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Rohit arora

Hellmuth R Muller Moran, Malek Kass, Amir Ravandi, Shelley Zieroth, S Allan Schaffer, Francisco J Cordova, Zlatko I Pozeg, Rakesh C Arora, Rohit K Singal
No abstract text is available yet for this article.
December 2016: Circulation. Heart Failure
Rakesh C Arora, Paul E Wischmeyer, Rohit K Singal
No abstract text is available yet for this article.
October 24, 2016: Journal of Thoracic and Cardiovascular Surgery
Rohit Arora, Rakesh Kumar, Jyoti Mahajan, Adarsh P Vig, Bikram Singh, Balbir Singh, Saroj Arora
The present study envisages the cytotoxic potential of 3-butenyl isothiocyanate isolated from Brassica juncea L. Czern var. Pusa Jaikisan against the human cancer cell lines viz. prostate, bone osteosarcoma, cervical, liver, neuroblastoma and breast cancer. As the compound was observed to be more effective against prostate cancer cell line, therefore, this cell line was further used to study the mechanism of cell death using neutral red assay, reactive oxygen species assay, mitochondrial membrane potential assay, microscopic and cell cycle analysis...
September 2016: Journal of Food Science and Technology
Deepti Rathee, Piyush Arora, Manoj Meena, Rohit Sarin, Pitambar Chakraborty, Anand Jaiswal, Mukesh Goyal
INTRODUCTION: Tuberculosis (TB) is one of the leading causes of death and disease worldwide. Tobacco smoking has been linked as a risk factor for TB. This study was aimed to affirm the strength of association between smoking and pulmonary TB. MATERIALS AND METHODS: Pulmonary TB patients aged between 18 and 65 years were enrolled and followed-up until treatment completion. Two consecutive sputum smears were examined from each patient for the presence of acid-fast bacilli (AFB) using Ziehl-Neelsen technique...
September 2016: Lung India: Official Organ of Indian Chest Society
Rohit S Loomba, Karan Nijhawan, Saurabh Aggarwal, Rohit R Arora
No abstract text is available yet for this article.
September 9, 2016: American Journal of Therapeutics
Julian Hardy McLain, Andrew Jacob Alsterda, Rohit R Arora
The cholesteryl ester transfer protein (CETP) is a plasma protein that plays an important role in the transfer of lipids between plasma lipoproteins. The CETP inhibitors have been widely studied as a pharmacologic therapy to target plasma cholesterol in order to reduce the risk of atherosclerotic cardiovascular disease . Using CETP inhibitors as cholesterol modifiers was based on the genetic research that found correlations between CETP activity and cholesterol levels. Although CETP inhibitors are successful at altering targeted cholesterol markers, recent phase 3 outcome trials have shown limited benefit on cardiovascular outcomes when combined with the current standard of care...
August 10, 2016: Journal of Cardiovascular Pharmacology and Therapeutics
Bharti Arora, Rashmi Tandon, Pankaj Attri, Rohit Bhatia
BACKGROUND: Chemical crosslinking refers to intermolecular or intramolecular joining of two or more molecules by a covalent bond. The reagents that are used for the purpose are referred to as 'crosslinking reagents' or 'crosslinkers'. Based on factors like reactivity and spacer length these are classified into different types, each having its own specific function and application. In recent times, chemical crosslinking has emerged as an efficient tool for the study of biomolecules like proteins...
July 24, 2016: Current Protein & Peptide Science
Ahmed Muzhir Hussein, Ghazwan Shaaya, Rohit Arora, Ali Al-Khazaali, Khalid Al-Khafaji, Hanan K Helu
Aortic stiffness (AS) is an important predictor of cardiovascular morbidity in humans. The present review discusses the possible pathophysiological mechanisms of AS and focuses on a survey of different therapeutic modalities for decreasing AS. The influence of several nonpharmacological interventions is described: decrease body weight, diet, aerobic exercise training, music, and continuous positive airway pressure therapy. The effects of different pharmacological drug classes on AS are also discussed: antihypertensive drugs-renin-angiotensin-aldosterone system drugs, beta-blockers, alpha-blockers, diuretics, and calcium channel blockers (CCBs)-advanced glycation end product cross-link breakers, statins, oral anti-diabetics, anti-inflammatory drugs, vitamin D, antioxidant vitamins, and endothelin-1 receptor antagonists...
