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Navdeep gupta

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https://www.readbyqxmd.com/read/29149207/evolution-of-the-metabolome-in-response-to-selection-for-increased-immunity-in-populations-of-drosophila-melanogaster
#1
Navdeep Gogna, Rakesh Sharma, Vanika Gupta, Kavita Dorai, N G Prasad
We used NMR-based metabolomics to test two hypotheses-(i) there will be evolved differences in the metabolome of selected and control populations even under un-infected conditions and (ii) post infection, the metabolomes of the selected and control populations will respond differently. We selected replicate populations of Drosophila melanogaster for increased survivorship (I) against a gram-negative pathogen. We subjected the selected (I) and their control populations (S) to three different treatments: (1) infected with heat-killed bacteria (i), (2) sham infected (s), and (3) untreated (u)...
2017: PloS One
https://www.readbyqxmd.com/read/28830069/accelerated-in-vivo-wound-healing-evaluation-of-microbial-glycolipid-containing-ointment-as-a-transdermal-substitute
#2
Sonam Gupta, Navdeep Raghuwanshi, Ritu Varshney, I M Banat, Amit Kumar Srivastava, Parul A Pruthi, Vikas Pruthi
A potent biosurfactant (BS) producing Bacillus licheniformis SV1 (NCBI GenBank Accession No. KX130852) was isolated from oil contaminated soil sample. Physicochemical investigations (TLC, HPLC, FTIR, GC-MS and NMR) revealed it to be glycolipid in nature. Fibroblast culture assay showed cytocompatibility and increased cell proliferation of 3T3/NIH fibroblast cells treated with this biosurfactant when checked using MTT assay and DAPI fluorescent staining. To evaluate the wound healing potential, BS ointment was formulated and checked for its spreadability and viscosity consistency...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28821166/perioperative-acute-myocardial-infarction-associated-with-non-cardiac-surgery
#3
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Jeffrey S Berger, Sripal Bangalore
Aims: Acute myocardial infarction (AMI) is a significant cardiovascular complication following non-cardiac surgery. We sought to evaluate national trends in perioperative AMI, its management, and outcomes. Methods and results: Patients who underwent non-cardiac surgery from 2005 to 2013 were identified using the United States National Inpatient Sample. Perioperative AMI was evaluated over time. Propensity score matching was used to compile a cohort of AMI patients managed invasively (defined as cardiac catheterization or coronary revascularization) vs...
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28488237/perioperative-bleeding-and-thrombotic-risks-in-patients-with-von-willebrand-disease
#4
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Sripal Bangalore, Jeffrey S Berger
Von Willebrand disease (VWD) is an inherited bleeding disorder that often manifests clinically with hemorrhage after invasive procedures. We investigated the association between a diagnosis of VWD and bleeding and thrombotic outcomes following major non-cardiac surgery in a large national database from the United States. Patients age ≥45 years requiring major non-cardiac surgery were identified from Healthcare Cost and Utilization Project's National Inpatient Sample data. Von Willebrand disease, perioperative major adverse cardiovascular events (MACE), thrombotic events, and hemorrhage were defined by ICD9 diagnosis codes...
July 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28050067/palbociclib-a-breakthrough-in-breast-carcinoma-in-women
#5
REVIEW
Ajay Kumar Gupta, Sushil Sharma, Navdeep Dahiya, D B S Brashier
Breast cancer (BC) is the most common cancer and leading cause of death in women worldwide. Cellular proliferation, growth, and division are tightly controlled by the cell-cycle regulatory machinery. An important pathway is cyclin-dependent kinases (CDKs) which regulate cell cycle and thus control transcriptional processes. In human cancer, multiple CDK family members are commonly deregulated. The cyclin D-CDK4/6-retinoblastoma (RB) protein-INK4 axis is particularly affected in many solid tumors which leads to cancer cell proliferation...
