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Flavanols

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https://www.readbyqxmd.com/read/27898046/pro-and-antioxidant-activity-of-three-selected-flavan-type-flavonoids-catechin-eriodictyol-and-taxifolin
#1
Vladimir Chobot, Franz Hadacek, Gert Bachmann, Wolfram Weckwerth, Lenka Kubicova
The flavanol (±)-catechin shows an OH group but no 4-keto group on ring C (C3), and no conjugation between ring A and B. The related flavanone (+)-eriodictyol has a keto group on C4 but no 3-OH group on ring C. (+)-Taxifolin, another flavanone, has an OH on C3 and a keto group on C4 of the C ring. Deoxyribose degradation assay systems, with hydrogen peroxide and ascorbic acid either added or omitted, were performed in variants in which Fe(III) was added in a complex with ethylenediaminetetraacetic acid (EDTA)...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27897996/in-vitro-chemopreventive-properties-of-green-tea-rooibos-and-honeybush-extracts-in-skin-cells
#2
Tandeka U Magcwebeba, Pieter Swart, Sonja Swanevelder, Elizabeth Joubert, Wentzel C A Gelderblom
The chemopreventive properties of the herbal teas rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) have been demonstrated on mouse skin in vivo but the underlying mechanisms are not clear. The aim of the current study was to determine the anti-proliferative and pro-apoptotic activity of methanol and aqueous extracts of rooibos and two Cyclopia species in different skin cells, using green tea (Camellia sinensis) as a benchmark. Extracts were also characterised for their major individual polyphenols by high performance liquid chromatography and spectroscopically for the total polyphenol (TP) groups...
November 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27855905/bioactive-compounds-and-antioxidant-potential-in-tomato-pastes-as-affected-by-hot-and-cold-break-process
#3
Hasim Kelebek, Serkan Selli, Pınar Kadiroğlu, Osman Kola, Songul Kesen, Burçak Uçar, Başak Çetiner
The effects of hot and cold break industrial tomato paste production steps on phenolic compounds, carotenoids, organic acids, hydroxy methyl furfural (HMF) and other quality parameters of tomato pastes were investigated in this study. Phenolic compounds, carotenoids, organic acids, and HMF analyses were performed with LC-DAD-ESI-MS/MS and LC-DAD-RID was used for the sugar analyses. Furthermore, the antioxidant capacities of tomato pastes were assessed via the DPPH and ABTS methods. The increase of phenol acids at the processing steps of cold break production method was higher than the hot break production method...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27849355/acute-cocoa-flavanol-improves-cerebral-oxygenation-without-enhancing-executive-function-at-rest-or-after-exercise
#4
Lieselot Decroix, Cajsa Tonoli, Danusa D Soares, Semah Tagougui, Elsa Heyman, Romain Meeusen
Acute exercise-induced improvements in cognitive function are accompanied by increased (cerebral) blood flow and increased brain-derived neurotrophic factor (BDNF) levels. Acute cocoa flavanol (CF) intake may improve cognitive function, cerebral blood flow (in humans), and BNDF levels (in animals). This study investigated (i) the effect of CF intake in combination with exercise on cognitive function and (ii) cerebral hemodynamics and BDNF in response to CF intake and exercise. Twelve healthy men participated in this randomized, double-blind, crossover study...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27847974/liquid-chromatographic-electrospray-ionization-quadrupole-time-of-flight-tandem-mass-spectrometric-study-of-polyphenolic-composition-of-different-vaccinium-berry-species-and-their-comparative-evaluation
#5
Claudia Ancillotti, Lorenzo Ciofi, Daniele Rossini, Ugo Chiuminatto, Jianru Stahl-Zeng, Serena Orlandini, Sandra Furlanetto, Massimo Del Bubba
Ultra-high-performance liquid chromatography coupled with high-resolution quadrupole-time of flight mass spectrometry with both negative and positive ionization was used for comprehensively investigating the phenolic and polyphenolic compounds in berries from three spontaneous or cultivated Vaccinium species (i.e., Vaccinium myrtillus, Vaccinium uliginosum subsp. gaultherioides, and Vaccinium corymbosum). More than 200 analytes, among phenolic and polyphenolic compounds belonging to the classes of anthocyanins, monomeric and oligomeric flavonols, flavanols, dihydrochalcones, phenolic acids, together with other polyphenolic compounds of mixed structural characteristics, were identified...
