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Aiman Smer, Mohsin Salih, Toufik Mahfood Haddad, Raviteja Guddeti, Abdulghani Saadi, Alok Saurav, Ram Belbase, Mohamed Ayan, Mahmoud Traina, Venkata Alla, Michael Del Core
The optimal management of patients with cryptogenic stroke (CS) and patent foramen ovale (PFO) remains controversial. We conducted a meta-analysis to assess the effect of PFO closure for secondary prevention of stroke on patients with CS. We searched the literature for randomized control trials assessing the recurrence of stroke after PFO closure compared with medical therapy (antiplatelet and/or anticoagulation). Five randomized control trials with a total of 3,440 patients were included. The mean age was 45...
June 1, 2018: American Journal of Cardiology
Geetanjali Dang, Mohammed Saleh, Tarun Tandon, Gopi Sirineni, Venkata Mahesh Alla
No abstract text is available yet for this article.
June 1, 2018: European Heart Journal Cardiovascular Imaging
Toufik Mahfood Haddad, Alok Saurav, Aiman Smer, Muhammad S Azzouz, Abhilash Akinapelli, Mark A Williams, Venkata M Alla
PURPOSE: Exercise-based cardiac rehabilitation (EBCR) has been demonstrated to improve functional capacity in heart failure (HF). However, there are limited data on the effect of EBCR in patients with advanced HF and left ventricular assist devices (LVADs). This meta-analysis sought to evaluate the effects of EBCR on functional capacity in patients with LVAD. METHODS: PubMed, Web of Science, CINAHL, and Cochrane Library databases were searched for randomized studies assessing the impact of EBCR in patients following LVAD implantation compared with standard therapy (ST)...
November 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
Mahesh Anantha Narayanan, Saurabh Aggarwal, Yogesh N V Reddy, Venkata M Alla, Janani Baskaran, Arun Kanmanthareddy, Rakesh M Suri
Introduction Moderate mitral regurgitation (MR) of ischemic etiology has been associated with worse outcomes after coronary artery bypass grafting (CABG). Studies comparing concomitant mitral valve replacement/repair (MVR/Re) with CABG and standalone CABG have reported conflicting results. We performed a systematic review and meta-analysis of the published literature. Patients and Methods We searched using PubMed, Cochrane, EMBASE, CINAHL, and Google scholar databases from January 1960 to June 2016 for clinical trials comparing CABG to CABG + MVR/Re for moderate MR...
September 2017: Thoracic and Cardiovascular Surgeon
Toufik Mahfood Haddad, Shadi Hamdeh, Arun Kanmanthareddy, Venkata M Alla
OBJECTIVE: Numerous studies have assessed the association between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, results have been conflicting due to variability in definitions of NAFLD and ascertainment of CVD, often combining clinical and surrogate endpoints. We therefore systematically reviewed published literature to assess the association between NAFLD and clinical cardiovascular events (CVE) and performed a meta-analysis. METHODS: We searched PubMed, Medline, Cochrane, CINAHL, and Web of Science databases using terms "nonalcoholic fatty liver disease", "nonalcoholic steatohepatitis", "cardiovascular disease", and their combinations to identify prospective studies published from inception through March 2016...
December 15, 2016: Diabetes & Metabolic Syndrome
Alok Saurav, Aiman Smer, Abhilash Akinapelli, Arun Kanmanthareddy, Muhammad Azzouz, Manu Kaushik, Himanshu Agarwal, Michael White, Venkata M Alla, Claire C Hunter, Syed Mohiuddin, Michael Delcore, Aryan Mooss, Dennis Esterbrooks
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
Aiman Smer, Venkata M Alla, Hussam Abuissa
CLINICAL INTRODUCTION: A 50-year-old white male with a history of paroxysmal atrial fibrillation presented for transoesophageal echocardiogram prior to atrial fibrillation ablation. However, an echo lucent mass was noted (figure 1A). Colour Doppler and contrast administration showed no flow across the mass or the interatrial septum (see online supplementary videos 1 and 2). CT of the chest demonstrated a thin-walled, well-demarcated mass in the inferior border of the fossa ovalis protruding into the left atrium (figure 1B)...
February 2017: Heart: Official Journal of the British Cardiac Society
(no author information available yet)
BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. METHODS: For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes...
August 2016: Lancet HIV
Rohit S Loomba, Saurabh Aggarwal, Matthew Buelow, Karan Nijhawan, Navdeep Gupta, Venkata Alla, Rohit R Arora
INTRODUCTION: Children born with congenital malformations of the heart are increasingly surviving into adulthood. This population of patients possesses lesion-specific complication risks while still being at risk for common illnesses. Bodily isomerism or heterotaxy, is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of myocardial infarction in adults with bodily isomerism...
December 2016: Congenital Heart Disease
Rohit S Loomba, Saurabh Aggarwal, Navdeep Gupta, Matthew Buelow, Venkata Alla, Rohit R Arora, Robert H Anderson
There are an increasing number of adults with congenital heart disease, some of whom have bodily isomerism. Bodily isomerism or heterotaxy is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of arrhythmias in adults with bodily isomerism. We utilized the 2012 iteration of the Nationwide Inpatient Sample to identify adult inpatient admissions associated with arrhythmias in patients with isomerism...
February 2016: Pediatric Cardiology
Alok Saurav, Manu Kaushik, Venkata Mahesh Alla, Michael D White, Ruby Satpathy, Thomas Lanspa, Aryan N Mooss, Michael G DelCore
BACKGROUND: While percutaneous device closure (PDC) is a first-line therapy for isolated muscular ventricular septal defects (mVSD), surgery is still the preferred approach for peri-membranous ventricular septal defects (pmVSD). OBJECTIVE: We sought to compare the outcomes of percutaneous versus open surgical closure of pmVSDs. METHODS: PubMed, Cochrane Library, and Web of Science databases were searched through October 15, 2014 for English language studies comparing outcomes of PDC with surgical closure of pmVSDs...
