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Saurabh aggarwal

Rohit S Loomba, Karan Nijhawan, Saurabh Aggarwal, Rohit R Arora
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September 9, 2016: American Journal of Therapeutics
Clint Allred, Kathryn Berlacher, Saurabh Aggarwal, Alex J Auseon
BACKGROUND: Cardiology fellowship programs are at the interface of medical education and the care of patients suffering from the leading cause of mortality in the United States, yet there is an apparent lack of research guiding the effective education of fellows. OBJECTIVE: We sought to quantify the number of publications in cardiology journals that pertained to the education of cardiology trainees and the number of cardiologists participating in education research...
July 2016: Journal of Graduate Medical Education
Saurabh Aggarwal, Praveen Mannam, Jianhua Zhang
Lysosomal-mediated degradation of intracellular lipids, proteins and organelles, known as autophagy, represents a inducible adaptive response to lung injury resulting from exposure to insults, such as hypoxia, microbes, inflammation, ischemia-reperfusion, pharmaceuticals (e.g., bleomycin), or inhaled xenobiotics (i.e., air pollution, cigarette smoke). This process clears damaged or toxic cellular constituents and facilitates cell survival in stressful environments. Autophagic degradation of dysfunctional or damaged mitochondria is termed mitophagy...
August 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
Matthew Carlisle, Adam Lam, Erik R Svendsen, Saurabh Aggarwal, Sadis Matalon
Chlorine (Cl2 ) is utilized worldwide for a diverse range of industrial applications, including pulp bleaching, sanitation, and pharmaceutical development. Though Cl2 has widespread use, little is known regarding the mechanisms of toxicity associated with Cl2 exposure, which occurs during industrial accidents or acts of terrorism. Previous instances of Cl2 exposure have led to reported episodes of respiratory distress that result in high morbidity and mortality. Furthermore, studies suggest that acute Cl2 exposure also results in systemic vascular injury and subsequent myocardial contractile dysfunction...
June 2016: Annals of the New York Academy of Sciences
Adam Lam, Nilam Vetal, Sadis Matalon, Saurabh Aggarwal
Bromine (Br2 ) gas inhalation poses an environmental and occupational hazard resulting in high morbidity and mortality. In this review, we underline the acute lung pathology (within 24 h of exposure) and potential therapeutic interventions that may be utilized to mitigate Br2 -induced human toxicity. We discuss our latest published data, which suggest that an increase in heme-dependent tissue injury underlies the pathogenesis of Br2 toxicity. Our study was based on previous findings that demonstrated that Br2 upregulates the heme-degrading enzyme heme oxygenase-1 (HO-1), which converts toxic heme into bilverdin...
June 2016: Annals of the New York Academy of Sciences
Rohit S Loomba, Saurabh Aggarwal, Rohit R Arora, Robert Anderson
INTRODUCTION: Bodily isomerism, or heterotaxy is a unique entity on which there is mirror imagery in various organ systems, leading to a deviation from the normal lateral arrangements of the viscera. Adults with such isomerism and associated congenital malformations of the heart are now reaching adulthood and developing long-term complications. This study investigates the prevalence and characteristics of pulmonary hypertension in adults with isomerism. METHODS: The 2012 iteration of the Nationwide Inpatient Sample was utilized and patients were identified as having or not having bodily isomerism and having or not having pulmonary hypertension...
June 2016: Therapeutic Advances in Respiratory Disease
Olga Rafikova, Ruslan Rafikov, Archana Kangath, Ning Qu, Saurabh Aggarwal, Shruti Sharma, Julin Desai, Taylor Fields, Britta Ludewig, Jason X-Y Yuan, Danny Jonigk, Stephen M Black
The development of pulmonary hypertension (PH) involves the uncontrolled proliferation of pulmonary smooth muscle cells via increased growth factor receptor signaling. However, the role of epidermal growth factor receptor (EGFR) signaling is controversial, as humans with advanced PH exhibit no changes in EGFR protein levels and purpose of the present study was to determine whether there are post-translational mechanisms that enhance EGFR signaling in PH. The EGFR inhibitor, gefinitib, significantly attenuated EGFR signaling and prevented the development of PH in monocrotaline (MCT)-exposed rats, confirming the contribution of EGFR activation in MCT induced PH...
