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JOURNAL ARTICLE
Atamjit Singh, Kirandeep Kaur, Pallvi Mohana, Karanvir Singh, Aman Sharma, Jignesh Prajapati, Dweipayan Goswami, Neha Khosla, Uttam Kaur, Rajanbir Kaur, Rajinder Kaur, Abhineet Rana, Sandeep Kour, Puja Ohri, Saroj Arora, Renu Chadha, Preet Mohinder Singh Bedi
Bacterial resistance toward available therapeutic agents has become a nightmare for the healthcare system, causing significant mortality as well as prolonged hospitalization, thereby needing the urgent attention of research groups working on antimicrobial drug development worldwide. Molecular hybridization is a well-established tool for developing multifunctional compounds to tackle drug resistance. Inspired by the antibacterial profiles of isatin and thymol, along with the efficiency of a triazole linker in molecular hybridization, herein, we report the design, synthesis and antibacterial activity of a novel series of triazole tethered thymol-isatin hybrids...
January 25, 2024: RSC medicinal chemistry
#2
JOURNAL ARTICLE
Mayur Doke, Sandeep Appunni, Muni Rubens, Oscar Alcazar, Venkataraghavan Ramamoorthy, Anshul Saxena, Mukesh Roy, Atulya Khosla, Sandra Chaparro, Javier Jimenez
No abstract text is available yet for this article.
October 25, 2023: American Journal of Cardiology
#3
JOURNAL ARTICLE
Kelvin Chan, Abigail Conroy, Atulya Khosla, Muni Rubens, Anshul Saxena, Venkataraghavan Ramamoorthy, Mukesh Roy, Sandeep Appunni, Mayur Doke, Md Ashfaq Ahmed, Zhenwei Zhang, Peter McGranaghan, Sandra Chaparro, Javier Jimenez
BACKGROUND: Acute myocardial infarction (AMI) is one of the most lethal complications of COVID-19 hospitalization. In this study, we looked for the occurrence of AMI and its effects on hospital outcomes among COVID-19 patients. METHODS: Data from the 2020 California State Inpatient Database was used retrospectively. All COVID-19 hospitalizations with age ≥ 18 years were included in the analyses. Adverse hospital outcomes included in-hospital mortality, prolonged length of stay (LOS), vasopressor use, mechanical ventilation, and ICU admission...
October 24, 2023: Coronary Artery Disease
#4
Dhan B Shrestha, Jurgen Shtembari, Kerolus Shehata, Harsha Gondi, Anish Munagala, Esteffania Villegas Santamaria, Prakash Raj Oli, Daniela Kovacs, Sandeep Khosla
Spontaneous coronary artery dissection (SCAD) is a rare but increasingly recognized non-atherosclerotic cause of acute coronary syndrome. Common risk factors for SCAD are coronary atherosclerosis, female gender, peripartum period, systemic inflammatory conditions, and connective tissue disorders. It manifests as myocardial ischemia and infarction, arrhythmia, and sudden cardiac death. We present a case series of two young men and one young female with SCAD who had chest pain and were diagnosed with SCAD-associated ST-elevation myocardial infarction...
May 2023: Curēus
#5
JOURNAL ARTICLE
Kerolus Shehata, Dhan Bahadur Shrestha, Jurgen Shtembari, Roshan Khatiwada, Sandeep Khosla
de Winter ECG sign is an anterior ST-segment elevation myocardial infarction equivalent, which refers to an occlusion of the proximal left anterior descending (LAD) coronary artery with tall T waves and the absence of ST elevations in the precordial leads on the electrocardiogram (ECG). This sign is often under-recognized and not treated as an ST-segment elevation myocardial infarction which can increase the morbidity and mortality of such a life-threatening condition. Here we report a characteristic de Winter ECG sign involving left circumflex artery as culprit vessel, which was managed with PCI...
