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Saurabh aggarwal

James A Lambert, Matthew A Carlisle, Adam Lam, Saurabh Aggarwal, Stephen Doran, Changchun Ren, Wayne E Bradley, Louis Dell'Italia, Namasivayam Ambalavanan, David A Ford, Rakesh P Patel, Tamas Jilling, Sadis Matalon
Inhalation of oxidant gases has been implicated in adverse outcomes in pregnancy, but animal models to address mechanisms and studies to identify potential pregnancy-specific therapies are lacking. Herein, we show that inhalation of bromine at 600 parts per million for 30 minutes by pregnant mice on the 15th day of embryonic development results in significantly lower survival after 96 hours than an identical level of exposure in nonpregnant mice. On the 19th embryonic day, bromine-exposed pregnant mice have increased systemic blood pressure, abnormal placental development, severe fetal growth restriction, systemic inflammation, increased levels of circulating antiangiogenic short fms-like tyrosine kinase-1, and evidence of pulmonary and cardiac injury...
August 2017: Hypertension
Ankur Singh, Rajniti Prasad, Vidya Kumari Saurabh, Priyanka Aggarwal, Om Prakash Mishra
No abstract text is available yet for this article.
May 13, 2017: Indian Journal of Pediatrics
Adam Lam, Rohan Prabhu, Christine M Gross, Lee Ann Riesenberg, Vinodkumar Singh, Saurabh Aggarwal
Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the bacteria, Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB infections dating back to 5,800 B.C. TB is unique in its ability to remain latent in an individual for decades, with the possibility of later reactivation, causing widespread systemic symptoms. Currently, it is estimated that more than one-third of the world's population (about 2 billion people) are infected with Mtb. Prolonged periods of therapy and complexity of treatment regimens, especially in active infection, have led to poor compliance in patients being treated for TB...
May 11, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
Mahesh Anantha Narayanan, Saurabh Aggarwal, Yogesh N V Reddy, Venkata M Alla, Janani Baskaran, Arun Kanmanthareddy, Rakesh M Suri
Introduction Moderate mitral regurgitation (MR) of ischemic etiology has been associated with worse outcomes after coronary artery bypass grafting (CABG). Studies comparing concomitant mitral valve replacement/repair (MVR/Re) with CABG and standalone CABG have reported conflicting results. We performed a systematic review and meta-analysis of the published literature. Patients and Methods We searched using PubMed, Cochrane, EMBASE, CINAHL, and Google scholar databases from January 1960 to June 2016 for clinical trials comparing CABG to CABG + MVR/Re for moderate MR...
January 21, 2017: Thoracic and Cardiovascular Surgeon
Amitesh Aggarwal, Saurabh Srivastava, M Velmurugan
Coronary artery disease (CAD) occurring in less than 45 years of age is termed as young CAD. Recent studies show a prevalence of 1.2% of CAD cases in this age group. Ethnic wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%. Conventional risk factors such as smoking, diabetes, hypertension, obesity and family history seems to be as important as in older CAD subjects. But the prevalence of these risk factors seems to vary in younger subjects...
December 26, 2016: World Journal of Cardiology
D C Dhasmana, Suman Bala, Rajendra Sharma, Taruna Sharma, Saurabh Kohli, Neeraj Aggarwal, Juhi Kalra
OBJECTIVE: Viva voce examination is an important tool of evaluation in medical examinations marred by high subjectivity. Gross subjectivity in viva voce assessment can be reduced by structuring it. MATERIALS AND METHODS: The marks obtained in theory and viva voce (traditional viva voce examination [TVVE]) of I sessional, II MBBS students were compared and a huge disparity was identified. A structured viva voce examination (SVVE) was then proposed and experimented as an objective and standardized alternative...
October 2016: Indian Journal of Pharmacology
Rohit S Loomba, Matthew W Buelow, Saurabh Aggarwal, Rohit R Arora, Joshua Kovach, Salil Ginde
INTRODUCTION: An increasing number of patients with congenital heart disease are now surviving into adulthood. This has also led to the emergence of complications from the underlying congenital heart disease, related surgical interventions, and associated combordities. While the prevalence of particular arrhythmias with specific congenital heart disease has been previously described, a detailed analysis of all lesions and a large number of comorbidities has not been previously published...
