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JOURNAL ARTICLE
Anant Mohan, Karan Madan, Vijay Hadda, Saurabh Mittal, Tejas Suri, Irfan Shekh, Randeep Guleria, Abdul Khader, Prashant Chhajed, Devasahayam J Christopher, Rajesh Swarnakar, Ritesh Agarwal, Ashutosh Nath Aggarwal, Shubham Aggarwal, Gyanendra Agrawal, Irfan Ismail Ayub, Muniza Bai, Bhvya Baldwa, Abhishek Chauhan, Rakesh Chawla, Manu Chopra, Dhruva Choudhry, Raja Dhar, Sahajal Dhooria, Rakesh Garg, Ayush Goel, Manoj Goel, Rajiv Goyal, Nishkarsh Gupta, B G Manjunath, Hariharan Iyer, Deepali Jain, Ajmal Khan, Raj Kumar, Parvaiz A Koul, Ajay Lall, M Arunachalam, Neha K Madan, Ravindra Mehta, N Loganathan, Alok Nath, Vivek Nangia, Amita Nene, Dharmesh Patel, V R Pattabhiraman, Arun Raja, Benin Rajesh, Amith Rangarajan, Vidushi Rathi, Inderpaul Singh Sehgal, Sujay H Shankar, Girish Sindhwani, Pawan K Singh, Arjun Srinivasan, Deepak Talwar, Balamugesh Thangakunam, Pawan Tiwari, Rahul Tyagi, V Naren Chandra, V Sharada, Rohit Vadala, Kavitha Venkatnarayan
Over the past decade, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become an indispensable tool in the diagnostic armamentarium of the pulmonologist. As the expertise with EBUS-TBNA has evolved and several innovations have occurred, the indications for its use have expanded. However, several aspects of EBUS-TBNA are still not standardized. Hence, evidence-based guidelines are needed to optimize the diagnostic yield and safety of EBUS-TBNA. For this purpose, a working group of experts from India was constituted...
2023: Lung India: Official Organ of Indian Chest Society
#22
JOURNAL ARTICLE
Tanima Chatterjee, Itika Arora, Lilly Underwood, Anastasiia Gryshyna, Terry L Lewis, Juan Xavier Masjoan Juncos, Burel R Goodin, Sonya Heath, Saurabh Aggarwal
An overwhelming number of people with HIV (PWH) experience chronic widespread pain (CWP) throughout their lifetimes. Previously, we demonstrated that PWH with CWP have increased hemolysis and attenuated heme oxygenase 1 (HO-1) levels. HO-1 degrades reactive, cell-free heme into antioxidants like biliverdin and carbon monoxide (CO). We found that high heme or low HO-1 caused hyperalgesia in animals, likely through multiple mechanisms. In this study, we hypothesized that high heme or low HO-1 caused mast cell activation/degranulation, resulting in the release of pain mediators like histamine and bradykinin...
June 3, 2023: Antioxidants (Basel, Switzerland)
#23
JOURNAL ARTICLE
Tanima Chatterjee, Itika Arora, Lilly B Underwood, Terry L Lewis, Juan Xavier Masjoan Juncos, Sonya L Heath, Burel R Goodin, Saurabh Aggarwal
Chronic widespread pain (CWP) is associated with a high rate of disability and decreased quality of life in people with HIV-1 (PWH). We previously showed that PWH with CWP have increased hemolysis and elevated plasma levels of cell-free heme, which correlate with low endogenous opioid levels in leukocytes. Further, we demonstrated that cell-free heme impairs β-endorphin synthesis/release from leukocytes. However, the cellular mechanisms by which heme dampens β-endorphin production are inconclusive...
