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https://www.readbyqxmd.com/read/28711447/the-transition-from-hypertension-to%C3%A2-heart%C3%A2-failure-contemporary-update
#1
REVIEW
Franz H Messerli, Stefano F Rimoldi, Sripal Bangalore
Longstanding hypertension ultimately leads to heart failure (HF), and as a consequence most patients with HF have a history of hypertension. Conversely, absence of hypertension in middle age is associated with lower risks for incident HF across the remaining life course. Cardiac remodeling to a predominant pressure overload consists of diastolic dysfunction and concentric left ventricular (LV) hypertrophy. When pressure overload is sustained, diastolic dysfunction progresses, filling of the concentric remodeled LV decreases, and HF with preserved ejection fraction ensues...
July 6, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28681519/blood-pressure-control-and-mortality-in-us-and-foreign-born-blacks-in-new-york-city
#2
Joyce Gyamfi, Mark Butler, Stephen K Williams, Charles Agyemang, Lloyd Gyamfi, Azizi Seixas, Grace Melinda Zinsou, Sripal Bangalore, Nirav R Shah, Gbenga Ogedegbe
This retrospective cohort study compared blood pressure (BP) control (BP <140/90 mm Hg) and all-cause mortality between US- and foreign-born blacks. We used data from a clinical data warehouse of 41 868 patients with hypertension who received care in a New York City public healthcare system between 2004 and 2009, defining BP control as the last recorded BP measurement and mean BP control. Poisson regression demonstrated that Caribbean-born blacks had lower BP control for the last BP measurement compared with US- and West African-born blacks, respectively (49% vs 54% and 57%; P<...
July 6, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28623176/duration-of-dual-anti-platelet-therapy-in-patients-with-an-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention-a-meta-analysis-of-randomized-controlled-trials
#3
Chirag Bavishi, Vrinda Trivedi, Mandeep Singh, Edward Katz, Franz H Messerli, Sripal Bangalore
BACKGROUND: The recent AHA/ACC guidelines on duration of dual anti-platelet therapy (DAPT) recommend DAPT for 1 year in patients presenting with an acute coronary syndrome, with a Class IIb recommendation for continuation. We aim to assess the evidence for these recommendations using a meta-analytic approach. METHODS: We searched electronic databases for randomized trials comparing short-term (≤6 months) vs 12 months vs extended (>12 months) DAPT in patients with an acute coronary syndrome undergoing percutaneous coronary intervention...
June 13, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28616307/pci-or-cabg-for-severe-unprotected-left-main-coronary-artery-disease-making-sense-of-the-noble-and-excel-trials
#4
EDITORIAL
Anthony A Holmes, Sripal Bangalore
No abstract text is available yet for this article.
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28559492/angiotensin-receptor-blockers-reduce-cardiovascular-events-including-the-risk-of-myocardial-infarction
#5
Franz H Messerli, Sripal Bangalore
No abstract text is available yet for this article.
May 30, 2017: Circulation
https://www.readbyqxmd.com/read/28530520/cardiovascular-disease-and-gout-real-world-experience-evaluating-patient-characteristics-treatment-patterns-and-health-care-utilization
#6
Michael H Pillinger, Sripal Bangalore, Alyssa B Klein, Scott Baumgartner, Robert Morlock
BACKGROUND: Gout, hyperuricemia, and cardiovascular disease (CVD) are prevalent conditions in the United States, and while they share common risk factors such as obesity, hypertension, hypercholesterolemia, and type 2 diabetes mellitus, relatively little is known about what patient and disease characteristics may link CVD with hyperuricemia and gout and how the presence of both diseases affects management decisions differently than for patients with gout alone. OBJECTIVE: To identify differences in patient characteristics, patterns of urate-lowering therapy (ULT) use, and gout control in gout patients with and without cardiovascular comorbidity...
June 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28488237/perioperative-bleeding-and-thrombotic-risks-in-patients-with-von-willebrand-disease
#7
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Sripal Bangalore, Jeffrey S Berger
Von Willebrand disease (VWD) is an inherited bleeding disorder that often manifests clinically with hemorrhage after invasive procedures. We investigated the association between a diagnosis of VWD and bleeding and thrombotic outcomes following major non-cardiac surgery in a large national database from the United States. Patients age ≥45 years requiring major non-cardiac surgery were identified from Healthcare Cost and Utilization Project's National Inpatient Sample data. Von Willebrand disease, perioperative major adverse cardiovascular events (MACE), thrombotic events, and hemorrhage were defined by ICD9 diagnosis codes...