November 15, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27845891/curviflorside-and-curviflorin-new-naphthalene-glycoside-and-flavanol-from-plicosepalus-curviflorus
#6
Nawal M Al Musayeib, Sabrin R M Ibrahim, Musarat Amina, Gadah A Al Hamoud, Gamal A Mohamed
The naphthalene glycosidecurviflorside [1,5-dihydroxy-8-methoxynaphthalene-2-O-β-D-xylopyranoside] (3) and the flavanol curviflorin [(+)-catechin-7-O-3″,4″-dihydroxybenzoate] (4), along with two known flavonoids: (+)-catechin (1) and quercetin (2) were isolated from the shoots of Plicosepalu scurviflorus Benth. (Loranthaceae) growing in Saudi Arabia and the chemical structures were elucidated by 2D-NMR spectroscopy.
November 15, 2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/27827474/the-prothrombotic-state-associated-with-obesity-induced-hypertension-is-reduced-by-cocoa-and-its-main-flavanols
#7
G M Rabadán-Chávez, E Reyes-Maldonado, L Quevedo-Corona, N Paniagua-Castro, G Escalona-Cardoso, M E Jaramillo-Flores
BACKGROUND: Little is known about the effects of cocoa and its main flavanols on the prothrombotic state associated with the development of hypertension in diet-induced obesity models. PURPOSE: To evaluate the effects of cocoa powder, cocoa extract and their main flavanols on plasma biomarkers related to impaired coagulation and fibrinolysis and its association with hypertension and obesity-related metabolic disorders in rats fed a hypercaloric diet. METHODS: Male Wistar rats were randomly assigned to 7 treatment groups (n = 7): normal diet (ND); hypercaloric diet control group (HCD); HCD + cocoa powder (CO); HCD + cocoa extract (CO-EX); HCD + (-)-epicatechin (EPI); HCD + (+)-catechin (CAT); and HCD + procyanidin B2 (PB2)...
November 9, 2016: Food & Function
https://www.readbyqxmd.com/read/27812583/the-modulatory-effect-of-infusions-of-green-tea-oolong-tea-and-black-tea-on-gut-microbiota-in-high-fat-induced-obese-mice
#8
Zhibin Liu, Zhichao Chen, Hongwen Guo, Dongping He, Huiru Zhao, Zhiyao Wang, Wen Zhang, Lan Liao, Chen Zhang, Li Ni
Tea consumption has been identified to have an anti-obesity effect. Whether it is associated with gut microbiota modulation is investigated in this study. Phenolic profiles of infusions of green tea, oolong tea and black tea were comprehensively compared first, by utilizing ultra-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOFMS). Subsequently, high-fat-diet induced obese C57BL/6J mice were orally administered these three types of tea infusions for 13 weeks to evaluate their anti-obesity and gut microbiota modulatory effects...
November 4, 2016: Food & Function
https://www.readbyqxmd.com/read/27810677/effects-of-ambient-solar-uv-radiation-on-grapevine-leaf-physiology-and-berry-phenolic-composition-along-one-entire-season-under-mediterranean-field-conditions
#9
María-Ángeles Del-Castillo-Alonso, María P Diago, Rafael Tomás-Las-Heras, Laura Monforte, Gonzalo Soriano, Javier Martínez-Abaigar, Encarnación Núñez-Olivera
In the present study we assessed the effects of ambient solar UV exclusion on leaf physiology, and leaf and berry skin phenolic composition, of a major grapevine cultivar (Tempranillo) grown under typically Mediterranean field conditions over an entire season. In general, the effects of time were stronger than those of UV radiation. Ambient UV caused a little stressing effect (eustress) on leaf physiology, with decreasing net photosynthesis rates and stomatal conductances. However, it was not accompanied by alterations in Fv/Fm or photosynthetic pigments, and was partially counterbalanced by the UV-induced accumulation of protective flavonols...