June 6, 2023: Cells
#24
JOURNAL ARTICLE
A Stephen, Saritha Nair, Aparna Joshi, Sumit Aggarwal, Tulsi Adhikari, Vishal Diwan, Kangjam Rekha Devi, Bijaya Kumar Mishra, Girijesh Kumar Yadav, Damodar Sahu, Bal Kishan Gulati, Saurabh Sharma, Jeetendra Yadav, Senthanro Ovung, Chetna Duggal, Moina Sharma, Sampada Dipak Bangar, Pricilla B Rebecca, S Rani, Pradeep Selvaraj, Gladston G Xavier, Vanessa Peter, Basilea Watson, T Kannan, K S M D Asmathulla, Debdutta Bhattacharya, Jyotirmayee Turuk, Subrata Kumar Palo, Srikanta Kanungo, Ajit Kumar Behera, Ashok Kumar Pandey, Kamran Zaman, BrijRanjan Misra, Niraj Kumar, SthitaPragnya Behera, Rajeev Singh, Kanwar Narain, Rajni Kant, Seema Sahay, RajnarayanRamshankar Tiwari, Beena Elizabeth Thomas, N Karikalan, Samiran Panda, M Vishnu Vardhana Rao, Dhammsagar Ujagare, Sneha Chinchore
INTRODUCTION: Individual and community characteristics predictive of knowledge, perception, and attitude on COVID-19, specifically on gender, have not been adequately explored. OBJECTIVE: To examine the gender differences in COVID-19 knowledge, self-risk perception and public stigma among the general community and to understand other socio-demographic factors which were predictive of them. METHOD: A nationally representative cross-sectional multi-centric survey was conducted among adult individuals(≥18 yrs) from the community member (N = 1978) from six states and one union territory of India between August 2020 to February 2021...
July 2023: International Journal of Disaster Risk Reduction: IJDRR
#25
Ashish Gupta, Saurabh Puri, Neeru P Aggarwal, Gulshan Randhawa, Prem Mohan Jha
Typhoid fever is a potentially life-threatening infectious disease that presents itself with a wide array of symptoms ranging from uncomplicated fever to sepsis with multiorgan dysfunction syndrome. An 18-year-old male college student presented with progressively increasing fever with abdominal discomfort, anorexia, and persistent vomiting. Typhoid fever was suspected in view of clinical findings along with leukopenia, grossly elevated transaminases, and acute kidney injury. He was managed with intravenous (IV) antibiotics, which resulted in the resolution of fever and other symptoms...
2023: Indian Journal of Nephrology
#26
Ashish Gupta, Saurabh Puri, Neeru P Aggarwal, Gulshan S Randhwa, Prem Mohan Jha
Copper sulfate occurs as large blue crystals in nature, commonly known as "blue vitriol" or "blue stone." It is a potentially lethal poison with significant mortality. Copper sulfate is a powerful oxidizing agent and causes corrosive injury to the mucous membrane. The clinical course involves intravascular hemolysis resulting in anemia, jaundice, and renal failure. Laboratory diagnosis of the condition is not an issue; the difficulty is suspecting it, promptly initiating chelation therapy, and other supportive symptomatic treatment...
2023: Indian Journal of Nephrology
#27
JOURNAL ARTICLE
Saurabh Gupta, Amit Srivastava, Raskesh Malhotra, Manish Chadha, Aditya N Aggarwal
BACKGROUND: Negative-pressure wound therapy (NPWT) is an alternative method of wound management for spontaneous healing. However, availability and high cost of a conventional NPWT system remain a challenge. Bates Jensen wound assessment tool (BWAT) has been used to assess wound healing in diverse wound treatments. Although there have been studies evaluating change in BWAT score following application of commercially available NPWT device, there is no literature evaluating change in BWAT score following use of wall-mounted low-cost NPWT device...
June 2023: Indian Journal of Orthopaedics
#28
JOURNAL ARTICLE
Saurabh Varshney, Sumeet Angral, Pradeep Aggarwal, Suresh Sharma, Narendra Kumar, K S B S Sasanka, Prem Aanand
Mobile phones are being used by around 70% of the global population. A simple non-invasive procedure to detect early impairment of the acoustic nerve and auditory pathway is by auditory brainstem response (ABR). It's a response to the sound stimulus generated from the brainstem in the form of electrical impulses. To determine the effect of long-term usage of mobile phones on auditory brainstem responses (ABRs). This Epidemiological, cross-sectional study was undertaken at a tertiary care hospital and includes 865 individuals aged between 18 to 45 years using mobile phone for > 2 years...
