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Indole 3 Carbinol

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https://www.readbyqxmd.com/read/28137215/targeting-cancer-stem-cells-for-chemoprevention-of-pancreatic-cancer
#1
Dharmalingam Subramaniam, Gaurav Kaushik, Prasad Dandawate, Shrikant Anant
Pancreatic ductal adenocarcinoma is one of the deadliest cancers worldwide and the fourth leading cause of cancer-related deaths in United States. Regardless of the advances in molecular pathogenesis and consequential efforts to suppress the disease, this cancer remains a major health problem in United States. By 2030, the projection is that pancreatic cancer will be climb up to be the second leading cause of cancer-related deaths in the United States. Pancreatic cancer is a rapidly invasive and highly metastatic cancer, and does not respond to standard therapies...
January 26, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28117016/food-as-pharma-the-case-of-glucosinolates
#2
Edoardo Capuano, Matthijs Dekker, Ruud Verkerk, Teresa Oliviero
BACKGROUND: Glucosinolates (GLSs) are dietary plant secondary metabolites occurring in the order Brassicales with potential health effects, in particular as anti-carcinogenic compounds. GLSs are converted into a variety of breakdown products (BPs) upon plant tissue damage and by the gut microbiota. GLS biological activity is related to BPs rather than to GLSs themselves. METHODS: we have reviewed the most recent scientific literature on the metabolic fate and the biological effect of GLSs with particular emphasis on the epidemiological evidence for health effect and evidence from clinical trials...
January 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27979631/indole-3-carbinol-i3c-analogues-are-potent-small-molecule-inhibitors-of-nedd4-1-ubiquitin-ligase-activity-that-disrupt-proliferation-of-human-melanoma-cells
#3
Jeanne G Quirit, Sergey N Lavrenov, Kevin Poindexter, Janice Xu, Christine Kyauk, Kathleen A Durkin, Ida Aronchik, Thomas Tomasiak, Yaroslav A Solomatin, Maria N Preobrazhenskaya, Gary L Firestone
The HECT domain-containing E3 ubiquitin ligase NEDD4-1 (Neural precursor cell Expressed Developmentally Down regulated gene 4-1) is frequently overexpressed in human cancers and displays oncogenic-like properties through the ubiquitin-dependent regulation of multiple protein substrates. However, little is known about small molecule enzymatic inhibitors of HECT domain-containing ubiquitin ligases. We now demonstrate that indole-3-carbinol (I3C), a natural anti-cancer phytochemical derived from cruciferous vegetables such as cabbage and broccoli, represents a new chemical scaffold of small molecule enzymatic inhibitors of NEDD4-1...
December 12, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27916218/fenofibrate-attenuates-malignant-hypertension-by-suppression-of-the-renin-angiotensin-system-a-study-in-cyp1a1-ren-2-transgenic-rats
#4
Šárka Jíchová, Šárka Doleželová, Libor Kopkan, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Luděk Červenka
BACKGROUND: Malignant hypertension is a life-threatening condition, and its pathophysiology is still poorly understood. The present study was designed to evaluate the role of interaction of the renin-angiotensin system with 20-hydroxyeicosatetraenoic acid (20-HETE), a product of cytochrome P450 (CYP)-dependent ω-hydroxylase pathway, in the pathophysiology of angiotensin II (ANG II)-dependent malignant hypertension in Cyp1a1-Ren-2 transgenic rats. METHODS: Malignant hypertension was induced by 12 days׳ dietary administration of 0...