December 2016: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28030663/perioperative-major-adverse-cardiovascular-and-cerebrovascular-events-associated-with-noncardiac-surgery
#6
Nathaniel R Smilowitz, Navdeep Gupta, Harish Ramakrishna, Yu Guo, Jeffrey S Berger, Sripal Bangalore
Importance: Major adverse cardiovascular and cerebrovascular events (MACCE) are a significant source of perioperative morbidity and mortality following noncardiac surgery. Objective: To evaluate national trends in perioperative cardiovascular outcomes and mortality after major noncardiac surgery and to identify surgical subtypes associated with cardiovascular events using a large administrative database of United States hospital admissions. Design, Setting, Participants: Patients who underwent major noncardiac surgery from January 2004 to December 2013 were identified using the National Inpatient Sample...
February 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/27855508/bioanalytical-qualification-of-clinical-biomarker-assays-in-plasma-using-a-novel-multi-analyte-simple-plex-%C3%A2-platform
#7
Vinita Gupta, Teresa Davancaze, Jeremy Good, Navdeep Kalia, Michael Anderson, Jeffrey J Wallin, Ann Brady, An Song, Wenfeng Xu
AIM: Immune-checkpoint inhibitors are presumed to break down the tolerogenic state of immune cells by activating T-lymphocytes that release cytokines and enhance effector cell function for elimination of tumors. Measurement of cytokines is being pursued for better understanding of the mechanism of action of immune-checkpoint inhibitors, as well as to identify potential predictive biomarkers. RESULTS: In this study, we show bioanalytical qualification of cytokine assays in plasma on a novel multi-analyte immunoassay platform, Simple Plex(™)...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27846456/management-and-outcomes-of-acute-myocardial-infarction-in-patients-with-chronic-kidney-disease
#8
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Rina Mauricio, Sripal Bangalore
BACKGROUND: Chronic kidney disease (CKD) is associated with cardiovascular disease and acute myocardial infarction (AMI). Contemporary management and outcomes of AMI in patients with CKD have not been reported. METHODS: We analyzed United States National Inpatient Sample data for patients admitted with AMI with or without CKD from 2007 to 2012. Propensity score matching was used to identify patients with AMI and CKD with similar baseline characteristics who were managed invasively (cardiac catheterization, percutaneous coronary intervention [PCI], or coronary artery bypass graft surgery [CABG]) or conservatively...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27705890/influence-of-human-immunodeficiency-virus-seropositive-status-on-the-in-hospital-management-and-outcomes-of-patients-presenting-with-acute-myocardial-infarction
#9
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, John T Coppola, Sripal Bangalore
OBJECTIVES: Human immunodeficiency virus (HIV) seropositive individuals are predisposed to acute myocardial infarction (AMI). We sought to evaluate management strategies and outcomes of AMI in patients with HIV in the contemporary era. METHODS: We analyzed data from the National Inpatient Sample from 2002 to 2011 for patients admitted with AMI with or without HIV. Propensity-score matching was used to identify HIV seropositive AMI patients with similar characteristics who were managed invasively (cardiac catheterization, percutaneous coronary intervention [PCI], or coronary artery bypass graft surgery [CABG]) or conservatively...
October 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27617425/endovascular-therapy-for-acute-ischemic-stroke-with-occlusion-of-the-middle-cerebral-artery-m2-segment
#10
MULTICENTER STUDY
Amrou Sarraj, Navdeep Sangha, Muhammad Shazam Hussain, Dolora Wisco, Nirav Vora, Lucas Elijovich, Nitin Goyal, Michael Abraham, Manoj Mittal, Lei Feng, Abel Wu, Vallabh Janardhan, Suman Nalluri, Albert J Yoo, Megan George, Randall Edgell, Rutvij J Shah, Clark Sitton, Emilio Supsupin, Suhas Bajgur, M Carter Denny, Peng R Chen, Mark Dannenbaum, Sheryl Martin-Schild, Sean I Savitz, Rishi Gupta
Importance: Randomized clinical trials have shown the superiority of endovascular therapy (EVT) compared with best medical management for acute ischemic strokes with large vessel occlusion (LVO) in the anterior circulation. However, of 1287 patients enrolled in 5 trials, 94 with isolated second (M2) segment occlusions were randomized and 51 of these received EVT, thereby limiting evidence for treating isolated M2 segment occlusions as reflected in American Heart Association guidelines...