October 22, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27799805/clinical-effects-of-an-oral-supplement-rich-in-antioxidants-on-skin-radiance-in-women
#10
Marion Dumoulin, David Gaudout, Benoit Lemaire
BACKGROUND: Environmental factors impact the skin aging resulting in decrease of skin radiance. Nutrition and particularly antioxidants could help to fight against skin degradation. OBJECTIVE: The aim of this study was to evaluate the effects of an oral supplement rich in specific antioxidants, SkinAx(2TM), on the improvement of the skin radiance in women. METHODS: The open-label clinical study enrolled 35 women, aged 40-70, with facial dull complexion...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27794599/environmental-factors-correlated-with-the-metabolite-profile-of-vitis-vinifera-cv-pinot-noir-berry-skins-along-a-european-latitudinal-gradient
#11
María-Ángeles Del-Castillo-Alonso, Antonella Castagna, Kristóf Csepregi, Éva Hideg, Gabor Jakab, Marcel A K Jansen, Tjaša Jug, Laura Llorens, Anikó Mátai, Johann Martínez-Lüscher, Laura Monforte, Susanne Neugart, Julie Olejnickova, Annamaria Ranieri, Katharina Schoedll-Hummel, Monika Schreiner, Gonzalo Soriano, Péter Teszlák, Susanne Tittmann, Otmar Urban, Dolors Verdaguer, Gaetano Zipoli, Javier Martínez-Abaigar, Encarnacion Núñez-Olivera
Mature berries of Pinot Noir grapevines were sampled across a latitudinal gradient in Europe, from southern Spain to central Germany. Our aim was to study the influence of latitude-dependent environmental factors on the metabolite composition (mainly phenolic compounds) of berry skins. Solar radiation variables were positively correlated with flavonols and flavanonols and, to a lesser extent, with stilbenes and cinnamic acids. The daily means of global and erythematic UV solar radiation over long periods (bud break-veraison, bud break-harvest and veraison-harvest), and the doses and daily means in shorter development periods (5-10 days before veraison and harvest) were the variables best correlated with the phenolic profile...
October 31, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27776287/antimicrobial-effect-of-the-tunisian-nana-variety-punica-granatum-l-extracts-against-salmonella-enterica-serovars-kentucky-and-enteritidis-isolated-from-chicken-meat-and-phenolic-composition-of-its-peel-extract
#12
Ben Ajmia Wafa, Mohamed Makni, Sonda Ammar, Lamia Khannous, Amal Ben Hassana, Mohamed Bouaziz, Nour Eddine Es-Safi, Radhouane Gdoura
Punica granatum L. is widely recognized for its potency against a broad spectrum of bacterial pathogens. The purpose of this study was to explore the inhibitory and the bactericidal activities of Punica granatum against Salmonella strains. The effect of extracts obtained from different parts (peels, seeds, juice and flowers) of pomegranate and using different solvents against Salmonella enterica serovars Kentucky and Enteritidis isolated from chicken meat was thus investigated. Salmonella strains were identified with the standard API-20E system and confirmed by real time PCR...
October 11, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27747228/black-currant-ribes-nigrum-l-and-bilberry-vaccinium-myrtillus-l-fruit-juices-inhibit-adhesion-of-asaia-spp
#13
Hubert Antolak, Agata Czyzowska, Dorota Kregiel
The aim of the study was to evaluate the activity of high-polyphenolic black currant (Ribes nigrum L.) and bilberry (Vaccinium myrtillus L.) juices against bacterial strains Asaia lannensis and Asaia bogorensis isolated as spoilage of commercial soft drinks. The composition of fruit juices was evaluated using chromatographic techniques HPLC and LC-MS. The adhesion to glass, polystyrene, and polyethylene terephthalate in two different culture media was evaluated by luminometry and the plate count method. The major anthocyanins in the V...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27738868/phytochemicals-monosaccharides-and-elemental-composition-of-the-non-pomace-constituent-of-organic-and-conventional-grape-juices-vitis-labrusca-l-effect-of-drying-on-the-bioactive-content
#14
Isabel Cristina da Silva Haas, Isabela Maia Toaldo, Jefferson Santos de Gois, Daniel L G Borges, Carmen Lúcia de Oliveira Petkowicz, Marilde T Bordignon-Luiz
Grape and grape derivatives contain a variety of antioxidants that have gain increasing interest for functional foods applications. The chemical composition of grapes is mainly related to grape variety and cultivation factors, and each grape constituent exhib its unique characteristics regarding its bioactive properties. This study investigated the chemical composition and the effect of drying on the bioactive content of the non-pomace constituent obtained in the processing of organic and conventional grape juices from V...
October 13, 2016: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/27696933/high-flavanol-and-high-theobromine-versus-low-flavanol-and-low-theobromine-chocolate-to-improve-uterine-artery-pulsatility-index-a-double-blind-randomized-clinical-trial
#15
Emmanuel Bujold, Vicky Leblanc, Élise Lavoie-Lebel, Asma Babar, Mario Girard, Lionel Poungui, Claudine Blanchet, Isabelle Marc, Simone Lemieux, Abdous Belkacem, Elhadji Laouan Sidi, Sylvie Dodin
OBJECTIVE: To evaluate the impact of high-flavanol and high-theobromine (HFHT) chocolate in women at risk of preeclampsia (PE). STUDY DESIGN: We conducted a single-center randomized controlled trial including women with singleton pregnancy between 11 and 14 weeks gestation who had bilateral abnormal uterine artery (UtA) waveforms (notching) and elevated pulsatility index (PI). Participants were randomized to either HFHT or low-flavanol and low-theobromine (LFLT) chocolate (30 grams daily for a total of 12 weeks)...