December 16, 2016: Pacing and Clinical Electrophysiology: PACE
Rohit S Loomba, Karan Nijhawan, Saurabh Aggarwal, Rohit R Arora
No abstract text is available yet for this article.
September 9, 2016: American Journal of Therapeutics
Clint Allred, Kathryn Berlacher, Saurabh Aggarwal, Alex J Auseon
BACKGROUND: Cardiology fellowship programs are at the interface of medical education and the care of patients suffering from the leading cause of mortality in the United States, yet there is an apparent lack of research guiding the effective education of fellows. OBJECTIVE: We sought to quantify the number of publications in cardiology journals that pertained to the education of cardiology trainees and the number of cardiologists participating in education research...
July 2016: Journal of Graduate Medical Education
Saurabh Aggarwal, Praveen Mannam, Jianhua Zhang
Lysosomal-mediated degradation of intracellular lipids, proteins and organelles, known as autophagy, represents a inducible adaptive response to lung injury resulting from exposure to insults, such as hypoxia, microbes, inflammation, ischemia-reperfusion, pharmaceuticals (e.g., bleomycin), or inhaled xenobiotics (i.e., air pollution, cigarette smoke). This process clears damaged or toxic cellular constituents and facilitates cell survival in stressful environments. Autophagic degradation of dysfunctional or damaged mitochondria is termed mitophagy...
August 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
Matthew Carlisle, Adam Lam, Erik R Svendsen, Saurabh Aggarwal, Sadis Matalon
Chlorine (Cl2 ) is utilized worldwide for a diverse range of industrial applications, including pulp bleaching, sanitation, and pharmaceutical development. Though Cl2 has widespread use, little is known regarding the mechanisms of toxicity associated with Cl2 exposure, which occurs during industrial accidents or acts of terrorism. Previous instances of Cl2 exposure have led to reported episodes of respiratory distress that result in high morbidity and mortality. Furthermore, studies suggest that acute Cl2 exposure also results in systemic vascular injury and subsequent myocardial contractile dysfunction...
June 2016: Annals of the New York Academy of Sciences
Adam Lam, Nilam Vetal, Sadis Matalon, Saurabh Aggarwal
Bromine (Br2 ) gas inhalation poses an environmental and occupational hazard resulting in high morbidity and mortality. In this review, we underline the acute lung pathology (within 24 h of exposure) and potential therapeutic interventions that may be utilized to mitigate Br2 -induced human toxicity. We discuss our latest published data, which suggest that an increase in heme-dependent tissue injury underlies the pathogenesis of Br2 toxicity. Our study was based on previous findings that demonstrated that Br2 upregulates the heme-degrading enzyme heme oxygenase-1 (HO-1), which converts toxic heme into bilverdin...
June 2016: Annals of the New York Academy of Sciences
Rohit S Loomba, Saurabh Aggarwal, Rohit R Arora, Robert Anderson
INTRODUCTION: Bodily isomerism, or heterotaxy is a unique entity on which there is mirror imagery in various organ systems, leading to a deviation from the normal lateral arrangements of the viscera. Adults with such isomerism and associated congenital malformations of the heart are now reaching adulthood and developing long-term complications. This study investigates the prevalence and characteristics of pulmonary hypertension in adults with isomerism. METHODS: The 2012 iteration of the Nationwide Inpatient Sample was utilized and patients were identified as having or not having bodily isomerism and having or not having pulmonary hypertension...
June 2016: Therapeutic Advances in Respiratory Disease
Olga Rafikova, Ruslan Rafikov, Archana Kangath, Ning Qu, Saurabh Aggarwal, Shruti Sharma, Julin Desai, Taylor Fields, Britta Ludewig, Jason X-Y Yuan, Danny Jonigk, Stephen M Black
The development of pulmonary hypertension (PH) involves the uncontrolled proliferation of pulmonary smooth muscle cells via increased growth factor receptor signaling. However, the role of epidermal growth factor receptor (EGFR) signaling is controversial, as humans with advanced PH exhibit no changes in EGFR protein levels and purpose of the present study was to determine whether there are post-translational mechanisms that enhance EGFR signaling in PH. The EGFR inhibitor, gefinitib, significantly attenuated EGFR signaling and prevented the development of PH in monocrotaline (MCT)-exposed rats, confirming the contribution of EGFR activation in MCT induced PH...