June 2016: Free Radical Biology & Medicine
Rohit S Loomba, Saurabh Aggarwal, Matthew Buelow, Karan Nijhawan, Navdeep Gupta, Venkata Alla, Rohit R Arora
INTRODUCTION: Children born with congenital malformations of the heart are increasingly surviving into adulthood. This population of patients possesses lesion-specific complication risks while still being at risk for common illnesses. Bodily isomerism or heterotaxy, is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of myocardial infarction in adults with bodily isomerism...
February 16, 2016: Congenital Heart Disease
Saurabh Aggarwal, Manoj Kumar Mahapatra, Rajnish Kumar, Tilak R Bhardwaj, Rolf W Hartmann, Jörg Haupenthal, Manoj Kumar
In the present study, a series of steroidal tetrazole derivatives of androstane and pregnane have been prepared in which the tetrazole moiety was appended at C-3 and 17a-aza locations. 3-Tetrazolo-3,5-androstadien-17-one (6), 3-tetrazolo-19-nor-3,5-androstadien-17-one (10), 3-tetrazolo-3,5-pregnadien-20-one (14), 17a-substituted 3-tetrazolo-17a-aza-D-homo-3,5-androstadien-17-one (26-31) and 3-(2-acetyltetrazolo)-17a-aza-d-homo-3,5-androstadien-17-one (32) were synthesized from dehydroepiandrosterone acetate (1) through multiple synthetic steps...
February 15, 2016: Bioorganic & Medicinal Chemistry
Saurabh Aggarwal, Pankaj Malhotra, Sunil Dogra, Keshavamurthy Vinay, Amrinder J Kanwar, Uma N Saikia
BACKGROUND: Literature on cutaneous manifestations of leukemia is limited. OBJECTIVE: To determine the pattern of mucocutaneous manifestations in adult Asian patients with leukemia and to establish their relation with the leukemia type. SUBJECTS AND METHODS: After previous consent, 196 consecutively registered patients with leukemia aged ≥18 years were recruited. All patients were prospectively followed for 3 months to evaluate the patterns of mucocutaneous involvement...
August 2016: International Journal of Dermatology
Saurabh Aggarwal, Rohit S Loomba, Rohit R Arora
Clopidogrel is a widely used drug in clinical practice. Controversy persists as to whether it interacts with proton pump inhibitors. Recently, research interest has grown in the area concerning an interaction of clopidogrel with calcium channel blockers. Multiple studies have been conducted to evaluate the effect of calcium channel blockers on the efficacy of clopidogrel, both in vitro and in vivo. The authors aim to present a systematic review of the published studies in the literature. Various terms were searched in PubMed, Web of Science, and The Cochrane database...
January 2016: American Journal of Therapeutics
Navkaranbir S Bajaj, Rajat Kalra, Himanshu Aggarwal, Sameer Ather, Saurabh Gaba, Garima Arora, David C McGiffin, Mustafa Ahmed, Stella Aslibekyan, Pankaj Arora
BACKGROUND: Significant controversy exists regarding the best approach for nonculprit vessel revascularization in patients with multivessel coronary artery disease presenting with ST-segment elevation myocardial infarction. We conducted a systematic investigation to pool data from current randomized controlled trials (RCTs) to assess optimal treatment strategies in this patient population. METHODS AND RESULTS: A comprehensive search of SCOPUS from inception through May 2015 was performed using predefined criteria...
December 2015: Journal of the American Heart Association
Imtiaz Ismail, Khalid Al-Khafaji, Monica Mutyala, Saurabh Aggarwal, William Cotter, Hosam Hakim, Sandeep Khosla, Rohit Arora
Lipomas of the heart are encapsulated tumors that are composed primarily of mature fat cells. Cardiac lipomas can originate either from subendocardium (approximately 50%), subpericardium (25%), or from the myocardium (25%) and may be located more frequently in left ventricle or right atrium. We report a 74-year-old female who presented with dyspnea on exertion and was found to have 5×5 cm mass occupying most of the right atrium on a transesophageal echocardiogram.
2015: Journal of Community Hospital Internal Medicine Perspectives
Rohit S Loomba, Saurabh Aggarwal, Navdeep Gupta, Matthew Buelow, Venkata Alla, Rohit R Arora, Robert H Anderson
There are an increasing number of adults with congenital heart disease, some of whom have bodily isomerism. Bodily isomerism or heterotaxy is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of arrhythmias in adults with bodily isomerism. We utilized the 2012 iteration of the Nationwide Inpatient Sample to identify adult inpatient admissions associated with arrhythmias in patients with isomerism...
