20037732/attenuation-of-acute-lung-inflammation-and-injury-by-whole-body-cooling-in-a-rat-heatstroke-model
#9
Hsi-Hsing Yang, Ching-Ping Chang, Ruei-Tang Cheng, Mao-Tsun Lin
Whole body cooling is the current therapy of choice for heatstroke because the therapeutic agents are not available. In this study, we assessed the effects of whole body cooling on several indices of acute lung inflammation and injury which might occur during heatstroke. Anesthetized rats were randomized into the following groups and given (a) no treatment or (b) whole body cooling immediately after onset of heatstroke. As compared with the normothermic controls, the untreated heatstroke rats had higher levels of pleural exudates volume and polymorphonuclear cell numbers, lung myloperoxidase activity and inducible nitric oxide synthase expression, histologic lung injury score, and bronchoalveolar proinflammatory cytokines and glutamate, and PaCO2...
2009: Journal of Biomedicine & Biotechnology
https://www.readbyqxmd.com/read/17977702/bioavailability-of-apocynin-through-its-conversion-to-glycoconjugate-but-not-to-diapocynin
#10
Qun Wang, Robert E Smith, Ron Luchtefeld, Albert Y Sun, Agnes Simonyi, Rensheng Luo, Grace Y Sun
Apocynin (4-hydroxy-3-methoxyacetophenone) is a major active ingredient from the rhizomes of Picrorhiza kurroa, a botanical plant used as an herbal medicine for treatment of a number of inflammatory diseases. Recently, apocynin is regarded as a specific inhibitor for NADPH oxidase in cell and animal models. In vitro studies indicated conversion of apocynin to diapocynin in the presence of peroxidases, e.g., myloperoxidase, posing the possibility that diapocynin also contributes to the anti-oxidative action of apocynin...
June 2008: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/15836859/inhibition-of-nfkappab-activation-with-curcumin-attenuates-plasma-inflammatory-cytokines-surge-and-cardiomyocytic-apoptosis-following-cardiac-ischemia-reperfusion
#11
Chi-Hsiao Yeh, Tzu-Ping Chen, Yi-Cheng Wu, Yu-Min Lin, Pyng Jing Lin
BACKGROUND: Following cardiopulmonary bypass (CPB) and cardiac global ischemia and reperfusion, pro-inflammatory cytokines are activated and cause cardiomyocytic injury. Nuclear factor (NF)-kappaB is involved in regulating inflammatory signal transduction. Curcumin inhibits NF-kappaB activation and blocks the inflammatory responses. We studied whether curcumin could decrease myocardial ischemia/reperfusion injury with cardioplegia during CPB and attenuate the appearance of apoptosis of cardiomyocytes...
May 1, 2005: Journal of Surgical Research
https://www.readbyqxmd.com/read/15550554/ameliorating-effect-of-hepatocyte-growth-factor-on-inflammatory-bowel-disease-in-a-murine-model
#12
Koushi Oh, Yuji Iimuro, Masaharu Takeuchi, Yasufumi Kaneda, Tsuyoshi Iwasaki, Nobuyuki Terada, Takayuki Matsumoto, Kenji Nakanishi, Jiro Fujimoto
Hepatocyte growth factor (HGF), a multifunctional cytokine, accelerates intestinal epithelial proliferation. We studied the effects of HGF in mice with trinitrobenzene sulfonic acid-induced colitis, which shows clinical and molecular resemblance to Crohn's disease. Mice with colitis repeatedly were transfected intramuscularly with human HGF cDNA. Weight, survival, histopathology, proinflammatory cytokine mRNAs, and leukocyte infiltration were assessed. Treatment with HGF cDNA induced tyrosine phosphorylation of intestinal c-Met/HGF receptors, inhibited apoptosis, and promoted mitosis in intestinal epithelial cells, accelerating intestinal epithelial restoration and suppressing inflammation...
April 2005: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/15168810/the-effect-of-recombinant-human-growth-hormone-rhgh-on-trinitrobenzene-sulfonic-acid-induced-colitis-in-rats-an-experimental-study
#13
COMPARATIVE STUDY
Eray Kara, Hulya Sungurtekin, Ugur Sungurtekin, Murat Alkanat, Ozer Ilkgul
The limited efficacy of standard medical therapies for inflammatory bowel diseases has resulted in a continuing search for alternative treatments. Growth hormone (GH) has shown to have mutagenic and proliferative effects on intestinal cells. This study was designed to identify the effect of growth hormone on trinitrobenzene slfonic acid-induced colitis (TNBSIC) in rats. This study was carried out on 30 rats, divided in 3 groups: group 1: TNBSIC+ GH, group 2: TNBSIC, group 3: saline enema. Colitis was induced in male Sprague-Dawley rats (200 g-250 g) by intracolonic installation of 2, 4, 6-trinitrobenzene sulphonic acid in 50% ethanol...
March 2004: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/14536000/helicobacter-induced-gastritis-in-mice-not-expressing-metallothionein-i-and-ii
#14
Cuong D Tran, Hien Huynh, Maartje van den Berg, Mechtelt van der Pas, M A Fiona Campbell, Jeffrey C Philcox, Peter Coyle, Allau M Rofe, Ross N Butler
BACKGROUND: Helicobacter pylori a primary cause of gastritis and peptic ulcer disease, is associated with increased production of reactive oxygen species within the gastric mucosa. Metallothionein (MT), a low-molecular-weight, cysteine-rich, metal-binding ligand, has been shown to sequester reactive oxygen species and reduce tissue damage. This study investigates the role of MT in H. pylori-induced gastritis in mice. MATERIALS AND METHODS: Control (MT+/+) and MT-null (MT-/-) mice were inoculated with either 1 x 108H...
