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https://www.readbyqxmd.com/read/28185167/challenges-with-evidence-based-management-of-stable-ischemic-heart-disease
#1
REVIEW
Amit V Patel, Sripal Bangalore
PURPOSE OF REVIEW: Stable ischemic heart disease (SIHD) is a highly prevalent condition associated with increased costs, morbidity, and mortality. Management goals of SIHD can broadly be thought of in terms of improving prognosis and/or improving symptoms. Treatment options include medical therapy as well as revascularization, either with percutaneous coronary intervention or coronary artery bypass grafting. Herein, we will review the current evidence base for treatment of SIHD as well as its challenges and discuss ongoing studies to help address some of these knowledge gaps...
February 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28153104/outcomes-of-intensive-blood-pressure-lowering-in-older-hypertensive-patients
#2
Chirag Bavishi, Sripal Bangalore, Franz H Messerli
BACKGROUND: The 2014 Eighth Joint National Committee panel recommended a therapeutic target of systolic blood pressure (BP) <150 mm Hg in patients ≥60 years of age, a departure from prior recommendation of <140 mm Hg. OBJECTIVES: This study assessed the efficacy and safety of intensive BP-lowering strategies in older (age ≥65 years) hypertensive patients. METHODS: The MEDLINE, Scopus, EMBASE, and Cochrane databases were searched for all relevant randomized controlled trials from 1965 through July 1, 2016...
February 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28109971/optimal-systolic-blood-pressure-target-after-sprint-insights-from-a-network-meta-analysis-of-randomized-trials
#3
Sripal Bangalore, Bora Toklu, Eugenia Gianos, Arthur Schwartzbard, Howard Weintraub, Gbenga Ogedegbe, Franz H Messerli
BACKGROUND: The optimal blood pressure (BP) target has been a matter of debate. The recent SPRINT trial showed significant benefits of a BP target of <120 mm Hg albeit with an increase in serious adverse effects related to low BP. METHODS: PUBMED, EMBASE, and CENTRAL were searched for randomized trials comparing treating to different BP targets. Trial arms were grouped into five systolic BP target categories: 1) <160 mm Hg; 2) <150 mm Hg; 3) <140 mm Hg; 4) <130 mm Hg and 5) <120 mm Hg...
January 18, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28104622/renin-angiotensin-system-inhibitors-for-patients-with-stable-coronary-artery-disease-without-heart-failure-systematic-review-and-meta-analysis-of-randomized-trials
#4
Sripal Bangalore, Robert Fakheri, Simon Wandel, Bora Toklu, Jasmin Wandel, Franz H Messerli
OBJECTIVE:  To critically evaluate the efficacy of renin angiotensin system inhibitors (RASi) in patients with coronary artery disease without heart failure, compared with active controls or placebo. DESIGN:  Meta-analysis of randomized trials. DATA SOURCES:  PubMed, EMBASE, and CENTRAL databases until 1 May 2016. ELIGIBILITY CRITERIA FOR SELECTING STUDIES:  Randomized trials of RASi versus placebo or active controls in patients with stable coronary artery disease without heart failure (defined as left ventricular ejection fraction ≥40% or without clinical heart failure)...
January 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28077385/impact-of-sex-and-contact-to-device-time-on-clinical-outcomes-in-acute-st-segment-elevation-myocardial-infarction-findings-from-the-national-cardiovascular-data-registry
#5
Robert O Roswell, Jordan Kunkes, Anita Y Chen, Karen Chiswell, Sohah Iqbal, Matthew T Roe, Sripal Bangalore
BACKGROUND: Emergent myocardial reperfusion via primary percutaneous coronary intervention is optimal care for patients presenting with ST-segment elevation myocardial infarction (STEMI). Delays in such interventions are associated with increases in mortality. With the shift in focus to contact-to-device (C2D) time as a new perfusion metric, this study was designed to examine how sex affects C2D time and mortality in STEMI patients. METHODS AND RESULTS: Clinical data on male and female STEMI patients were extracted and analyzed from the National Cardiovascular Data Registry from July 1, 2008 to December 31, 2014...