November 1, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27463590/rates-of-invasive-management-of-cardiogenic-shock-in-new-york-before-and-after-exclusion-from-public-reporting
#11
Sripal Bangalore, Yu Guo, Jinfeng Xu, Saul Blecker, Navdeep Gupta, Frederick Feit, Judith S Hochman
IMPORTANCE: Reduced rates of cardiac catheterization, percutaneous coronary intervention (PCI), and coronary artery bypass graft (CABG) are an unintended consequence of public reporting of cardiogenic shock outcomes in New York. OBJECTIVES: To evaluate whether the referral rates for cardiac catheterization, PCI, or CABG have improved in New York since cardiogenic shock was excluded from public reporting in 2008 and compare them with corresponding rates in Michigan, New Jersey, and California...
September 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27363956/ischemia-modified-albumin-ima-and-albumin-adjusted-ima-aaima-as-biomarkers-for-diabetic-retinopathy
#12
Varikasuvu Seshadri Reddy, Sumita Sethi, Poonam Agrawal, Navdeep Gupta, Renu Garg
INTRODUCTION: Oxidative stress has important role in the pathophysiology of diabetic retinopathy (DR). Ischemia modified albumin (IMA) has been recently considered as a marker of oxidative damage in diabetes. However, there is scarcity of published information about both IMA and albumin adjusted-IMA (AAIMA) in DR patients. OBJECTIVES: To evaluate the serum levels of IMA and AAIMA in patients with DR and in healthy controls. MATERIAL AND METHODS: This was a cross sectional study...
July 2015: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27105326/significance-of-ischemia-modified-albumin-as-a-simple-measure-of-oxidative-stress-and-its-discriminatory-ability-in-diabetic-retinopathy-literature-review-and-meta-analysis
#13
REVIEW
Varikasuvu Seshadri Reddy, Sumita Sethi, Navdeep Gupta, Poonam Agrawal, Ram Chander Siwach
PURPOSE: Oxidative stress (OXS) plays critical role in the development of diabetic retinopathy (DRP). Increased concentrations of serum ischemia-modified albumin (IMA) have been demonstrated as a novel and inexpensive measure of oxidative stress. Although few pilot studies have reported increased IMA in DRP, the available literature is limited to comprehensively describe the potential significance of IMA in predicting DRP. METHODS: The authors performed a meta-analysis to investigate IMA in DRP compared with control and diabetes mellitus subjects...
June 2016: Retina
https://www.readbyqxmd.com/read/26879777/acute-myocardial-infarction-in-adult-congenital-patients-with-bodily-isomerism
#14
Rohit S Loomba, Saurabh Aggarwal, Matthew Buelow, Karan Nijhawan, Navdeep Gupta, Venkata Alla, Rohit R Arora
INTRODUCTION: Children born with congenital malformations of the heart are increasingly surviving into adulthood. This population of patients possesses lesion-specific complication risks while still being at risk for common illnesses. Bodily isomerism or heterotaxy, is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of myocardial infarction in adults with bodily isomerism...
December 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/26853952/comparison-of-outcomes-of-patients-with-sepsis-with-versus-without-acute-myocardial-infarction-and-comparison-of-invasive-versus-noninvasive-management-of-the-patients-with-infarction
#15
COMPARATIVE STUDY
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Sripal Bangalore
Patients hospitalized with sepsis may be predisposed to acute myocardial infarction (AMI). The incidence, treatment, and outcomes of AMI in sepsis have not been studied. We analyzed data from the National Inpatient Sample from 2002 to 2011 for patients with a diagnosis of sepsis. The incidence of AMI as a nonprimary diagnosis was evaluated. Propensity score matching was used to identify a cohort of patients with secondary AMI and sepsis with similar baseline characteristics who were managed invasively (defined as cardiac catheterization, percutaneous coronary intervention [PCI], or coronary artery bypass graft [CABG] surgery) or conservatively...
