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Inflammation and Cardiovascular disease

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https://www.readbyqxmd.com/read/29905812/defective-cholesterol-metabolism-in-haematopoietic-stem-cells-promotes-monocyte-driven-atherosclerosis-in-rheumatoid-arthritis
#1
Dragana Dragoljevic, Michael J Kraakman, Prabhakara R Nagareddy, Devi Ngo, Waled Shihata, Helene L Kammoun, Alexandra Whillas, Man Kit Sam Lee, Annas Al-Sharea, Gerard Pernes, Michelle C Flynn, Graeme I Lancaster, Mark A Febbraio, Jaye Chin-Dusting, Beatriz Y Hanaoka, Ian P Wicks, Andrew J Murphy
Aim: Rheumatoid arthritis (RA) is associated with an approximately two-fold elevated risk of cardiovascular (CV)-related mortality. Patients with RA present with systemic inflammation including raised circulating myeloid cells, but fail to display traditional CV risk-factors, particularly dyslipidaemia. We aimed to explore if increased circulating myeloid cells is associated with impaired atherosclerotic lesion regression or altered progression in RA. Methods and results: Using flow cytometry, we noted prominent monocytosis, neutrophilia, and thrombocytosis in two mouse models of RA...
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29905377/red-blood-cell-adhesion-to-heme-activated-endothelial-cells-reflects-clinical-phenotype-in-sickle-cell-disease
#2
Erdem Kucukal, Anton Ilich, Nigel S Key, Jane A Little, Umut A Gurkan
In sickle cell disease (SCD), 'disease severity' associates with increased RBC adhesion to quiescent endothelium, but the impact on activated endothelium is not known. Increased concentrations of free heme result from intravascular hemolysis in SCD. Heme is essential for aerobic metabolism, and plays an important role in numerous biological processes. Excess free heme induces reactive oxygen species generation and endothelial activation, which are associated with cardiovascular disorders including atherosclerosis, hypertension, and thrombosis...
June 15, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29903731/plasma-ceramides-a-novel-predictor-of-major-adverse-cardiovascular-events-after-coronary-angiography
#3
Jeffrey W Meeusen, Leslie J Donato, Sandra C Bryant, Linnea M Baudhuin, Peter B Berger, Allan S Jaffe
OBJECTIVE: Ceramides are sphingolipids involved with cellular signaling. Synthesis of ceramides occurs in all tissues. Ceramides accumulate within tissues and the blood plasma during metabolic dysfunction, dyslipidemia, and inflammation. Elevations of ceramides are predictive of cardiovascular mortality. We sought to verify the utility of plasma concentrations of 4 ceramides: N-palmitoyl-sphingosine [Cer(16:0)], N-stearoyl-sphingosine [Cer(18:0)], N-nervonoyl-sphingosine [Cer(24:1)], and N-lignoceroyl-sphingosine [Cer(24:0)] in predicting major adverse cardiovascular events in a diverse patient population referred for coronary angiography...
June 14, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29903685/periodontal-disease-systemic-inflammation-and-the-risk-of-cardiovascular-disease
#4
REVIEW
Edgar Francisco Carrizales-Sepúlveda, Alejandro Ordaz-Farías, Raymundo Vera-Pineda, Ramiro Flores-Ramírez
Periodontal and cardiovascular disease are both major health issues. Poor oral health has long been associated with the development of systemic diseases, with the typical example being the risk of endocarditis posterior to dental procedures. Through the years, the association of periodontal disease with other non-infectious systemic diseases has been brought to attention. One of the most interesting associations is the one that exists with the development of cardiovascular disease. Many studies, including systematic reviews and meta-analyses, suggest an important association between periodontal disease and ischaemic heart disease, cerebrovascular disease, heart failure, atrial fibrillation and peripheral artery disease...
June 2, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29899295/impact-of-dietary-cholesterol-on-the-pathophysiology-of-infectious-and-autoimmune-disease
#5
REVIEW
Catherine J Andersen
Cellular cholesterol metabolism, lipid raft formation, and lipoprotein interactions contribute to the regulation of immune-mediated inflammation and response to pathogens. Lipid pathways have been implicated in the pathogenesis of bacterial and viral infections, whereas altered lipid metabolism may contribute to immune dysfunction in autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. Interestingly, dietary cholesterol may exert protective or detrimental effects on risk, progression, and treatment of different infectious and autoimmune diseases, although current findings suggest that these effects are variable across populations and different diseases...