April 2023: Indian Journal of Otolaryngology and Head and Neck Surgery
#29
Nitish Bansal, Saurabh Aggarwal, Punit Tiwari, Harmeet Kaur
INTRODUCTION: Actual coracoclavicular (CC) joint is a rare finding and usually incidental. It is mostly asymptomatic, but few cases have been reported in which there was associated shoulder pain and even brachial plexus neuralgia. It is not to be confused with CC ligament which is a well-known anatomical entity. CASE REPORT: Here, we present a case of symptomatic CC joint treated at our hospital. A 50-year-old man presented to the outdoor patient department of our hospital with a history of acute on chronic pain in the left shoulder...
October 2022: Journal of Orthopaedic Case Reports
#30
JOURNAL ARTICLE
Sunila Jain, Saurabh Garg, Nitin Aggarwal
Lipomas of the oral cavity are uncommon. Here we report a case of 85 year old female presenting with a progressively increasing large growth in the oropharynx which was diagnosed as lipoma on histopathology. The clinicoradiological and histopathological findings are discussed. To the best of our knowledge; this is one of the largest intraoral lipoma reported in India till date. The present case highlights the need to be aware of intraoral lipomas which can present as large growths at this unusual site so as to avoid any unwarranted aggressive surgery...
December 2022: Indian Journal of Otolaryngology and Head and Neck Surgery
#31
JOURNAL ARTICLE
Saurabh Sharma, Sumit Aggarwal, Ragini Kulkarni, Dinesh Kumar, Bijaya Kumar Mishra, Gaurav Raj Dwivedi, K Rekha Devi, Raja Sriswan Mamidi, Khangembam Jitenkumar Singh, Lucky Singh, Damodar Sahu, Tulsi Adhikari, Saritha Nair, Anil Kumar, Atul Juneja, Anshita Sharma, Shahina Begum, Suchitra Surve, Ranjan Kumar Prusty, Surendra Kumar, J J Babu Geddam, Gargi Meur, Mahesh Kumar Mummadi, Uma Kailash, Subrata Kumar Palo, Srikanta Kanungo, Jaya Singh Kshatri, Ajit Kumar Behera, Swagatika Swain, Rajeev Singh, Kamran Zaman, Hirawati Deval, Ashok Kumar Pandey, Abu Sarkar, Rajni Kant, Kanwar Narain, Luigi D'Aquino, Asheber Gaym, Vivek Virendra Singh, M Vishnu Vardhana Rao
BACKGROUND/OBJECTIVES: Globally, the COVID-19 pandemic and its prevention and control policies have impacted maternal and child health (MCH) services. This study documents the challenges faced by patients in accessing MCH services, and the experiences of health care providers in delivering those services during the COVID-19 outbreak, explicitly focusing on the lockdown period in India. METHODS: A cross-sectional study (rapid survey) was conducted in 18 districts from 6 states of India during March to June, 2020...
January 14, 2023: International Journal of Environmental Research and Public Health
#32
Saurabh Puri, Gulshan Singh Randhawa, Sukriti Bhasin, Rajat Aggarwal, Parkash Gera
Concomitant hepatitis A virus (HAV) and amoebic liver abscess are to be considered in patients with clinical signs and symptoms of fever, jaundice, and right upper quadrant pain, especially in endemic areas. Both diseases had similar epidemiology and identical mode of transmission, i.e., the feco-oral route. We report a case of a young female with simultaneous infection of HAV and amoebic liver abscess, emphasizing the role of dual infection and its clinical manifestations.
October 2022: Journal of Family Medicine and Primary Care
#33
JOURNAL ARTICLE
Waseem Abbas, Saurabh Gupta, Vineeta Goel, Anjali Aggarwal
To investigate the incidence of occult neck metastasis and to determine the prognostic factors related to the occurrence of the cervical lymph nodal metastasis and extra capsular extension (ECE) in early oral cavity cancer patients. A retrospective review performed on 100 patients with node negative squamous cell carcinoma of oral cavity who underwent primary treatment between Jan 2015 and Dec 2018. Incidence of occult neck metastasis after the elective neck dissection in our study was 35%. Independent correlates of positive occult neck metastasis were lymphovascular Invasion (P-0...
