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Rohit arora

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https://www.readbyqxmd.com/read/28043503/isoniazid-resistance-among-rifampicin-susceptible-mycobacterium-tuberculosis-isolates-from-tuberculosis-patients
#1
Jyoti Arora, Ritu Singhal, Ajoy Kumar Verma, Gavish Kumar, Manpreet Bhalla, Rohit Sarin, Vithal Prasad Myneedu
OBJECTIVE/BACKGROUND: With the introduction of novel molecular techniques that rely on rifampicin (RIF) susceptibility, resistance to isoniazid (INH) or other first-line drugs remains undetected. Such patients are prescribed first-line antituberculosis therapy and are on RIF monodrug therapy during the continuation phase, which may lead to therapeutic failure and emergence of multidrug resistance. We aimed to study INH resistance among RIF-susceptible Mycobacterium tuberculosis (MTB) isolates from retreatment patients...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28024556/current-and-future-status-of-extracorporeal-cardiopulmonary-resuscitation-for-in-hospital-cardiac-arrest
#2
REVIEW
Rohit K Singal, Deepa Singal, Joseph Bednarczyk, Yoan Lamarche, Gurmeet Singh, Vivek Rao, Hussein D Kanji, Rakesh C Arora, Rizwan A Manji, Eddy Fan, A Dave Nagpal
Numerous series, propensity-matched trials, and meta-analyses suggest that appropriate use of extracorporeal cardiopulmonary resuscitation (E-CPR) for in-hospital cardiac arrest (IHCA) can be lifesaving. Even with an antecedent cardiopulmonary resuscitation (CPR) duration in excess of 45 minutes, 30-day survival with favourable neurologic outcome using E-CPR is approximately 35%-45%. Survival may be related to age, duration of CPR, or etiology. Associated complications include sepsis, renal failure, limb and neurologic complications, hemorrhage, and thrombosis...
January 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28024549/temporary-mechanical-circulatory-support-in-cardiac-critical-care-a-state-of-the-art-review-and-algorithm-for-device-selection
#3
REVIEW
A Dave Nagpal, Rohit K Singal, Rakesh C Arora, Yoan Lamarche
With more than 60 years of continuous development and improvement, a variety of temporary mechanical circulatory support (MCS) devices and implantation strategies exist, each with unique advantages and disadvantages. A thorough understanding of each available device is essential for optimizing patient outcomes in a fiscally responsible manner. In this state of the art review we examine the entire range of commonly available peripheral and centrally cannulated temporary MCS devices, including intra-aortic balloon pumps, the Impella (Abiomed, Danvers, MA) family of microaxial pumps, the TandemHeart (CardiacAssist Inc, Pittsburg, PA) pump and percutaneous cannulas, centrally cannulated centrifugal pumps such as the CentriMag (Thoratec Corp, Pleasanton, CA/St Jude Medical, St Paul, MN/Abbott Laboratories, Abbott Park, IL) and Rotaflow (Maquet Holding BV & Co KG, Rastatt Germany), and extracorporeal membrane oxygenation...
January 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27987225/arrhythmias-in-adults-with-congenital-heart-disease-what-are-risk-factors-for-specific-arrhythmias
#4
Rohit S Loomba, Matthew W Buelow, Saurabh Aggarwal, Rohit R Arora, Joshua Kovach, Salil Ginde
INTRODUCTION: An increasing number of patients with congenital heart disease are now surviving into adulthood. This has also led to the emergence of complications from the underlying congenital heart disease, related surgical interventions, and associated combordities. While the prevalence of particular arrhythmias with specific congenital heart disease has been previously described, a detailed analysis of all lesions and a large number of comorbidities has not been previously published...
December 16, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27864303/diagnosis-of-left-ventricular-assist-device-outflow-graft-obstruction-using-intravascular-ultrasound
#5
Hellmuth R Muller Moran, Malek Kass, Amir Ravandi, Shelley Zieroth, S Allan Schaffer, Francisco J Cordova, Zlatko I Pozeg, Rakesh C Arora, Rohit K Singal
No abstract text is available yet for this article.
December 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27817949/extracorporeal-membrane-oxygenation-postcardiotomy-with-great-power-comes-great-responsibility
#6
EDITORIAL
Rakesh C Arora, Paul E Wischmeyer, Rohit K Singal
No abstract text is available yet for this article.
January 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27777449/3-butenyl-isothiocyanate-a-hydrolytic-product-of-glucosinolate-as-a-potential-cytotoxic-agent-against-human-cancer-cell-lines
#7
Rohit Arora, Rakesh Kumar, Jyoti Mahajan, Adarsh P Vig, Bikram Singh, Balbir Singh, Saroj Arora
The present study envisages the cytotoxic potential of 3-butenyl isothiocyanate isolated from Brassica juncea L. Czern var. Pusa Jaikisan against the human cancer cell lines viz. prostate, bone osteosarcoma, cervical, liver, neuroblastoma and breast cancer. As the compound was observed to be more effective against prostate cancer cell line, therefore, this cell line was further used to study the mechanism of cell death using neutral red assay, reactive oxygen species assay, mitochondrial membrane potential assay, microscopic and cell cycle analysis...
