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https://www.readbyqxmd.com/read/29778671/international-study-of-comparative-health-effectiveness-with-medical-and-invasive-approaches-ischemia-trial-rationale-and-design
#1
David J Maron, Judith S Hochman, Sean M O'Brien, Harmony R Reynolds, William E Boden, Gregg W Stone, Sripal Bangalore, John A Spertus, Daniel B Mark, Karen P Alexander, Leslee Shaw, Jeffrey S Berger, T Bruce Ferguson, David O Williams, Robert A Harrington, Yves Rosenberg
BACKGROUND: Prior trials comparing a strategy of optimal medical therapy with or without revascularization have not shown that revascularization reduces cardiovascular events in patients with stable ischemic heart disease (SIHD). However, those trials only included participants in whom coronary anatomy was known prior to randomization and did not include sufficient numbers of participants with significant ischemia. It remains unknown whether a routine invasive approach offers incremental value over a conservative approach with catheterization reserved for failure of medical therapy in patients with moderate or severe ischemia...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29752391/ischemia-establishing-the-primary-end-point
#2
Sripal Bangalore, David J Maron, Harmony R Reynolds, Gregg W Stone, Sean M O'Brien, Karen P Alexander, Judith S Hochman
No abstract text is available yet for this article.
May 2018: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29731024/the-potential-effects-of-new-stent-platforms-for-coronary-revascularization-in-patients-with-diabetes
#3
REVIEW
Gustavo S Guandalini, Sripal Bangalore
Coronary artery disease in patients with diabetes mellitus (DM) is characterized by extensive atherosclerosis, longer lesions, and diffuse distal disease. Consequently, these patients have worse outcomes after coronary revascularization, regardless of the modality used. Traditionally, coronary artery bypass grafting (CABG) has been regarded as more effective than percutaneous coronary intervention (PCI) in patients with DM, likely because of more complete revascularization and protection against disease progression in the bypass segment...
May 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29701805/cardiac-rehabilitation-fitness-changes-and-subsequent-survival
#4
Alban De Schutter, Sergey Kachur, Carl J Lavie, Arthur Menezes, Kelly K Shum, Sripal Bangalore, Ross Arena, Richard V Milani
Aims: Assessments of cardiac rehabilitation (CR) in coronary heart disease (CHD) cohorts usually examine mortality in aggregate. The current study examines the prognosis and characteristics of patients who enrolled and completed CR, stratified by their level of improvement in cardiorespiratory fitness (CRF) by examining the characteristics, outcomes and predictors of non-response in CRF (NonRes) compared to low-responders (LowRes) and high-Responders (HighRes) after CR. Methods And Results: 1171 CHD patients were referred for a phase II CR program after therapy for an acute coronary syndrome, coronary artery bypass graft procedure or a percutaneous coronary intervention between January 1, 2000 and June 30, 2013 underwent cardiopulmonary exercise testing before and after CR...
April 26, 2018: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29600024/does-validate-swedeheart-invalidate-the-use-of-bivalirudin-in-myocardial-infarction
#5
EDITORIAL
Caroline Ong, Sripal Bangalore
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29598869/angiotensin-converting-enzyme-inhibitors-in-hypertension-to-use-or-not-to-use
#6
REVIEW
Franz H Messerli, Sripal Bangalore, Chirag Bavishi, Stefano F Rimoldi
Most guidelines for the management of patients with cardiovascular disease recommend angiotensin-converting enzyme (ACE) inhibitors as first-choice therapy, whereas angiotensin receptor blockers (ARBs) are merely considered an alternative for ACE inhibitor-intolerant patients. The aim of this review was to compare outcomes and adverse events between ACE inhibitors and ARBs in patients. In patients with hypertension and hypertension with compelling indications, we found no difference in efficacy between ARBs and ACE inhibitors with regard to the surrogate endpoint of blood pressure and outcomes of all-cause mortality, cardiovascular mortality, myocardial infarction, heart failure, stroke, and end-stage renal disease...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29571453/increasing-inclusion-of-patients-with-advanced-chronic-kidney-disease-in-cardiovascular-clinical-trials
#7
Roy O Mathew, Sripal Bangalore, Mandeep S Sidhu, Jerome L Fleg, Franklin W Maddux
No abstract text is available yet for this article.