October 3, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27683874/cocoa-flavanol-intake-and-biomarkers-for-cardiometabolic-health-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
Xiaochen Lin, Isabel Zhang, Alina Li, JoAnn E Manson, Howard D Sesso, Lu Wang, Simin Liu
BACKGROUND: Cocoa flavanols may improve cardiometabolic health. Evidence from small short-term randomized clinical trials (RCTs) remains inconsistent, and large long-term RCTs testing the efficacy of cocoa flavanols are still lacking. OBJECTIVE: We performed a systematic review and meta-analysis of RCTs to quantify the effect of cocoa flavanol intake on cardiometabolic biomarkers. METHODS: We searched PubMed, Web of Science, and the Cochrane Library for RCTs that evaluated the effects of cocoa flavanols on biomarkers relevant to vascular disease pathways among adults...
November 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27671741/the-potential-role-of-polyphenols-in-the-modulation-of-skin-cell-viability-by-aspalathus-linearis-and-cyclopia-spp-herbal-tea-extracts-in-vitro
#17
Tandeka Unathi Magcwebeba, Sylvia Riedel, Sonja Swanevelder, Pieter Swart, Dalene De Beer, Elizabeth Joubert, Wentzel Christoffel Andreas Gelderblom
OBJECTIVES: The relationship between polyphenol constituents, antioxidant properties of aqueous and methanol extracts of green tea (Camellia sinensis), the herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.), against skin cell viability was investigated in vitro. METHODS: The effect of extracts, characterised in terms of polyphenol content and antioxidant properties, on cell viability of premalignant, normal and malignant skin cells was determined...
September 27, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27664662/phenolics-antioxidant-capacity-and-bioaccessibility-of-chicory-varieties-cichorium-spp-grown-in-turkey
#18
Yasemin Sahan, Ozan Gurbuz, Metin Guldas, Nurcan Degirmencioglu, Aynur Begenirbas
In this study, the changes in phenolics, anthocyanin, antioxidant capacity, and bioaccessibility of chicory varieties (Cichorium spp.) in Turkey were investigated. A total of 19 phenolic standards were screened in the chicory varieties studied and the most abundant compounds in the samples, extracted with methanol, were phenolic acids, syringic (2.54mg/kg) and trans-ferulic acid (1.85mg/kg), whilst (+)-catechin was the major flavanol. The highest flavanol content using either methanol or ethanol was determined in the green chicory samples (0...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27624317/rat-health-status-affects-bioavailability-target-tissue-levels-and-bioactivity-of-grape-seed-flavanols
#19
Maria Margalef, Zara Pons, Lisard Iglesias-Carres, Mar Quiñones, Francisca Isabel Bravo, Anna Arola-Arnal, Begoña Muguerza
SCOPE: Studying the flavanol metabolism is essential to identify bioactive compounds, as beneficial effects of flavanols have been attributed to their metabolic products. However, host-related factors, including pathological conditions, may affect flavanol metabolism and, thus, their bioactivity. This study aims to elucidate whether hypertension affects grape seed flavanol metabolism, influencing their bioactivity in relation to hypertension. MATERIALS AND RESULTS: Grape seed flavanols' effect on blood pressure (BP) was studied in spontaneously hypertensive rats (SHR) and healthy Wistar rats 6 h after grape seed extract administration (375 mg/kg)...
September 14, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27605464/-epicatechin-induces-physiological-cardiac-growth-by-activation-of-the-pi3k-akt-pathway-in-mice
#20
Sergio De Los Santos, Viridiana García-Pérez, Sauri Hernández-Reséndiz, Carlos Palma-Flores, Carlos J González-Gutiérrez, Cecilia Zazueta, Patricia Canto, Ramón M Coral-Vázquez
SCOPE: The flavanol (-)-epicatechin (Epi) has cardioprotective effects and improves physical capacity in normal mice. In addition, Epi increases nitric oxide (NO) production by activation of both PI3K/Akt or Ca(2+) /CaMI/CaMKII (where Akt is protein kinase B; PI3K is phosphoinositide 3-kinase; CaMI is calmodulin; CaMKII is Ca(2+) /calmodulin-dependent protein kinase II) signaling pathways, which have been associated with physiological and pathological cardiac hypertrophy, respectively...
September 8, 2016: Molecular Nutrition & Food Research
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