July 12, 2016: American Journal of Therapeutics
Sonia Mahey, Rakesh Kumar, Rohit Arora, Jyoti Mahajan, Saroj Arora, Renu Bhardwaj, Ashwani Kumar Thukral
The present study investigates the anti-proliferative and apoptosis inducing mechanism of CoCl2·6H2O in PC-3 cancer cell line. Preliminary, three different forms of cobalt i.e., cobaltous (CoCl2·6H2O), macro-Co(II,III) oxide and nano-Co(II,III) oxide were screened for antiproliferative activity in PC-3 cell line. The CoCl2·6H2O being the most effective antiproliferative agent, hence it was further tested against lung (A549), prostrate (PC-3) and brain (IMR-32) cell lines. Human embryonic kidney cell line (293T) was used as a normal cell line to compare the toxicity of CoCl2·6H2O...
2016: SpringerPlus
Rohit Arora, Michela Di Michele, Elisabeth Stes, Elien Vandermarliere, Lennart Martens, Kris Gevaert, Erika Van Heerde, Joannes T M Linders, Dirk Brehmer, Edgar Jacoby, Pascal Bonnet
No abstract text is available yet for this article.
July 28, 2016: Journal of Medicinal Chemistry
Ritu Singhal, Paul R Reynolds, Jamie L Marola, L Elaine Epperson, Jyoti Arora, Rohit Sarin, Vithal Prasad Myneedu, Michael Strong, Max Salfinger
Fluoroquinolones (FQs) are broad-spectrum antibiotics recommended for the treatment of multidrug-resistant tuberculosis (MDR-TB) patients. FQ resistance, caused by mutations in the gyrA and gyrB genes of Mycobacterium tuberculosis, is increasingly reported worldwide; however, information on mutations occurring in strains from the Indian subcontinent is scarce. Hence, in this study, we aimed to characterize mutations in the gyrA and gyrB genes of acid-fast bacillus (AFB) smear-positive sediments or of M. tuberculosis isolates from AFB smear-negative samples from patients in India suspected of having MDR-TB...
September 2016: Journal of Clinical Microbiology
Rohit Arora, Bikram Singh, Adarsh Pal Vig, Saroj Arora
Eruca sativa is extensively used as raw and its oil is also used for cooking due to its exceptional flavour. The volatile nature of the hydrolytic products of glucosinolates makes the extraction difficult. The hydrodistillation method used previously yield very less amount of the extract as well as the absence of stirring in the round bottom flask causes burning of both the crushed seeds and the flask. To overcome these drawbacks, a method has been developed using magnetic stirrer and hot plate. The yield and composition of hydrolytic products in the extract with the modified method was increased along with an increase in the amount of major hydrolytic products as seen by GC-MS...
2016: SpringerPlus
Vineeta Nikhil, Shikha Jaiswal, Parul Bansal, Rohit Arora, Shalya Raj, Pulkit Malhotra
AIM: The purpose of this study was to evaluate the effect of phytic acid, ethylenediaminetetraacetic acid (EDTA), and chitosan solutions on the microhardness of human radicular dentin. MATERIALS AND METHODS: Thirty dentin specimens were randomly divided into three groups of 10 specimens each according to the irrigant used: G1 - 1% phytic acid, G2 - 17% EDTA, and G3 - 0.2% chitosan. A standardized volume of each chelating solution was used for 3 min. Dentin microhardness was measured before and after application at the cervical, middle, and apical levels with a Vickers indenter under a 200-g load and a 10-s dwell time...