January 11, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28066575/choosing-between-percutaneous-coronary-intervention-and-coronary-artery-bypass-graft-surgery-for-nondiabetic-patients-with-multivessel-disease
#6
EDITORIAL
Aeshita Dwivedi, Sripal Bangalore
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28040264/diagnosis-and-management-of-atherosclerotic-cardiovascular-disease-in-chronic-kidney-disease-a%C3%A2-review
#7
REVIEW
Roy O Mathew, Sripal Bangalore, Michael P Lavelle, Patricia A Pellikka, Mandeep S Sidhu, William E Boden, Arif Asif
Patients with chronic kidney disease (CKD) have a high prevalence of atherosclerotic cardiovascular disease, likely reflecting the presence of traditional risk factors. A greater distinguishing feature of atherosclerotic cardiovascular disease in CKD is the severity of the disease, which is reflective of an increase in inflammatory mediators and vascular calcification secondary to hyperparathyroidism of renal origin that are unique to patients with CKD. Additional components of atherosclerotic cardiovascular disease that are prominent in patients with CKD include microvascular disease and myocardial fibrosis...
December 28, 2016: Kidney International
https://www.readbyqxmd.com/read/28033306/outcomes-of-%C3%A2-6-month-versus-12-month-dual-antiplatelet-therapy-after-drug-eluting-stent-implantation-a-meta-analysis-and-meta-regression
#8
REVIEW
Pedro A Villablanca, Daniele Massera, Verghese Mathew, Sripal Bangalore, Panagiota Christia, Irving Perez, Ningxin Wan, Stefanie Schulz-Schüpke, David F Briceno, Anna E Bortnick, Mario J Garcia, Richard Lucariello, Mark Menegus, Robert Pyo, Jose Wiley, Harish Ramakrishna
BACKGROUND: The benefit of ≤6-month compared with 12-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) placement remains controversial. We performed a meta-analysis and meta-regression of ≤6-month versus 12-month DAPT in patients undergoing PCI with DES placement. METHODS: We conducted electronic database searches of randomized controlled trials (RCTs) comparing DAPT durations after DES placement...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28030663/perioperative-major-adverse-cardiovascular-and-cerebrovascular-events-associated-with-noncardiac-surgery
#9
Nathaniel R Smilowitz, Navdeep Gupta, Harish Ramakrishna, Yu Guo, Jeffrey S Berger, Sripal Bangalore
Importance: Major adverse cardiovascular and cerebrovascular events (MACCE) are a significant source of perioperative morbidity and mortality following noncardiac surgery. Objective: To evaluate national trends in perioperative cardiovascular outcomes and mortality after major noncardiac surgery and to identify surgical subtypes associated with cardiovascular events using a large administrative database of United States hospital admissions. Design, Setting, Participants: Patients who underwent major noncardiac surgery from January 2004 to December 2013 were identified using the National Inpatient Sample...
February 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/27984005/treatment-resistant-hypertension-and-outcomes-based-on-randomized-treatment-group-in-allhat
#10
Sripal Bangalore, Barry R Davis, William C Cushman, Sara L Pressel, Paul M Muntner, David A Calhoun, John B Kostis, Paul K Whelton, Jeffrey L Probstfield, Mahboob Rahman, Henry R Black
BACKGROUND: Although hypertension guidelines define treatment-resistant hypertension as blood pressure uncontrolled by ≥3 antihypertensive medications, including a diuretic, it is unknown whether patient prognosis differs when a diuretic is included. METHODS: Participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) were randomly assigned to first-step therapy with chlorthalidone, amlodipine, or lisinopril. At a Year 2 follow-up visit, those with average blood pressure ≥140 mm Hg systolic or ≥90 mm Hg diastolic on ≥3 antihypertensive medications, or blood pressure <140/90 mm Hg on ≥4 antihypertensive medications were identified as having apparent treatment-resistant hypertension...
October 27, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27978963/introduction-controversies-in-hypertension
#11
EDITORIAL
Franz H Messerli, Sripal Bangalore
No abstract text is available yet for this article.