June 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29898822/is-increased-uric-acid-a-risk-factor-or-a-defensive-response-the-campania-salute-network
#6
C Mancusi, R Izzo, L A Ferrara, F Rozza, M A Losi, G Canciello, M Pepe, N de Luca, B Trimarco, G de Simone
BACKGROUND AND AIMS: Circulating uric acid (UA) is positively associated with body mass index (BMI), blood glucose, blood pressure (BP), markers of inflammation, and altered lipid profile. UA has also anti-oxidative properties which might be beneficial for cardiovascular (CV) system. It is still debated whether or not UA is independently associated with increased CV morbidity and/or mortality. METHODS AND RESULTS: We studied prognostic impact of UA in 8833 hypertensive adults (mean age 53 ± 12 yrs, 3857 women) from the Campania Salute Network, without prevalent CV disease and more than stage 3 CKD...
May 4, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29895822/role-of-activating-transcription-factor-3-in-fructose-induced-metabolic-syndrome-in-mice
#7
Chu-Lin Chou, Ching-Hao Li, Heng Lin, Mei-Hui Liao, Chin-Chen Wu, Jin-Shuen Chen, Yuh-Mou Sue, Te-Chao Fang
Activating transcription factor 3 (ATF3) has been implicated in cardiovascular disease and inflammation. This study examined the effects of ATF3 knockout (KO) on blood pressure, glucose intolerance, dyslipidemia, inflammation, and visceral adiposity in mice fed who did and did not consume a high-fructose diet. Male mice were divided into four groups (N = 15 for each group): the Con (control) group (wild-type mice fed a standard chow diet), Fru group (wild-type mice fed a high-fructose [60% fructose] diet), ATF3KO-Con group (ATF3 KO mice fed a standard chow diet), and ATF3KO-Fru group (ATF3 KO mice fed a high-fructose [60% fructose] diet)...
June 12, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29895759/classical-risk-factors-and-inflammatory-biomarkers-one-of-the-missing-biological-links-between-cardiovascular-disease-and-major-depressive-disorder
#8
Thomas C Baghai, Gabriella Varallo-Bedarida, Christoph Born, Sibylle Häfner, Cornelius Schüle, Daniela Eser, Peter Zill, André Manook, Johannes Weigl, Somayeh Jooyandeh, Caroline Nothdurfter, Clemens von Schacky, Brigitta Bondy, Rainer Rupprecht
BACKGROUND: Cardiovascular disorders (CVD) and major depressive disorder (MDD) are the most frequent diseases worldwide responsible for premature death and disability. Behavioral and immunological variables influence the pathophysiology of both disorders. We therefore determined frequency and severity of MDD in CVD and studied whether MDD without CVD or other somatic diseases influences classical and inflammatory biomarkers of cardiovascular risk. In addition, we investigated the influence of proinflammatory cytokines on antidepressant treatment outcome...
June 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29895751/bimodal-function-of-anti-tnf-treatment-shall-we-be-concerned-about-anti-tnf-treatment-in-patients-with-rheumatoid-arthritis-and-heart-failure
#9
REVIEW
Przemyslaw J Kotyla
Treatment with anti-TNF-α (tumor necrosis factor), one of the pivotal cytokines, was introduced to clinical practice at the end of last century and revolutionized the treatment of rheumatoid arthritis (RA) as well as many other inflammatory conditions. Such a treatment may however bring many safety issues regarding infections, tuberculosis, as well as cardiovascular diseases, including heart failure. Given the central role of proinflammatory cytokines in RA, atherosclerosis, and congestive heart failure (CHF), such a treatment might result in better control of the RA process on the one side and improvement of heart function on the other...
June 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29895327/conditioned-medium-from-bone-marrow-derived-mesenchymal-stem-cells-inhibits-vascular-calcification-through-blockade-of-the-bmp2-smad1-5-8-signaling-pathway
#10
Shuangshuang Wang, Siwang Hu, Jian Wang, Yahui Liu, Ruochi Zhao, Maoqing Tong, Hanbin Cui, Nan Wu, Xiaomin Chen
BACKGROUND: Arterial calcification is associated with cardiovascular disease as a complication of advanced atherosclerosis and is a significant contributor to cardiovascular morbidity and mortality. Osteoblastic differentiation of vascular smooth muscle cells (VSMCs) plays an important role in arterial calcification and is characterized by cellular necrosis, inflammation, and lipoprotein and phospholipid complexes, especially in atherosclerotic calcification. The conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) is well known as a rich source of autologous cytokines and is universally used for tissue regeneration in current clinical medicine...