September 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27625444/comparative-study-of-clinico-bacterio-radiological-profile-and-treatment-outcome-of-smokers-and-nonsmokers-suffering-from-pulmonary-tuberculosis
#8
Deepti Rathee, Piyush Arora, Manoj Meena, Rohit Sarin, Pitambar Chakraborty, Anand Jaiswal, Mukesh Goyal
INTRODUCTION: Tuberculosis (TB) is one of the leading causes of death and disease worldwide. Tobacco smoking has been linked as a risk factor for TB. This study was aimed to affirm the strength of association between smoking and pulmonary TB. MATERIALS AND METHODS: Pulmonary TB patients aged between 18 and 65 years were enrolled and followed-up until treatment completion. Two consecutive sputum smears were examined from each patient for the presence of acid-fast bacilli (AFB) using Ziehl-Neelsen technique...
September 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27617618/dominant-versus-nondominant-hand-cardiopulmonary-resuscitation-is-there-really-true-dominance
#9
Rohit S Loomba, Karan Nijhawan, Saurabh Aggarwal, Rohit R Arora
No abstract text is available yet for this article.
September 9, 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/27512081/cholesteryl-ester-transfer-protein-inhibitors-trials-and-tribulations
#10
Julian Hardy McLain, Andrew Jacob Alsterda, Rohit R Arora
The cholesteryl ester transfer protein (CETP) is a plasma protein that plays an important role in the transfer of lipids between plasma lipoproteins. The CETP inhibitors have been widely studied as a pharmacologic therapy to target plasma cholesterol in order to reduce the risk of atherosclerotic cardiovascular disease . Using CETP inhibitors as cholesterol modifiers was based on the genetic research that found correlations between CETP activity and cholesterol levels. Although CETP inhibitors are successful at altering targeted cholesterol markers, recent phase 3 outcome trials have shown limited benefit on cardiovascular outcomes when combined with the current standard of care...
August 10, 2016: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27455969/chemical-crosslinking-role-in-protein-and-peptide-science
#11
Bharti Arora, Rashmi Tandon, Pankaj Attri, Rohit Bhatia
BACKGROUND: Chemical crosslinking refers to intermolecular or intramolecular joining of two or more molecules by a covalent bond. The reagents that are used for the purpose are referred to as 'crosslinking reagents' or 'crosslinkers'. Based on factors like reactivity and spacer length these are classified into different types, each having its own specific function and application. In recent times, chemical crosslinking has emerged as an efficient tool for the study of biomolecules like proteins...
July 24, 2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/27415977/therapeutic-modulation-of-aortic-stiffness
#12
Ahmed Muzhir Hussein, Ghazwan Shaaya, Rohit Arora, Ali Al-Khazaali, Khalid Al-Khafaji, Hanan K Helu
Aortic stiffness (AS) is an important predictor of cardiovascular morbidity in humans. The present review discusses the possible pathophysiological mechanisms of AS and focuses on a survey of different therapeutic modalities for decreasing AS. The influence of several nonpharmacological interventions is described: decrease body weight, diet, aerobic exercise training, music, and continuous positive airway pressure therapy. The effects of different pharmacological drug classes on AS are also discussed: antihypertensive drugs-renin-angiotensin-aldosterone system drugs, beta-blockers, alpha-blockers, diuretics, and calcium channel blockers (CCBs)-advanced glycation end product cross-link breakers, statins, oral anti-diabetics, anti-inflammatory drugs, vitamin D, antioxidant vitamins, and endothelin-1 receptor antagonists...
November 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/27386374/effect-of-cobalt-ii-chloride-hexahydrate-on-some-human-cancer-cell-lines
#13
Sonia Mahey, Rakesh Kumar, Rohit Arora, Jyoti Mahajan, Saroj Arora, Renu Bhardwaj, Ashwani Kumar Thukral
The present study investigates the anti-proliferative and apoptosis inducing mechanism of CoCl2·6H2O in PC-3 cancer cell line. Preliminary, three different forms of cobalt i.e., cobaltous (CoCl2·6H2O), macro-Co(II,III) oxide and nano-Co(II,III) oxide were screened for antiproliferative activity in PC-3 cell line. The CoCl2·6H2O being the most effective antiproliferative agent, hence it was further tested against lung (A549), prostrate (PC-3) and brain (IMR-32) cell lines. Human embryonic kidney cell line (293T) was used as a normal cell line to compare the toxicity of CoCl2·6H2O...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27385554/correction-to-structural-investigation-of-b-raf-paradox-breaker-and-inducer-inhibitors
#14
Rohit Arora, Michela Di Michele, Elisabeth Stes, Elien Vandermarliere, Lennart Martens, Kris Gevaert, Erika Van Heerde, Joannes T M Linders, Dirk Brehmer, Edgar Jacoby, Pascal Bonnet
No abstract text is available yet for this article.