2023: Journal of Electrocardiology
#6
Jurgen Shtembari, Dhan B Shrestha, Prakash R Oli, Anish Munagala, Elda Mullaj, Kerolus Shehata, Daniela Kovacs, Sandeep Khosla
Anomalous origin of the left main coronary trunk from the right coronary sinus is a rare condition and is associated with a significantly increased risk of cardiac events, including sudden cardiac death, and it may pose difficulties in their management using revascularization strategies. We present a case of a 68-year-old man with worsening chest pain. Initial evaluation revealed ST elevation of the inferior wall leads and elevated troponins. He was diagnosed with ST-elevation myocardial infarction (STEMI) and sent for emergency cardiac catheterization...
March 2023: Curēus
#7
JOURNAL ARTICLE
Samriti Khosla, Sarika Verma, Shalika Datta, Sandeep Sharma, Rajeshwar Sharma, Harpreet Walia, Hiteshwari Sabrol, Nishi Madan, Mamta Rani, Nitin Sood, Yashbeer Singh, Vikas Kahol, Puja Rattan, Pranjal Pachpore, Sapna Sethi, Lakhmir Singh, K K Raina, R S Yadav, Sumedha Dutta, Sisir Roy, K Parthipan, G Saidaiah, Rajeshwar Mukherjee, M Srilatha, Vijeye Devuni, Minoo Aggarwal, Magesh
Stromal cells possess unique properties to regenerate themselves and cure various chronic illnesses. An easily available and ethical source for procurement of stromal cells is umbilical cord blood which is now being stored for future use. Vedic texts also describe the cord blood as a source of life. However, Indian traditions seem to preserve one more alternative for storage and procurement of stromal cells. Traditionally, in many parts of India, the umbilical cord stump is dried and stored for future use. It is used as a medicine for some illness and to treat infertility...
August 19, 2022: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
#8
JOURNAL ARTICLE
Divyesh Kumar, Treshita Dey, Divya Khosla, Sandeep Gedela, Arun S Oinam, Rakesh Kapoor
Introduction: Chemoradiation therapy (CRT) remains the treatment of choice for inoperable locally advanced esophageal cancer (LAEC). Several CRT regimens are existent in esophageal cancer, but definitive conclusions are lacking. We performed a pilot study to compare treatment outcome, survival, and toxicities in inoperable upper and middle third esophageal cancer patients undergoing CRT using either paclitaxel/carboplatin or cisplatin/5FU based regimen. Methods: Patients were randomised in two arms (arm A and arm B)...
April 2022: Journal of Cancer Research and Therapeutics
#9
REVIEW
Bhavya Padha, Sonali Verma, Prerna Mahajan, Vinay Gupta, Ajit Khosla, Sandeep Arya
Electrochemistry forms the base of large-scale production of various materials, encompassing numerous applications in metallurgical engineering, chemical engineering, electrical engineering, and material science. This field is important for energy harvesting applications, especially supercapacitors (SCs) and photovoltaic (PV) devices. This review examines various electrochemical techniques employed to fabricate and characterize PV devices and SCs. Fabricating these energy harvesting devices is carried out by electrochemical methods, including electroreduction, electrocoagulation, sol-gel process, hydrothermal growth, spray pyrolysis, template-assisted growth, and electrodeposition...
July 13, 2022: Critical Reviews in Analytical Chemistry
#10
REVIEW
Anoop Singh, Asha Sharma, Aamir Ahmed, Ashok K Sundramoorthy, Hidemitsu Furukawa, Sandeep Arya, Ajit Khosla
The electrochemical biosensors are a class of biosensors which convert biological information such as analyte concentration that is a biological recognition element (biochemical receptor) into current or voltage. Electrochemical biosensors depict propitious diagnostic technology which can detect biomarkers in body fluids such as sweat, blood, feces, or urine. Combinations of suitable immobilization techniques with effective transducers give rise to an efficient biosensor. They have been employed in the food industry, medical sciences, defense, studying plant biology, etc...
September 14, 2021: Biosensors
#11
Gaurav K Sharma, Wasey Ali Yadullahi Mir, Daniela Kovacs, Zeina Ibrahim, Daniel Benatar, Sandeep Khosla, Suman Gaire, Dhan B Shrestha
Ventricular septal defect (VSD) is the most common congenital cardiac anomaly in children and the second most common congenital cardiac anomaly in adults. The hemodynamic compromise associated with VSD is due to the shunt formation created by the abnormal communication between the right and left ventricles. While 85%-90% of small VSDs close spontaneously during the first year of life, some do not close spontaneously. If spontaneous closure does not occur during childhood, a VSD may persist into adulthood and may first be recognized after the development of a complication...