October 2022: Indian Journal of Otolaryngology and Head and Neck Surgery
#34
JOURNAL ARTICLE
Badal Sachendra, Chakrabarty Biswaroop, Aggarwal Bhawana, Bhatia Saurabh, Jauhari Prashant, Gupta Neerja, Kabra Madhulika, Gulati Sheffali
No abstract text is available yet for this article.
September 2022: Neurology India
#35
JOURNAL ARTICLE
Tulsi Adhikari, Sumit Aggarwal, Saritha Nair, Aparna Joshi, Vishal Diwan, A Stephen, K Rekha Devi, Bijaya Kumar Mishra, Girijesh Kumar Yadav, Sampada Dipak Bangar, Damodar Sahu, Jeetendra Yadav, Senthanro Ovung, Bal Kishan Gulati, Saurabh Sharma, Charan Singh, Chetna Duggal, Moina Sharma, Dhammasagar Ujagare, Sneha Padmakar Chinchore, Pricilla B Rebecca, S Rani, Pradeep Selvaraj, Gladston G Xavier, Vanessa Peter, Basilea Watson, T Kannan, K S Md Asmathulla, Debdutta Bhattacharya, Jyotirmayee Turuk, Subrata Kumar Palo, Srikanta Kanungo, Ajit Kumar Behera, Ashok Kumar Pandey, Kamran Zaman, Brij Ranjan Misra, Niraj Kumar, Sthita Pragnya Behera, Rajeev Singh, Kanwar Narain, Rajni Kant, Seema Sahay, Rajnarayan R Tiwari, Beena Elizabeth Thomas, M Vishnu Vardhana Rao
Objective: To assess factors associated with COVID-19 stigmatizing attitudes in the community and stigma experiences of COVID-19 recovered individuals during first wave of COVID-19 pandemic in India. Methods: A cross-sectional study was conducted in 18 districts located in 7 States in India during September 2020 to January 2021 among adults > 18 years of age selected through systematic random sampling. Data on socio demographic and COVID-19 knowledge were collected from 303 COVID-19 recovered and 1,976 non-COVID-19 infected individuals from community using a survey questionnaire...
2022: Frontiers in Public Health
#36
JOURNAL ARTICLE
Hafiz Adawi, Aparna Aggarwal, Saurabh Jain, Maha A Othman, Ahlam A A Othman, Rawan A Zakri, Somayah A M Namazi, Sara A Y Sori, Lamees H A Abuzawah, Zainab M Madkhali
The study aims to systematically review the available literature to evaluate the changes in oral microbiota in patients after bariatric surgery (BS) and correlates these alterations in microorganisms with common oral manifestations. Relevant Electronic databases were systematically searched for indexed English literature. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed for framework designing, application, and reporting of the current systematic review...
September 8, 2022: European Journal of Dentistry
#37
JOURNAL ARTICLE
Evgeny A Zemskov, Christine M Gross, Saurabh Aggarwal, Marina A Zemskova, Xiaomin Wu, Chenxin Gu, Ting Wang, Haiyang Tang, Stephen M Black
In acute lung injury (ALI), the NF-κB-mediated downregulation of Sox18 gene expression leads to the disruption of the pulmonary endothelial barrier. Previous studies have suggested that the action of NF-κB as a transcriptional repressor also requires the action of class I histone deacetylases (HDACs). Thus, the purpose of this study was to investigate and further delineate the mechanism of Sox18 repression during lipopolysaccharide (LPS) induced ALI. Using selective inhibitors and specific siRNA-driven depletion of HDACs 1-3 in human lung microvascular endothelial cells (HLMVEC) we were able to demonstrate a critical role for HDACs 1 and 2 in the LPS-mediated repression of Sox18 gene expression and the loss of endothelial monolayer integrity...