July 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28487357/preventive-strategies-for-contrast-induced-acute-kidney-injury-and-the-winner-is%C3%A2
#8
EDITORIAL
Sripal Bangalore, Carlo Briguori
No abstract text is available yet for this article.
May 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28412390/first-generation-bioresorbable-vascular-scaffolds-disappearing-stents-or-disappearing-evidence
#9
EDITORIAL
Sripal Bangalore, Elazer R Edelman, Deepak L Bhatt
No abstract text is available yet for this article.
April 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28379800/body-weight-fluctuations-and-outcomes-in-coronary-disease
#10
RANDOMIZED CONTROLLED TRIAL
Sripal Bangalore, Rana Fayyad, Rachel Laskey, David A DeMicco, Franz H Messerli, David D Waters
BACKGROUND: Body-weight fluctuation is a risk factor for death and coronary events in patients without cardiovascular disease. It is not known whether variability in body weight affects outcomes in patients with coronary artery disease. METHODS: We determined intraindividual fluctuations in body weight from baseline weight and follow-up visits and performed a post hoc analysis of the Treating to New Targets trial, which involved assessment of the efficacy and safety of lowering low-density lipoprotein cholesterol levels with atorvastatin...
April 6, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28346238/management-of-hypertension-in-2017-targets-and-therapies
#11
Monica Ahluwalia, Sripal Bangalore
PURPOSE OF REVIEW: Approximately one-fourth of the adult population is diagnosed with hypertension, which has been associated with increased cardiovascular morbidity and mortality including cardiovascular death, myocardial infarction, heart failure and stroke. Early detection and treatment is key and can lead to a significant reduction in cardiovascular morbidity and mortality. RECENT FINDINGS: In this review, we discuss the management and treatment strategies in patients with hypertension in the current era...
July 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28303670/a-randomized-comparison-of-modified-subcutaneous-z-stitch-versus-manual-compression-to-achieve-hemostasis-after-large-caliber-femoral-venous-sheath-removal
#12
Radoslaw Pracon, Sripal Bangalore, Jan Henzel, Iwona Cendrowska-Demkow, Barbara Pregowska-Chwala, Agnieszka Tarnowska, Zofia Dzielinska, Zbigniew Chmielak, Adam Witkowski, Marcin Demkow
OBJECTIVES: To compare subcutaneous "Z"-stitch versus manual compression in attaining hemostasis after large bore femoral venous access, and to assess its impact on venous patency. BACKGROUND: Structural interventions increasingly require large caliber venous access, for which convenient, safe, and effective method of postprocedural hemostasis is needed. "Z"-stitch has been introduced for this purpose in some centers but systematic data on its performance is limited...
March 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28291624/corrigendum-to-contrast-media-use-in-patients-with-chronic-kidney-disease-undergoing-coronary-angiography-a-systematic-review-and-meta-analysis-of-randomized-trials-int-j-cardiol-2017-137-144
#13
Bhavi Pandya, Jean M Chalhoub, Valay Parikh, Sainath Gaddam, Jonathan Spagnola, Suzanne El-Sayegh, Marc Bogin, Ruben Kandov, James Lafferty, Sripal Bangalore
No abstract text is available yet for this article.
May 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28279314/meta-analysis-of-randomized-clinical-trials-comparing-biodegradable-polymer-drug-eluting-stent-to-second-generation-durable-polymer-drug-eluting-stents
#14
Georges El-Hayek, Sripal Bangalore, Abel Casso Dominguez, Chandan Devireddy, Wissam Jaber, Gautam Kumar, Kreton Mavromatis, Jacqueline Tamis-Holland, Habib Samady
OBJECTIVES: The authors sought to perform a meta-analysis of randomized clinical trials (RCTs) comparing the safety and efficacy of biodegradable polymer drug-eluting stents (BP-DES) to second-generation durable polymer drug-eluting stents (DP-DES). BACKGROUND: Prior meta-analyses have established the superiority of BP-DES over bare-metal stents and first-generation DP-DES; however, their advantage compared with second-generation DP-DES remains controversial. METHODS: The authors searched PubMed and Scopus databases for RCTs comparing BP-DES to the second-generation DP-DES...
March 13, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28244595/long-term-cardiovascular-mortality-after-radiotherapy-for-breast-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Partha Sardar, Amartya Kundu, Saurav Chatterjee, Anju Nohria, Ramez Nairooz, Sripal Bangalore, Debabrata Mukherjee, Wilbert S Aronow, Carl J Lavie
BACKGROUND: Radiotherapy (RT) is frequently associated with late cardiovascular (CV) complications. The mean cardiac dose from irradiation of a left-sided breast cancer is much higher than that for a right-sided breast cancer. However, data is limited on the long-term risks of RT on CV mortality. HYPOTHESIS: RT for breast cancer is associated with long term CV mortality and left sided RT carries a greater mortality than right sided RT. METHODS: We searched PubMed, Cochrane Central, Embase, EBSCO, Web of Science, and CINAHL databases from inception through December 2015...