March 2016: Journal of Conservative Dentistry: JCD
Rohit Arora, Sakshi Bhushan, Rakesh Kumar, Rahul Mannan, Pardeep Kaur, Bikram Singh, Ritika Sharma, Adarsh Pal Vig, Balbir Singh, Amrit Pal Singh, Saroj Arora
PURPOSE: Phenobarbital is a commonly employed antidepressant and anti-epileptic drug. The cancer promoting activity of this genotoxic xenobiotic is often ignored. It is responsible for oxidative stress leading to modulation in xenobiotic and antioxidative enzymes. Glucosinolates and more specifically their hydrolytic products are known for their antioxidative and anticancer activities. The present study involves the analysis of hepatoprotective effect of erucin (isolated from Eruca sativa (Mill...
April 15, 2016: Anti-cancer Agents in Medicinal Chemistry
Samia Aci-Sèche, Sonia Ziada, Abdennour Braka, Rohit Arora, Pascal Bonnet
Interest in the application of molecular dynamics (MD) simulations has increased in the field of protein kinase (PK) drug discovery. PKs belong to an important drug target class because they are directly involved in a number of diseases, including cancer. MD methods simulate dynamic biological and chemical events at an atomic level. This information can be combined with other in silico and experimental methods to efficiently target selected receptors. In this review, we present common and advanced methods of MD simulations and we focus on the recent applications of MD-based methodologies that provided significant insights into the elucidation of biological mechanisms involving PKs and into the discovery of novel kinase inhibitors...
April 2016: Future Medicinal Chemistry
Rakesh C Arora, Claudio Rigatto, Rohit K Singal
No abstract text is available yet for this article.
June 2016: Journal of Thoracic and Cardiovascular Surgery
Rohit Loomba, Parinda H Shah, Robert H Anderson, Yingyot Arora
So-called "heterotaxy" is a laterality defect characterized by isomerism of the thoracic organs and random arrangement of the abdominal organs. These findings go beyond anatomic curiosity and have functional implications. It is, thus, of the utmost importance to be able to properly identify these findings. Radiologic studies can be invaluable in determining anomalies in the central nervous, pulmonary, cardiovascular, gastrointestinal, genitourinary, and immunologic systems in patients with isomerism. Here, we review findings associated with isomerism and their importance in the setting of isomerism with the aim of ensuring that radiologists effectively describe findings in these patients and that cardiologists understand the wide variety of congenital malformations that may be present...
2016: Curēus
Rohit S Loomba, Saurabh Aggarwal, Rohit R Arora, Robert Anderson
INTRODUCTION: Bodily isomerism, or heterotaxy is a unique entity on which there is mirror imagery in various organ systems, leading to a deviation from the normal lateral arrangements of the viscera. Adults with such isomerism and associated congenital malformations of the heart are now reaching adulthood and developing long-term complications. This study investigates the prevalence and characteristics of pulmonary hypertension in adults with isomerism. METHODS: The 2012 iteration of the Nationwide Inpatient Sample was utilized and patients were identified as having or not having bodily isomerism and having or not having pulmonary hypertension...
June 2016: Therapeutic Advances in Respiratory Disease
Rohit S Loomba, Saurabh Aggarwal, Matthew Buelow, Karan Nijhawan, Navdeep Gupta, Venkata Alla, Rohit R Arora
INTRODUCTION: Children born with congenital malformations of the heart are increasingly surviving into adulthood. This population of patients possesses lesion-specific complication risks while still being at risk for common illnesses. Bodily isomerism or heterotaxy, is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of myocardial infarction in adults with bodily isomerism...
December 2016: Congenital Heart Disease
Saurabh Aggarwal, Rohit S Loomba, Rohit R Arora
Clopidogrel is a widely used drug in clinical practice. Controversy persists as to whether it interacts with proton pump inhibitors. Recently, research interest has grown in the area concerning an interaction of clopidogrel with calcium channel blockers. Multiple studies have been conducted to evaluate the effect of calcium channel blockers on the efficacy of clopidogrel, both in vitro and in vivo. The authors aim to present a systematic review of the published studies in the literature. Various terms were searched in PubMed, Web of Science, and The Cochrane database...
January 2016: American Journal of Therapeutics
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