2022: Frontiers in Physiology
#38
JOURNAL ARTICLE
Saritha Nair, Aparna Joshi, Sumit Aggarwal, Tulsi Adhikari, Nupur Mahajan, Vishal Diwan, A Stephen, K Rekha Devi, Bijaya Kumar Mishra, Girijesh Kumar Yadav, Rewa Kohli, Damodar Sahu, Bal Kishan Gulati, Saurabh Sharma, Jeetendra Yadav, Senthanro Ovung, Chetna Duggal, Moina Sharma, Sampada Dipak Bangar, Rushikesh Andhalkar, Pricilla B Rebecca, S Rani, Pradeep Selvaraj, Gladston G Xavier, Vanessa Peter, Basilea Watson, T Kannan, K S Md Asmathulla, Debdutta Bhattacharya, Jyotirmayee Turuk, Subrata Kumar Palo, Srikanta Kanungo, Ajit Kumar Behera, Ashok Kumar Pandey, Kamran Zaman, Brij Ranjan Misra, Niraj Kumar, Sthita Pragnya Behera, Rajeev Singh, Abu Hasan Sarkar, Kanwar Narain, Rajni Kant, Seema Sahay, Rajnarayan Ramshankar Tiwari, Beena Elizabeth Thomas, Samiran Panda, M Vishnu Vardhana Rao
Background & objectives: COVID-19 pandemic has triggered social stigma towards individuals affected and their families. This study describes the process undertaken for the development and validation of scales to assess stigmatizing attitudes and experiences among COVID-19 and non-COVID-19 participants from the community. Methods: COVID-19 Stigma Scale and Community COVID-19 Stigma Scale constituting 13 and six items, respectively, were developed based on review of literature and news reports, expert committee evaluation and participants' interviews through telephone for a multicentric study in India...
January 2022: Indian Journal of Medical Research
#39
JOURNAL ARTICLE
Saritha Nair, Aparna Joshi, Sumit Aggarwal, Tulsi Adhikari, Nupur Mahajan, Vishal Diwan, A Stephen, K Rekha Devi, Bijaya Kumar Mishra, Girijesh Kumar Yadav, Rewa Kohli, Damodar Sahu, Bal Kishan Gulati, Saurabh Sharma, Jeetendra Yadav, Senthanro Ovung, Chetna Duggal, Moina Sharma, Sampada Dipak Bangar, Rushikesh Andhalkar, Pricilla B Rebecca, S Rani, Pradeep Selvaraj, Gladston G Xavier, Vanessa Peter, Basilea Watson, T Kannan, K S Md Asmathulla, Debdutta Bhattacharya, Jyotirmayee Turuk, Subrata Kumar Palo, Srikanta Kanungo, Ajit Kumar Behera, Ashok Kumar Pandey, Kamran Zaman, Brij Ranjan Misra, Niraj Kumar, Sthita Pragnya Behera, Rajeev Singh, Abu Hasan Sarkar, Kanwar Narain, Rajni Kant, Seema Sahay, Rajnarayan Ramshankar Tiwari, Beena Elizabeth Thomas, Samiran Panda, Vishnu Vardhana Rao
Background & objectives: COVID-19 pandemic has triggered social stigma towards individuals affected and their families. This study describes the process undertaken for the development and validation of scales to assess stigmatizing attitudes and experiences among COVID-19 and non-COVID-19 participants from the community. Methods: COVID-19 Stigma Scale and Community COVID-19 Stigma Scale constituting 13 and six items, respectively, were developed based on review of literature and news reports, expert committee evaluation and participants' interviews through telephone for a multicentric study in India...
May 20, 2022: Indian Journal of Medical Research
#40
JOURNAL ARTICLE
Selim Corbacioglu, Ozlem Topaloglu, Saurabh Aggarwal
BACKGROUND AND OBJECTIVES: Defibrotide is approved to treat severe veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) after haematopoietic cell transplantation in patients aged > 1 month in the European Union and for VOD/SOS with renal/pulmonary dysfunction post-haematopoietic cell transplantation in the United States. This meta-analysis estimated the incidence and risk of VOD/SOS after intravenous defibrotide prophylaxis using the published literature. METHODS: PubMed, Embase and Web of Science were searched through 30 November 2021 for defibrotide studies in VOD/SOS "prevention" or "prophylaxis," excluding phase I studies, case reports, studies with fewer than ten patients and reviews...
June 2022: Clinical Drug Investigation
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