December 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27823732/cancer-chemoprevention-by-dietary-phytochemicals-epidemiological-evidence
#5
REVIEW
Raúl Baena Ruiz, Pedro Salinas Hernández
BACKGROUND: In recent years, natural compounds called "phytochemicals", which are present in fruits, vegetables, and plants, have received special attention due to their potential to interfere with tumour formation and development. Many of these phytochemicals are being used in chemoprevention strategies. However, the scientific evidence regarding the modification of cancer risk continues to be debated. OBJECTIVE: The aim of this paper is to review the current scientific evidence and the most relevant epidemiological studies regarding the consumption or use of phytochemicals and their effects on the incidence of cancer...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27791173/prolactin-alters-blood-pressure-by-modulating-the-activity-of-endothelial-nitric-oxide-synthase
#6
Albert S Chang, Ruriko Grant, Hirofumi Tomita, Hyung-Suk Kim, Oliver Smithies, Masao Kakoki
Increased levels of a cleaved form of prolactin (molecular weight 16 kDa) have been associated with preeclampsia. To study the effects of prolactin on blood pressure (BP), we generated male mice with a single-copy transgene (Tg; inserted into the hypoxanthine-guanine phosphoribosyltransferase locus) that enables inducible hepatic production of prolactin and its cleavage product. The Tg is driven by the indole-3-carbinol (I3C)-inducible rat cytochrome P450 1A1 promoter. When the Tg mice were fed normal chow (NC), plasma prolactin concentrations were comparable to those in female WT mice in the last third of pregnancy, and BP was lower than in WT mice (∼95 mm Hg vs...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27783115/aryl-hydrocarbon-receptor-signaling-modifies-toll-like-receptor-regulated-responses-in-human-dendritic-cells
#7
Sarah Kado, W L William Chang, Aimy Nguyen Chi, Monika Wolny, David M Shepherd, Christoph F A Vogel
Currently, it is not well understood how ligands of the aryl hydrocarbon receptor (AhR) modify inflammatory responses triggered by Toll-like receptor (TLR) agonists in human dendritic cells (DCs). Here, we show that AhR ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the tryptophan derivatives 6-formylindolo[3,2-b] carbazole (FICZ), kynurenine (kyn), and the natural dietary compound indole-3-carbinol (I3C) differentially modify cytokine expression in human monocyte-derived DCs (MoDCs). The results show that TLR-activated MoDCs express higher levels of AhR and are more sensitive toward the effects of AhR ligands...
October 25, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27700072/effect-of-oral-administration-of-3-3-diindolylmethane-on-dextran-sodium-sulfate-induced-acute-colitis-in-mice
#8
Eun-Joo Jeon, Munkhtugs Davaatseren, Jin-Taek Hwang, Jae Ho Park, Haeng Jeon Hur, Ae Sin Lee, Mi Jeong Sung
In patients with inflammatory bowel disease (IBD), inflammation is induced and maintained by lymphangiogenesis and angiogenesis. 3,3'-Diindolylmethane (DIM) is a natural product formed in acidic conditions from indole-3-carbinol in cruciferous vegetables, and it is known for its chemotherapeutic activity. This study evaluated DIM's effects on angiogenesis, lymphangiogenesis, and inflammation in a mouse colitis model. Experimental colitis was induced in mice by administering 3% dextran sulfate sodium (DSS) via drinking water...
October 4, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27671815/indole-3-carbinol-and-its-role-in-chronic-diseases
#9
Barbara Licznerska, Wanda Baer-Dubowska
Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindolylmethane (DIM) exert several biological activities on cellular and molecular levels, which contribute to their well-recognized chemoprevention potential. Initially, these compounds were classified as blocking agents that increase drug-metabolizing enzyme activity. Now it is widely accepted that I3C and DIM affect multiple signaling pathways and target molecules controlling cell division, apoptosis, or angiogenesis deregulated in cancer cells...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27612096/indole-3-carbinol-enhances-sorafenib-cytotoxicity-in-hepatocellular-carcinoma-cells-a-mechanistic-study
#10
Mai M Abdelmageed, Reem N El-Naga, Ebtehal El-Demerdash, Mohamed M Elmazar
Sorafenib is the only chemotherapeutic agent currently approved for unresectable hepatocellular carcinoma (HCC). However, poor response rates have been widely reported. Indole-3-carbinol (I3C) is a potential chemopreventive phytochemical. The present study aimed to explore the potential chemomodulatory effects of I3C on sorafenib in HCC cells as well as the possible underlying mechanisms. I3C exhibited a greater cytotoxicity in HepG2 cells compared to Huh-7 cells (p < 0.0001). Moreover, the co-treatment of HepG2 cells with I3C and sorafenib was more effective (p = 0...