2003: Helicobacter
https://www.readbyqxmd.com/read/12643851/inhibition-of-matrix-metalloproteinases-reduces-local-and-distant-organ-injury-following-experimental-acute-pancreatitis
#15
Bart E Muhs, Sundeep Patel, Herman Yee, Stuart Marcus, Peter Shamamian
BACKGROUND: Pulmonary complications from pancreatitis involve parenchymal destruction via proteolytic enzymes. Matrix metalloproteinases (MMPs) may play an important role in pulmonary injury following acute severe pancreatitis. We hypothesized that local and distant organ injury would be decreased by the presence of an MMP inhibitor (Batimistat; BB-94) following severe acute pancreatitis (AP). METHODS: Eighteen male rats were randomized into two groups: BB-94 (AP + 40 mg/kg/24 h BB-94 ip x three doses) or control (AP + 20 ml/kg/24 h normal saline ip x three doses)...
February 2003: Journal of Surgical Research
https://www.readbyqxmd.com/read/10381813/efficacy-of-keratinocyte-growth-factor-2-in-dextran-sulfate-sodium-induced-murine-colitis
#16
R Miceli, M Hubert, G Santiago, D L Yao, T A Coleman, K A Huddleston, K Connolly
The purpose of this study was to determine the efficacy of a novel human protein, keratinocyte growth factor-2 (KGF-2), in a model of murine colitis induced by ad libitum exposure to a 4% solution of dextran sulfate sodium (DSS) in the drinking water. Initial evaluation of KGF-2 was based on its ability to reduce weight loss, stool score, and histological score in mice exposed to DSS for 7 days. When KGF-2 (0.1-10.0 mg/kg i.p. or s.c.) was injected daily into DSS-treated mice from day 0 to 7, it significantly reduced all three parameters in a dose-response fashion, with a minimum effective dose of between 1 and 3 mg/kg...
July 1999: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/8914759/hydrogen-peroxide-generation-by-polymorphonuclear-leukocytes-exposed-to-peritoneal-dialysis-effluent
#17
I Daniels, K S Bhatia, C J Porter, M A Lindsay, A G Morgan, R P Burden, J Fletcher
In the presence of peritoneal dialysis effluent (PDE), human polymorphonuclear leukocytes (PMN) showed reduced production of hydrogen peroxide and hypochlorous acid (H2O2 and HOCl, respectively) when at rest and when stimulated with both soluble (formylmethionyl-leucyl-phenylalanine and phorbol myristate acetate) and particulate (Staphylococcus epidermidis) agonists. This effect occurred in a concentration-dependent manner between 0 and 70%. (vol/vol) dialysis effluent. The inhibition of H2O2 and HOCl observed in resting, formy-methionylleucyphenyalanine-stimulated, and S...
November 1996: Clinical and Diagnostic Laboratory Immunology
https://www.readbyqxmd.com/read/8879188/contrasting-response-of-lung-parenchymal-cells-to-instilled-tnf-alpha-and-ifn-gamma-the-inducibility-of-specific-cell-icam-1-in-vivo
#18
B H Kang, B D Manderschied, Y C Huang, J D Crapo, L Y Chang
Induction of intercellular adhesion molecule-1 (ICAM-1) by proinflammatory cytokines during inflammation plays an important role in regulating polymorphonuclear neutrophil (PMN) migration and localization. In this report, we examined the effects of tumor necrosis factor-alpha (TNF alpha) and interferon-gamma (IFN gamma) on specific lung cell expression of ICAM-1 in vivo and the accompanying morphological changes. Balb-c mice were treated with phosphate-buffered saline (PBS) alone or with PBS containing 5 micrograms TNF alpha or IFN gamma through intranasal instillation...
October 1996: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/8545618/effects-of-plain-and-controlled-ileal-release-budesonide-formulations-in-experimental-ileitis
#19
A J Boyd, I A Sherman, F G Saibil
BACKGROUND: Budesonide combines a topical anti-inflammatory activity with high first-pass hepatic extraction. This study compared the effects of plain and controlled-ileal-release (CIR) formulations of budesonide on intestinal inflammation. METHODS: Ileitis was induced in hamsters by an intraluminal injection of trinitrobenzene sulphonic acid. Inflammation was assessed histologically and by measuring mastocytosis and myloperoxidase activity. Adrenal-pituitary axis suppression was assessed by radio-immunoassay of plasma cortisol...
October 1995: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/2363707/partial-purification-and-characterization-of-a-peroxidase-activity-from-human-placenta
#20
J L Nelson, A P Kulkarni
Peroxidases can metabolize a variety of xenobiotics to reactive intermediates capable of binding to protein or DNA. The potential role of these enzymes in fetotoxicity has not been explored. In this study, the presence of peroxidase activity was observed in human term and pre-term placenta. Human term placental peroxidase activity (HTPP) was partially purified by concanavalin A affinity chromatography from CaCl2 extracts of the particulate fraction. HTPP appears to be a membrane-bound glycoprotein. Arachidonic acid-dependent oxidation of guaiacol was not observed, suggesting that the peroxidase activity was not due to prostaglandin synthase...
June 15, 1990: Biochemical Journal
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