July 28, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27335153/sequence-analysis-of-fluoroquinolone-resistance-associated-genes-gyra-and-gyrb-in-clinical-mycobacterium-tuberculosis-isolates-from-patients-suspected-of-having-multidrug-resistant-tuberculosis-in-new-delhi-india
#15
Ritu Singhal, Paul R Reynolds, Jamie L Marola, L Elaine Epperson, Jyoti Arora, Rohit Sarin, Vithal Prasad Myneedu, Michael Strong, Max Salfinger
Fluoroquinolones (FQs) are broad-spectrum antibiotics recommended for the treatment of multidrug-resistant tuberculosis (MDR-TB) patients. FQ resistance, caused by mutations in the gyrA and gyrB genes of Mycobacterium tuberculosis, is increasingly reported worldwide; however, information on mutations occurring in strains from the Indian subcontinent is scarce. Hence, in this study, we aimed to characterize mutations in the gyrA and gyrB genes of acid-fast bacillus (AFB) smear-positive sediments or of M. tuberculosis isolates from AFB smear-negative samples from patients in India suspected of having MDR-TB...
September 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27217994/conventional-and-modified-hydrodistillation-method-for-the-extraction-of-glucosinolate-hydrolytic-products-a-comparative-account
#16
Rohit Arora, Bikram Singh, Adarsh Pal Vig, Saroj Arora
Eruca sativa is extensively used as raw and its oil is also used for cooking due to its exceptional flavour. The volatile nature of the hydrolytic products of glucosinolates makes the extraction difficult. The hydrodistillation method used previously yield very less amount of the extract as well as the absence of stirring in the round bottom flask causes burning of both the crushed seeds and the flask. To overcome these drawbacks, a method has been developed using magnetic stirrer and hot plate. The yield and composition of hydrolytic products in the extract with the modified method was increased along with an increase in the amount of major hydrolytic products as seen by GC-MS...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27099428/effect-of-phytic-acid-ethylenediaminetetraacetic-acid-and-chitosan-solutions-on-microhardness-of-the-human-radicular-dentin
#17
Vineeta Nikhil, Shikha Jaiswal, Parul Bansal, Rohit Arora, Shalya Raj, Pulkit Malhotra
AIM: The purpose of this study was to evaluate the effect of phytic acid, ethylenediaminetetraacetic acid (EDTA), and chitosan solutions on the microhardness of human radicular dentin. MATERIALS AND METHODS: Thirty dentin specimens were randomly divided into three groups of 10 specimens each according to the irrigant used: G1 - 1% phytic acid, G2 - 17% EDTA, and G3 - 0.2% chitosan. A standardized volume of each chelating solution was used for 3 min. Dentin microhardness was measured before and after application at the cervical, middle, and apical levels with a Vickers indenter under a 200-g load and a 10-s dwell time...
March 2016: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/27087163/to-analyze-the-amelioration-of-phenobarbital-induced-oxidative-stress-by-erucin-as-indicated-by-biochemical-and-histological-alterations
#18
Rohit Arora, Sakshi Bhushan, Rakesh Kumar, Rahul Mannan, Pardeep Kaur, Bikram Singh, Ritika Sharma, Adarsh Pal Vig, Balbir Singh, Amrit Pal Singh, Saroj Arora
PURPOSE: Phenobarbital is a commonly employed antidepressant and anti-epileptic drug. The cancer promoting activity of this genotoxic xenobiotic is often ignored. It is responsible for oxidative stress leading to modulation in xenobiotic and antioxidative enzymes. Glucosinolates and more specifically their hydrolytic products are known for their antioxidative and anticancer activities. The present study involves the analysis of hepatoprotective effect of erucin (isolated from Eruca sativa (Mill...
2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27054816/advanced-molecular-dynamics-simulation-methods-for-kinase-drug-discovery
#19
Samia Aci-Sèche, Sonia Ziada, Abdennour Braka, Rohit Arora, Pascal Bonnet
Interest in the application of molecular dynamics (MD) simulations has increased in the field of protein kinase (PK) drug discovery. PKs belong to an important drug target class because they are directly involved in a number of diseases, including cancer. MD methods simulate dynamic biological and chemical events at an atomic level. This information can be combined with other in silico and experimental methods to efficiently target selected receptors. In this review, we present common and advanced methods of MD simulations and we focus on the recent applications of MD-based methodologies that provided significant insights into the elucidation of biological mechanisms involving PKs and into the discovery of novel kinase inhibitors...
April 2016: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/27012455/neutrophil-gelatinase-associated-lipocalin-to-predict-cardiac-surgery-associated-acute-kidney-injury-a-holy-grail-or-just-another%C3%A2-fancy-cup
#20
EDITORIAL
Rakesh C Arora, Claudio Rigatto, Rohit K Singal
No abstract text is available yet for this article.
June 2016: Journal of Thoracic and Cardiovascular Surgery
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