February 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28185167/challenges-with-evidence-based-management-of-stable-ischemic-heart-disease
#16
REVIEW
Amit V Patel, Sripal Bangalore
PURPOSE OF REVIEW: Stable ischemic heart disease (SIHD) is a highly prevalent condition associated with increased costs, morbidity, and mortality. Management goals of SIHD can broadly be thought of in terms of improving prognosis and/or improving symptoms. Treatment options include medical therapy as well as revascularization, either with percutaneous coronary intervention or coronary artery bypass grafting. Herein, we will review the current evidence base for treatment of SIHD as well as its challenges and discuss ongoing studies to help address some of these knowledge gaps...
February 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28153104/outcomes-of-intensive-blood-pressure-lowering-in-older-hypertensive-patients
#17
REVIEW
Chirag Bavishi, Sripal Bangalore, Franz H Messerli
BACKGROUND: The 2014 Eighth Joint National Committee panel recommended a therapeutic target of systolic blood pressure (BP) <150 mm Hg in patients ≥60 years of age, a departure from prior recommendation of <140 mm Hg. OBJECTIVES: This study assessed the efficacy and safety of intensive BP-lowering strategies in older (age ≥65 years) hypertensive patients. METHODS: The MEDLINE, Scopus, EMBASE, and Cochrane databases were searched for all relevant randomized controlled trials from 1965 through July 1, 2016...
February 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28109971/optimal-systolic-blood-pressure-target-after-sprint-insights-from-a-network-meta-analysis-of-randomized-trials
#18
Sripal Bangalore, Bora Toklu, Eugenia Gianos, Arthur Schwartzbard, Howard Weintraub, Gbenga Ogedegbe, Franz H Messerli
BACKGROUND: The optimal on-treatment blood pressure (BP) target has been a matter of debate. The recent SPRINT trial showed significant benefits of a BP target of <120 mm Hg, albeit with an increase in serious adverse effects related to low BP. METHODS: PubMed, EMBASE, and CENTRAL were searched for randomized trials comparing treating with different BP targets. Trial arms were grouped into 5 systolic BP target categories: 1) <160 mm Hg, 2) <150 mm Hg, 3) <140 mm Hg, 4) <130 mm Hg, and 5) <120 mm Hg...
January 19, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28104622/renin-angiotensin-system-inhibitors-for-patients-with-stable-coronary-artery-disease-without-heart-failure-systematic-review-and-meta-analysis-of-randomized-trials
#19
REVIEW
Sripal Bangalore, Robert Fakheri, Simon Wandel, Bora Toklu, Jasmin Wandel, Franz H Messerli
OBJECTIVE:  To critically evaluate the efficacy of renin angiotensin system inhibitors (RASi) in patients with coronary artery disease without heart failure, compared with active controls or placebo. DESIGN:  Meta-analysis of randomized trials. DATA SOURCES:  PubMed, EMBASE, and CENTRAL databases until 1 May 2016. ELIGIBILITY CRITERIA FOR SELECTING STUDIES:  Randomized trials of RASi versus placebo or active controls in patients with stable coronary artery disease without heart failure (defined as left ventricular ejection fraction ≥40% or without clinical heart failure)...
January 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28077385/impact-of-sex-and-contact-to-device-time-on-clinical-outcomes-in-acute-st-segment-elevation-myocardial-infarction-findings-from-the-national-cardiovascular-data-registry
#20
Robert O Roswell, Jordan Kunkes, Anita Y Chen, Karen Chiswell, Sohah Iqbal, Matthew T Roe, Sripal Bangalore
BACKGROUND: Emergent myocardial reperfusion via primary percutaneous coronary intervention is optimal care for patients presenting with ST-segment elevation myocardial infarction (STEMI). Delays in such interventions are associated with increases in mortality. With the shift in focus to contact-to-device (C2D) time as a new perfusion metric, this study was designed to examine how sex affects C2D time and mortality in STEMI patients. METHODS AND RESULTS: Clinical data on male and female STEMI patients were extracted and analyzed from the National Cardiovascular Data Registry from July 1, 2008 to December 31, 2014...
January 11, 2017: Journal of the American Heart Association
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