August 2021: Curēus
#12
JOURNAL ARTICLE
Sonali Verma, Vinay Gupta, Ajit Khosla, Suresh Kumar, Sandeep Arya
An efficient synthesis of the electrode material with abundant active sites is imperative for obtaining a flexible supercapacitor with excellent electrochemical performance. Herein, a novel flexible Ni@Co-Fe layered double hydroxides (LDH) core-shell nanowires supercapacitor negative electrode is synthesized using polycarbonate membrane on a copper substrate via an electrochemical deposition technique. The synthesized battery-type negative electrode exhibits remarkable specific capacitance of 1289 F/g at 1 A/g and excellent cycling stability with only 8...
February 28, 2020: Nanotechnology
#13
Ajit Sood, Vineet Ahuja, Saurabh Kedia, Vandana Midha, Ramit Mahajan, Varun Mehta, Ritu Sudhakar, Arshdeep Singh, Ajay Kumar, Amarender Singh Puri, Bailuru Vishwanath Tantry, Babu Ram Thapa, Bhabhadev Goswami, Banchha Nidhi Behera, Byong Duk Ye, Deepak Bansal, Devendra Desai, Ganesh Pai, Ghulam Nabi Yattoo, Govind Makharia, Hasitha Srimal Wijewantha, Jayanthi Venkataraman, K T Shenoy, Manisha Dwivedi, Manoj Kumar Sahu, Meenakshi Bajaj, Murdani Abdullah, Namrata Singh, Neelanjana Singh, Philip Abraham, Rajiv Khosla, Rakesh Tandon, S P Misra, Sandeep Nijhawan, Saroj Kant Sinha, Sawan Bopana, Sheela Krishnaswamy, Shilpa Joshi, Shivram Prasad Singh, Shobna Bhatia, Sudhir Gupta, Sumit Bhatia, Uday Chand Ghoshal
The recommendations 31 which recommend "VSL#3®", refer only to the product used in the cited literature and equivalent products independent from the present product labelings. This product is now known by the generic name "De Simone Formulation".
December 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#14
JOURNAL ARTICLE
Ajit Sood, Vineet Ahuja, Saurabh Kedia, Vandana Midha, Ramit Mahajan, Varun Mehta, Ritu Sudhakar, Arshdeep Singh, Ajay Kumar, Amarender Singh Puri, Bailuru Vishwanath Tantry, Babu Ram Thapa, Bhabhadev Goswami, Banchha Nidhi Behera, Byong Duk Ye, Deepak Bansal, Devendra Desai, Ganesh Pai, Ghulam Nabi Yattoo, Govind Makharia, Hasitha Srimal Wijewantha, Jayanthi Venkataraman, K T Shenoy, Manisha Dwivedi, Manoj Kumar Sahu, Meenakshi Bajaj, Murdani Abdullah, Namrata Singh, Neelanjana Singh, Philip Abraham, Rajiv Khosla, Rakesh Tandon, S P Misra, Sandeep Nijhawan, Saroj Kant Sinha, Sawan Bopana, Sheela Krishnaswamy, Shilpa Joshi, Shivram Prasad Singh, Shobna Bhatia, Sudhir Gupta, Sumit Bhatia, Uday Chand Ghoshal
INTRODUCTION: These Asian Working Group guidelines on diet in inflammatory bowel disease (IBD) present a multidisciplinary focus on clinical nutrition in IBD in Asian countries. METHODOLOGY: The guidelines are based on evidence from existing published literature; however, if objective data were lacking or inconclusive, expert opinion was considered. The conclusions and 38 recommendations have been subject to full peer review and a Delphi process in which uniformly positive responses (agree or strongly agree) were required...