April 2018: Kidney International
https://www.readbyqxmd.com/read/29545007/what-ever-happened-to-cardioprotection-with-%C3%AE-blockers
#8
EDITORIAL
Franz H Messerli, Thomas Suter, Sripal Bangalore
No abstract text is available yet for this article.
March 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29463510/device-thrombosis-after-percutaneous-left-atrial-appendage-occlusion-is-related-to-patient-and-procedural-characteristics-but-not-to-duration-of-postimplantation-dual-antiplatelet-therapy
#9
Radoslaw Pracon, Sripal Bangalore, Zofia Dzielinska, Marek Konka, Cezary Kepka, Mariusz Kruk, Edyta Kaczmarska-Dyrda, Joanna Petryka-Mazurkiewicz, Sebastian Bujak, Mateusz Solecki, Agnieszka Pskit, Agnieszka Dabrowska, Bartosz Sieradzki, Andrzej Plonski, Witold Ruzyllo, Adam Witkowski, Marcin Demkow
BACKGROUND: Device-related thrombus (DRT) after left atrial appendage occlusion is a worrisome finding with little knowledge about when to expect it and how to prevent it. This study sought to investigate correlates of DRT after left atrial appendage occlusion, its time of diagnosis, and particularly, association with postimplantation dual antiplatelet therapy duration. METHODS AND RESULTS: Consecutive patients (n=102) after left atrial appendage occlusion with AMPLATZER Cardiac Plug/Amulet (n=59) or WATCHMAN (n=43) were included in a prospective registry (October 2011-May 2016)...
March 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29325633/lowering-the-thresholds-of-diseases-is-anyone-still-healthy
#10
EDITORIAL
Franz H Messerli, Sripal Bangalore
No abstract text is available yet for this article.
January 16, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29324999/changing-definition-of-hypertension-in-guidelines-how-innocent-a-number-game
#11
Franz H Messerli, Stefano F Rimoldi, Sripal Bangalore
No abstract text is available yet for this article.
January 9, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29310989/visit-to-visit-variability-of-lipid-measurements-as-predictors-of-cardiovascular-events
#12
David D Waters, Sripal Bangalore, Rana Fayyad, David A DeMicco, Rachel Laskey, Shari Melamed, Philip J Barter
BACKGROUND: Higher visit-to-visit variability in risk factors such as blood pressure and low-density lipoprotein (LDL)-cholesterol are associated with an increase in cardiovascular (CV) events. OBJECTIVE: The purpose of this study was to determine whether variability in high-density lipoprotein cholesterol (HDL-C) and triglyceride levels predicted coronary and CV events in a clinical trial population with known coronary disease. METHODS: We assessed intraindividual variability in fasting high-density lipoprotein (HDL)-cholesterol, triglyceride, and LDL-cholesterol measurements among 9572 patients in the Treating to New Targets trial and correlated the results with coronary events over a median follow-up of 4...
March 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29306484/meta-analysis-comparing-patent-foramen-ovale-closure-versus-medical-therapy-to-prevent-recurrent-cryptogenic-stroke
#13
Tomo Ando, Anthony A Holmes, Mohit Pahuja, Arshad Javed, Alenxandros Briasoulis, Tesfaye Telila, Hisato Takagi, Theodore Schreiber, Luis Afonso, Cindy L Grines, Sripal Bangalore
New evidence suggests that closure of a patent foramen ovale (PFO) plus medical therapy (MT; antiplatelet or anticoagulation) is superior to MT alone to prevent recurrent cryptogenic stroke. We performed a meta-analysis of randomized controlled trials that compared PFO closure plus MT with MT alone in patients with cryptogenic stroke. The efficacy end points were recurrent stroke, transient ischemia attack, and death. The safety end points were major bleeding and newly detected atrial fibrillation. Trials were pooled using random effects and fixed effects models...