September 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27609747/targeting-cancer-stem-cells-and-signaling-pathways-by-phytochemicals-novel-approach-for-breast-cancer-therapy
#11
REVIEW
Prasad R Dandawate, Dharmalingam Subramaniam, Roy A Jensen, Shrikant Anant
Breast cancer is the most common form of cancer diagnosed in women worldwide and the second leading cause of cancer-related deaths in the USA. Despite the development of newer diagnostic methods, selective as well as targeted chemotherapies and their combinations, surgery, hormonal therapy, radiotherapy, breast cancer recurrence, metastasis and drug resistance are still the major problems for breast cancer. Emerging evidence suggest the existence of cancer stem cells (CSCs), a population of cells with the capacity to self-renew, differentiate and be capable of initiating and sustaining tumor growth...
October 2016: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/27586534/relationship-between-chemical-structure-and-antimicrobial-activities-of-isothiocyanates-from-cruciferous-vegetables-against-oral-pathogens
#12
Mi-Ok Ko, Mi-Bo Kim, Sang-Bin Lim
We evaluated the potentials of 10 isothiocyanates (ITCs) from cruciferous vegetables and radish root hydrolysate for inhibiting the growth of oral pathogens, with an emphasis on assessing any structure-function relationship. Structural differences in ITCs impacted their antimicrobial activities against oral pathogens differently. The indolyl ITC (indol-3-carbinol) was the most potent inhibitor of the growth of oral pathogens, followed by aromatic ITCs (benzyl ITC (BITC) and phenylethyl ITC (PEITC)) and aliphatic ITCs (erucin, iberin, and sulforaphene)...
December 28, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27580128/reversible-toxic-effects-of-the-dietary-supplement-indole-3-carbinol-in-an-immune-compromised-rodent-model-intestine-as-the-main-target
#13
Arnetta Fletcher, Haiqiu Huang, Lu Yu, Quynhchi Pham, Liangli Yu, Thomas T Y Wang
Dietary supplements are widely used in the United States, but the safety issue remains unresolved. Immuno-deficient or immuno-compromised patients, estimated to exceed 10 million in the United States, are known to use dietary supplements. This population potentially may be susceptible to supplements' adverse effects. The cruciferous vegetable-derived indole-3-carbinol (I3C) is known for its possible protective effects against a number of chronic diseases and is commercially available as a dietary supplement...
May 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27579302/bioavailability-of-glucosinolates-and-their-breakdown-products-impact-of-processing
#14
REVIEW
Francisco J Barba, Nooshin Nikmaram, Shahin Roohinejad, Anissa Khelfa, Zhenzhou Zhu, Mohamed Koubaa
Glucosinolates are a large group of plant secondary metabolites with nutritional effects, and are mainly found in cruciferous plants. After ingestion, glucosinolates could be partially absorbed in their intact form through the gastrointestinal mucosa. However, the largest fraction is metabolized in the gut lumen. When cruciferous are consumed without processing, myrosinase enzyme present in these plants hydrolyzes the glucosinolates in the proximal part of the gastrointestinal tract to various metabolites, such as isothiocyanates, nitriles, oxazolidine-2-thiones, and indole-3-carbinols...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27541624/simultaneous-determination-and-validation-of-oncrasin-266-and-its-metabolites-by-hplc-ms-ms-application-to-a-pharmacokinetic-study
#15
Lyndsey White, Shuhong Wu, Jing Ma, Bingliang Fang, Dong Liang
Oncrasins are a class of RNA polymerase II inhibitors. Oncrasin-72 is an indole-3 carbinol analog that has shown to inhibit growth and induce the cell death of various human cancer cell lines. Oncrasin-266, a prodrug of oncrasin-72, has been shown to have improved pharmacokinetic properties and safety than Oncrasin-72. With respect to the potential therapeutic advantages of this class of compounds, there is a need for further preclinical assessment for future clinical trials. The development of and validation of an analytical method is essential for the quantification of oncrasins in biological fluids for pharmacokinetic studies...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27538743/harnessing-the-power-of-cruciferous-vegetables-developing-a-biomarker-for-brassica-vegetable-consumption-using-urinary-3-3-diindolylmethane
#16
Naomi Fujioka, Benjamin W Ransom, Steven G Carmella, Pramod Upadhyaya, Bruce R Lindgren, Astia Roper-Batker, Dorothy K Hatsukami, Vincent A Fritz, Charles Rohwer, Stephen S Hecht
Glucobrassicin in Brassica vegetables gives rise to indole-3-carbinol (I3C), a compound with potent anticancer effects in preclinical models. We previously showed that the urinary metabolite 3,3'-diindolylmethane (DIM) could discriminate between volunteers fed high and low doses of Brassica vegetables. However, the quantitative relationship between glucobrassicin exposure and urinary DIM level is unclear. We conducted a clinical trial to examine the hypotheses that a range of glucobrassicin exposure from Brassica vegetables is reflected in urinary DIM and that this effect plateaus...