June 2016: Free Radical Biology & Medicine
Rohit S Loomba, Saurabh Aggarwal, Matthew Buelow, Karan Nijhawan, Navdeep Gupta, Venkata Alla, Rohit R Arora
INTRODUCTION: Children born with congenital malformations of the heart are increasingly surviving into adulthood. This population of patients possesses lesion-specific complication risks while still being at risk for common illnesses. Bodily isomerism or heterotaxy, is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of myocardial infarction in adults with bodily isomerism...
December 2016: Congenital Heart Disease
Saurabh Aggarwal, Manoj Kumar Mahapatra, Rajnish Kumar, Tilak R Bhardwaj, Rolf W Hartmann, Jörg Haupenthal, Manoj Kumar
In the present study, a series of steroidal tetrazole derivatives of androstane and pregnane have been prepared in which the tetrazole moiety was appended at C-3 and 17a-aza locations. 3-Tetrazolo-3,5-androstadien-17-one (6), 3-tetrazolo-19-nor-3,5-androstadien-17-one (10), 3-tetrazolo-3,5-pregnadien-20-one (14), 17a-substituted 3-tetrazolo-17a-aza-D-homo-3,5-androstadien-17-one (26-31) and 3-(2-acetyltetrazolo)-17a-aza-d-homo-3,5-androstadien-17-one (32) were synthesized from dehydroepiandrosterone acetate (1) through multiple synthetic steps...
February 15, 2016: Bioorganic & Medicinal Chemistry
Saurabh Aggarwal, Pankaj Malhotra, Sunil Dogra, Keshavamurthy Vinay, Amrinder J Kanwar, Uma N Saikia
BACKGROUND: Literature on cutaneous manifestations of leukemia is limited. OBJECTIVE: To determine the pattern of mucocutaneous manifestations in adult Asian patients with leukemia and to establish their relation with the leukemia type. SUBJECTS AND METHODS: After previous consent, 196 consecutively registered patients with leukemia aged ≥18 years were recruited. All patients were prospectively followed for 3 months to evaluate the patterns of mucocutaneous involvement...
August 2016: International Journal of Dermatology
Saurabh Aggarwal, Rohit S Loomba, Rohit R Arora
Clopidogrel is a widely used drug in clinical practice. Controversy persists as to whether it interacts with proton pump inhibitors. Recently, research interest has grown in the area concerning an interaction of clopidogrel with calcium channel blockers. Multiple studies have been conducted to evaluate the effect of calcium channel blockers on the efficacy of clopidogrel, both in vitro and in vivo. The authors aim to present a systematic review of the published studies in the literature. Various terms were searched in PubMed, Web of Science, and The Cochrane database...
January 2016: American Journal of Therapeutics
Navkaranbir S Bajaj, Rajat Kalra, Himanshu Aggarwal, Sameer Ather, Saurabh Gaba, Garima Arora, David C McGiffin, Mustafa Ahmed, Stella Aslibekyan, Pankaj Arora
BACKGROUND: Significant controversy exists regarding the best approach for nonculprit vessel revascularization in patients with multivessel coronary artery disease presenting with ST-segment elevation myocardial infarction. We conducted a systematic investigation to pool data from current randomized controlled trials (RCTs) to assess optimal treatment strategies in this patient population. METHODS AND RESULTS: A comprehensive search of SCOPUS from inception through May 2015 was performed using predefined criteria...
December 14, 2015: Journal of the American Heart Association
Imtiaz Ismail, Khalid Al-Khafaji, Monica Mutyala, Saurabh Aggarwal, William Cotter, Hosam Hakim, Sandeep Khosla, Rohit Arora
Lipomas of the heart are encapsulated tumors that are composed primarily of mature fat cells. Cardiac lipomas can originate either from subendocardium (approximately 50%), subpericardium (25%), or from the myocardium (25%) and may be located more frequently in left ventricle or right atrium. We report a 74-year-old female who presented with dyspnea on exertion and was found to have 5×5 cm mass occupying most of the right atrium on a transesophageal echocardiogram.
2015: Journal of Community Hospital Internal Medicine Perspectives
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