November 15, 2015: Catheterization and Cardiovascular Interventions
Aiman Smer, Mahesh Anantha Narayanan, Toufik Mahfood Haddad, Harish Devineni, Venkata Alla
No abstract text is available yet for this article.
July 2015: American Journal of Emergency Medicine
Manda Bhaskar Reddy, Myadaraboina Shailaja, Alla Manjula, Joseph Richard Premkumar, Garikapati Narahari Sastry, Katukuri Sirisha, Akella Venkata Subrahmanya Sarma
Two flexible Tröger's base ditopic receptors C4TB and C5TB incorporating monoaza crown ether were designed and synthesized for bisammonium ion complexation. A comprehensive study of host-guest interactions was established by (1)H NMR spectroscopy and DFT calculations. Bisammonium chloride (A1) with a shorter alkyl chain spacer showed the highest affinity for the receptors. M06-2X/cc-pVTZ calculations including the solvent effects on host-guest complexes were employed to explain and rationalize the experimental trends...
January 28, 2015: Organic & Biomolecular Chemistry
Alok Saurav, Venkata Mahesh Alla, Manu Kaushik, Claire C Hunter, Aryan V Mooss
Long-term superiority of mitral valve (MV) repair compared with replacement is well established in degenerative MV disease. In rheumatic heart disease, its advantages are unclear and it is often performed in conjunction with aortic valve (AV) replacement. Herein, we performed a systematic review and meta-analysis comparing outcomes of MV repair vs replacement in patients undergoing concomitant AV replacement. PubMed, Cochrane and Web of Science databases were searched up to 25 January 2014 for English language studies comparing outcomes of MV repair vs replacement in patients undergoing simultaneous AV replacement...
September 2015: European Journal of Cardio-thoracic Surgery
Aiman Smer, Venkata Alla, Satish Chandraprakasam, Ahmed Abuzaid, Alok Saurav, Jeffery Holmberg
Saphenous vein graft (SVG) pseudoaneurysm is a rare complication of coronary artery bypass graft (CABG) surgery. A review of literature indicates that almost one third of patients are asymptomatic at detection and a history of operative complications and need for re-exploration after the initial surgery may serve as useful predictors for the development of this rare complication.
January 2015: Journal of Cardiac Surgery
Sreevani Rapolu, Manjula Alla, Vittal Rao Bommena, Ramalinga Murthy, Nishant Jain, Venkata Ramya Bommareddy, Madhava Reddy Bommineni
A series of 5-(alkyl(1H-indol-3-yl))-2-(substituted)-1,3,4-oxadiazoles were efficiently synthesized by oxidative cyclisation of N'-benzylidene-(1H-indol-3-yl)alkane hydrazides using di(acetoxy)iodobenzene. N'-Benzylidene-(1H-indol-3-yl)alkane hydrazides themselves were derived from simple indole-3-carboxylic acids. The 5-(alkyl(1H-indol-3-yl))-2-(substituted)-1,3,4-oxadiazoles were evaluated for their anti-inflammatory and anti-proliferative activities. Based on the results obtained structure and activity relationship (SAR) was established and a correlation between the activities was observed...
August 2013: European Journal of Medicinal Chemistry
Venkata M Alla, Vrinda Agrawal, Andrew DeNazareth, Syed Mohiuddin, Sudha Ravilla, Marc Rendell
Atherosclerotic cardiovascular disease (CVD) is the number one cause of death globally, and lipid modification, particularly lowering of low density lipoprotein cholesterol (LDLc), is one of the cornerstones of prevention and treatment. However, even after lowering of LDLc to conventional goals, a sizeable number of patients continue to suffer cardiovascular events. More aggressive lowering of LDLc and optimization of other lipid parameters like triglycerides (TG) and high density lipoprotein cholesterol (HDLc) have been proposed as two potential strategies to address this residual risk...
July 2013: Drugs
Rajashekar R Gurrala, Venkata Mb Alla, Wilbert S Aronow, Jai S Shankar, Meena K Angamutta, Krishna Lanka, Sundaram Challa, Chandra K Nair
The myocardial performance index (MPI) was assessed in 30 patients with limb girdle muscle dystrophy (LGMD) with a normal left ventricular ejection fraction (greater than 50%), as well as in 30 age- and sex-matched healthy adults with a left ventricular ejection fraction greater than 50%. MPIs derived by pulsed-wave Doppler and tissue Doppler were also compared. The MPI was 0.37±0.09 in the LGMD patients and 0.29±0.09 in the control group (P=0.003). These data show that patients with LGMD have occult cardiac dysfunction as evidenced by a higher MPI than the controls...
2007: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
Andrew G Denazareth, Venkata M Alla, Stephen J Lanspa
No abstract text is available yet for this article.
February 2012: Western Journal of Emergency Medicine
Anand Deshmukh, Kyle Ulveling, Venkata Alla, Hussam Abuissa, Kelly Airey
Citalopram is a selective serotonin reuptake inhibitor with a favorable cardiac-safety profile. Corrected QT interval (QTc) prolongation and cardiac arrhythmias have not been previously reported in association with citalopram use except in the presence of overdose, abnormal electrolyte values, or renal or liver failure. Herein, we report the case of a 40-year-old woman with mental depression who presented with a prolonged QTc interval and torsades de pointes after the initiation of citalopram at therapeutic doses...
2012: Texas Heart Institute Journal
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