April 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26481118/arrhythmias-in-adult-congenital-patients-with-bodily-isomerism
#16
Rohit S Loomba, Saurabh Aggarwal, Navdeep Gupta, Matthew Buelow, Venkata Alla, Rohit R Arora, Robert H Anderson
There are an increasing number of adults with congenital heart disease, some of whom have bodily isomerism. Bodily isomerism or heterotaxy is a unique clinical entity associated with congenital malformations of the heart which further increases the risk for future cardiovascular complications. We aimed to investigate the frequency of arrhythmias in adults with bodily isomerism. We utilized the 2012 iteration of the Nationwide Inpatient Sample to identify adult inpatient admissions associated with arrhythmias in patients with isomerism...
February 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/26312011/naloxegol-first-oral-peripherally-acting-mu-opioid-receptor-antagonists-for-opioid-induced-constipation
#17
Tejus Anantharamu, Sushil Sharma, Ajay Kumar Gupta, Navdeep Dahiya, Dick B Singh Brashier, Ashok Kumar Sharma
Opioid-induced constipation (OIC) is one of the most troublesome and the most common effects of opioid use leading to deterioration in quality of life of the patients and also has potentially deleterious repercussions on adherence and compliance to opioid therapy. With the current guidelines advocating liberal use of opioids by physicians even for non-cancer chronic pain, the situation is further complicated as these individuals are not undergoing palliative care and hence there cannot be any justification to subject these patients to the severe constipation brought on by opioid therapy which is no less debilitating than the chronic pain...
July 2015: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/26110179/outcome-of-distal-both-bone-leg-fractures-fixed-by-intramedulary-nail-for-fibula-mippo-in-tibia
#18
Anil Gupta, Rashid Anjum, Navdeep Singh, Shafiq Hackla
BACKGROUND: Fractures of the distal third of the tibia are mostly associated with a fibular fracture that often requires fixation. The preferred treatment of distal tibial fracture is the minimally invasive percutaneous plate osteosynthesis (MIPPO) procedure. However, there are no clear cut guidelines on fixation of the fibular fracture and currently most orthopedic surgeons use a plate osteosynthesis for the fibula as well. A common complication associated with dual plating is an increased chance of soft tissue necrosis, infection, and in some cases resulting in an exposed implant...
April 2015: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/25662046/trend-in-percutaneous-coronary-intervention-volume-following-the-courage-and-bari-2d-trials-insight-from-over-8-1-million-percutaneous-coronary-interventions
#19
Sripal Bangalore, Navdeep Gupta, Philippe Généreux, Yu Guo, Samir Pancholy, Frederick Feit
BACKGROUND: COURAGE and BARI-2D have questioned the utility of routine revascularization for the prevention of cardiovascular events in patients with stable ischemic heart disease (SIHD). On the other end of the spectrum, a routine invasive strategy in patients with acute coronary syndrome (ACS) is superior to a conservative strategy. The impact of the above trials on the trend in percutaneous coronary intervention (PCI) volume for SIHD and ACS is not known. METHODS: Data from the 2001-2011 Nationwide Inpatient Sample for discharges with PCI were used...
March 15, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25609868/denosumab-a-bone-antiresorptive-drug
#20
Navdeep Dahiya, Anjan Khadka, A K Sharma, A K Gupta, Nishith Singh, D B S Brashier
Bone remodeling is the continuous process by which old bone is removed by bone-resorbing cells, the osteoclasts and replaced by new bone synthesized by bone forming cells, the osteoblasts. Osteoporosis is characterized by a progressive loss of bone mass and microarchitecture, which leads to increased fracture risk. Denosumab, a human monoclonal antibody resembling natural IgG2 immunoglobulin, has antiresorptive activity and is distinguished from other antiresorptive drugs. It mimics osteoprotegerin (OPG) that binds to RANKL and hence does not allow RANKL to bind with RANK receptor, thereby inhibiting osteoclast differentiation, activation and survival exerting primarily antiresorptive action...
January 2015: Medical Journal, Armed Forces India
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