June 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29895294/comparing-the-inflammatory-profiles-for-incidence-of-diabetes-mellitus-and-cardiovascular-diseases-a-prospective-study-exploring-the-common-soil-hypothesis
#11
Xue Bao, Yan Borné, Linda Johnson, Iram Faqir Muhammad, Margaretha Persson, Kaijun Niu, Gunnar Engström
BACKGROUND: Chronic low-grade inflammation and associated insulin resistance and metabolic abnormalities have been proposed as 'common soil' for diabetes mellitus (DM) and cardiovascular disease (CVD). This paper aimed to investigate the inflammatory profiles of DM and CVD and to distinguish their shared and specific markers. METHODS: Based on the Malmö Diet and Cancer cohort, total and differential leukocyte counts were measured in 25,969 participants without previous DM or CVD and were studied in relation to incident DM (mean follow-up 17...
June 12, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29893297/18f-fluorodeoxyglucose-positron-emission-tomography-based-evaluation-of-systemic-and-vascular-inflammation-and-assessment-of-the-effect-of-systemic-treatment-on-inflammation-in-patients-with-moderate-to-severe-psoriasis-a-randomized-placebo-controlled-pilot
#12
Sharonjeet Kaur, Nusrat Shafiq, Sunil Dogra, B R Mittal, Savita Verma Attri, Ajay Bahl, Tarun Narang, Keshavamurthy Vinay, Sujit Rajagopalan, Samir Malhotra
Background: Psoriasis is a systemic inflammatory disorder associated with an increased risk of cardiovascular disease. Objective: To evaluate the utility of [18 F]-fluorodeoxyglucose positron emission tomography/computed tomography in identifying vascular and systemic inflammation in psoriasis patients with moderate-to-severe disease and to analyze its usefulness in assessing the effect of systemic treatment. Methods: This was a randomized, double-blind pilot study conducted in a tertiary care center...
June 8, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29893226/the-pathogenesis-of-psoriatic-arthritis
#13
REVIEW
Douglas J Veale, Ursula Fearon
Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with inflammation of the joints and entheses, including those of the axial skeleton, and is associated with increased mortality from cardiovascular disease. Diagnosis is primarily based on clinical phenotype because of the diversity of the associated features, which can include skin and nail disease, dactylitis, uveitis, and osteitis. Improved understanding of the pathogenesis of psoriatic arthritis has led to the development of effective biologics and small-molecular drugs targeting specific cytokines and signalling pathways, which can prevent disease progression and improve quality of life...
June 2, 2018: Lancet
https://www.readbyqxmd.com/read/29893180/potential-adverse-cardiac-remodelling-in-highly-trained-athletes-still-unknown-clinical-significance
#14
Luigi Gabrielli, Marta Sitges, Mario Chiong, Jorge Jalil, María Ocaranza, Silvana Llevaneras, Sebastian Herrera, Rodrigo Fernandez, Rodrigo Saavedra, Fernando Yañez, Luis Vergara, Alexis Diaz, Sergio Lavandero, Pablo Castro
Moderate endurance exercise has long been considered an essential element to maintain cardiovascular health, and sedentary behaviour in the general population has been related to a significant increase in all-causes of mortality, cardiovascular disease mortality and cardiovascular disease incidence. However, a growing group of people performs an intense exercise that leads to multiple heart adaptive changes that are collectively called "athlete's heart". In this review, we discussed the evidence of cardiac remodelling process secondary to repetitive and strenuous exercise in some predisposed athletes that produces intense and probably deleterious changes in cardiac morphology and function with no clear clinical significance in long-term follow-up...
June 12, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29892284/pcrp-mcrp-dissociation-mechanisms-as-potential-targets-for-the-development-of-small-molecule-anti-inflammatory-chemotherapeutics
#15
REVIEW
Vittorio Caprio, Lina Badimon, Mario Di Napoli, Wen-Hui Fang, Glenn R Ferris, Baoqiang Guo, Rocco S Iemma, Donghui Liu, Yasmin Zeinolabediny, Mark Slevin
Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important disease states including cardiovascular disease and neurodegenerative disorders such as Alzheimer's disease. This pentraxin exerts pro-inflammatory properties via dissociation of the pentamer (pCRP) to a monomeric form (mCRP). This dissociation is induced by binding of pCRP to cell surface phosphocholine residues exposed by the action of phospholipase A2 (PLA2 )...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29891806/anti-atherogenic-effects-of-vaspin-on-human-aortic-smooth-muscle-cell-macrophage-responses-and-hyperlipidemic-mouse-plaque-phenotype
#16
Kengo Sato, Remina Shirai, Maho Yamaguchi, Tomoyuki Yamashita, Koichiro Shibata, Taisuke Okano, Yusaku Mori, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Tsutomu Hirano, Takuya Watanabe
Vaspin (visceral adipose tissue-derived serine protease inhibitor) was recently identified as a novel adipocytokine with insulin-sensitizing effects. Serum vaspin levels are reported either increased or decreased in patients with coronary artery disease. Our translational research was performed to evaluate the expression of vaspin in human coronary atherosclerotic lesions, and its effects on atherogenic responses in human macrophages and human aortic smooth muscle cells (HASMC), as well as aortic atherosclerotic lesion development in spontaneously hyperlipidemic Apoe −/− mice, an animal model of atherosclerosis...