October 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27527145/suppression-of-lipid-accumulation-by-indole-3-carbinol-is-associated-with-increased-expression-of-the-aryl-hydrocarbon-receptor-and-cyp1b1-proteins-in-adipocytes-and-with-decreased-adipocyte-stimulated-endothelial-tube-formation
#17
Mei-Lin Wang, Shyh-Hsiang Lin, Yuan-Yu Hou, Yue-Hwa Chen
This study investigated the effects of indole-3-carbinol (I3C) on adipogenesis- and angiogenesis-associated factors in mature adipocytes. The cross-talk between mature adipocytes and endothelial cells (ECs) was also explored by cultivating ECs in a conditioned medium (CM) by using I3C-treated adipocytes. The results revealed that I3C significantly inhibited triglyceride accumulation in mature adipocytes in association with significantly increased expression of AhR and CYP1B1 proteins as well as slightly decreased nuclear factor erythroid-derived factor 2-related factor 2, hormone-sensitive lipase, and glycerol-3-phosphate dehydrogenase expression by mature adipocytes...
August 3, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27508569/-op-8c-04-the-flow-detection-role-of-the-vascular-epithelial-sodium-channel-enac-in-an-experimental-model-of-hypertension-the-novel-target-for-spironolactone-therapy
#18
Z Ashley, C Leader, I Sammut, F McDonald, R Walker, M Fronius
OBJECTIVE: Hypertension (HTN) impairs the regulation of blood flow leading to cardiovascular morbidity and mortality. A "new player" in blood-flow regulation is the endothelium Epithelial Sodium Channel (vascular ENaC). We hypothesise that dysfunction in HTN is due to changes in vascular ENaC activity. Aldosterone regulates renal ENaC and has a pivotal role in HTN and recently it has been suggested that aldosterone antagonism (spironolactone therapy) is beneficial beyond that predicted by the reduction in blood pressure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27451867/indole-3-carbinol-induces-tumor-cell-death-function-follows-form
#19
REVIEW
Bryant W Megna, Patrick R Carney, Manabu Nukaya, Pete Geiger, Gregory D Kennedy
BACKGROUND: Even with colonoscopy screening and preventive measures becoming more commonplace, colorectal cancer (CRC) remains the third leading cause of oncologic death in the United States as of 2014. Many chemotherapeutics exist for the treatment of colorectal cancer, though they often come with significant side effect profiles or narrow efficacy ranges in terms of patient profile. Dietary phytochemicals such as glucobrassicin and its metabolite indole-3-carbinol (I3C) have been implicated in tumor prevention in many preclinical models across a variety of gastrointestinal tumors and represent an intriguing new class of natural chemotherapeutics for CRC...
July 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27433903/the-aryl-hydrocarbon-receptor-is-a-repressor-of-inflammation-associated-colorectal-tumorigenesis-in-mouse
#20
Carol J Díaz-Díaz, Sean M Ronnekleiv-Kelly, Manabu Nukaya, Peter G Geiger, Silvia Balbo, Romel Dator, Bryant W Megna, Patrick R Carney, Christopher A Bradfield, Gregory D Kennedy
OBJECTIVE: To determine the role of the aryl hydrocarbon receptor (AHR) in colitis-associated colorectal tumorigenesis. BACKGROUND: Colorectal cancer (CRC) is the third most commonly diagnosed cancer in United States. Chronic intestinal inflammation increases the risk for the development of CRC. We investigated the involvement of AHR, a ligand-activated transcriptional regulator, in colitis-associated colorectal tumorigenesis. METHODS: We used a mouse model of colitis-associated colorectal tumorigenesis that employs treatment with azoxymethane and dextran sodium sulfate...
September 2016: Annals of Surgery
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