March 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29305561/trends-in-cardiovascular-risk-factor-and-disease-prevalence-in-patients-undergoing-non-cardiac-surgery
#14
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Joshua A Beckman, Sripal Bangalore, Jeffrey S Berger
OBJECTIVES: Cardiovascular risk factors are prevalent in the population undergoing non-cardiac surgery. Changes in perioperative cardiovascular risk factor profiles over time are unknown. The objective of this study was to evaluate national trends in cardiovascular risk factors and atherosclerotic cardiovascular disease (ASCVD) among patients undergoing non-cardiac surgery. METHODS: Adults aged ≥45 years old who underwent non-cardiac surgery were identified using the US National Inpatient Sample from 2004 to 2013...
January 5, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29304995/meta-analysis-of-culprit-only-versus-multivessel-percutaneous-coronary-intervention-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-coronary-disease
#15
Sripal Bangalore, Bora Toklu, Gregg W Stone
Recently, several randomized controlled trials (RCT) in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD) have compared a strategy of routine multivessel percutaneous coronary intervention (PCI) performed either as a single procedure or as staged procedures to culprit-only PCI. All of these trials have been underpowered for clinical end points. We searched PubMed, Embase, and Cochrane Central Register of Controlled Trials for RCT comparing multivessel PCI with culprit-only PCI in patients with STEMI and MVD...
March 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29241488/do-we-need-a-trial-of-des-versus-cabg-surgery-in-diabetic-patients-with-acs
#16
EDITORIAL
Sripal Bangalore, Deepak L Bhatt
No abstract text is available yet for this article.
December 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29216997/the-state-of-the-absorb-bioresorbable-scaffold-consensus-from-an-expert-panel
#17
REVIEW
Sripal Bangalore, Hiram G Bezerra, David G Rizik, Ehrin J Armstrong, Bruce Samuels, Srihari S Naidu, Cindy L Grines, Malcolm T Foster, James W Choi, Barry D Bertolet, Atman P Shah, Rebecca Torguson, Surendra B Avula, John C Wang, James P Zidar, Aziz Maksoud, Arun Kalyanasundaram, Steven J Yakubov, Bassem M Chehab, Anthony J Spaedy, Srini P Potluri, Ronald P Caputo, Ashok Kondur, Robert F Merritt, Amir Kaki, Ramon Quesada, Manish A Parikh, Catalin Toma, Fadi Matar, Joseph DeGregorio, William Nicholson, Wayne Batchelor, Raghava Gollapudi, Ethan Korngold, Riyaz Sumar, George S Chrysant, Jun Li, John B Gordon, Rajesh M Dave, Guilherme F Attizzani, Tom P Stys, Osvaldo S Gigliotti, Bruce E Murphy, Stephen G Ellis, Ron Waksman
Significant progress has been made in the percutaneous coronary intervention technique from the days of balloon angioplasty to modern-day metallic drug-eluting stents (DES). Although metallic stents solve a temporary problem of acute recoil following balloon angioplasty, they leave behind a permanent problem implicated in very late events (in addition to neoatherosclerosis). BRS were developed as a potential solution to this permanent problem, but the promise of these devices has been tempered by clinical trials showing increased risk of safety outcomes, both early and late...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29140424/cholesterol-variability-a-marker-for-increased-risk-or-a-risk-factor
#18
Sripal Bangalore
No abstract text is available yet for this article.
December 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29129003/chelation-therapy-as-a-cardiovascular-therapeutic-strategy-the-rationale-and-the-data-in-review
#19
REVIEW
Roy O Mathew, Joshua Schulman-Marcus, Elizabeth L Nichols, Jonathan D Newman, Sripal Bangalore, Michael Farkouh, Mandeep S Sidhu
Chelation therapy, typically used to remove heavy metal toxins, has also been controversially used as a treatment for coronary artery disease. The first Trial to Assess Chelation Therapy (TACT) aimed to provide evidence on chelation therapy's potential for benefit or harm. Although TACT had some significant results, the trial does not provide enough evidence to recommend routine chelation therapy and has limitations. The second TACT was recently funded reigniting a discussion about the value of chelation therapy, its efficacy, and allocation of research resources...
December 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29117465/more-sprint-controversy
#20
F H Messerli, S Bangalore, S F Rimoldi
No abstract text is available yet for this article.
March 2018: Journal of Internal Medicine
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