June 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29891569/erectile-dysfunction-as-an-independent-predictor-of-future-cardiovascular-events-the-multi-ethnic-study-of-atherosclerosis
#17
S M Iftekhar Uddin, Mohammadhassan Mirbolouk, Zeina Dardari, David I Feldman, Miguel Cainzos-Achirica, Andrew P DeFilippis, Philip Greenland, Ron Blankstein, Kevin L Billups, Martin Miner, Khurram Nasir, Michael J Blaha
Vascular erectile dysfunction (ED) and cardiovascular disease (CVD) share common risk factors including obesity, hypertension, metabolic syndrome, diabetes mellitus, and smoking. ED and CVD also have common underlying pathological mechanisms, including endothelial dysfunction, inflammation, and atherosclerosis.1 Despite these close relationships, the evidence documenting ED as an independent predictor of future CVD events is limited.We therefore leveraged the MESA study (Multi-Ethnic Study of Atherosclerosis), an ethnically diverse, community-based, multisite prospective cohort study, to examine the value of self-reported ED for predicting incident coronary heart disease (CHD) and CVD in those free of these CVD events at baseline...
June 11, 2018: Circulation
https://www.readbyqxmd.com/read/29890033/bonus-effects-of-anti-diabetic-drugs-possible-beneficial-effects-on-endothelial-dysfunction-vascular-inflammation-and-atherosclerosis
#18
Camila A Pereira, Fernando S Carneiro, Takayuki Matsumoto, Rita C Tostes
Diabetes currently affects more than 400 million people worldwide. This metabolic disorder causes various micro- and macrovascular complications that accelerate atherosclerosis and yet trigger other cardiovascular diseases. The characteristic frame of hyperglycaemia, hyperinsulinaemia and hyperlipidaemia in diabetes increases several inflammatory mediators leading to endothelial dysfunction and pro-atherosclerotic processes. This MiniReview summarizes evidence that anti-diabetic drugs have effects beyond lowering glycaemic levels...
June 11, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29889226/screening-for-nonalcoholic-fatty-liver-disease-in-inflammatory-bowel-diseases-a-cohort-study-using-transient-elastography
#19
Chiara Saroli Palumbo, Sophie Restellini, Che-Yung Chao, Achuthan Aruljothy, Carolyne Lemieux, Gary Wild, Waqqas Afif, Peter L Lakatos, Alain Bitton, Sila Cocciolillo, Peter Ghali, Talat Bessissow, Giada Sebastiani
Background: Inflammatory bowel disease (IBD) patients may be at risk for nonalcoholic fatty liver disease (NAFLD) due to chronic inflammation, hepatotoxic drugs, and alteration of the gut microbiota. Prospective data using accurate diagnostic methods are lacking. Methods: We prospectively investigated prevalence and predictors of NAFLD and liver fibrosis by transient elastography (TE) with associated controlled attenuation parameter (CAP) in IBD patients as part of a routine screening program...
June 7, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29887581/utility-of-arterial-blood-gas-cbc-biochemistry-and-cardiac-hormones-as-evaluation-parameters-of-cardiovascular-disease-in-nonhuman-primates
#20
Shunya Nakayama, Hiroshi Koie, Kiichi Kanayama, Yuko Katakai, Yasuyo Ito-Fujishiro, Tadashi Sankai, Yasuhiro Yasutomi, Naohide Ageyama
Cardiovascular disease (CVD) has a tremendous impact on the quality of life of humans. While experimental animals are valuable to medical research as models of human diseases, cardiac systems differ widely across various animal species. Thus, we examined a CVD model in cynomolgus monkeys. Laboratory primates are precious resources, making it imperative that symptoms of diseases and disorders are detected as early as possible. Thus, in this study we comprehensively examined important indicators of CVD in cynomolgus monkeys, including arterial blood gas, complete blood count (CBC), biochemistry, and cardiac hormones...
June 11, 2018: Journal of Veterinary Medical Science
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