February 2016: Pediatric Cardiology
Rohit Seth Loomba, Karan Nijhawan, Saurabh Aggarwal, Rohit Romesh Arora
INTRODUCTION: Current guidelines for the management of out-of-hospital cardiac arrest (OHCA) recommend the use of prehospital epinephrine by initial responders. This recommendation was initially based on data from animal models of cardiac arrest and minimal human data, but since its inception, more human data regarding prehospital epinephrine in this setting are now available. Although out-of-hospital return of spontaneous circulation (ROSC) may be higher with the use of epinephrine, worse neurologic outcomes may be associated with its use...
December 2015: Journal of Critical Care
Saurabh Aggarwal, Adam Lam, Subhashini Bolisetty, Matthew A Carlisle, Amie Traylor, Anupam Agarwal, Sadis Matalon
AIMS: Exposure to irritant gases, such as bromine (Br2), poses an environmental and occupational hazard that results in severe lung and systemic injury. However, the mechanism(s) of Br2 toxicity and the therapeutic responses required to mitigate lung damage are not known. Previously, it was demonstrated that Br2 upregulates the heme degrading enzyme, heme oxygenase-1 (HO-1). Since heme is a major inducer of HO-1, we determined whether an increase in heme and heme-dependent oxidative injury underlies the pathogenesis of Br2 toxicity...
January 10, 2016: Antioxidants & Redox Signaling
Rohit S Loomba, Karan Nijhawan, Saurabh Aggarwal, Rohit R Arora
INTRODUCTION: Supplemental oxygen has been used in the setting of acute myocardial infarction (AMI). Once an official recommendation in the guidelines for the management of acute ST-segment elevation myocardial infarction, it is now mentioned as an intervention to be considered. Data for the use of supplemental oxygen or AMI are limited, and some data have suggested associated harm. METHODS: We performed a systematic review of the literature and a subsequent meta-analysis of the data to determine the effect of high concentration oxygen versus titrated oxygen or room air in the setting of AMI...
March 2016: Journal of Cardiovascular Pharmacology and Therapeutics
Clarissa J Diamantidis, Jennifer S Ginsberg, Marni Yoffe, Lisa Lucas, Divya Prakash, Saurabh Aggarwal, Wanda Fink, Stefan Becker, Jeffrey C Fink
BACKGROUND AND OBJECTIVES: Inappropriate medication use is common in the care of patients with CKD. The feasibility of a simple mobile health tool designed to advise patients on safe medication usage in CKD was examined. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Participants with predialysis CKD (defined as eGFR<60 ml/min per 1.73 m(2)) in the Safe Kidney Care Cohort Study were recruited for home usability testing of a novel medication inquiry system between January and September of 2013...
August 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
Imtiaz Ismail, Khalid Al-Khafaji, Monica Mutyala, Saurabh Aggarwal, Nawfal Al-Khafaji, Daniela Kovacs, Sandeep Khosla, Rohit Arora
Moyamoya disease is a rare neurological condition that affects children and adults of all ages. It is characterized by chronic, progressive stenosis of the circle of Willis that ultimately leads to the development of extensive collateral vessels. Presenting symptoms are usually due to cerebral ischemia or hemorrhage. The Japanese term moyamoya (meaning puffy or obscure) was coined to describe the characteristic 'smoke in the air' appearance of these vessels on cerebral angiography. Moyamoya has the highest recorded incidence in Japan (0...
2015: Journal of Community Hospital Internal Medicine Perspectives
Shilpi Aggarwal, Atish Gheware, Anurag Agrawal, Saurabh Ghosh, Bhavana Prasher, Mitali Mukerji
BACKGROUND: Extreme constitution "Prakriti" types of Ayurveda exhibit systemic physiological attributes. Our earlier genetic study has revealed differences in EGLN1, key modulator of hypoxia axis between Prakriti types. This was associated with differences in high altitude adaptation and susceptibility to high altitude pulmonary edema (HAPE). In this study we investigate other molecular differences that contribute to systemic attributes of Prakriti that would be relevant in predictive marker discovery...
June 6, 2015: Journal of Translational Medicine
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