November 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/27970154/tct-767-effect-of-renal-artery-denervation-on-heart-rate-insights-from-a-systematic-review-and-meta-analysis
#12
Bora Toklu, Franz H Messerli, Stefano F Rimoldi, Sripal Bangalore
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970060/tct-683-a-meta-analysis-and-meta-regression-of-long-term-outcomes-of-transcatheter-versus-surgical-aortic-valve-replacement-for-severe-aortic%C3%A2-stenosis
#13
Pedro Villablanca, Mohammed Makkiya, Verghese Mathew, Vinod Thourani, Josep Rodés-Cabau, Sripal Bangalore, Peter Vlismas, David Briceno, David Slovut, Cynthia Taub, Patrick McCarthy, John Augoustides, Harish Ramakrishna
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969813/tct-457-paclitaxel-eluting-stents-vs-everolimus-eluting-coronary-stents-in-a-diabetic-population-2-years-follow-up-of-tuxedo-india-trial
#14
Upendra Kaul, Dr Rajpal K Abhaichand, Tejas Patel, Darshan Banker, Atul Abhyankar, Ajit Mullasari, Sanjay Shah, Rajneesh Jain, Premchand Rajendra Kumar, C G Bahuleyan, Priyadarshini Arambam, Sripal Bangalore
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969806/tct-450-bare-metal-stent-durable-polymer-drug-eluting-stent-or-biodegradable-polymer-drug-eluting-stent-in-patients-with-diabetes-mellitus-a-mixed-treatment-comparison-analysis-of-63-940-patient-years-of-follow-up-from-randomized-trials
#15
Bora Toklu, Sripal Bangalore, Upendra Kaul, Michael Attubato, Frederick Feit, Deepak Bhatt
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27939230/relation-of-variability-of-low-density-lipoprotein-cholesterol-and-blood-pressure-to-events-in-patients-with-previous-myocardial-infarction-from-the-ideal-trial
#16
Sripal Bangalore, Rana Fayyad, Franz H Messerli, Rachel Laskey, David A DeMicco, John J P Kastelein, David D Waters
In patients with previous myocardial infarction (MI), aggressive hypertension control and low-density lipoprotein cholesterol (LDL-C) reduction are important secondary prevention measures. However, residual risk remains despite aggressive treatment. Whether variability in blood pressure (BP) and LDL-C can explain this residual risk is not known. Patients enrolled in the Incremental Decrease in End Points Through Aggressive Lipid-Lowering trial with at least 1 post-baseline measurement of LDL-C and blood pressure (BP) were included...
February 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27884647/salt-tomato-soup-and-hypocrisy-of-the-american-heart-association
#17
EDITORIAL
Franz H Messerli, Stefano F Rimoldi, Sripal Bangalore
No abstract text is available yet for this article.
November 21, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27863354/contrast-media-use-in-patients-with-chronic-kidney-disease-undergoing-coronary-angiography-a-systematic-review-and-meta-analysis-of-randomized-trials
#18
Bhavi Pandya, Jean Chaloub, Valay Parikh, Sainath Gaddam, Jonathan Spagnola, Suzanne El-Sayegh, Marc Bogin, Ruben Kandov, James Lafferty, Sripal Bangalore
BACKGROUND: Patients with chronic kidney disease (CKD) undergoing coronary angiography (CA), adequate hydration and minimizing volume of contrast media (CM) are class 1b recommendations for preventing contrast induced nephropathy (CIN). Current data are insufficient to justify specific recommendations about isoosmolar vs. low-osmolar contrast media by the ACCF/AHA/SCAI guidelines. METHODS: Randomized trials comparing IOCM to LOCM in CKD stage 3 and above patients undergoing CA, and reporting incidence of CIN (defined by a rise in creatinine of 25% from baseline) were included in the analysis...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27846456/management-and-outcomes-of-acute-myocardial-infarction-in-patients-with-chronic-kidney-disease
#19
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Rina Mauricio, Sripal Bangalore
BACKGROUND: Chronic kidney disease (CKD) is associated with cardiovascular disease and acute myocardial infarction (AMI). Contemporary management and outcomes of AMI in patients with CKD have not been reported. METHODS: We analyzed United States National Inpatient Sample data for patients admitted with AMI with or without CKD from 2007 to 2012. Propensity score matching was used to identify patients with AMI and CKD with similar baseline characteristics who were managed invasively (cardiac catheterization, percutaneous coronary intervention [PCI], or coronary artery bypass graft surgery [CABG]) or conservatively...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27796850/cardiovascular-risk-stratification-after-renal-transplant-is-spect-mpi-the-answer
#20
EDITORIAL
Karen Kan, Sripal Bangalore
No abstract text is available yet for this article.
October 28, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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