June 2019: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#15
JOURNAL ARTICLE
Sivashanmugam Dhandapani, Apinderpreet Singh, Navneet Singla, Kokkula Praneeth, Ashish Aggarwal, Harsimrat B Sodhi, Sudhir S Pal, Sachin Goudihalli, Pravin Salunke, Sandeep Mohindra, Ajay Kumar, Vivek Gupta, Rajesh Chhabra, Kanchan K Mukherjee, Manoj K Tewari, Niranjan Khandelwal, Suresh N Mathuriya, Virender K Khosla, Sunil K Gupta
Background and Purpose- Though reports suggest decreasing fatality rates of subarachnoid hemorrhage with time, trends in outcome are not reported much especially from developing countries. This study was to analyze changes in outcome across 2 decades and elucidate probable factors. Methods- Prospective databases during 1996 to 2015 were reviewed for neurological outcome at 3 months in relation to demographics, Hunt and Hess grade, Fisher grade, and definitive treatment; and compared between 2 decades, contrasted by establishment of intensive care unit with continuous monitoring and other advancements...
December 2018: Stroke; a Journal of Cerebral Circulation
#16
COMPARATIVE STUDY
Vamsi Kodumuri, Senthil Balasubramanian, Aviral Vij, Sisir Siddamsetti, Ankur Sethi, Rommy Khalafallah, Sandeep Khosla
Coronary artery bypass grafting (CABG) is the preferred revascularization strategy for unprotected left main disease (UPLMD). Multiple small-scale trials and registry data showed that percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is a noninferior strategy with a Class IIa American College of Cardiology/American Heart Association recommendation in patients with high surgical risk and favorable anatomy. However, 2 recent large-scale randomized trials showed conflicting evidence. We conducted a meta-analysis of the existing data to compare outcomes of PCI with DES versus CABG for UPLMD...
April 15, 2018: American Journal of Cardiology
#17
JOURNAL ARTICLE
Varun Kumar, Sandeep Khosla, Monica Stancu
Imipenem-cilastatin and piperacillin-tazobactam are two antibiotics with broad antimicrobial coverage. Besides the many well established adverse effects of these drugs, there have been few case reports of hypokalemia. Here we present an interesting case of resistant hypokalemia caused by these drugs leading to Torsades de Pointes which has never been reported in the past. Hypokalemia resolved with discontinuation of piperacillin.
2017: Case Reports in Cardiology
#18
REVIEW
Sukhchain Singh, Mukesh Singh, Navsheen Grewal, Sandeep Khosla
BACKGROUND: The objective of this meta-analysis to evaluate safety and efficacy of transradial vs the transfemoral approach for primary percutaneous coronary intervention (PCI) in ST-segment elevation myocardial infarction (STEMI) patients. METHODS: Randomized controlled trials that compared the transfemoral vs the transradial approach in STEMI patients who underwent PCI were searched in PubMed, Embase, CENTRAL, Cumulative Index to Nursing and Allied Health Literature, and clinicaltrials...
June 2016: Canadian Journal of Cardiology
#19
JOURNAL ARTICLE
Garima Sharma, Divya Tej Sowpati, Prakruti Singh, Mehak Zahoor Khan, Rakesh Ganji, Sandeep Upadhyay, Sharmistha Banerjee, Vinay Kumar Nandicoori, Sanjeev Khosla
A mammalian cell utilizes DNA methylation to modulate gene expression in response to environmental changes during development and differentiation. Aberrant DNA methylation changes as a correlate to diseased states like cancer, neurodegenerative conditions and cardiovascular diseases have been documented. Here we show genome-wide DNA methylation changes in macrophages infected with the pathogen M. tuberculosis. Majority of the affected genomic loci were hypermethylated in M. tuberculosis infected THP1 macrophages...
April 26, 2016: Scientific Reports
#20
REVIEW
Sukhchain Singh, Mukesh Singh, Navsheen Grewal, Sandeep Khosla
OBJECTIVE: The authors aimed to conduct first systematic review and meta-analysis in STEMI patients evaluating vascular access site failure rate, fluoroscopy time, door to balloon time and contrast volume used with transradial vs transfemoral approach (TRA vs TFA) for PCI. METHODS: The PubMed, CINAHL, clinicaltrials.gov, Embase and CENTRAL databases were searched for randomized trials comparing TRA versus TFA. Random effect models were used to conduct this meta-analysis...
December 2015: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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